Astrid De Souza

MSc, BSc

Affiliate Investigator and Clinical Exercise Physiologist, BC Children's Hospital

My research is focused on how exercise affects children with heart disease and other childhood diseases. Specifically, our group studies how exercise affects health outcomes, how it can be used as a tool to treat patients, and how behavioural change strategies are needed to help patients make changes to their exercise habits. I am also involved in work that looks at the use of digital health tools to deliver exercise programs, change behaviours and provide more comprehensive care for patients and their families. Finally, our group is involved at looking at the environmental impact and costs associated with travel to BC Children's Hospital.

Academic Affiliations

  • Clinical Instructor, Division of Cardiology, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Evidence to Innovation
  • Research Group(s): Clinical Practice, Outcomes and Innovation; Implementing Knowledge for Equity and System Change

Contact Information

Location

4480 Oak Street, Vancouver, British Columbia, Canada, V6H 3V4

Aerobic Fitness is Related to Sports Participation in Children with Congenital Heart Disease

Pediatric Cardiology

De Souza, A.-M. and Armstrong, K.R. and Hoskins, K. and Tran, N. and Naylor, K.C. and Romans, H.V. and Potts, J.E. and Hosking, M.C. and Clarke, D.C.

DOI: 10.1007/s00246-025-04014-0

Text messaging to improve connection between adolescents and their health care providers

Digital Health

Galvin, C.R. and De Souza, A.M. and Potts, J.E. and Sneddon, P.L. and Sanatani, S. and Armstrong, K.R.

DOI: 10.1177/20552076241309228

Establishment of emerging practices and research priorities for telerehabilitation in solid organ transplantation: meeting report and narrative literature review

Frontiers in Rehabilitation Sciences

Rozenberg, D. and Logan, S. and Sohrabipour, S. and Bourgeois, N. and Cote, A. and Deliva, R. and De Souza, A. and de Vries, R. and Donald, M. and Ferreira, M. and Hart, D. and Ibrahim Masthan, M. and Jaundis-Ferreira, T. and Juillard, S. and Khoury, M. and Lallani, A. and Mager, D. and Mucsi, I. and Orchanian-Cheff, A. and Reed, J.L. and Tandon, P. and Tennankore, K. and Yong, E. and Wickerson, L. and Mathur, S.

DOI: 10.3389/fresc.2025.1535138

An 8-Week Virtual Exercise Training Program for Pediatric Solid Organ Transplant Recipients

Pediatric Exercise Science

Grishin, N.K. and De Souza, A.M. and Fairbairn, J. and Sheel, A.W. and Puterman, E. and Blydt-Hansen, T. and Potts, J.E. and Armstrong, K.R.

DOI: 10.1123/pes.2023-0066

A text messaging intervention and quality of life in adolescents with solid organ transplants

Pediatric Transplantation

Rathgeber, S.L. and Hutchison, S.M. and De Souza, A.-M. and Lester, R. and Blydt-Hansen, T. and Human, D.G. and Guttman, O. and Oberlander, T. and Armstrong, K.R.

DOI: 10.1111/petr.14219

Adolescents with solid organ transplant: Using the BRIEF2 parent-report and self-report to measure parent-child agreement and everyday executive function

Applied Neuropsychology: Child

Hutchison, S.M. and Rathgeber, S.L. and De Souza, A.M. and Blydt-Hansen, T. and M{\^a}sse, L.C. and Armstrong, K.R. and Oberlander, T.F.

DOI: 10.1080/21622965.2020.1800468

Aortic Dimensions, Biophysical Properties, and Plasma Biomarkers in Children and Adults with Marfan or Loeys-Dietz Syndrome

CJC Open

Cui, J.Z. and Harris, K.C. and Raedschelders, K. and Hollander, Z. and Potts, J.E. and De Souza, A. and Kiess, M. and McManus, B.M. and Bernatchez, P. and Raffin, L.A. and Paine, H. and van Breemen, C. and Sandor, G.G.S. and Esfandiarei, M.

DOI: 10.1016/j.cjco.2020.12.018

Self-reported physical activity and lack of association with health-related quality of life in a pediatric solid-organ transplant population

Pediatric Transplantation

Lui, S. and Hind, T. and Moon, E. and de Souza, A. and Broad, K. and Fairbairn, J. and Schreiber, R. and Armstrong, K. and Blydt-Hansen, T.D.

DOI: 10.1111/petr.14093

Burst Exercise Testing Can Unmask Arrhythmias in Patients With Incompletely Penetrant Catecholaminergic Polymorphic Ventricular Tachycardia

JACC: Clinical Electrophysiology

Roston, T.M. and Kallas, D. and Davies, B. and Franciosi, S. and De Souza, A.M. and Laksman, Z.W. and Sanatani, S. and Krahn, A.D.

DOI: 10.1016/j.jacep.2021.02.013

Potential overdiagnosis of long QT syndrome using exercise stress and QT stand testing in children and adolescents with a low probability of disease

Journal of Cardiovascular Electrophysiology

Roston, T.M. and De Souza, A.M. and Romans, H.V. and Franciosi, S. and Armstrong, K.R. and Sanatani, S.

DOI: 10.1111/jce.14865

Somatic Symptom Disorder and the Physician's Role

JAMA Pediatrics

Galvin, C.R. and De Souza, A.M. and Armstrong, K.R.

DOI: 10.1001/jamapediatrics.2020.0165

Physical activity and its correlates in a pediatric solid-organ transplant population

Pediatric Transplantation

Lui, S. and de Souza, A. and Sharma, A. and Fairbairn, J. and Schreiber, R. and Armstrong, K. and Blydt-Hansen, T.

DOI: 10.1111/petr.13745

Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing

PLoS ONE

Bouquet, J. and Li, T. and Gardy, J.L. and Kang, X. and Stevens, S. and Stevens, J. and VanNess, M. and Snell, C. and Potts, J. and Miller, R.R. and Morshed, M. and McCabe, M. and Parker, S. and Uyaguari, M. and Tang, P. and Steiner, T. and Chan, W.-S. and De Souza, A.-M. and Mattman, A. and Patrick, D.M. and Chiu, C.Y.

DOI: 10.1371/journal.pone.0212193

Physiological Responses to Exercise in Pediatric Heart Transplant Recipients

Medicine and Science in Sports and Exercise

Bovard, J.M. and De Souza, A.M. and Harris, K.C. and Human, D.G. and Hosking, M.C.K. and Potts, J.E. and Armstrong, K. and Sandor, G.G.S. and Cote, A.T.

DOI: 10.1249/MSS.0000000000001889

Echocardiographic Assessment of Ventricular Function During Exercise in Adolescent Female Patients With Anorexia Nervosa

Journal of the American Society of Echocardiography

Escudero, C.A. and Potts, J.E. and Lam, P.-Y. and De Souza, A.M. and Duff, K. and Mugford, G.J. and Sandor, G.G.S.

DOI: 10.1016/j.echo.2018.10.014

Assessment of cardiovascular risk and preparticipation screening protocols in masters athletes: The Masters Athlete Screening Study (MASS): A cross-sectional study

BMJ Open Sport and Exercise Medicine

Morrison, B.N. and McKinney, J. and Isserow, S. and Lithwick, D. and Taunton, J. and Nazzari, H. and De Souza, A.M. and Heilbron, B. and Cater, C. and Macdonald, M. and Hives, B.A. and Warburton, D.E.R.

DOI: 10.1136/bmjsem-2018-000370

Doppler Echocardiography Assessment of Aortic Stiffness in Female Adolescents with Anorexia Nervosa

Journal of the American Society of Echocardiography

Escudero, C.A. and Potts, J.E. and Lam, P.-Y. and De Souza, A.M. and Mugford, G.J. and Sandor, G.G.S.

DOI: 10.1016/j.echo.2018.01.003

Stress Echocardiographic Evaluation for D-Transposition of the Great Arteries after Atrial Redirection: Unmasking Early Signs of Myocardial Dysfunction and Baffle Stenosis

Journal of the American Society of Echocardiography

Dvir-Orgad, M. and Anand, M. and De Souza, A.M. and Zadorsky, M.T. and Kiess, M.C. and Potts, J.E. and Sandor, G.G.S.

DOI: 10.1016/j.echo.2016.09.005

Response Letter to Optimising physiology for adolescents with dysautonomia

Acta Paediatrica, International Journal of Paediatrics

Armstrong, K.R. and De Souza, A.M. and Sneddon, P.L. and Potts, J.E. and Claydon, V.E. and Sanatani, S.

DOI: 10.1111/apa.14058

A novel treadmill protocol for exercise testing in children: The British Columbia Children's Hospital protocol

BMJ Open Sport and Exercise Medicine

Duff, D.K. and De Souza, A.M. and Human, D.G. and Potts, J.E. and Harris, K.C.

DOI: 10.1136/bmjsem-2016-000197

Physical activity and sedentary behavior in children with congenital heart disease

Journal of the American Heart Association

Voss, C. and Duncombe, S.L. and Dean, P.H. and de Souza, A.M. and Harris, K.C.

DOI: 10.1161/JAHA.116.004665

Aspirin dose and prevention of coronary abnormalities in Kawasaki disease

Pediatrics

Dallaire, F. and Fortier-Morissette, Z. and Blais, S. and Dhanrajani, A. and Basodan, D. and Renaud, C. and Mathew, M. and De Souza, A.M. and Dionne, A. and Blanchard, J. and Saulnier, H. and Kaspy, K. and Rached-D{'}Astous, S. and Dahdah, N. and McCrindle, B.W. and Human, D.G. and Scuccimarri, R.

DOI: 10.1542/peds.2017-0098

Exercise and the multidisciplinary holistic approach to adolescent dysautonomia

Acta Paediatrica, International Journal of Paediatrics

Armstrong, K.R. and De Souza, A.M. and Sneddon, P.L. and Potts, J.E. and Claydon, V.E. and Sanatani, S.

DOI: 10.1111/apa.13750

A Doppler Echocardiographic Study of the Myocardial Inotropic Response to Peak Semisupine Exercise in Healthy Children: Development of a Simplified Index ofMyocardialReserve

Journal of the American Society of Echocardiography

Cote, A.T. and Duff, D.K. and Escudero, C.A. and De Souza, A.M. and Williams, L.D. and Gill, R. and Zadorsky, M.T. and Harris, K.C. and Potts, J.E. and Sandor, G.G.S.

DOI: 10.1016/j.echo.2017.04.008

An Echocardiographic Study of Left Ventricular Size and Cardiac Function in Adolescent Females with Anorexia Nervosa

European Eating Disorders Review

Escudero, C.A. and Potts, J.E. and Lam, P.-Y. and De Souza, A.M. and Mugford, G.J. and Sandor, G.G.S.

DOI: 10.1002/erv.2409

Noninvasive Assessment of Vascular Function in Postoperative Cardiovascular Disease (Coarctation of the Aorta, Tetralogy of Fallot, and Transposition of the Great Arteries)

American Journal of Cardiology

Mivelaz, Y. and Leung, M.T. and Zadorsky, M.T. and De Souza, A.M. and Potts, J.E. and Sandor, G.G.S.

DOI: 10.1016/j.amjcard.2016.05.055

Feasibility of optical coherence tomography in children with Kawasaki disease and pediatric heart transplant recipients

Circulation: Cardiovascular Imaging

Harris, K.C. and Manouzi, A. and Fung, A.Y. and De Souza, A. and Bezerra, H.G. and Potts, J.E. and Hosking, M.C.K.

DOI: 10.1161/CIRCIMAGING.113.001764

Physical activity recommendations for patients with electrophysiologic and structural congenital heart disease: A survey of canadian health care providers

Pediatric Cardiology

Roston, T.M. and De Souza, A.M. and Sandor, G.G.S. and Sanatani, S. and Potts, J.E.

DOI: 10.1007/s00246-013-0654-z

Echo-doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease

Pediatric Cardiology

Alghamdi, M. and De Souza, A.M. and White, C.T. and Potts, M.T. and Warady, B.A. and Furth, S.L. and Kimball, T.R. and Potts, J.E. and Sandor, G.G.S.

DOI: 10.1007/s00246-013-0632-5

Echo-doppler assessment of arterial stiffness in pediatric patients with kawasaki disease

Journal of the American Society of Echocardiography

Alhuzaimi, A. and Al Mashham, Y. and Potts, J.E. and De Souza, A.M. and Sandor, G.G.S.

DOI: 10.1016/j.echo.2013.05.015

Biophysical properties of the aorta and left ventricle and exercise capacity in obese children

American Journal of Cardiology

Harris, K.C. and Al Saloos, H.A. and De Souza, A.M. and Sanatani, S. and Hinchliffe, M. and Potts, J.E. and Sandor, G.G.S.

DOI: 10.1016/j.amjcard.2012.05.019

Serial measurements of exercise performance in pediatric heart transplant patients using stress echocardiography

Pediatric Transplantation

Yeung, J.P. and Human, D.G. and Sandor, G.G.S. and De Souza, A.M. and Potts, J.E.

DOI: 10.1111/j.1399-3046.2010.01467.x

Early Changes in the Biophysical Properties of the Aorta in Pre-Adolescent Children Born Small for Gestational Age

Journal of Pediatrics

Bradley, T.J. and Potts, J.E. and Lee, S.K. and Potts, M.T. and De Souza, A.M. and Sandor, G.G.S.

DOI: 10.1016/j.jpeds.2009.10.002

A stress echocardiography study of cardiac function during progressive exercise in pediatric oncology patients treated with anthracyclines

Pediatric Blood and Cancer

De Souza, A.M. and Potts, J.E. and Potts, M.T. and De Souza, E.S. and Rowland, T.W. and Pritchard, S.L. and Sandor, G.G.S.

DOI: 10.1002/pbc.21122

Virtual Reality and Gameplay as a Model for Exercise Rehabilitation in Pediatric Solid Organ Transplant Patients

Building on previous work that delivered a virtual exercise program to children with a solid organ transplant, this study looks at whether virtual reality gameplay yields a sufficient training stimulus to mimic traditional exercise.

Complementing Care in Cardiology: The use of mobile health technology to support patients and families in the Children’s Heart Centre

This study builds on initial work in our solid organ transplant and adolescent dysautonomia populations where a clinical digital messaging platform was employed to try to improve communication and in turn quality of life in these patients. Now, we have expanded the use of the clinical digital messaging platform to include a widespread group of patients seen in the Children’s Heart Centre.

Is exercise capacity related to sports participation in children with congenital heart disease?

This study aims to evaluate how sports participation affects exercise capacity in children with congenital heart disease. The goal of this work is to elucidate the factors that may influence exercise capacity in these children.

Grants

Transplant Research Foundation of BC Venture Grant and CDTRP Venture Grant (2022) - Virtual Reality and Gameplay as a Model for Exercise Rehabilitation in Pediatric Solid Organ Transplant Patients. A Patient and Family Led Initiative

Digital Health Research (DHR) Accelerator Grant (2021) - Using clinical digital messaging to improve pediatric congenital heart disease patient care, health outcomes, patient satisfaction, facilitators, and barriers to implementation

Transplant Research Foundation of BC Venture Grant (2020) - VEXT: An 8-week virtual exercise and texting program for pediatric solid organ transplant patients

Transplant Research Foundation of BC Venture Grant (2018) - Let’s Text: Engaging Adolescent Solid Organ Transplant Patients in Managing their Health

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