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Anna Lee

(she/her)
MDCM, PhD

Investigator and Pediatric Pathologist, BC Children's Hospital

One of my research interests is studying molecular alterations in developing organs in fetal and infant disorders. I am currently studying congenital diaphragmatic hernia (CDH), in which a hole forms in the fetal diaphragm which can lead to altered fetal lung growth and development and post-natal complications. Fetal lung development in CDH is altered by molecular mechanisms and environmental factors that are currently not well understood. I am collaborating with Dr. Prusinkiewicz and Dr. Mudri (Victoria) to use immunohistochemistry and qPCR techniques on CDH archival specimens to characterize lung proteins and mRNAs of interest.

My research interests also extend to women’s health, specifically endometriosis, which is associated with pain (often severe), decreased fertility, and in rare instances, cancers. I am working with WHRI investigators Dr. P. Yong (WHRI) and Dr. M. Anglesio to characterize expression of select proteins in endometriosis biopsy samples, correlate it with clinical variables, and find patterns that inform better prognostication or treatments. Our work has been published in a number of reproductive science, pathology, and general scientific interest journals.

I also have a long-standing collaboration with various members in the Department of Pediatric Radiology at BC Children's Hospital, performing radiology-pathology correlation in a wide variety of disorders in fetuses, infants, and children. This work has led to multiple peer-reviewed studies, educational exhibits, and conference presentations.

Finally, I am a pathology reviewer for the Peds POG and PROFYLE initiatives.

Academic Affiliations

  • Clinical Associate Professor, , Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia
  • Research Theme: Healthy Starts

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

(604) 875-3422

anna.lee@cw.bc.ca

Early-Onset Macrosomia, Advanced Brain Maturation, and Gonadoblastoid Testicular Dysplasia in a Fetus With a PTEN Variant

Prenatal Diagnosis

Lynch, D.C. and Lee, A.F. and Castle, A.M.R.

DOI: 10.1002/pd.6765

Somatic PTEN and ARID1A loss and endometriosis disease burden: a longitudinal study

Human Reproduction

Tucker, D.R. and Lee, A.F. and Orr, N.L. and Alotaibi, F.T. and Noga, H.L. and Williams, C. and Allaire, C. and Bedaiwy, M.A. and Huntsman, D.G. and K{\"o}bel, M. and Anglesio, M.S. and Yong, P.J.

DOI: 10.1093/humrep/deae269

A multimorphic variant in ThPOK causes an inborn error of immunity with T cell defects and fibrosis

Journal of Experimental Medicine

Vaseghi-Shanjani, M. and Sharma, M. and Yousefi, P. and Samra, S. and Laverty, K.U. and Jolma, A. and Razavi, R. and Yang, A.H.W. and Albu, M. and Golding, L. and Lee, A.F. and Tan, R. and Richmond, P.A. and Bosticardo, M. and Rayment, J.H. and Yang, C.L. and Hildebrand, K.J. and Brager, R. and Demos, M.K. and Lau, Y.-L. and Notarangelo, L.D. and Hughes, T.R. and Biggs, C.M. and Turvey, S.E.

DOI: 10.1084/jem.20241174

ASXL1 deficiency causes epigenetic dysfunction, combined immunodeficiency, and EBV-associated lymphoma

Journal of Experimental Medicine

Fu, M.P. and Sharma, M. and Yousefi, P. and Merrill, S.M. and Tan, R. and Samra, S. and Setiadi, A. and Golding, L. and Modi, B.P. and Del Bel, K.L. and Deyell, R.J. and Rozmus, J. and Rehmus, W. and Hildebrand, K.J. and James, E. and Blanchard-Rohner, G. and Lin, S. and Shopsowitz, K.E. and Terry, J. and Lee, A.F. and Dr{\"o}gem{\"o}ller, B.I. and Matthews, A. and Tarailo-Graovac, M. and Sauv{\'e}, L. and Mitchell, H. and Prendiville, J.S. and MacIsaac, J.L. and Dever, K. and Lin, D.T.S. and Meijer, M. and Ross, C.J.D. and Dobson, S.R.M. and Vercauteren, S.M. and Wasserman, W.W. and van Karnebeek, C.D.M. and McKinnon, M.L. and Kobor, M.S. and Turvey, S.E. and Biggs, C.M.

DOI: 10.1084/jem.20240945

Nerve Bundle Density and Expression of NGF and IL-1 Are Intra-Individually Heterogenous in Subtypes of Endometriosis

Biomolecules

Mahfuza Sreya and Dwayne Tucker and Jennifer Yi and Fahad T. Alotaibi and Anna F. Lee and Heather Noga and Paul J. Yong

DOI: 10.3390/biom14050583

05 / 2024

A multimorphic variant in ThPOK causes a novel human disease characterized by T cell abnormalities, immunodysregulation, allergy, and fibrosis

Medrxiv

Vaseghi-Shanjani, M. and Sharma, M. and Yousefi, P. and Samra, S. and Laverty, K.U. and Jolma, A. and Razavi, R. and Yang, A.H.W. and Albu, M. and Golding, L. and Lee, A.F. and Tan, R. and Richmond, P.A. and Bosticardo, M. and Rayment, J.H. and Yang, C.L. and Hildebrand, K.J. and Brager, R. and Demos, M.K. and Lau, Y.L. and Notarangelo, L.D. and Hughes, T.R. and Biggs, C.M. and Turvey, S.E.

DOI: 10.1101/2024.06.26.24309360

Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency

Pediatric Allergy and Immunology

Duke, S. and Maiarana, J. and Yousefi, P. and Burks, E. and Gerrie, S. and Setiadi, A. and Amid, A. and Boerkel, C. and Erdle, S. and Guttman, O. and Kanani, A. and Lawrence, S. and Lee, A.F. and Pourshahnazari, P. and Rayar, M. and Rozmus, J. and Schrader, D. and Sharma, M. and Shopsowitz, K.E. and Tan, R. and To, F. and Yang, C. and Hildebrand, K.J. and James, E. and Turvey, S.E. and Markle, J.G. and Biggs, C.M.

DOI: 10.1111/pai.14077

Whole genome and transcriptome integrated analyses guide clinical care of pediatric poor prognosis cancers

Nature Communications

Deyell, R.J. and Shen, Y. and Titmuss, E. and Dixon, K. and Williamson, L.M. and Pleasance, E. and Nelson, J.M.T. and Abbasi, S. and Krzywinski, M. and Armstrong, L. and Bonakdar, M. and Ch?ng, C. and Chuah, E. and Dunham, C. and Fok, A. and Jones, M. and Lee, A.F. and Ma, Y. and Moore, R.A. and Mungall, A.J. and Mungall, K.L. and Rogers, P.C. and Schrader, K.A. and Virani, A. and Wee, K. and Young, S.S. and Zhao, Y. and Jones, S.J.M. and Laskin, J. and Marra, M.A. and Rassekh, S.R.

DOI: 10.1038/s41467-024-48363-5

Placenta and Pregnancy-Related Diseases

Erica Schollenberg and Anna F. Lee and Jefferson Terry

DOI: 10.1007/978-981-19-7696-4_15-1

Decreased -catenin Protein in Lungs From Human Congenital Diaphragmatic Hernia Archival Pathology Specimens: A Case-control Study

Journal of Pediatric Surgery

Prusinkiewicz, M.A. and Park, C. and Cheung, C. and Li, Y.J. and Poon, B. and Skarsgard, E.D. and Lavoie, P.M. and Lee, A.F. and Mudri, M.

DOI: 10.1016/j.jpedsurg.2024.01.034

Autopsy-Based Growth Charts May under-Detect Fetal Growth Restriction at Autopsy

Fetal and Pediatric Pathology

Kim, M.J. and Hutcheon, J.A. and Lee, A.F. and Liauw, J.

DOI: 10.1080/15513815.2023.2299491

A Pediatric Case of Reninoma Presenting with Paraneoplastic Syndrome of Inappropriate Antidiuretic Hormone Secretion

Hormone Research in Paediatrics

Sekhon, S.S. and Taha, K. and Kim, L.H. and Humphreys, R. and Patel, T.J. and Andrews, A.R. and Lee, A.F. and Abdulhussein, F.S.

DOI: 10.1159/000533521

KRAS mutations and endometriosis burden of disease

Journal of Pathology: Clinical Research

Orr, N.L. and Albert, A. and Liu, Y.D. and Lum, A. and Hong, J. and Ionescu, C.L. and Senz, J. and Nazeran, T.M. and Lee, A.F. and Noga, H. and Lawrenson, K. and Allaire, C. and Williams, C. and Bedaiwy, M.A. and Anglesio, M.S. and Yong, P.J.

DOI: 10.1002/cjp2.317

Pathologic Skull Fracture in a Near-Term Neonate with Arthrochalasia Type Ehlers-Danlos Syndrome: A Case Report

Fetal and Pediatric Pathology

Yi Ariel Liu and Chieko Chijiwa and Christopher P. Dunham and Douglas H. Jamieson and Alfonso Solimano and Julianne van Schalkwyk and Millan S. Patel and Anna F. Lee

DOI: 10.1080/15513815.2020.1753269

01 / 2022

Piriform fossa sinus tract " a 15-year retrospective review with a focus on atypical neonatal presentations

Pediatric Radiology

Tshuma, M. and Chadha, N.K. and Lee, A.F. and Bray, H.

DOI: 10.1007/s00247-021-05245-y

The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies

Journal of Pathology: Clinical Research

Tessier-Cloutier, B. and Grewal, J.K. and Jones, M.R. and Pleasance, E. and Shen, Y. and Cai, E. and Dunham, C. and Hoang, L. and Horst, B. and Huntsman, D.G. and Ionescu, D. and Karnezis, A.N. and Lee, A.F. and Lee, C.H. and Lee, T.H. and Twa, D.D.W. and Mungall, A.J. and Mungall, K. and Naso, J.R. and Ng, T. and Schaeffer, D.F. and Sheffield, B.S. and Skinnider, B. and Smith, T. and Williamson, L. and Zhong, E. and Regier, D.A. and Laskin, J. and Marra, M.A. and Gilks, C.B. and Jones, S.J.M. and Yip, S.

DOI: 10.1002/cjp2.265

Human germline biallelic complete NFAT1 deficiency causes the triad of progressive joint contractures, osteochondromas, and susceptibility to B cell malignancy

Medrxiv

Sharma, M. and Fu, M.P. and Lu, H.Y. and Sharma, A.A. and Modi, B.P. and Michalski, C. and Lin, S. and Dalmann, J. and Salman, A. and Del Bel, K.L. and Waqas, M. and Terry, J. and Setiadi, A. and Lavoie, P.M. and Wasserman, W.W. and Mwenifumbo, J. and Kobor, M.S. and Lee, A.F. and Lehman, A. and Cheng, S. and Cooper, A. and Patel, M.S. and Turvey, S.E.

DOI: 10.1101/2022.01.30.22269378

Human complete NFAT1 deficiency causes a triad of joint contractures, osteochondromas, and B-cell malignancy

Blood

Sharma, M. and Fu, M.P. and Lu, H.Y. and Sharma, A.A. and Modi, B.P. and Michalski, C. and Lin, S. and Dalmann, J. and Salman, A. and Del Bel, K.L. and Waqas, M. and Terry, J. and Setiadi, A. and Lavoie, P.M. and Wasserman, W.W. and Mwenifumbo, J. and Kobor, M.S. and Lee, A.F. and Kuchenbauer, F. and Lehman, A. and Cheng, S. and Cooper, A. and Patel, M.S. and Turvey, S.E.

DOI: 10.1182/blood.2022015674

Spectrum of bowel wall thickening on ultrasound with pathological correlation in children

Pediatric Radiology

Limantoro, I. and Lee, A.F. and Rosenbaum, D.G.

DOI: 10.1007/s00247-022-05376-w

Malignant Mesothelioma With EWSR1-ATF1 Fusion in Two Adolescent Male Patients

Pediatric and Developmental Pathology

Hezhen Ren and S Rod Rassekh and Atilano Lacson and Cheng-Han Lee and Brendan C Dickson and Catherine T Chung and Anna F Lee

DOI: 10.1177/10935266211021222

11 / 2021

Granulocyte Colony Stimulating Factor Expression in Breast Cancer and Its Association with Carbonic Anhydrase IX and Immune Checkpoints

Cancers

Shawn C. Chafe and Nazia Riaz and Samantha Burugu and Dongxia Gao and Samuel C. Y. Leung and Anna F. Lee and Cheng-Han Lee and Shoukat Dedhar and Torsten O. Nielsen

DOI: 10.3390/cancers13051022

03 / 2021

The paediatric thymus: recognising normal and ectopic thymic tissue.

Clinical radiology

DOI: 10.1016/j.crad.2021.02.017 PubMed: 33762135

03 / 2021

Diffuse alveolar haemorrhage in a child with trisomy 21.

Journal of paediatrics and child health

DOI: 10.1111/jpc.15331 PubMed: 33694213

03 / 2021

Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury

npj Precision Oncology

Williamson, L.M. and Rive, C.M. and Di Francesco, D. and Titmuss, E. and Chun, H.-J.E. and Brown, S.D. and Milne, K. and Pleasance, E. and Lee, A.F. and Yip, S. and Rosenbaum, D.G. and Hasselblatt, M. and Johann, P.D. and Kool, M. and Harvey, M. and Dix, D. and Renouf, D.J. and Holt, R.A. and Nelson, B.H. and Hirst, M. and Jones, S.J.M. and Laskin, J. and Rassekh, S.R. and Deyell, R.J. and Marra, M.A.

DOI: 10.1038/s41698-021-00238-4

Heterotopic gastric mucosa in the rectum

Journal of Pediatric Surgery Case Reports

Fernandes S., Safavi A., Tessier-Cloutier B., Lee A., Baird R.

DOI: 10.1016/j.epsc.2020.101673

12 / 2020

Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas

OncoImmunology

DOI: 10.1080/2162402x.2020.1747340

01 / 2020

Fontan-Associated Liver Disease: Spectrum of Disease in Children and Adolescents.

Journal of the American Heart Association

DOI: 10.1161/jaha.119.012529 PubMed: 31902322

01 / 2020

Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis

PLOS ONE

DOI: 10.1371/journal.pone.0219064

07 / 2019

ALK-Positive Lung Adenocarcinoma Arising in an Adolescent Treated for Relapsed Neuroblastoma

Journal of Thoracic Oncology

Yazeed Alwelaie and Rebecca J. Deyell and Helen R. Nadel and Tracy Tucker and Janessa Laskin and S. Rod Rassekh and Chen Zhou and John C. English and Anna F. Lee

DOI: 10.1016/j.jtho.2019.02.010

06 / 2019

Complex Compound Inheritance of Lethal Lung Developmental Disorders Due to Disruption of the TBX-FGF Pathway.

American journal of human genetics

Karolak JA and Vincent M and Deutsch G and Gambin T and Cogn B and Pichon O and Vetrini F and Mefford HC and Dines JN and Golden-Grant K and Dipple K and Freed AS and Leppig KA and Stankiewicz P

DOI: 10.1016/j.ajhg.2018.12.010 PubMed: 30639323

01 / 2019

Iatrogenic endometriosis harbors somatic cancer-driver mutations.

Human reproduction (Oxford, England)

Lac V and Verhoef L and Aguirre-Hernandez R and Nazeran TM and Tessier-Cloutier B and Praetorius T and Orr NL and Noga H and Lum A and Khattra J and Prentice LM and Co D and Kbel M and Anglesio MS

DOI: 10.1093/humrep/dey332 PubMed: 30428062

01 / 2019

Application of genomics to identify therapeutic targets in recurrent pediatric papillary thyroid carcinoma.

Cold Spring Harbor molecular case studies

Ronsley R and Rassekh SR and Shen Y and Lee AF and Jantzen C and Halparin J and Albert C and Hawkins DS and Amed S and Rothstein R and Mungall AJ and Dix D and Blair G and Nadel H and J Deyell R

DOI: 10.1101/mcs.a002568 PubMed: 29610391

04 / 2018

Comparative RNA-Sequencing Analysis Benefits a Pediatric Patient With Relapsed Cancer

JCO Precision Oncology

Yulia Newton and S. Rod Rassekh and Rebecca J. Deyell and Yaoqing Shen and Martin R. Jones and Chris Dunham and Stephen Yip and Sreeja Leelakumari and Jingchun Zhu and Duncan McColl and Teresa Swatloski and Sofie R. Salama and Tony Ng and Glenda Hendson and Anna F. Lee and Yussanne Ma and Richard Moore and Andrew J. Mungall and David Haussler and Joshua M. Stuart and Colleen Jantzen and Janessa Laskin and Steven J.M. Jones and Marco A. Marra and Olena Morozova

DOI: 10.1200/po.17.00198

04 / 2018

Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency

LymphoSign Journal

Victoria E. Cook, Connie L. Yang, Anna F. Lee, Alexia Dabadie, Joanne Luider, Kyla J. Hildebrand, Anne Junker, Stuart E. Turvey

DOI: 10.14785/lymphosign-2017-0003

06 / 2017

Nivolumab in the Treatment of Refractory Pediatric Hodgkin Lymphoma

Journal of Pediatric Hematology/Oncology

Foran, A.E. and Nadel, H.R. and Lee, A.F. and Savage, K.J. and Deyell, R.J.

DOI: 10.1097/MPH.0000000000000703

Nivolumab in the Treatment of Refractory Pediatric Hodgkin Lymphoma.

Foran AE and Nadel HR and Lee AF and Savage KJ and Deyell RJ

PubMed: 27841828

11 / 2016

Phenotypic expansion of TBX4 mutations to include acinar dysplasia of the lungs.

Szafranski P and Coban-Akdemir ZH and Rupps R and Grazioli S and Wensley D and Jhangiani SN and Popek E and Lee AF and Lupski JR and Boerkoel CF and Stankiewicz P

DOI: 10.1002/ajmg.a.37822 PubMed: 27374786

09 / 2016

Nerve Bundles and Deep Dyspareunia in Endometriosis.

Williams C and Hoang L and Yosef A and Alotaibi F and Allaire C and Brotto L and Fraser IS and Bedaiwy MA and Ng TL and Lee AF and Yong PJ

DOI: 10.1177/1933719115623644 PubMed: 26711313

07 / 2016

Paternal uniparental disomy 11p15.5 in the pancreatic nodule of an infant with Costello syndrome: Shared mechanism for hyperinsulinemic hypoglycemia in neonates with Costello and Beckwith-Wiedemann syndrome and somatic loss of heterozygosity in Costello syndrome driving clonal expansion.

Gripp KW and Robbins KM and Sheffield BS and Lee AF and Patel MS and Yip S and Doyle D and Stabley D and Sol-Church K

DOI: 10.1002/ajmg.a.37471 PubMed: 26572961

03 / 2016

BAP1 immunohistochemistry and p16 FISH to separate benign from malignant mesothelial proliferations.

Sheffield BS and Hwang HC and Lee AF and Thompson K and Rodriguez S and Tse CH and Gown AM and Churg A

DOI: 10.1097/pas.0000000000000394 PubMed: 25634745

07 / 2015

Fatal congenital hypertrophic cardiomyopathy and a pancreatic nodule morphologically identical to focal lesion of congenital hyperinsulinism in an infant with costello syndrome: case report and review of the literature.

Sheffield BS and Yip S and Ruchelli ED and Dunham CP and Sherwin E and Brooks PA and Sur A and Singh A and Human DG and Patel MS and Lee AF

DOI: 10.2350/14-07-1525-cr.1 PubMed: 25668678

Postmortem genetic diagnosis of long QT syndrome in a case of sudden unexplained death of a young child: A case report and overview of regional guidelines for genetic testing

BC Medical Journal

Anna F. Lee, MDCM, PhD, FRCPC, Andrew D. Krahn, MD, Shubhayan Sanatani, MD, FRCPC, Deborah E. McFadden, MD, FRCPC. Postmortem genetic diagnosis of long QT syndrome in a case of sudden unexplained death of a young child: A case report and overview of regional guidelines for genetic testing. BCMJ, Vol. 56, No. 10, December, 2014, page(s) 486-491 " Articles.

12 / 2014

Significant immunohistochemical expression of human chorionic gonadotropin in high-grade osteosarcoma is rare, but may be associated with clinically elevated serum levels.

Lee AF and Pawel BR and Sullivan LM

DOI: 10.2350/14-02-1436-oa.1 PubMed: 24856811

IMP3 and GLUT-1 immunohistochemistry for distinguishing benign from malignant mesothelial proliferations.

Lee AF and Gown AM and Churg A

DOI: 10.1097/pas.0b013e31826ab1c0 PubMed: 23108021

03 / 2013

Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer

Pharmacogenomics Journal

Griffith, M. and Mwenifumbo, J.C. and Cheung, P.Y. and Paul, J.E. and Pugh, T.J. and Tang, M.J. and Chittaranjan, S. and Morin, R.D. and Asano, J.K. and Ally, A.A. and Miao, L. and Lee, A. and Chan, S.Y. and Taylor, G. and Severson, T. and Hou, Y.-C. and Griffith, O.L. and Cheng, G.S.W. and Novik, K. and Moore, R. and Luk, M. and Owen, D. and Brown, C.J. and Morin, G.B. and Gill, S. and Tai, I.T. and Marra, M.A.

DOI: 10.1038/tpj.2011.65

Measuring dopaminergic function in the 6-OHDA-lesioned rat: A comparison of PET and microdialysis

Ejnmmi Research

Walker, M.D. and Dinelle, K. and Kornelsen, R. and Lee, A. and Farrer, M.J. and Stoessl, A.J. and Sossi, V.

DOI: 10.1186/2191-219X-3-69

Measurements of Dopaminergic Function in the Rat Brain Using [18F]FDOPA PET and Microdialysis

Catecholamine Research in the 21st Century Abstracts and Graphical Abstracts 10th International Catecholamine Symposium 2012

Walker, M.D. and Dinelle, K. and Kornelsen, R. and McCormick, S. and Mah, C. and Lee, A. and Holden, J.E. and Farrer, M.J. and Stoessl, A.J. and Sossi, V.

DOI: 10.1016/B978-0-12-800044-1.00144-6

Recurrent congestive heart failure in a child due to probable myocarditis.

Lee AF and Chiasson DA and Smythe JF and Sanatani S

DOI: 10.1007/s00246-011-0109-3 PubMed: 21910020

01 / 2012

Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.

Heravi-Moussavi A and Anglesio MS and Cheng SW and Senz J and Yang W and Prentice L and Fejes AP and Chow C and Tone A and Kalloger SE and Hamel N and Roth A and Ha G and Wan AN and Maines-Bandiera S and Salamanca C and Pasini B and Clarke BA and Lee AF and Lee CH

DOI: 10.1056/nejmoa1102903 PubMed: 22187960

01 / 2012

Low-grade fibromyxoid sarcoma of the perineum with heterotopic ossification: case report and review of the literature.

Lee AF and Yip S and Smith AC and Hayes MM and Nielsen TO and O'Connell JX

DOI: 10.1016/j.humpath.2011.02.022 PubMed: 21658743

11 / 2011

Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas.

Wiegand KC and Lee AF and Al-Agha OM and Chow C and Kalloger SE and Scott DW and Steidl C and Wiseman SM and Gascoyne RD and Gilks B and Huntsman DG

DOI: 10.1002/path.2911 PubMed: 21590771

07 / 2011

FLI-1 distinguishes Ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma.

Lee AF and Hayes MM and Lebrun D and Espinosa I and Nielsen GP and Rosenberg AE and Lee CH

DOI: 10.1097/pai.0b013e3181fd6697 PubMed: 21084965

05 / 2011

Periodic acid-schiff is superior to hematoxylin and eosin for screening prophylactic gastrectomies from CDH1 mutation carriers.

Lee AF and Rees H and Owen DA and Huntsman DG

DOI: 10.1097/pas.0b013e3181e28985 PubMed: 20534996

07 / 2010

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms.

Lee AF and Ho DK and Zanassi P and Walsh GS and Kaplan DR and Miller FD

DOI: 10.1523/jneurosci.1588-04.2004 PubMed: 15483136

10 / 2004

SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase.

Marsh HN and Dubreuil CI and Quevedo C and Lee A and Majdan M and Walsh GS and Hausdorff S and Said FA and Zoueva O and Kozlowski M and Siminovitch K and Neel BG and Miller FD and Kaplan DR

DOI: 10.1083/jcb.200309036 PubMed: 14662744

12 / 2003

p73 is required for survival and maintenance of CNS neurons.

Pozniak CD and Barnab-Heider F and Rymar VV and Lee AF and Sadikot AF and Miller FD

PubMed: 12427836

11 / 2002

p73 is required for survival and maintenance of CNS neurons

Journal of Neuroscience

Pozniak, C.D. and Barnab-Heider, F. and Rymar, V.V. and Lee, A.F. and Sadikot, A.F. and Miller, F.D.

DOI: 10.1523/jneurosci.22-22-09800.2002

Radiology-Pathology Correlation of Pediatric Conditions

I enjoy collaborating with my BC Children's Radiologist colleagues to correlate gross and microscopic features of pediatric surgical and biopsy specimens with their imaging findings. Conditions we have looked at in the past include pediatric renal tumors, pediatric bowel inflammatory conditions, pediatric interstitial lung disease, and thymic developmental abnormalities and differences. Our work has led to several educational exhibits at the RSNA and SPR annual meetings, and we have several manuscripts in preparation.

Pediatric Personalized Oncogenomics (PedsPOG)

I am a pathology reviewer for Pediatric Personalized Oncogenomics (PedsPOG), an innovative collaborative project that uses next-generation sequencing technologies to identify molecular pathways in pediatric cancers that could be targeted by pharmaceuticals (Site leaders: Drs. R. Deyell, R. Rassekh, BC Children's Oncology; Principal investigators: Drs. M. Marra, J. Laskin, BCCA Oncology). I am also involved in a related initiative, the Canada-wide "Precision Oncology for Young People" (PROFYLE).

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