Daniel L Metzger

MD

Investigator and Pediatric Endocrinologist, BC Children's Hospital

My research is primarily involved in the development, prevention and treatment of type 1 (insulin-dependent or juvenile-onset) diabetes. I am an investigator in several multicenter clinical trials involved in preventing type 1 diabetes.

I also maintain our Division's large website providing resources for families of children with diabetes and other endocrine disorders, and for the professionals caring for these patients.

Working with local and provincial resources, I have helped initiate an endocrine treatment program for transgender youth, and I am a Co-Investigator on a pan-Canadian study of these youth and their families (Trans Youth CAN!).

Academic Affiliations

  • Clinical Professor, Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases
  • Research Group(s): Diabetes

Contact Information

Location

4480 Oak St, Endocrinology & Diabetes Unit, Vancouver, BC, Canada, V6H 3V4

Experiences of Gender-Diverse Youth Living With Chronic Pain

Pediatrics

Boerner, K.E. and Fox, D.A. and Du, L. and Metzger, D.L. and Marshall, S. and Moore, E.M. and Narang, P. and Wharton, M.-N. and Oberlander, T.F.

DOI: 10.1542/peds.2024-067035

Individualized and innovative gender healthcare for transgender and nonbinary youth

Nature Reviews Endocrinology

Clark, D.B.A. and Metzger, D.L. and Pang, K.C. and St. Amand, C. and Khatchadourian, K.

DOI: 10.1038/s41574-025-01113-z

A Newborn With Severe and Refractory Hypoglycemia

Journal of Neonatology

Roychaudhuri, S. and Abdallateef, N. and Vijayashankar, S.S. and Tan, J. and Metzger, D. and Kieran, E.

DOI: 10.1177/09732179231172280

Unmet patient needs in monocarboxylate transporter 8 (MCT8) deficiency: a review

Frontiers in Pediatrics

Bauer, A.J. and Auble, B. and Clark, A.L. and Hu, T.Y. and Isaza, A. and McNerney, K.P. and Metzger, D.L. and Nicol, L. and Pierce, S.R. and Sidlow, R.

DOI: 10.3389/fped.2024.1444919

Response to the Letter to the Editor on the Canadian Paediatric Society statement on gender-affirming care

Paediatrics and Child Health Canada

Vandermorris, A. and Metzger, D. and Vyver, E. and Harrison, M. and Harvey, J.

DOI: 10.1093/pch/pxae066

An affirming approach to caring for transgender and gender-diverse youth,Une approche d'affirmation pour les soins aux jeunes transgenres et de diverses identits de genre

Paediatrics and Child Health (Canada)

Vandermorris, A. and Metzger, D.L.

DOI: 10.1093/pch/pxad046

An affirming approach to caring for transgender and gender-diverse youth

Paediatrics and Child Health (Canada)

Vandermorris, A. and Metzger, D.L.

DOI: 10.1093/pch/pxad045

Measuring severe obesity in pediatrics: A cohort study

Research Square

Ball, G.D.C. and Sharma, A.K. and Moore, S.A. and Metzger, D.L. and Klein, D. and Morrison, K.M.

DOI: 10.21203/rs.3.rs-2715882/v1

Measuring severe obesity in pediatrics using body mass index-derived metrics from the Centers for Disease Control and Prevention and World Health Organization: a secondary analysis of CANadian Pediatric Weight management Registry (CANPWR) data

European Journal of Pediatrics

Ball, G.D.C. and Sharma, A.K. and Moore, S.A. and Metzger, D.L. and Klein, D. and Morrison, K.M. and Buchholz, A. and Chanoine, J.-P. and Hamilton, J. and Ho, J. and Laberge, A.-M. and Legault, L. and Thabane, L. and Tremblay, M.S. and Zenlea, I.

DOI: 10.1007/s00431-023-05039-4

Reply

Journal of Pediatrics

Bauer, G.R. and Lawson, M.L. and Metzger, D.L.

DOI: 10.1016/j.jpeds.2022.03.004

Targeted treatment of immune thrombocytopenia in CTLA-4 insufficiency: a case report

British Journal of Haematology

Lai, C.M.B. and Setiadi, A. and Barlas, A. and Kanani, A. and Pourshahnazari, P. and Leitch, H.A. and Metzger, D.L. and Merkeley, H. and Biggs, C.M.

DOI: 10.1111/bjh.17866

Do Clinical Data from Transgender Adolescents Support the Phenomenon of Rapid Onset Gender Dysphoria?

Journal of Pediatrics

Bauer, G.R. and Lawson, M.L. and Metzger, D.L.

DOI: 10.1016/j.jpeds.2021.11.020

Endocrine treatment of transgender and gender-diverse people

British Columbia Medical Journal

Dahl, M. and Metzger, D.L.

Toward Building a Provincial Diabetes Registry of Children and Youth Living With Diabetes in British Columbia, Canada

Canadian Journal of Diabetes

Ayub, A. and Ng, C. and Portales-Casamar, E. and Metzger, D. and Amed, S.

DOI: 10.1016/j.jcjd.2021.11.006

Gender-affirming care in British Columbia, Part 2

British Columbia Medical Journal

Knudson, G. and Findlay, B. and Metzger, D.L.

Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk

Diabetologia

Nucci, A.M. and Virtanen, S.M. and Cuthbertson, D. and Ludvigsson, J. and Einberg, U. and Huot, C. and Castano, L. and Aschemeier, B. and Becker, D.J. and Knip, M. and Krischer, J.P. and Mandrup-Poulsen, T. and Arjas, E. and L{\"a}{\"a}r{\"a}, E. and Lernmark, ?. and Schmidt, B. and ?kerblom, H.K. and Hyytinen, M. and Koski, K. and Koski, M. and Pajakkala, E. and Salonen, M. and Shanker, L. and Bradley, B. and Dosch, H.-M. and Dupr{\'e}, J. and Fraser, W. and Lawson, M. and Mahon, J.L. and Sermer, M. and Taback, S.P. and Becker, D. and Franciscus, M. and Nucci, A. and Palmer, J. and Catteau, J. and Howard, N. and Crock, P. and Craig, M. and Clarson, C.L. and Bere, L. and Thompson, D. and Metzger, D. and Marshall, C. and Kwan, J. and Stephure, D.K. and Pacaud, D. and Schwarz, W. and Girgis, R. and Thompson, M. and Catte, D. and Lawson, M.L. and Bradley, B. and Daneman, D. and Sermer, M. and Martin, M.-J. and Morin, V. and Frenette, L. and Ferland, S. and Sanderson, S. and Heath, K. and Huot, C. and Gonthier, M. and Thibeault, M. and Legault, L. and Laforte, D. and Cummings, E.A. and Scott, K. and Bridger, T. and Crummell, C. and Houlden, R. and Breen, A. and Carson, G. and Kelly, S. and Sankaran, K. and Penner, M. and White, R.A. and King, N. and Popkin, J. and Robson, L. and Al Taji, E. and Mendlova, P. and Romanova, M. and Vavrinec, J. and Vosahlo, J. and Brazdova, L. and Venhacova, J. and Venhacova, P. and Cipra, A. and Tomsikova, Z. and Paterov{\'a}, P. and Gogelova, P. and Einberg, {\"U}. and Riikj{\"a}rv, M.-A. and Ormisson, A. and Tillmann, V. and Johansson, S. and Kleemola, P. and Parkkola, A. and J{\"a}rvenp{\"a}{\"a}, A.-L. and H{\"a}m{\"a}l{\"a}inen, A.-M. and Kiiveri, S. and Salonen, M. and Tenhola, S. and Salonen, P. and Jason, E. and Selvenius, J. and Siljander, H. and Ylitalo, S. and Paajanen, I. and Talvitie, T. and Lindstr{\"o}m, K. and Huopio, H. and Pesola, J. and Veijola, R. and Tapanainen, P. and Alar, A. and Popov, E. and Virransalo, R. and Nyk{\"a}nen, P. and Danne, T. and Kordonouri, O. and Krikovszky, D. and Mad{\'a}csy, L. and Khazrai, Y.M. and Maddaloni, E. and Pozzilli, P. and Mannu, C. and Songini, M. and de Beaufort, C. and Schierloh, U. and Bruining, J. and Bisschoff, M. and Basiak, A. and Wasikowa, R. and Ciechanowska, M. and Deja, G. and Jarosz-Chobot, P. and Szadkowska, A. and Cypryk, K. and Zawodniak-Szalapska, M. and Frutos, T.G. and Oyarzabal, M. and Serrano-R{\'i}os, M. and Mart{\'i}nez-Larrad, M.T. and Hawkins, F.G. and Arnau, D.R. and Konefal, M.S. and Hanas, R. and Lindblad, B. and Nilsson, N.-{\"O}. and Fors, H. and Nordwall, M. and Lindh, A. and Edenwall, H. and ?man, J. and Johansson, C. and Gadient, M. and Konrad, D. and Schoenle, E. and Becker, D. and Daftary, A. and Klein, M.B. and Gilmour, C. and Palmer, J. and Malone, P. and Tanner-Blasiar, M. and White, N. and Devaskar, U. and Horowitz, H. and Rogers, L. and Colon, R. and Frazer, T. and Torres, J. and Goland, R. and Greenberg, E. and Schachner, H. and Softness, B. and Ilonen, J. and Trucco, M. and Nichol, L. and Savilahti, E. and H{\"a}rk{\"o}nen, T. and Vaarala, O. and Luopaj{\"a}rvi, K. and Dosch, H.-M.

DOI: 10.1007/s00125-020-05358-3

Transgender youth referred to clinics for gender-affirming medical care in canada

Pediatrics

Bauer, G.R. and Pacaud, D. and Couch, R. and Metzger, D.L. and Gale, L. and Gotovac, S. and Mokashi, A. and Feder, S. and Raiche, J. and Speechley, K.N. and Newhook, J.T. and Ghosh, S. and Sansfacon, A.P. and Susset, F. and Lawson, M.L.

DOI: 10.1542/peds.2020-047266

Are there alternatives to over-the-counter diabetes-care glucose-gels for transitional neonatal hypoglycemia?

Paediatrics and Child Health (Canada)

Solimano, A. and Osiovich, H. and Kwan, E. and Metzger, D.L. and Everett, R.

DOI: 10.1093/pch/pxaa002

Prevalence of high blood pressure among Canadian Children: 2017 American Academy of Pediatrics guidelines with the Canadian Health Measures Survey

Paediatrics and Child Health (Canada)

Robinson, S.K. and Rodd, C.J. and Metzger, D.L. and Sharma, A.K.

DOI: 10.1093/pch/pxaa026

Isolated diastolic high blood pressure: a distinct clinical phenotype in US children

Pediatric Research

Alsaeed, H. and Metzger, D.L. and Blydt-Hansen, T.D. and Rodd, C. and Sharma, A.

DOI: 10.1038/s41390-021-01369-x

Precocious puberty: A red flag for malignancy in childhood

British Columbia Medical Journal

D?alessandro, P.R. and Hamilton, J. and Khatchadourian, K. and Lunaczek-Motyka, E. and Schultz, K.R. and Metzger, D. and Deyell, R.J.

Effects of Bisphosphonate Therapy on Bone Mineral Density in Boys with Duchenne Muscular Dystrophy.

Clinical medicine insights. Endocrinology and diabetes

Ronsley R and Islam N and Kang M and Nadel H and Reilly C and Metzger D and Selby K and Panagiotopoulos C

DOI: 10.1177/1179551420972400 PubMed: 33335437

12 / 2020

Fluid management in children with diabetic ketoacidosis.

Canadian family physician Medecin de famille canadien

McGregor S and Metzger DL and Amed S and Goldman RD

PubMed: 33208421

11 / 2020

Is Age a Risk Factor for Cerebral Edema in Children With Diabetic Ketoacidosis? A Literature Review

Canadian Journal of Diabetes

Glackin, S. and Metzger, D. and Hanas, R. and Chanoine, J.-P.

DOI: 10.1016/j.jcjd.2019.04.013

Fluid management in children with diabetic ketoacidosis,Prise en charge des liquides chez les enfants atteints dacidoctose diabtique

Canadian Family Physician

McGregor, S. and Metzger, D.L. and Amed, S. and Goldman, R.D.

Growth Hormone Supplementation and Psychosocial Functioning to Adult Height in Turner Syndrome: A Questionnaire Study of Participants in the Canadian Randomized Trial.

Frontiers in endocrinology

Rovet JF and Van Vliet G

DOI: 10.3389/fendo.2019.00125 PubMed: 30930850

03 / 2019

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial.

JAMA

Writing Group for the TRIGR Study Group and Knip M and kerblom HK and Al Taji E and Becker D and Bruining J and Castano L and Danne T and de Beaufort C and Dosch HM and Dupre J and Wasikowa R

DOI: 10.1001/jama.2017.19826 PubMed: 29297078

01 / 2018

Glucose control and autonomic response during acute stress in youth with type 1 diabetes: A pilot study

Pediatric Diabetes

Guan, L. and Metzger, D.L. and Lavoie, P.M. and Collet, J.-P.

DOI: 10.1111/pedi.12680

Prevalence and severity of high blood pressure among children based on the 2017 American academy of pediatrics guidelines

JAMA Pediatrics

Sharma, A.K. and Metzger, D.L. and Rodd, C.J.

DOI: 10.1001/jamapediatrics.2018.0223

Adherence to a pediatric diabetic ketoacidosis protocol in children presenting to a tertiary care hospital

Pediatric Diabetes

Ronsley, R. and Islam, N. and Ronsley, C. and Metzger, D.L. and Panagiotopoulos, C.

DOI: 10.1111/pedi.12556

WHO height charts can be safely substituted when calculating BP Z-scores in a North American clinic setting

Paediatrics and Child Health (Canada)

Rodd, C.J. and Metzger, D.L. and Sharma, A.K.

DOI: 10.1093/pch/pxx185

Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial

Maternal & Child Nutrition

DOI: 10.1111/mcn.12354

07 / 2017

Re: Young adult patients with diabetes presenting to a university health clinic with depression and anxiety

British Columbia Medical Journal

Metzger, D.L.

Hypogonadotropic hypogonadism in males with glycogen storage disease type 1

JIMD Reports

Wong, E.M. and Lehman, A. and Acott, P. and Gillis, J. and Metzger, D.L. and Sirrs, S.

DOI: 10.1007/8904_2016_38

Exome Sequencing and the Management of Neurometabolic Disorders.

The New England journal of medicine

Tarailo-Graovac M and Shyr C and Ross CJ and Horvath GA and Salvarinova R and Ye XC and Zhang LH and Bhavsar AP and Lee JJ and Drgemller BI and Abdelsayed M and Alfadhel M and van Karnebeek CD

DOI: 10.1056/nejmoa1515792 PubMed: 27276562

05 / 2016

Somatic mosaicism underlies X-linked acrogigantism syndrome in sporadic male subjects.

Endocrine-related cancer

Daly AF and Yuan B and Fina F and Caberg JH and Trivellin G and Rostomyan L and de Herder WW and Naves LA and Metzger D and Cuny T and Rabl W and Shah N and Jaffrain-Rea ML and Zatelli MC and Beckers A

DOI: 10.1530/erc-16-0082 PubMed: 26935837

03 / 2016

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.

Nature genetics

Onengut-Gumuscu S and Chen WM and Burren O and Cooper NJ and Quinlan AR and Mychaleckyj JC and Farber E and Bonnie JK and Szpak M and Schofield E and Achuthan P and Guo H and Rich SS

DOI: 10.1038/ng.3245 PubMed: 25751624

03 / 2015

X-linked acrogigantism syndrome: clinical profile and therapeutic responses.

Endocrine-related cancer

Beckers A and Lodish MB and Trivellin G and Rostomyan L and Lee M and Faucz FR and Yuan B and Choong CS and Caberg JH and Verrua E and Naves LA and Cheetham TD and Young J and Lysy PA and Stratakis CA

DOI: 10.1530/erc-15-0038 PubMed: 25712922

02 / 2015

Use of growth charts in Canada: A National Canadian Paediatric Surveillance Program survey

Paediatrics and Child Health (Canada)

Lawrence, S. and Cummings, E. and Chanoine, J.-P. and Metzger, D. and Palmert, M. and Sharma, A. and Rodd, C.

DOI: 10.1093/pch/20.4.185

Managing type 1 diabetes in school: Recommendations for policy and practice

Paediatrics and Child Health (Canada)

Lawrence, S.E. and Cummings, E.A. and Pacaud, D. and Lynk, A. and Metzger, D.L.

DOI: 10.1093/pch/20.1.35

Managing type 1 diabetes in school: Recommendations for policy and practice.

Paediatrics & child health

PubMed: 25722642

LMS tables for waist-circumference and waist-height ratio Z-scores in children aged 5-19 y in NHANES III: Association with cardio-metabolic risks

Pediatric Research

Sharma, A.K. and Metzger, D.L. and Daymont, C. and Hadjiyannakis, S. and Rodd, C.J.

DOI: 10.1038/pr.2015.160

Managing type 1 diabetes in school: Recommendations for policy and practice,Prise en charge du diabte de type 1 l'cole : Recommandations de politiques et de pratiques

Paediatrics and Child Health (Canada)

Lawrence, S.E. and Cummings, E.A. and Pacaud, D. and Lynk, A. and Metzger, D.L.

DOI: 10.1093/pch/20.1.40

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.

The New England journal of medicine

Trivellin G and Daly AF and Faucz FR and Yuan B and Rostomyan L and Larco DO and Schernthaner-Reiter MH and Szarek E and Leal LF and Caberg JH and Castermans E and Villa C and Stratakis CA

DOI: 10.1056/nejmoa1408028 PubMed: 25470569

12 / 2014

Hydrolyzed infant formula and early -cell autoimmunity: a randomized clinical trial.

JAMA

DOI: 10.1001/jama.2014.5610 PubMed: 24915259

06 / 2014

Provincial disparities of growth hormone coverage for young adult survivors of paediatric brain tumours across Canada.

Healthcare Policy

PubMed: 24726076

02 / 2014

Canadian endocrinologists views on growth hormone replacement therapy in adult survivors of pediatric brain tumours following achievement of final height

BC Medical Journal

Hasan H, Howard AF, Metzger DL, Gill S, Johnson M, Lo AC, Goddard K. Canadian endocrinologists views on growth hormone replacement therapy in adult survivors of pediatric brain tumours following achievement of final height. BC Med J 2014;56(5):230"235.

B7-H4 expression in normal and diseased human islet Cells

Pancreas

Cheung, S.S.C. and Ou, D. and Metzger, D.L. and Meloche, M. and Ao, Z. and Ng, S.S.W. and Owen, D. and Warnock, G.L.

DOI: 10.1097/MPA.0b013e31829695d2

Autosomal dominant hypoparathyroidism caused by germline mutation in GNA11: Phenotypic and molecular characterization

Journal of Clinical Endocrinology and Metabolism

Li, D. and Opas, E.E. and Tuluc, F. and Metzger, D.L. and Hou, C. and Hakonarson, H. and Levine, M.A.

DOI: 10.1210/jc.2014-1029

Provincial disparities of growth hormone coverage for young adult survivors of paediatric brain tumours across Canada

Healthcare Policy

Hasan, H. and Howard, F. and Morgan, S.G. and Metzger, D.L. and Lo, A.C. and Goddard, K. and Gill, S. and Johnson, M.

DOI: 10.12927/hcpol.2014.23728

Clinical management of youth with gender dysphoria in vancouver

Journal of Pediatrics

Khatchadourian, K. and Amed, S. and Metzger, D.L.

DOI: 10.1016/j.jpeds.2013.10.068

Canadian endocrinologists' views on growth hormone replacement therapy in adult survivors of pediatric brain tumors following achievement of final height

British Columbia Medical Journal

Hasan, H. and Fuchsia Howard, A. and Metzger, D.L. and Gill, S. and Johnson, M. and Lo, A.C. and Goddard, K.

Brg1 Loss Attenuates Aberrant Wnt-Signalling and Prevents Wnt-Dependent Tumourigenesis in the Murine Small Intestine

PLoS Genetics

Holik, A.Z. and Young, M. and Krzystyniak, J. and Williams, G.T. and Metzger, D. and Shorning, B.Y. and Clarke, A.R.

DOI: 10.1371/journal.pgen.1004453

Extending World Health Organization weight-for-age reference curves to older children

BMC Pediatrics

Rodd, C. and Metzger, D.L. and Sharma, A. and Cummings, E. and Chanoine, J.-P. and Lawrence, S. and Palmert, M.

DOI: 10.1186/1471-2431-14-32

Case 2: Pimples in prepuberty: A five-year-old with an unusual cause of facial comedones

Paediatrics and Child Health (Canada)

Malhotra, N. and Khatchadourian, K. and Metzger, D. and Lam, J.M.

DOI: 10.1093/pch/18.2.91a

Occurrence of slipped capital femoral epiphysis in children undergoing gonadotropin-releasing hormone agonist therapy for the treatment of central precocious puberty

Hormone Research in Paediatrics

Inman, M. and Hursh, B.E. and Mokashi, A. and Pinto, T. and Metzger, D.L. and Cummings, E.A.

DOI: 10.1159/000351028

Canadian Pediatric Endocrine Group extension to WHO growth charts: Why bother?

Paediatrics and Child Health (Canada)

Lawrence, S. and Cummings, E. and Chanoine, J.-P. and Metzger, D.L. and Palmert, M. and Sharma, A. and Rodd, C.

DOI: 10.1093/pch/18.6.295 PubMed: 24421695

Endogenous expression of B7-H4 improves long-term murine islet allograft survival

Transplantation

Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Lee, I.-F. and Akhoundsadegh, N. and Ao, Z. and Chen, L. and Ou, D. and Verchere, C.B. and Warnock, G.L.

DOI: 10.1097/TP.0b013e318277229d

B7-H4 induces donor-specific tolerance in mouse islet allografts

Cell Transplantation

Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Ao, Z. and Bruce Verchere, C. and Chen, L. and Ou, D. and Warnock, G.L.

DOI: 10.3727/096368911X582750

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

Nature Genetics

Hunt, K.A. and Smyth, D.J. and Balschun, T. and Ban, M. and Mistry, V. and Ahmad, T. and Anand, V. and Barrett, J.C. and Bhaw-Rosun, L. and Bockett, N.A. and Brand, O.J. and Brouwer, E. and Concannon, P. and Cooper, J.D. and Dias, K.-R.M. and Van Diemen, C.C. and Dubois, P.C. and Edkins, S. and F{\"o}lster-Holst, R. and Fransen, K. and Glass, D.N. and Heap, G.A.R. and Hofmann, S. and Huizinga, T.W.J. and Hunt, S. and Langford, C. and Lee, J. and Mansfield, J. and Marrosu, M.G. and Mathew, C.G. and Mein, C.A. and M{\"u}ller-Quernheim, J. and Nutland, S. and Onengut-Gumuscu, S. and Ouwehand, W. and Pearce, K. and Prescott, N.J. and Posthumus, M.D. and Potter, S. and Rosati, G. and Sambrook, J. and Satsangi, J. and Schreiber, S. and Shtir, C. and Simmonds, M.J. and Sudman, M. and Thompson, S.D. and Toes, R. and Trynka, G. and Vyse, T.J. and Walker, N.M. and Weidinger, S. and Zhernakova, A. and Zoledziewska, M. and Weersma, R.K. and Gough, S.C.L. and Sawcer, S. and Wijmenga, C. and Parkes, M. and Cucca, F. and Franke, A. and Deloukas, P. and Rich, S.S. and Todd, J.A. and Van Heel, D.A. and Baskerville, T. and Bautista, N. and Bhatia, E. and Bhatia, V. and Hasan, K.B. and Bonnici, F. and Brodnicki, T. and Browning, B. and Cameron, F. and Chaichanwatanakul, K. and Cheung, P.T. and Colman, P. and Cotterill, A. and Couper, J. and Crock, P. and Cutfield, R. and Davis, T. and Dixon, P. and Donaghue, K. and Dowling, K. and Drury, P. and Dye, S. and Gellert, S. and Ghani, R.A. and Greer, R. and Han, X. and Harrison, L. and Homatopoulos, N. and Ji, L. and Jones, T. and Yin, L.K. and Kamaruddin, N.A. and Kanga, U. and Kanungo, A. and Kaur, G. and Kek, B. and Knowles, S. and Krebs, J. and Kumar, N. and Lee, Y.-J. and Li, X. and Liktimaskul, S. and Lloyd, M. and Loth, A. and Louey, A. and Mehra, N. and Merriman, T. and Min, L. and Morahan, G. and Moses, R. and Mraz, G. and Murphy, R. and Nicholson, I. and Panelo, A. and Poh, P. and Price, G. and Ratnam, N. and Sanjeevi, C. and Sedimbi, S. and Shen, S. and Ying, G.S. and Tait, B. and Tandon, N. and Thomas, A. and Varney, M. and Weerakulwattana, P. and Willis, J. and Akwo, E.A. and Albret, L. and Ampudia-Blasco, F. and Argente, J. and Avbelj, M. and Babadjanova, G. and Badenhoop, K. and Battelino, T. and Beilhack, G. and Bergholdt, R. and Bingley, P. and Boehm, B. and Bolidson, J. and Brismar, K. and Brorsson, C. and Carlson, J. and Castano, L. and Chandler, K. and Cherubini, V. and Cinek, O. and Cipponeri, E. and Collado, R.C. and de Leiva, A. and Dzivite, I. and Fagulha, A. and Balcells, M.F. and Cuartero, B.G. and Lacalle, C.G. and Guja, C. and Guti{\'e}rrez, P. and Hamou, A. and Hatziagelaki, E. and Heath, S. and Heilman, K. and Helmberg, W. and Hermon, O. and Hernandez, M. and Holzheu, I. and Hosszufalusi, N. and Ilonen, J. and Ionescu-Tirgoviste, C. and Johannesen, J. and Julier, C. and Kahles, H. and Kinalska, I. and Knip, M. and Kockum, I. and Kojo, E. and Kordonouri, O. and Kretowski, A. and Krikovszky, D. and Kurkhaus, A. and Kuzmicki, M. and Lavant, E. and Long, A. and Ludvigsson, J. and Madacsy, L. and Maliszewska, K. and Marga, M. and Martinez, M.P. and Mauricio, D. and Mazurkievicz, G. and Nerup, J. and Norkus, A. and Mogollon, F.J.N. and Okruszko, A. and Pettinari, C. and Phillip, M. and Pirags, V. and Pociot, F. and Pozzilli, P. and Racasan, R. and Raile, K. and Rappner, R. and Troyano, M.J.R. and Roep, B.O. and Rokni, S. and Rosinger, S. and Rubio-Cabezas, O. and Ruckgaber, C. and Satman, I. and Schober, E. and Seufert, J. and Sing, R. and Skrha, J. and Sobngwi, E. and Somerville, M. and Spinas, G. and Sumnik, Z. and Tillmann, V. and Undlien, D. and Urbanavicius, V. and Van der Auwera, B. and Miguel, F.V.S. and Vazeo-Gerasimidi, A. and Velickiene, D. and W{\"a}gner, A. and Walter, M. and Williams, A. and Ziegler, A. and Agleham, M. and Aldrich, A. and Alemzadeh, R. and Alper, C. and Aly, T. and Anastassiou, D. and Arora, S. and Austin, A. and Becker, D. and Benoist, C. and Berka, N. and Bhatia, S. and Bonella, P. and Bottini, N. and Boyle, S. and Braden, J. and Brady, B. and Brickman, W. and Christensen, R. and Couch, R. and Counts, D. and Crandall, J. and Daniels, M. and Dolan, L. and Donaldson, D. and Doria, A. and Eisenbarth, G. and Elder, J. and El-Hajj, R. and Erlich, H. and Fain, P. and Fear, A.L. and Ferry, R. and Fiallo-Scharer, R. and Geraghty, D. and Ghosh, S. and Gitelman, S. and Godwin, M. and Goland, R. and Goodman, N. and Goodwin, G. and Gravely, J. and Greenbaum, C. and Gudgeon, C. and Gunville, F. and Hagopian, W. and Hakonarson, H. and Hansen, J. and Harrington, K. and Hassing, J. and Hilliker, W. and Hoffman, R. and Hulbert, E. and Izquierdo, R. and Jospe, N. and Kaiserman, K. and Kaufman, F. and Kim, S. and Kloos, E. and Kosoy, R. and Lane, J. and Lane, J. and Lawrence, J. and Levetan, C. and Levin, P. and Lipton, R. and Lonsdale, J. and Magnuson, V. and Marks, J. and Mayer-Davis, B. and McEvoy, R. and McIndoe, R. and Merkle, L. and Metzger, D. and Miao, D. and Mickelson, E. and Moonsamy, P. and Moore, W. and Moran, A. and Noble, J. and Olsem, G. and Orban, T. and Orlowski, C. and Paterson, A. and Pietropaolo, M. and Pihoker, C. and Polychronakos, C. and Post, J. and Postellon, D. and Pugliese, A. and Qu, H.Q. and Quattrin, T. and Rappaport, M. and Raskin, P. and Risbeck, H. and Rodriguez, H. and Rodriguez, L. and Rogers, M. and Rubalcava, L. and Russell, B. and Schatz, D. and Scott, C. and She, J.-X. and Shilling, H. and Shulman, D. and Soyka, L. and Speiser, P. and Starkman, H. and Steck, A. and Stender, S. and Stratton, L. and Sur, D. and Taback, S. and Thrailkill, K. and Toth, E. and Trymbiski, P. and Tsalikian, E. and Vertachnik, K. and Wahlen, J. and Wang, X. and Weber, S. and Wherrett, D. and Willi, S. and Wilson, D. and Youkey, J. and Young, N. and Yu, L. and Zhao, L.P. and Zimmerman, D. and Adlem, E. and Allen, J. and Brown, J. and Burren, O. and Clarke, P. and Clayton, D. and Coleman, G. and Davison, L. and Downes, K. and Duley, S. and Dunger, D. and Esposito, L. and Everett, V. and Field, S. and Hafler, J. and Hardy, M. and Harrison, D. and Harrison, I. and Hawkins, S. and Healy, B. and Hood, S. and Howell, S. and Howson, J. and Maisuria, M. and Meadows, W. and Nezhenstsev, S. and Ovington, N. and Plagnol, V. and Rainbow, D. and Rainbow, K. and Raj, S. and Schuilenburg, H. and Simpson, A. and Smink, L. and Stevens, H. and Taylor, N. and Tuomilehto, J. and Wicker, L. and Widmer, B. and Wilson, M. and Withers, H. and Yang, J. and Brown, M. and Chen, W.-M. and Crews, A. and Griffin, J. and Hall, M. and Harnish, T. and Hepler, J. and Hilner, J. and King, N. and Lohman, K. and Lu, L. and Mychaleckyj, J. and Nail, J. and Perdue, L. and Pierce, J. and Reboussin, D. and Rushing, S. and Sale, M. and Sides, E. and Snively, B. and Teuschler, H. and Theil, G. and Wagenknecht, L. and Williams, D. and Akolkar, B. and McKeon, C. and Nierras, C. and Thomson, E. and Altshuler, D. and Au, K. and Bain, S. and Barcellos, L. and Barral, S. and Becker, T. and Briggs, F. and Bronson, P. and Daly, M. and de Bakker, P. and Devlin, B. and Eike, M.C. and Field, L. and Gabriel, S. and Garge, N. and Gaudieri, S. and Goldstein, B. and Gorodezky, C. and Hamon, S. and He, C. and Humphreys, K. and James, I. and Lathrop, M. and Lie, B.A. and Li, D. and Mack, S. and McGinnis, R. and McKinnon, E. and McLaren, W. and Nolan, D. and Olsson, M. and Ott, J. and Owerbach, D. and Patterson, C. and Podolsky, R. and Ramsay, P. and Rangantah, V. and Risch, N. and Ronningen, S. and Shao, X. and Single, R. and Steffes, M. and Thomson, G. and Valdes, A.M. and Vandiedonck, C. and Whittaker, P. and Zhang, Q. and Anderson, C. and Drummond, H.E. and Edwards, C. and Harrison, K.L. and Henderson, P. and Lees, C. and Mathew, C.G. and Mowat, C. and Newman, W. and Nimmo, E.R. and Phillips, A. and Russell, R. and Sanderson, J. and Wilson, D.C. and Zhang, H. and Brown, M.A. and Burton, P.R. and Caulfield, M.J. and Craddock, N. and Compston, A. and Duncanson, A. and Hall, A.S. and Hattersley, A.T. and Hill, A.V.S. and Hurles, M. and Kwiatkowski, D.P. and McCarthy, M. and Pembrey, M. and Rahman, N. and Samani, N.J. and Satsangi, J. and Stratton, M.R. and Worthington, J. and Donnelly, P.

DOI: 10.1038/ng.1037

Generation of transplantable beta cells for patient-specific cell therapy

International Journal of Endocrinology

Wang, X. and Metzger, D.L. and Meloche, M. and Hao, J. and Ao, Z. and Warnock, G.L.

DOI: 10.1155/2012/414812

B7-H4 induces donor-specific tolerance in mouse islet allografts.

Cell transplantation

DOI: 10.3727/096368912x633815 PubMed: 21929869

When genetic load does not correlate with phenotypic spectrum: Lessons from the GnRH receptor (GNRHR)

Journal of Clinical Endocrinology and Metabolism

Gianetti, E. and Hall, J.E. and Au, M.G. and Kaiser, U.B. and Quinton, R. and Stewart, J.A. and Metzger, D.L. and Pitteloud, N. and Mericq, V. and Merino, P.M. and Levitsky, L.L. and Izatt, L. and Lang-Muritano, M. and Fujimoto, V.Y. and Dluhy, R.G. and Chase, M.L. and Crowley Jr., W.F. and Plummer, L. and Seminara, S.B.

DOI: 10.1210/jc.2012-1264

Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival

Islets

Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Lee, I.-F. and Akhoundsadegh, N. and Chen, C.L. and Ou, D. and Ao, Z. and Verchere, C.B. and Warnock, G.L.

DOI: 10.4161/isl.21239

B7-H4 treatment of t cells inhibits erk, jnk, p38, and akt activation

PLoS ONE

Wang, X. and Hao, J. and Metzger, D.L. and Ao, Z. and Chen, L. and Ou, D. and Verchere, C.B. and Mui, A. and Warnock, G.L.

DOI: 10.1371/journal.pone.0028232

B7-H4 Pathway in Islet Transplantation and -Cell Replacement Therapies.

Journal of transplantation

DOI: 10.1155/2011/418902 PubMed: 22028949

Validation of diabetes case definitions using administrative claims data

Diabetic Medicine

Amed, S. and Vanderloo, S.E. and Metzger, D. and Collet, J.-P. and Reimer, K. and Mccrea, P. and Johnson, J.A.

DOI: 10.1111/j.1464-5491.2011.03238.x

Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/ pheochromocytoma syndrome

Pediatric Radiology

Levine, D.S. and Metzger, D.L. and Nadel, H.R. and Oviedo, A. and Adam, M.J. and Skarsgard, E.

DOI: 10.1007/s00247-011-2109-0

Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes

Diabetes

Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Ao, Z. and Akhoundsadegh, N. and Langermann, S. and Liu, L. and Chen, L. and Ou, D. and Verchere, C.B. and Warnock, G.L.

DOI: 10.2337/db11-0375

Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC).

Clinical trials (London, England)

Hilner JE and Perdue LH and Sides EG and Pierce JJ and Wgner AM and Aldrich A and Loth A and Albret L and Wagenknecht LE and Nierras C and Akolkar B and T1DGC

DOI: 10.1177/1740774510373497 PubMed: 20603248

07 / 2010

Diabetic ketoacidosis in children and adolescents: an update and revised treatment protocol

BC Medical Journal

II. Metzger DL. Diabetic ketoacidosis in children and adolescents: an update and revised treatment protocol. BC Med J 2010;52(1):24"31 (invited review).

Methylation profiling in individuals with Russell-Silver syndrome

American Journal of Medical Genetics, Part A

Peaherrera, M.S. and Weindler, S. and Van Allen, M.I. and Yong, S.-L. and Metzger, D.L. and McGillivray, B. and Boerkoel, C. and Langlois, S. and Robinson, W.P.

DOI: 10.1002/ajmg.a.33204

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Nature Genetics

DOI: 10.1038/ng.381

06 / 2009

Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse

Genesis

Wendling, O. and Bornert, J.-M. and Chambon, P. and Metzger, D.

DOI: 10.1002/dvg.20448

Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival

Transplantation

Wang, X. and Hao, J. and Metzger, D.L. and Mui, A. and Ao, Z. and Verchere, C.B. and Chen, L. and Ou, D. and Warnock, G.L.

DOI: 10.1097/TP.0b013e318195e5fa

Twenty-one additional cases of familial renal glucosuria: Absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion

Nephrology Dialysis Transplantation

Calado, J. and Sznajer, Y. and Metzger, D. and Rita, A. and Hogan, M.C. and Kattamis, A. and Scharf, M. and Tasic, V. and Greil, J. and Brinkert, F. and Kemper, M.J. and Santer, R.

DOI: 10.1093/ndt/gfn386

Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR)

Pediatric Diabetes

DOI: 10.1111/j.1399-5448.2007.00239.x

06 / 2007

The TRIGR Trial: Testing the Potential Link between Weaning Diet and Type 1 Diabetes

Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry

DOI: 10.2174/187152207780832315

06 / 2007

Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure

American Journal of Medical Genetics, Part A

Bretherick, K.L. and Metzger, D.L. and Chanoine, J.-P. and Panagiotopoulos, C. and Watson, S.K. and Lam, W.L. and Fluker, M.R. and Brown, C.J. and Robinson, W.P.

DOI: 10.1002/ajmg.a.31679

Autosomal dominant pseudohypoaldosteronism type 1: Mechanisms, evidence for neonatal lethality, and phenotypic expression in adults

Journal of the American Society of Nephrology

Geller, D.S. and Zhang, J. and Zennaro, M.-C. and Vallo-Boado, A. and Rodriguez-Soriano, J. and Furu, L. and Haws, R. and Metzger, D. and Botelho, B. and Karaviti, L. and Haqq, A.M. and Corey, H. and Janssens, S. and Corvol, P. and Lifton, R.P.

DOI: 10.1681/ASN.2005111188

Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism

Proceedings of the National Academy of Sciences of the United States of America

Pitteloud, N. and Acierno Jr., J.S. and Meysing, A. and Eliseenkova, A.V. and Ma, J. and Ibrahimi, O.A. and Metzger, D.L. and Hayes, F.J. and Dwyer, A.A. and Hughes, V.A. and Yialamas, M. and Hall, J.E. and Grant, E. and Mohammadi, M. and Crowley Jr., W.F.

DOI: 10.1073/pnas.0600962103

Suppression of human T-cell responses to -cells by activation of B7-H4 pathway

Cell Transplantation

Ou, D. and Wang, X. and Metzger, D.L. and Ao, Z. and Pozzilli, P. and James, R.F.L. and Chen, L. and Warnock, G.L.

DOI: 10.3727/000000006783981837

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

Diabetes care

DOI: 10.2337/diacare.28.5.1068 PubMed: 15855569

05 / 2005

Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: Clinical characterization and exclusion of candidate loci

Journal of Clinical Endocrinology and Metabolism

Grasberger, H. and Mimouni-Bloch, A. and Vantyghem, M.-C. and Van Vliet, G. and Abramowicz, M. and Metzger, D.L. and Abdullatif, H. and Rydlewski, C. and Macchia, P.E. and Scherberg, N.H. and Van Sande, J. and Mimouni, M. and Weiss, R.E. and Vassart, G. and Refetoff, S.

DOI: 10.1210/jc.2005-0572

Synergistic inhibition of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human pancreatic cells by Bcl-2 and X-linked inhibitor of apoptosis

Human Immunology

Ou, D. and Wang, X. and Metzger, D.L. and James, R.F.L. and Pozzilli, P. and Plesner, A. and Korneluk, R.G. and Verchere, C.B. and Tingle, A.J.

DOI: 10.1016/j.humimm.2004.12.002

Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia

Journal of the American Society of Nephrology

Schlingmann, K.P. and Sassen, M.C. and Weber, S. and Pechmann, U. and Kusch, K. and Pelken, L. and Lotan, D. and Syrrou, M. and Prebble, J.J. and Cole, D.E.C. and Metzger, D.L. and Rahman, S. and Tajima, T. and Shu, S.-G. and Waldegger, S. and Seyberth, H.W. and Konrad, M.

DOI: 10.1681/ASN.2004110989

Oculorespiratory syndrome after influenza immunization in children

Pediatric Infectious Disease Journal

Skowronski, D.M. and Bjornson, G. and Husain, E. and Metzger, D.L. and Scheifele, D.W.

DOI: 10.1097/01.inf.0000148924.89558.d5

Regulation of TNF-related apoptosis-inducing ligand-mediated death-signal pathway in human cells by Fas-associated death domain and nuclear factor B

Human Immunology

Ou, D. and Wang, X. and Metzger, D.L. and Robbins, M. and Huang, J. and Jobin, C. and Chantler, J.K. and James, R.F.L. and Pozzilli, P. and Tingle, A.J.

DOI: 10.1016/j.humimm.2005.03.009

Tumor necrosis factor-related apoptosis-inducing ligand and CD56 expression in patients with type 1 diabetes mellitus

Pancreas

Cheung, S.-S.C. and Metzger, D.L. and Wang, X. and Huang, J. and Tai, J. and Tingle, A.J. and Ou, D.

DOI: 10.1097/01.mpa.0000148515.77497.4b

Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY).

Clinical and investigative medicine. Medecine clinique et experimentale

PubMed: 15305805

06 / 2004

Long on QT and low on calcium

Cardiology in the Young

Bradley, T.J. and Metzger, D.L. and Sanatani, S.

DOI: 10.1017/S1047951104006134

Addisons disease in a child with systemic lupus erythematosus

Pediatric Rheumatology Online Journal

Ortiz"Alvarez O, Metzger DL, Malleson PN, Cabral DA, Tucker LB, Petty RE. Addisons disease in a child with systemic lupus erythematosus. Pediatr Rheum Online J 2004;2(2):134"139.

Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY)

Clinical and Investigative Medicine

McKinney, J.L. and Cao, H. and Robinson, J.F. and Metzger, D.L. and Cummings, E. and Riddell, D.C. and Sanderson, S.R. and Pacaud, D. and Ho, J. and Hegele, R.A.

Current approaches to the prevention of type 1 diabetes

British Columbia Medical Journal

Metzger, D.L.

Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis

Biology of Reproduction

Weber, P. and Schuler, M. and Grard, C. and Mark, M. and Metzger, D. and Chambon, P.

DOI: 10.1095/biolreprod.102.005801

Weekly Telephone Contact by a Diabetes Educator in Adolescents with Type 1 Diabetes

Canadian Journal of Diabetes

Panagiotopoulos, C. and Preston, J.M. and Stewart, L.L. and Metzger, D.L. and Chanoine, J.-P.

Telephone contact by a diabetes nurse educator improves hemoglobin A1c in adolescents with poorly controlled type 1 diabetes: a randomized controlled trial

Canadian Journal of Diabetes

Panagiotopoulos C, Preston JM, Stewart LL, Metzger DL, Chanoine J"P. Telephone contact by a diabetes nurse educator improves hemoglobin A1c in adolescents with poorly controlled type 1 diabetes: a randomized controlled trial. Can J Diabetes 2003;27(4):422"427.

Effects of insulin in relatives of patients with type 1 diabetes mellitus.

The New England journal of medicine

DOI: 10.1056/nejmoa012350 PubMed: 12037147

05 / 2002

GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young (MODY)

Human mutation

Cao, H. and Shorey, S. and Robinson, J. and Metzger, D.L. and Stewart, L. and Cummings, E. and Hegele, R.A.

DOI: 10.1002/humu.9090

TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction

Diabetologia

Ou, D. and Metzger, D.L. and Wang, X. and Huang, J. and Pozzilli, P. and Tingle, A.J.

DOI: 10.1007/s00125-002-0926-2

-cell antigen-specific CD56+ NKT cells from type 1 diabetic patients: Autoaggressive effector T cells damage human CD56+ cells by HLA-restricted and non-HLA-restricted pathways

Human Immunology

Ou, D. and Metzger, D.L. and Wang, X. and Pozzilli, P. and Tingle, A.J.

DOI: 10.1016/S0198-8859(02)00372-5

Spectrum of mutations of the AAAS gene in Allgrove syndrome: lack of mutations in six kindreds with isolated resistance to corticotropin.

The Journal of clinical endocrinology and metabolism

DOI: 10.1210/jc.86.11.5433 PubMed: 11701718

11 / 2001

Spectrum of mutations of the AAAS gene in allgrove syndrome: Lack of mutations in six kindreds with isolated resistance to corticotropin

Journal of Clinical Endocrinology and Metabolism

Sandrini, F. and Farmakidis, C. and Kirschner, L.S. and Wu, S.-M. and Tullio-Pelet, A. and Lyonnet, S. and Metzger, D.L. and Bourdony, C.J. and Tiosano, D. and Chan, W.-Y. and Stratakis, C.A.

DOI: 10.1210/jcem.86.11.8037

High prevalence of celaic disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase

Canadian Journal of Gastroenterology

Gillett, P.M. and Gillett, H.R. and Israel, D.M. and Metzger, D.L. and Stewart, L. and Chanoine, J.-P. and Freeman, H.J.

DOI: 10.1155/2001/640796

Nine novel mutations in NR0B1 (DAX1) causing adrenal hypoplasia congenita.

Human mutation

Zhang, Y.H. and Huang, B.L. and Anyane-Yeboa, K. and Carvalho, J.A. and Clemons, R.D. and Cole, T. and De Figueiredo, B.C. and Lubinsky, M. and Metzger, D.L. and Quadrelli, R. and Repaske, D.R. and Reyno, S. and Seaver, L.H. and Vaglio, A. and Van Vliet, G. and McCabe, L.L. and McCabe, E.R. and Phelan, J.K.

DOI: 10.1002/humu.1236

Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus.

Diabetologia

DOI: 10.1007/s001250051373 PubMed: 10907121

06 / 2000

Erratum: Antenatal treatment for classic 21-hydroxylase forms of congenital adrenal hyperplasia and the issue (Genetics in Medicine (1999))

Genetics in Medicine

Travitz, J. and Metzger, D.

Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with Type I diabetes mellitus

Diabetologia

Ou, D. and Mitchell, L.A. and Metzger, D.L. and Gillam, S. and Tingle, A.J.

Increased prevalence of celiac disease in girls with Turner syndrome detected using antibodies to endomysium and tissue transglutaminase

Canadian Journal of Gastroenterology

Gilett, P.M. and Gilett, H.R. and Israel, D.M. and Metzger, D.L. and Stewart, L. and Chanoine, J.-P. and Freeman, H.J.

DOI: 10.1155/2000/172914

CD4+ and CD8+ T-cell clones from congenital Rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes: Implications for HLA class I and II allelic linkage to disease susceptibility

Human Immunology

Ou, D. and Jonsen, L.A. and Metzger, D.L. and Tingle, A.J.

DOI: 10.1016/S0198-8859(99)00037-3

Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor a

Molecular and Cellular Biology

Endoh, H. and Maruyama, K. and Masuhiro, Y. and Kobayashi, Y. and Goto, M. and Tai, H. and Yanagisawa, J. and Metzger, D. and Hashimoto, S. and Kato, S.

DOI: 10.1128/mcb.19.8.5363

Sex-Steroid"Hormone Modulation of the Somatotropic Axis During Normal Male Puberty

Sex-Steroid Interactions with Growth Hormone

Daniel L. Metzger and James R. Kerrigan

DOI: 10.1007/978-1-4612-1546-2_4

Antenatal treatment for classic 21-hydroxylase forms of congenital adrenal hyperplasia and the issues.

Genetics in medicine : official journal of the American College of Medical Genetics

PubMed: 11256677

A provincial protocol for the treatment of diabetic ketoacidosis in children

BC Medical Journal

Metzger DL. A provincial protocol for the treatment of diabetic ketoacidosis in children. BC Med J 1998;40(3):110"114.

Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement.

The Journal of Clinical Endocrinology and Metabolism

DOI: 10.1210/jcem.82.10.4317 PubMed: 9329378

10 / 1997

The short-term infusion of ovine corticotropin-releasing hormone does not alter luteinizing hormone concentrations in young adult men.

The Journal of Clinical Endocrinology and Metabolism

DOI: 10.1210/jcem.82.2.3782 PubMed: 9024279

02 / 1997

The short-term infusion of ovine corticotropin-releasing hormone does not alter luteinizing hormone concentrations in young adult men

Journal of Clinical Endocrinology and Metabolism

Metzger, D.L. and Kerrigan, J.R. and Rogol, A.D.

DOI: 10.1210/jc.82.2.697

Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth homone)-insulin- like growth factor I axis in the human: Evidence from pubertal pathophysiology and sex-steroid hormone replacement

Journal of Clinical Endocrinology and Metabolism

Veldhuis, J.D. and Metzger, D.L. and Martha Jr., P.M. and Mauras, N. and Kerrigan, J.R. and Keenan, B. and Rogol, A.D. and Pincus, S.M.

DOI: 10.1210/jc.82.10.3414

Estrogen and Diclofenac Sodium Therapy in a Prepubertal Female with Idiopathic Juvenile Osteoporosis

Journal of Pediatric Endocrinology and Metabolism

Wright, N.M. and Key, L.L. and Metzger, D.L.

DOI: 10.1515/JPEM.1995.8.2.135

The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis. Hepatopulmonary Syndrome Study Group.

Annals of internal medicine

DOI: 10.7326/0003-4819-121-1-199407010-00006 PubMed: 8198345

07 / 1994

Case 2

Archives of Pediatrics & Adolescent Medicine

Metzger, D.L. and Rogol, A.D.

DOI: 10.1001/archpedi.1994.02170070059010

Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: Evidence for a stimulatory role of endogenous estrogens during male adolescence

Journal of Clinical Endocrinology and Metabolism

Metzger, D.L. and Kerrigant, J.R.

DOI: 10.1210/jcem.79.2.8045971

The hepatopulmonary syndrome masquerading as pulmonary Langerhans-cell histiocytosis

Annals of Internal Medicine

Caldwell, S.H. and Brantley, K. and Dent, J. and Keeley, R.C. and Pruett, T. and Angle, J.F. and Gaffey, M. and Waldron, P. and Metzger, D.L. and Stevenson, W.C. and Ishitani, M. and Dickson, R.C. and Dye, K.R.

Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans. Mechanisms of androgen and estrogen action

Trends in Endocrinology and Metabolism

Metzger, D.L. and Kerrigan, J.R. and Rogol, A.D.

DOI: 10.1016/1043-2760(94)P3204-K

Cholinergic and opioid involvement in release of growth hormone during exercise and recovery.

Journal of applied physiology (Bethesda, Md. : 1985)

PubMed: 8226493

08 / 1993

Permanent neonatal diabetes mellitus and pancreatic exocrine insufficiency resulting from congenital pancreatic agenesis.

American journal of diseases of children (1960)

PubMed: 8506821

06 / 1993

Characterization of pulsatile secretion and clearance of plasma cortisol in premature and term neonates using deconvolution analysis

Journal of Clinical Endocrinology and Metabolism

Metzger, D.L. and Wright, N.M. and Veldhuis, J.D. and Rogol, A.D. and Kerrigan, J.R.

DOI: 10.1210/jcem.77.2.8345052

Permanent Neonatal Diabetes Mellitus and Pancreatic Exocrine Insufficiency Resulting From Congenital Pancreatic Agenesis

American Journal of Diseases of Children

Wright, N.M. and Metzger, D.L. and Borowitz, S.M. and Clarke, W.L.

DOI: 10.1001/archpedi.1993.02160300013005

Cholinergic and opioid involvement in release of growth hormone during exercise and recovery

Journal of Applied Physiology

Thompson, D.L. and Weltman, J.Y. and Rogol, A.D. and Metzger, D.L. and Veldhuis, J.D. and Weltman, A.

Alterations in the neuroendocrine control of growth hormone secretion in the uremic rat

Kidney International

Metzger, D.L. and Kerrigan, J.R. and Krieg Jr., R.J. and Chan, J.C.M. and Rogol, A.D.

DOI: 10.1038/ki.1993.146

Androgen receptor blockade with flutamide enhances growth hormone secretion in late pubertal males: Evidence for independent actions of estrogen and androgen

Journal of Clinical Endocrinology and Metabolism

Metzger, D.L. and Kerrigan, J.R.

DOI: 10.1210/jcem.76.5.8496305

Current Project

I am currently involved in a multicenter trial involved with the prevention of early treatment of type 1 diabetes: the Diabetes TrialNet.

I am a Co-Investigator on a pan-Canadian study of transgender youth and their families (Trans Youth CAN!).

Honours & Awards

Queen Elizabeth II Diamond Jubilee Medal — 2013

Patient & Family Centred Care Award, BCCH Partners in Care — 2013

Noni MacDonald Award from Paediatrics & Child Health (joint awardee) — 2014

Youth Friendly Care Award of Excellence, BCCH Youth Advisory Committee — 2015

Dr. Harvey Guyda Educator of the Year Award, Canadian Society of Endocrinology and Metabolism — 2016

American Academy of Pediatrics Special Achievement Award — 2018

American Academy of Pediatrics Special Achievement Award — 2021

Most Valuable Teaching Service Award, UBC/BCCH Department of Pediatrics — 2021

Dr. John Hunt Camping Spirit Award, Canadian Diabetes Association — 2004

Dr. Robert Volpé Distinguished Service Award, Canadian Society of Endocrinology and Metabolism — 2021

Education Award of Excellence with Distinction, C&W — 2006

Charles H. Best Award, Canadian Diabetes Association — 2006

Dr. Parminder Singh Award, British Columbia Pediatric Society — 2006

Family-Centred Care Award, BCCH Partners in Care — 2007

Diabetes Champion Certificate of Recognition, Canadian Diabetes Association — 2009

15 Years of Volunteering Recognition Award, Canadian Diabetes Association — 2012

Outstanding Achievement Award, Canadian Diabetes Association — 2003

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