Jonathan Rayment

MDCM, FRCPC, MSc

Investigator, BC Children's Hospital

I am interested in the development of new tools that will help us detect lung disease in children. Specifically, this includes new, more sensitive breathing tests that will help us measure lung function in children. As well, I am interested in developing new imaging tests (such as MRI) that will help us see the structure of the lung.

My research focuses primarily, but not exclusively, on patients with cystic fibrosis.

Academic Affiliations

  • Clinical Associate Professor, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases
  • Research Group(s): Clinical Practice, Outcomes and Innovation; Rare Diseases

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

Utility of hyperpolarised xenon-129 magnetic resonance imaging in primary ciliary dyskinesia

ERJ Open Research

Wallace B. Wee and Brandon Zanette and Samal Munidasa and Rachel L. Eddy and Jonathan H. Rayment and Teresa To and Felix Ratjen and Giles Santyr and Sharon D. Dell

DOI: 10.1183/23120541.01105-2025

03 / 2026

Heterogeneity of short-term elexacaftor-tezacaftor-ivacaftor response in cystic fibrosis using 129Xe MRI

Thorax

Rachel L Eddy and Vanessa M Diamond and Josie Chrenek and Girija Bhatnagar and David Sag and Rana Ghadymimahani and Amreen Aulakh and Britney X Ha and Bradley S Quon and Jonathan H Rayment

DOI: 10.1136/thorax-2025-223687

12 / 2025

Home Microbiological Sampling in a Pediatric Cystic Fibrosis Population: Pandemic Implementation and Ongoing Use

Pediatric Pulmonology

Valerie Swanston and Jeffrey N. Bone and Melissa Richmond and David Goldfarb and Jonathan H. Rayment

DOI: 10.1002/ppul.71378

11 / 2025

Monitoring for paediatric pulmonary graft versus host disease with multiple breath washout

ERJ Open Research

Britney X. Ha and Juliana P. Roden and Rodrigo A. Sandoval and Kirk R. Schultz and Jonathan H. Rayment

DOI: 10.1183/23120541.00015-2025

09 / 2025

The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: Protocol for a prospective, observational cohort study

BMJ Open

Burns, P. and Eddy, R.L. and Li, X. and Yang, J. and Dhillon, S.S. and Couillard, S. and Stickland, M.K. and Guenette, J. and Svenningsen, S. and Tulloch, T. and Samji, H. and Meza, R. and Struik, L.L. and Aaron, S. and Ho, T. and Lam, S. and Leipsic, J. and MacLean, J. and Afshar, T. and Moraes, T.J. and Zanette, B. and Santyr, G. and Counil, F.-P. and Hernandez Cordero, A.I. and Matano, S. and De Arruda Maluf, G. and Leung, C. and Feng, C. and Bal, L. and Dhaliwal, H. and Mumuni, A. and Lui, C. and Drew, H. and Sin, D.D. and Rayment, J.H. and Leung, J.M.

DOI: 10.1136/bmjopen-2025-100568

Repeatability of Multiple Breath Washout in Pediatric Primary Ciliary Dyskinesia

Pediatric Pulmonology

Wee, W.B. and Bashi, L.M. and Jensen, R. and Rayment, J.H. and To, T. and Ratjen, F. and Santyr, G. and Dell, S.D.

DOI: 10.1002/ppul.71107

Pulmonary 129Xe MRI: CNN Registration and Segmentation to Generate Ventilation Defect Percent with Multi-center Validation

Academic Radiology

Mozaffaripour, A. and Matheson, A.M. and Rahman, O. and Sharma, M. and Kooner, H.K. and McIntosh, M.J. and Rayment, J. and Eddy, R.L. and Svenningsen, S. and Parraga, G.

DOI: 10.1016/j.acra.2024.10.029

Hyperpolarized129XE MRI and Spectroscopy: Quantitative Measurements, Results, and Emerging Opportunities

Radiology Cardiothoracic Imaging

Schmidt, A. and Liggins, J.A. and Bhutta, H. and Dell, S.D. and Leung, J.M. and Sin, D.D. and Leipsic, J.A. and Rayment, J.H. and Eddy, R.L.

DOI: 10.1148/ryct.240562

A multimorphic variant in ThPOK causes an inborn error of immunity with T cell defects and fibrosis

Journal of Experimental Medicine

Vaseghi-Shanjani, M. and Sharma, M. and Yousefi, P. and Samra, S. and Laverty, K.U. and Jolma, A. and Razavi, R. and Yang, A.H.W. and Albu, M. and Golding, L. and Lee, A.F. and Tan, R. and Richmond, P.A. and Bosticardo, M. and Rayment, J.H. and Yang, C.L. and Hildebrand, K.J. and Brager, R. and Demos, M.K. and Lau, Y.-L. and Notarangelo, L.D. and Hughes, T.R. and Biggs, C.M. and Turvey, S.E.

DOI: 10.1084/jem.20241174

Three-Dimensional Free-Breathing Ultrashort Echo Time (UTE) 1H MRI Regional Ventilation: Comparison With Hyperpolarized 129Xe MRI and Pulmonary Function Testing in Healthy Volunteers and People With Cystic Fibrosis

NMR in Biomedicine

Tan, F. and Eddy, R. and Diamond, V. and Rayment, J. and Larson, P.

DOI: 10.1002/nbm.70033

Risk Factors for Severe Disease Among Children Hospitalized With Respiratory Syncytial Virus

JAMA Network Open

Kirolos, N. and Mtaweh, H. and Datta, R.R. and Farrar, D.S. and Seaton, C. and Bone, J.N. and Muttalib, F. and Kaziev, C.L. and Fortini, J. and Mahant, S. and Campigotto, A. and Freire, G. and Yeung, R.S.M. and Rayment, J.H. and Yang, C. and Srigley, J.A. and Sadarangani, M. and Buchanan, F. and Morris, S.K. and Gill, P.J.

DOI: 10.1001/jamanetworkopen.2025.4666

A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging

Journal of Magnetic Resonance Imaging

Diamond, V.M. and Bell, L.C. and Bone, J.N. and Driehuys, B. and Menchaca, M. and Santyr, G. and Svenningsen, S. and Thomen, R.P. and Marshall, H. and Smith, L.J. and Collier, G.J. and Wild, J.M. and Woods, J.C. and Fain, S.B. and Eddy, R.L. and Rayment, J.H.

DOI: 10.1002/jmri.29746

Maximising opportunity for therapeutic success: sequential participation in cystic fibrosis nucleic acid-based therapy trials

Lancet Respiratory Medicine

Mayer-Hamblett, N. and Kerper, N.R. and Clancy, J.P. and Davies, J.C. and Taylor-Cousar, J.L. and Donaldson, S.H. and Bell, S.C. and Jain, R. and Simmonds, N.J. and Mall, M.A. and Goss, C.H. and Rayment, J.H. and Setiawan, L. and Pilewski, J.M.

DOI: 10.1016/S2213-2600(25)00206-1

Long-Term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Children >6 Years with Cystic Fibrosis and at Least One F508del Allele: A 192-Week, Phase 3, Open-Label Extension Study

American Journal of Respiratory and Critical Care Medicine

Wainwright, C. and McColley, S.A. and McNally, P. and Powers, M. and Ratjen, F. and Rayment, J.H. and Retsch-Bogart, G. and Roesch, E. and Ramsey, B. and McKone, E.F. and Tullis, E. and Mall, M.A. and Taylor-Cousar, J.L. and Waltz, D. and Ahluwalia, N. and Chu, C. and Scirica, C.V. and Davies, J.C.

DOI: 10.1164/rccm.202502-0512OC

Corrigendum to Diagnosis of post-hematopoietic stem cell transplant bronchiolitis obliterans syndrome in children: time for a rethink? Transplantation and Cellular Therapy. 2024 Aug;30(8):760-769 (Transplantation and Cellular Therapy (2024) 30(8) (760"769), (S2666636724004111), (10.1016/j.jtct.2024.05.012))

Transplantation and Cellular Therapy

Shanthikumar, S. and Gower, W.A. and Cooke, K.R. and Bergeron, A. and Schultz, K.R. and Barochia, A. and Tamae-Kakazu, M. and Charbek, E. and Reardon, E.E. and Calvo, C. and Casey, A. and Cheng, P.C. and Cole, T.S. and Davies, S.M. and Das, S. and De, A. and Deterding, R.R. and Liptzin, D.R. and Mechinaud, F. and Rayment, J.H. and Robinson, P.D. and Siddiah, R. and Stone, A. and Srinivasin, S. and Towe, C.T. and Yanik, G.A. and Iyer, N.P. and Goldfarb, S.B.

DOI: 10.1016/j.jtct.2025.05.009

A multimorphic variant in ThPOK causes a novel human disease characterized by T cell abnormalities, immunodysregulation, allergy, and fibrosis

medRxiv

Vaseghi-Shanjani, M. and Sharma, M. and Yousefi, P. and Samra, S. and Laverty, K.U. and Jolma, A. and Razavi, R. and Yang, A.H.W. and Albu, M. and Golding, L. and Lee, A.F. and Tan, R. and Richmond, P.A. and Bosticardo, M. and Rayment, J.H. and Yang, C.L. and Hildebrand, K.J. and Brager, R. and Demos, M.K. and Lau, Y.L. and Notarangelo, L.D. and Hughes, T.R. and Biggs, C.M. and Turvey, S.E.

DOI: 10.1101/2024.06.26.24309360

Diagnosis of Post-Hematopoietic Stem Cell Transplantation Bronchiolitis Obliterans Syndrome in Children: Time for a Rethink?

Transplantation and Cellular Therapy

Shanthikumar, S. and Gower, W.A. and Cooke, K.R. and Bergeron, A. and Schultz, K.R. and Barochia, A. and Tamae-Kakazu, M. and Charbek, E. and Reardon, E.E. and Calvo, C. and Casey, A. and Cheng, P.C. and Cole, T.S. and Davies, S.M. and Das, S. and De, A. and Deterding, R.R. and Liptzin, D.R. and Mechinaud, F. and Rayment, J.H. and Robinson, P.D. and Siddaiah, R. and Stone, A. and Srinivasin, S. and Towe, C.T. and Yanik, G.A. and Iyer, N.P. and Goldfarb, S.B.

DOI: 10.1016/j.jtct.2024.05.012

Detection of Bronchiolitis Obliterans Syndrome after Pediatric Hematopoietic Stem Cell Transplantation An Official American Thoracic Society Clinical Practice Guideline

American Journal of Respiratory and Critical Care Medicine

Shanthikumar, S. and Goldfarb, S. and Abts, M. and Barochia, A. and Bergeron, A. and Blinman, T. and Bracken, J. and Calvo, C. and Casey, A. and Charbek, E. and Cheng, P.C. and Cole, T.S. and Cooke, K.R. and Das, S. and Davies, S.M. and De, A. and Deterding, R.R. and Gower, W.A. and Gross, J. and Iyer, N.P. and Liptzin, D.R. and Mechinaud, F. and Rayment, J.H. and Reardon, E.E. and Robinson, P.D. and Schultz, K.R. and Sheshadri, A. and Siddaiah, R. and Srinivasan, S. and Stone, A. and Tamae-Kakazu, M. and Teusink-Cross, A. and Towe, C.T. and Walkup, L.L. and Yanik, G.A.

DOI: 10.1164/rccm.202406-1117ST

Frequent microbiological surveillance during inpatient cystic fibrosis pulmonary exacerbations has limited clinical value: Respiratory culture monitoring during exacerbation

Journal of Cystic Fibrosis

Song, W.H. and Wong, K.S. and Goldfarb, D.M. and Bone, J.N. and Rayment, J.H.

DOI: 10.1016/j.jcf.2023.10.007

Emergence of the natural history of Myhre syndrome: 47 patients evaluated in the Massachusetts General Hospital Myhre Syndrome Clinic (2016"2023)

American Journal of Medical Genetics, Part A

Lin, A.E. and Scimone, E.R. and Thom, R.P. and Balaguru, D. and Kinane, T.B. and Moschovis, P.P. and Cohen, M.S. and Tan, W. and Hague, C.D. and Dannheim, K. and Levitsky, L.L. and Lilly, E. and DiGiacomo, D.V. and Masse, K.M. and Kadzielski, S.M. and Zar-Kessler, C.A. and Ginns, L.C. and Neumeyer, A.M. and Colvin, M.K. and Elder, J.S. and Learn, C.P. and Mou, H. and Weagle, K.M. and Buch, K.A. and Butler, W.E. and Alhadid, K. and Musolino, P.L. and Sultana, S. and Bandyopadhyay, D. and Rapalino, O. and Peacock, Z.S. and Chou, E.L. and Heidary, G. and Dorfman, A.T. and Morris, S.A. and Bergin, J.D. and Rayment, J.H. and Schimmenti, L.A. and Lindsay, M.E.

DOI: 10.1002/ajmg.a.63638

A randomised trial of oral prednisone for cystic fibrosis pulmonary exacerbation treatment

European Respiratory Journal

Waters, V. and Shaw, M. and Perrem, L. and Quon, B.S. and Tullis, E. and Solomon, M. and Rayment, J.H. and Lavoie, A. and Tse, S.M. and Daigneault, P. and Bilodeau, L. and Price, A. and Nicholson, M. and Chin, M. and Parkins, M. and McKinney, M.L. and Tam, J.S. and Stanojevic, S. and Grasemann, H. and Ratjen, F.

DOI: 10.1183/13993003.02278-2023

Advancing the pipeline of cystic fibrosis clinical trials: a new roadmap with a global trial network perspective

The Lancet Respiratory Medicine

Mayer-Hamblett, N. and Clancy, J.P. and Jain, R. and Donaldson, S.H. and Fajac, I. and Goss, C.H. and Polineni, D. and Ratjen, F. and Quon, B.S. and Zemanick, E.T. and Bell, S.C. and Davies, J.C. and Jain, M. and Konstan, M.W. and Kerper, N.R. and LaRosa, T. and Mall, M.A. and McKone, E. and Pearson, K. and Pilewski, J.M. and Quittell, L. and Rayment, J.H. and Rowe, S.M. and Taylor-Cousar, J.L. and Retsch-Bogart, G. and Downey, D.G.

DOI: 10.1016/S2213-2600(23)00297-7

Multiple breath washout and oscillometry after allogenic HSCT: a scoping review

European Respiratory Review

Sonneveld, N. and Rayment, J.H. and Robinson, P.D. and Usemann, J. and Nielsen, K.G.

DOI: 10.1183/16000617.0251-2022

Long-Term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Children Aged >6 Years with Cystic Fibrosis and at Least One F508del Allele A Phase 3, Open-Label Clinical Trial

American Journal of Respiratory and Critical Care Medicine

Wainwright, C. and McColley, S.A. and McNally, P. and Powers, M. and Ratjen, F. and Rayment, J.H. and Retsch-Bogart, G. and Roesch, E. and Ahluwalia, N. and Chin, A. and Chu, C. and Lu, M. and Menon, P. and Waltz, D. and Weinstock, T. and Zelazoski, L. and Davies, J.C.

DOI: 10.1164/rccm.202301-0021OC

Genetics of bronchopulmonary dysplasia: An update

Seminars in Perinatology

Lavoie, P.M. and Rayment, J.H.

DOI: 10.1016/j.semperi.2023.151811

Phase 3 Open-Label Clinical Trial of Elexacaftor/Tezacaftor/Ivacaftor in Children Aged 2"5 Years with Cystic Fibrosis and at Least One F508del Allele

American Journal of Respiratory and Critical Care Medicine

Goralski, J.L. and Hoppe, J.E. and Mall, M.A. and McColley, S.A. and McKone, E. and Ramsey, B. and Rayment, J.H. and Robinson, P. and Stehling, F. and Taylor-Cousar, J.L. and Tullis, E. and Ahluwalia, N. and Chin, A. and Chu, C. and Lu, M. and Niu, T. and Weinstock, T. and Ratjen, F. and Rosenfeld, M.

DOI: 10.1164/rccm.202301-0084OC

Heterogenous Disease Course and Long-Term Outcome of Childrens Interstitial Lung Disease Related to Filamin A Gene Variants

Annals of the American Thoracic Society

Julia Carlens and K. Taneille Johnson and Andrew Bush and Diane Renz and Ute Hehr and Florian Laenger and Claire Hogg and Martin Wetzke and Nicolaus Schwerk and Jonathan H. Rayment

DOI: 10.1513/AnnalsATS.202202-142OC

12 / 2022

A Phase 3, Open-Label Study of Lumacaftor/Ivacaftor in Children 1 to Less Than 2 Years of Age with Cystic Fibrosis Homozygous for F508del-CFTR

American Journal of Respiratory and Critical Care Medicine

Jonathan H. Rayment and Fadi Asfour and Margaret Rosenfeld and Mark Higgins and Lingyun Liu and Molly Mascia and Hildegarde Paz-Diaz and Simon Tian and Rachel Zahigian and Susanna A. McColley

DOI: 10.1164/rccm.202204-0734OC

11 / 2022

CFTR modulators increase risk of acute pancreatitis in pancreatic insufficient patients with cystic fibrosis

Journal of Cystic Fibrosis

Michelle J. Gould and Haley Smith and Jonathan H Rayment and Helen Machida and Tanja Gonska and Gary J. Galante

DOI: 10.1016/j.jcf.2021.09.010

07 / 2022

Multiple Breath Washout Testing to Identify Pulmonary Chronic Graft Versus Host Disease in Children After Hematopoietic Stem Cell Transplantation

Transplantation and Cellular Therapy

Jonathan H. Rayment and Rodrigo A. Sandoval and Juliana P. Roden and Kirk R. Schultz

DOI: 10.1016/j.jtct.2022.02.002

06 / 2022

Pulmonary functional MRI: Detecting the structure"function pathologies that drive asthma symptoms and quality of life

Respirology

Kooner, H.K. and McIntosh, M.J. and Desaigoudar, V. and Rayment, J.H. and Eddy, R.L. and Driehuys, B. and Parraga, G.

DOI: 10.1111/resp.14197

All hands on deck: A multidisciplinary approach to SARS-CoV-2-associated MIS-C

Paediatrics and Child Health (Canada)

Lopez, A.A. and Patel, M. and Rayment, J.H. and Tam, H. and Roberts, A. and Laskin, S. and Tucker, L. and Biggs, C.M. and Ahmed, M.A. and Barakauskas, V. and Galanis, E. and Goldfarb, D. and Halparin, J. and Harris, K.C. and Kissoon, N. and Lawrence, S. and McGuffin, D. and Meckler, G. and Noel, K. and Schrader, D. and Sherwood, M. and Singh, A. and Vercauteren, S.

DOI: 10.1093/pch/pxab110

The effect of inhaled hypertonic saline on lung structure in children aged 3"6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial

The Lancet Respiratory Medicine

Tiddens, H.A.W.M. and Chen, Y. and Andrinopoulou, E.-R. and Davis, S.D. and Rosenfeld, M. and Ratjen, F. and Kronmal, R.A. and Hinckley Stukovsky, K.D. and Dasiewicz, A. and Stick, S.M. and Anthony, M.M. and Au, J. and Belessis, Y. and Bonte, M. and Cheney, J. and Clem, C. and Clements, B. and Cooper, P. and Davis, S.D. and Davis, M. and de Boeck, K. and de Marchis, M. and De Wachter, E. and Delaisi, B. and Delaup, V. and DeRicco, A. and Foti, A. and Gan, R. and Garriga, L. and Gartner, S. and Genatossio, A. and Grogan, S. and Hilton, J. and Hoppe, J.E. and Janssens, H.M. and Jensen, R. and Johnson, R. and Kemner-van de Corput, M.P.C. and Klein, B. and Kronmal, R.A. and Lucca, F. and Lucidi, V. and Montemitro, E. and Nahidi, L. and Nielsen, K.G. and Pearce, K. and Pittman, J.E. and Powers, M. and Prentice, C. and Pressler, T. and Rayment, J.H. and Reix, P. and Retsch-Bogart, G. and Riera, L. and Robinson, P. and Robinson, P. and Sanders, D.B. and Sandoval, R.A. and Sandvik, R.M. and Saunders, C. and Siegel, M. and Smith, J. and Solomon, M. and Stanojevic, S. and Tai, A. and Tiddens, H.A.W.M. and van de Puttelaar, J. and Van den Brande, C. and van Straten, M. and Vermeulen, F. and Volpi, S. and Wainwright, C.E. and Weiner, D.J. and Yuan, Y. and Zaimeddine, S.

DOI: 10.1016/S2213-2600(21)00546-4

All hands on deck: A multidisciplinary approach to SARS-CoV-2-associated MIS-C,Tout le monde sur le pont: une approche multidisciplinaire du SRAS-CoV-2 associe au SIME

Paediatrics and Child Health (Canada)

Lopez, A.A. and Patel, M. and Rayment, J.H. and Tam, H. and Roberts, A. and Laskin, S. and Ahmed, M.A. and Barakauskas, V. and Galanis, E. and Goldfarb, D. and Halparin, J. and Harris, K.C. and Kissoon, N. and Lawrence, S. and Mcguffin, D. and Meckler, G. and Noel, K. and Schrader, D. and Sherwood, M. and Singh, A. and Vercauteren, S. and Tucker, L. and Biggs, C.M.

DOI: 10.1093/pch/pxac018

Diffuse alveolar haemorrhage in a child with trisomy 21

Journal of Paediatrics and Child Health

Susan Telencoe and Ajay C Kevat and Anna F Lee and Jonathan H Rayment

DOI: 10.1111/jpc.15331

10 / 2021

A phase 3 open-label study of elexacaftor/tezacaftor/ivacaftor in children 6 through 11 years of age with cystic fibrosis and at least one F508del allele

American Journal of Respiratory and Critical Care Medicine

Zemanick, E.T. and Taylor-Cousar, J.L. and Davies, J. and Gibson, R.L. and Mall, M.A. and McKone, E.F. and McNally, P. and Ramsey, B.W. and Rayment, J.H. and Rowe, S.M. and Tullis, E. and Ahluwalia, N. and Chu, C. and Ho, T. and Moskowitz, S.M. and Noel, S. and Tian, S. and Waltz, D. and Weinstock, T.G. and Xuan, F. and Wainwright, C.E. and McColley, S.A.

DOI: 10.1164/rccm.202102-0509OC

Protocols for multi-site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium

Magnetic Resonance in Medicine

Niedbalski, P.J. and Hall, C.S. and Castro, M. and Eddy, R.L. and Rayment, J.H. and Svenningsen, S. and Parraga, G. and Zanette, B. and Santyr, G.E. and Thomen, R.P. and Stewart, N.J. and Collier, G.J. and Chan, H.-F. and Wild, J.M. and Fain, S.B. and Miller, G.W. and Mata, J.F. and Mugler, J.P. and Driehuys, B. and Willmering, M.M. and Cleveland, Z.I. and Woods, J.C.

DOI: 10.1002/mrm.28985

Comparison of Functional Free-Breathing Pulmonary 1H and Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Cystic Fibrosis

Academic Radiology

Couch, M.J. and Munidasa, S. and Rayment, J.H. and Voskrebenzev, A. and Seethamraju, R.T. and Vogel-Claussen, J. and Ratjen, F. and Santyr, G.

DOI: 10.1016/j.acra.2020.05.008

Free-breathing MRI for Monitoring Ventilation Changes following Antibiotic Treatment of Pulmonary Exacerbations in Pediatric Cystic Fibrosis.

The European respiratory journal

Munidasa S and Couch MJ and Rayment JH and Voskrebenzev A and Seethamraju R and Vogel-Claussen J and Ratjen F and Santyr G

DOI: 10.1183/13993003.03104-2020 PubMed: 33303537

12 / 2020

Editorial for "Flow Volume Loop and Regional Ventilation Assessment Using Phase Resolved Functional Lung (PREFUL) MRI: Comparison With 129Xenon Ventilation MRI and Lung Function Testing".

Journal of magnetic resonance imaging : JMRI

Eddy RL and Rayment JH

DOI: 10.1002/jmri.27462 PubMed: 33314368

12 / 2020

Factors influencing clinical trial participation for adult and pediatric patients with cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Lee M and Hu XY and Desai S and Kwong E and Fu J and Flores E and Lazosky L and Wilcox PG and Mcllwaine M and Chilvers M and Yang C and Rayment JH and Quon BS

DOI: 10.1016/j.jcf.2020.08.019 PubMed: 32900673

09 / 2020

Sustained recovery of exocrine pancreatic function in a teenager with cystic fibrosis treated with ivacaftor

Pediatric Pulmonology

Smith, H. and Rayment, J.H.

DOI: 10.1002/ppul.24952

Assessing the feasibility of hyperpolarized 129Xe multiple-breath washout MRI in pediatric cystic fibrosis

Magnetic Resonance in Medicine

Couch, M.J. and Morgado, F. and Kanhere, N. and Kowalik, K. and Rayment, J.H. and Ratjen, F. and Santyr, G.

DOI: 10.1002/mrm.28099

Prolidase deficiency diagnosed by wholeexome sequencing in a child withpulmonary capillaritis

ERJ Open Research

DOI: 10.1183/23120541.00205-2018

04 / 2019

Hyperpolarised 129Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis

European Respiratory Journal

Rayment, J.H. and Couch, M.J. and McDonald, N. and Kanhere, N. and Manson, D. and Santyr, G. and Ratjen, F.

DOI: 10.1183/13993003.02188-2018

Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease

Academic Radiology

Santyr, G. and Kanhere, N. and Morgado, F. and Rayment, J.H. and Ratjen, F. and Couch, M.J.

DOI: 10.1016/j.acra.2018.04.024

An investigation into biomarkers for the diagnosis of ABPA and aspergillus disease in cystic fibrosis

Pediatric Pulmonology

Keown, K. and Abbott, S. and Kuzeljevic, B. and Rayment, J.H. and Chilvers, M.A. and Yang, C.L.

DOI: 10.1002/ppul.24465

Reply to Verbanck and Vanderhelst

American Journal of Respiratory and Critical Care Medicine

Kanhere, N. and Couch, M.J. and Rayment, J.H. and Ratjen, F. and Santyr, G.

DOI: 10.1164/rccm.201707-1392LE

The lung clearance index as a monitoring tool in cystic fibrosis: Ready for the clinic?

Current Opinion in Pulmonary Medicine

Perrem, L. and Rayment, J.H. and Ratjen, F.

DOI: 10.1097/MCP.0000000000000515

Lung clearance index to monitor treatment response in pulmonary exacerbations in preschool children with cystic fibrosis

Thorax

Rayment, J.H. and Stanojevic, S. and Davis, S.D. and Retsch-Bogart, G. and Ratjen, F.

DOI: 10.1136/thoraxjnl-2017-210979

Back to the source " Modern insights into pulmonary exacerbations and lung function decline from CF registry data

Journal of Cystic Fibrosis

Rayment, J.H. and Quon, B.S.

DOI: 10.1016/j.jcf.2018.05.001

Correcting for tissue nitrogen excretion in multiple breath washout measurements

PLoS ONE

Kane, M. and Rayment, J.H. and Jensen, R. and McDonald, R. and Stanojevic, S. and Ratjen, F.

DOI: 10.1371/journal.pone.0185553

Concomitant diffuse alveolar hemorrhage and pulmonary embolism in a child with isolated pulmonary capillaritis

Annals of the American Thoracic Society

Rayment, J.H. and Cutz, E. and Levy, D.M. and Dell, S.D.

DOI: 10.1513/AnnalsATS.201610-783LE

Chronic Hypoxemia in a 2-Year-Old Boy

Annals of the American Thoracic Society

Rayment, J.H. and Ahmareen, O. and John, P.R. and Ratjen, F.

DOI: 10.1513/AnnalsATS.201701-069CC

Another brick in the wall: Lung clearance index and lower airways pathology in preschool cystic fibrosis

Annals of the American Thoracic Society

Rayment, J.H. and Ratjen, F.

DOI: 10.1513/AnnalsATS.201706-432ED

Correlation of lung clearance index with hyperpolarized 129xe magnetic resonance imaging in pediatric subjects with cystic fibrosis

American Journal of Respiratory and Critical Care Medicine

Kanhere, N. and Couch, M.J. and Kowalik, K. and Zanette, B. and Rayment, J.H. and Manson, D. and Subbarao, P. and Ratjen, F. and Santyr, G.

DOI: 10.1164/rccm.201611-2228LE

Pulmonary Aspergillosis in a Previously Healthy 13-Year-Old Boy

Canadian Respiratory Journal

Rayment, J.H. and Narang, I.

DOI: 10.1155/2016/4575942

Culture-positive pediatric tuberculosis in Toronto, Ontario

Pediatric Infectious Disease Journal

Rayment, J.H. and Guthrie, J.L. and Lam, K. and Whelan, M. and Lee, B. and Jamieson, F.B. and Kitai, I.

DOI: 10.1097/INF.0000000000000915

Constrictive bronchiolitis: A distinct phenotype of cystic fibrosis lung disease?

Annals of the American Thoracic Society

Rayment, J.H. and Ratjen, F.

DOI: 10.1513/AnnalsATS.201609-701ED

ATS core curriculum 2016: Part III. Pediatric pulmonary medicine

Annals of the American Thoracic Society

Boyer, D. and Thomson, C.C. and Cohen, R. and Rao, D. and Dell, S. and Rayment, J. and Wang, R. and Dy, F.J. and Wambach, J. and Tam-Williams, J. and Simon, D. and Price, E. and Oermann, C.M. and Singh, A. and Rettig, J.S. and Duncan, E.D. and Baker, C.D. and Liptzin, D.R. and Moore, P.E.

DOI: 10.1513/AnnalsATS.201602-097CME

An unusual cause of empyema in a teenage boy

CMAJ

Rayment, J.H. and Weinstein, M.

DOI: 10.1503/cmaj.122089

Impact of the sentinel node frozen section result on the probability of additional nodal metastases as predicted by the MSKCC nomogram in breast cancer

Japanese Journal of Clinical Oncology

Jamal, M.H. and Rayment, J.H. and Meguerditchian, A. and Doi, S.A.R. and Meterissian, S.

DOI: 10.1093/jjco/hyq225

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: Implications for human breast cancer

Oncogene

Pontier, S.M. and Huck, L. and White, D.E. and Rayment, J. and Sanguin-Gendreau, V. and Hennessy, B. and Zuo, D. and St-Arnaud, R. and Mills, G.B. and Dedhar, S. and Marshall, C.J. and Muller, W.J.

DOI: 10.1038/onc.2010.86

Addressing the role of cell adhesion in tumor cell dormancy

Cell Cycle

White, D.E. and Rayment, J.H. and Muller, W.J.

DOI: 10.4161/cc.5.16.2993

Amino acids as placeholders: Base-composition pressures on protein length in malaria parasites and prokaryotes

Applied Bioinformatics

Rayment, J.H. and Forsdyke, D.R.

DOI: 10.2165/00822942-200504020-00005

Current Projects

Due to the remarkable advances in the care of children with cystic fibrosis (CF) over the past 3 decades, the traditional pulmonary function tests in most paediatric CF patients are normal. Despite this, we know that there is structural damage, inflammation and infection in the lungs of these children from an early age. In addition, new medical therapies for CF are leading to a monumental shift in how this disease is treated -- but again, if traditional pulmonary function testing is "normal" at the onset of therapy, it will not be sufficient to monitor response to treatment. For these reasons, new markers of lung health and disease are needed in this population. My research interests focus on the development of two types or pulmonary biomarkers: pulmonary function and imaging.

Multiple breath washout (MBW) testing is an old technique that has re-emerged in the literature over the past decade because it is extremely sensitive to the small airways disease that we see in early CF lung disease. There is, however, much that we don't know about this testing modality: how can/should it be used in a clinical setting? What constitutes a significant change between visits? Should a significant change in MBW outcomes prompt a change in clinical management? Through industry-initiated clinical trials and investigator-initiated studies, we hope to address these questions about this exciting new test.

Magnetic responance imaging is traditionally ineffective for imaging lung tissues, to its low proton density and high number of air/tissue interfaces. Novel techniques such as ultrashort echo time (UTE) MRI are improving the spatial resolution of pulmonary MRI, and are now being tested in children with CF. In addition, gas contrast imaging of the lungs using inhaled hyperpolarized noble gases (helium or xenon) allows for functional imaging. In collaboration with partners at UBC and St Paul's Hospital, I hope to develop a pediatric lung imaging research group at BCCH to use these emerging technologies in the investigation and care of children with lung disease.

Grants

CF Canada Clinical Fellowship 2016-17

Honours & Awards

2017 North American Cystic Fibrosis Conference Junior Clinical Investigator of the Year

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