BCCHR Researchers Find a Researcher

Rusung Tan

MD, FRCPC, PhD

Investigator Emeritus, BC Children's Hospital

Immune white cells, such as cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, protect us from infectious diseases and cancer by killing infected or unwanted cells. Conversely, defects in the function or regulation of these cells can lead to immunodeficiency or autoimmunity. Currently we are studying the role of these cells in two diseases: type 1 diabetes and X-linked lymphoproliferative disease. In both these disorders, we have described defects in CTL and NK cells. By identifying these defects in detail we hope that we will be able to develop novel therapies for disease.

Academic Affiliations

Professor Emeritus/a, Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia
Research Theme: No Theme Affiliation

Contact Information

(604) 875-3605

roo@mail.ubc.ca

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

Immunotherapy Advances

Marwaha, A.K. and Chow, S. and Pesenacker, A.M. and Cook, L. and Sun, A. and Long, S.A. and Yang, J.H.M. and Ward-Hartstonge, K.A. and Williams, E. and Domingo-Vila, C. and Halani, K. and Harris, K.M. and Tree, T.I.M. and Levings, M.K. and Elliott, T. and Tan, R. and Dutz, J.P.

DOI: 10.1093/immadv/ltab022

Virome-wide serological profiling reveals association of herpesviruses with obesity

Scientific Reports

Hasan, M.R. and Rahman, M. and Khan, T. and Saeed, A. and Sundararaju, S. and Flores, A. and Hawken, P. and Rawat, A. and Elkum, N. and Hussain, K. and Tan, R. and Tang, P. and Marr, N.

DOI: 10.1038/s41598-021-82213-4

A metagenomics-based diagnostic approach for central nervous system infections in hospital acute care setting

Scientific Reports

Hasan, M.R. and Sundararaju, S. and Tang, P. and Tsui, K.-M. and Lopez, A.P. and Janahi, M. and Tan, R. and Tilley, P.

DOI: 10.1038/s41598-020-68159-z

Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: A case report

BMC Infectious Diseases

Hasan, M.R. and Sundaram, M.S. and Sundararaju, S. and Tsui, K.-M. and Karim, M.Y. and Roscoe, D. and Imam, O. and Janahi, M.A. and Thomas, E. and Dobson, S. and Tan, R. and Tang, P. and Lopez, A.P.

DOI: 10.1186/s12879-020-04966-z

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis

Science Translational Medicine

Brook, B. and Harbeson, D.J. and Shannon, C.P. and Cai, B. and He, D. and Ben-Othman, R. and Francis, F. and Huang, J. and Varankovich, N. and Liu, A. and Bao, W. and Bjerregaard-Andersen, M. and Schaltz-Buchholzer, F. and Sanca, L. and Golding, C.N. and Larsen, K.L. and Levy, O. and Kampmann, B. and Tan, R. and Charles, A. and Wynn, J.L. and Shann, F. and Aaby, P. and Benn, C.S. and Tebbutt, S.J. and Kollmann, T.R. and Amenyogbe, N. and Lee, A.H. and Bennike, T.B. and Diray-Arce, J. and Idoko, O. and Pomat, W.S. and van Haren, S. and Cox, M. and Darboe, A. and Falsafi, R. and Hinshaw, S.H. and Ndure, J. and Njie-Jobe, J. and Pettengill, M.A. and Marchant, A. and Richmond, P.C. and Ford, R. and Saleu, G. and Masiria, G. and Matlam, J.P. and Kirarock, W. and Roberts, E. and Malek, M. and Sanchez-Schmitz, G. and Singh, A. and Angelidou, A. and Smolen, K.K. and Brinkman, R.R. and Ozonoff, A. and Hancock, R.E.W. and van den Biggelaar, A.H.J. and Steen, H. and Vo, D. and Kraft, K. and McEnaney, K. and Vignolo, S.

DOI: 10.1126/SCITRANSLMED.AAX4517

A novel real-time PCR assay panel for detection of common respiratory pathogens in a convenient, strip-tube array format

Journal of Virological Methods

Hasan, M.R. and Al Mana, H. and Young, V. and Tang, P. and Thomas, E. and Tan, R. and Tilley, P.

DOI: 10.1016/j.jviromet.2018.12.013

A Metagenomics " Based Diagnostic Approach for Central Nervous System Infections in Hospital Acute Care Setting

bioRxiv

Hasan, M.R. and Sundararaju, S. and Tang, P. and Tsui, K.-M. and Lopez, A.P. and Janahi, M. and Tan, R. and Tilley, P.

DOI: 10.1101/752618

Treg gene signatures predict and measure type 1 diabetes trajectory

JCI Insight

Pesenacker, A.M. and Chen, V. and Gillies, J. and Speake, C. and Marwaha, A.K. and Sun, A. and Chow, S. and Tan, R. and Elliott, T. and Dutz, J.P. and Tebbutt, S.J. and Levings, M.K.

DOI: 10.1172/jci.insight.123879

Profiling of circulating microRNAs in children with recent onset of type 1 diabetes

JCI Insight

Suheda Erener and Ashish Marwaha and Rusung Tan and Constadina Panagiotopoulos and Timothy J. Kieffer

DOI: 10.1172/jci.insight.89656

02 / 2017

Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3⁺ IL-17⁺ cells

Genes and Immunity

Marwaha, A.K. and Panagiotopoulos, C. and Biggs, C.M. and Staiger, S. and Del Bel, K.L. and Hirschfeld, A.F. and Priatel, J.J. and Turvey, S.E. and Tan, R.

DOI: 10.1038/gene.2016.44

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression

Journal of Clinical Investigation

Patterson, S.J. and Pesenacker, A.M. and Wang, A.Y. and Gillies, J. and Mojibian, M. and Morishita, K. and Tan, R. and Kieffer, T.J. and Verchere, C.B. and Panagiotopoulos, C. and Levings, M.K.

DOI: 10.1172/JCI83987

Comparative evaluation of laboratory developed real-time PCR assays and RealStar BKV PCR Kit for quantitative detection of BK polyomavirus

Journal of Virological Methods

Hasan, M.R. and Tan, R. and Al-Rawahi, G. and Thomas, E. and Tilley, P.

DOI: 10.1016/j.jviromet.2016.04.009

Depletion of human DNA in spiked clinical specimens for improvement of sensitivity of pathogen detection by next-generation sequencing

Journal of Clinical Microbiology

Hasan, M.R. and Rawat, A. and Tang, P. and Jithesh, P.V. and Thomas, E. and Tan, R. and Tilley, P.

DOI: 10.1128/JCM.03050-15

Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis

Brain

Van Luijn, M.M. and Kreft, K.L. and Jongsma, M.L. and Mes, S.W. and Wierenga-Wolf, A.F. and Van Meurs, M. and Melief, M.-J. and Van Der Kant, R. and Janssen, L. and Janssen, H. and Tan, R. and Priatel, J.J. and Neefjes, J. and Laman, J.D. and Hintzen, R.Q.

DOI: 10.1093/brain/awv080

Nocardia asteroides sinusitis in a pediatric patient: Case report with 20 year follow-up and review of the literature

International Journal of Pediatric Otorhinolaryngology

Sorichetti, B. and Westerberg, B.D. and Tan, R. and Kozak, F.K.

DOI: 10.1016/j.ijporl.2015.04.022

CCL22 prevents rejection of mouse islet allografts and induces donor-specific tolerance

Cell Transplantation

Montane, J. and Obach, M. and Alvarez, S. and Bischoff, L. and Dai, D.L. and Soukhatcheva, G. and Priatel, J.J. and Hardenberg, G. and Levings, M.K. and Tan, R. and Orban, P.C. and Verchere, C.B.

DOI: 10.3727/096368914X685249

CD1d expression and invariant NKT cell responses in herpesvirus infections

Frontiers in Immunology

Chung, B.K. and Priatel, J.J. and Tan, R.

DOI: 10.3389/fimmu.2015.00312

Natural killer T cell strategies to combat Epstein-Barr virus infection

OncoImmunology

Priatel, J.J. and Chung, B.K. and Tsai, K. and Tan, R.

DOI: 10.4161/onci.28329

Combined immunodeficiency associated with homozygous MALT1 mutations

Journal of Allergy and Clinical Immunology

McKinnon, M.L. and Rozmus, J. and Fung, S.-Y. and Hirschfeld, A.F. and Del Bel, K.L. and Thomas, L. and Marr, N. and Martin, S.D. and Marwaha, A.K. and Priatel, J.J. and Tan, R. and Senger, C. and Tsang, A. and Prendiville, J. and Junker, A.K. and Seear, M. and Schultz, K.R. and Sly, L.M. and Holt, R.A. and Patel, M.S. and Friedman, J.M. and Turvey, S.E.

DOI: 10.1016/j.jaci.2013.10.045

Evaluation of amplification targets for the specific detection of Bordetella pertussis using real-time polymerase chain reaction

Canadian Journal of Infectious Diseases and Medical Microbiology

Hasan, M.R. and Tan, R. and Al-Rawahi, G.N. and Thomas, E. and Tilley, P.

DOI: 10.1155/2014/763128

Insulin-producing intestinal K cells protect nonobese diabetic mice from autoimmune diabetes

Gastroenterology

Mojibian, M. and Lam, A.W.Y. and Fujita, Y. and Asadi, A. and Grassl, G.A. and Dickie, P. and Tan, R. and Cheung, A.T. and Kieffer, T.J.

DOI: 10.1053/j.gastro.2014.03.020

SLAM-SAP signaling promotes differentiation of IL-17-producing T cells and progression of experimental autoimmune encephalomyelitis

Journal of Immunology

Huang, Y.-H. and Tsai, K. and Ma, C. and Vallance, B.A. and Priatel, J.J. and Tan, R.

DOI: 10.4049/jimmunol.1301435

Innate immune control of EBV-infected B cells by invariant natural killer T cells

Blood

Chung, B.K. and Tsai, K. and Allan, L.L. and Zheng, D.J. and Nie, J.C. and Biggs, C.M. and Hasan, M.R. and Kozak, F.K. and Van Den Elzen, P. and Priatel, J.J. and Tan, R.

DOI: 10.1182/blood-2013-01-480665

Optimal use of MRSASelect and PCR to maximize sensitivity and specificity of MRSA detection

Current Microbiology

Hasan, M.R. and Brunstein, J.D. and Al-Rawahi, G. and Tan, R. and Thomas, E. and Tilley, P.

DOI: 10.1007/s00284-012-0241-1

Amino acid structure determines the immune responses generated by peptide-gold nanoparticle hybrids

Particle and Particle Systems Characterization

Yang, H. and Zhou, Y. and Fung, S.-Y. and Wu, L. and Tsai, K. and Tan, R. and Turvey, S.E. and Machuca, T. and De Perrot, M. and Waddell, T.K. and Liu, M.

DOI: 10.1002/ppsc.201300213

PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS)

Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Y. Hu and R. Yuen and G. Eastabrook and J. Dutz and R. Tan and P. von Dadelszen and W. Robinson

DOI: 10.1016/j.preghy.2012.04.176

07 / 2012

Decidual NK Cell-Derived Conditioned Medium (dNK-CM) Mediates VEGF-C Secretion in Extravillous Cytotrophoblasts

American Journal of Reproductive Immunology

Eastabrook, G.D.M. and Hu, Y. and Tan, R. and Dutz, J.P. and Maccalman, C.D. and Von Dadelszen, P.

DOI: 10.1111/j.1600-0897.2011.01075.x

Short-term stability of pathogen-specific nucleic acid targets in clinical samples

Journal of Clinical Microbiology

Hasan, M.R. and Tan, R. and Al-Rawahi, G.N. and Thomas, E. and Tilley, P.

DOI: 10.1128/JCM.02659-12

NKT cells are required for complete freund's adjuvant-mediated protection from autoimmune diabetes

Journal of Immunology

Lee, I.-F. and Van Den Elzen, P. and Tan, R. and Priatel, J.J.

DOI: 10.4049/jimmunol.1002551

The CaV1.4 Calcium Channel Is a Critical Regulator of T Cell Receptor Signaling and Naive T Cell Homeostasis

Immunity

Omilusik, K. and Priatel, J. and Chen, X. and Wang, Y. and Xu, H. and Choi, K. and Gopaul, R. and McIntyre-Smith, A. and Teh, H.-S. and Tan, R. and Bech-Hansen, N. and Waterfield, D. and Fedida, D. and Hunt, S. and Jefferies, W.

DOI: 10.1016/j.immuni.2011.07.011

CD1d and CD1c expression in human B cells is regulated by activation and retinoic acid receptor signaling

Journal of Immunology

Allan, L.L. and Stax, A.M. and Zheng, D.-J. and Chung, B.K. and Kozak, F.K. and Tan, R. and Van Den Elzen, P.

DOI: 10.4049/jimmunol.1003615

The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation

Virology

Kwun, H.J. and da Silva, S.R. and Qin, H. and Ferris, R.L. and Tan, R. and Chang, Y. and Moore, P.S.

DOI: 10.1016/j.virol.2011.01.026

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

Journal of Clinical Investigation

Montane, J. and Bischoff, L. and Soukhatcheva, G. and Dai, D.L. and Hardenberg, G. and Levings, M.K. and Orban, P.C. and Kieffer, T.J. and Tan, R. and Verchere, C.B.

DOI: 10.1172/JCI43048

Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling

Diabetes

Qin, H. and Lee, I.-F. and Panagiotopoulos, C. and Wang, X. and Chu, A.D. and Utz, P.J. and Priatel, J.J. and Tan, R.

DOI: 10.2337/db09-1706

Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes

Journal of Immunology

Marwaha, A.K. and Crome, S.Q. and Panagiotopoulos, C. and Berg, K.B. and Qin, H. and Ouyang, Q. and Xu, L. and Priatel, J.J. and Levings, M.K. and Tan, R.

DOI: 10.4049/jimmunol.1001860

RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells

Journal of Immunology

Priatel, J.J. and Chen, X. and Huang, Y.-H. and Chow, M.T. and Zenewicz, L.A. and Coughlin, J.J. and Shen, H. and Stone, J.C. and Tan, R. and Teh, H.S.

DOI: 10.4049/jimmunol.0803521

Decidual NK cell-derived conditioned medium enhances capillary tube and network organization in an extravillous cytotrophoblast cell line

Placenta

Hu, Y. and Eastabrook, G. and Tan, R. and MacCalman, C.D. and Dutz, J.P. and von Dadelszen, P.

DOI: 10.1016/j.placenta.2009.12.011

Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells

Blood

Allan, L.L. and Hoefl, K. and Zheng, D.-J. and Chung, B.K. and Kozak, F.K. and Tan, R. and Van Den Elzen, P.

DOI: 10.1182/blood-2009-04-211417

Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency

Clinical Immunology

Cuvelier, G.D.E. and Schultz, K.R. and Davis, J. and Hirschfeld, A.F. and Junker, A.K. and Tan, R. and Turvey, S.E.

DOI: 10.1016/j.clim.2009.01.003

Critical role for IFN- in natural killer cell-mediated protection from diabetes

European Journal of Immunology

Lee, I.-F. and Qin, H. and Priatel, J.J. and Tan, R.

DOI: 10.1002/eji.200737189

The X-linked lymphoproliferative syndrome gene product SAP regulates B cell function through the FcRIIB receptor

Cellular Signalling

Li, C. and Chung, B. and Tao, J. and Iosef, C. and Aoukaty, A. and Wang, Y. and Tan, R. and Li, S.S.-C.

DOI: 10.1016/j.cellsig.2008.07.004

IFN--mediated extravillous trophoblast outgrowth inhibition in first trimester explant culture: A role for insulin-like growth factors

Molecular Human Reproduction

Hu, Y. and Tan, R. and Maccalman, C.D. and Eastabrook, G. and Park, S.-H. and Dutz, J.P. and Von Dadelszen, P.

DOI: 10.1093/molehr/gan018

Xenogeneic 2-microglobulin substitution alters NK cell function

Journal of Immunology

Benot, L.A. and Tan, R.

DOI: 10.4049/jimmunol.179.3.1466

Xenogeneic 2-microglobulin substitution affects functional binding of MHC class I molecules by CD8+ T cells

Journal of Immunology

Benoit, L.A. and Tan, R.

DOI: 10.4049/jimmunol.179.6.3588

Prospective prediction of spontaneous but not recurrent autoimmune diabetes in the non-obese diabetic mouse

Diabetologia

Trudeau, J.D. and Chandler, T. and Soukhatcheva, G. and Verchere, C.B. and Tan, R.

DOI: 10.1007/s00125-007-0600-9

Recognition of HLA class I-restricted -cell epitopes in type 1 diabetes

Diabetes

Ouyang, Q. and Standifer, N.E. and Qin, H. and Gottlieb, P. and Verchere, C.B. and Nepom, G.T. and Tan, R. and Panagiotopoulos, C.

DOI: 10.2337/db06-0065

Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: A role for IFN-

Journal of Immunology

Hu, Y. and Dutz, J.P. and MacCalman, C.D. and Yong, P. and Tan, R. and Von Dadelszen, P.

DOI: 10.4049/jimmunol.177.12.8522

Identification of novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives

Diabetes

Standifer, N.E. and Ouyang, Q. and Panagiotopoulos, C. and Verchere, C.B. and Tan, R. and Greenbaum, C.J. and Pihoker, C. and Nepom, G.T.

DOI: 10.2337/db06-0066

Cutting edge: Signaling lymphocytic activation molecule-associated protein controls NKT cell functions

Journal of Immunology

Chung, B. and Aoukaty, A. and Dutz, J. and Terhorst, C. and Tan, R.

DOI: 10.4049/jimmunol.174.6.3153

The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts

Diabetes

Plesner, A. and Liston, P. and Tan, R. and Korneluk, R.G. and Verchere, C.B.

DOI: 10.2337/diabetes.54.9.2533

Current approaches for the prediction and identification of CD8 T-cell epitopes in type 1 diabetes

Current Opinion in Endocrinology and Diabetes

Standifer, N.E. and Panagiotopoulos, C. and Tan, R.

Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease

Journal of Immunology

Aoukaty, A. and Tan, R.

DOI: 10.4049/jimmunol.174.8.4551

Detection and enumeration of beta cell-specific cytotoxic T lymphocytes in type 1 diabetes: Is disease prediction possible?

Canadian Journal of Diabetes

Trudeau, J.D. and Panagiotopoulos, C. and Verchere, C.B. and Tan, R.

Current approaches for the prediction and identification of CD8 T cell epitopes in type 1 diabetes

Current Opinion in Endocrinology and Diabetes

N. Standifer, C. Panagiotopoulos and R. Tan. Current approaches for the prediction and identification of CD8 T cell epitopes in type 1 diabetes. Current Opinion in Endocrinology and Diabetes. 2005;12:298-302

DOI: 10.1097/01.med.0000169384.05495.20

Rapid and fatal meningococcal disease due to a strain of Neisseria meningitidis containing the capsule null locus.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Hoang, L.M. and Thomas, E. and Tyler, S. and Pollard, A.J. and Stephens, G. and Gustafson, L. and McNabb, A. and Pocock, I. and Tsang, R. and Tan, R.

DOI: 10.1086/427875

Murine CD160, Ig-like receptor on NK Cells and NKT cells, recognizes classical and nonclassical MHC class I and regulates NK cell activation

Journal of Immunology

Maeda, M. and Carpenito, C. and Russell, R.C. and Dasanjh, J. and Veinotte, L.L. and Ohta, H. and Yamamura, T. and Tan, R. and Takei, F.

DOI: 10.4049/jimmunol.175.7.4426

Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL

International Immunology

Qin, H. and Trudeau, J.D. and Reid, G.S.D. and Lee, I.-F. and Dutz, J.P. and Santamaria, P. and Verchere, C.B. and Tan, R.

DOI: 10.1093/intimm/dxh167

Regulation of Autoimmune Diabetes by Complete Freund's Adjuvant Is Mediated by NK Cells

Journal of Immunology

Lee, I.-F. and Qin, H. and Trudeau, J. and Dutz, J. and Tan, R.

DOI: 10.4049/jimmunol.172.2.937

Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR

Journal of Clinical Microbiology

Campsall, P.A. and Au, N.H.C. and Prendiville, J.S. and Speert, D.P. and Tan, R. and Thomas, E.E.

DOI: 10.1128/JCM.42.4.1409-1413.2004

T-cell epitopes in type 1 diabetes

Current Diabetes Reports

Panagiotopoulos, C. and Trudeau, J.D. and Tan, R.

DOI: 10.1007/s11892-004-0062-0

Molecular dissection of 2B4 signaling: Implications for signal transduction by SLAM-related receptors

Molecular and Cellular Biology

Chen, R. and Relouzat, F. and Roncagalli, R. and Aoukaty, A. and Tan, R. and Latour, S. and Veillette, A.

DOI: 10.1128/MCB.24.12.5144-5156.2004

Identification of a -Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes

Diabetes

Panagiotopoulos, C. and Qin, H. and Tan, R. and Verchere, C.B.

DOI: 10.2337/diabetes.52.11.2647

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

Journal of Clinical Investigation

Trudeau, J.D. and Kelly-Smith, C. and Verchere, C.B. and Elliott, J.F. and Dutz, J.P. and Finegood, D.T. and Santamaria, P. and Tan, R.

DOI: 10.1172/JCI200316409

Preventing tropical illness in elderly travellers: the older cruiser

Geriatrics and Aging

C. Penn and R. Tan. Preventing tropical illness in elderly travellers: the older cruiser. Geriatrics and Aging. 2003; 6:12-16.

Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells

Journal of Clinical Immunology

Aoukaty, A. and Lee, I.-F. and Wu, J. and Tan, R.

DOI: 10.1023/A:1022580929226

Prevention of tropical illness in older travellers: The older cruiser

Geriatrics and Aging

Penn, C. and Tan, R.

Optimization of epicutaneous immunization for the induction of CTL

Vaccine

Kahlon, R. and Hu, Y. and Orteu, C.H. and Kifayet, A. and Trudeau, J.D. and Tan, R. and Dutz, J.P.

DOI: 10.1016/S0264-410X(03)00141-5

Establishment and comprehensive analysis of a new human transformed follicular lymphoma B cell line, Tat-1

Leukemia

T Denyssevych and V S Lestou and S Knesevich and M Robichaud and C Salski and R Tan and R D Gascoyne and D E Horsman and L D Mayer

DOI: 10.1038/sj.leu.2402372

02 / 2002

In situ cell death promotes priming of diabetogenic CD8 T lymphocytes

Journal of Immunology

Zhang, Y. and O'Brien, B. and Trudeau, J. and Tan, R. and Santamaria, P. and Dutz, J.P.

DOI: 10.4049/jimmunol.168.3.1466

Evaluation of a diagnostic polymerase chain reaction assay for Neisseria meningitidis in North America and field experience during an outbreak

Archives of Pathology and Laboratory Medicine

Pollard, A.J. and Probe, G. and Trombley, C. and Castell, A. and Whitehead, S. and Bigham, J.M. and Champagne, S. and Isaac-Renton, J. and Tan, R. and Guiver, M. and Borrow, R. and Speert, D.P. and Thomas, E.

Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase

Journal of Biological Chemistry

Aoukaty, A. and Tan, R.

DOI: 10.1074/jbc.M112029200

Expansion of the antigenic repertoire of a single T cell receptor upon T cell activation

Journal of Immunology

Amrani, A. and Serra, P. and Yamanouchi, J. and Trudeau, J.D. and Tan, R. and Elliott, J.F. and Santamaria, P.

DOI: 10.4049/jimmunol.167.2.655

Meningococcal Disease in British Columbia

BC Medical Journal

A. Pollard, J. Bigham, K. Bhachu, C. Shaw, J. Isaac-Renton, R. Tan, E. Thomas. Meningococcal Disease in British Columbia. 2001, B.C. Med. J. 43(1):21-27.

Manifestations of X-linked lymphoproliferative disease without prior Epstein-Barr virus exposure [2] (multiple letter)

Blood

Schuster, V. and Steppberger, K. and Borte, M. and Tan, R. and Dutz, J. and Benoit, L. and De Sa, D. and Junker, A.

DOI: 10.1182/blood.V98.6.1986

Lymphocytic vasculitis in X-linked lymphoproliferative disease

Blood

Dutz, J.P. and Benoit, L. and Wang, X. and Demetrick, D.J. and Junker, A. and De Sa, D. and Tan, R.

DOI: 10.1182/blood.V97.1.95

The expanding clinical phenotype of SAP/SH2D1A mutations

Blood

R. Tan, J. Dutz, L. Benoit, D. de Sa and A. Junker. The expanding clinical phenotype of SAP/SH2D1A mutations. Blood. 2001; 98:1986-1987.

Utilization of herpes simplex PCR assays for cerebrospinal fluid in a pediatric health care setting

Canadian Journal of Microbiology

Cimolai, N. and Thomas, E.E. and Tan, R. and Hill, A.

DOI: 10.1139/w01-028

Expansion of human cytotoxic T lymphocytes for immunotherapy

Lymphocytes: A Practical Approach (2nd edition)

R. Tan. Expansion of human cytotoxic T lymphocytes for immunotherapy. In: Lymphocytes: A Practical Approach (2nd edition), Rowland-Jones & McMichael (ed.), Oxford University Press, Oxford, 2000

Progression of autoimmune diabetes driven by avidity maturation of a T- cell population

Nature

Amranl, A. and Verdaguer, J. and Serra, P. and Tafuro, S. and Tan, R. and Santamaria, P.

DOI: 10.1038/35021081

Creating HIV-1 reverse transcriptase cytotoxic T lymphocyte target structures by HLA-A2 heavy chain modifications

International Immunology

Dela Cruz, C.S. and Tan, R. and Rowland-Jones, S.L. and Barber, B.H.

DOI: 10.1093/intimm/12.9.1293

Cutting edge: Defective NK cell activation in X-linked lymphoproliferative disease

Journal of Immunology

Benoit, L. and Wang, X. and Pabst, H.F. and Dutz, J. and Tan, R.

DOI: 10.4049/jimmunol.165.7.3549

Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome

Blood

Tan, R. and Xu, X. and Ogg, G.S. and Hansasuta, P. and Dong, T. and Rostron, T. and Luzzi, G. and Conlon, C.P. and Screaton, G.R. and McMichael, A.J. and Rowland-Jones, S.

DOI: 10.1182/blood.v93.5.1506.405a38_1506_1510

Case-Control Study of Primary Human Herpesvirus 6Infection in Children With Febrile Seizures

PEDIATRICS

J. Hukin and K. Farrell and L. M MacWilliam and M. Colbourne and E. Waida and R. Tan and L. Mroz and E. Thomas

DOI: 10.1542/peds.101.2.e3

02 / 1998

Antigen-specific release of -chemokines by anti-HIV-1 cytotoxic T lymphocytes

Current Biology

Price, D.A. and Sewell, A.K. and Dong, T. and Tan, R. and Goulder, P.J.R. and Rowland-Jones, S.L. and Phillips, R.E.

DOI: 10.1016/s0960-9822(98)70138-1

Prolonged CD8+ T-cell expansions after adoptive transfer of syngeneic lymphocytes between HIV-discordant identical twins [10]

AIDS

Tan, R. and Wilson, J.D. and Rostron, T. and Peto, T. and McMichael, A.J. and Rowland-Jones, S.L.

Prolonged CD8+ T-cell expansions after adoptive transfer of syngeneic lymphocytes to a patient with AIDS

AIDS

R. Tan, J.D. Wilson, T. Rostron, T. Peto, A.J. McMichael and S. Rowland-Jones. Prolonged CD8+ T-cell expansions after adoptive transfer of syngeneic lymphocytes to a patient with AIDS. 1998 AIDS 12:2240-2241.

PubMed: 9833875

Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice

Journal of General Virology

Hanke, T. and Blanchard, T.J. and Schneider, J. and Ogg, G.S. and Tan, R. and Becker, M. and Gilbert, S.C. and Hill, A.V.S. and Smith, G.L. and McMichael, A.

DOI: 10.1099/0022-1317-79-1-83

Role of cellular immunity in protection against HIV infection

Advances in Immunology

Rowland-Jones, S. and Tan, R. and McMichael, A.

LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing

Proceedings of the National Academy of Sciences of the United States of America

Screaton, G.R. and Xu, X.-N. and Olsen, A.L. and Cowper, A.E. and Tan, R. and Mcmichael, A.J. and Bell, J.I.

DOI: 10.1073/pnas.94.9.4615

Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus- infected cells

Journal of Experimental Medicine

Xu, X.-N. and Screaton, G.R. and Gotch, F.M. and Dong, T. and Tan, R. and Almond, N. and Walker, B. and Stebbings, R. and Kent, K. and Nagata, S. and Stott, J.E. and McMichael, A.J.

DOI: 10.1084/jem.186.1.7

Immunology of HIV infection

Molecular Medicine Today

Tan, R.

DOI: 10.1016/S1357-4310(97)01063-0

Control of hiv co-receptor expression: Implications for pathogenesis and treatment

Trends in Microbiology

Rowland-Jones, S. and Tan, R.

DOI: 10.1016/S0966-842X(97)01092-5

Immunizations for travel to tropical and developing countries

BC Medical Journal

R. Tan Immunizations for travel to tropical and developing countries. 1994. British Columbia Medical Journal 36:248-251.

The Four "Is"

Journal of Travel Medicine

R. Tan The Four "Is" (letter). 1994. J Trav Med. 1(4):238.

Postoperative endophthalmitis caused by stomatococcus mucilaginosus

Clinical Infectious Diseases

Tan, R. and White, V. and Servais, G. and Bryce, E.A.

DOI: 10.1093/clinids/18.3.492

Sharps utilization and disposal in British Columbia physicians offices

Canadian Journal of Public Health

R. Tan, and M. Noble. Sharps utilization and disposal in British Columbia physicians offices. 1993 Canadian Journal of Public Health 84:31-4.

PubMed: 8500054

B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes.

The Journal of Immunology

Tan, R and Teh, S J and Ledbetter, J A and Linsley, P S and Teh, H S

Guidelines for HIV screening

BC Medical Journal

R. Tan and M. Noble. Guidelines for HIV screening. 1992. British Columbia Medical Journal 33:587.

B7 costimulates proliferation of CD4^-8⁺ T lymphocytes but is not required for the deletion of immature CD4⁺8⁺ thymocytes

Journal of Immunology

Tan, R. and Teh, S.-J. and Ledbetter, J.A. and Linsley, P.S. and Teh, H.-S.

Medical microbiology, virology and infection control (clinical)

The medical microbiology laboratory in the Department of Pathology & Laboratory Medicine at BC Children's Hospital (BCCH) is a leader in the development of molecular diagnostic assays for pediatric infectious diseases. For example, molecular assays have been developed for human herpesvirus 6 (HHV-6), enteroviruses and Epstein-Barr virus, for the diagnosis and typing of Neisseria meningitidis (meningococcus) and for novel agents such as human metapneumovirus. The laboratory is continually adapting and developing new real-time (Taqman) and rapid Smart Cycler PCR diagnostics for a variety of bacterial and viral pathogens. In addition, the laboratory is engaged in changing the primary care management of common respiratory illnesses by providing a VIral RAPid testing program (VIRAP) that allows for the rapid (less than 4 hour) diagnosis of common respiratory pathogens.

Autoimmunity in type 1 diabetes

Type 1 (juvenile-onset) diabetes mellitus arises from a T-cell-mediated autoimmune process directed against pancreatic beta cells in both humans and non-obese diabetic (NOD) mice. The destruction of beta cells is mediated by CD8+ cytotoxic T lymphocytes (CTL). Using MHC Class 1 tetrameric complexes to detect and determine the frequency of autoreactive CTL in NOD mice we have developed a predictive algorithm for disease. In collaboration with Drs. Bruce Verchere and Dina Panagiotopoulos we are hoping to extend these findings to humans through the identification of human MHC class I restricted epitopes. The laboratory is also studying several different areas of the pathogenesis of type 1 diabetes including the role of autoreactive CTL and the role of natural killer cells.

X-linked lymphoproliferative disease

We have cloned and sequenced a novel mutation in the gene responsible for the fatal childhood disease, X-linked lymphoproliferative disease (XLP), thus resolving a longstanding mystery of unexplained male deaths in a large aboriginal family from northern Canada. The presence of the mutation in this extended family allows us to study the specific role of the lymphocyte cell protein, SLAM-associated protein (SAP) in human immunity to viruses and tumours. In particular, we are investigating the role of SAP in the cellular and molecular dysfunction of cytotoxic T lymphocytes and natural killer cells and the relationship between these abnormalities and the clinical phenotype of disease.

Honours & Awards

Most Valuable Player, Department of Pathology & Laboratory Medicine, University of British Columbia - 2009

Michael Smith Foundation Senior Scholar 2006-

Green College Faculty Member, 2005-

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Rusung Tan

MD, FRCPC, PhD

Investigator Emeritus, BC Children's Hospital

Academic Affiliations

Contact Information

Publications

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A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes

Virome-wide serological profiling reveals association of herpesviruses with obesity

A metagenomics-based diagnostic approach for central nervous system infections in hospital acute care setting

Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: A case report

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis

A novel real-time PCR assay panel for detection of common respiratory pathogens in a convenient, strip-tube array format

A Metagenomics " Based Diagnostic Approach for Central Nervous System Infections in Hospital Acute Care Setting

Treg gene signatures predict and measure type 1 diabetes trajectory

Profiling of circulating microRNAs in children with recent onset of type 1 diabetes

Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+ IL-17+ cells

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression

Comparative evaluation of laboratory developed real-time PCR assays and RealStar BKV PCR Kit for quantitative detection of BK polyomavirus

Depletion of human DNA in spiked clinical specimens for improvement of sensitivity of pathogen detection by next-generation sequencing

Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis

Nocardia asteroides sinusitis in a pediatric patient: Case report with 20 year follow-up and review of the literature

CCL22 prevents rejection of mouse islet allografts and induces donor-specific tolerance

CD1d expression and invariant NKT cell responses in herpesvirus infections

Natural killer T cell strategies to combat Epstein-Barr virus infection

Combined immunodeficiency associated with homozygous MALT1 mutations

Evaluation of amplification targets for the specific detection of Bordetella pertussis using real-time polymerase chain reaction

Insulin-producing intestinal K cells protect nonobese diabetic mice from autoimmune diabetes

SLAM-SAP signaling promotes differentiation of IL-17-producing T cells and progression of experimental autoimmune encephalomyelitis

Innate immune control of EBV-infected B cells by invariant natural killer T cells

Optimal use of MRSASelect and PCR to maximize sensitivity and specificity of MRSA detection

Amino acid structure determines the immune responses generated by peptide-gold nanoparticle hybrids

PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS)

Decidual NK Cell-Derived Conditioned Medium (dNK-CM) Mediates VEGF-C Secretion in Extravillous Cytotrophoblasts

Short-term stability of pathogen-specific nucleic acid targets in clinical samples

NKT cells are required for complete freund's adjuvant-mediated protection from autoimmune diabetes

The CaV1.4 Calcium Channel Is a Critical Regulator of T Cell Receptor Signaling and Naive T Cell Homeostasis

CD1d and CD1c expression in human B cells is regulated by activation and retinoic acid receptor signaling

The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling

Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes

RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells

Decidual NK cell-derived conditioned medium enhances capillary tube and network organization in an extravillous cytotrophoblast cell line

Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells

Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency

Critical role for IFN- in natural killer cell-mediated protection from diabetes

The X-linked lymphoproliferative syndrome gene product SAP regulates B cell function through the FcRIIB receptor

IFN--mediated extravillous trophoblast outgrowth inhibition in first trimester explant culture: A role for insulin-like growth factors

Xenogeneic 2-microglobulin substitution alters NK cell function

Xenogeneic 2-microglobulin substitution affects functional binding of MHC class I molecules by CD8+ T cells

Prospective prediction of spontaneous but not recurrent autoimmune diabetes in the non-obese diabetic mouse

Recognition of HLA class I-restricted -cell epitopes in type 1 diabetes

Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: A role for IFN-

Identification of novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives

Cutting edge: Signaling lymphocytic activation molecule-associated protein controls NKT cell functions

The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts

Current approaches for the prediction and identification of CD8 T-cell epitopes in type 1 diabetes

Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease

Detection and enumeration of beta cell-specific cytotoxic T lymphocytes in type 1 diabetes: Is disease prediction possible?

Current approaches for the prediction and identification of CD8 T cell epitopes in type 1 diabetes

Rapid and fatal meningococcal disease due to a strain of Neisseria meningitidis containing the capsule null locus.

Murine CD160, Ig-like receptor on NK Cells and NKT cells, recognizes classical and nonclassical MHC class I and regulates NK cell activation

Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL

Regulation of Autoimmune Diabetes by Complete Freund's Adjuvant Is Mediated by NK Cells

Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR

T-cell epitopes in type 1 diabetes

Molecular dissection of 2B4 signaling: Implications for signal transduction by SLAM-related receptors

Identification of a -Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

Preventing tropical illness in elderly travellers: the older cruiser

Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells

Prevention of tropical illness in older travellers: The older cruiser

Optimization of epicutaneous immunization for the induction of CTL

Establishment and comprehensive analysis of a new human transformed follicular lymphoma B cell line, Tat-1

In situ cell death promotes priming of diabetogenic CD8 T lymphocytes

Evaluation of a diagnostic polymerase chain reaction assay for Neisseria meningitidis in North America and field experience during an outbreak

Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase

Expansion of the antigenic repertoire of a single T cell receptor upon T cell activation

Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3⁺ IL-17⁺ cells

B7 costimulates proliferation of CD4^-8⁺ T lymphocytes but is not required for the deletion of immature CD4⁺8⁺ thymocytes