Laura Sauvé

MPH, MD

Investigator, BC Children's Hospital

Dr. Laura Sauvé is a Clinical Assistant Professor and a pediatric infectious disease specialist who has a special interest in Pediatric HIV/AIDS.

Her main research interests include public health surveillance especially with respect to vaccinology, vaccine preventable disease, global child health and pediatric HIV/AIDS.

She joined the Vaccine Evaluation Center in 2007 as the BC site investigator for the Immunization Monitoring Program, Active (IMPAct), a national surveillance system for vaccine preventable diseases and vaccine adverse events in 12 pediatric tertiary care centers across Canada.

She is also the co-primary investigator of the Canadian Perinatal HIV Surveillance Program, which studies vertical transmission of HIV across Canada. As Pediatrics Residency Program Director, she is also involved in a number of medical education research initiatives.

Academic Affiliations

  • Clinical Assistant Professor, Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Healthy Starts
  • Research Group(s): Global Health and Innovations; Vaccines, Infections, and Host Defenses

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

Pediatricians response to presenting formula and breast- or chestfeeding as equivalent options for parents with virally suppressed HIV

CMAJ Canadian Medical Association Journal

Khan, S. and Brophy, J. and Kakkar, F. and Nashid, N. and Sauve, L. and Purewal, R. and Bitnun, A.

DOI: 10.1503/cmaj.152179-l

Child Transmission of SARS-CoV-2 Throughout the Pandemic: An Updated Systematic Review and Meta-analysis

Pediatric Infectious Disease Journal

Kwon, E. and Blank, G. and Starkey, S. and Chapman, C. and Lategan, C. and Shulha, H. and Kitchin, V. and Silverberg, S. and Sauv{\'e}, L. and Sadarangani, M.

DOI: 10.1097/INF.0000000000004733

ASXL1 deficiency causes epigenetic dysfunction, combined immunodeficiency, and EBV-associated lymphoma

Journal of Experimental Medicine

Fu, M.P. and Sharma, M. and Yousefi, P. and Merrill, S.M. and Tan, R. and Samra, S. and Setiadi, A. and Golding, L. and Modi, B.P. and Del Bel, K.L. and Deyell, R.J. and Rozmus, J. and Rehmus, W. and Hildebrand, K.J. and James, E. and Blanchard-Rohner, G. and Lin, S. and Shopsowitz, K.E. and Terry, J. and Lee, A.F. and Dr{\"o}gem{\"o}ller, B.I. and Matthews, A. and Tarailo-Graovac, M. and Sauv{\'e}, L. and Mitchell, H. and Prendiville, J.S. and MacIsaac, J.L. and Dever, K. and Lin, D.T.S. and Meijer, M. and Ross, C.J.D. and Dobson, S.R.M. and Vercauteren, S.M. and Wasserman, W.W. and van Karnebeek, C.D.M. and McKinnon, M.L. and Kobor, M.S. and Turvey, S.E. and Biggs, C.M.

DOI: 10.1084/jem.20240945

Active Surveillance for Myocarditis and Pericarditis in Canadian Children from 2021 to 2022: A Canadian Immunization Monitoring Program ACTive Study

Journal of Pediatrics

Top, K.A. and Bettinger, J.A. and Embree, J.E. and Jadavji, T. and Purewal, R. and Sauv{\'e}, L. and Papenburg, J. and Deeks, S.L. and Wilson, S.E. and Dahdah, N. and Sadarangani, M. and Halperin, S.A. and Kakkar, F. and Morris, S.K.

DOI: 10.1016/j.jpeds.2025.114642

Clinical and Immunologic Impact of CMV Coinfection among Children Living with HIV in Canada

Pediatric Infectious Disease Journal

Foug{\`e}re, Y. and Brophy, J. and Hawkes, M.T. and Lee, T. and Samson, L. and Gantt, S. and Dufour, M.-S.K. and Renaud, C. and Dieumegard, H. and Diallo, M.A. and Canape, J. and Read, S. and Bitnun, A. and Soudeyns, H. and Kakkar, F. and Alimenti, A. and Ancuta, P. and Bullard, J. and Chun, T.-W. and C{\^o}t{\'e}, H.C.F. and Embree, J. and Karatzios, C. and Kaul, R. and Kim, J. and Lamarre, V. and Lapointe, N. and Lavoie, P. and Money, D.M. and Moore, D. and Reinhard, R. and Sandstorm, P. and Sauve, L. and Seigel, S. and Singer, J. and Tan, B. and Vaudry, W.

DOI: 10.1097/INF.0000000000004811

Streptococcus pneumoniae-associated hemolytic uremic syndrome Canadian Immunization Monitoring Program ACTive National Pediatric Surveillance (1991 to 2019)

Paediatrics and Child Health Canada

Lee, L.D. and Vadlamudi, N.K. and Yu, K. and Sadarangani, M. and Le Saux, N. and Embree, J. and Kellner, J.D. and Morris, S.K. and Halperin, S.A. and Betinger, J.A. and Bridger, N. and Foo, C. and Halperin, S.A. and Top, K.A. and Tibeault, R. and Papenburg, J. and Lebel, M. and Le Saux, N. and Morris, S. and Embree, J. and Tan, B. and McConnell, A. and Jadavji, T. and Constantinescu, C. and Vaudry, W. and Scheifele, D. and Sadarangani, M. and Sauv{\'e}, L.

DOI: 10.1093/pch/pxae055

Postnatal prophylaxis and the use of presumptive HIV therapy for the prevention of vertical transmission of HIV in Canada 1997"2020

Journal of the International AIDS Society

Brochon, J. and Lee, T. and Brophy, J. and Singer, J. and Metras, M.-E. and Comeau, J. and Tse-Chang, A. and McConnell, A. and Money, D. and Boucoiran, I. and Sauve, L.J. and Bitnun, A. and Kakkar, F.

DOI: 10.1002/jia2.26510

Severity of COVID-19 in Hospitalized Immunocompromised Children Across Canada

Pediatric Infectious Disease Journal

Di Chiara, C. and Schober, T. and Farrar, D.S. and Bettinger, J.A. and Drouin, O. and Embree, J.E. and Halperin, S.A. and Moore Hepburn, C. and Jadavji, T. and Kazmi, K. and Purewal, R. and Sadarangani, M. and Sauv{\'e}, L. and Top, K.A. and Kakkar, F. and Papenburg, J. and Morris, S.K. and Bridger, N. and Bullard, J. and Burton, C. and Campigotto, A. and Chawla, R. and Comeau, J. and Constantinescu, C. and Deeks, S.L. and Embree, J.E. and Haddad, E. and Halperin, S.A. and Jadavji, T. and Kakkar, F. and King, M. and Le Saux, N. and Lebel, M.H. and Papenburg, J. and Pernica, J.M. and Thibeault, R. and Yeung, R.S.M.

DOI: 10.1097/INF.0000000000004856

Pediatric COVID-19 severity by SARS-CoV-2 lineage and vaccine status in Canada: an IMPACT study

Pediatric Research

Farrar, D.S. and Bettinger, J.A. and Campigotto, A.J. and Deeks, S.L. and Drouin, O. and Embree, J.E. and Haddad, E. and Halperin, S.A. and Jadavji, T. and Kazmi, K. and King, M. and Moore Hepburn, C. and Papenburg, J. and Purewal, R. and Sadarangani, M. and Sauv{\'e}, L. and Yeung, R.S.M. and Top, K.A. and Kakkar, F. and Morris, S.K.

DOI: 10.1038/s41390-025-03853-0

Knowledge gaps and research priorities regarding vaccination in pregnancy: A Canadian perspective from the prevention of infections in the maternal-infant dyad (PRIMED) consortium

Vaccine

Hunter, O.F. and McClymont, E. and Lau, O. and Bettinger, J.A. and Castillo, E. and Crowcroft, N.S. and Dub{\'e}, ?. and Elwood, C. and Gantt, S. and Halperin, S.A. and Langley, J.M. and Money, D. and Naus, M. and Sauv{\'e}, L. and Top, K.A. and van Schalkwyk, J. and Sadarangani, M.

DOI: 10.1016/j.vaccine.2025.127594

Sexually transmitted infections and bacterial vaginosis and preterm birth in pregnant people living with HIV: A population-based cohort study

International Journal of STD and AIDS

Wong, J.M.H. and Av-Gay, G. and Lee, T. and Azampanah, A. and Elwood, C. and van Schalkwyk, J. and Sauv{\'e}, L. and Money, D.

DOI: 10.1177/09564624251347458

Perinatal and early infant outcomes after bictegravir exposure in pregnancy: a Canadian surveillance study

Journal of Acquired Immune Deficiency Syndromes 1999

Wong, J.M.H. and Balleny, R. and Lee, T. and Bitnun, A. and Boucoiran, I. and Brophy, J. and Comeau, J. and Kakkar, F. and McConnell, A. and Sauv{\'e}, L. and Singer, J. and Tse-Chang, A. and Money, D.

DOI: 10.1097/QAI.0000000000003708

EPIDEMIOLOGY OF FEBRILE SEIZURES DURING THE COVID-19 PANDEMIC: A CANADIAN IMMUNIZATION MONITORING PROGRAM-ACTIVE (IMPACT) STUDY

Pediatric Infectious Disease Journal

Top, K.A. and Shulha, H.P. and Hassan, F. and Sauv{\'e}, L. and Jadavji, T. and Purewal, R. and Constantinescu, C. and Sadarangani, M. and Halperin, S.A. and Morris, S.K. and Bettinger, J.A. and Comeau, J. and Thibeault, R. and Kazmi, K. and Bullard, J. and Le Saux, N. and Papenburg, J. and Bridger, N. and Lebel, M. and Kakkar, F. and Chawla, R. and Burton, C. and Pernica, J.M.

DOI: 10.1097/INF.0000000000004759

Bloodstream Infections in Children Hospitalized for Influenza, the Canadian Immunization Monitoring Program Active

Pediatric Infectious Disease Journal

Modler, J. and Morris, S.K. and Bettinger, J.A. and Bancej, C. and Burton, C. and Foo, C. and Halperin, S.A. and Jadavji, T. and Kazmi, K. and Sadarangani, M. and Schober, T. and Papenburg, J. and Bridger, N. and Top, K. and Thibeault, R. and Moore, D.L. and Lebel, M. and Saux, N.L. and Purewal, R. and Sauv, L. and Bullard, J.

DOI: 10.1097/INF.0000000000004199

Lower Neutrophil Count Without Clinical Consequence among Children of African Ancestry Living with HIV in Canada

Journal of Acquired Immune Deficiency Syndromes

Bernard, I. and Ransy, D.G. and Brophy, J. and Kakkar, F. and Bitnun, A. and Sauv, L. and Samson, L. and Read, S. and Soudeyns, H. and Hawkes, M.T. and Alimenti, A. and Ancuta, P. and Bitnun, A. and Brophy, J. and Bullard, J. and Chun, T.-W. and Ct, H.C.F. and Embree, J. and Hawkes, M.T. and Kakkar, F. and Karatzios, C. and Kaul, R. and Kim, J. and Lamarre, V. and Lapointe, N. and Lavoie, P. and Lee, T. and Money, D.M. and Moore, D. and Read, S. and Reinhard, R. and Samson, L. and Sandstorm, P. and Sauve, L. and Seigel, S. and Singer, J. and Soudeyns, H. and Tan, B. and Vaudry, W.

DOI: 10.1097/QAI.0000000000003467

Diagnosis and management of congenital syphilis: Avoiding missed opportunities,Le diagnostic et la prise en charge de la syphilis congnitale: ne laisser passer aucune occasion

Paediatrics and Child Health Canada

Fanella, S. and Bitnun, A. and Barton, M. and Sauv{\'e}, L.

DOI: 10.1093/pch/pxae040

Reimagining congenital cytomegalovirus care in British Columbia

British Columbia Medical Journal

Benson, N. and Sauv{\'e}, L. and Elwood, C. and Ziabakhsh, S.

Hepatitis B prophylaxis of infants born to mothers with no antenatal care: Understanding the nuances in Canada

Paediatrics and Child Health (Canada)

Bitnun, A. and Baron-Forbes, M. and Sauv, L. and Fanella, S.

DOI: 10.1093/pch/pxad092

Retrospective Cohort Study on the Impact of the COVID-19 Pandemic on Pregnancy Outcomes for Women Living With HIV in British Columbia

Journal of Acquired Immune Deficiency Syndromes

Fu, W. and McClymont, E. and Av-Gay, G. and Dorling, M. and Atkinson, A. and Azampanah, A. and Elwood, C. and Sauv, L. and Van Schalkwyk, J. and Sotindjo, T. and Money, D.

DOI: 10.1097/QAI.0000000000003384

Factors associated with SARS-CoV-2 infection in unvaccinated children and young adults

BMC Infectious Diseases

Silverberg, S.L. and Shulha, H.P. and McMillan, B. and He, G. and Lee, A. and Mrquez, A.C. and Bartlett, S.R. and Gill, V. and Abu-Raya, B. and Bettinger, J.A. and Cabrera, A. and Coombs, D. and Gantt, S. and Goldfarb, D.M. and Sauv, L. and Krajden, M. and Morshed, M. and Sekirov, I. and Jassem, A.N. and Sadarangani, M.

DOI: 10.1186/s12879-023-08950-1

Diagnosis and management of congenital syphilis: Avoiding missed opportunities

Paediatrics and Child Health Canada

Fanella, S. and Bitnun, A. and Barton, M. and Sauv{\'e}, L.

DOI: 10.1093/pch/pxae044

Comparison of Maternal and Infant Outcomes in SARS-CoV-2 Infected Pregnancies and Contemporaneous General Population Pregnancies From British Columbia

Journal of Obstetrics and Gynaecology Canada

Fu, W. and McClymont, E. and Av-Gay, G. and Zhang, Q. and Bone, J.N. and Elwood, C. and Roberts, A. and Sadarangani, M. and Sauv, L. and van Schalkwyk, J. and Money, D.

DOI: 10.1016/j.jogc.2024.102631

Chronic and Latent Viral Infections and Leukocyte Telomere Length across the Lifespan of Female and Male Individuals Living with or without HIV

Viruses

Yang, N.Y. and Hsieh, A.Y.Y. and Chen, Z. and Campbell, A.R. and Gadawska, I. and Kakkar, F. and Sauve, L. and Bitnun, A. and Brophy, J. and Murray, M.C.M. and Pick, N. and Krajden, M. and Ct, H.C.F.

DOI: 10.3390/v16050755

Outcomes of immunocompromised children hospitalized for Influenza, 2010-2021, the Canadian Immunization Monitoring Program Active (IMPACT)

Clinical Microbiology and Infection

Schober, T. and Morris, S.K. and Bettinger, J.A. and Bancej, C. and Burton, C. and Foo, C. and Halperin, S.A. and Jadavji, T. and Kazmi, K. and Modler, J. and Sadarangani, M. and Papenburg, J. and Bridger, N. and Top, K. and Thibeault, R. and Lebel, M. and Le Saux, N. and Bullard, J. and Purewal, R. and Sauv, L.

DOI: 10.1016/j.cmi.2023.04.001

Reducing perinatal infection risk in newborns of mothers who received inadequate prenatal care,La rduction du risque d'infection prinatale chez les nouveau-ns de mres dont les soins prnatals taient inappropris

Paediatrics and Child Health (Canada)

Bitnun, A. and Sauv, L. and Fanella, S.

DOI: 10.1093/pch/pxad015

Prescribing patterns of antiretroviral treatments during pregnancy for women living with HIV in Canada 2004"2020: A surveillance study

HIV Medicine

Carvalho, S. and Lee, T. and Tulloch, K.J. and Sauve, L.J. and Samson, L. and Brophy, J.C. and Bitnun, A. and Singer, J. and Money, D. and Kakkar, F. and Boucoiran, I.

DOI: 10.1111/hiv.13346

Factors associated with severe acute respiratory syndrome-related coronavirus 2 infection in unvaccinated children and young adults

medRxiv

Silverberg, S.L. and Shulha, H.P. and McMillan, B. and He, G. and Lee, A. and Mrquez, C. and Bartlett, S.R. and Gill, V. and Abu-Raya, B. and Bettinger, J.A. and Cabrera, A. and Coombs, D. and Gantt, S. and Goldfarb, D.M. and Sauv, L. and Krajden, M. and Morshed, M. and Sekirov, I. and Jassem, A.N. and Sadarangani, M.

DOI: 10.1101/2023.08.13.23294036

Reducing perinatal infection risk in newborns of mothers who received inadequate prenatal care

Paediatrics and Child Health (Canada)

Bitnun, A. and Sauv, L. and Fanella, S.

DOI: 10.1093/pch/pxad014

Drinking Water From Private Wells and Risks to Children

Pediatrics

Woolf, A.D. and Stierman, B.D. and Barnett, E.D. and Byron, L.G. and Bole, A. and Balk, S.J. and Byron, L.G. and Huerta-Montaez, G.M. and Landrigan, P.J. and Marcus, S.M. and Nerlinger, A.L. and Patel, L.H. and Philipsborn, R. and Woolf, A.D. and Zajac, L. and Gray, K.A. and Briskin, J. and DeNicola, N.G. and Karwowski, M. and Briggs, A. and Ward, M.H. and Spire, P. and Maldonado, Y.A. and O?Leary, S.T. and Ardura, M.I. and Banerjee, R. and Bryant, K.A. and Campbell, J.D. and Caserta, M.T. and John, C.C. and Gerber, J.S. and Kourtis, A.P. and Ratner, A.J. and Romero, J.R. and Shah, S.S. and Zangwill, K.M. and Kimberlin, D.W. and Barnett, E.D. and Lynfield, R. and Sawyer, M.H. and Bernstein, H.H. and Farizo, K.M. and Kafer, L.M. and Kim, D. and Medina, E.L. and Moore, D. and Panagiotakopoulos, L. and Sauv, L. and Silverman, N.S. and Starke, J.R. and Tomashek, K.M. and Wharton, M. and Frantz, J.M.

DOI: 10.1542/peds.2022-060645

Human ASXL1 Deficiency Causes Epigenetic Dysfunction, Combined Immunodeficiency and EBV"Associated Hodgkin Lymphoma

medRxiv

Fu, M.P. and Sharma, M. and Merrill, S.M. and Yousefi, P. and Tan, R. and Modi, B.P. and Bel, K.D. and Deyell, R.J. and Rozmus, J. and Rehmus, W. and Hildebrand, K.J. and James, E. and Blanchard-Rohner, G. and Lin, S. and Shopsowitz, K.E. and Setiadi, A. and Terry, J. and Lee, A.F. and Drgemller, B.I. and Matthews, A. and Tarailo-Graovac, M. and Sauv, L. and Mitchell, H. and Prendiville, J.S. and MacIsaac, J.L. and Dever, K. and Lin, D.T.S. and Meijer, M. and Ross, C.J.D. and Dobson, S.R.M. and Vercauteren, S.M. and Wasserman, W.W. and van Karnebeek, C.D.M. and McKinnon, M.L. and Kobor, M.S. and Turvey, S.E. and Biggs, C.M.

DOI: 10.1101/2023.12.20.23300096

Type and timing of antiretroviral therapy during pregnancy: Impact on risk of preterm delivery and small-for-gestational age births in Canada, a retrospective cohort study

International Journal of Gynecology and Obstetrics

Schneidman, J. and Lee, T. and Sauve, L. and Brophy, J. and Bitnun, A. and Singer, J. and Money, D. and Kakkar, F. and Boucoiran, I.

DOI: 10.1002/ijgo.14705

Kawasaki disease following immunization reported to the Canadian Immunization Monitoring Program ACTive (IMPACT) from 2013 to 2018

Human Vaccines and Immunotherapeutics

Alsager, K. and Khatri Vadlamudi, N. and Jadavji, T. and Bettinger, J.A. and Constantinescu, C. and Vaudry, W. and Tan, B. and Sauv{\'e}, L. and Sadarangani, M. and Halperin, S.A. and Top, K.A.

DOI: 10.1080/21645515.2022.2088215

Higher Hospitalization Rates in Children Born HIV-exposed Uninfected in British Columbia, Canada, Between 1990 and 2012

Pediatric Infectious Disease Journal

Li, S.N.J. and Albert, A. and Piske, M. and Janssen, P.A. and Alimenti, A. and Jesson, J. and Ct, H.C.F. and Sauv, L.

DOI: 10.1097/INF.0000000000003365

The effect of the COVID-19 pandemic on influenza-related hospitalization, intensive care admission and mortality in children in Canada: A population-based study

The Lancet Regional Health - Americas

Groves, H.E. and Papenburg, J. and Mehta, K. and Bettinger, J.A. and Sadarangani, M. and Halperin, S.A. and Morris, S.K. and Bancej, C. and Burton, C. and Embree, J. and Foo, C. and Bridger, N. and Morris, R. and Jadavji, T. and Lebel, M. and Le Saux, N. and Top, K.A. and Tan, B. and McConnell, A. and Purewal, R. and Dry, P. and Thibeault, R. and Vaudry, W. and Tran, D. and Sauv, L. and Moore, D.L. and Lefebvre, M.-A.

DOI: 10.1016/j.lana.2021.100132

COVID-19 Vaccines in Children and Adolescents

Pediatrics

Maldonado, Y.A. and O{'}Leary, S.T. and Ardura, M.I. and Banerjee, R. and Bryant, K.A. and Campbell, J.D. and Caserta, M.T. and John, C.C. and Gerber, J.S. and Kourtis, A.P. and Ratner, A.J. and Romero, J.R. and Shah, S.S. and Zangwill, K.M. and Kimberlin, D.W. and Barnett, E.D. and Lynfield, R. and Sawyer, M.H. and Bernstein, H.H. and Cohn, A.C. and Farizo, K.M. and Halasa, N.B. and Kafer, L.M. and Kim, D. and L{\'o}pez Medina, E. and Moore, D. and Panagiotakopoulos, L. and Sauv{\'e}, L. and Silverman, N.S. and Starke, J.R. and Tomashek, K.M. and Frantz, J.M.

DOI: 10.1542/peds.2021-054332

Child transmission of SARS-CoV-2: a systematic review and meta-analysis

BMC Pediatrics

Silverberg, S.L. and Zhang, B.Y. and Li, S.N.J. and Burgert, C. and Shulha, H.P. and Kitchin, V. and Sauv, L. and Sadarangani, M.

DOI: 10.1186/s12887-022-03175-8

The changing epidemiology of syphilis in BC

British Columbia Medical Journal

Wong, J. and Murray, M. and Sauv{\'e}, L. and Chan, E. and Schalkwyk, J. and Pederson, A. and Giesbrecht, E. and Morgan, M. and Morshed, M. and Grennan, T.

Clinical Presentations and Outcomes of Children in Canada with Recurrent Invasive Pneumococcal Disease from the IMPACT Surveillance Network

Pediatric Infectious Disease Journal

Murad, Y. and Hung, T.-Y. and Sadarangani, M. and Morris, S.K. and Le Saux, N. and Vanderkooi, O.G. and Kellner, J.D. and Tyrrell, G.J. and Martin, I. and Demczuk, W. and Halperin, S.A. and Bettinger, J.A. and Bridger, N. and Foo, C. and Halperin, S.A. and Top, K.A. and Thibeault, R. and Moore, D. and Papenburg, J. and Lebel, M. and Le Saux, N. and Morris, S. and Embree, J. and Tan, B. and McConnell, A. and Jadavji, T. and Constantinescu, C. and Vaudry, W. and Scheifele, D. and Sadarangani, M. and Bettinger, J. and Sauv, L.

DOI: 10.1097/INF.0000000000003454

Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis

International Journal of Infectious Diseases

Boyan K. Tsankov and Joannie M. Allaire and Michael A. Irvine and Alison A. Lopez and Laura J. Sauv and Bruce A. Vallance and Kevan Jacobson

DOI: 10.1016/j.ijid.2020.11.163

02 / 2021

Epidemiology, clinical features and outcomes of incident tuberculosis in children in Canada in 2013"2016: results of a national surveillance study

Archives of Disease in Childhood

Morris, S.K. and Giroux, R.J.P. and Consunji-Araneta, R. and Stewart, K. and Baikie, M. and Kakkar, F. and Zielinski, D. and Tse-Chang, A. and Cook, V.J. and Fisher, D.A. and Salvadori, M.I. and Pernica, J.M. and Sauve, L.J. and Hui, C. and Miners, A. and Alvarez, G.G. and Al-Azem, A. and Gallant, V. and Grueger, B. and Lam, R. and Langley, J.M. and Radziminski, N. and Rea, E. and Wong, S. and Kitai, I.

DOI: 10.1136/archdischild-2021-322092

Preterm Birth and Antiretroviral Exposure in Infants HIV-exposed Uninfected

Pediatric Infectious Disease Journal

Piske, M. and Qiu, A.Q. and Maan, E.J. and Sauv, L.J. and Forbes, J.C. and Alimenti, A. and Janssen, P.A. and Money, D.M. and Ct, H.C.F.

DOI: 10.1097/INF.0000000000002984

Recommended childhood and adolescent immunization schedule: United States, 2021

Pediatrics

Maldonado, Y.A. and O{'}Leary, S.T. and Banerjee, R. and Campbell, J.D. and Caserta, M.T. and Gerber, J.S. and Kourtis, A.P. and Lynfield, R. and Munoz, F.M. and Nolt, D. and Ratner, A. and Shah, S.S. and Steinbach, W.J. and Zangwill, K.M. and Zaoutis, T.E. and Kimberlin, D.W. and Barnett, E.D. and Sawyer, M.H. and Bernstein, H.H. and Meissner, H.C. and Cohn, A.C. and Farizo, K.M. and Halasa, N.B. and Kim, D. and Medina, E.L. and Moore, S.B. and Panagiotakopoulos, L. and Sauv{\'e}, L. and Silverman, N.S. and Starke, J.R. and Stevermer, J.J. and Tomashek, K.M. and Frantz, J.M.

DOI: 10.1542/PEDS.2020-049775

Answer to Photo Quiz: Bertiella studeri Infection

Journal of Clinical Microbiology

Panchmatia, R. and Whellams, D. and Valent, N. and Sauve, L.

DOI: 10.1128/JCM.00840-20

Photo Quiz: A 6-Year-old immigrant with abdominal pain

Journal of Clinical Microbiology

Panchmatia, R. and Whellams, D. and Valent, N. and Sauv, L.

DOI: 10.1128/JCM.00839-20

Women in the 2019 hepatitis C cascade of care: findings from the British Columbia Hepatitis Testers cohort study

BMC Women's Health

Pearce, M.E. and Bartlett, S.R. and Yu, A. and Lamb, J. and Reitz, C. and Wong, S. and Alvarez, M. and Binka, M. and Velsquez Garcia, H. and Jeong, D. and Clementi, E. and Adu, P. and Samji, H. and Wong, J. and Buxton, J. and Yoshida, E. and Elwood, C. and Sauve, L. and Pick, N. and Krajden, M. and Janjua, N.Z.

DOI: 10.1186/s12905-021-01470-7

Canadian surveillance of COVID-19 in pregnancy: Epidemiology and maternal and infant outcomes

American journal of obstetrics and gynecology

McClymont E and Fell D and Albert A and Alton G and Barrett J and El-Chaar D and Harrold J and Krajden M and Lipsky N and Maan E and Malinowski A and Othman M and Raeside A and Ray J and Money D

11 / 2020

Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time.

Aging

Hsieh AYY and Kimmel E and Pick N and Sauv L and Brophy J and Kakkar F and Bitnun A and Murray MCM and Ct HCF

DOI: 10.18632/aging.103703 PubMed: 32703912

07 / 2020

Review of pediatric encephalitis and encephalopathy cases following immunization reported to the Canadian Immunization Monitoring Program Active (IMPACT) from 1992 to 2012.

Vaccine

Tam J and Tran D and Bettinger JA and Moore D and Sauv L and Jadavji T and Tan B and Vaudry W and Halperin SA and Top KA and Canadian Immunization Monitoring Program Active Investigators

DOI: 10.1016/j.vaccine.2020.04.035 PubMed: 32414652

05 / 2020

Challenges to achieving and maintaining viral suppression among children living with HIV.

AIDS (London, England)

Kakkar F and Lee T and Hawkes MT and Brophy J and Lindy S and Singer J and Dieumegard H and Sauve L and Alimenti A and Vaudry W and Seigel S and Tan B and Karatzios C and Lamarre V and EPIC4 Study Group

DOI: 10.1097/qad.0000000000002454 PubMed: 31794519

04 / 2020

Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era, 1999-2015.

Journal of the Pediatric Infectious Diseases Society

Abu-Raya B and Bettinger JA and Vanderkooi OG and Vaudry W and Halperin SA and Sadarangani M and Members of the Canadian Immunization Monitoring Program and Active (IMPACT)

DOI: 10.1093/jpids/piy128 PubMed: 30535079

04 / 2020

Clinical Correlates of Human Immunodeficiency Virus-1 (HIV-1) DNA and Inducible HIV-1 RNA Reservoirs in Peripheral Blood in Children With Perinatally Acquired HIV-1 Infection With Sustained Virologic Suppression for at Least 5 Years.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Bitnun A and Ransy DG and Brophy J and Kakkar F and Hawkes M and Samson L and Annabi B and Pagliuzza A and Morand JA and Sauve L and Chomont N and Lavoie S and Kim J and Sandstrom P and Early Pediatric Initiation Canada Child Cure Cohort (EPIC4) Research Group

DOI: 10.1093/cid/ciz251 PubMed: 30919879

02 / 2020

Impact of school closures on learning, and child and family well-being

British Columbia Medical Journal

Dove, N. and Wong, J. and Smolina, K. and Doan, Q. and Sauve, L. and Corneil, T. and Gustafson, R.

Risk factors for cerebrospinal fluid shunt infections during an outbreak: a case-control study.

The Journal of hospital infection

McAlpine AK and Sauve LJ and Collet JC and Goldfarb DM and Guest E and McDonald PJ and Zheng A and Srigley JA

DOI: 10.1016/j.jhin.2019.12.012 PubMed: 31870886

12 / 2019

Congenital anomalies following antenatal exposure to dolutegravir: a Canadian surveillance study

BJOG: An International Journal of Obstetrics & Gynaecology

DOI: 10.1111/1471-0528.15838

07 / 2019

Preventing vertical transmission of HCV in Canada

Canadian Medical Association Journal

DOI: 10.1503/cmaj.181662

06 / 2019

152 Child development in HIV Exposed, Uninfected Children: Challenges with Accessing Services.

Paediatrics & Child Health

Yang L and Alimenti A and Lipson A and Lanphear N and Sauve L

05 / 2019

Neurodevelopmental outcomes and in utero antiretroviral exposure in HIV-exposed uninfected children

AIDS

DOI: 10.1097/qad.0000000000001985

08 / 2018

Missed opportunities for prevention of vertical HIV transmission in Canada, 1997-2016: a surveillance study.

CMAJ open

Bitnun A and Lee T and Brophy J and Samson LM and Kakkar F and Vaudry W and Tan B and Money DM and Singer J and Sauv LJ and Alimenti A and Canadian Perinatal HIV Surveillance Program

DOI: 10.9778/cmajo.20180016 PubMed: 29759976

05 / 2018

The Oak Tree Clinic: The Envisioned Model of Care for Women Living with Human Immunodeficiency Virus in Canada

Women's Health Issues

Mary Kestler and Melanie Murray and Deborah Money and Laura Sauve and Neora Pick

DOI: 10.1016/j.whi.2017.11.007

03 / 2018

Ten-year-old traveller with fever and an exceptional exanthem.

Journal of paediatrics and child health

Osowicki J and Badawi M and Al-Rawahi GN and Rehmus WE and Sauv L

DOI: 10.1111/jpc.1_13703 PubMed: 29314380

01 / 2018

Enteric fever in a multicultural Canadian tertiary care pediatric setting: A 28-year review

Journal of the Pediatric Infectious Diseases Society

Zhou, K. and Sauve, L.J. and Richardson, S.E. and Lee Ford-Jones, E. and Morris, S.K.

DOI: 10.1093/jpids/piw007

Hospitalization for Influenza A Versus B.

Pediatrics

DOI: 10.1542/peds.2015-4643 PubMed: 27535144

08 / 2016

Enteric Fever in a Multicultural Canadian Tertiary Care Pediatric Setting: A 28-Year Review.

Journal of the Pediatric Infectious Diseases Society

PubMed: 26952095

03 / 2016

Respiratory Presentation of Pediatric Patients in the 2014 Enterovirus D68 Outbreak.

Canadian Respiratory Journal : Journal of the Canadian Thoracic Society

Martin G and Li R and Cook VE and Carwana M and Tilley P and Sauve L and Tang P and Kapur A and Yang CL

DOI: 10.1155/2016/8302179 PubMed: 27610028

8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015).

Journal of the International AIDS Society

DOI: 10.7448/ias.18.5.20479 PubMed: 26205488

07 / 2015

Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study.

Clinical Infectious Diseases

PubMed: 25605282

04 / 2015

Development and validation of weight, height and age bands to guide the prescription of fixed-dose dispersible tablet formulations

Journal of Pediatric Pharmacology and Therapeutics

Larson, C.P. and Sauv, L. and Senkungu, J.K. and El Arifeen, S. and Brant, R.

DOI: 10.5863/1551-6776-20.1.24

Development and validation of weight, height and age bands to guide the prescription of fixed-dose dispersible tablet formulations.

Journal of Pediatric Pharmacology and Therapeutics

PubMed: 25859167

Canadian Paediatric Society 92nd Annual Conference: Abstracts.

Paediatrics & Child Health

24(th) Annual Canadian Conference on HIV/AIDS Research/24(e) Congres Annuel Canadien de Recherche sur le VIH/sida CAHR Committees / Comites de l'ACRV.

The Canadian Journal of Infectious Diseases & Medical Microbiology

PubMed: 26015799

1614High Rates of Preterm Birth and Small for Gestational Age in a Cohort of HIV Infected Women in Canada: Role of Ritonavir Boosted Regimens?

Open forum infectious diseases

Kakkar F and Boucoiran I and Lee T and Singer J and Sauve LJ and Samson LM and Money D

12 / 2014

The impact of the meningococcal serogroup C conjugate vaccine in Canada between 2002 and 2012.

Clinical Infectious Diseases

PubMed: 25069868

11 / 2014

Prevention of vertical HIV transmission and management of the HIV-exposed infant in Canada in 2014.

The Canadian Journal of Infectious Diseases & Medical Microbiology

Bitnun A and Brophy J and Samson L and Alimenti A and Kakkar F and Lamarre V and Moore D and Karatzios C and Seigel S and Sauve L and Vaudry W and Yudin MH and Money D

DOI: 10.1155/2014/526019 PubMed: 24855474

03 / 2014

Burden of seasonal influenza in children with neurodevelopmental conditions

Pediatric Infectious Disease Journal

Burton, C. and Vaudry, W. and Moore, D. and Bettinger, J.A. and Tran, D. and Halperin, S.A. and Scheifele, D.W. and Morris, R. and Dry, P. and Lebel, M. and Le Saux, N. and Ford-Jones, L. and Embree, J. and Law, B. and Tan, B. and Jadavji, T. and Vaudry, W. and Sauv, L.

DOI: 10.1097/INF.0000000000000272

Prevention of vertical HIV transmission and management of the HIV-exposed infant in Canada in 2014

Canadian Journal of Infectious Diseases and Medical Microbiology

Bitnun, A. and Brophy, J. and Samson, L. and Alimenti, A. and Kakkar, F. and Lamarre, V. and Moore, D. and Karatzios, C. and Seigel, S. and Sauve, L. and Vaudry, W. and Yudin, M. and Money, D.

Diversity of Canadian meningococcal serogroup B isolates and estimated coverage by an investigational meningococcal serogroup B vaccine (4CMenB).

Vaccine

PubMed: 23588089

12 / 2013

Unusual patterns of IgG avidity in some young children following two doses of the adjuvanted pandemic H1N1 (2009) influenza virus vaccine.

Clinical and Vaccine Immunology

PubMed: 23345582

04 / 2013

Applicability of the Brighton Collaboration Case Definition for seizure after immunization in active and passive surveillance in Canada

Vaccine

Top, K.A. and Constantinescu, C.M. and Laflche, J. and Bettinger, J.A. and Scheifele, D.W. and Vaudry, W. and Halperin, S.A. and Law, B.J. and Morris, R. and Bridger, N. and Halperin, S. and Top, K. and Dry, P. and Mills, E. and Moore, D. and Lebel, M. and MacDonald, N. and Le Saux, N. and Wang, E. and Ford-Jones, L. and Tran, D. and Law, B. and Embree, J. and Tan, B. and McConnell, A. and Jadavji, T. and Vanderkooi, O. and Vaudry, W. and Scheifele, D. and Sauv, L.

DOI: 10.1016/j.vaccine.2013.09.048

Development and evaluation of global child health educational modules

Pediatrics

Audcent, T.A. and MacDonnell, H.M. and Moreau, K.A. and Hawkes, M. and Sauve, L.J. and Crockett, M. and Fisher, J.A. and Goldfarb, D.M. and Hunter, A.J. and McCarthy, A.E. and Pernica, J.M. and Liu, J. and Luong, T.-N. and Sandhu, A.K. and Rashed, S. and Levy, A. and Brenner, J.L.

DOI: 10.1542/peds.2013-1534

Comparison of children hospitalized with seasonal versus pandemic influenza A, 2004-2009.

Tran D and Vaudry W and Moore DL and Bettinger JA and Halperin SA and Scheifele DW and Aziz S and IMPACT investigators

PubMed: 22931901

09 / 2012

The effect of funded varicella immunization programs on varicella-related hospitalizations in IMPACT centers, Canada, 2000-2008.

The Pediatric Infectious Disease Journal

PubMed: 22647896

09 / 2012

Molecular characterization of rotavirus isolates from select Canadian pediatric hospitals

BMC Infectious Diseases

McDermid, A. and Le Saux, N. and Grudeski, E. and Bettinger, J.A. and Manguiat, K. and Halperin, S.A. and MacDonald, L. and Dry, P. and Embree, J. and Vaudry, W. and Booth, T.F. and Morris, R. and Halperin, S. and Dry, P. and Moore, D. and Lebel, M. and Le Saux, N. and Tran, D. and Embree, J. and Tan, B. and Jadavji, T. and Vaudry, W. and Sauv, L.

DOI: 10.1186/1471-2334-12-306

The responses of Aboriginal Canadians to adjuvanted pandemic (H1N1) 2009 influenza vaccine.

Canadian Medical Association Journal

PubMed: 21788422

09 / 2011

Drug-resistant Tuberculosis

The Pediatric Infectious Disease Journal

Mona Al-Dabbagh and Keswadee Lapphra and Rumi McGloin and Kelsey Inrig and H. Simon Schaaf and Ben J. Marais and Laura Sauve and Ian Kitai and Tobias R. Kollmann

DOI: 10.1097/inf.0b013e31820b583d

06 / 2011

Evaluation of adjuvanted pandemic H1N1(2009) influenza vaccine after one and two doses in young children.

The Pediatric Infectious Disease Journal

PubMed: 21178654

05 / 2011

The responses of Aboriginal Canadians to adjuvanted pandemic (H1N1) 2009 influenza vaccine

CMAJ

Rubinstein, E. and Predy, G. and Sauv, L. and Hammond, G.W. and Aoki, F. and Sikora, C. and Li, Y. and Law, B. and Halperin, S. and Scheifele, D.

DOI: 10.1503/cmaj.110196

Pandemic influenza in Canadian children: a summary of hospitalized pediatric cases.

Vaccine

PubMed: 20189488

04 / 2010

Postvaccination Thrombocytopenia in Canada

The Pediatric Infectious Disease Journal

Laura J. Sauv and Julie Bettinger and David Scheifele and Scott Halperin and Wendy Vaudry and Barbara Law

DOI: 10.1097/inf.0b013e3181d2bb45

02 / 2010

The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000-2007.

Vaccine

PubMed: 20044050

02 / 2010

Pandemic influenza in Canadian children: A summary of hospitalized pediatric cases

Vaccine

Bettinger, J.A. and Sauv, L.J. and Scheifele, D.W. and Moore, D. and Vaudry, W. and Tran, D. and Halperin, S.A. and Pelletier, L.

DOI: 10.1016/j.vaccine.2010.02.044

Increasing fluoroquinolone resistance in Salmonella typhi in Ontario, 2002-2007.

Morris SK and Richardson SE and Sauve LJ and Ford-Jones EL and Jamieson F

PubMed: 19478267

06 / 2009

Do childhood vaccines cause thrombocytopenia?

Paediatrics & Child Health

Laura J Sauv and David Scheifele

DOI: 10.1093/pch/14.1.31

01 / 2009

Short report: Increasing fluoroquinolone resistance in Salmonella typhi in Ontario, 2002-2007

American Journal of Tropical Medicine and Hygiene

Morris, S.K. and Richardson, S.E. and Sauve, L.J. and Ford-Jones, E.L. and Jamieson, F.

Case 2: Fever in a new immigrant

Paediatrics and Child Health

Brophy, J. and Sauve, L.

Harmonization of regional health data requirements in the South Pacific.

Clinical Performance and Quality Healthcare

PubMed: 10167221

The Health Interview: Automated Assessment in a Multidisciplinary Outpatient Hypertension Treatment Program

M.D. Computing

Taenzer, P.A. and Sauve, L. and Burgess, E.D. and Milkavich, L. and Whitmore, B.

Canadian Perinatal HIV Surveillance Program (WHRI)

Dr. Sauvé recently took over as co-chair of the CPHSP, which as done active surveillance for vertical transmission of HIV in 22 sites across Canada since 1990. It is funded by the Public Health Agency of Canada. This surveillance program prospectively collects data on all births to HIV infected women in the 22 participating sites, as well as all vertically HIV infected children in Canada. It provides important epidemiologic data on vertical transmission of HIV in Canada. Data is presented annually at HIV meetings and in 2012, there was a major article in AIDS (completed prior to when Dr Sauvé joined the team).

Flocked swab evaluation

In this study which is in the final manuscript stages, Dr Sauvé and her co-investigators prospectively evaluated two methods of acquiring samples for respiratory virus testing, comparing the BC Children's Hospital standard of nasopharyngeal wash, to a newer technology: flocked nasopharyngeal swabs.

Immunization Monitoring Program, Active

Dr. Sauvé is the BC site investigator for this project which has ongoing surveillance for vaccine preventable diseases and adverse events following immunization; there are 12 sites across the country. She sits on the AEFI and Haemophilous Influenzae working groups. Nurse monitors at each site do active surveillance for the target conditions, finding all hospitalized cases of those target conditions using a variety of methods. Data is entered into the IMPACT databases which are coordinated through the Vaccine Evaluation Center's IMPACT data center (led by CFRI investigators Dr. David Scheifele and Dr. Julie Bettinger). Summarized surveillance data is provided to the Public Health Agency of Canada and published in peer-reviewed publications.

Grants

BC Children's Hospital Foundation Telethon Fund (flocked swab study) $24,000

CPHSP - $39,000 per year (ongoing)

IMPACT / CPS - Approximately $57,000 per year for BC Site (ongoing)

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