{"id":1215,"date":"2023-10-19T19:06:06","date_gmt":"2023-10-19T19:06:06","guid":{"rendered":"https:\/\/bcchrmicro.wpengine.com\/?page_id=1215"},"modified":"2026-01-17T20:54:55","modified_gmt":"2026-01-17T20:54:55","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.bcchr.ca\/tissue-and-disease-modelling-core\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
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\n\t<\/span>\n\tTissue and Disease Modelling Core<\/span><\/a><\/span>News & Events<\/span><\/a><\/span><\/div>\n

Publications<\/h1>

Notable TDMC publications<\/p><\/div>\n

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Notable iPSC-related publications made possible through the TDMC include:<\/h3>

Biggs, C.M., Cordeiro-Santanach, A., Prykhozhij, S.V., Deveau, A.P., Lin, Y., Del Bel, K.L., Orben, F., Ragotte, R.J., Saferali, A., Mostafavi, S., Dinh, L., Dai, D., Weinacht, K.G., Dobbs, K., Ott de Bruin, L., Sharma, M., Tsai, K., Priatel, J.J., Schreiber, R.A., Rozmus, J., Hosking, M.C., Shopsowitz, K.E., McKinnon, M.L., Vercauteren, S., Seear, M., Notarangelo, L.D., Lynn, F.C., Berman, J.N., & Turvey, S.E. (2022)<\/strong>. Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation<\/em><\/a>. JCI Insight<\/strong>, 7(24).<\/p>

Deen, M.C., Zhu, Y., Gros, C., Na, N., Gilormini, P.A., Shen, D.L., Bhosale, S., Anastasi, N., Wang, R., Shan, X., Harde, E., Jagasia, R., Lynn, F.C., & Vocadlo, D.J. (2022)<\/strong>. A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells<\/em><\/a>. Proceedings of the National Academy of Sciences<\/strong>, 119(29), e2200553119.<\/p>

Frew, J., Baradaran-Heravi, A., Balgi, A.D., Wu, X., Yan, T.D., Arns, S., Shidmoossavee, F.S., Tan, J., Jaquith, J.B., Jansen-West, K.R., Lynn, F.C., Gao, F.B., Petrucelli, L., Feldman, H.H., Mackenzie, I.R., Roberge, M., & Nygaard, H.B. (2020)<\/strong>. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency<\/em><\/a>. Molecular Neurodegeneration<\/strong>, 15(1), 21.<\/p>

Krentz, N.A.J., van Hoof, D., Li, Z., Watanabe, A., Tang, M., Nian, C., German, M.S., & Lynn, F.C. (2017)<\/strong>.\u00a0Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors<\/em><\/a>.\u00a0Developmental Cell<\/strong>, 41(2), 129\u2013142.e6.<\/p>

Ooi, J., Langley, S.R., Xu, X., et al. (2019)<\/strong>. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects<\/a>. Cell Reports<\/strong>, 26(9), 2494-2508.e7.<\/p>

Xu, X., Tay, Y., Sim, B., et al. (2017)<\/strong>. Reversal of Phenotypic Abnormalities by CRISPR\/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells<\/em><\/a>. Stem Cell Reports<\/strong>, 8(3), 619\u2013633.<\/p>

Utami, K.H., Skotte, N.H., Cola\u00e7o, A.R., et al. (2020)<\/strong>. Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome<\/em><\/a>. Biological Psychiatry<\/strong>, 88(7), 500\u2013511.<\/p><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_lmt_disableupdate":"","_lmt_disable":"","inline_featured_image":false,"footnotes":"","fndry_alternate_title":"Alternate Title!"},"class_list":["post-1215","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.bcchr.ca\/tissue-and-disease-modelling-core\/wp-json\/wp\/v2\/pages\/1215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bcchr.ca\/tissue-and-disease-modelling-core\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bcchr.ca\/tissue-and-disease-modelling-core\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bcchr.ca\/tissue-and-disease-modelling-core\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bcchr.ca\/tissue-and-disease-modelling-core\/wp-json\/wp\/v2\/comments?post=1215"}],"version-history":[{"count":6,"href":"https:\/\/www.bcchr.ca\/tissue-and-disease-modelling-core\/wp-json\/wp\/v2\/pages\/1215\/revisions"}],"predecessor-version":[{"id":2441,"href":"https:\/\/www.bcchr.ca\/tissue-and-disease-modelling-core\/wp-json\/wp\/v2\/pages\/1215\/revisions\/2441"}],"wp:attachment":[{"href":"https:\/\/www.bcchr.ca\/tissue-and-disease-modelling-core\/wp-json\/wp\/v2\/media?parent=1215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}