{"id":1227,"date":"2022-10-14T20:42:09","date_gmt":"2022-10-14T20:42:09","guid":{"rendered":"https:\/\/bcchrmicro.wpengine.com\/?page_id=2"},"modified":"2026-01-20T00:24:48","modified_gmt":"2026-01-20T00:24:48","slug":"home","status":"publish","type":"page","link":"https:\/\/www.bcchr.ca\/ust1d2\/","title":{"rendered":"Home"},"content":{"rendered":"
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Ustekinumab to Treat Type 1 Diabetes – UST1D2<\/h1>

UST1D2 is a randomized controlled trial exploring the effectiveness of a new medication in people with type 1 diabetes (T1D) aged 18 to 35 years, within 100 days of diagnosis.<\/p><\/a><\/div>\n

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Global News | BC researchers looking for participants in potentially life-changing diabetes research [VIDEO]<\/a><\/h2>

UST1D2 is a randomized controlled trial exploring the effectiveness of a new medication in people with type 1 diabetes (T1D) aged 18 to 35 years, within 100 days of diagnosis.<\/p>

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Aim<\/h2>

We are looking for young adults to help study the effects of a new study medication\u00a0called ustekinumab in young adults recently diagnosed with type 1 diabetes. Ustekinumab is currently used for the treatment of psoriasis (which affects the skin), Crohn’s disease (an inflammatory bowel disease), and other autoimmune conditions.<\/p>

Help us learn if this medication can delay or halt the damage to the pancreas of people recently diagnosed with type 1 diabetes, making it easier to achieve optimal diabetes control in the early years following diagnosis.<\/p>

For this study, we are looking for:<\/strong><\/p>

    \n\tMale or female participants aged 18 to 35 years, diagnosed with T1D<\/li>\n\n\tAbility to receive the first dose of study drug within 100 days of diagnosis of T1D<\/li>\n\n\tEvidence of body still making some insulin (we will measure this)<\/li>\n\n\tAbility to attend 11 study visits over 1.5 years<\/li>\n<\/ul>\n
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    Treatment course and duration<\/h3>

    Before being included in the study, we will perform a screening visit to test if your body is still able to make some insulin. If you choose to participate in the study, you will be randomized to receive either the study medication or a placebo.\u00a0Odds of receiving the study drug is 2\/3 (67%)<\/strong>.<\/p>

    You will be asked to come for a total of 11 study visits, including the screening visit.\u00a0<\/p>

    Study medication or placebo will be administered via IV infusion at a loading given at week 0. Thereafter, study medication or placebo will be injected under the skin at weeks 8, 16, 24, 32, 40, and 48 (seven doses total). Total duration of study is 78 weeks. In order to determine if your body is still able to produce some insulin a two-hour Mixed Meal Tolerance Test (MMTT) will be conducted at screening, week 28, 52, and 78. You will also be asked to provide blood samples at study visits, and you will be asked to complete some questionnaires.<\/p>\n

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    Other notes<\/h3>

    All subjects will be provided Continuous Glucose Monitor (CGM – Dexcom G6) at no charge for the first 12 months of the study.\u00a0Grants to help cover the costs of accommodation and travel to Vancouver or Toronto may be available. (Note: participants local to the Vancouver or Toronto area are not eligible for these grants, but reasonable reimbursement for their other expenses will be provided).<\/p><\/div>\n<\/div><\/div>\n\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_lmt_disableupdate":"","_lmt_disable":"","inline_featured_image":false,"footnotes":"","fndry_alternate_title":""},"class_list":["post-1227","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.bcchr.ca\/ust1d2\/wp-json\/wp\/v2\/pages\/1227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bcchr.ca\/ust1d2\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bcchr.ca\/ust1d2\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bcchr.ca\/ust1d2\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bcchr.ca\/ust1d2\/wp-json\/wp\/v2\/comments?post=1227"}],"version-history":[{"count":37,"href":"https:\/\/www.bcchr.ca\/ust1d2\/wp-json\/wp\/v2\/pages\/1227\/revisions"}],"predecessor-version":[{"id":2474,"href":"https:\/\/www.bcchr.ca\/ust1d2\/wp-json\/wp\/v2\/pages\/1227\/revisions\/2474"}],"wp:attachment":[{"href":"https:\/\/www.bcchr.ca\/ust1d2\/wp-json\/wp\/v2\/media?parent=1227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}