Bruce A Vallance

Biopsy-derived colonoid air-liquid interface monolayers reveal persistent mucosal defects in ulcerative colitis patients

Bruce Vallance and Ashley Gilliland and Yan Chen and Irvin Ng and Xiao Han and Ho Pan Sham and Itay Kalisky and Dominique Lvesque and Kevan Jacobson and Wei Xiong and Franois-Michel Boisvert and Brian Bressler

12 / 2025

Differential roles for Irgm1 in myeloid cells for immune resistance to pathogenic bacteria

Journal of Leukocyte Biology

Brian E Fee and Lanette R Fee and Aemilia R Sprouse and Bruce A Vallance and Prashant Rai and Michael B Fessler and Yue Xue and Hsin-I Huang and Gianna E Hammer and Gregory A Taylor

12 / 2025

Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model

Frontiers in Immunology

Sharafian, Z. and Littlejohn, P.T. and Michalski, C. and Sousa, J.A. and Cheung, J. and Hill, M. and Piper, H. and Jacobson, K. and Lavoie, P.M. and Allaire, J.M. and Vallance, B.A.

The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential

Gut Microbes

Jimenez-Sanchez, M. and Celiberto, L.S. and Yang, H. and Sham, H.P. and Vallance, B.A.

Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn's Disease

Gastroenterology

Olivera, P.A. and Martinez-Lozano, H. and Leibovitzh, H. and Xue, M. and Neustaeter, A. and Espin-Garcia, O. and Xu, W. and Madsen, K.L. and Guttman, D.S. and Bernstein, C.N. and Yerushalmi, B. and Hyams, J.S. and Abreu, M.T. and Marshall, J.K. and Wrobel, I. and Mack, D.R. and Jacobson, K. and Bitton, A. and Aumais, G. and Panacionne, R. and Dieleman, L.A. and Silverberg, M.S. and Steinhart, A.H. and Moayyedi, P. and Turner, D. and Griffiths, A.M. and Turpin, W. and Lee, S.-H. and Croitoru, K. and Beck, P. and Feagan, B. and Griffiths, A. and Kaplan, G. and Krause, D.O. and Ropeleski, M. and Seidman, E. and Snapper, S. and Stadnyk, A. and Surette, M. and Walters, T. and Vallance, B. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H.Q. and McGrath, J. and Otley, A. and Panaccione, R.

Development and Validation of an Integrative Risk Score for Future Risk of Crohn's Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study

Gastroenterology

Lee, S.-H. and Turpin, W. and Espin-Garcia, O. and Xu, W. and Croitoru, K. and Leibovitzh, H. and Xue, M. and Raygoza Garay, J.A. and Gra{\~n}a-Miraglia, L. and Smith, M.I. and Goethel, A. and Madsen, K.L. and Avni-Biron, I. and Dotan, I. and Weiss, B. and Panaccione, R. and Huynh, H. and Jacobson, K. and Aumais, G. and Mack, D. and Griffiths, A.M. and Steinhart, A.H. and Silverberg, M.S. and Turner, D. and Bernstein, C.N. and Feagan, B.G. and Moayyedi, P. and Paterson, A. and Guttman, D.S. and Abreu, M. and Beck, P. and Dieleman, L. and Kaplan, G. and Krause, D.O. and Marshall, J. and Ropeleski, M. and Seidman, E. and Snapper, S. and Stadnyk, A. and Surette, M. and Walters, T. and Vallance, B. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Hyams, J. and McGrath, J. and Otley, A.

TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation

Cell Reports Medicine

Tuomela, K. and Garcia, R.V. and Boardman, D.A. and Tavakoli, P. and Ancheta-Schmit, M. and Sham, H.P. and Cheng, L. and Struthers, M. and Bressler, B. and Vallance, B.A. and Zhao, Q. and Levings, M.K.

Fasting elicits gut microbiome signature changes that extend to type 1 diabetes patients

Frontiers in Endocrinology

Graef, F.A. and Berger, B. and Bahr, L.S. and Stange, R. and Michalsen, A. and Paul, F. and Vallance, B.A. and Jacobson, K.

Development of novel GI-centric prostaglandin E2 receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases

Bioorganic and Medicinal Chemistry Letters

Kantham, S. and Yu, H. and Cantelli, C.R. and Chen, G. and Ma, C. and Chan, J.J. and Yang, H. and Tsai, K. and Lassueur, K. and Vallance, B.A. and Jacobson, K. and Young, R.N.

Early Life Exposure to Parental Crohn's Disease Is Associated With Offspring's Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn's Disease

Gastroenterology

Lee, S.-H. and Bushra, M. and Qiu, L. and Griffiths, A.M. and Turpin, W. and Croitoru, K. and Shao, J. and Olivera, P.A. and Leibovitzh, H. and Xue, M. and Xu, W. and Espin-Garcia, O. and Amuais, G.L. and Huynh, H.Q. and Panaccione, R. and Steinhart, A.H. and Cino, M. and Mack, D. and Marshall, J. and Ropeleski, M. and Bitton, A. and Jacobson, K. and McGrath, J. and Yerushalmi, B. and Abreu, M.T. and Bernstein, C.N. and Radford-Smith, G. and Lees, C. and Turner, D. and Madsen, K. and Guttman, D.S. and Silverberg, M. and Moayyedi, P. and Beck, P. and Dieleman, L. and Feagan, B.G. and Kaplan, G. and Krause, D.O. and Seidman, E. and Snapper, S. and Stadnyk, A. and Surette, M. and Walters, T. and Vallance, B. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Hyams, J. and Otley, A. and Hedin, C. and Hussey, S. and Keljo, D. and Kevans, D. and Murthy, S. and Parekh, N. and Plamondon, S. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C.

MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohns disease

Jci Insight

Layunta, E. and J{\"a}verfelt, S. and van de Koolwijk, F.C. and Sivertsson, M. and Dolan, B. and Arike, L. and Thulin, S.I.M. and Vallance, B.A. and Pelaseyed, T.

Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus

Gut Microbes

Chen, Y. and Gilliland, A. and Liang, Q. and Han, X. and Yang, H. and Chan, J. and L{\'e}vesque, D. and Moon, K.-M. and Daneshgar, P. and Boisvert, F.-M. and Foster, L. and Zandberg, W.F. and Bergstrom, K. and Yu, H.B. and Vallance, B.A.

The growth and pathogenesis of Citrobacter rodentium is compromised by disrupted mucin sugar pathways that accumulate N-acetylglucosamine 6-phosphate

Biorxiv

Huang, Z.C. and Mslati, M.A. and Ma, C. and Yang, H. and Liang, Q. and Crowley, S. and Dyer, R. and Ng, I. and Yu, H. and Vallance, B.A.

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis

Immunity

Hiroki, C.H. and Hassanabad, M.F. and Defaye, M. and Sarden, N. and Bartlett, A. and Farias, R. and Nguyen, A.P. and Guerrero-Fonseca, I.M. and Yoon, G. and Brown, L. and Ma, C. and Yang, H. and Belke, D. and Hassanabad, A.F. and McCoy, C. and Rosin, N.L. and Orton, D.J. and Fedak, P.W.M. and Vallance, B.A. and Yu, H. and Jacobson, K. and Khan, N. and Altier, C. and Kelly, M.M. and Yipp, B.G.

Environmental Factors Associated With Risk of Crohn's Disease Development in the Crohn's and Colitis Canada - Genetic, Environmental, Microbial Project

Clinical Gastroenterology and Hepatology

Xue, M. and Leibovitzh, H. and Jingcheng, S. and Neustaeter, A. and Dong, M. and Xu, W. and Espin-Garcia, O. and Griffiths, A.M. and Steinhart, A.H. and Turner, D. and Huynh, H.Q. and Dieleman, L.A. and Panaccione, R. and Aumais, G. and Bressler, B. and Bitton, A. and Murthy, S. and Marshall, J.K. and Hyams, J.S. and Otley, A. and Bernstein, C.N. and Moayyedi, P. and El-Matary, W. and Fich, A. and Denson, L.A. and Ropeleski, M.J. and Abreu, M.T. and Deslandres, C. and Cino, M. and Avni-Biron, I. and Lee, S.-H. and Turpin, W. and Abreu, M. and Beck, P. and Bernstein, C. and Croitoru, K. and Feagan, B. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Walters, T. and Vallance, B. and Critch, J. and Denson, L. and Herfarth, H. and Higgins, P. and Huynh, H. and Mack, D. and McGrath, J. and Panancionne, R.

Understanding Predictors of Crohn's Disease: Determinants of Altered Barrier Function in Pre-Disease Phase of Crohn's Disease

Journal of the Canadian Association of Gastroenterology

Neustaeter, A. and Leibovitzh, H. and Turpin, W. and Croitoru, K. and Abreu, M. and Beck, P. and Bernstein, C. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Moayyedi, P. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R. and Abreu, M. and Baldassano, R. and Griffiths, A.M. and Hedin, C. and Higgins, P. and Hussey, S. and Hyams, H. and Keljo, D. and Kevans, D. and Lees, C. and Marshall, J. and Murthy, S. and Panaccione, R. and Parekh, N. and Plamondon, S. and Radford-Smith, G. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C.

Pathobionts in Inflammatory Bowel Disease: Origins, Underlying Mechanisms, and Implications for Clinical Care

Gastroenterology

Gilliland, A. and Chan, J.J. and De Wolfe, T.J. and Yang, H. and Vallance, B.A.

Pathogenic diversificationof the gut commensal Providencia alcalifaciens via acquisition of a second type III secretion system

Infection and Immunity

Klein, J.A. and Predeus, A.V. and Greissl, A.R. and Clark-Herrera, M.M. and Cruz, E. and Cundiff, J.A. and Haeberle, A.L. and Howell, M. and Lele, A. and Robinson, D.J. and Westerman, T.L. and Wrande, M. and Wright, S.J. and Green, N.M. and Vallance, B.A. and McClelland, M. and Mejia, A. and Goodman, A.G. and Elfenbein, J.R. and Knodler, L.A.

Pathogenic diversification of the gut commensal Providencia alcalifaciens via acquisition of a second type III secretion system

bioRxiv

Klein, J.A. and Predeus, A.V. and Greissl, A.R. and Clark-Herrera, M.M. and Cruz, E. and Cundiff, J.A. and Haeberle, A.L. and Howell, M. and Lele, A. and Robinson, D.J. and Westerman, T.L. and Wrande, M. and Wright, S.J. and Green, N.M. and Vallance, B.A. and McClelland, M. and Mejia, A. and Goodman, A.G. and Elfenbein, J.R. and Knodler, L.A.

Bowel preparation-induced changes in the gut environment facilitate pathogen and pathobiont colonization

Research Square

Clayton, C. and McCallum, G. and Ng, K. and Srinivas, A. and Sie, C. and Tertigas, D. and Porter, I. and Pepin, D. and Fardeen, T. and Sinha, S. and Surette, M. and Vallance, B. and Tropini, C.

Protein quality control modulates the metabolic conservation in antibiotic tolerant Campylobacter jejuni

bioRxiv

Feng, J. and Li, S. and Hu, Y. and Stahl, M. and Ma, L. and Knuff-Janzen, K. and Wang, K. and Hua, M.Z. and Vallance, B.A. and Konkel, M.E. and Finlay, B.B. and Lu, X.

MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn's disease

bioRxiv

Layunta, E. and Jverfelt, S. and van de Koolwijk, F.C. and Sivertsson, M. and Dolan, B. and Arike, L. and Thulin, S. and Vallance, B.A. and Pelaseyed, T.

YK2 inhibi.on enhances Treg differen.a.on and func.on while preven.ng Th1 and Th17 differen.a.on

Biorxiv

Tuomela, K. and Garcia, R.V. and Boardman, D.A. and Tavakoli, P. and Ancheta-Schmit, M. and Sham, H.P. and Cheng, L. and Struthers, M. and Bressler, B. and Vallance, B.A. and Zhao, Q. and Levings, M.K.

In mouse and in vitro models, bowel preparation promotes pathogen colonization, translocation and exacerbation of inflammation

Biorxiv

Clayton, C.A. and Porter, I. and Deng, B.D. and McCallum, G. and Srinivas, A. and Sie, C. and He, J.Y. and Pei, A. and Tertigas, D. and Pepin, D.M. and Fardeen, T. and Ng, K.M. and Sinha, S.R. and Surette, M.G. and Vallance, B.A. and Tropini, C.

Response from the Canadian Children Inflammatory Bowel Disease Network to the US Food and Drug Administration Draft Guidance for Industry on pediatric inflammatory bowel disease: developing drugs for treatment

Journal of the Canadian Association of Gastroenterology

Wine, E. and Debruyn, J. and Crowley, E. and Griffiths, A.M. and Jeong, J. and Jacobson, K. and Lawrence, S. and Piper, H. and Smyth, M. and Tropini, C. and Vallance, B. and de Bruyn, J. and Huynh, H. and Carroll, M. and Isaac, D.M. and Armstrong, H. and El-Matary, W. and Grover, Z. and Bax, K. and Brill, H. and Dowhaniuk, J. and Prowse, K. and Sherlock, M. and Zachos, M. and Hart, L. and Popalis, C. and Griffths, A.M. and Muise, A. and Ricciuto, A. and Benchimol, E. and Jones, N. and Carman, N. and Church, P. and Walters, T. and Mulder, D. and Mack, D. and Stanisz, J. and Stintzi, A. and Pai, N. and Deslandres, C. and Breton, J. and Grzywacz, K. and Jantchou, P. and Chapuy, L. and Schneider, R. and Otley, A. and Burnett, D. and Critch, J. and Dinn, S.

Inflammasome activation links enteric Salmonella Typhimurium infection to a rapid, cytokine-dependent increase in intestinal mucin release

Gut Microbes

Han, X. and Allaire, J.M. and Crowley, S.M. and Chan, J.J. and Lau, K. and Zhang, C. and Hirota, S.A. and Bergstrom, K. and Knodler, L.A. and Vallance, B.A.

Outcomes Following Acute Severe Colitis at Initial Presentation: A Multi-centre, Prospective, Paediatric Cohort Study

Journal of Crohn's and Colitis

Dhaliwal, J. and Tertigas, D. and Carman, N. and Lawrence, S. and Debruyn, J.C. and Wine, E. and Church, P.C. and Huynh, H.Q. and Rashid, M. and El-Matary, W. and Deslandres, C. and Critch, J. and Ricciuto, A. and Carroll, M.W. and Benchimol, E.I. and Muise, A. and Jacobson, K. and Otley, A.R. and Vallance, B. and Mack, D.R. and Walters, T.D. and Surette, M.G. and Griffiths, A.M.

Turicibacterales protect mice from severeCitrobacter rodentiuminfection

Kristen L. Hoek and Kathleen G. McClanahan and Yvonne L. Latour and Nicolas Shealy and M. Blanca Piazuelo and Bruce A. Vallance and Mariana X. Byndloss and Keith T. Wilson and Danyvid Olivares-Villagmez

04 / 2023

Highly Sensitive, Flow Cytometry-Based Measurement of Intestinal Permeability in Models of Experimental Colitis

Cellular and Molecular Gastroenterology and Hepatology

Tsai, K. and Ma, C. and Han, X. and Allaire, J. and Healey, G.R. and Crowley, S.M. and Yu, H. and Jacobson, K. and Xia, L. and Priatel, J.J. and Vallance, B.A.

Sialic acid plays a pivotal role in licensing Citrobacter rodentiums transition from the intestinal lumen to a mucosal adherent niche

Proceedings of the National Academy of Sciences of the United States of America

Liang, Q. and Ma, C. and Crowley, S.M. and Allaire, J.M. and Han, X. and Chong, R.W.W. and Packer, N.H. and Yu, H.B. and Vallance, B.A.

Association between prenatal antibiotic exposure and autism spectrum disorder among term births: A population-based cohort study

Paediatric and Perinatal Epidemiology

Nitschke, A.S. and do Valle, H.A. and Vallance, B.A. and Bickford, C. and Ip, A. and Lanphear, N. and Lanphear, B. and Weikum, W. and Oberlander, T.F. and Hanley, G.E.

Anti-Integrin av6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis

Gastroenterology

Livanos, A.E. and Dunn, A. and Fischer, J. and Ungaro, R.C. and Turpin, W. and Lee, S.-H. and Rui, S. and Del Valle, D.M. and Jougon, J.J. and Martinez-Delgado, G. and Riddle, M.S. and Murray, J.A. and Laird, R.M. and Torres, J. and Agrawal, M. and Magee, J.S. and Dervieux, T. and Gnjatic, S. and Sheppard, D. and Sands, B.E. and Porter, C.K. and Croitoru, K. and Petralia, F. and Abreu, M. and Beck, P. and Bernstein, C. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Moayyedi, P. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R. and Shapiro, J. and Shah, S. and Leleiko, N.S. and Colombel, J.-F. and Mehandru, S.

Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives

Gastroenterology

Raygoza Garay, J.A. and Turpin, W. and Lee, S.-H. and Smith, M.I. and Goethel, A. and Griffiths, A.M. and Moayyedi, P. and Espin-Garcia, O. and Abreu, M. and Aumais, G.L. and Bernstein, C.N. and Biron, I.A. and Cino, M. and Deslandres, C. and Dotan, I. and El-Matary, W. and Feagan, B. and Guttman, D.S. and Huynh, H. and Dieleman, L.A. and Hyams, J.S. and Jacobson, K. and Mack, D. and Marshall, J.K. and Otley, A. and Panaccione, R. and Ropeleski, M. and Silverberg, M.S. and Steinhart, A.H. and Turner, D. and Yerushalmi, B. and Paterson, A.D. and Xu, W. and Beck, P. and Bernstein, C. and Croitoru, K. and Griffiths, A. and Guttman, D. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Critch, J. and Denson, L. and Herfarth, H. and Higgins, P. and McGrath, J. and Panancionne, R.

Autotaxin (ATX) inhibits autophagy leading to exaggerated disruption of intestinal epithelial barrier in colitis

Biochimica et Biophysica Acta - Molecular Basis of Disease

Shi, W. and Peng, K. and Yu, H. and Wang, Z. and Xia, S. and Xiao, S. and Tian, D. and Vallance, B.A. and Yu, Q.

Turicibacterales protect mice from severe Citrobacter rodentium infection

Infection and Immunity

Hoek, K.L. and McClanahan, K.G. and Latour, Y.L. and Shealy, N. and Piazuelo, M.B. and Vallance, B.A. and Byndloss, M.X. and Wilson, K.T. and Olivares-Villagmez, D.

ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions

Experimental and Molecular Medicine

Jeong, H. and Hong, E.-H. and Ahn, J.-H. and Cho, J. and Jeong, J.-H. and Kim, C.-W. and Yoon, B.-I. and Koo, J.H. and Park, Y.-Y. and Yang, Y.M. and Iwawaki, T. and Vallance, B.A. and Chang, S.-Y. and Ko, H.-J.

Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction

Gut Microbes

Scheithauer, T.P.M. and Herrema, H. and Yu, H. and Bakker, G.J. and Winkelmeijer, M. and Soukhatcheva, G. and Dai, D. and Ma, C. and Havik, S.R. and Balvers, M. and Davids, M. and Meijnikman, A.S. and Aydin, {\"O}. and van den Born, B.-J.H. and Besselink, M.G. and Busch, O.R. and de Brauw, M. and van de Laar, A. and Belzer, C. and Stahl, M. and de Vos, W.M. and Vallance, B.A. and Nieuwdorp, M. and Verchere, C.B. and van Raalte, D.H.

Autism Risk and Perinatal Antibiotic Use

Pediatrics

Nitschke, A.S. and Karim, J.L. and Vallance, B.A. and Bickford, C. and Ip, A. and Lanphear, N. and Lanphear, B. and Weikum, W. and Oberlander, T.F. and Hanley, G.E.

Application of the Eosinophilic Esophagitis Histology Scoring System Grade Scores in Patients at British Columbia Childrens Hospital

Fetal and Pediatric Pathology

Cruz, J. and Irvine, M.A. and Avinashi, V. and Chan, E.S. and Vallance, B.A. and Soller, L. and Bush, J.W.

Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination

Gut

Healey, G.R. and Golding, L. and Schick, A. and Majdoubi, A. and Lavoie, P.M. and Vallance, B.A.

A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts

Immunity

Zindl, C.L. and Witte, S.J. and Laufer, V.A. and Gao, M. and Yue, Z. and Janowski, K.M. and Cai, B. and Frey, B.F. and Silberger, D.J. and Harbour, S.N. and Singer, J.R. and Turner, H. and Lund, F.E. and Vallance, B.A. and Rosenberg, A.F. and Schoeb, T.R. and Chen, J.Y. and Hatton, R.D. and Weaver, C.T.

Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation

Gastroenterology

Turpin, W. and Dong, M. and Sasson, G. and Raygoza Garay, J.A. and Espin-Garcia, O. and Lee, S.-H. and Neustaeter, A. and Smith, M.I. and Leibovitzh, H. and Guttman, D.S. and Goethel, A. and Griffiths, A.M. and Huynh, H.Q. and Dieleman, L.A. and Panaccione, R. and Steinhart, A.H. and Silverberg, M.S. and Aumais, G. and Jacobson, K. and Mack, D. and Murthy, S.K. and Marshall, J.K. and Bernstein, C.N. and Abreu, M.T. and Moayyedi, P. and Paterson, A.D. and Abreu, M. and Beck, P. and Bernstein, C. and Croitoru, K. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and McGrath, J. and Otley, A. and Panancionne, R. and Baldassano, R. and Hedin, C. and Hussey, S. and Hyams, H. and Keljo, D. and Kevans, D. and Lees, C. and Murthy, S. and Parekh, N. and Plamondon, S. and Radford-Smith, G. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C. and Xu, W.

Variability in mRNA SARS-CoV-2 BNT162b2 vaccine immunogenicity is associated with differences in the gut microbiome and habitual dietary fibre intake

medRxiv

Healey, G.R. and Golding, L. and Schick, A. and Majdoubi, A. and Lavoie, P.M. and Vallance, B.A.

Whats for dinner? How Citrobacter rodentiums metabolism helps it thrive in the competitive gut

Current Opinion in Microbiology

Qiaochu Liang and Bruce A Vallance

10 / 2021

AN INULIN-TYPE FRUCTAN ENRICHED EXCLUSIVE ENTERAL NUTRITION FORMULA SUPPRESSES COLITIS THROUGH GUT MICROBIOME MODULATION AND PROMOTING EXPANSION OF ANTI-INFLAMMATORY T CELL SUBSETS

Genelle R. Healey and Kevin Tsai and Daniel J. Lisko and Laura Cook and Bruce A. Vallance and Kevan Jacobson

02 / 2021

Commensal bacterial-derived retinoic acid primes host defense to intestinal infection

bioRxiv

Woo, V. and Eshleman, E.M. and Whitt, J. and Hashimoto-Hill, S. and Wu, S.-E. and Engleman, L. and Rice, T. and Karns, R. and Vallance, B.A. and Alenghat, T.

Harnessing Big Data to Optimize an Algorithm for Rapid Diagnosis of Pulmonary Tuberculosis in a Real-World Setting

Frontiers in Cellular and Infection Microbiology

Peng, J. and Song, J. and Wang, F. and Zuo, P. and Lu, Y. and Liu, W. and Tian, L. and Chen, Z. and Zhu, Y. and Wang, X. and Shen, N. and Wang, X. and Wu, S. and Yu, Q. and Vallance, B.A. and Jacobson, K. and Sun, Z. and Yu, H.B.

Serum Zonulin Measured by Commercial Kit Fails to Correlate With Physiologic Measures of Altered Gut Permeability in First Degree Relatives of Crohn's Disease Patients

Frontiers in Physiology

Power, N. and Turpin, W. and Espin-Garcia, O. and Smith, M.I. and Croitoru, K. and Abreu, M. and Beck, P. and Bernstein, C. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Moayyedi, P. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R.

Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection

Cell Host and Microbe

Woo, V. and Eshleman, E.M. and Hashimoto-Hill, S. and Whitt, J. and Wu, S.-E. and Engleman, L. and Rice, T. and Karns, R. and Qualls, J.E. and Haslam, D.B. and Vallance, B.A. and Alenghat, T.

Vasoactive intestinal peptide promotes host defense against enteric pathogens by modulating the recruitment of group 3 innate lymphoid cells

Proceedings of the National Academy of Sciences of the United States of America

Yu, H.B. and Yang, H. and Allaire, J.M. and Ma, C. and Graef, F.A. and Mortha, A. and Liang, Q. and Bosman, E.S. and Reid, G.S. and Waschek, J.A. and Osborne, L.C. and Sokol, H. and Vallance, B.A. and Jacobson, K.

Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis

International Journal of Infectious Diseases

Tsankov, B.K. and Allaire, J.M. and Irvine, M.A. and Lopez, A.A. and Sauv, L.J. and Vallance, B.A. and Jacobson, K.

Creating a More Perfect Union: Modeling Intestinal Bacteria-Epithelial Interactions Using Organoids

Cellular and Molecular Gastroenterology and Hepatology

Han, X. and Mslati, M.A. and Davies, E. and Chen, Y. and Allaire, J.M. and Vallance, B.A.

Successful treatment of a kidney transplant patient with COVID-19 and late-onset Pneumocystis jirovecii pneumonia

Annals of Clinical Microbiology and Antimicrobials

Peng, J. and Ni, M. and Du, D. and Lu, Y. and Song, J. and Liu, W. and Shen, N. and Wang, X. and Zhu, Y. and Vallance, B.A. and Sun, Z. and Yu, H.B.

Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis

Gastroenterology

Galipeau, H.J. and Caminero, A. and Turpin, W. and Bermudez-Brito, M. and Santiago, A. and Libertucci, J. and Constante, M. and Raygoza Garay, J.A. and Rueda, G. and Armstrong, S. and Clarizio, A. and Smith, M.I. and Surette, M.G. and Bercik, P. and Beck, P. and Bernstein, C. and Croitoru, K. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Moayyedi, P. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R. and Verdu, E.F.

Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids

Scientific Reports

Allaire, J.M. and Poon, A. and Crowley, S.M. and Han, X. and Sharafian, Z. and Moore, N. and Stahl, M. and Bressler, B. and Lavoie, P.M. and Jacobson, K. and Li, X. and Vallance, B.A.

Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection

PLoS Pathogens

Graef, F.A. and Celiberto, L.S. and Allaire, J.M. and Kuan, M.T.Y. and Bosman, E.S. and Crowley, S.M. and Yang, H. and Chan, J.H. and Stahl, M. and Yu, H. and Quin, C. and Gibson, D.L. and Verdu, E.F. and Jacobson, K. and Vallance, B.A.

Prebiotic Enriched Exclusive Enteral Nutrition Suppresses Colitis via Gut Microbiome Modulation and Expansion of Anti-inflammatory T Cells in a Mouse Model of Colitis

Cellular and Molecular Gastroenterology and Hepatology

Healey, G.R. and Tsai, K. and Schick, A. and Lisko, D.J. and Cook, L. and Vallance, B.A. and Jacobson, K.

Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection

PLoS Pathogens

Parmar, N. and Burrows, K. and Vornewald, P.M. and Lindholm, H.T. and Zwiggelaar, R.T. and Dez-Snchez, A. and Martn-Alonso, M. and Fosslie, M. and Vallance, B.A. and Dahl, J.A. and Zaph, C. and Oudhoff, M.J.

Intestinal-epithelial LSD1 controls cytoskeletal-mediated cell identity including goblet cell effector responses required for gut inflammatory and infectious diseases

Parmar N and Burrows K and Lindholm HT and Zwiggelaar RT and Martn-Alonso M and Fosslie M and Vallance B and Dahl JA and Zaph C and Oudhoff MJ

07 / 2020

A12 SKIN EXPOSURE TO NARROW BAND UVB LIGHT MODULATES THE HUMAN INTESTINAL MICROBIOME.

Journal of the Canadian Association of Gastroenterology

Bosman ES and Albert AY and Dutz JP and Vallance B

02 / 2020

A52 BUTYRATE SUPPLEMENTATION AMELIORATES DAMAGE CAUSED BY ENTERIC CITROBACTER RODENTIUM INFECTION.

Journal of the Canadian Association of Gastroenterology

Celiberto LS and Healey G and Xu J and Xia L and Vallance B

02 / 2020

A202 DYSREGULATED ENDOPLASMIC RETICULUM STRESS PATHWAYS IN COLON-DERIVED ENTEROIDS FROM INFLAMMATORY BOWEL DISEASE PATIENTS DRIVE DC MATURATION LEADING TO A PRO-INFLAMMATORY PHENOTYPE.

Journal of the Canadian Association of Gastroenterology

Rees WD and Stahl M and Jacobson K and Bressler B and Sly LM and Vallance B and Steiner T

02 / 2020

A46 THE INFLAMMATORY CASPASES COORDINATE MUCOSAL RESTRICTION OF SALMONELLA THROUGH THE EPITHELIAL-INTRINSIC INFLAMMASOME AND IL-22 DRIVEN MUCIN SECRETION.

Journal of the Canadian Association of Gastroenterology

Crowley SM and Allaire JM and Han X and Graef FA and Stahl M and Knodler L and Vallance B

02 / 2020

A18 BUILDING BETTER ENTEROIDS: A NOVEL STRATEGY FOR ENRICHING SECRETORY EPITHELIAL CELL SUBTYPES.

Journal of the Canadian Association of Gastroenterology

Davies EE and Crowley SM and Tsai K and Diaz Gomez M and Han X and Vallance B

02 / 2020

A51 UTILIZING MUCIN-DERIVED SUGARS CONFERS A FITNESS ADVANTAGE TO THE ENTERIC PATHOGEN CITROBACTER RODENTIUM THAT PROMOTES INTESTINAL COLONIZATION.

Journal of the Canadian Association of Gastroenterology

Mslati M and Liang Q and Yu H and Ma C and Vallance B

02 / 2020

A44 NOVEL AND HIGHLY SENSITIVE FLOW CYTOMETRIC BASED METHOD FOR CONTINUOUS TRACKING OF INTESTINAL PERMEABILTIY.

Journal of the Canadian Association of Gastroenterology

Tsai K and Ma C and Crowley SM and Priatel J and Vallance B

02 / 2020

Cutting edge: Intestinal mucus limits the clonal deletion of developing T cells specific for an oral antigen

Journal of Immunology

Tsai, K. and Huang, Y.-H. and Ma, C. and Baldwin, T.A. and Harder, K.W. and Vallance, B.A. and Priatel, J.J.

Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease

Gastroenterology

Turpin, W. and Lee, S.-H. and Raygoza Garay, J.A. and Madsen, K.L. and Meddings, J.B. and Bedrani, L. and Power, N. and Espin-Garcia, O. and Xu, W. and Smith, M.I. and Griffiths, A.M. and Moayyedi, P. and Turner, D. and Seidman, E.G. and Steinhart, A.H. and Marshall, J.K. and Jacobson, K. and Mack, D. and Huynh, H. and Bernstein, C.N. and Paterson, A.D. and Abreu, M. and Beck, P. and Bernstein, C. and Croitoru, K. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Hyams, J. and McGrath, J. and Otley, A. and Panancionne, R. and Baldassano, R. and Hedin, C. and Hussey, S. and Hyams, H. and Keljo, D. and Kevans, D. and Lees, C. and Murthy, S. and Panaccione, R. and Parekh, N. and Plamondon, S. and Radford-Smith, G. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C.

Giardia spp. promote the production of antimicrobial peptides and attenuate disease severity induced by attaching and effacing enteropathogens via the induction of the NLRP3 inflammasome

International Journal for Parasitology

Manko-Prykhoda, A. and Allain, T. and Motta, J.-P. and Cotton, J.A. and Feener, T. and Oyeyemi, A. and Bindra, S. and Vallance, B.A. and Wallace, J.L. and Beck, P. and Buret, A.G.

Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohns disease subjects

BMC Medical Genetics

Turpin, W. and Bedrani, L. and Espin-Garcia, O. and Xu, W. and Silverberg, M.S. and Smith, M.I. and Garay, J.A.R. and Lee, S.-H. and Guttman, D.S. and Griffiths, A. and Moayyedi, P. and Panaccione, R. and Huynh, H. and Steinhart, H.A. and Aumais, G. and Dieleman, L.A. and Turner, D. and Abreu, M. and Beck, P. and Bernstein, C. and Croitoru, K. and Feagan, B. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Seidman, E. and Silverberg, M. and Stadnyk, A. and Steinhart, A.H. and Surette, M. and Walters, T. and Vallance, B. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R. and Baldassano, R. and Griffiths, A.M. and Hedin, C. and Hussey, S. and Hyams, H. and Keljo, D. and Kevans, D. and Lees, C. and Murthy, S. and Parekh, N. and Plamondon, S. and Radford-Smith, G. and Ropeleski, M. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C. and Snapper, S. and Paterson, A.D. and Croitoru, K.

Salmonella enterica infection of murine and human enteroid-derived monolayers elicits differential activation of epithelium-intrinsic inflammasomes

Infection and Immunity

Holly, M.K. and Han, X. and Zhao, E.J. and Crowley, S.M. and Allaire, J.M. and Knodler, L.A. and Vallance, B.A. and Smith, J.G.

Enteroids derived from inflammatory bowel disease patients display dysregulated endoplasmic reticulum stress pathways, leading to differential inflammatory responses and dendritic cell maturation

Journal of Crohn's and Colitis

Rees, W.D. and Stahl, M. and Jacobson, K. and Bressler, B. and Sly, L.M. and Vallance, B.A. and Steiner, T.S.

Direct Clinical Evidence Recommending the Use of Proteinase K or Dithiothreitol to Pretreat Sputum for Detection of SARS-CoV-2

Frontiers in Medicine

Peng, J. and Lu, Y. and Song, J. and Vallance, B.A. and Jacobson, K. and Yu, H.B. and Sun, Z.

Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes

PLoS Pathogens

Crowley, S.M. and Han, X. and Allaire, J.M. and Stahl, M. and Rauch, I. and Knodler, L.A. and Vallance, B.A.

Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

Frontiers in Immunology

Scheithauer, T.P.M. and Rampanelli, E. and Nieuwdorp, M. and Vallance, B.A. and Verchere, C.B. and van Raalte, D.H. and Herrema, H.

Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium-induced acute colitis

Journal of Molecular Medicine

Wang, Z. and Shi, W. and Tian, D. and Qin, H. and Vallance, B.A. and Yang, H. and Yu, H.B. and Yu, Q.

Poor Correlation of Oral Swabs with Esophageal Eosinophil Counts

Dysphagia

Avinashi, V. and Chan, J.M. and Bush, J.W. and Vallance, B.A. and Yang, H. and Portales-Casamar, E. and Soller, L. and Mill, C. and Chan, E.S.

Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts

Gut Microbes

Yang, H. and Mirsepasi-Lauridsen, H.C. and Struve, C. and Allaire, J.M. and Sivignon, A. and Vogl, W. and Bosman, E.S. and Ma, C. and Fotovati, A. and Reid, G.S. and Li, X. and Petersen, A.M. and Gouin, S.G. and Barnich, N. and Jacobson, K. and Yu, H.B. and Krogfelt, K.A. and Vallance, B.A.

Microbial Respiration in the Colon: Using H2O2 to Catch Your Breath

Cell Host and Microbe

Crowley, S.M. and Vallance, B.A.

Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium

PLoS Pathogens

Taylor, G.A. and Huang, H. and Fee, B.E. and Youssef, N. and Jewell, M.L. and Cantillana, V. and Schoenborn, A.A. and Rogala, A.R. and Buckley, A.F. and Feng, C.G. and Vallance, B.A. and Gulati, A.S. and Hammer, G.E.

Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease.

Inflammatory bowel diseases

Turpin W and Espin-Garcia O and Bedrani L and Madsen K and Meddings JB and Raygoza Garay JA and Silverberg MS and Smith MI and Griffiths AM and Moayyedi P and Marshall JK and Mack D and Croitoru K

10 / 2019

A11 THE INFLAMMATORY CASPASES COORDINATE MUCOSAL RESTRICTION OF THROUGH THE EPITHELIAL-INTRINSIC INFLAMMASOME.

Journal of the Canadian Association of Gastroenterology

Crowley SM and Allaire JM and Han X and Graef FA and Stahl M and Knodler L and Rauch I and Vallance B

03 / 2019

A17 THE NEUROPEPTIDE VIP REGULATES INTESTINAL IMMUNITY THROUGH MODULATING THE ACTIVATION AND RECRUITMENT OF GROUP 3 INNATE LYMPHOID CELLS.

Journal of the Canadian Association of Gastroenterology

Yu H and Yang H and Ma C and Liang Q and Bosman ES and Graef FA and Reid GS and Waschek JA and Osborne L and Vallance B and Jacobson K

03 / 2019

A156 SIALIC ACID UTILIZATION IS ESSENTIAL FOR THE IN VIVO METABOLIC FITNESS OF THE ENTERIC BACTERIAL PATHOGEN.

Journal of the Canadian Association of Gastroenterology

Liang Q and Yu H and Vallance B

03 / 2019

A41 ENDOPLASMIC RETICULUM STRESSED HUMAN COLON ORGANOIDS CONDITION DENDRITIC CELLS TO A PRO-INFLAMMATORY PHENOTYPE.

Journal of the Canadian Association of Gastroenterology

Rees WD and Steiner T and Vallance B and Stahl M and Jacobson K

03 / 2019

A37 DEFECTS IN INTESTINAL MUCUS DISRUPTS THE REPERTOIRE OF DEVELOPING T CELLS IN THE THYMUS.

Journal of the Canadian Association of Gastroenterology

Tsai K and Huang Y and Ma C and Vallance B and Priatel J

03 / 2019

A9 IL37 SIGNALING THROUGH SIGIRR: A NOVEL APPROACH TO SUPPRESS INTESTINAL INFLAMMATION.

Journal of the Canadian Association of Gastroenterology

Allaire JM and Crowley SM and Han X and Poon A and Vallance B

03 / 2019

A153 EPITHELIAL-INTRINSIC INFLAMMASOME SIGNALING REVEALED USING SEROVAR TYPHIMURIUM INFECTION OF ENTEROID DERIVED MONOLAYERS.

Journal of the Canadian Association of Gastroenterology

Han X and Crowley SM and Allaire JM and Stahl M and Knodler L and Vallance B

03 / 2019

Microbiota inhibit epithelial pathogen adherence by epigenetically regulating C-type lectin expression

Frontiers in Immunology

Woo, V. and Eshleman, E.M. and Rice, T. and Whitt, J. and Vallance, B.A. and Alenghat, T.

Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells

Gastroenterology

Cook, L. and Stahl, M. and Han, X. and Nazli, A. and MacDonald, K.N. and Wong, M.Q. and Tsai, K. and Dizzell, S. and Jacobson, K. and Bressler, B. and Kaushic, C. and Vallance, B.A. and Steiner, T.S. and Levings, M.K.

IB facilitates protective immunity against Salmonella infection via Th1 differentiation and IgG production

Scientific Reports

Ahn, J.-H. and Cho, J. and Kwon, B.-E. and Lee, G.-S. and Yoon, S.-I. and Kang, S.G. and Kim, P.-H. and Kweon, M.-N. and Yang, H. and Vallance, B.A. and Kim, Y.-I. and Chang, S.-Y. and Ko, H.-J.

Erratum: The Intestinal Epithelium: Central Coordinator of Mucosal Immunity (Trends in Immunology (2018) 39(9) (677"696), (S1471490618300681), (10.1016/j.it.2018.04.002))

Trends in Immunology

Allaire, J.M. and Crowley, S.M. and Law, H.T. and Chang, S.-Y. and Ko, H.-J. and Vallance, B.A.

Long-term effects of early-life antibiotic exposure on resistance to subsequent bacterial infection

mBio

Roubaud-Baudron, C. and Ruiz, V.E. and Swan, A.M. and Vallance, B.A. and Ozkul, C. and Pei, Z. and Li, J. and Battaglia, T.W. and Perez-Perez, G.I. and Blaser, M.J.

IL-22 preserves gut epithelial integrity and promotes disease remission during chronic Salmonella infection

Journal of Immunology

Lo, B.C. and Shin, S.B. and Hernaez, D.C. and Refaeli, I. and Yu, H.B. and Goebeler, V. and Cait, A. and Mohn, W.W. and Vallance, B.A. and McNagny, K.M.

A novel mouse model of enteric vibrio parahaemolyticus infection reveals that the type iii secretion system 2 effector vopc plays a key role in tissue invasion and gastroenteritis

mBio

Yang, H. and Santos, M.S. and Lee, J. and Law, H.T. and Chimalapati, S. and Verdu, E.F. and Vallance, B.A. and Orth, K.

Bacterial AB 5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates

Nature Communications

Patry, R.T. and Stahl, M. and Perez-Munoz, M.E. and Nothaft, H. and Wenzel, C.Q. and Sacher, J.C. and Coros, C. and Walter, J. and Vallance, B.A. and Szymanski, C.M.

Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria

Journal of Experimental Medicine

Melo-Gonzalez, F. and Kammoun, H. and Evren, E. and Dutton, E.E. and Papadopoulou, M. and Bradford, B.M. and Tanes, C. and Fardus-Reid, F. and Swann, J.R. and Bittinger, K. and Mabbott, N.A. and Vallance, B.A. and Willinger, T. and Withers, D.R. and Hepworth, M.R.

Macrophage 2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

Cell Reports

Wang, B. and Lim, J.-H. and Kajikawa, T. and Li, X. and Vallance, B.A. and Moutsopoulos, N.M. and Chavakis, T. and Hajishengallis, G.

EspF is crucial for citrobacter rodentium-induced tight junction disruption and lethality in immunocompromised animals

PLoS Pathogens

Xia, X. and Liu, Y. and Hodgson, A. and Xu, D. and Guo, W. and Yu, H. and She, W. and Zhou, C. and Lan, L. and Fu, K. and Vallance, B.A. and Wan, F.

Escherichia coli pathobionts associated with inflammatory bowel disease

Clinical Microbiology Reviews

Mirsepasi-Lauridsen, H.C. and Vallance, B.A. and Krogfelt, K.A. and Petersen, A.M.

TLR9 limits enteric antimicrobial responses and promotes microbiota-based colonisation resistance during Citrobacter rodentium infection

Cellular Microbiology

Yang, H. and Yu, H.B. and Bhinder, G. and Ryz, N.R. and Lee, J. and Yang, H. and Fotovati, A. and Gibson, D.L. and Turvey, S.E. and Reid, G.S. and Vallance, B.A.

Skin exposure to narrow band ultraviolet (Uvb) light modulates the human intestinal microbiome

Frontiers in Microbiology

Bosman, E.S. and Albert, A.Y. and Lui, H. and Dutz, J.P. and Vallance, B.A.

A295 FUCOSE AVAILABILITY AND ITS UTILIZATION IMPACT ENTERIC PATHOGEN VIRULENCE.

Journal of the Canadian Association of Gastroenterology

Allaire JM and Bhullar K and Crowley SM and Stahl M and Yang H and Verdu E and YU H and Vallance B

02 / 2018

A292 NLRP -DEPENDENT PRODUCTION OF ANTIMICROBIAL PEPTIDES DURING CO-INFECTION WITH AND.

Journal of the Canadian Association of Gastroenterology

Manko A and Motta J and Cotton J and Oyeyemi A and Vallance B and Wallace JL and Buret A

02 / 2018

A10 AN ULCERATIVE COLITIS ESCHERICHIA COLI PATHOBIONT COLONIZES THE INTESTINAL MUCOSA OF SUSCEPTIBLE HOSTS AND PROMOTES COLITIS VIA HEMOLYSIN PRODUCTION.

Journal of the Canadian Association of Gastroenterology

Yang H and Mirsepasi-Lauridsen HC and Bosman ES and Struve C and Yu H and Wu X and Ma C and Reid G and Li X and Petersen AM and Jacobson K and Krogfelt KA and Vallance B

02 / 2018

A98 VASOACTIVE INTESTINAL PEPTIDE PROMOTES TH17 IMMUNE RESPONSES THEREBY PROTECTING AGAINST CITROBACTER RODENTIUM INDUCED COLITIS.

Journal of the Canadian Association of Gastroenterology

YU H and Wu X and Yang H and Celiberto LS and Graef FA and Bosman ES and Ma C and Huang T and Reid G and Vallance B and Jacobson K

02 / 2018

A274 GUT MICROBIOTA REGULATES INNATE EPITHELIAL RESPONSES AGAINST AN ENTERIC BACTERIAL PATHOGEN.

Journal of the Canadian Association of Gastroenterology

Allaire JM and Yang H and Moore N and Crowley SM and Verdu E and Vallance B

02 / 2018

A14 INFLAMMASOME ACTIVATION COORDINATES INTESTINAL MUCOSAL DEFENSE AGAINST THE ENTERIC BACTERIAL PATHOGEN SEROVAR TYPHIMURIUM.

Journal of the Canadian Association of Gastroenterology

Crowley SM and Graef FA and Allaire JM and Knodler LA and Vallance B

02 / 2018

A107 TOLL LIKE RECEPTOR 9 LIMITS INTESTINAL INFLAMMATION AND PROMOTES MICROBIOTA BASED COLONIZATION RESISTANCE DURING CITROBACTER RODENTIUM INFECTION.

Journal of the Canadian Association of Gastroenterology

Yang H and Yu H and Bhinder G and Ryz NR and Yang H and Fotovati A and Gibson DL and Turvey SE and Reid G and Vallance B

02 / 2018

A10 CORE-1 DERIVED -GLYCOSYLATION OF THE MUCIN MUC2 PLAYS A KEY ROLE IN HOST DEFENSE AGAINST ENTERIC INFECTION.

Journal of the Canadian Association of Gastroenterology

Celiberto LS and Chan JY and Law HT and Bhullar K and Xia L and Cavallini DC and Vallance B

02 / 2018

A277 THE FIRST LINE OF DEFENSE: THE ROLE OF EPITHELIAL CELL INFLAMMASOMES IN CONTROLLING INFECTION.

Journal of the Canadian Association of Gastroenterology

Stahl M and Hoang T and Knodler LA and Vallance B

02 / 2018

Report on the Canadian Association of Gastroenterology Visiting Research Professorship and Visiting Clinical Professorship.

Journal of the Canadian Association of Gastroenterology

Vallance B and Waschke K

02 / 2018

A8 PROLONGED FASTING ALTERS THE GUT MICROBIOME AND PROTECTS AGAINST -INDUCED GUT INFLAMMATION.

Journal of the Canadian Association of Gastroenterology

Graef FA and Lau J and Bosman ES and Kuan M and Yang H and Celiberto LS and Berkmann JC and Stahl M and Crowley SM and Yu H and Surette M and Verdu E and Jacobson K and Vallance B

02 / 2018

Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis

Frontiers in immunology

Sham, H.P. and Bazett, M. and Bosiljcic, M. and Yang, H. and Luk, B. and Law, H.T. and Morampudi, V. and Yu, H.B. and Pankovich, J. and Sutcliffe, S. and Bressler, B. and Marshall, J.K. and Fedorak, R.N. and Chen, J. and Jones, M. and Gunn, H. and Kalyan, S. and Vallance, B.A.

Pediatric eosinophilic esophagitis is associated with increased lamina propria immunoglobulin g4-positive plasma cells

Journal of Pediatric Gastroenterology and Nutrition

Mohammad, N. and Avinashi, V. and Chan, E. and Vallance, B.A. and Portales-Casamar, E. and Bush, J.W.

Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome

Immunology

Celiberto, L.S. and Graef, F.A. and Healey, G.R. and Bosman, E.S. and Jacobson, K. and Sly, L.M. and Vallance, B.A.

The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

Trends in Immunology

Allaire, J.M. and Crowley, S.M. and Law, H.T. and Chang, S.-Y. and Ko, H.-J. and Vallance, B.A.

Genetic ablation of cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition

American Journal of Physiology - Endocrinology and Metabolism

Patankar, J.V. and Wong, C.K. and Morampudi, V. and Gibson, W.T. and Vallance, B. and Ioannou, G.N. and Hayden, M.R.

First-reported pediatric cases of American ginseng anaphylaxis and allergy

Allergy, Asthma and Clinical Immunology

Erdle, S.C. and Chan, E.S. and Yang, H. and Vallance, B.A. and Mill, C. and Wong, T.

Frontline defenders: Goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease

American Journal of Physiology - Gastrointestinal and Liver Physiology

Allaire, J.M. and Morampudi, V. and Crowley, S.M. and Stahl, M. and Yu, H. and Bhullar, K. and Knodler, L.A. and Bressler, B. and Jacobson, K. and Vallance, B.A.

Isolation and characterization of potentially probiotic bacterial strains from mice: proof of concept for personalized probiotics

Nutrients

Celiberto, L.S. and Pinto, R.A. and Rossi, E.A. and Vallance, B.A. and Cavallini, D.C.U.

The Muc2 mucin coats murine paneth cell granules and facilitates their content release and dispersion

American Journal of Physiology - Gastrointestinal and Liver Physiology

Stahl, M. and Tremblay, S. and Montero, M. and Vogl, W. and Xia, L. and Jacobson, K. and Menendez, A. and Vallance, B.A.

Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development

Scientific Reports

Bhinder, G. and Allaire, J.M. and Garcia, C. and Lau, J.T. and Chan, J.M. and Ryz, N.R. and Bosman, E.S. and Graef, F.A. and Crowley, S.M. and Celiberto, L.S. and Berkmann, J.C. and Dyer, R.A. and Jacobson, K. and Surette, M.G. and Innis, S.M. and Vallance, B.A.

Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease

PLoS ONE

Manko, A. and Motta, J.-P. and Cotton, J.A. and Feener, T. and Oyeyemi, A. and Vallance, B.A. and Wallace, J.L. and Buret, A.G.

Noncanonical inflammasomes: Antimicrobial defense that does not play by the rules

Cellular Microbiology

Crowley, S.M. and Vallance, B.A. and Knodler, L.A.

Mouse models for Campylobacter jejuni colonization and infection

Methods in Molecular Biology

Stahl, M. and Graef, F.A. and Vallance, B.A.

Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation

Cell Reports

Navabi, N. and Whitt, J. and Wu, S.-E. and Woo, V. and Moncivaiz, J. and Jordan, M.B. and Vallance, B.A. and Way, S.S. and Alenghat, T.

A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function

American Journal of Physiology - Gastrointestinal and Liver Physiology

Fernando, E.H. and Dicay, M. and Stahl, M. and Gordon, M.H. and Vegso, A. and Baggio, C. and Alston, L. and Lopes, F. and Baker, K. and Hirota, S. and McKay, D.M. and Vallance, B. and MacNaughton, W.K.

Tricellular tight junction protein tricellulin is targeted by the enteropathogenic Escherichia coli effector EspG1, leading to epithelial barrier disruption

Infection and Immunity

Morampudi, V. and Graef, F.A. and Stahl, M. and Dalwadi, U. and Conlin, V.S. and Huang, T. and Vallance, B.A. and Yu, H.B. and Jacobson, K.

Campylobacter

Laboratory Models for Foodborne Infections

Stahl, M. and Vallance, B.A.

Association of host genome with intestinal microbial composition in a large healthy cohort.

Nature genetics

Turpin W and Espin-Garcia O and Xu W and Silverberg MS and Kevans D and Smith MI and Guttman DS and Griffiths A and Panaccione R and Otley A and Xu L and Shestopaloff K and Croitoru K

10 / 2016

The goblet cell-derived mediator RELM- drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis

Mucosal Immunology

Morampudi, V. and Dalwadi, U. and Bhinder, G. and Sham, H.P. and Gill, S.K. and Chan, J. and Bergstrom, K.S.B. and Huang, T. and Ma, C. and Jacobson, K. and Gibson, D.L. and Vallance, B.A.

The helical shape of Campylobacter jejuni promotes in vivo pathogenesis by aiding transit through intestinal mucus and colonization of crypts

Infection and Immunity

Stahl, M. and Frirdich, E. and Vermeulen, J. and Badayeva, Y. and Li, X. and Vallance, B.A. and Gaynor, E.C.

mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium

Scientific Reports

Lin, X. and Yang, J. and Wang, J. and Huang, H. and Wang, H.-X. and Chen, P. and Wang, S. and Pan, Y. and Qiu, Y.-R. and Taylor, G.A. and Vallance, B.A. and Gao, J. and Zhong, X.-P.

Dynamic interactions of a conserved enterotoxigenic Escherichia coli adhesin with intestinal mucins govern epithelium engagement and toxin delivery

Infection and Immunity

Kumar, P. and Kuhlmann, F.M. and Bhullar, K. and Yang, H. and Vallance, B.A. and Xia, L. and Luo, Q. and Fleckenstein, J.M.

NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis

Cell Death and Differentiation

Chung, H. and Vilaysane, A. and Lau, A. and Stahl, M. and Morampudi, V. and Bondzi-Simpson, A. and Platnich, J.M. and Bracey, N.A. and French, M.-C. and Beck, P.L. and Chun, J. and Vallance, B.A. and Muruve, D.A.

Prolonged antibiotic treatment induces a diabetogenic intestinal microbiome that accelerates diabetes in NOD mice

ISME Journal

Brown, K. and Godovannyi, A. and Ma, C. and Zhang, Y. and Ahmadi-Vand, Z. and Dai, C. and Gorzelak, M.A. and Chan, Y. and Chan, J.M. and Lochner, A. and Dutz, J.P. and Vallance, B.A. and Gibson, D.L.

Salmonella and the inflammasome: Battle for intracellular dominance

Current Topics in Microbiology and Immunology

Crowley, S.M. and Knodler, L.A. and Vallance, B.A.

Investigation of host and pathogen contributions to infectious colitis using the citrobacter rodentium mouse model of infection

Methods in Molecular Biology

Bosman, E.S. and Chan, J.M. and Bhullar, K. and Vallance, B.A.

The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria

PLoS Pathogens

Singh, K. and Al-Greene, N.T. and Verriere, T.G. and Coburn, L.A. and Asim, M. and Barry, D.P. and Allaman, M.M. and Hardbower, D.M. and Delgado, A.G. and Piazuelo, M.B. and Vallance, B.A. and Gobert, A.P. and Wilson, K.T.

Vasoactive intestinal peptide prevents PKCe-induced intestinal epithelial barrier disruption during EPEC infection

American Journal of Physiology - Gastrointestinal and Liver Physiology

Morampudi, V. and Conlin, V.S. and Dalwadi, U. and Wu, X. and Marshall, K.C. and Nguyen, C. and Vallance, B.A. and Jacobson, K.

Metalloprotease NleC Suppresses Host NF-B/Inflammatory Responses by Cleaving p65 and Interfering with the p65/RPS3 Interaction

PLoS Pathogens

Hodgson, A. and Wier, E.M. and Fu, K. and Sun, X. and Yu, H. and Zheng, W. and Sham, H.P. and Johnson, K. and Bailey, S. and Vallance, B.A. and Wan, F.

Goblet Cell Derived RELM- Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation

Plos Pathogens

Bergstrom, K.S.B. and Morampudi, V. and Chan, J.M. and Bhinder, G. and Lau, J. and Yang, H. and Ma, C. and Huang, T. and Ryz, N. and Sham, H.P. and Zarepour, M. and Zaph, C. and Artis, D. and Nair, M. and Vallance, B.A.

The serine protease autotransporter Pic modulates Citrobacter rodentium pathogenesis and its innate recognition by the host

Infection and Immunity

Bhullar, K. and Zarepour, M. and Yu, H. and Yang, H. and Croxen, M. and Stahl, M. and Finlay, B.B. and Turvey, S.E. and Vallance, B.A.

Humoral immunity in the gut selectively targets phenotypically virulent attaching-and-effacing bacteria for intraluminal elimination

Cell Host and Microbe

Kamada, N. and Sakamoto, K. and Seo, S.-U. and Zeng, M.Y. and Kim, Y.-G. and Cascalho, M. and Vallance, B.A. and Puente, J.L. and Nez, G.

Dietary vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium-induced colitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Ryz, N.R. and Lochner, A. and Bhullar, K. and Ma, C. and Huang, T. and Bhinder, G. and Bosman, E. and Wu, X. and Innis, S.M. and Jacobson, K. and Vallance, B.A.

Interleukin-1 (IL-1) signaling in intestinal stromal cells controls KC/ CXCL1 secretion, which correlates with recruitment of IL-22- secreting neutrophils at early stages of Citrobacter rodentium infection

Infection and Immunity

Lee, Y.-S. and Yang, H. and Yang, J.-Y. and Kim, Y. and Lee, S.-H. and Kim, J.H. and Jang, Y.J. and Vallance, B.A. and Kweon, M.-N.

Vasoactive intestinal polypeptide promotes intestinal barrier homeostasis and protection against colitis in mice

PLoS ONE

Wu, X. and Conlin, V.S. and Morampudi, V. and Ryz, N.R. and Nasser, Y. and Bhinder, G. and Bergstrom, K.S. and Yu, H.B. and Waterhouse, C.C.M. and Buchan, A.M.J. and Popescu, O.E. and Gibson, W.T. and Waschek, J.A. and Vallance, B.A. and Jacobson, K.

Insights into Campylobacter jejuni colonization of the mammalian intestinal tract using a novel mouse model of infection

Gut Microbes

Stahl, M. and Vallance, B.A.

Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection

PLoS Pathogens

Rausch, P. and Steck, N. and Suwandi, A. and Seidel, J.A. and Knzel, S. and Bhullar, K. and Basic, M. and Bleich, A. and Johnsen, J.M. and Vallance, B.A. and Baines, J.F. and Grassl, G.A.

Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen

PLoS Pathogens

Sit, B. and Crowley, S.M. and Bhullar, K. and Lai, C.C.-L. and Tang, C. and Hooda, Y. and Calmettes, C. and Khambati, H. and Ma, C. and Brumell, J.H. and Schryvers, A.B. and Vallance, B.A. and Moraes, T.F.

DNBS/TNBS colitis models: Providing insights into inflammatory bowel disease and effects of dietary fat

Journal of Visualized Experiments

Morampudi, V. and Bhinder, G. and Wu, X. and Dai, C. and Sham, H.P. and Vallance, B.A. and Jacobson, K.

Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions

Manthey, C.F. and Calabio, C.B. and Wosinski, A. and Hanson, E.M. and Vallance, B.A. and Groisman, A. and Martn, M.G. and Wang, J.Y.J. and Eckmann, L.

SLAM-SAP signaling promotes differentiation of IL-17-producing T cells and progression of experimental autoimmune encephalomyelitis

Journal of Immunology

Huang, Y.-H. and Tsai, K. and Ma, C. and Vallance, B.A. and Priatel, J.J. and Tan, R.

TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen

Tsuji, S. and Stein, L. and Kamada, N. and Nuez, G. and Bram, R. and Vallance, B.A. and Sousa, A.E. and Platt, J.L. and Cascalho, M.

HOW NONINVASIVE PATHOGENS INDUCE DISEASE: LESSONS FROM ENTEROPATHOGENIC AND ENTEROHEMORRHAGIC ESCHERICHIA COLI

Microbial Pathogenesis and the Intestinal Epithelial Cell

Vallance, B.A. and Chan, C. and Finlay, B.B.

A Novel Mouse Model of Campylobacter jejuni Gastroenteritis Reveals Key Pro-inflammatory and Tissue Protective Roles for Toll-like Receptor Signaling during Infection

Stahl, M. and Ries, J. and Vermeulen, J. and Yang, H. and Sham, H.P. and Crowley, S.M. and Badayeva, Y. and Turvey, S.E. and Gaynor, E.C. and Li, X. and Vallance, B.A.

Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens

Cell Host and Microbe

Knodler, L.A. and Crowley, S.M. and Sham, H.P. and Yang, H. and Wrande, M. and Ma, C. and Ernst, R.K. and Steele-Mortimer, O. and Celli, J. and Vallance, B.A.

Intestinal epithelium-specific MyD88 signaling impacts host susceptibility to infectious colitis by promoting protective goblet cell and antimicrobial responses

Bhinder, G. and Stahl, M. and Sham, H.P. and Crowley, S.M. and Morampudi, V. and Dalwadi, U. and Ma, C. and Jacobson, K. and Vallance, B.A.

The Citrobacter rodentium mouse model: studying pathogen and host contributions to infectious colitis.

Journal of visualized experiments : JoVE

Bhinder G and Sham HP and Chan JM and Morampudi V and Jacobson K and Vallance BA

02 / 2013

SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens

Sham, H.P. and Yu, E.Y.S. and Gulen, M.F. and Bhinder, G. and Stahl, M. and Chan, J.M. and Brewster, L. and Morampudi, V. and Gibson, D.L. and Hughes, M.R. and McNagny, K.M. and Li, X. and Vallance, B.A.

Requirement of epithelial integrin-linked kinase for facilitation of Citrobacter rodentium-induced colitis

Assi, K. and Bergstrom, K. and Vallance, B. and Owen, D. and Salh, B.

Bacterial stimulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal paneth cell a-defensins

Menendez, A. and Willing, B.P. and Montero, M. and Wlodarska, M. and So, C.C. and Bhinder, G. and Vallance, B.A. and Finlay, B.B.

Resistin-like molecule a promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation

Osborne, L.C. and Joyce, K.L. and Alenghat, T. and Sonnenberg, G.F. and Giacomin, P.R. and Du, Y. and Bergstrom, K.S. and Vallance, B.A. and Nair, M.G.

CD4+ T cells drive goblet cell depletion during citrobacter rodentium infection

Infection and Immunity

Chan, J.M. and Bhinder, G. and Sham, H.P. and Ryz, N. and Huang, T. and Bergstrom, K.S. and Vallance, B.A.

The mucin muc2 limits pathogen burdens and epithelial barrier dysfunction during salmonella enterica serovar typhimurium colitis

Zarepour, M. and Bhullar, K. and Montero, M. and Ma, C. and Huang, T. and Velcich, A. and Xia, L. and Vallance, B.A.

Activation of p38a in T cells regulates the intestinal host defense against attaching and effacing bacterial infections

Shim, E.-J. and Bang, B.-R. and Kang, S.-G. and Ma, J. and Otsuka, M. and Kang, J. and Stahl, M. and Han, J. and Xiao, C. and Vallance, B.A. and Kang, Y.J.

Innate host responses to enteric bacterial pathogens: A balancing act between resistance and tolerance

Bergstrom, K.S. and Sham, H.P. and Zarepour, M. and Vallance, B.A.

MyD88 signaling promotes both mucosal homeostatic and fibrotic responses during Salmonella-induced colitis

Mnsson, L.E. and Montero, M. and Zarepour, M. and Bergstrom, K.S. and Ma, C. and Huang, T. and Man, C. and Grassl, G.A. and Vallance, B.A.

Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses

American Journal of Physiology Gastrointestinal and Liver Physiology

Ryz, N.R. and Patterson, S.J. and Zhang, Y. and Ma, C. and Huang, T. and Bhinder, G. and Wu, X. and Chan, J. and Glesby, A. and Sham, H.P. and Dutz, J.P. and Levings, M.K. and Jacobson, K. and Vallance, B.A.

Regulated virulence controls the ability of a pathogen to compete with the gut microbiota

Kamada, N. and Kim, Y.-G. and Sham, H.P. and Vallance, B.A. and Puente, J.L. and Martens, E.C. and Nez, G.

Toll-Like Receptors are critical in controlling colonic inflammation and cancer.

BMC proceedings

Xiao H and Yin W and Khan MA and Gulen MF and Vallance BA and Li X

01 / 2011

Attaching and effacing bacterial effector NleC suppresses epithelial inflammatory responses by inhibiting NF-B and p38 mitogen-activated protein kinase activation

Sham, H.P. and Shames, S.R. and Croxen, M.A. and Ma, C. and Chan, J.M. and Khan, M.A. and Wickham, M.E. and Deng, W. and Finlay, B.B. and Vallance, B.A.

Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status, and ion transporter gene expression

Ghosh, S. and Dai, C. and Brown, K. and Rajendiran, E. and Makarenko, S. and Baker, J. and Ma, C. and Halder, S. and Montero, M. and Ionescu, V.A. and Klegeris, A. and Vallance, B.A. and Gibson, D.L.

Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis

Wlodarska, M. and Willing, B. and Keeney, K.M. and Menendez, A. and Bergstrom, K.S. and Gill, N. and Russell, S.L. and Vallance, B.A. and Finlay, B.B.

Citrobacter rodentium infection induces MyD88-dependent formation of ubiquitinated protein aggregates in the intestinal epithelium

Kaniuk, N.A. and Lam, G.Y. and Ma, C. and Galindo-Mata, E. and Jones, N. and Vallance, B.A. and Brumell, J.H.

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

Dupaul-Chicoine, J. and Yeretssian, G. and Doiron, K. and Bergstrom, K.S.B. and McIntire, C.R. and LeBlanc, P.M. and Meunier, C. and Turbide, C. and Gros, P. and Beauchemin, N. and Vallance, B.A. and Saleh, M.

Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice

Lee, A.S. and Gibson, D.L. and Zhang, Y. and Sham, H.P. and Vallance, B.A. and Dutz, J.P.

Epithelial p38a controls immune cell recruitment in the colonic mucosa

Kang, Y.J. and Otsuka, M. and van den Berg, A. and Hong, L. and Huang, Z. and Wu, X. and Zhang, D.-W. and Vallance, B.A. and Tobias, P.S. and Han, J.

The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling

Shames, S.R. and Deng, W. and Guttman, J.A. and de Hoog, C.L. and Li, Y. and Hardwidge, P.R. and Sham, H.P. and Vallance, B.A. and Foster, L.J. and Finlay, B.B.

Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa

Bergstrom, K.S.B. and Kissoon-Singh, V. and Gibson, D.L. and Ma, C. and Montero, M. and Sham, H.P. and Ryz, N. and Huang, T. and Velcich, A. and Finlay, B.B. and Chadee, K. and Vallance, B.A.

Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling

Gibson, D.L. and Montero, M. and Ropeleski, M.J. and Bergstrom, K.S.B. and Ma, C. and Ghosh, S. and Merkens, H. and Huang, J. and Mnsson, L.E. and Sham, H.P. and McNagny, K.M. and Vallance, B.A.

Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apcmin mice

Gastroenterology

Xiao, H. and Yin, W. and Khan, M.A. and Gulen, M.F. and Zhou, H. and Sham, H.P. and Jacobson, K. and Vallance, B.A. and Li, X.

The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells

Khan, M.A. and Steiner, T.S. and Sham, H.P. and Bergstrom, K.S. and Huang, J.T. and Assi, K. and Salh, B. and Tai, I.T. and Li, X. and Vallance, B.A.

Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia

Knodler, L.A. and Vallance, B.A. and Celli, J. and Winfree, S. and Hansen, B. and Montero, M. and Steele-Mortimer, O.

Nramp1 drives an accelerated inflammatory response during Salmonella -induced colitis in mice

Valdez, Y. and Grassl, G.A. and Guttman, J.A. and Coburn, B. and Gros, P. and Vallance, B.A. and Finlay, B.B.

Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis

Conlin, V.S. and Wu, X. and Nguyen, C. and Dai, C. and Vallance, B.A. and Buchan, A.M.J. and Boyer, L. and Jacobson, K.

Innate immunity and microbes: Conversations with the gut leading to intestinal tissue repair and fibrosis

Gibson, D.L. and Montero, M. and Ryz, N.R. and Vallance, B.A.

Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis

MacDonald, M.L.E. and Bissada, N. and Vallance, B.A. and Hayden, M.R.

Salmonella infection of gallbladder epithelial cells drives local inflammation and injury in a model of acute typhoid fever

Menendez, A. and Arena, E.T. and Guttman, J.A. and Thorson, L. and Vallance, B.A. and Vogl, W. and Finlay, B.

Aggregation via the red, dry, and rough morphotype is not a virulence adaptation in Salmonella enterica serovar typhimurium

White, A.P. and Gibson, D.L. and Grassl, G.A. and Kay, W.W. and Finlay, B.B. and Vallance, B.A. and Surette, M.G.

Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis

Gibson, D.L. and Ma, C. and Rosenberger, C.M. and Bergstrom, K.S.B. and Valdez, Y. and Huang, J.T. and Khan, M.A. and Vallance, B.A.

Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection

Valdez, Y. and Diehl, G.E. and Vallance, B.A. and Grassl, G.A. and Guttman, J.A. and Brown, N.F. and Rosenberger, C.M. and Littman, D.R. and Gros, P. and Finlay, B.B.

Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus

Ghia, J.-E. and Galeazzi, F. and Ford, D.C. and Hogaboam, C.M. and Vallance, B.A. and Collins, S.

Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen

Bergstrom, K.S.B. and Guttman, J.A. and Rumi, M. and Ma, C. and Bouzari, S. and Khan, M.A. and Gibson, D.L. and Vogl, A.W. and Vallance, B.A.

A novel secretion pathway of Salmonella enterica acts as an antivirulence modulator during salmonellosis

Gal-Mor, O. and Gibson, D.L. and Baluta, D. and Vallance, B.A. and Finlay, B.B.

Intestinal microbiota are transiently altered during Salmonella-induced gastroenteritis

Gibson, D.L. and Vallance, B.A.

Chronic Enteric Salmonella Infection in Mice Leads to Severe and Persistent Intestinal Fibrosis

Grassl, G.A. and Valdez, Y. and Bergstrom, K.S.B. and Vallance, B.A. and Finlay, B.B.

Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium

Khan, M.A. and Bouzari, S. and Ma, C. and Rosenberger, C.M. and Bergstrom, K.S.B. and Gibson, D.L. and Steiner, T.S. and Vallance, B.A.

MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacterrodentium-induced colitis

Gibson, D.L. and Ma, C. and Bergstrom, K.S.B. and Huang, J.T. and Man, C. and Vallance, B.A.

Genetic profiling of dendritic cells exposed to live- or ultraviolet-irradiated Chlamydia muridarum reveals marked differences in CXC chemokine profiles

Zaharik, M.L. and Nayar, T. and White, R. and Ma, C. and Vallance, B.A. and Straka, N. and Jiang, X. and Rey-Ladino, J. and Shen, C. and Brunham, R.C.

Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors

Wu, X. and Vallance, B.A. and Boyer, L. and Bergstrom, K.S.B. and Walker, J. and Madsen, K. and O'Kusky, J.R. and Buchan, A.M. and Jacobson, K.

The Toll-Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis

Xiao, H. and Gulen, M.F. and Qin, J. and Yao, J. and Bulek, K. and Kish, D. and Altuntas, C.Z. and Wald, D. and Ma, C. and Zhou, H. and Tuohy, V.K. and Fairchild, R.L. and de la Motte, C. and Cua, D. and Vallance, B.A. and Li, X.

IL-4 gene transfer to the small bowel serosa leads to intestinal inflammation and smooth muscle hyperresponsiveness

Vallance, B.A. and Radojevic, N. and Hogaboam, C.M. and Deng, Y. and Gauldie, J. and Collins, S.M.

The adaptor Act1 is required for interleukin 17 - Dependent signaling associated with autoimmune and inflammatory disease

Qian, Y. and Liu, C. and Hartupee, J. and Altuntas, C.Z. and Gulen, M.F. and Jane-Wit, D. and Xiao, J. and Lu, Y. and Giltiay, N. and Liu, J. and Kordula, T. and Zhang, Q.-W. and Vallance, B. and Swaidani, S. and Aronica, M. and Tuohy, V.K. and Hamilton, T. and Li, X.

Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice

Khan, M.A. and Ma, C. and Knodler, L.A. and Valdez, Y. and Rosenberger, C.M. and Deng, W. and Finlay, B.B. and Vallance, B.A.

Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat

Saunders, P.R. and Miceli, P. and Vallance, B.A. and Wang, L. and Pinto, S. and Tougas, G. and Kamath, M. and Jacobson, K.

Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: Role of mitochondrial associated protein (Map)

Ma, C. and Wickham, M.E. and Guttman, J.A. and Deng, W. and Walker, J. and Madsen, K.L. and Jacobson, K. and Vogl, W.A. and Finlay, B.B. and Vallance, B.A.

Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine

Brown, N.F. and Vallance, B.A. and Coombes, B.K. and Valdez, Y. and Coburn, B.A. and Finlay, B.B.

Myenteric plexus injury and apoptosis in experimental colitis

Boyer, L. and Ghoreishi, M. and Templeman, V. and Vallance, B.A. and Buchan, A.M. and Jevon, G. and Jacobson, K.

Salmonella enterica serovar Typhimurium pathogenicity island 2 is necessary for complete virulence in a mouse model of infectious enterocolitis

Coburn, B. and Li, Y. and Owen, D. and Vallance, B.A. and Finlay, B.B.

Modulation of host cytoskeleton function by the enteropathogenic Escherichia coli and Citrobacter rodentium effector protein EspG

Hardwidge, P.R. and Deng, W. and Vallance, B.A. and Rodriguez-Escudero, I. and Cid, V.J. and Molina, M. and Finlay, B.B.

TGF-1 gene transfer to the mouse colon leads to intestinal fibrosis

Vallance, B.A. and Gunawan, M.I. and Hewlett, B. and Bercik, P. and Van Kampen, C. and Galeazzi, F. and Sime, P.J. and Gauldie, J. and Collins, S.M.

Cloning vectors and fluorescent proteins can significantly inhibit Salmonella enterica virulence in both epithelial cells and macrophages: Implications for bacterial pathogenesis studies

Knodler, L.A. and Bestor, A. and Ma, C. and Hansen-Wester, I. and Hensel, M. and Vallance, B.A. and Steele-Mortimer, O.

SseK1 and SseK2 are novel translocated proteins of Salmonella enterica serovar Typhimurium

Kujat Choy, S.L. and Boyle, E.C. and Gal-Mor, O. and Goode, D.L. and Valdez, Y. and Vallance, B.A. and Finlay, B.B.

Toll-Like Receptor 4 Dependence of Innate and Adaptive Immunity to Salmonella: Importance of the Kupffer Cell Network

Vazquez-Torres, A. and Vallance, B.A. and Bergman, M.A. and Finlay, B.B. and Cookson, B.T. and Jones-Carson, J. and Fang, F.C.

Modeling enteropathogenic and enterohemorrhagic E. coli infections and disease

Vallance, B.A. and Khan, M.A. and Deng, W. and Gruenheid, S. and Finlay, B.B.

Relative contributions of NOS isoforms during experimental colitis: Endothelial-derived NOS maintains mucosal integrity

Vallance, B.A. and Dijkstra, G. and Qiu, B. and Van Der Waaij, L.A. and Van Goor, H. and Jansen, P.L.M. and Mashimo, H. and Collins, S.M.

Dissecting virulence: Systematic and functional analyses of a pathogenicity island

Deng, W. and Puente, J.L. and Gruenheid, S. and Li, Y. and Vallance, B.A. and Vzquez, A. and Barba, J. and Ibarra, J.A. and O'Donnell, P. and Metalnikov, P. and Ashman, K. and Lee, S. and Goode, D. and Pawson, T. and Finlay, B.B.

Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies

Maaser, C. and Housley, M.P. and Iimura, M. and Smith, J.R. and Vallance, B.A. and Finlay, B.B. and Schreiber, J.R. and Varki, N.M. and Kagnoff, M.F. and Eckmann, L.

Erratum: SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells (Traffic (2003) vol. 4 (1) (36-48))

Brumell, J.H. and Kujat-Choy, S. and Brown, N.F. and Vallance, B.A. and Knodler, L.A. and Finlay, B.B.

SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells

Coombes, B.K. and Brown, N.F. and Kujat-Choy, S. and Vallance, B.A. and Finlay, B.B.

Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium

Vallance, B.A. and Deng, W. and Jacobson, K. and Finlay, B.B.

Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice

Deng, W. and Vallance, B.A. and Li, Y. and Puente, J.L. and Finlay, B.B.

SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells

Brumell, J.H. and Kujat-Choy, S. and Brown, N.F. and Vallance, B.A. and Knodler, L.A. and Finlay, B.B.

Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes

Knodler, L.A. and Vallance, B.A. and Hensel, M. and Jckel, D. and Finlay, B.B. and Steele-Mortimer, O.

Current progress in enteropathogenic and enterohemorrhagic Escherichia coli vaccines

Horne, C. and Vallance, B.A. and Deng, W. and Finlay, B.B.

Enteropathogenic and enterohemorrhagic Escherichia coli infections: Emerging themes in pathogenesis and prevention

Vallance, B.A. and Chan, C. and Robertson, M.L. and Finlay, B.B.

Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems

Knodler, L.A. and Celli, J. and Hardt, W.-D. and Vallance, B.A. and Yip, C. and Finlay, B.B.

Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen Citrobacter rodentium in infected mice

Vallance, B.A. and Deng, W. and De Grado, M. and Chan, C. and Jacobson, K. and Finlay, B.B.

Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection

Vallance, B.A. and Deng, W. and Knodler, L.A. and Finlay, B.B.

Host-pathogen interactions: Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes

Zaharik, M.L. and Vallance, B.A. and Puente, J.L. and Gros, P. and Finlay, B.B.

Mast cell-independent impairment of host defense and muscle contraction in T. spiralis-infected W/Wv mice

American Journal of Physiology Gastrointestinal and Liver Physiology

Vallance, B.A. and Blennerhassett, P.A. and Huizinga, J.D. and Collins, S.M.

Role of immunologic factors and cyclooxygenase 2 in persistent postinfective enteric muscle dysfunction in mice

Barbara, G. and De Giorgio, R. and Deng, Y. and Vallance, B. and Blennerhassett, P. and Collins, S.M.

Critical role for signal transducer and activator of transcription factor 6 in mediating intestinal muscle hypercontractility and worm expulsion in Trichinella spiralis-infected mice

Khan, W.I. and Vallance, B.A. and Blennerhassett, P.A. and Deng, Y. and Verdu, E.F. and Matthaei, K.I. and Collins, S.M.

Neural change in Trichinella-infected mice is MHC II independent and involves M-CSF-derived macrophages

Galeazzi, F. and Lovato, P. and Blennerhassett, P.A. and Haapala, E.M. and Vallance, B.A. and Collins, S.M.

IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice

Khan, W.I. and Blennerhassett, P.A. and Deng, Y. and Gauldie, J. and Vallance, B.A. and Collins, S.M.

Locus of enterocyte effacement from Citrobacter rodentium: Sequence analysis and evidence for horizontal transfer among attaching and effacing pathogens

Deng, W. and Li, Y. and Vallance, B.A. and Finlay, B.B.

Enteropathogenic Escherichia coli infection induces expression of the early growth response factor by activating mitogen-activated protein kinase cascades in epithelial cells

De Grado, M. and Rosenberger, C.M. and Gauthier, A. and Vallance, B.A. and Finlay, B.B.

Inflammation-induced impairment of enteric nerve function in nematode- infected mice is macrophage dependent

Galeazzi, F. and Haapala, E.M. and Van Rooijen, N. and Vallance, B.A. and Collins, S.M.

Exploitation of host cells by enteropathogenic Escherichia coli

Vallance, B.A. and Finlay, B.B.

Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections

Vallance, B.A. and Matthaei, K.I. and Sanovic, S. and Young, I.G. and Collins, S.M.

IL-5 contributes to worm expulsion and muscle hypercontractility in a primary T. spiralis infection

Vallance, B.A. and Blennerhassett, P.A. and Deng, Y. and Matthaei, K.I. and Young, I.G. and Collins, S.M.

Stress, inflammation and the irritable bowel syndrome.

Collins, S.M. and Barbara, G. and Vallance, B.

The role of CD4+ lymphocytes in the susceptibility of mice to stress- induced reactivation of experimental colitis

Nature Medicine

Qiu, B.S. and Vallance, B.A. and Blennerhassett, P.A. and Collins, S.M.

CD4 T cells and major histocompatibility complex class II expression influence worm expulsion and increased intestinal muscle contraction during Trichinella spiralis infection

Vallance, B.A. and Galeazzi, F. and Collins, S.M. and Snider, D.P.

Characterization of enteric functional changes evoked by in vivo anti- CD3 T cell activation

Radojevic, N. and McKay, D.M. and Merger, M. and Vallance, B.A. and Collins, S.M. and Croitoru, K.

Putative inflammatory and immunological mechanisms in functional bowel disorders

Collins, S.M. and Vallance, B. and Barbara, G. and Borgaonkar, M.

T cell-mediated exocrine pancreatic damage in major histocompatibility complex class II-deficient mice

Vallance, B.A. and Hewlett, B.R. and Snider, D.P. and Collins, S.M.

The effect of nematode infection upon intestinal smooth muscle function

Parasite Immunology

Vallance, B.A. and Collins, S.M.

T lymphocyte-dependent and -independent intestinal smooth muscle dysfunction in the T. spiralis-infected mouse

Vallance, B.A. and Croitoru, K. and Collins, S.M.

Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease

Hogaboam, C.M. and Vallance, B.A. and Kumar, A. and Addison, C.L. and Graham, F.L. and Gauldie, J. and Collins, S.M.

Persistent intestinal neuromuscular dysfunction after acute nematode infection in mice

Barbara, G. and Vallance, B.A. and Collins, S.M.

Increased intestinal muscle contractility and worm expulsion in nematode-infected mice

Vallance, B.A. and Blennerhassett, P.A. and Collins, S.M.

Role of smooth muscle in intestinal inflammation

Collins, S.M. and Khan, I. and Vallance, B. and Hogaboam, C. and Barbara, G.