Kyla Hildebrand

MD, FRCPC, MScCH

Investigator, BC Children's Hospital

My research interests are in the area of Allergy and Clinical Immunology. The immune system plays a critical role in protecting hosts from infection. Primary immunodeficiency encompasses a group of disorders whereby parts of the immune system may be defective or missing, often resulting in severe, invasive or recurrent infections, autoimmunity and malignancy. The genetic makeup of an individual and the response of the immune system to external environmental factors can result in allergic disorders and disease. There is a strong relationship between conditions such as asthma, food allergy and atopic dermatitis - all of which have an underlying immunological basis. My research aims to study these disorders and apply knowledge translation strategies to empower patients, families and their physicians.

Academic Affiliations

  • Clinical Associate Professor, Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

ASXL1 deficiency causes epigenetic dysfunction, combined immunodeficiency, and EBV-associated lymphoma

Journal of Experimental Medicine

Fu, M.P. and Sharma, M. and Yousefi, P. and Merrill, S.M. and Tan, R. and Samra, S. and Setiadi, A. and Golding, L. and Modi, B.P. and Del Bel, K.L. and Deyell, R.J. and Rozmus, J. and Rehmus, W. and Hildebrand, K.J. and James, E. and Blanchard-Rohner, G. and Lin, S. and Shopsowitz, K.E. and Terry, J. and Lee, A.F. and Dr{\"o}gem{\"o}ller, B.I. and Matthews, A. and Tarailo-Graovac, M. and Sauv{\'e}, L. and Mitchell, H. and Prendiville, J.S. and MacIsaac, J.L. and Dever, K. and Lin, D.T.S. and Meijer, M. and Ross, C.J.D. and Dobson, S.R.M. and Vercauteren, S.M. and Wasserman, W.W. and van Karnebeek, C.D.M. and McKinnon, M.L. and Kobor, M.S. and Turvey, S.E. and Biggs, C.M.

DOI: 10.1084/jem.20240945

A Germline Heterozygous Dominant Negative IKZF2 Variant Causing Syndromic Primary Immune Regulatory Disorder and ICHAD

Journal of Clinical Immunology

Lu, H.Y. and Vaseghi-Shanjani, M. and Lam, A.J. and Sharma, M. and Mohajeri, A. and Silva, L.B.R. and Gillies, J. and Yang, G.X. and Lin, S. and Fu, M.P. and Salman, A. and Rahmanian, R. and Armstrong, L. and Halparin, J. and Yang, C.L. and Chilvers, M. and Henkelman, E. and Rehmus, W. and Morrison, D. and Setiadi, A. and Mostafavi, S. and Kobor, M.S. and Kozak, F.K. and Biggs, C.M. and van Karnebeek, C. and Hildebrand, K.J. and Levings, M.K. and Turvey, S.E.

DOI: 10.1007/s10875-025-01882-2

The changing epidemiology of paediatric childhood asthma and allergy in different regions of the world

Frontiers in Allergy

Adamko, D.J. and Hildebrand, K.J.

DOI: 10.3389/falgy.2025.1584928

A multimorphic variant in ThPOK causes an inborn error of immunity with T cell defects and fibrosis

Journal of Experimental Medicine

Vaseghi-Shanjani, M. and Sharma, M. and Yousefi, P. and Samra, S. and Laverty, K.U. and Jolma, A. and Razavi, R. and Yang, A.H.W. and Albu, M. and Golding, L. and Lee, A.F. and Tan, R. and Richmond, P.A. and Bosticardo, M. and Rayment, J.H. and Yang, C.L. and Hildebrand, K.J. and Brager, R. and Demos, M.K. and Lau, Y.-L. and Notarangelo, L.D. and Hughes, T.R. and Biggs, C.M. and Turvey, S.E.

DOI: 10.1084/jem.20241174

Evaluating family-centred care at BC Children's Hospital: Healthcare providers' perspectives

Journal of Evaluation in Clinical Practice

Kolar, T. and Cook, C.B. and Cooper, A. and Blydt-Hansen, T. and Connolly, M.B. and Boelman, C. and Chhina, H. and Datta, A. and Demos, M. and Hildebrand, K.J. and Selby, K. and Shen, Y. and Wenderfer, S.E. and Elliott, A.M.

DOI: 10.1111/jep.14187

A multimorphic variant in ThPOK causes a novel human disease characterized by T cell abnormalities, immunodysregulation, allergy, and fibrosis

medRxiv

Vaseghi-Shanjani, M. and Sharma, M. and Yousefi, P. and Samra, S. and Laverty, K.U. and Jolma, A. and Razavi, R. and Yang, A.H.W. and Albu, M. and Golding, L. and Lee, A.F. and Tan, R. and Richmond, P.A. and Bosticardo, M. and Rayment, J.H. and Yang, C.L. and Hildebrand, K.J. and Brager, R. and Demos, M.K. and Lau, Y.L. and Notarangelo, L.D. and Hughes, T.R. and Biggs, C.M. and Turvey, S.E.

DOI: 10.1101/2024.06.26.24309360

Vaccination and egg allergy: Considerations for family physicians,La vaccination et lallergie aux 'ufs Facteurs que devraient considrer les mdecins de famille

Canadian Family Physician

Abrams, E.M. and Zafack, J.G. and Jensen, C. and Bettinger, J.A. and Top, K.A. and Hildebrand, K.J. and Tunis, M.C.

DOI: 10.46747/cfp.700113

Inborn errors of immunity (primary immunodeficiencies)

Allergy Asthma and Clinical Immunology

Kim, V.H.D. and Upton, J.E.M. and Derfalvi, B. and Hildebrand, K.J. and McCusker, C.

DOI: 10.1186/s13223-024-00938-z

Cost-effectiveness analysis of 21-valent pneumococcal conjugated vaccine among adults in Canada

Medrxiv

Ximenes, R. and Simmons, A.E. and Gebretekle, G.B. and Nam, A. and Wong, E. and Salvadori, M.I. and Golden, A.R. and Sander, B. and Hildebrand, K.J. and Tunis, M. and Tuite, A.R.

DOI: 10.1101/2024.10.21.24315770

Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency

Pediatric Allergy and Immunology

Duke, S. and Maiarana, J. and Yousefi, P. and Burks, E. and Gerrie, S. and Setiadi, A. and Amid, A. and Boerkel, C. and Erdle, S. and Guttman, O. and Kanani, A. and Lawrence, S. and Lee, A.F. and Pourshahnazari, P. and Rayar, M. and Rozmus, J. and Schrader, D. and Sharma, M. and Shopsowitz, K.E. and Tan, R. and To, F. and Yang, C. and Hildebrand, K.J. and James, E. and Turvey, S.E. and Markle, J.G. and Biggs, C.M.

DOI: 10.1111/pai.14077

Should primary immune disorder replace inborn error of immunity? Names matter, but there is room for both

Journal of Allergy and Clinical Immunology

Turvey, S.E. and Biggs, C.M. and James, E.L. and Hildebrand, K.J.

DOI: 10.1016/j.jaci.2024.04.007

Revaccination outcomes among adolescents and adults with suspected hypersensitivity reactions following COVID-19 vaccination: A Canadian immunization research network study

Vaccine

Fitzpatrick, T. and Yamoah, P. and Lacuesta, G. and Sadarangani, M. and Cook, V. and Pourshahnazari, P. and Kalicinsky, C. and Upton, J.E.M. and Cameron, S.B. and Zaborniak, K. and Kanani, A. and Lam, G. and Burton, C. and Constantinescu, C. and Pernica, J.M. and Abdurrahman, Z. and Betschel, S. and Drolet, J.-P. and De Serres, G. and Quach, C. and Des Roches, A. and Chapdelaine, H. and Salvadori, M.I. and Carignan, A. and McConnell, A. and Pham-Huy, A. and Buchan, C.A. and Cowan, J. and Hildebrand, K. and Top, K.A.

DOI: 10.1016/j.vaccine.2024.06.045

Inborn errors of immunity in adulthood

Allergy, Asthma and Clinical Immunology

Wang, J.J.F. and Dhir, A. and Hildebrand, K.J. and Turvey, S.E. and Schellenberg, R. and Chen, L.Y.C. and Pourshahnazari, P. and Biggs, C.M.

DOI: 10.1186/s13223-023-00862-8

Vaccination and egg allergy

Canadian Family Physician

Abrams, E.M. and Zafack, J.G. and Jensen, C. and Bettinger, J.A. and Top, K.A. and Hildebrand, K.J. and Tunis, M.C.

DOI: 10.46747/cfp.700110

Vaccination contre la rougeole

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Jeimy, S. and Hildebrand, K.J. and Vohra-Miller, S.

DOI: 10.1503/cmaj.240371-f

Measles vaccination

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Jeimy, S. and Hildebrand, K.J. and Vohra-Miller, S.

DOI: 10.1503/cmaj.240371

Introduction to immunology and immune disorders

Allergy Asthma and Clinical Immunology

Marshall, J.S. and Upton, J.E.M. and Vliagoftis, H. and Hildebrand, K.J. and Byrne, A. and Watson, W.

DOI: 10.1186/s13223-024-00932-5

A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency

Science Immunology

Fornes, O. and Jia, A. and Kuehn, H.S. and Min, Q. and Pannicke, U. and Schleussner, N. and Thouenon, R. and Yu, Z. and de los Angeles Astbury, M. and Biggs, C.M. and Galicchio, M. and Garcia-Campos, J.A. and Gismondi, S. and Villarreal, G.G. and Hildebrand, K.J. and Hnig, M. and Hou, J. and Moshous, D. and Pittaluga, S. and Qian, X. and Rozmus, J. and Schulz, A.S. and Staines-Boone, A.T. and Sun, B. and Sun, J. and Uwe, S. and Venegas-Montoya, E. and Wang, W. and Wang, X. and Ying, W. and Zhai, X. and Zhou, Q. and Akalin, A. and Andr, I. and Barth, T.F.E. and Baumann, B. and Brstle, A. and Burgio, G. and Bustamante, J.C. and Casanova, J.-L. and Casarotto, M.G. and Cavazzana, M. and Chentout, L. and Cockburn, I.A. and Costanza, M. and Cui, C. and Daumke, O. and Del Bel, K.L. and Eibel, H. and Feng, X. and Franke, V. and Gebhardt, J.C.M. and Gtz, A. and Grunwald, S. and Hoareau, B. and Hughes, T.R. and Jacobsen, E.-M. and Janz, M. and Jolma, A. and Lagresle-Peyrou, C. and Lai, N. and Li, Y. and Lin, S. and Lu, H.Y. and Lugo-Reyes, S.O. and Meng, X. and Mller, P. and Moreno-Corona, N. and Niemela, J.E. and Novakovsky, G. and Perez-Caraballo, J.J. and Picard, C. and Poggi, L. and Puig-Lombardi, M.-E. and Randall, K.L. and Reisser, A. and Schmitt, Y. and Seneviratne, S. and Sharma, M. and Stoddard, J. and Sundararaj, S. and Sutton, H. and Tran, L.Q. and Wang, Y. and Wasserman, W.W. and Wen, Z. and Winkler, W. and Xiong, E. and Yang, A.W.H. and Yu, M. and Zhang, L. and Zhang, H. and Zhao, Q. and Zhen, X. and Enders, A. and Kracker, S. and Martinez-Barricarte, R. and Mathas, S. and Rosenzweig, S.D. and Schwarz, K. and Turvey, S.E. and Wang, J.-Y.

DOI: 10.1126/sciimmunol.ade7953

Trends in the proportion of women speakers at North American Allergy and Immunology conferences, 2008 to 2020

Annals of Allergy, Asthma and Immunology

Hunt, K.M. and Foley, M. and Connors, L.A. and Hildebrand, K.J. and Ellis, A.K.

DOI: 10.1016/j.anai.2023.08.607

Homozygous RMRP Promoter Duplications Cause Severely Reduced Transcript Abundance and SCID Associated with Cartilage Hair Hypoplasia

Journal of Clinical Immunology

Tan, R. and Lu, H.Y. and Sharma, M. and Sandhu, H. and Harris, K.C. and Cameron, S.B. and Setiadi, A. and Hildebrand, K.J. and Rozmus, J. and Turvey, S.E. and Biggs, C.M.

DOI: 10.1007/s10875-023-01489-5

Vaccine anaphylaxis and Canadian public health policy

The Lancet Respiratory Medicine

Abrams, E.M. and Zafack, J.G. and Ismail, S.J. and Bettinger, J.A. and Hildebrand, K.J. and Tunis, M.C.

DOI: 10.1016/S2213-2600(23)00037-1

Cow's milk alternatives for children with cow's milk allergy and beyond

Paediatrics and Child Health Canada

Williams, B.A. and Erdle, S.C. and Cochrane, K.M. and Wingate, K. and Hildebrand, K.J.

DOI: 10.1093/pch/pxac076

Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay

Journal of Medical Genetics

Mohajeri, A. and Vaseghi-Shanjani, M. and Rosenfeld, J.A. and Yang, G.X. and Lu, H. and Sharma, M. and Lin, S. and Salman, A. and Waqas, M. and Sababi Azamian, M. and Worley, K.C. and Del Bel, K.L. and Kozak, F.K. and Rahmanian, R. and Biggs, C.M. and Hildebrand, K.J. and Lalani, S.R. and Nicholas, S.K. and Scott, D.A. and Mostafavi, S. and Van Karnebeek, C. and Henkelman, E. and Halparin, J. and Yang, C.L. and Armstrong, L. and Turvey, S.E. and Lehman, A.

DOI: 10.1136/jmg-2022-109127

Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia

Journal of Experimental Medicine

Garca-Garca, A. and de Diego, R.P. and Flores, C. and Rinchai, D. and Sol-Violn, J. and Dey-Martnez, ?. and Garca-Solis, B. and Lorenzo-Salazar, J.M. and Hernndez-Brito, E. and Lanz, A.-L. and Moens, L. and Bucciol, G. and Almuqamam, M. and Domachowske, J.B. and Colino, E. and Santos-Perez, J.L. and Marco, F.M. and Pignata, C. and Bousfiha, A. and Turvey, S.E. and Bauer, S. and Haerynck, F. and Ocejo-Vinyals, J.G. and Lendinez, F. and Prader, S. and Naumann-Bartsch, N. and Schmid, J.P. and Biggs, C.M. and Hildebrand, K. and Dreesman, A. and Crdenes, M.?. and Ailal, F. and Benhsaien, I. and Giardino, G. and Molina-Fuentes, A. and Fortuny, C. and Madhavarapu, S. and Conway, D.H. and Prando, C. and Schidlowski, L. and de Saavedra lvarez, M.T.M. and Alfaro, R. and de Castro, F.R. and Meyts, I. and Hauck, F. and Puel, A. and Bastard, P. and Boisson, B. and Jouanguy, E. and Abel, L. and Cobat, A. and Zhang, Q. and Casanova, J.-L. and Alsina, L. and Rodrguez-Gallego, C. and Aiuti, A. and Al-Muhsen, S. and Al-Mulla, F. and Anderson, M.S. and Andreakos, E. and Arias, A.A. and Feldman, H.B. and Belot, A. and Bogunovic, D. and Bolze, A. and Bondarenko, A. and Bousfiha, A.A. and Brodin, P. and Bryceson, Y. and Bustamante, C.D. and Butte, M.J. and Casari, G. and Christodoulou, J. and Condino-Neto, A. and Constantinescu, S.N. and Cooper, M.A. and Dalgard, C.L. and Desai, M. and Drolet, B.A. and Baghdadi, J.E. and Espinosa-Padilla, S. and Fellay, J. and Franco, J.L. and Froidure, A. and Gregersen, P.K. and Grimbacher, B. and Hagin, D. and Halwani, R. and Hammarstrm, L. and Heath, J.R. and Henrickson, S.E. and Hsieh, E.W.Y. and Husebye, E. and Imai, K. and Itan, Y. and Jarvis, E.D. and Karamitros, T. and Kisand, K. and Ku, C.-L. and Lau, Y.-L. and Ling, Y. and Lucas, C.L. and Maniatis, T. and Mansouri, D. and Mardi, L. and Milner, J.D. and Mironska, K. and Mogensen, T.H. and Morio, T. and Ng, L.F.P. and Notarangelo, L.D. and Novelli, A. and Novelli, G. and O'farrelly, C. and Okada, S. and Okamoto, K. and Ozcelik, T. and Pan-Hammarstrm, Q. and Pape, J.W. and de Diego, R.P. and Perlin, D.S. and Pesole, G. and Planas, A.M. and Pujol, A. and Quintana-Murci, L. and Ramaswamy, S. and Renia, L. and Resnick, I. and Sancho-Shimizu, V. and Sediva, A. and Seppnen, M.R.J. and Shahrooei, M. and Shcherbina, A. and Slaby, O. and Snow, A.L. and Soler-Palacn, P. and Spaan, A.N. and Tancevski, I. and Tangye, S.G. and Tayoun, A.A. and Uddin, K.M.F. and Uddin, M.J. and van de Beek, D. and Vinh, D.C. and von Bernuth, H. and Wauters, J. and Zatz, M. and Zawadzki, P. and Su, H.C. and Kindle, G. and Mahlaoui, N. and Seidel, M.G. and Vassilios, L.

DOI: 10.1084/jem.20220170

Human ASXL1 Deficiency Causes Epigenetic Dysfunction, Combined Immunodeficiency and EBV"Associated Hodgkin Lymphoma

medRxiv

Fu, M.P. and Sharma, M. and Merrill, S.M. and Yousefi, P. and Tan, R. and Modi, B.P. and Bel, K.D. and Deyell, R.J. and Rozmus, J. and Rehmus, W. and Hildebrand, K.J. and James, E. and Blanchard-Rohner, G. and Lin, S. and Shopsowitz, K.E. and Setiadi, A. and Terry, J. and Lee, A.F. and Drgemller, B.I. and Matthews, A. and Tarailo-Graovac, M. and Sauv, L. and Mitchell, H. and Prendiville, J.S. and MacIsaac, J.L. and Dever, K. and Lin, D.T.S. and Meijer, M. and Ross, C.J.D. and Dobson, S.R.M. and Vercauteren, S.M. and Wasserman, W.W. and van Karnebeek, C.D.M. and McKinnon, M.L. and Kobor, M.S. and Turvey, S.E. and Biggs, C.M.

DOI: 10.1101/2023.12.20.23300096

Evaluation of rotavirus vaccine administration among a 22q11.2DS patient population

Allergy, Asthma & Clinical Immunology

Sophie McGregor and Matthew Boroditsky and Geraldine Blanchard-Rohner and Christine Loock and Kyla Jade Hildebrand

DOI: 10.1186/s13223-022-00693-z

12 / 2022

Real-world peanut OIT in infants may be safer than non-infant preschool OIT and equally effective

Journal of Allergy and Clinical Immunology: In Practice

Soller, L. and Carr, S. and Kapur, S. and Rex, G.A. and McHenry, M. and Cook, V.E. and Leo, S. and Wong, T. and Vander Leek, T.K. and Gerstner, T.V. and Yeung, J. and Abrams, E.M. and Mak, R. and Hildebrand, K.J. and Erdle, S.C. and Cameron, S.B. and Chan, E.S.

DOI: 10.1016/j.jaip.2021.12.009

Revaccination and Adverse Event Recurrence in Patients with Adverse Events following Immunization

Journal of Pediatrics

Mu{\~n}oz, C.E. and MacDonald, B. and Pham-Huy, A. and Vaudry, W. and Pernica, J.M. and Boucher, F.D. and Constantinescu, C. and Sadarangani, M. and Bettinger, J.A. and Tapi{\'e}ro, B. and Morris, S.K. and McConnell, A. and Cowan, J. and Zafack, J. and Upton, J. and Abdurrahman, Z. and McHenry, M. and Hildebrand, K.J. and Noya, F. and De Serres, G. and Halperin, S.A. and Top, K.A.

DOI: 10.1016/j.jpeds.2022.07.019

Diverse clinical features and diagnostic delay in monogenic inborn errors of immunity: A call for access to genetic testing

Pediatric Allergy and Immunology

Branch, A. and Modi, B. and Bahrani, B. and Hildebrand, K.J. and Cameron, S.B. and Junker, A.K. and Turvey, S.E. and Biggs, C.M.

DOI: 10.1111/pai.13571

CSACI position statement: transition recommendations on existing epinephrine autoinjectors

Allergy, Asthma and Clinical Immunology

Li, L.D.X. and Abrams, E.M. and Lavine, E. and Hildebrand, K. and Mack, D.P.

DOI: 10.1186/s13223-021-00634-2

Anaphylaxis to parenteral nutrition in a pediatric oncology patient treated with induction of drug tolerance protocol

Journal of Allergy and Clinical Immunology: In Practice

Wachnian, C.J. and Baadjes, B. and Cheng, S. and Ramanzin, A. and Hildebrand, K.J.

DOI: 10.1016/j.jaip.2020.10.016

Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report

BMC Pediatrics

Blanchard-Rohner, G. and Ragotte, R.J. and Junker, A.K. and Sharma, M. and Del Bel, K.L. and Lu, H.Y. and Erdle, S. and Chomyn, A. and Gill, H. and Tucker, L.B. and Schreiber, R.A. and Rozmus, J. and Biggs, C.M. and Hildebrand, K.J. and Wu, J. and Stockler-Ipsiroglu, S. and Turvey, S.E.

DOI: 10.1186/s12887-021-02508-3

Evaluation and management of non-IgE-mediated food allergies,L'valuation et la prise en charge des allergies alimentaires non induites par les IgE

Paediatrics and Child Health (Canada)

Abrams, E.M. and Hildebrand, K.J. and Chan, E.S.

DOI: 10.1093/pch/pxaa132

Non-IgE-mediated food allergy: Evaluation and management

Paediatrics and Child Health (Canada)

Abrams, E.M. and Hildebrand, K.J. and Chan, E.S.

DOI: 10.1093/pch/pxaa131

Septic arthritis due to Mycoplasma orale in a young patient with hypogammaglobulinemia

JAMMI

Liu, A.C. and Harvey, M. and Lee, A. and Hildebrand, K. and Hoang, L. and Gantt, S. and Al-Rawahi, G.N.

DOI: 10.3138/JAMMI-2021-0002

Inborn errors of immunity manifesting as atopic disorders

Journal of Allergy and Clinical Immunology

Vaseghi-Shanjani, M. and Smith, K.L. and Sara, R.J. and Modi, B.P. and Branch, A. and Sharma, M. and Lu, H.Y. and James, E.L. and Hildebrand, K.J. and Biggs, C.M. and Turvey, S.E.

DOI: 10.1016/j.jaci.2021.08.008

First Real-World Effectiveness Analysis of Preschool Peanut Oral Immunotherapy

Journal of Allergy and Clinical Immunology: In Practice

Soller, L. and Abrams, E.M. and Carr, S. and Kapur, S. and Rex, G.A. and Leo, S. and McHenry, M. and Vander Leek, T.K. and Yeung, J. and Cook, V.E. and Wong, T. and Hildebrand, K.J. and Mak, R. and Gerstner, T.V. and Cameron, S.B. and Chan, E.S.

DOI: 10.1016/j.jaip.2020.10.045

Prevention and management of allergic reactions to food in child care centers and schools: Practice guidelines

Journal of Allergy and Clinical Immunology

Waserman, S. and Cruickshank, H. and Hildebrand, K.J. and Mack, D. and Bantock, L. and Bingemann, T. and Chu, D.K. and Cuello-Garcia, C. and Ebisawa, M. and Fahmy, D. and Fleischer, D.M. and Galloway, L. and Gartrell, G. and Greenhawt, M. and Hamilton, N. and Hourihane, J. and Langlois, M. and Loh, R. and Muraro, A. and Rosenfield, L. and Schoessler, S. and Tang, M.L.K. and Weitzner, B. and Wang, J. and Brozek, J.L.

DOI: 10.1016/j.jaci.2021.01.034

First pediatric electronic algorithm to stratify risk of penicillin allergy

Allergy, Asthma and Clinical Immunology

Roberts, H. and Soller, L. and Ng, K. and Chan, E.S. and Roberts, A. and Kang, K. and Hildebrand, K.J. and Wong, T.

DOI: 10.1186/s13223-020-00501-6

Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) Syndrome

Encyclopedia of Medical Immunology Immunodeficiency Diseases

Hildebrand, K.J.

DOI: 10.1007/978-1-4614-8678-7_49

Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant

Cold Spring Harbor Molecular Case Studies

Jia, A. and James, E. and Lu, H.Y. and Sharma, M. and Modi, B.P. and Biggs, C.M. and Hildebrand, K.J. and Chomyn, A. and Erdle, S. and Kular, H. and Turvey, S.E.

DOI: 10.1101/MCS.A005298

Timing of introduction of allergenic solids for infants at high risk.

Paediatrics & Child Health

Abrams EM and Hildebrand K and Blair B and Chan ES

DOI: 10.1093/pch/pxy195 PubMed: 30833823

02 / 2019

First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy

Journal of Allergy and Clinical Immunology: In Practice

Soller, L. and Abrams, E.M. and Carr, S. and Kapur, S. and Rex, G.A. and Leo, S. and Lidman, P.G. and Yeung, J. and Vander Leek, T.K. and McHenry, M. and Wong, T. and Cook, V.E. and Hildebrand, K.J. and Gerstner, T.V. and Mak, R. and Lee, N.J. and Cameron, S.B. and Chan, E.S.

DOI: 10.1016/j.jaip.2019.04.010

Extended analysis of parent and child confidence in recognizing anaphylaxis and using the epinephrine autoinjector during oral food challenges

Journal of Allergy and Clinical Immunology: In Practice

Soller, L. and Teoh, T. and Baerg, I. and Wong, T. and Hildebrand, K.J. and Cook, V.E. and Biggs, C.M. and Lee, N. and Yaworski, L. and Cameron, S.B. and Chan, E.S.

DOI: 10.1016/j.jaip.2018.09.025

Supervised epinephrine autoinjector administration in a cohort of children with anaphylaxis during oral food challenges (OFCs)

Journal of Allergy and Clinical Immunology

Lianne Soller and Timothy Teoh and Ingrid Baerg and Tracy Gonzalez and Tiffany Wong and Kyla J. Hildebrand and Edmond S. Chan

DOI: 10.1016/j.jaci.2017.12.800

02 / 2018

Early introduction of foods to prevent food allergy

Allergy, Asthma and Clinical Immunology

Chan, E.S. and Abrams, E.M. and Hildebrand, K.J. and Watson, W.

DOI: 10.1186/s13223-018-0286-1

Asthma

Allergy, Asthma and Clinical Immunology

Quirt, J. and Hildebrand, K.J. and Mazza, J. and Noya, F. and Kim, H.

DOI: 10.1186/s13223-018-0279-0

Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency

LymphoSign Journal

Victoria Elizabeth Cook and Connie L Yang and Alexia Dabadie and Joanne Luider and Kyla Jade Hildebrand and Anne K Junker and Stuart Turvey

DOI: 10.14785/lymphosign-2017-0003

06 / 2017

THE PHENOTYPE OF SEVERE PRESCHOOL ASTHMATICS AND THEIR RESPONSE TO ADD-ON THERAPY.

Paediatrics & Child Health

Seaton C and Hildebrand K and Pow A and Yang C

DOI: 10.1093/pch/pxx086.094

05 / 2017

Many Children Referred to a Tertiary Care Pediatric Allergy Clinic Do Not Have an Allergy

Journal of Allergy and Clinical Immunology

Victoria E. Cook and Jordan Yeo and Christopher Mill and Kyla Hildebrand and Elodie Portales-Casamar and Edmond S. Chan

DOI: 10.1016/j.jaci.2016.12.134

02 / 2017

Determinants of Quality of life (QOL) Among Children Undergoing Oral Food Challenge (OFC) in Canada

Journal of Allergy and Clinical Immunology

Lianne Soller and Christopher Mill and Tiffany Wong and Ingrid Baerg and Tracy Gonzalez and Timothy Teoh and Kyla Hildebrand and Edmond S. Chan

DOI: 10.1016/j.jaci.2016.12.137

02 / 2017

Primum non nocere-first do no harm. And then feed peanut

Allergy, Asthma and Clinical Immunology

Hildebrand, K.J. and Abrams, E.M. and Vander Leek, T.K. and Upton, J.E.M. and Mack, D.P. and Kirste, L. and McCusker, C. and Kapur, S.

DOI: 10.1186/s13223-017-0180-2

Persistent fever in an 8-month-old boy

Pediatrics in Review

Kilvert, M. and Roberts, A. and Hildebrand, K.J.

DOI: 10.1542/pir.2015-0145

IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae

Clinical Immunology

Grazioli, S. and Hamilton, S.J. and McKinnon, M.L. and Del Bel, K.L. and Hoang, L. and Cook, V.E. and Hildebrand, K.J. and Junker, A.K. and Turvey, S.E.

DOI: 10.1016/j.clim.2015.12.007

Impact of supervised epinephrine autoinjector administration during food challenges on parent confidence

Annals of Allergy, Asthma and Immunology

Teoh, T. and Mill, C. and Wong, T. and Baerg, I. and Alexander, A. and Hildebrand, K.J. and Dean, J. and Kuzeljevic, B. and Chan, E.S.

DOI: 10.1016/j.anai.2016.02.020

Mobile health applications in clinical practice: pearls, pitfalls, and key considerations

Annals of Allergy, Asthma and Immunology

Cook, V.E. and Ellis, A.K. and Hildebrand, K.J.

DOI: 10.1016/j.anai.2016.01.012

Epinephrine auto injector administration by parents or patients for anaphylaxis during supervised oral food challenges and assessment of confidence

Allergy, Asthma and Clinical Immunology

Baerg, I. and Alexander, A. and Wong, T. and Teoh, T. and Hildebrand, K. and Leo, S. and Yeung, J. and Dean, J. and Chan, E.

DOI: 10.1186/1710-1492-10-S2-A2

Rifampin hypersensitivity in a 2-year-old child with successful rapid oral desensitization

Pediatric Infectious Disease Journal

Hildebrand, K.J. and Atkinson, A. and Kitai, I.

DOI: 10.1097/INF.0000000000000295

Limitation of TREC-based newborn screening for ZAP70 Severe Combined Immunodeficiency

Clinical Immunology

Grazioli, S. and Bennett, M. and Hildebrand, K.J. and Vallance, H. and Turvey, S.E. and Junker, A.K.

DOI: 10.1016/j.clim.2014.04.015

Human primary immunodeficiencies causing defects in innate immunity

Current Opinion in Allergy and Clinical Immunology

Wong, T. and Yeung, J. and Hildebrand, K.J. and Junker, A.K. and Turvey, S.E.

DOI: 10.1097/ACI.0000000000000010

Vasculitis masquerading as drug allergy: thinking outside the adult box of possible diagnoses

Allergy, Asthma & Clinical Immunology

Marie-Elodie Sarre-Annweiler and Mariamma Joseph and Kyla J Hildebrand

DOI: 10.1186/1710-1492-8-s1-a15

Rifampin hypersensitivity in a two year-old child with successful rapid oral desensitization

Allergy, Asthma & Clinical Immunology

KJ Hildebrand and D Hummel

DOI: 10.1186/1710-1492-6-s1-p22

Epinephrine Autoinjector Study

Caregivers and patients in Pediatric Allergy Clinic often report that they are fearful of using an epinephrine autoinjector despite receiving education on indications for use and technique. Given that intramuscular epinephrine is the only medication that can reverse a potentially severe allergic reaction, it is very important that patients and caregivers possess not only the knowledge and ability to use epinephrine autoinjectors, but also have the confidence to administer the medication when clinically indicated. The goal of the Epinephrine Autoinjector study is to assess the impact of self or caregiver-administrated epinephrine in a medically supervised setting on the confidence of patient and/or caregivers for future use of epinephrine autoinjector.

Certified Asthma Educator (CAE) Anaphylaxis Counseling Study

Several of my research projects involve studying the relationship between asthma, allergy and anaphylaxis. Many patients with severe asthma who require admission to intensive care units or repeated hospital admissions have underlying allergic triggers (environmental or food allergy). Poorly controlled asthma is a significant risk factor for anaphylaxis in this patient population. I am assessing the frequency of anaphylaxis counseling performed by a group of CAEs at BC Children’s Hospital and the outcomes associated with this counseling intervention. For patients living in remote areas of British Columbia, there is greater accessibility to CAEs in comparison to pediatric asthma/allergy specialists. There may be a role for curricular innovation to the CAE training programs across Canada to better serve this at-risk patient population.

The CHILD study

this study is a multicenter, multidisciplinary, longitudinal, population-based cohort study of 5000 children. The aim of the study is to test multiple hypotheses within the theme that specific environmental exposures along with genetic and immunological determinants, lead to pathophysiological allergic responses, and that clinical outcomes including asthma may be further modified by lung growth, hormonal and metabolic influences and psychosocial environment. Children were recruited from 4 cities in Canada, including Vancouver and are being followed prospectively.

Honours & Awards

Royal College of Physicians and Surgeons Canada Fellowship for Studies in Medical Education (2010)

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