Publications

A full list of Kobor Lab papers is available here.

Kobor lab authors are in bold

*Equal contribution as first authors

#Equal contribution as senior authors

Human and Social Epigenetics

Distinctions between sex and time in patterns of DNA methylation across puberty. Moore SR, Humphreys KL, Colich NL, Davis EG, Lin DTS, MacIsaac JL, Kobor MS, Gotlib I.H. BMC Genomics. 2020 21(1):389

Genetic susceptibility to asthma increases the vulnerability to indoor air pollution. Hüls A, Vanker A, Gray D, Koen N, MacIsaac JL, Lin DTS, Ramadori KE, Sly PD, Stein DJ, Kobor MS, Zar HJ. Eur Respir J. 2020 55(3):1901831

Biological embedding of experience: A primer on epigenetics Aristizabal MJ, Anreiter I, Halldorsdottir T, Odgers CL, McDade TW, Goldenberg A, Mostafavi S, Kobor MS, Binder EB, Sokolowski MB, O’Donnell KJ.  Proc Nat. Acad Sci USA. 2019 pii:201820838

The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells. McEwen LM, O’Donnell KJ, McGill MG, Edgar RD, Jones MJ, MacIsaac JL, Lin DTS, Ramadori K, Morin A, Gladish N, Garg E, Unternaehrer E, Pokhvisneva I, Karnani N, Kee MZL, Klengel T, Adler NE, Barr RG, Letourneau N, Giesbrecht GF, Reynolds JN, Czamara D, Armstrong JM, Essex MJ, de Weerth C, Beijers R, Tollenaar MS, Bradley B, Jovanovic T, Ressler KJ, Steiner M, Entringer S, Wadhwa PD, Buss C, Bush NR, Binder EB, Boyce WT, Meaney MJ, #Horvath S, #Kobor MS. Proc Natl Acad Sci U S A. 2019 https://www.pnas.org/cgi/doi/10.1073/pnas.1820843116
Associated Resources: Technical Walkthrough, Non-Technical Summary

Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock and risk of early-life allergic sensitization. *Sbihi H, *Jones MJ, MacIsaac JL, Brauer M, Allen RW, Sears MR, Subbarao P, Mandhane PJ, Moraes TJ, Azad MB, Becker AB, Brook JR, #Kobor MS, #Turvey SE. J Allergy Clin Immunol. 2019 pii: S0091-6749(19)31101-7
Associated Resource: Non-Technical Summary

Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood. McDade TW, Ryan CP, Jones MJ, Hoke MK, Borja J, Miller GE, Kuzawa CW, Kobor MS. Am J Phys Anthropol. 2019 169(1):3-11 

Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues. Lussier AA, Bodnar TS, Mingay M, Morin AM, Hirst M, #Kobor MS, #Weinberg J. Front Genet. 2018 9:610 

The biological embedding of early-life socioeconomic status and family adversity in children’s genome-wide DNA methylation. Bush NR, Edgar RD, Park M, MacIsaac JL, McEwen LM, Adler NE, Essex MJ, #Kobor MS, #Boyce WT. Epigenomics. 2018 10(11):1445-1461 
Associated Resources: Technical Walkthrough, Non-Technical Summary

Exposure to childhood abuse is associated with human sperm DNA methylation. Roberts AL, Gladish N, Gatev E, Jones MJ, Chen Y, MacIsaac JL, Tworoger SS, Austin SB, Tanrikut C, Chavarro JE, Baccarelli AA, Kobor MS. Transl Psychiatry. 2018 8(1):194
Selected Press Coverage: CBC, National Post, The Independent (UK)

Children’s biobehavioral reactivity to challenge predicts DNA methylation in adolescence and emerging adulthood. Goodman SJ, Roubinov DS, Bush NR, Park M, Farré P, Emberly E, Hertzman C, Essex MJ, #Kobor MS, #Boyce WT. Dev Sci. 2019 22(2):e12739

DNA methylation as a predictor of fetal alcohol spectrum disorder. Lussier AA, Morin AM, MacIsaac JL, Salmon J, Weinberg J, Reynolds JN, Pavlidis P, Chudley AE, Kobor MS. Clin Epigenetics. 2018 10:5.

DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. O’Donnell KJ, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. Transl Psychiatry. 2018 8(1):15

Epigenetic correlates of neonatal contact in humans. Moore SR, McEwen LM, Quirt J, Morin A, Mah SM, Barr RG, Boyce WT, Kobor MS. Dev Psychopathol. 2017 29(5):1517-1538
Selected Press Coverage: Vancouver Sun, IFLScience

Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region. McEwen LM, Morin AM, Edgar RD, MacIsaac JL, Jones MJ, Dow WH, Rosero-Bixby L, Kobor MS, Rehkopf DH. Epigenetics Chromatin. 2017 10:21

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation. Clifford RL, Jones MJ, MacIsaac JL, McEwen LM, Goodman SJ, Mostafavi S, #Kobor MS, #Carlsten C. J Allergy Clin Immunol. 2017 139(1):112-121

Differential DNA methylation in peripheral blood mononuclear cells in adolescents exposed to significant early but not later childhood adversity. *Esposito EA, *Jones MJ, Doom JR, MacIsaac JL, Gunnar MR, Kobor MS. Dev Psychopathol. 2016 28(4pt2):1385-1399

DNA methylation signature of human fetal alcohol spectrum disorder. *Portales-Casamar E, *Lussier AA, Jones MJ, MacIsaac JL, Edgar RD, Mah SM, Barhdadi A, Provost S, Lemieux-Perreault LP, Cynader MS, Chudley AE, Dubé MP, Reynolds JN, Pavlidis P, Kobor MS. Epigenetics Chromatin. 2016 9:25
Selected Press Coverage: CBC

Model Organism Research

Neonatal alcohol exposure in mice induces select differentiation- and apoptosis-related chromatin changes both independent of and dependent on sex. Schaffner SL, Lussier AA, Baker JA, Hamre KM, Kobor MS. Front Genet. 2020 11:35

Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA Polymerase II-CTD phosphatase, Fcp1 and Mediator kinase subunit, Cdk8 in yeast. Aristizabal MJ, Dever K, Negri GL, Shen M, Hawe N, Benschop JJ, Holstege FC, Krogran NJ, Sadowski I, Kobor MS. J Biol Chem. 2019 pii: jbc.RA119.008515

Budding yeast Rtt107 prevents checkpoint hyperactivation after replicative stress by limiting DNA damage. Brown JAR, Kobor MS. DNA Repair (Amst). 2019 74:1-16 

Rtt107 BRCT domains act as a targeting module in the DNA damage response. Leung GP, Brown JA, Glover JN, Kobor MS. DNA Repair (Amst). 2016 37:22-32

The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition. Aristizabal MJ, Negri GL, Kobor MS. PLoS Genet. 2015 11(10):e1005608

Prenatal alcohol exposure alters gene expression in the rat brain: Experimental design and bioinformatic analysis of microarray data. Lussier AA, Stepien KA, #Weinberg J, #Kobor MS. Data Brief. 2015 4:239-52

Methods and Tools

CoMeBack: DNA methylation array data analysis for co-methylated regions. Gatev E, Gladish N, Mostafavi S, Kobor MS. Bioinformatics. 2020 36(9):2675-2683

Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation. *Islam SA, *Goodman SJ, MacIsaac JL, Obradović J, Barr RG, Boyce WT, Kobor MS. Epigenetics Chromatin. 2019 12(1):1

Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array. McEwen LM, Jones MJ, Lin DTS, Edgar RD, Husquin LT, MacIsaac JL, Ramadori KE, Morin AM, Rider CF, Carlsten C, Quintana-Murci L, Horvath S, Kobor MS. Clin Epigenetics. 2018 10(1):123

Adjusting for Cell Type Composition in DNA Methylation Data Using a Regression-Based Approach. Jones MJ, Islam SA, Edgar RD, Kobor MS. Methods Mol Biol. 2017 1589:99-106

Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs. Morin AM, Gatev E, McEwen LM, MacIsaac JL, Lin DTS, Koen N, Czamara D, Räikkönen K, Zar HJ, Koenen K, Stein DJ, Kobor MS, Jones MJ. Clin Epigenetics. 2017 9:75

BECon: a tool for interpreting DNA methylation findings from blood in the context of brain. Edgar RD, Jones MJ, Meaney MJ, Turecki G, Kobor MS. Transl Psychiatry. 2017 7(8):e1187
Associated Resource: BECon web application and code

An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs. Edgar RD, Jones MJ, Robinson WP, Kobor MS. Clin Epigenetics. 2017 9:11