Overview

In 1995, as a new graduate student in the department of psychiatry, I began investigating the morphological phenomena of schizophrenia and related psychotic disorders. These initial in-vivo investigations involved the application of CT (Computed Tomography) imaging to examine phenotypic characteristics of brain morphology in families affected by schizophrenia. Since that time, my research has moved forward into multi-modal applications of MRI (magnetic resonance imaging) to investigate the effects of antipsychotic medications on brain structure in schizophrenia, the relationships between structure, symptoms and cognition in psychotic disorders and first-episode psychosis, and more recently, the interactions between substance abuse, psychosis and systemic infections on brain morphology.

Currently, all my neuroimaging research data are obtained at UBC on the high-field research scanner, which produces exceptionally high quality scans and gives researchers the capability to examine physiological, biochemical and physical markers in the brain. This has allowed me, along with the residents and graduate students I work with, to examine the neurocircuitry and metabolic characteristics of psychotic disorders using diffusion tensor imaging and susceptibility-weighted imaging. My current projects involve the investigation of the effects of exercise on hipppocampal volume and vascularization in chronic schizophrenia patients and in adolescent psychosis patients. Additionally, I am involved in a large longitudinal imaging study of multi-diagnosis addiction, psychosis and infection subjects over the course of 5-8 years. Some of the goals of this study include investigating the interactions of life circumstances, addiction, mental illness and physical illnesses in an urban population, and how these interactions have affected quality of life, health care access, persistence of mental disorder/addictions and neurobiological integrity.

Publications

Using serial position effects to investigate memory dysfunction in homeless and precariously housed persons
Clinical Neuropsychologist
Gicas, K.M. and Benitah, K. and Thornton, A.E. and Petersson, A.M. and Jones, P.W. and Stubbs, J.L. and Jones, A.A. and Panenka, W.J. and Lang, D.J. and Leonova, O. and Vila-Rodriguez, F. and Barr, A.M. and Buchanan, T. and Su, W. and Vertinsky, A.T. and Rauscher, A. and MacEwan, G.W. and Honer, W.G.
DOI: 10.1080/13854046.2023.2178513
2023

Pain, opioid use, depressive symptoms, and mortality in adults living in precarious housing or homelessness: a longitudinal prospective study
Pain
Andrea A. Jones and Lianne L. Cho and David D. Kim and Skye P. Barbic and Olga Leonova and Alexandra Byford and Tari Buchanan and Fidel Vila-Rodriguez and Ric M. Procyshyn and Donna J. Lang and A. Talia Vertinsky and G. William MacEwan and Alexander Rauscher and William J. Panenka and Allen E. Thornton and Alasdair M. Barr and Thalia S. Field and William G. Honer
DOI: 10.1097/j.pain.0000000000002619
11/2022

Dynamic networks of psychotic symptoms in adults living in precarious housing or homelessness
Psychological Medicine
Andrea A. Jones and Kristina M. Gicas and Sara Mostafavi and Melissa L. Woodward and Olga Leonova and Fidel Vila-Rodriguez and Ric M. Procyshyn and Alex Cheng and Tari Buchanan and Donna J. Lang and G. William MacEwan and William J. Panenka and Alasdair M. Barr and Allen E. Thornton and William G. Honer
DOI: 10.1017/S0033291720004444
10/2022

Traumatic brain injury in precariously housed persons: Incidence and risks
eClinicalMedicine
O'Connor, T.A. and Panenka, W.J. and Livingston, E.M. and Stubbs, J.L. and Askew, J. and Sahota, C.S. and Feldman, S.J. and Buchanan, T. and Xu, L. and Hu, X.J. and Lang, D.J. and Woodward, M.L. and Thornton, W.L. and Gicas, K.M. and Vertinsky, A.T. and Heran, M.K. and Su, W. and MacEwan, G.W. and Barr, A.M. and Honer, W.G. and Thornton, A.E.
DOI: 10.1016/j.eclinm.2022.101277
2022

Cerebellar and brainstem differences in children with developmental coordination disorder: A voxel-based morphometry study
Frontiers in Human Neuroscience
Gill, K.K. and Lang, D. and Zwicker, J.G.
DOI: 10.3389/fnhum.2022.921505
2022

Cerebellar Differences after Rehabilitation in Children with Developmental Coordination Disorder
Brain Sciences
Gill, K.K. and Lang, D. and Zwicker, J.G.
DOI: 10.3390/brainsci12070856
2022

Risk factors for hippocampal cavities in a marginally housed population
Hippocampus
Cheng, A.Y.T. and Stubbs, J.L. and Barr, A.M. and Gicas, K.M. and Su, W. and Thornton, A.E. and Lang, D.J. and Hamzah, Y. and Leonova, O. and MacEwan, W.G. and Rauscher, A. and Honer, W.G. and Panenka, W.J.
DOI: 10.1002/hipo.23450
2022

Characterizing Traumatic Brain Injury and Its Association with Losing Stable Housing in a Community-based Sample,Caractérisation d’une lésion cérébrale traumatique et de son association avec la perte d’un logement stable dans un échantillon communautaire
Canadian Journal of Psychiatry
Stubbs, J.L. and Thornton, A.E. and Gicas, K.M. and O?Connor, T.A. and Livingston, E.M. and Lu, H.Y. and Mehta, A.K. and Lang, D.J. and Vertinsky, A.T. and Field, T.S. and Heran, M.K. and Leonova, O. and Sahota, C.S. and Buchanan, T. and Barr, A.M. and MacEwan, G.W. and Rauscher, A. and Honer, W.G. and Panenka, W.J.
DOI: 10.1177/07067437211000665
2022

Characterization of Bodily Pain and Use of Both Prescription and Non-Prescription Opioids in Tenants of Precarious Housing
Substance Use and Misuse
Lei, M. and Rintoul, K. and Stubbs, J.L. and Kim, D.D. and Jones, A.A. and Hamzah, Y. and Procyshyn, R.M. and Gicas, K.M. and Cho, L.L. and Panenka, W.J. and Thornton, A.E. and Lang, D.J. and MacEwan, G.W. and Honer, W.G. and Barr, A.M.
DOI: 10.1080/10826084.2021.1958865
2021

Differential age-associated brain atrophy and white matter changes among homeless and precariously housed individuals compared to the general population
medRxiv
Stubbs, J.L. and Jones, A.A. and Wolfman, D. and Chan, R.C.Y. and Vertinsky, A.T. and Heran, M.K. and Su, W. and Lang, D. and Field, T.S. and Gicas, K.M. and Woodward, M.L. and Thornton, A.E. and Barr, A.M. and Leonova, O. and MacEwan, G.W. and Rauscher, A. and Honer, W.G. and Panenka, W.J.
DOI: 10.1101/2021.11.03.21265661
2021

Component Processes of Decision Making in a Community Sample of Precariously Housed Persons: Associations With Learning and Memory, and Health-Risk Behaviors
Frontiers in Psychology
Baitz, H.A. and Jones, P.W. and Campbell, D.A. and Jones, A.A. and Gicas, K.M. and Giesbrecht, C.J. and Loken Thornton, W. and Barone, C.C. and Wang, N.Y. and Panenka, W.J. and Lang, D.J. and Vila-Rodriguez, F. and Leonova, O. and Barr, A.M. and Procyshyn, R.M. and Buchanan, T. and Rauscher, A. and MacEwan, G.W. and Honer, W.G. and Thornton, A.E.
DOI: 10.3389/fpsyg.2021.571423
2021

Differential effects of cannabis exposure during early versus later adolescence on the expression of psychosis in homeless and precariously housed adults
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Gicas, K.M. and Cheng, A. and Panenka, W.J. and Kim, D.D. and Yau, J.C. and Procyshyn, R.M. and Stubbs, J.L. and Jones, A.A. and Bains, S. and Thornton, A.E. and Lang, D.J. and Vertinsky, A.T. and Rauscher, A. and Honer, W.G. and Barr, A.M.
DOI: 10.1016/j.pnpbp.2020.110084
2021

Psychometric properties and correlates of the Beck Depression Inventory in a community-based and homeless or precariously housed sample
Journal of Affective Disorders Reports
Cho, L.L. and Jones, A.A. and Barbic, S. and Leonova, O. and Vila-Rodriguez, F. and Buchanan, T. and Lang, D.J. and William MacEwan, G. and Procyshyn, R.M. and Panenka, W.J. and Barr, A.M. and Thornton, A.E. and Gicas, K.M. and Honer, W.G.
DOI: 10.1016/j.jadr.2021.100229
2021

Cerebral Small Vessel Disease, Risk Factors, and Cognition in Tenants of Precarious Housing.
Stroke
Zhou LW and Panenka WJ and Al-Momen G and Gicas KM and Thornton AE and Jones AA and Woodward M and Heran MKS and Vertinsky AT and Su W and Barr AM and MacEwan GW and Lang DJ and Field TS
DOI: 10.1161/strokeaha.120.030446
PubMed: 33019899
10/2020

Medial temporal lobe cortical changes in response to exercise interventions in people with early psychosis: A randomized controlled trial
Schizophrenia Research
Melissa L. Woodward and Jingxia Lin and Kristina M. Gicas and Wayne Su and Christy L.M. Hui and William G. Honer and Eric Y.H. Chen and Donna J. Lang
DOI: 10.1016/j.schres.2020.05.043
09/2020

Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada.
PLoS medicine
Jones AA and Gicas KM and Seyedin S and Willi TS and Leonova O and Vila-Rodriguez F and Procyshyn RM and Smith GN and Schmitt TA and Vertinsky AT and Buchanan T and Rauscher A and Honer WG
DOI: 10.1371/journal.pmed.1003172
PubMed: 32628679
07/2020

Amygdala Nuclei Volumes Are Selectively Associated With Social Network Size in Homeless and Precariously Housed Persons.
Frontiers in behavioral neuroscience
Jones PW and Thornton AE and Jones AA and Knerich VM and Lang DJ and Woodward ML and Panenka WJ and Su W and Barr AM and Buchanan T and Honer WG and Gicas KM
DOI: 10.3389/fnbeh.2020.00097
PubMed: 32612516
06/2020

Cognitive decline and mortality in a community-based sample of homeless and precariously housed adults: 9-year prospective study.
BJPsych open
Gicas KM and Jones AA and Thornton AE and Petersson A and Livingston E and Waclawik K and Panenka WJ and Barr AM and Lang DJ and Vila-Rodriguez F and Leonova O and Procyshyn RM and Honer WG
DOI: 10.1192/bjo.2020.3
PubMed: 32043436
02/2020

Cerebral small vessel disease, risk factors, and cognition in tenants of precarious housing
Stroke
Zhou, L.W. and Panenka, W.J. and Al-Momen, G. and Gicas, K.M. and Thornton, A.E. and Jones, A.A. and Woodward, M. and Heran, M.K.S. and Vertinsky, A.T. and Su, W. and Barr, A.M. and Macewan, G.W. and Lang, D.J. and Rauscher, A. and Honer, W.G. and Field, T.S.
DOI: 10.1161/STROKEAHA.120.030446
2020

Decreased medial entorhinal cortical thickness in olanzapine exposed female rats is not ameliorated by exercise
Pharmacology Biochemistry and Behavior
Woodward, M.L. and Ker, A.H. and Barr, A.M. and Beasley, C.L. and Hercher, C. and Boyda, H.N. and Procyshyn, R.M. and Honer, W.G. and Lang, D.J.
DOI: 10.1016/j.pbb.2019.172834
2020

Cognitive Impairment in Marginally Housed Youth: Prevalence and Risk Factors.
Frontiers in public health
Waclawik K and Jones AA and Barbic SP and Gicas KM and O'Connor TA and Smith GN and Leonova O and Mathias S and Barr AM and Procyshyn RM and Lang DJ and Woodward ML and MacEwan GW and Thornton AE
DOI: 10.3389/fpubh.2019.00270
PubMed: 31649909
10/2019

Myelin Water Atlas: A Template for Myelin Distribution in the Brain.
Journal of neuroimaging : official journal of the American Society of Neuroimaging
Liu H and Rubino C and Dvorak AV and Jarrett M and Ljungberg E and Vavasour IM and Lee LE and Kolind SH and MacMillan EL and Traboulsee A and Lang DJ and Rauscher A and Li DKB and Laule C
DOI: 10.1111/jon.12657
PubMed: 31347238
07/2019

Prevalence and Risk Factors of Brain Infarcts and Associations With Cognitive Performance in Tenants of Marginal Housing.
Journal of the American Heart Association
Zhou LW and Panenka WJ and Jones AA and Gicas KM and Thornton AE and Heran MKS and Volders D and Lang DJ and Vertinsky AT and Rauscher A and Su W and Barr AM and MacEwan GW and Honer WG and Field TS
DOI: 10.1161/JAHA.118.011412
PubMed: 31242796
06/2019

Volumes of the Hippocampal Formation Differentiate Component Processes of Memory in a Community Sample of Homeless and Marginally Housed Persons.
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
Gicas KM and Thornton AE and Waclawik K and Wang N and Jones AA and Panenka WJ and Lang DJ and Smith GN and Vila-Rodriguez F and Leonova O and Barr AM and Procyshyn RM and Buchanan T and Honer WG
DOI: 10.1093/arclin/acy066
PubMed: 30407496
06/2019

Cognitive profiles and associated structural brain networks in a multimorbid sample of marginalized adults.
PloS one
Gicas KM and Jones AA and Panenka WJ and Giesbrecht C and Lang DJ and Vila-Rodriguez F and Leonova O and Barr AM and Procyshyn RM and Su W and Rauscher A and Vertinsky AT and Honer WG
DOI: 10.1371/journal.pone.0218201
PubMed: 31194834
06/2019

A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.
Psychopharmacology
Alexander PD and Gicas KM and Cheng A and Lang DJ and Procyshyn RM and Vertinsky AT and Panenka WJ and Thornton AE and Rauscher A and Wong JYX and Chan T and Jones AA and Barr AM
DOI: 10.1007/s00213-019-05298-w
PubMed: 31230145
06/2019

Parcellation of the human hippocampus based on gray matter volume covariance: Replicable results on healthy young adults.
Human brain mapping
Ge R and Kot P and Liu X and Lang DJ and Wang JZ and Honer WG and Vila-Rodriguez F
DOI: 10.1002/hbm.24628
PubMed: 31115118
05/2019

Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing.
Brain and behavior
Gicas KM and Cheng A and Rawtaer I and Willi TS and Panenka WJ and Lang DJ and Smith GN and Vila-Rodriguez F and Leonova O and Giesbrecht CJ and Jones AA and Barr AM and Procyshyn RM and Honer WG
DOI: 10.1002/brb3.1233
PubMed: 30724486
02/2019

Characterizing traumatic brain injury and its association with homelessness in a community-based sample of precariously housed adults and youth
medRxiv
Stubbs, J.L. and Thornton, A.E. and Gicas, K.M. and O?Connor, T.A. and Livingston, E.M. and Lu, H.Y. and Mehta, A.K. and Lang, D.J. and Vertinsky, A.T. and Field, T.S. and Heran, M.K. and Leonova, O. and Buchanan, T. and Barr, A.M. and MacEwan, G.W. and Honer, W.G. and Panenka, W.J.
DOI: 10.1101/19004606
2019

Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder
NeuroImage: Clinical
Jaspers-Fayer, F. and Lin, S.Y. and Chan, E. and Ellwyn, R. and Lim, R. and Best, J. and Belschner, L. and Lang, D. and Heran, M.K.M. and Woodward, T.S. and Stewart, S.E.
DOI: 10.1016/j.nicl.2019.102034
2019

Hippocampal volume and vasculature before and after exercise in treatment-resistant schizophrenia.
Schizophrenia research
Woodward ML and Gicas KM and Warburton DE and White RF and Rauscher A and Leonova O and Su W and Smith GN and Thornton AE and Vertinsky AT and Phillips AA and Goghari VM and Honer WG and Lang DJ
DOI: 10.1016/j.schres.2018.06.054
PubMed: 30539767
06/2018

Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study
Canadian Journal of Public Health
Skye P. Barbic and Andrea A. Jones and Melissa Woodward and Matt Piercy and Steve Mathias and Fidel Vila-Rodriguez and Olga Leonova and Geoffrey N. Smith and Tari Buchanan and Alexandra T. Vertinsky and Stephanie Gillingham and William J. Panenka and Alexander Rauscher and Alasdair M. Barr and Ric M. Procyshyn and G. William MacEwan and Donna J. Lang and Allen E. Thornton and Manraj K. Heran and Adelena M. Leon and Michael Krausz and William G. Honer
DOI: 10.17269/s41997-018-0087-9
05/2018

Musical deficits and cortical thickness in people with schizophrenia.
Schizophrenia research
Fujito R and Minese M and Hatada S and Kamimura N and Morinobu S and Lang DJ and Honer WG and Sawada K
DOI: 10.1016/j.schres.2018.01.027
PubMed: 29454511
02/2018

Reduced cardiovascular fitness associated with exposure to clozapine in individuals with chronic schizophrenia
Psychiatry Research
David D. Kim and Donna J. Lang and Ric M. Procyshyn and Melissa L. Woodward and Kai Kaufman and Randall F. White and William G. Honer and Darren E.R. Warburton
DOI: 10.1016/j.psychres.2018.01.029
01/2018

Structural brain changes in first episode mania with and without psychosis: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
World Journal of Biological Psychiatry
Keramatian, K. and Dhanoa, T. and McGirr, A. and Lang, D.J. and Honer, W.G. and Lam, R.W. and Yatham, L.N.
DOI: 10.1080/15622975.2016.1249950
2018

Subcortical structural volumes in recently remitted first episode mania
Journal of Affective Disorders
Shyam Sundar Arumugham and Ivan J. Torres and Donna J. Lang and Wayne Su and Raymond W. Lam and William G. Honer and Lakshmi N. Yatham
DOI: 10.1016/j.jad.2017.06.051
11/2017

Exercise-associated extrapyramidal symptoms during treatment with long-acting injectable antipsychotic medications: A case report
Clinical Schizophrenia & Related Psychoses
David D. Kim and Donna J. Lang and Darren E. R. Warburton and Alasdair M. Barr and Randall F. White and William G. Honer and Ric M. Procyshyn
DOI: 10.3371/csrp.dkdl.071317
08/2017

Heart-rate response to alpha2-adrenergic receptor antagonism by antipsychotics
Clinical Autonomic Research
David D. Kim and Donna J. Lang and Darren E. R. Warburton and Melissa L. Woodward and Randall F. White and Alasdair M. Barr and William G. Honer and Ric M. Procyshyn
DOI: 10.1007/s10286-017-0444-4
07/2017

Effects of Exercise on Serum Triglycerides and Symptoms of Schizophrenia
Journal of Clinical Psychopharmacology
David D. Kim and Donna J. Lang and Darren E.R. Warburton and Alasdair M. Barr and Geoffrey N. Smith and Allen E. Thornton and Randall F. White and William G. Honer and Ric M. Procyshyn
DOI: 10.1097/jcp.0000000000000648
04/2017

Diagnosis and body mass index effects on hippocampal volumes and neurochemistry in bipolar disorder
Translational Psychiatry
D J Bond and L E Silveira and E L MacMillan and I J Torres and D J Lang and W Su and W G Honer and R W Lam and L N Yatham
DOI: 10.1038/tp.2017.42
03/2017

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence
Psychopharmacology
Peter D Alexander and Kristina M Gicas and Taylor S Willi and Clara N Kim and Veronika Boyeva and Ric M Procyshyn and Geoff N. Smith and Allen E Thornton and William J Panenka and Andrea A. Jones and Fidel Vila-Rodriguez and Donna J. Lang and G William MacEwan and William G Honer and Alasdair M Barr
DOI: 10.1007/s00213-017-4551-7
02/2017

The Hotel Study—Clinical and Health Service Effectiveness in a Cohort of Homeless or Marginally Housed Persons
The Canadian Journal of Psychiatry
William G. Honer and Alejandro Cervantes-Larios and Andrea A. Jones and Fidel Vila-Rodriguez and Julio S. Montaner and Howard Tran and Jimmy Nham and William J. Panenka and Donna J. Lang and Allen E. Thornton and Talia Vertinsky and Alasdair M. Barr and Ric M. Procyshyn and Geoffrey N. Smith and Tari Buchanan and Mel Krajden and Michael Krausz and G. William MacEwan and Kristina M. Gicas and Olga Leonova and Verena Langheimer and Alexander Rauscher and Krista Schultz
DOI: 10.1177/0706743717693781
02/2017

Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness.
Neuropsychology
Kristina M. Gicas and Chantelle J. Giesbrecht and William J. Panenka and Donna J. Lang and Geoffrey N. Smith and Fidel Vila-Rodriguez and Olga Leonova and Andrea A. Jones and Alasdair M. Barr and Ric M. Procyshyn and Tari Buchanan and G. William MacEwan and Wayne Su and A. Talia Vertinsky and Alexander Rauscher and William G. Honer and Allen E. Thornton
DOI: 10.1037/neu0000304
01/2017

Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
Neuropsychiatric Disease and Treatment
Fidel Vila-Rodriguez and Donna Lang and Heather Baitz and Kristina Gicas and Allen Thornton and Thomas Ehmann and Geoff N. Smith and Alasdair Barr and Ivan J. Torres and Lili Kopala and G. William MacEwan and Daniel Müller and James Kennedy and William Honer
DOI: 10.2147/ndt.s150488
2017

Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users
Addiction Biology
Willi, T.S. and Barr, A.M. and Gicas, K. and Lang, D.J. and Vila-Rodriguez, F. and Su, W. and Thornton, A.E. and Leonova, O. and Giesbrecht, C.J. and Procyshyn, R.M. and Rauscher, A. and MacEwan, W.G. and Honer, W.G. and Panenka, W.J.
DOI: 10.1111/adb.12363
2017

Traumatic Brain Injury in a Community-Based Cohort of Homeless and Vulnerably Housed Individuals
Journal of Neurotrauma
Schmitt, T. and Thornton, A.E. and Rawtaer, I. and Barr, A.M. and Gicas, K.M. and Lang, D.J. and Vertinsky, A.T. and Rauscher, A. and Procyshyn, R.M. and Buchanan, T. and Cheng, A. and Mackay, S. and Leonova, O. and Langheimer, V. and Field, T.S. and Heran, M.K. and Vila-Rodriguez, F. and O'Connor, T.A. and Macewan, G.W. and Honer, W.G. and Panenka, W.J.
DOI: 10.1089/neu.2017.5076
2017

Effects of exercise on serum triglycerides and symptoms of schizophrenia
Journal of Clinical Psychopharmacology
Kim, D.D. and Lang, D.J. and Warburton, D.E.R. and Barr, A.M. and Smith, G.N. and Thornton, A.E. and White, R.F. and Honer, W.G. and Procyshyn, R.M.
DOI: 10.1097/JCP.0000000000000648
2017

Verbal memory improvement in first-episode psychosis APOE-e4 carriers: A pleiotropic effect?
Neuropsychiatric Disease and Treatment
Vila-Rodriguez, F. and Lang, D.J. and Baitz, H. and Gicas, K. and Thorton, A.E. and Ehmann, T.S. and Smith, G.N. and Barr, A.M. and Torres, I.J. and Kopala, L.C. and William Macewan, G. and Müller, D.J. and Kennedy, J.L. and Honer, W.G.
DOI: 10.2147/NDT.S150488
2017

Microbleeds in Alzheimer’s Disease: A Neuropsychological Overview and Meta-Analysis
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Amir A. Sepehry and Alexander Rauscher and Ging-Yuek Hsiung and Donna J. Lang
DOI: 10.1017/cjn.2016.296
11/2016

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users
Schizophrenia Research
Taylor S. Willi and Donna J. Lang and William G. Honer and Geoff N. Smith and Allen E. Thornton and William J. Panenka and Ric M. Procyshyn and Fidel Vila-Rodriguez and Wayne Su and A. Talia Vertinsky and Olga Leonova and Alexander Rauscher and G. William MacEwan and Alasdair M. Barr
DOI: 10.1016/j.schres.2016.08.001
10/2016

RE: Elucidating Pretreatment Cognitive Impairment in Breast Cancer Patients: The Impact of Cancer-Related Post-traumatic Stress
Journal of the National Cancer Institute
Amir Ali Sepehry and Scott Tyldesley and Margot Kathleen Davis and Christine Simmons and Alexander Rauscher and Donna Jane-Mai Lang
DOI: 10.1093/jnci/djw048
04/2016

Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder
British Journal of Psychiatry
David J. Bond and Leonardo Evangelista da Silveira and Erin L. MacMillan and Ivan J. Torres and Donna J. Lang and Wayne Su and William G. Honer and Raymond W. Lam and Lakshmi N. Yatham
DOI: 10.1192/bjp.bp.115.163360
02/2016

Prevalence of Brain Microbleeds in Alzheimer Disease: A Systematic Review and Meta-Analysis on the Influence of Neuroimaging Techniques
American Journal of Neuroradiology
A.A. Sepehry and D. Lang and G.-Y. Hsiung and A. Rauscher
DOI: 10.3174/ajnr.A4525
02/2016

White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection
BMC Research Notes
Victor M. Tang and Donna J. Lang and Chantelle J. Giesbrecht and William J. Panenka and Taylor Willi and Ric M. Procyshyn and Fidel Vila-Rodriguez and Willough Jenkins and Tania Lecomte and Heidi N. Boyda and Ana Aleksic and G. William MacEwan and William G. Honer and Alasdair M. Barr
DOI: 10.1186/s13104-015-1501-5
09/2015

Mortality from treatable illnesses in marginally housed adults: a prospective cohort study
BMJ Open
Andrea A Jones and Fidel Vila-Rodriguez and Olga Leonova and Verena Langheimer and Donna J Lang and Alasdair M Barr and Ric M Procyshyn and Geoffrey N Smith and Krista Schultz and Tari Buchanan and Michael Krausz and Julio S Montaner and G William MacEwan and Alexander Rauscher and William J Panenka and Allen E Thornton and William G Honer
DOI: 10.1136/bmjopen-2015-008876
08/2015

Hippocampal Subfield Volumes in First Episode and Chronic Schizophrenia
PLOS ONE
Mitsuhiko Kawano and Ken Sawada and Shinji Shimodera and Yasuhiro Ogawa and Shinji Kariya and Donna J. Lang and Shimpei Inoue and William G. Honer
DOI: 10.1371/journal.pone.0117785
02/2015

Prevalence of Brain Microbleeds in Alzheimer Disease: A Systematic Review and Meta-Analysis on the Influence of Neuroimaging Techniques
American Journal of Neuroradiology
A. A. Sepehry and D. Lang and G.- Y. Hsiung and A. Rauscher
DOI: 10.3174/ajnr.a4525
2015

Cortical morphology and early adverse birth events in men with first-episode psychosis
Psychological Medicine
Smith, G.N. and Thornton, A.E. and Lang, D.J. and Macewan, G.W. and Kopala, L.C. and Su, W. and Honer, W.G.
DOI: 10.1017/S003329171400292X
2015

Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness
Journal of Clinical and Experimental Neuropsychology
Kristina M. Gicas and Fidel Vila-Rodriguez and Karine Paquet and Alasdair M. Barr and Ric M. Procyshyn and Donna J. Lang and Geoffrey N. Smith and Heather A. Baitz and Chantelle J. Giesbrecht and Julio S. Montaner and Mel Krajden and Michael Krausz and G. William MacEwan and William J. Panenka and William G. Honer and Allen E. Thornton
DOI: 10.1080/13803395.2014.963519
11/2014

Body Mass Index–Related Regional Gray and White Matter Volume Reductions in First-Episode Mania Patients
Biological Psychiatry
David J. Bond and Tae Hyon Ha and Donna J. Lang and Wayne Su and Ivan J. Torres and William G. Honer and Raymond W. Lam and Lakshmi N. Yatham
DOI: 10.1016/j.biopsych.2013.08.030
07/2014

Assessment of arterial stiffness among schizophrenia-spectrum disorders using aortic pulse wave velocity and arterial compliance: A pilot study
Psychiatry Research
Aaron A. Phillips and Darren E.R. Warburton and Sean W. Flynn and Diane Fredrikson and Donna J. Lang
DOI: 10.1016/j.psychres.2013.10.020
01/2014

48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
NeuroImage: Clinical
Donna J.M. Lang and Eugene Yip and Alexander L. MacKay and Allen E. Thornton and Fidel Vila-Rodriguez and G. William MacEwan and Lili C. Kopala and Geoffrey N. Smith and Cornelia Laule and Cassie B. MacRae and William G. Honer
DOI: 10.1016/j.nicl.2014.10.006
2014

Cortical morphology and early adverse birth events in men with first-episode psychosis
Psychological Medicine
G. N. Smith and A. E. Thornton and D. J. Lang and G. W. MacEwan and L. C. Kopala and W. Su and W. G. Honer
DOI: 10.1017/s003329171400292x
2014

Personalized Risk Assessment of Drug-Related Harm Is Associated with Health Outcomes
PLoS ONE
Andrea A. Jones and Fidel Vila-Rodriguez and William J. Panenka and Olga Leonova and Verena Strehlau and Donna J. Lang and Allen E. Thornton and Hubert Wong and Alasdair M. Barr and Ric M. Procyshyn and Geoffrey N. Smith and Tari Buchanan and Mel Krajden and Michael Krausz and Julio S. Montaner and G. William MacEwan and David J. Nutt and William G. Honer
DOI: 10.1371/journal.pone.0079754
11/2013

Effects of eight weeks of atypical antipsychotic treatment on middle frontal thickness in drug-naïve first-episode psychosis patients
Schizophrenia Research
Vina M. Goghari and Geoffrey N. Smith and William G. Honer and Lili C. Kopala and Allen E. Thornton and Wayne Su and G. William MacEwan and Donna J. Lang
DOI: 10.1016/j.schres.2013.06.025
09/2013

Management of Medication-Related Cardiometabolic Risk in Patients with Severe Mental Illness
Current Cardiovascular Risk Reports
Donna J. Lang and Alasdair M. Barr and Ric M. Procyshyn
DOI: 10.1007/s12170-013-0321-1
06/2013

Relationships Among Depression, PTSD, Methamphetamine Abuse, and Psychosis
Journal of Dual Diagnosis
Tania Lecomte and Karine Paquin and Kim T. Mueser and G. William MacEwan and Elliot Goldner and Allen E. Thornton and Johann Brink and Donna Lang and Shimi Kang and Alasdair M. Barr and William G. Honer
DOI: 10.1080/15504263.2013.778930
05/2013

The Health Benefits and Challenges of Exercise Training in Persons Living with Schizophrenia: A Pilot Study
Brain Sciences
Shannon Bredin and Darren Warburton and Donna Lang
DOI: 10.3390/brainsci3020821
05/2013

Predictors of Persistent Psychotic Symptoms in Persons With Methamphetamine Abuse Receiving Psychiatric Treatment
The Journal of Nervous and Mental Disease
Tania Lecomte and Kim T. Mueser and William MacEwan and Allen E. Thornton and Tari Buchanan and Vanessa Bouchard and Elliot Goldner and Johann Brink and Donna Lang and Shimi Kang and Alasdair M. Barr and William G. Honer
DOI: 10.1097/nmd.0000000000000059
2013

The hotel study: Multimorbidity in a community sample living in marginal housing
American Journal of Psychiatry
Vila-Rodriguez, F. and Panenka, W.J. and Lang, D.J. and Thornton, A.E. and Vertinsky, T. and Wong, H. and Barr, A.M. and Procyshyn, R.M. and Sidhu, J.J. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Montaner, J.S. and MacEwan, G.W. and Honer, W.G.
DOI: 10.1176/appi.ajp.2013.12111439
2013

Predictors of persistent psychotic symptoms in persons with methamphetamine abuse receiving psychiatric treatment
Journal of Nervous and Mental Disease
Lecomte, T. and Mueser, K.T. and Macewan, W. and Thornton, A.E. and Buchanan, T. and Bouchard, V. and Goldner, E. and Brink, J. and Lang, D. and Kang, S. and Barr, A.M. and Honer, W.G.
DOI: 10.1097/NMD.0000000000000059
2013

White matter tract abnormalities in first-episode psychosis
Schizophrenia Research
D.Y. Lee and G.N. Smith and W. Su and W.G. Honer and G.W. MacEwan and J.S. Lapointe and A.T. Vertinsky and F. Vila-Rodriguez and L.C. Kopala and D.J. Lang
DOI: 10.1016/j.schres.2012.06.042
10/2012

Comparison of MERGE and Axial T2-Weighted Fast Spin-Echo Sequences for Detection of Multiple Sclerosis Lesions in the Cervical Spinal Cord
American Journal of Roentgenology
Nancy Martin and David Malfair and Yinshan Zhao and David Li and Anthony Traboulsee and Donna Lang and Alexandra Talia Vertinsky
DOI: 10.2214/ajr.11.7039
07/2012

Antipsychotic Medications: Linking Receptor Antagonism to Neuropsychological Functioning in First Episode Psychosis
Journal of the International Neuropsychological Society
Heather A. Baitz and Allen E. Thornton and Ric M. Procyshyn and Geoffrey N. Smith and G. William MacEwan and Lili C. Kopala and Alasdair M. Barr and Donna J. Lang and William G. Honer
DOI: 10.1017/s1355617712000343
04/2012

Hippocampal volume and the brain-derived neurotrophic factor Val66Met polymorphism in first episode psychosis
Schizophrenia Research
Geoffrey N. Smith and Allen E. Thornton and Donna J. Lang and G. William MacEwan and Thomas S. Ehmann and Lili C. Kopala and Karen Tee and Gillian Shiau and Aristotle N. Voineskos and James L. Kennedy and William G. Honer
DOI: 10.1016/j.schres.2011.11.022
02/2012

Comparison of MERGE and axial T2-weighted fast spin-echo sequences for detection of multiple sclerosis lesions in the cervical spinal cord
American Journal of Roentgenology
Martin, N. and Malfair, D. and Zhao, Y. and Li, D. and Traboulsee, A. and Lang, D. and Vertinsky, A.T.
DOI: 10.2214/AJR.11.7039
2012

Antipsychotic medications: Linking receptor antagonism to neuropsychological functioning in first episode psychosis
Journal of the International Neuropsychological Society
Baitz, H.A. and Thornton, A.E. and Procyshyn, R.M. and Smith, G.N. and MacEwan, G.W. and Kopala, L.C. and Barr, A.M. and Lang, D.J. and Honer, W.G.
DOI: 10.1017/S1355617712000343
2012

Short-term stability of T 1 and T 2 relaxation measures in multiple sclerosis normal appearing white matter
Journal of Neurology
Liang, A.L.W. and Vavasour, I.M. and Mädler, B. and Traboulsee, A.L. and Lang, D.J. and Li, D.K.B. and MacKay, A.L. and Laule, C.
DOI: 10.1007/s00415-011-6318-0
2012

First episode psychosis with extrapyramidal signs prior to antipsychotic drug treatment
Chinese Science Bulletin
William G. Honer and Donna J. Lang and Lili C. Kopala and G. William Macewan and Geoffrey N. Smith and Eric Y. H. Chen and Raymond C. K. Chan
DOI: 10.1007/s11434-011-4738-y
09/2011

The Association of Elevated Body Mass Index with Reduced Brain Volumes in First-Episode Mania
Biological Psychiatry
David J. Bond and Donna J. Lang and Melissa M. Noronha and Mauricio Kunz and Ivan J. Torres and Wayne Su and William G. Honer and Raymond W. Lam and Lakshmi N. Yatham
DOI: 10.1016/j.biopsych.2011.02.025
08/2011

Anterior internal capsule volumes increase in patients with schizophrenia switched from typical antipsychotics to olanzapine
Journal of Psychopharmacology
Goghari, V.M. and Lang, D.J. and Khorram, B. and Götz, J. and Vandorpe, R.A. and Smith, G.N. and Kopala, L.C. and Barr, A.M. and Honer, W.G.
DOI: 10.1177/0269881110363314
2011

Profiles of individuals seeking psychiatric help for psychotic symptoms linked to methamphetamine abuse – baseline results from the MAPS (methamphetamine and psychosis study)
Mental Health and Substance Use
Tania Lecomte and Kim T. Mueser and William G. MacEwan and Marie-Christine Laferrière-Simard and Allen E. Thornton and Tari Buchanan and Elliot Goldner and Johann Brink and Tom S. Ehmann and Donna Lang and Shimi Kang and Alasdair M. Barr and William G. Honer
DOI: 10.1080/17523281.2010.504645
09/2010

Prenatal tobacco exposure in first-episode psychosis
Schizophrenia Research
Geoffrey N. Smith and G. William MacEwan and Lili C. Kopala and Thomas S. Ehmann and Kim Good and Allen E. Thornton and Heather Neilson and Donna J. Lang and Alasdair M. Barr and William G. Honer
DOI: 10.1016/j.schres.2010.01.004
06/2010

Localization of the Subthalamic Nucleus: Optimization with Susceptibility-Weighted Phase MR Imaging
American Journal of Neuroradiology
A.T. Vertinsky and V.A. Coenen and D.J. Lang and S. Kolind and C.R. Honey and D. Li and A. Rauscher
DOI: 10.3174/ajnr.a1669
06/2009

Predictors of starting to smoke cigarettes in patients with first episode psychosis
Schizophrenia Research
Geoffrey N. Smith and Hubert Wong and G. William MacEwan and Lili C. Kopala and Thomas S. Ehmann and Allen E. Thornton and Donna J. Lang and Alasdair M. Barr and Ric Procyshyn and Jehanine C. Austin and Sean W. Flynn and William G. Honer
DOI: 10.1016/j.schres.2008.12.013
03/2009

Localization of the subthalamic nucleus: Optimization with susceptibility-weighted phase MR imaging
American Journal of Neuroradiology
Vertinsky, A.T. and Coenen, V.A. and Lang, D.J. and Kolind, S. and Honey, C.R. and Li, D. and Rauscher, A.
DOI: 10.3174/ajnr.A1669
2009

A family-based association study of the myelin-associated glycoprotein and 2???,3???-cyclic nucleotide 3???-phosphodiesterase genes with schizophrenia
Psychiatric Genetics
Aristotle N. Voineskos and Vincenzo de Luca and Natalie L. Bulgin and Quinton van Adrichem and Sajid Shaikh and Donna J. Lang and William G. Honer and James L. Kennedy
DOI: 10.1097/ypg.0b013e3282fa1874
06/2008

MAG Gene Variation and Cortical Gray Matter Volume in First Episode Schizophrenia
Brain Imaging and Behavior
Aristotle N. Voineskos and Donna J. Lang and Gwyneth Zai and Natalie Bulgin and Sajid Shaikh and Wayne Su and Lili C. Kopala and G. William MacEwan and Allen E. Thornton and Geoffrey N. Smith and Jehannine C. Austin and William G. Honer and James L. Kennedy
DOI: 10.1007/s11682-008-9023-6
03/2008

A family-based association study of the myelin-associated glycoprotein and 2',3'-cyclic nucleotide 3'-phosphodiesterase genes with schizophrenia
Psychiatric Genetics
Voineskos, A.N. and De Luca, V. and Bulgin, N.L. and Van Adrichem, Q. and Shaikh, S. and Lang, D.J. and Honer, W.G. and Kennedy, J.L.
DOI: 10.1097/YPG.0b013e3282fa1874
2008

A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia
Schizophrenia Research
William J. Panenka and Babak Khorram and Alasdair M. Barr and Geoffrey N. Smith and Donna J. Lang and Lili C. Kopala and Robert A. Vandorpe and William G. Honer
DOI: 10.1016/j.schres.2007.05.002
08/2007

Reduced Thalamic Volume in Patients With Chronic Schizophrenia After Switching From Typical Antipsychotic Medications to Olanzapine
American Journal of Psychiatry
Babak Khorram and Donna J. Lang and Lili C. Kopala and Robert A. Vandorpe and Qing Rui and Vina M. Goghari and Geoffrey N. Smith and William G. Honer
DOI: 10.1176/ajp.2006.163.11.2005
11/2006

Reduced anterior internal capsule and thalamic volumes in first-episode psychosis
Schizophrenia Research
D.J. Lang and B. Khorram and V.M. Goghari and L.C. Kopala and R.A. Vandorpe and Q. Rui and G.N. Smith and W.G. Honer
DOI: 10.1016/j.schres.2006.05.002
10/2006

The need for speed: An update on methamphetamine addiction.
Journal of Psychiatry & Neuroscience
09/2006

Lateral asymmetry in the shape of brain ventricles in control and schizophrenia groups
2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Graham, J. and Babalola, K.O. and Honer, W.G. and Lang, D. and Kopala, L. and Vandorpe, R.
2006

The need for speed: An update on methamphetamine addiction
Journal of Psychiatry and Neuroscience
Barr, A.M. and Panenka, W.J. and MacEwan, G.W. and Thornton, A.E. and Lang, D.J. and Honer, W.G. and Lecomte, T.
2006

The Genetic and Environmental Basis of the Relationship Between Schizotypy and Personality
The Journal of Nervous and Mental Disease
Kerry L. Jang and Todd S. Woodward and Donna Lang and William G. Honer and W John Livesley
DOI: 10.1097/01.nmd.0000154842.26600.bd
03/2005

Smaller corpus callosum subregions containing motor fibers in schizophrenia
Schizophrenia Research
Vina M. Goghari and Donna J. Lang and Sean W. Flynn and Alex L. MacKay and William G. Honer
DOI: 10.1016/j.schres.2004.08.023
02/2005

Reduced Basal Ganglia Volumes After Switching to Olanzapine in Chronically Treated Patients With Schizophrenia
American Journal of Psychiatry
Donna J. Lang and Lili C. Kopala and Robert A. Vandorpe and Qing Rui and Geoffrey N. Smith and Vina M. Goghari and Jocelyne S. Lapointe and William G. Honer
DOI: 10.1176/ajp.161.10.1829
10/2004

Abnormalities of myelination in schizophrenia detected in vivo with MRI and post-mortem with analysis of oligodendrocyte proteins
Molecular Psychiatry
S W Flynn and D J Lang and A L Mackay and V Goghari and I M Vavasour and K P Whittall and G N Smith and V Arango and J J Mann and A J Dwork and P Falkai and W G Honer
DOI: 10.1038/sj.mp.4001337
08/2003

Developmental abnormalities of the hippocampus in First-Episode schizophrenia
Biological Psychiatry
Geoffrey N Smith and Donna J Lang and Lili C Kopala and Jocelyne S Lapointe and Peter Falkai and William G Honer
DOI: 10.1016/s0006-3223(02)01977-7
04/2003

An Investigation of Morphometric Changes in the Lateral Ventricles of Schizophrenic Subjects
Medical Image Computing and Computer-Assisted Intervention - MICCAI 2003
Kolawole Babalola and Jim Graham and William Honer and Lili Kopala and Donna Lang and Robert Vandorpe
DOI: 10.1007/978-3-540-39903-2_64
2003

Developmental abnormalities of the hippocampus in first-episode schizophrenia
Biological Psychiatry
Smith, G.N. and Lang, D.J. and Kopala, L.C. and Lapointe, J.S. and Falkai, P. and Honer, W.G.
DOI: 10.1016/S0006-3223(02)01977-7
2003

An MRI Study of Basal Ganglia Volumes in First-Episode Schizophrenia Patients Treated With Risperidone
American Journal of Psychiatry
Donna J. Lang and Lili C. Kopala and Robert A. Vandorpe and Qing Rui and Geoffrey N. Smith and Vina M. Goghari and William G. Honer
DOI: 10.1176/appi.ajp.158.4.625
04/2001

No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families
American Journal of Medical Genetics - Neuropsychiatric Genetics
Neves-Pereira, M. and Bassett, A.S. and Honer, W.G. and Lang, D. and King, N.A. and Kennedy, J.L.
DOI: 10.1002/(SICI)1096-8628(19980907)81:53.0.CO;2-W
1998

Sylvian fissure and middle cranial fossae asymmetries in families with schizophrenia
Schizophrenia Research
Donna J. Lang and Anne S. Bassett and Peter Falkai and Geoffrey N. Smith and Jocelyne S. Lapointe and William G. Honer
DOI: 10.1016/s0920-9964(97)82429-2
01/1997

The temporal lobes, reversed asymmetry and the genetics of schizophrenia
NeuroReport
William G. Honer and Anne S. Bassett and Elizabeth Squires-Wheeler and Peter Falkai and Geoffrey N. Smith and Jocelyne S. Lapointe and Charito Canero and Donna J. Lang
DOI: 10.1097/00001756-199512290-00053
1995

Research
Research Group Members

Ava Grier, Masters Student