Seth Parker
PhD
Investigator, BC Children's Hospital
STAR Protocols
Danisha Johal and Keeley G. Hewton and Sadie J. Gale and Amritpal S. Johal and Seth J. Parker
DOI: 10.1016/j.xpro.2025.10392909 / 2025
Journal of Biological Chemistry
Jessica C. Koe and Yuxi C. Zhong and Kiana Pashaoskooie and Gregory J. Kaczorowski and Maria L. Garcia and Seth J. Parker
DOI: 10.1016/j.jbc.2025.11052509 / 2025
Molecular & Cellular Proteomics
Zhiyu Zhao and Arshdeep Khurana and Frank Antony and John W. Young and Keeley G. Hewton and Zora Brough and Tianshuang Zhong and Seth J. Parker and Franck Duong van Hoa
DOI: 10.1016/j.mcpro.2023.10058808 / 2023
Nature Communications
Cameron Martino and Livia S. Zaramela and Bei Gao and Mallory Embree and Janna Tarasova and Seth J. Parker and Yanhan Wang and Huikuan Chu and Peng Chen and Kuei-Chuan Lee and Daniela Domingos Galzerani and Jivani M. Gengatharan and Asama Lekbua and Maxwell Neal and Rob Knight and Hidekazu Tsukamoto and Christian M. Metallo and Bernd Schnabl and Karsten Zengler
DOI: 10.1038/s41467-022-31973-208 / 2022
Proceedings of the National Academy of Sciences
Madeleine M. LaRue and Seth Parker and Joseph Puccini and Michael Cammer and Alec C. Kimmelman and Dafna Bar-Sagi
DOI: 10.1073/pnas.211916811904 / 2022
Nature Communications
Seth J. Parker and Joel Encarnacin-Rosado and Kate E. R. Hollinshead and David M. Hollinshead and Leonard J. Ash and Juan A. K. Rossi and Elaine Y. Lin and Albert S. W. Sohn and Mark R. Philips and Drew R. Jones and Alec C. Kimmelman
DOI: 10.1038/s41467-021-25228-908 / 2021
Cancer discovery
DOI: 10.1158/2159-8290.cd-20-1690 PubMed: 3402100205 / 2021
Metabolites
DOI: 10.3390/metabo11020112 PubMed: 3366938202 / 2021
Proceedings of the National Academy of Sciences
Subhadip Mukhopadhyay and Douglas E. Biancur and Seth J. Parker and Keisuke Yamamoto and Robert S. Banh and Joao A. Paulo and Joseph D. Mancias and Alec C. Kimmelman
DOI: 10.1073/pnas.202147511802 / 2021
Cell reports
DOI: 10.1016/j.celrep.2020.108231 PubMed: 3302765810 / 2020
Cancer & metabolism
DOI: 10.1186/s40170-020-00227-4 PubMed: 3300540109 / 2020
Nature
DOI: 10.1038/s41586-020-2229-5 PubMed: 3237695104 / 2020
Cancer discovery
DOI: 10.1158/2159-8290.cd-19-0959 PubMed: 3234102104 / 2020
Methods in molecular biology (Clifton, N.J.)
DOI: 10.1007/978-1-0716-0159-4_4 PubMed: 3189337001 / 2020
Nature
DOI: 10.1038/s41586-019-1832-9 PubMed: 3182727912 / 2019
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
DOI: 10.1093/ndt/gfx349 PubMed: 2942081708 / 2018
Cancer research
DOI: 10.1158/0008-5472.can-17-0015 PubMed: 2865224706 / 2017
Metabolic engineering
DOI: 10.1016/j.ymben.2016.12.010 PubMed: 2803477112 / 2016
Nature medicine
DOI: 10.1038/nm.4181 PubMed: 2764363809 / 2016
Cell reports
DOI: 10.1016/j.celrep.2016.06.102 PubMed: 2747728507 / 2016
Nature
DOI: 10.1038/nature17393 PubMed: 2704994504 / 2016
Molecular cell
DOI: 10.1016/j.molcel.2016.01.006 PubMed: 2679976301 / 2016
Nature communications
DOI: 10.1038/ncomms9784 PubMed: 2652242611 / 2015
Pharmacology & therapeutics
DOI: 10.1016/j.pharmthera.2015.05.003 PubMed: 2595646505 / 2015
Molecular cell
DOI: 10.1016/j.molcel.2014.09.024 PubMed: 2545884310 / 2014
Molecular cell
DOI: 10.1016/j.molcel.2014.05.008 PubMed: 2488221005 / 2014
Cancer research
DOI: 10.1158/0008-5472.can-14-0772-t PubMed: 2475547304 / 2014
Nature
DOI: 10.1038/nature12138 PubMed: 2366596205 / 2013
PloS one
DOI: 10.1371/journal.pone.0029208 PubMed: 2227952801 / 2012
Journal of biomolecular screening
DOI: 10.1177/1087057111433843 PubMed: 2227491201 / 2012
There are ~450 solute carrier (SLC) transporters that participate in the import and efflux of ions, amino acids, sugars, and cofactors required for metabolism. However, over 30% of
these SLCs are uncharacterized or poorly understood. Our research group is currently developing better molecular biology, imaging, and metabolomics tools that aim to advance our understanding of the function, localization, and cooperativity of amino acid transporters through uncoupling of transport from intracellular metabolism.
The metabolic pathways that comprise eukaryotic metabolism are compartmentalized into distinct and specialized organelles (e.g. mitochondria, lysosomes, peroxisomes). Current metabolomics methods that extract bulk cellular metabolites fail to capture the compartmentalization of
intracellular metabolism. Our group aims to develop better methods to interrogate compartmentalized metabolic pathways. In this vein, we hope to understand how expression of specific enzyme isoforms may offer a selective advantage for cancer cells.
American Cancer Society Postdoctoral Fellowship (2019-2020)
Siebel Scholar (2016)
Achievement Reward for College Scientists (2016)
Every day, our researchers work towards breakthroughs to transform the lives of kids in BC and around the world. Learn about our latest innovations and advancements in child health.
While growing up, Abisola Kehinde was fascinated by biology, one of those courses she didn’t have to study much to easily understand. It was natural to her, so choosing a career in science was a no-brainer. She was never told that, as a woman, there wasn’t space for her in this field. But there were…
Dr. Michael Kobor has been awarded the 2022 Geoffrey L. Hammond Lectureship. The former, and inaugural, director of the Healthy Starts Research Theme at BC Children’s Hospital Research Institute (BCCHR), senior scientist at the Centre for Molecular Medicine and Therapeutics (CMMT) and professor at The University of British Columbia (UBC) was nominated for his pioneering…
Congratulations to the BC Children's Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded funding through the Canadian Institutes of Health Research (CIHR) Fall 2021 Project Grant competition. Our research community received around $6 million in new research grants as principal investigators or co-investigators.
At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.
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BC Children's Hospital Research Institute operates on the ancestral and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. Further, this acknowledgement, gratitude, and respect extends to all of the First Nations communities on whose territories the Research Institute builds relationships and operates in British Columbia.
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