Histopathology
Dolores H Lpez-Terrada and Fleur Webster and Rita Alaggio and Jonathan W Bush and Soo-Jin Cho and Ronald R de Krijger and Takeshi Inoue and Allison F O'Neill and Antonio R Perez-Atayde and Sarangarajan Ranganathan and Jens Stahlschmidt and Yukichi Tanaka and Marta Cohen and Miguel Reyes-Mgica
DOI: 10.1111/his.1553612 / 2025
Journal of the Canadian Association of Gastroenterology
Vishal Avinashi and Milli Gupta and Beth A Payne and Haneen Amhaz and Alisha T Temirova and Waqqas Afif and Dhandapani Ashok and Janice Barkey and David Burnett and Jonathan W Bush and Scott Cameron and Stuart Carr and Dina El Demellawy and Stephanie Erdle and Hien Q Huynh and Jennifer Griffin and Samir C Grover and Kelly Grzywacz and Samira Jeimy and Hin Hin Ko and Gina Lacuesta and Margaret Marcon and Serge Mayrand and Harrison Petropolis and David Rodrigues and Mary Sherlock and Christine Song and Natacha Tardio and Timothy K Vander Leek and Meagan Vurzinger and Brock Williams and Ted Xenodemetroupolous and Christopher Ma and Edmond S Chan
DOI: 10.1093/jcag/gwaf02212 / 2025
Marco Marra and Dan Jin and Joshua Dubland and Elizabeth Mullen and James Geller and Jonathan Bush
DOI: 10.21203/rs.3.rs-7303174/v108 / 2025
PLOS ONE
Sebastian Kondratowski and Danielle Cohen and Rebecca J. Deyell and Ash Sandhu and Jonathan W. Bush
DOI: 10.1371/journal.pone.030947111 / 2024
Applied immunohistochemistry & molecular morphology : AIMM
Wang XQ and Tessier-Cloutier B and Saunders J and Harvey M and Armstrong L and Ng T and Dunham C and Bush JW
DOI: 10.1097/pai.0000000000001122 PubMed: 3703640804 / 2023
Analytical chemistry
Barnabas GD and Verena Goebeler and Tsui J and Bush JW and Philipp F. Lange
DOI: 10.1021/acs.analchem.2c04264 PubMed: 3672407002 / 2023
Experimental hematology & oncology
Nierves L and Guo J and Chen S and Tsui J and Uzozie AC and Bush JW and Huan T and Lange PF
DOI: 10.1186/s40164-022-00310-0 PubMed: 3610980409 / 2022
Fetal and pediatric pathology
Cruz J and Michael Irvine and Vishal Avinashi and Edmond Chan and Vallance BA and Lianne Soller and Bruce Vallance
DOI: 10.1080/15513815.2022.2028950 PubMed: 3509466101 / 2022
Pediatric and Developmental Pathology
Jessica Saunders and Allison Marie Callejas Salgado and Joseph Y Ting and Cherry Mammen and Jefferson Terry and Jonathan W Bush
DOI: 10.1177/1093526621101892209 / 2021
The Journal of Pathology
Mamy Andrianteranagna and Joanna Cyrta and Julien Masliah-Planchon and Karolina Nemes and Alice Corsia and Amaury Leruste and Drthe Holdhof and Uwe Kordes and Daniel Orbach and Nadge Corradini and Natacha Entz-Werle and Galle Pierron and Marie-Pierre Castex and Anne Brouchet and Nolle Weingertner and Dominique Ranchre and Paul Frneaux and Olivier Delattre and Jonathan Bush and Alexandra Leary and Michael C. Frhwald and Ulrich Schller and Nicolas Servant and Franck Bourdeaut
DOI: 10.1002/path.570505 / 2021
Acta Neuropathologica
Drthe Holdhof and Pascal D. Johann and Michael Spohn and Michael Bockmayr and Sepehr Safaei and Piyush Joshi and Julien Masliah-Planchon and Ben Ho and Mamy Andrianteranagna and Franck Bourdeaut and Annie Huang and Marcel Kool and Santhosh A. Upadhyaya and Anne E. Bendel and Daniela Indenbirken and William D. Foulkes and Jonathan W. Bush and David Creytens and Uwe Kordes and Michael C. Frhwald and Martin Hasselblatt and Ulrich Schller
DOI: 10.1007/s00401-020-02250-7Dysphagia
Avinashi V and Chan JM and Bush JW and Vallance BA and Yang H and Portales-Casamar E and Soller L and Mill C and Chan ES
DOI: 10.1007/s00455-019-10082-1 PubMed: 3177333211 / 2019
Fetal and Pediatric Pathology
Cyrus L Matheson and Geoffrey K Blair and Jonathan Bush
DOI: 10.1080/15513815.2019.160062509 / 2019
Journal of Clinical Immunology
Jessica R. Saunders and Anna Lehman and Stuart E. Turvey and Jie Pan and Evica Rajcan-Separovic and Aleixo M. Muise and Jonathan W. Bush
DOI: 10.1007/s10875-019-00669-608 / 2019
JCI insight
Nicholas Dawson and Caroline Lamarche and Hoeppli RE and Bergqvist P and Fung VC and McIver E and Huang Q and Gillies J and Speck M and Orban PC and Jonathan Bush and Mojibian M and Megan K. Levings
DOI: 10.1172/jci.insight.123672 PubMed: 3075316903 / 2019
Journal of pediatric gastroenterology and nutrition
Mohammad N and Vishal Avinashi and Chan E and Bruce Vallance and Elodie Portales-Casamar and Jonathan Bush
DOI: 10.1097/mpg.0000000000001949 PubMed: 2950963308 / 2018
Pediatric and Developmental Pathology
Singh, V. and Eldin, K. and Timmons, C. and Bush, J. and Rabah, R.
DOI: 10.1177/1093526617722905Pediatric Transplantation
Bush, J.W. and Mohammad, S. and Melin-Aldana, H. and Kagalwalla, A.F. and Arva, N.C.
DOI: 10.1111/petr.12693Pediatric Blood and Cancer
Armstrong, A.E. and Weese-Mayer, D.E. and Mian, A. and Maris, J.M. and Batra, V. and Gosiengfiao, Y. and Reichek, J. and Madonna, M.B. and Bush, J.W. and Shore, R.M. and Walterhouse, D.O.
DOI: 10.1002/pbc.25572Journal of Pediatric Urology
Bowen, D.K. and Glaser, A.P. and Bush, J.W. and Cheng, E.Y. and Gong, E.M.
DOI: 10.1016/j.jpurol.2014.11.009Journal of Hematopathology
Weinstein, J.L. and Badawy, S.M. and Bush, J.W. and Schafernak, K.T.
DOI: 10.1007/s12308-015-0254-3Pediatric and Developmental Pathology
Bush, J.W. and Hancock, B.J. and Israels, S.J. and Ellison, D.W. and Stefanovici, C. and Krawitz, S.
DOI: 10.2350/14-01-1427-CR.1Diagnostic Microbiology and Infectious Disease
Bush, J.W. and Wuerz, T. and Embil, J.M. and Del Bigio, M.R. and McDonald, P.J. and Krawitz, S.
DOI: 10.1016/j.diagmicrobio.2013.03.002Rhabdoid tumors are a group of primitive cancers that are often highly aggressive and are generally defined by a mutation in the SWI/SNF pathway, including the genes SMARCB1 (INI1) and SMARCA4 (BRG1). The Bush lab was one of the first groups to explore the use of BRG1 IHC to identify a subset of RTs that were INI1-retained. Further work is ongoing looking at the immune microenvironment of RTs as these are generally considered to have low tumor mutational burden and thus are immune-cold tumors, yet there appears to be heterogenous areas of tumor cell infiltration. Utilizing spatial genomics and proteomics, we hope to better understand RT inter and intra-tumoral heterogeneity.
The Bush lab uses fresh and fixed tumor tissue from the two most common malignant bone tumors, Osteosarcoma (OS) and Ewing Sarcoma (ES), to explore novel antibodies using immunohistochemistry (IHC) for diagnosis and prognosis. This includes developing tissue microarrays (TMAs) to test a number of antibodies across a wide variety of samples. Some work has shown that a particular methylation pattern in the diagnostic biopsies of OS may predict good or bad disease behaviour.
Working with collaborators, the Bush lab is helping to establish a proteomics pipeline that will demonstrate the utility of proteomics in clinical applications. This includes providing diagnostic, prognostic, and in some cases predictive markers that will allow for personalized therapies based on relative over or under-abundance of particular proteins. Promising results have been seen in OS and neuroblastoma to date. In collaboration with researchers at UBC and the NIH, the Bush lab is exploring the use of machine learning (ML) in osteosarcoma. This work will develop a pipeline for assessing tissue quality for the purpose of molecular studies, facilitate histologic classification of OS for clinical trials, and to explore potential prognostic markers as identified by supervised and unsupervised ML. The Bush lab has worked with collaborators in establishing a novel method of developing patient-derived xenografts using a less expensive model than the typical mouse system. Through this chorioallantoic membrane (CAM) modelling system, we have been able to facilitate tumor expansion in both highly aggressive and indolent tumors, and have worked to demonstrate the utility of the CAM system for drug testing.
Our group was the first to show that pediatric EoE was associated with increased lamina propria IgG4-positive plasma cells, which is being explored as to whether food-specific IgG4 can be used to evaluate for EoE disease activity. Ongoing work by the Bush lab has included utilizing novel techniques to evaluate EoE slides as well as potential spatial differences between the immune and squamous cell compartments.
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BC Children's Hospital Research Institute operates on the ancestral and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. Further, this acknowledgement, gratitude, and respect extends to all of the First Nations communities on whose territories the Research Institute builds relationships and operates in British Columbia.
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