Thiviya Selvanathan

(she/her)
MD, PhD

Investigator, BC Children's Hospital Research Institute
Pediatric Neurologist, BC Children's Hospital
Assistant Professor, Department of Pediatrics, University of British Columbia

My research uses new Magnetic Resonance Imaging (MRI) and brain monitoring techniques to identify how early-life brain injury, clinical illness, and social determinants of health impact neurodevelopment in newborns at high risk for developmental disabilities. I am also interested in understanding long-term developmental trajectories in children with early-life brain injury. Understanding what factors impact brain development may point to new strategies for promoting long-term brain health in high-risk infants.

Academic Affiliations

  • Assistant Professor, Division of Neurology, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Brain, Behaviour & Development
  • Research Group(s): Neurodevelopmental and Neurological Disorders; Visualizing the Brain

Contact Information

Location

950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4

Prevalence of Ischemic Brain Injury in Neonates With Congenital Heart Disease

Neurology

Caroline Kim and Devin Chetan and Vanna Kazazian and Jawad Alzamil and Vann Chau and Mike Seed and Steven P. Miller and Thiviya Selvanathan

DOI: 10.1212/WNL.0000000000214569

02 / 2026

Beyond brain injury: rethinking neurodevelopment in neonatal encephalopathy

Pediatric Research

Thiviya Selvanathan

DOI: 10.1038/s41390-025-04659-w

12 / 2025

Brain imaging as a predictor of neurodevelopmental outcomes in neonatal encephalopathy

Pediatric Research

Kia Anarna and Dawn Gano and Thiviya Selvanathan

DOI: 10.1038/s41390-025-04696-5

12 / 2025

Neonatal Sucrose and Internalizing Behaviors at 18 Months in Children Born Very Preterm

JAMA Network Open

McLean, M.A. and Ranger, M. and Bone, J.N. and Selvanathan, T. and Au-Young, S.H. and Chau, C.M.Y. and Chau, V. and Ly, L. and Kelly, E. and Synnes, A. and Miller, S.P. and Grunau, R.E.

DOI: 10.1001/jamanetworkopen.2025.4477

Punctate White Matter Abnormality in Moderate-to-Late Preterm Infants

Annals of Neurology

Kennedy, E. and Guo, T. and Williams, S. and Selvanathan, T. and Alsweiler, J.M. and Bloomfield, F.H. and Battin, M. and Dubowitz, D. and Miller, S.P. and Morgan, C. and Perry, D. and Stott, N.S. and Harding, J.E.

DOI: 10.1002/ana.27261

Association of Early-Life or Term-Equivalent White Matter Injury With Neurodevelopmental Outcomes in Very Preterm Infants

Neurology

Selvanathan, T. and Oloomi, S. and Guo, T. and Ufkes, S. and Chau, V. and Branson, H. and Synnes, A. and Ly, L.G. and Kelly, E.N. and De Vries, L.S. and Grunau, R.E. and Miller, S.P.

DOI: 10.1212/WNL.0000000000214016

Promoting Healthy Early Brain Development

Pediatric Clinics of North America

Selvanathan, T. and Miller, S.P.

DOI: 10.1016/j.pcl.2025.07.001

Punctate white matter lesions predict risk for cerebral palsy: further evidence for routine brain MRI in preterm infants

Pediatric Research

Selvanathan, T. and Gano, D.

DOI: 10.1038/s41390-025-04333-1

Advances in Neonatal Hypoxic-Ischemic Encephalopathy

Pediatric Clinics of North America

Konrad, J. and Chau, V. and Selvanathan, T.

DOI: 10.1016/j.pcl.2025.05.006

Neonatal Critical Illness, 8-Year White Matter Microstructure, and Motor Function in Children Born Very Preterm

Journal of Pediatrics

Oloomi, S. and Ufkes, S. and Selvanathan, T. and Chau, C. and Roland, E. and Guo, T. and Chau, V. and Grunau, R.E. and Miller, S.P.

DOI: 10.1016/j.jpeds.2025.114667

Hemodynamic Risk Factors for Cerebellar Hemorrhage Presence and Volume in Infants Born Very Preterm

Journal of Pediatrics

Ybarra, M. and Selvanathan, T. and Guo, T. and Chau, V. and Branson, H.M. and Ly, L.G. and Synnes, A.R. and Kelly, E. and Grunau, R.E. and Miller, S.P. and Tam, E.W.Y.

DOI: 10.1016/j.jpeds.2025.114503

Head growth trajectories as a window into neurodevelopment in preterm infants

Jornal de Pediatria

Selvanathan, T.

DOI: 10.1016/j.jped.2024.07.001

Pain Exposure and Brain Connectivity in Preterm Infants

JAMA Network Open

Selvanathan, T. and Ufkes, S. and Guo, T. and Chau, V. and Branson, H.M. and Ibrahim, G.M. and Ly, L.G. and Kelly, E.N. and Grunau, R.E. and Miller, S.P.

DOI: 10.1001/jamanetworkopen.2024.2551

Socioeconomic status moderates associations between hippocampal development and cognition in preterms

Annals of Clinical and Translational Neurology

Konrad, J. and Guo, T. and Ufkes, S. and Selvanathan, T. and Sheng, M. and Al-Ajmi, E. and Branson, H.M. and Chau, V. and Ly, L.G. and Kelly, E.N. and Grunau, R.E. and Miller, S.P.

DOI: 10.1002/acn3.52168

Perinatal stroke and neonatal hypoxic-ischemic encephalopathy co-occur: role of intrapartum events

Pediatric Research

Selvanathan, T. and Miller, S.P.

DOI: 10.1038/s41390-024-03710-6

Neuromonitoring practices for neonates with congenital heart disease: a scoping review

Pediatric Research

Pardo, A.C. and Carrasco, M. and Wintermark, P. and Nunes, D. and Chock, V.Y. and Sen, S. and Wusthoff, C.J. and Bonifacio, S. and Aly, H. and Chau, V. and Glass, H. and Lemmon, M. and deVeber, G. and Boardman, J.P. and Gano, D. and Peeples, E. and Leijser, L.M. and Nakwa, F. and Selvanathan, T.

DOI: 10.1038/s41390-024-03484-x

Challenging Current Perspectives of Neonatal Hypoxic-Ischemic Encephalopathy: Is Encephalopathy Necessary?

Neurology

Selvanathan, T. and Miller, S.P.

DOI: 10.1212/WNL.0000000000209212

Size and Location of Preterm Brain Injury and Associations with Neurodevelopmental Outcomes

Neurology

Selvanathan, T. and Guo, T. and Ufkes, S. and Chau, V. and Branson, H. and Synnes, A. and Ly, L.G. and Kelly, E.N. and Grunau, R.E. and Miller, S.P.

DOI: 10.1212/WNL.0000000000209264

Families as partners in neonatal neuro-critical care programs

Pediatric Research

Bansal, S. and Molloy, E.J. and Rogers, E. and Bidegain, M. and Pilon, B. and Hurley, T. and Lemmon, M.E. and Selvanathan, T. and Nakwa, F. and Leijser, L. and Wusthoff, C. and Peeples, E. and Pardo, A. and Glass, H. and Gano, D. and deVeber, G. and Chau, V. and McCaul, M.C. and Boardman, J. and Aly, H. and Wintermark, P. and Bonifacio, S.

DOI: 10.1038/s41390-024-03257-6

Fetal Hemodynamics, Early Survival, and Neurodevelopment in Patients With Cyanotic Congenital Heart Disease

Journal of the American College of Cardiology

Lee, F.-T. and Sun, L. and van Amerom, J.F.P. and Portnoy, S. and Marini, D. and Saini, A. and Milligan, N. and Lim, J.M. and Saini, B. and Selvanathan, T. and Kazazian, V. and Sananes, R. and Jaeggi, E. and Kingdom, J.C. and Macgowan, C.K. and Ly, L. and Chau, V. and Miller, S.P. and Seed, M.

DOI: 10.1016/j.jacc.2024.02.005

Factors affecting brain maturation trajectories in early childhood

The Lancet Neurology

Selvanathan, T. and Miller, S.P.

DOI: 10.1016/S1474-4422(24)00089-9

Effects of pain, sedation and analgesia on neonatal brain injury and brain development

Seminars in Perinatology

Selvanathan, T. and Miller, S.P.

DOI: 10.1016/j.semperi.2024.151928

Brain health in preterm infants: importance of early-life pain and analgesia exposure

Pediatric Research

Selvanathan, T. and Miller, S.P.

DOI: 10.1038/s41390-024-03245-w

Antenatal diagnosis, neonatal brain volumes, and neurodevelopment in transposition of the great arteries

Developmental Medicine and Child Neurology

Selvanathan, T. and Mabbott, C. and Au-Young, S.H. and Seed, M. and Miller, S.P. and Chau, V.

DOI: 10.1111/dmcn.15840

Change in Volumes and Location of Preterm White Matter Injury over a Period of 15 Years

Journal of Pediatrics

Selvanathan, T. and Guo, T. and Ufkes, S. and Chau, V. and Branson, H.M. and Synnes, A.R. and Ly, L.G. and Kelly, E. and Grunau, R.E. and Miller, S.P.

DOI: 10.1016/j.jpeds.2024.114090

Perinatal Risk and Later Intellectual and Developmental Disabilities

Contemporary Clinical Neuroscience

Gigliotti-Manessis, A. and Rutter, T.M. and Cook, K. and Merrill, L. and Korom, M. and Selvanathan, T. and Camacho, M.C. and Bick, J.

DOI: 10.1007/978-3-031-66932-3_9

Abstract 14028: Stroke Location, White Matter Disconnections, and Neurodevelopmental Outcomes in Infants With Congenital Heart Disease

Circulation

Thiviya Selvanathan and Ting Guo and Shabnam Peyvandi and Anne Synnes and Vann Chau and Linh Ly and ANTHONY J BARKOVICH and Mike Seed and Patrick S McQuillen and Steven P Miller

DOI: 10.1161/circ.148.suppl_1.14028

11 / 2023

Neurodevelopment in Children With Congenital Heart Disease: An Opportunity for the Cardiovascular Trainee

Canadian Journal of Cardiology

Chetan, D. and Selvanathan, T. and Alzamil, J. and Chau, V. and Seed, M.

DOI: 10.1016/j.cjca.2023.03.009

Declining Incidence of Postoperative Neonatal Brain Injury in Congenital Heart Disease

Journal of the American College of Cardiology

Peyvandi, S. and Xu, D. and Barkovich, A.J. and Gano, D. and Chau, V. and Reddy, V.M. and Selvanathan, T. and Guo, T. and Gaynor, J.W. and Seed, M. and Miller, S.P. and McQuillen, P.

DOI: 10.1016/j.jacc.2022.10.029

Child Neurology: Cortical Malformations in Preterm Infants: Case From a Prospective Cohort

Neurology

Selvanathan, T. and Guillot, M. and Branson, H.M. and Chau, V. and Kelly, E.N. and Miller, S.P.

DOI: 10.1212/WNL.0000000000207265

Congenital heart disease: An important cause of brain injury and dysmaturation

Neonatology Questions and Controversies Neurology

Selvanathan, T. and Seed, M. and Chau, V.

DOI: 10.1016/B978-0-323-88077-0.00025-0

Major Surgery, Brain Injury, and Neurodevelopmental Outcomes in Very Preterm Infants

Neurology

Selvanathan, T. and Au-Young, S.H. and Guo, T. and Chau, V. and Branson, H.M. and Synnes, A. and Ly, L. and Kelly, E.N. and Grunau, R.E. and Miller, S.P.

DOI: 10.1212/WNL.0000000000207848

Early-life exposure to analgesia and 18-month neurodevelopmental outcomes in very preterm infants

Pediatric Research

Selvanathan, T. and Zaki, P. and McLean, M.A. and Au-Young, S.H. and Chau, C.M.Y. and Chau, V. and Synnes, A.R. and Ly, L.G. and Kelly, E. and Grunau, R.E. and Miller, S.P.

DOI: 10.1038/s41390-023-02536-y

Head circumference, total cerebral volume and neurodevelopment in preterm neonates

Archives of Disease in Childhood - Fetal and Neonatal Edition

Thiviya Selvanathan and Ting Guo and Eddie Kwan and Vann Chau and Rollin Brant and Anne R Synnes and Ruth E Grunau and Steven P Miller

DOI: 10.1136/archdischild-2020-321397

03 / 2022

Neurodevelopment and Cognition Across the Lifespan in Patients With Single-Ventricle Physiology: Abnormal Brain Maturation and Accumulation of Brain Injuries

Canadian Journal of Cardiology

Selvanathan, T. and Smith, J.M.C. and Miller, S.P. and Field, T.S.

DOI: 10.1016/j.cjca.2022.02.009

Proceedings of the 13th International Newborn Brain Conference: Neuroprotection strategies in the neonate

Journal of neonatal-perinatal medicine

Abou Mehrem, A. and Al Awad, E. and Anninck, K. and Au-Young, S. and Aydinol, N. and Bartmann, P. and Benders, M. and Benlamri, A. and Bolderheij, L. and Celik, Y. and Chan, N. and Chau, C. and Chau, V. and Chen, X. and Chetcuti Ganado, C. and Coetser, A. and Cools, F. and Da Rocha, G. and Deigner, H.-P. and Dereymaeker, A. and Deshmukh, L. and Domonoske, R. and Dossani, S. and Dsouza, J.M. and El Gamal, M. and Eshemokhai, P. and Esser, M. and Fiedrich, E. and Franz, A. and Ghosh, A. and Groenendaal, F. and Grunau, R.E. and Venkata, S.K.R.G. and Hamitoglu, S. and Hellstr{\"o}m-Westas, L. and Irvine, L. and Jansen, K. and Javadyan, A. and Jenkin, G. and Kamanga, N. and Kaur, N. and Keles, E. and Keller, M. and Kelly, E. and Kesting, S.J. and Kgwadi, D. and Kim, B. and Kohl, M. and Kowal, D. and Kricitober, J.D. and Leijser, L. and LePine, M. and Lim, Y.-P. and Lodha, A. and Londhe, A. and Ly, L. and Maes, E. and Malhotra, A. and Marlow, N. and Mathew, J.L. and McDonald, C. and McLean, M. and Metcalfe, C. and Meyer, R. and Miller, S.P. and Miller, S. and Mogajane, T. and Mohammad, K. and Momin, S. and Montpetit, J. and Mukiza, N. and Murthy, P. and Scott, J.N. and Nakibuuka, V. and Nakwa, F. and Naulaers, G. and Noort, J. and Ntuli, N. and Ondongo-Ezhet, C. and Paul, R. and Pepper, M. and Plum, A. and Rombough, B. and Saugstad, O. and Scotland, J. and Scott, J. and Seake, K. and Sebunya, R. and Selvanathan, T. and Sepeng, L. and Simsek, H. and Steins-Rang, C. and Stonestreet, B. and Tang, S. and Taskin, E. and Thewissen, L. and Thomas, S. and Thomas, R. and van Kwawegen, A. and van Rensburg, J. and Velaphi, S. and Wu, Y. and Yaman, A. and Yapicioglu-Yildizdas, H. and Yawno, T. and Zaki, P. and Zein, H. and Zhou, L.

DOI: 10.3233/NPM-229003

Pearls & Oy-sters: Genetic Epilepsy: An Important Cause of Neonatal Seizures in Infants with Complex Congenital Heart Disease

Neurology

Kazazian, V. and Selvanathan, T. and Chau, V. and Tam, E.W.Y. and Miller, S.P.

DOI: 10.1212/WNL.0000000000201229

Abstract 10072: Stroke Topology and Neurodevelopment in Infants with Congenital Heart Disease: Does it Differ by Cardiac Physiology?

Circulation

Thiviya Selvanathan and Ting Guo and Min Sheng and Mike Seed and Anne Synnes and Shabnam Peyvandi and Liza Pulcine and Vann Chau and Linh G Ly and James Barkovich and Patrick S McQuillen and Steven P Miller

DOI: 10.1161/circ.144.suppl_1.10072

11 / 2021

Early EEG in neonates with mild hypoxic"ischemic encephalopathy: more than meets the eye

Pediatric Research

Selvanathan, T. and Miller, S.P.

DOI: 10.1038/s41390-021-01514-6

Long-term postnatal outcome of fetuses with prenatally suspected septo-optic dysplasia

Ultrasound in Obstetrics and Gynecology

Shinar, S. and Blaser, S. and Chitayat, D. and Selvanathan, T. and Chau, V. and Shannon, P. and Agrawal, S. and Ryan, G. and Pruthi, V. and Miller, S.P. and Krishnan, P. and Van Mieghem, T.

DOI: 10.1002/uog.22018

Imaging microglial activation in untreated first-episode psychosis: A PET study with [18F]FEPPA

American Journal of Psychiatry

Hafizi, S. and Tseng, H.-H. and Rao, N. and Selvanathan, T. and Kenk, M. and Bazinet, R.P. and Suridjan, I. and Wilson, A.A. and Meyer, J.H. and Remington, G. and Houle, S. and Rusjan, P.M. and Mizrahi, R.

DOI: 10.1176/appi.ajp.2016.16020171

Imaging neuroinflammation in gray and white matter in schizophrenia: An in-vivo PET study with [18 F]-FEPPA

Schizophrenia Bulletin

Kenk, M. and Selvanathan, T. and Rao, N. and Suridjan, I. and Rusjan, P. and Remington, G. and Meyer, J.H. and Wilson, A.A. and Houle, S. and Mizrahi, R.

DOI: 10.1093/schbul/sbu157

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA

Neuroimage

Suridjan, I. and Rusjan, P.M. and Voineskos, A.N. and Selvanathan, T. and Setiawan, E. and Strafella, A.P. and Wilson, A.A. and Meyer, J.H. and Houle, S. and Mizrahi, R.

DOI: 10.1016/j.neuroimage.2013.09.021

Intersection of Social Determinants, Brain Injury and Brain Dysmaturation, and Associations with Neurodevelopment in Children with Congenital Heart Disease

Infants with congenital heart disease are at increased risk for brain injury and abnormalities in brain maturation (brain dysmaturation) that contribute to an increased risk for neurodevelopmental problems. However, social disparities have also been linked to poorer childhood neurodevelopmental outcomes. Children with congenital heart disease in whom these factors intersect may be particularly vulnerable. This project aims to understand how social disparity modifies the relationships between brain injury, brain maturation and neurodevelopmental outcomes in children with congenital heart disease. There will be a specific focus on identifying the specific pathways through which social determinants impact neurodevelopment, which may point to potential interventions to more equitably promote brain health in this population.

Brain Connectome and Neurodevelopment in Neonatal Hypoxic-Ischemic Encephalopathy (HIE Connectome Study & MEG HIE Study)

Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal brain injury and long-term disability. While brain MRI helps assess injury patterns, it cannot reliably predict which infants will face developmental challenges. These studies aim to improve early identification of at-risk infants by examining how brain connectivity, early-life pain exposure, and biological sex influence neurodevelopmental outcomes. By using advanced imaging, including MRI at birth and 3 months, and magnetoencephalography (MEG) at 8 months, to evaluate how the brain’s functional networks, its connectome, develop after injury. MEG, a non-invasive technique that captures real-time brain activity, offers unique insight into how neural pathways mature beyond what MRI alone can show.

By combining MEG and MRI data with detailed neurodevelopmental assessments, the studies will explore how brain connectivity disruptions relate to cognitive, motor, and social outcomes. They will also investigate how pain and sedation in the neonatal intensive care unit, and biological sex differences, impact brain development and recovery. Findings will help refine prognostic tools, guide personalized early interventions, and inform best practices in clinical care, including more tailored pain management and sex-specific support strategies for infants with HIE.

Brain Health in Adolescents with Neonatal Hypoxic-Ischemic Encephalopathy (Adolescent HIE Study)

Less is known about the long-term impacts of neonatal hypoxic-ischemic encephalopathy (HIE) on brain health into adolescence. This study follows individuals with a history of neonatal HIE to assess cognitive, motor, and psychosocial outcomes, as well as changes in brain development over time. The goal is to better understand the long-term effects of early-life brain injury and identify factors that influence resilience or increased risk for neurodevelopmental challenges.

Neonatal HIE and Brain Maturation: 20-Year Retrospective Cohort (Retrospective HIE Study)

This study investigates the long-term effects of neonatal hypoxic-ischemic encephalopathy (HIE) on brain maturation and neurodevelopment by analyzing a 20-year retrospective cohort. While existing tools can predict the risk of cerebral palsy, less is known about the long-term trajectory of other neurodevelopmental outcomes in individuals with HIE. By examining historical neuroimaging and clinical data, the study aims to identify patterns of brain maturation, assess associations with non-cerebral palsy impairments, and uncover biomarkers that can improve early identification and intervention strategies for at-risk children.

The Heart-Brain Connection in Neonatal Hypoxic-Ischemic Encephalopathy: Hemodynamic Alterations and Brain Injury Severity (Heart-Brain Connection)

Neonatal hypoxic-ischemic encephalopathy (HIE) results from reduced oxygen and blood flow at birth and can lead to lasting brain injury and developmental challenges. This study investigates how early heart function—specifically right ventricular performance—relates to the severity of brain injury in newborns with HIE. Using echocardiography and brain MRI, researchers aim to understand the interplay between cardiovascular health and brain development. By identifying heart-related markers of brain injury risk, this research may improve early prognostic tools and guide more tailored clinical care.

Honours & Awards

CIHR Canada Graduate Scholarship – Master’s Award (2020-2021)

SickKids RI Clinician Scientist Training Program (2020-2023)

Ontario Ministry of Health – Clinician Investigator Program (2020-2021)

CIHR Canada Graduate Scholarship – Doctoral Award (2022-2023)

NBS Early Career Award – 1/2025-12/2025 (Social disparity, thalamic volumes, and cognition in adolescents with neonatal HIE)

CIHR Project Grant – 4/2025-3/2030 (Brain Connectome and Neurodevelopment in Neonatal Hypoxic-Ischemic Encephalopathy)

BB&D Catalyst Grant – 2/2025-2/2026 (The Heart-Brain Connection in Neonatal Hypoxic-Ischemic Encephalopathy: Hemodynamic Alterations and Brain Injury Severity)

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