Discovery Talks are the research community's international seminar series. Featuring influential research leaders from around the globe, the series promotes knowledge exchange, fosters international collaborations and showcases the latest innovations in research.
The Childhood Diseases Research Theme at BC Children’s Hospital presents:

Control of Pathogen Colonization
by Host Immunity and the Microbiota in the Gut

Dr. Gabriel Núñez, MD
Paul de Kruif Endowed Professor, Inflammation & Immunology, University of Michigan School of Medicine

Learning Objectives:

  1. Understand how a pathogen colonizes the gut in the presence of the microbiota
  2. Understand how host immunity targets virulent pathogens in the gut
  3. Understand the role of the microbiota in preventing the colonization of enteric pathogens


The seminar is scheduled for Thursday, November 16, 2017, 10:30 - 11:30 a.m. at the Chan Centre for Family Health Education (Map), BC Children's Hospital Research Institute. 

Missed the presentation? You can watch the full recording here.


Discovery Talks is accredited as a self-approved group learning activity (Section 1) as defined by the Maintenance of Certification program of the Royal College of Physicians and Surgeons of Canada. CME credits are available for all participants.

About the Speaker

Dr. Gabriel Núñez earned his MD degree from the University of Seville, Spain, in 1977. He received postdoctoral training in Immunology at the University of Texas Southwestern Medical Center, Dallas (1979–1984) and residency training in Anatomical Pathology at Washington University in St. Louis (1985–1990).

In 1987, he joined the laboratory of Stanley Korsmeyer at Washington University, where he studied the function of the anti-apoptotic protein BCL-2. In 1991, Dr. Núñez joined the Department of Pathology at the University of Michigan in Ann Arbor as an Assistant Professor and was promoted to full Professor in 2001. He holds the Paul de Kruif Endowed Professorship in Academic Pathology.

His laboratory identified NOD1 and NOD2, the first members of the Nod-like receptor (NLR) family, a class of pattern-recognition receptors that mediate cytosolic sensing of microbial organisms. Dr. Núñez and his colleagues showed that genetic variation in a NLR family member, NOD2, is strongly associated with susceptibility to Crohn's disease. Currently, the Núñez laboratory is interested in signaling pathways regulating innate immunity, the pathogenesis of inflammatory disease and the role of the microbiota in host defense and colitis. 

Dr. Núñez is the author of more than 375 scientific publications. His research program is supported by grants from the National Institutes of Health. 

Video recordings of previous lectures are available online: Video Library. These may be useful for classes, or of interest to those who are unable to attend events. 

For more information, contact