Li Wang

(She/her)
MSc, MD, FRCPC

Investigator and Medical Biochemist, BC Children's Hospital
Chair, BCALP Biochemistry Science Section
President, Canadian Association of Medical Biochemists

As a medical biochemist, my research focuses on developing and validating new laboratory biomarkers for the diagnosis and prognosis of different diseases. Based on clinical and laboratory standards institute guidelines, I am interested in bringing these novel biomarkers to clinical laboratories which would meet the laboratory accreditation standards. Currently, I am conducting research related to transplantation immunology and peanut allergy. I am also interested in auditing how laboratory tests are utilized in healthcare systems and promote the cost-effectiveness of laboratory tests with evidence-based medicine.

Academic Affiliations

  • Clinical Professor, , Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases
  • Research Group(s): Clinical Practice, Outcomes and Innovation; Clinical and Community Data, Analytics and Informatics; Immunity in Health and Disease; Implementing Knowledge for Equity and System Change

Contact Information

Location

4480 Oak Street, Vancouver, British Columbia, Canada, V6H 3N1

An Overview of Pre-Analytical Factors Impacting Metabolomics Analyses of Blood Samples

Metabolites

Amy Thachil and Li Wang and Rupasri Mandal and David S Wishart and Tom Blydt-Hansen

DOI: 10.3390/metabo14090474

08 / 2024

Optimizing the approach to monitoring allograft inflammation using serial urinary CXCL10/creatinine testing in pediatric kidney transplant recipients

Pediatric Transplantation

Ella Barrett-Chan and Li Wang and Jeffrey Bone and Amy Thachil and Kevin Vytlingam and Tom Blydt-Hansen

DOI: 10.1111/petr.14718

05 / 2024

Interference of ketone bodies on laboratory creatinine measurement in children with DKA: a call for change in testing practices

Pediatric Nephrology

Damian Feldman-Kiss and Dailin Li and Richard Cleve and Graham Sinclair and Joshua A. Dubland and Li Wang

DOI: 10.1007/s00467-021-05324-0

06 / 2022

Intrapartum Fetal Scalp Lactate Testing: Considerations for Implementation and Clinical Decision Making

Journal of Obstetrics and Gynaecology Canada

Angela W.S. Fung and Andre Mattman and Li Wang and Teralee Burton and Lori A. Beach and A.K. Fzry

DOI: 10.1016/j.jogc.2021.06.006

11 / 2021

Comparative evaluation of neonatal bilirubin using Radiometer whole blood co-oximetry and plasma bilirubin methods from Roche Diagnostics and Ortho Clinical Diagnostics

Clinical Biochemistry

Ian Marie Lano and Andrew W. Lyon and Li Wang and Rob Ruskin and Martha E. Lyon

DOI: 10.1016/j.clinbiochem.2017.12.009

03 / 2018

Limitations and opportunities of whole blood bilirubin measurements by GEM premier 4000

BMC Pediatrics

Li Wang and Arianne Y. K. Albert and Benjamin Jung and Keyvan Hadad and Martha E. Lyon and Melanie Basso

DOI: 10.1186/s12887-017-0842-8

12 / 2017

Visual or automated dipstick testing for proteinuria in pregnancy?

Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Mauricio E. Correa and Anne-Marie Ct and Dane A. De Silva and Li Wang and Prianthiny Packianathan and Peter von Dadelszen and Laura A. Magee

DOI: 10.1016/j.preghy.2017.01.005

01 / 2017

Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin

Transplant Intern 2014 Nov; 27 (11):e115-7.

Transplant Intern 2014 Nov; 27 (11):e115-7.

DOI: 10.1111/tri.12384 PubMed: 24964219

11 / 2014

Hematocrit correction does not improve glucose monitor accuracy in the assessment of neonatal hypoglycemia.

Clinical chemistry and laboratory medicine

DOI: 10.1515/cclm-2012-0436 PubMed: 23420286

08 / 2013

Measurement uncertainty for serum free light chain assays: estimation and implication on result interpretation

Clinical Biochemistry

DOI: 10.1016/j.clinbiochem.2012.11.015 PubMed: 23200885

Assessing pneumatic tube systems with patient-specific populations and laboratory-derived criteria.

Clinical chemistry

DOI: 0.1373/clinchem.2011.179044 PubMed: 22291142

04 / 2012

Roche acetaminophen assay negative bias at low concentrations is imprvoved using the TDM diluent as the zero calibrator

Clinical Biochemistry

P. Kavsak and N. Wakefied and L. Clark and L. Lyko and R. Pickersgill and L. Wang and J. Zeidler

DOI: 10.1016/j.clinbiochem.2010.04.026

06 / 2010

Pediatric critical values: Laboratory"pediatrician discourse

Clinical Biochemistry

Andrew C. Don-Wauchope and Li Wang and Vijaylaxmi Grey

DOI: 10.1016/j.clinbiochem.2009.06.029

11 / 2009

Rescue of Munc18-1 and -2 Double Knockdown Reveals the Essential Functions of Interaction between Munc18 and Closed Syntaxin in PC12 Cells

Molecular Biology of the Cell

L. Han and T. Jiang and G. A. Han and N. T. Malintan and L. Xie and L. Wang and F. W. Tse and H. Y. Gaisano and B. M. Collins and F. A. Meunier and S. Sugita

DOI: 10.1091/mbc.e09-08-0712

10 / 2009

RalA and RalB Function as the Critical GTP Sensors for GTP-Dependent Exocytosis

Journal of Neuroscience

G. Li and L. Han and T.-C. Chou and Y. Fujita and L. Arunachalam and A. Xu and A. Wong and S.-K. Chiew and Q. Wan and L. Wang and S. Sugita

DOI: 10.1523/jneurosci.2537-06.2007

01 / 2007

N-Terminal Insertion and C-Terminal Ankyrin-Like Repeats of -Latrotoxin Are Critical for Ca2+-Dependent Exocytosis

Journal of Neuroscience

G. Li

DOI: 10.1523/jneurosci.3560-05.2005

11 / 2005

A Central Kinase Domain of Type I Phosphatidylinositol Phosphate Kinases Is Sufficient to Prime Exocytosis: ISOFORM SPECIFICITY AND ITS UNDERLYING MECHANISM

Journal of Biological Chemistry

L. Wang and G. Li and S. Sugita

DOI: 10.1074/jbc.m413263200

02 / 2005

RalA-Exocyst Interaction Mediates GTP-dependent Exocytosis

Journal of Biological Chemistry

Li Wang and Gang Li and Shuzo Sugita

DOI: 10.1074/jbc.m400522200

02 / 2004

Current Projects

1) Assessment of the cost-effectiveness of Ara h 2 and Arah 8 component testing for peanut allergy diagnosis in Canadian children
2) Clinical testing of urine CXCL-10 for children post kidney transplant to predict early kidney rejections
3) Application of whole blood bilirubin for the diagnosis of neonatal hyperbilirubinemia to reduce the length of hospital stay

Grants

2019: “A study of whether selectively ordering peanut component resolved diagnostics increases diagnostic accuracy in children in a cost-effective manner”, Dr. Donald B. Rix and Laboratory Medicine Research Grant

2018: "Optimization of pre-analytical issues relevant to urinary CXCL-10 measurements in clinical research”, BCCHR QI Grant

2017: “Fast, accurate bilirubin screening with only a drop of blood”, Medical & Allied Staff Engagement Society (MASES) Engagement Fund

Honours & Awards

Young Investigator Travel Award, MSACL (Association for Mass Spectrometry: Applications to the Clinical Lab), Salt Springs, USA. February 2016

NACB’s Distinguished Abstract Award, AACC (American Association of Clinical Chemistry) annual meeting, Atlanta, USA. July 2015

Best poster presentation, XIII International Congress of Pediatric Laboratory Medicine, Istanbul, Turkey. June 2014

First place for oral presentation, CAMB (Canadian Association of Medical Biochemists) annual meeting, Montreal, Canada. November 2012

First place for best case report/series presentation, Department of Pathology & Molecular Medicine, Resident Research Day, McMaster University. May 2012

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