Mady Salker

PhD, MRSB, Habilitation

Investigator, BC Children's Hospital

Our research specifically explores how proteins within the endometrium behave to improve our understanding of maternal and infant health.

Academic Affiliations

  • Assistant Professor, Division of Reproductive Endocrinology & Infertility, Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia
  • Research Theme: Healthy Starts
  • Research Group(s): Global Health and Innovations; Implementing Knowledge for Equity and System Change; Pathways to Healthy Birth

Contact Information

Location

4500 Oak Street, Vancouver, British Columbia, Canada, V6H 3N1

Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women

Frontiers in Immunology

Salker, M.S. and Abd Aziz, N.H. and Prodan, N.C. and Yang, Z. and Lankapalli, A.K. and Lazar, K. and Shafiee, M.N. and Kocak, E. and Ganesan, H. and Pal, S.S. and Khalid, O. and Kasim, N.M. and Kalok, A. and Fuad, N.A. and Bissinger, A.L. and Ganzenmueller, T. and Iftner, T. and Kagan, K.O. and Ossowski, S. and Casadei, N. and Brucker, S.Y. and Riess, O. and Singh, Y.

DOI: 10.3389/fimmu.2025.1560391

Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy

Clinical Science

Liu, A. and Ruetalo, N. and Raja Xavier, J.P. and Lankapalli, A.K. and Admard, J. and Camarena-Sainz, M. and Brucker, S.Y. and Singh, Y. and Schindler, M. and Salker, M.S.

DOI: 10.1042/CS20241215

Inhibition of placental trophoblast fusion by guanylate-binding protein 5

Science Advances

Krchlikova, V. and Braun, E. and Weiss, J. and Stafl, K. and Jech, L. and Badarinarayan, S.S. and Lotke, R. and Travnicek, M. and Baur, C. and Stark, P. and Haussmann, I. and Lu, Y. and Petersen, M. and Cui, W. and Wang, W. and F{\"a}ger, B.M. and Reisinger, H. and Tokunaga, K. and Cing{\"o}z, O. and Sparrer, K.M.J. and Salker, M.S. and Hejnar, J. and Kirchhoff, F. and Trejbalova, K. and Sauter, D.

DOI: 10.1126/sciadv.adt5388

Optimizing the use of in vitro transcribed SGK1-mRNA as a therapeutic tool to treat female infertility

BMC Research Notes

Sahu, I. and Engelmann, F. and Weidensee, B. and Ganesan, H. and Brucker, S.Y. and Singh, Y. and Salker, M.S.

DOI: 10.1186/s13104-025-07346-5

Embryo-derived trypsin-induced calcium entry is inhibited by endometrial infertility factor, LEFTY2

Frontiers in Cell and Developmental Biology

Yang, Z. and Yan, J. and Kull, S. and Alauddin, M. and Brucker, S.Y. and Henes, M. and Lang, F. and Salker, M.S.

DOI: 10.3389/fcell.2025.1499339

Placental growth factor mediates pathological uterine angiogenesis by activating the NFAT5-SGK1 signaling axis in the endometrium: implications for preeclampsia development

Biological Research

Raja Xavier, J.P. and Okumura, T. and Apweiler, M. and Chacko, N.A. and Singh, Y. and Brucker, S.Y. and Takeda, S. and Lang, F. and Salker, M.S.

DOI: 10.1186/s40659-024-00526-w

Rel Family Transcription Factor NFAT5 Upregulates COX2 via HIF-1a Activity in Ishikawa and HEC1a Cells

International Journal of Molecular Sciences

Okumura, T. and Raja Xavier, J.P. and Pasternak, J. and Yang, Z. and Hang, C. and Nosirov, B. and Singh, Y. and Admard, J. and Brucker, S.Y. and Kommoss, S. and Takeda, S. and Staebler, A. and Lang, F. and Salker, M.S.

DOI: 10.3390/ijms25073666

Excessive endometrial PlGF- Rac1 signalling underlies endometrial cell stiffness linked to pre-eclampsia

Communications Biology

Raja Xavier, J.P. and Rianna, C. and Hellwich, E. and Nikolou, I. and Lankapalli, A.K. and Brucker, S.Y. and Singh, Y. and Lang, F. and Sch{\"a}ffer, T.E. and Salker, M.S.

DOI: 10.1038/s42003-024-06220-7

Receptor usage of Syncytin-1: ASCT2, but not ASCT1, is a functional receptor and effector of cell fusion in the human placenta

Proceedings of the National Academy of Sciences of the United States of America

?tafl, K. and Tr{\'a}vn{\'i}?ek, M. and Janovsk{\'a}, A. and Ku?erov{\'a}, D. and Pecnov{\'a}, ?. and Yang, Z. and Stepanec, V. and Jech, L. and Salker, M.S. and Hejnar, J. and Trejbalov{\'a}, K.

DOI: 10.1073/pnas.2407519121

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

Molecular Neurodegeneration

Singh, Y. and Trautwein, C. and Romani, J. and Salker, M.S. and Neckel, P.H. and Fraccaroli, I. and Abeditashi, M. and Woerner, N. and Admard, J. and Dhariwal, A. and Dueholm, M.K.D. and Sch{\"a}fer, K.-H. and Lang, F. and Otzen, D.E. and Lashuel, H.A. and Riess, O. and Casadei, N.

DOI: 10.1186/s13024-023-00628-1

Dysregulated Exosomes Result in Suppression of the Immune Response of Pregnant COVID-19 Convalescent Women

Frontiers in Molecular Biosciences

Cao, H. and Abd Aziz, N.H. and Xavier, J.R. and Shafiee, M.N. and Kalok, A. and Jee, B. and Salker, M.S. and Singh, Y.

DOI: 10.3389/fmolb.2022.869192

SARS-CoV-2 Infection in Pregnancy: Placental Histomorphological Patterns, Disease Severity and Perinatal Outcomes

International Journal of Environmental Research and Public Health

Wong, Y.P. and Tan, G.C. and Omar, S.Z. and Mustangin, M. and Singh, Y. and Salker, M.S. and Abd Aziz, N.H. and Shafiee, M.N.

DOI: 10.3390/ijerph19159517

Immune dynamics at single cell protein level after delta/omicron infection in COVID-19 vaccinated convalescent individuals

Biorxiv

Bajaj, R. and Yang, Z. and Hammer, V. and P{\"o}schel, S. and Bieber, K. and Salker, M.S. and Casadei, N. and Ossowski, S. and Riess, O. and Singh, Y.

DOI: 10.1101/2022.09.05.506626

Comparative multi-OMICS single cell atlas of five COVID-19 (rAdVV and mRNA) vaccines describe unique and distinct mechanisms of action

Biorxiv

Singh, Y. and Selting, A.S. and Gabernet, G. and Ray, U. and Bajaj, R. and Ali, M. and Loitz, M. and Hammer, V. and Buena-Atienza, E. and Ruschil, C. and Huebener-Schmid, J. and Kowarik, M. and Salker, M.S. and Casadei, N. and Nahnsen, S. and Kremsner, P. and Ossowski, S. and Altmann, D.M. and Riess, O.

DOI: 10.1101/2022.09.12.507666

Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cells in recovered COVID-19 pregnant women

Biorxiv

Aziz, N.H.A. and Salker, M.S. and Lankapalli, A.K. and Shafiee, M.N. and Kocak, E. and Pal, S.S. and Khalid, O. and Kasim, N.M. and Kalok, A. and Fuad, N.A. and Ossowski, S. and Casadei, N. and Brucker, S.Y. and Riess, O. and Singh, Y.

DOI: 10.1101/2022.08.18.504053

Molecular and Physiological Aspects of SARS-CoV-2 Infection in Women and Pregnancy

Frontiers in Global Women S Health

Liu, A. and Raja xavier, J. and Singh, Y. and Brucker, S.Y. and Salker, M.S.

DOI: 10.3389/fgwh.2022.756362

Marker-free imaging of a-Synuclein aggregates in a rat model of Parkinsons disease using Raman microspectroscopy

Fide Sevgi and Eva M Brauchle and Daniel A Carvajal Berrio and Katja Schenke-Layland and Nicolas Casadei and Madhuri S Salker and Olaf Riess and Yogesh Singh

DOI: 10.1101/2021.02.02.429468

02 / 2021

Imaging of a-Synuclein Aggregates in a Rat Model of Parkinsons Disease Using Raman Microspectroscopy

Frontiers in Cell and Developmental Biology

Sevgi, F. and Brauchle, E.M. and Carvajal Berrio, D.A. and Schenke-Layland, K. and Casadei, N. and Salker, M.S. and Riess, O. and Singh, Y.

DOI: 10.3389/fcell.2021.664365

Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function

Frontiers in Nutrition

Singh, Y. and Salker, M.S. and Lang, F.

DOI: 10.3389/fnut.2020.616934

The putative role of 1,25(OH)2D3 in the association of milk consumption and Parkinsons disease

Neurosignals

Lang, F. and Ma, K. and Leibrock, C.B. and Salker, M.S. and Singh, Y.

DOI: 10.33594/000000321

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells

Yogesh Singh and Christoph Trautwein and Rolf Fendel and Naomi Krickeberg and Georgy Berezhnoy and Rosi Bissinger and Stephan Ossowski and Madhuri S. Salker and Nicolas Casadei and Olaf Riess

DOI: 10.1101/2020.09.04.282780

09 / 2020

Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells

Molecular Nutrition and Food Research

Alauddin, M. and Okumura, T. and Rajaxavier, J. and Khozooei, S. and P{\"o}schel, S. and Takeda, S. and Singh, Y. and Brucker, S.Y. and Wallwiener, D. and Koch, A. and Salker, M.S.

DOI: 10.1002/mnfr.201900390

Annexin A7 Regulates Endometrial Receptivity

Frontiers in Cell and Developmental Biology

Alauddin, M. and Salker, M.S. and Umbach, A.T. and Rajaxavier, J. and Okumura, T. and Singh, Y. and Wagner, A. and Brucker, S.Y. and Wallwiener, D. and Brosens, J.J. and Lang, F.

DOI: 10.3389/fcell.2020.00770

Glucose transport in lymphocytes

Pflugers Archiv European Journal of Physiology

Lang, F. and Singh, Y. and Salker, M.S. and Ma, K. and Pandyra, A.A. and Lang, P.A. and Lang, K.S.

DOI: 10.1007/s00424-020-02416-y

LEFTY2/endometrial bleeding-associated factor up-regulates Na+ Coupled Glucose Transporter SGLT1 expression and Glycogen Accumulation in Endometrial Cancer Cells

Plos One

Zeng, N. and Okumura, T. and Alauddin, M. and Khozooei, S. and Rajaxavier, J. and Zhang, S. and Singh, Y. and Shi, B. and Brucker, S.Y. and Wallwiener, D. and Takeda, S. and Lang, F. and Salker, M.S.

DOI: 10.1371/journal.pone.0230044

DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs)

Scientific Reports

Singh, Y. and Trautwein, C. and Dhariwal, A. and Salker, M.S. and Alauddin, M. and Zizmare, L. and Pelzl, L. and Feger, M. and Admard, J. and Casadei, N. and F{\"o}ller, M. and Pachauri, V. and Park, D.S. and Mak, T.W. and Frick, J.-S. and Wallwiener, D. and Brucker, S.Y. and Lang, F. and Riess, O.

DOI: 10.1038/s41598-020-72903-w

Point-of-care-ready nanoscale ISFET arrays for sub-picomolar detection of cytokines in cell cultures

Analytical and Bioanalytical Chemistry

Rani, D. and Singh, Y. and Salker, M. and Vu, X.T. and Ingebrandt, S. and Pachauri, V.

DOI: 10.1007/s00216-020-02820-4

The Enigmatic Role of Serum & Glucocorticoid Inducible Kinase 1 in the Endometrium

Frontiers in Cell and Developmental Biology

Lang, F. and Rajaxavier, J. and Singh, Y. and Brucker, S.Y. and Salker, M.S.

DOI: 10.3389/fcell.2020.556543

DJ-1 (Park7) affects the gut microbiome, metabolites and development of Innate Lymphoid cells (ILCs)

Biorxiv

Singh, Y. and Trautwein, C. and Dhariwal, A. and Salker, M.S. and Alauddin, M. and Zigmare, L. and Pelzl, L. and Feger, M. and Matthes, J. and Casadei, N. and F{\"o}ller, M. and Pachauri, V. and Park, D.S. and Mak, T.W. and Frick, J.S. and Wallwiener, D. and Brucker, S.Y. and Lang, F. and Riess, O.

DOI: 10.1101/776005

Raman imaging of a-synuclein aggregates in a rat model of Parkinson's disease

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Brauchle, E. and Sevgi, F. and Berrio, D.C. and Schenke-Layland, K. and Casadei, N. and Riess, O. and Salker, M.S. and Singh, Y.

DOI: 10.1117/12.2509751

Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca2+ Entry in T Cells by Regulating miR-10a-5p

Frontiers in Immunology

Zhang, S. and Al-Maghout, T. and Cao, H. and Pelzl, L. and Salker, M.S. and Veldhoen, M. and Cheng, A. and Lang, F. and Singh, Y.

DOI: 10.3389/fimmu.2019.01737

Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival

Apoptosis

Bissinger, R. and Lang, E. and Gonzalez-Menendez, I. and Quintanilla-Martinez, L. and Ghashghaeinia, M. and Pelzl, L. and Sukkar, B. and Bhuyan, A.A.M. and Salker, M.S. and Singh, Y. and Fehrenbacher, B. and Fakhri, H. and Umbach, A.T. and Schaller, M. and Qadri, S.M. and Lang, F.

DOI: 10.1007/s10495-018-1481-8

LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry

Journal of Molecular Medicine

Salker, M.S. and Singh, Y. and Durairaj, R.R.P. and Yan, J. and Alauddin, M. and Zeng, N. and Steel, J.H. and Zhang, S. and Nautiyal, J. and Webster, Z. and Brucker, S.Y. and Wallwiener, D. and Anne Croy, B. and Brosens, J.J. and Lang, F.

DOI: 10.1007/s00109-017-1610-9

Epigallocatechin-3-gallate (EGCG) up-regulates miR-15b expression thus attenuating store operated calcium entry (SOCE) into murine CD4+ T cells and human leukaemic T cell lymphoblasts

Oncotarget

Zhang, S. and Al-Maghout, T. and Bissinger, R. and Zeng, N. and Pelzl, L. and Salker, M.S. and Cheng, A. and Singh, Y. and Lang, F.

DOI: 10.18632/oncotarget.20032

Negative effect of ellagic acid on cytosolic ph regulation and glycolytic flux in human endometrial cancer cells

Cellular Physiology and Biochemistry

Abdelazeem, K.N.M. and Singh, Y. and Lang, F. and Salker, M.S.

DOI: 10.1159/000475655

Enhanced Reactive Oxygen Species Production, Acidic Cytosolic pH and Upregulated Na + /H + Exchanger (NHE) in Dicer Deficient CD4 + T Cells

Cellular Physiology and Biochemistry

Singh, Y. and Zhou, Y. and Zhang, S. and Abdelazeem, K.N.M. and Elvira, B. and Salker, M.S. and Lang, F.

DOI: 10.1159/000479201

1a,25(OH) 2 D 3 Sensitive Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Ishikawa Cells

Cellular Physiology and Biochemistry

Zeng, N. and Zhou, Y. and Zhang, S. and Singh, Y. and Shi, B. and Salker, M.S. and Lang, F.

DOI: 10.1159/000458427

Decidualization is Impaired in Endometrial Stromal Cells from Uterine Rudiments in Mayer-Rokitansky-Kster-Hauser Syndrome

Cellular Physiology and Biochemistry

Brucker, S.Y. and Eisenbeis, S. and K{\"o}nig, J. and Lamy, M. and Salker, M.S. and Zeng, N. and Seeger, H. and Henes, M. and Sch{\"o}ller, D. and Sch{\"o}nfisch, B. and Staebler, A. and Taran, F.-A. and Wallwiener, D. and Rall, K.

DOI: 10.1159/000464116

DJ-1/Park7 Sensitive Na+/H+ Exchanger 1 (NHE1) in CD4+ T Cells

Journal of Cellular Physiology

Zhou, Y. and Shi, X. and Chen, H. and Zhang, S. and Salker, M.S. and Mack, A.F. and F{\"o}ller, M. and Mak, T.W. and Singh, Y. and Lang, F.

DOI: 10.1002/jcp.25516

SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice

Cellular Physiology and Biochemistry

Sharma, P. and Khairnar, V. and Maduni?, I.V. and Singh, Y. and Pandyra, A. and Salker, M.S. and Koepsell, H. and Saboli?, I. and Lang, F. and Lang, P.A. and Lang, K.S.

DOI: 10.1159/000479197

Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy

Scientific Reports

Salker, M.S. and Singh, Y. and Zeng, N. and Chen, H. and Zhang, S. and Umbach, A.T. and Fakhri, H. and Kohlhofer, U. and Quintanilla-Martinez, L. and Durairaj, R.R.P. and Barros, F.S.V. and Vrljicak, P. and Ott, S. and Brucker, S.Y. and Wallwiener, D. and Maduni?, I.V. and Breljak, D. and Saboli?, I. and Koepsell, H. and Brosens, J.J. and Lang, F.

DOI: 10.1038/s41598-017-11674-3

Downregulation of endometrial mesenchymal marker SUSD2 causes cell senescence and cell death in endometrial carcinoma cells

PLoS ONE

Zhang, S. and Zeng, N. and Alowayed, N. and Singh, Y. and Cheng, A. and Lang, F. and Salker, M.S.

DOI: 10.1371/journal.pone.0183681

1a,25(OH) 2 D 3 Induces Actin Depolymerization in Endometrial Carcinoma Cells by Targeting RAC1 and PAK1

Cellular Physiology and Biochemistry

Zeng, N. and Salker, M.S. and Zhang, S. and Singh, Y. and Shi, B. and Stournaras, C. and Lang, F.

DOI: 10.1159/000453197

Prolyl hydroxylase 3 (PHD3) expression augments the development of regulatory T cells

Molecular Immunology

Singh, Y. and Shi, X. and Zhang, S. and Umbach, A.T. and Chen, H. and Salker, M.S. and Lang, F.

DOI: 10.1016/j.molimm.2016.06.003

Role of Dicer Enzyme in the Regulation of Store Operated Calcium Entry (SOCE) in CD4 + T Cells

Cellular Physiology and Biochemistry

Zhang, S. and Al-Maghout, T. and Zhou, Y. and Bissinger, R. and Abousaab, A. and Salker, M.S. and Pelzl, L. and Cobb, B.S. and Cheng, A. and Singh, Y. and Lang, F.

DOI: 10.1159/000447840

Activation of SGK1 in Endometrial Epithelial Cells in Response to PI3K/AKT Inhibition Impairs Embryo Implantation

Cellular Physiology and Biochemistry

Salker, M.S. and Steel, J.H. and Hosseinzadeh, Z. and Nautiyal, J. and Webster, Z. and Singh, Y. and Brucker, S. and Lang, F. and Brosens, J.J.

DOI: 10.1159/000447903

Up-regulation of FGF23 release by aldosterone

Biochemical and Biophysical Research Communications

Zhang, B. and Umbach, A.T. and Chen, H. and Yan, J. and Fakhri, H. and Fajol, A. and Salker, M.S. and Spichtig, D. and Daryadel, A. and Wagner, C.A. and F{\"o}ller, M. and Lang, F.

DOI: 10.1016/j.bbrc.2016.01.034

-Klotho as a Negative Regulator of the Peptide Transporters PEPT1 and PEPT2

Cellular Physiology and Biochemistry

Abousaab, A. and Warsi, J. and Salker, M.S. and Lang, F.

DOI: 10.1159/000453146

NFB-sensitive Orai1 expression in the regulation of FGF23 release

Journal of Molecular Medicine

Zhang, B. and Yan, J. and Umbach, A.T. and Fakhri, H. and Fajol, A. and Schmidt, S. and Salker, M.S. and Chen, H. and Alexander, D. and Spichtig, D. and Daryadel, A. and Wagner, C.A. and F{\"o}ller, M. and Lang, F.

DOI: 10.1007/s00109-015-1370-3

LEFTY2 Controls Migration of Human Endometrial Cancer Cells via Focal Adhesion Kinase Activity (FAK) and miRNA-200a

Cellular Physiology and Biochemistry

Alowayed, N. and Salker, M.S. and Zeng, N. and Singh, Y. and Lang, F.

DOI: 10.1159/000447792

LEFTYA Activates the Epithelial Na + Channel (ENaC) in Endometrial Cells via Serum and Glucocorticoid Inducible Kinase SGK1

Cellular Physiology and Biochemistry

Salker, M.S. and Hosseinzadeh, Z. and Alowayed, N. and Zeng, N. and Umbach, A.T. and Webster, Z. and Singh, Y. and Brosens, J.J. and Lang, F.

DOI: 10.1159/000447834

Alkaline cytosolic ph and high sodium hydrogen exchanger 1 (NHE1) activity in Th9 cells

Journal of Biological Chemistry

Singh, Y. and Zhou, Y. and Shi, X. and Zhang, S. and Umbach, A.T. and Salker, M.S. and Lang, K.S. and Lang, F.

DOI: 10.1074/jbc.M116.730259

Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development

Cellular Physiology and Biochemistry

Zhou, Y. and Salker, M.S. and Walker, B. and M{\"u}nzer, P. and Borst, O. and Gawaz, M. and Gulbins, E. and Singh, Y. and Lang, F.

DOI: 10.1159/000447806

LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells

Scientific Reports

Salker, M.S. and Schierbaum, N. and Alowayed, N. and Singh, Y. and Mack, A.F. and Stournaras, C. and Sch{\"a}ffer, T.E. and Lang, F.

DOI: 10.1038/srep29370

Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2

Scientific Reports

Lang, E. and Bissinger, R. and Fajol, A. and Salker, M.S. and Singh, Y. and Zelenak, C. and Ghashghaeinia, M. and Gu, S. and Jilani, K. and Lupescu, A. and Reyskens, K.M.S.E. and Ackermann, T.F. and F{\"o}ller, M. and Schleicher, E. and Sheffield, W.P. and Arthur, J.S.C. and Lang, F. and Qadri, S.M.

DOI: 10.1038/srep17316

LeftyA sensitive cytosolic pH regulation and glycolytic flux in Ishikawa human endometrial cancer cells

Biochemical and Biophysical Research Communications

Salker, M.S. and Zhou, Y. and Singh, Y. and Brosens, J. and Lang, F.

DOI: 10.1016/j.bbrc.2015.03.120

Enhanced suicidal erythrocyte death contributing to anemia in the elderly

Cellular Physiology and Biochemistry

Lupescu, A. and Bissinger, R. and Goebel, T. and Salker, M.S. and Alzoubi, K. and Liu, G. and Chirigiu, L. and Mack, A.F. and Qadri, S.M. and Lang, F.

DOI: 10.1159/000430137

SPAK sensitive regulation of the epithelial Na+ channel ENaC

Kidney and Blood Pressure Research

Ahmed, M. and Salker, M.S. and Elvira, B. and Umbach, A.T. and Fakhri, H. and Saeed, A.M. and Shumilina, E. and Hosseinzadeh, Z. and Lang, F.

DOI: 10.1159/000368509

SPAK and OSR1 sensitivity of excitatory amino acid transporter EAAT3

Nephron

Borr{\'a}s, J. and Salker, M.S. and Elvira, B. and Warsi, J. and Fezai, M. and Hoseinzadeh, Z. and Lang, F.

DOI: 10.1159/000433567

Lithium-Sensitive Store-Operated Ca2+ Entry in the Regulation of FGF23 Release

NeuroSignals

Zhang, B. and Yan, J. and Schmidt, S. and Salker, M.S. and Alexander, D. and F{\"o}ller, M. and Lang, F.

DOI: 10.1159/000442602

Differential effect of DJ-1/PARK7 on development of natural and induced regulatory T cells

Scientific Reports

Singh, Y. and Chen, H. and Zhou, Y. and F{\"o}ller, M. and Mak, T.W. and Salker, M.S. and Lang, F.

DOI: 10.1038/srep17723

Uterine selection of human embryos at implantation

Scientific Reports

Brosens, J.J. and Salker, M.S. and Teklenburg, G. and Nautiyal, J. and Salter, S. and Lucas, E.S. and Steel, J.H. and Christian, M. and Chan, Y.-W. and Boomsma, C.M. and Moore, J.D. and Hartshorne, G.M. and ?u?urovi?, S. and Mulac-Jericevic, B. and Heijnen, C.J. and Quenby, S. and Groot Koerkamp, M.J. and Holstege, F.C.P. and Shmygol, A. and Macklon, N.S.

DOI: 10.1038/srep03894

SPAK dependent regulation of peptide transporters PEPT1 and PEPT2

Kidney and Blood Pressure Research

Warsi, J. and Dong, L. and Elvira, B. and Salker, M.S. and Shumilina, E. and Hosseinzadeh, Z. and Lang, F.

DOI: 10.1159/000368451

Induction of 11-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells

Molecular Endocrinology

Kuroda, K. and Venkatakrishnan, R. and Salker, M.S. and Lucas, E.S. and Shaheen, F. and Kuroda, M. and Blanks, A. and Christian, M. and Quenby, S. and Brosens, J.J.

DOI: 10.1210/me.2012-1247

Reprint of: Uterine plasticity and reproductive fitness

Reproductive BioMedicine Online

Lucas, E.S. and Salker, M.S. and Brosens, J.J.

DOI: 10.1016/j.rbmo.2013.10.003

Uterine plasticity and reproductive fitness

Reproductive BioMedicine Online

Lucas, E.S. and Salker, M.S. and Brosens, J.J.

DOI: 10.1016/j.rbmo.2013.06.012

SGK1: A therapeutic target to prevent reproductive failure?

Expert Review of Obstetrics and Gynecology

Salker, M.S. and Quenby, S. and Brosens, J.J.

DOI: 10.1586/eog.12.1

Molecular aspects of implantation failure

Biochimica et Biophysica Acta - Molecular Basis of Disease

Koot, Y.E.M. and Teklenburg, G. and Salker, M.S. and Brosens, J.J. and Macklon, N.S.

DOI: 10.1016/j.bbadis.2012.05.017

Disordered IL-33/ST2 Activation in Decidualizing Stromal Cells Prolongs Uterine Receptivity in Women with Recurrent Pregnancy Loss

PLoS ONE

Salker, M.S. and Nautiyal, J. and Steel, J.H. and Webster, Z. and ?u?urovi?, S. and Nicou, M. and Singh, Y. and Lucas, E.S. and Murakami, K. and Chan, Y.-W. and James, S. and Abdallah, Y. and Christian, M. and Croy, B.A. and Mulac-Jericevic, B. and Quenby, S. and Brosens, J.J.

DOI: 10.1371/journal.pone.0052252

Deregulation of the serum-and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure

Nature Medicine

Salker, M.S. and Christian, M. and Steel, J.H. and Nautiyal, J. and Lavery, S. and Trew, G. and Webster, Z. and Al-Sabbagh, M. and Puchchakayala, G. and F{\"o}ller, M. and Landles, C. and Sharkey, A.M. and Quenby, S. and Aplin, J.D. and Regan, L. and Lang, F. and Brosens, J.J.

DOI: 10.1038/nm.2498

The molecular basis of recurrent pregnancy loss: Impaired natural embryo selection

Molecular Human Reproduction

Teklenburg, G. and Salker, M. and Heijnen, C. and Macklon, N.S. and Brosens, J.J.

DOI: 10.1093/molehr/gaq079

Natural selection of human embryos: Impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss

PLoS ONE

Salker, M. and Teklenburg, G. and Molokhia, M. and Lavery, S. and Trew, G. and Aojanepong, T. and Mardon, H.J. and Lokugamage, A.U. and Rai, R. and Landles, C. and Roelen, B.A.J. and Quenby, S. and Kuijk, E.W. and Kavelaars, A. and Heijnen, C.J. and Regan, L. and Macklon, N.S. and Brosens, J.J.

DOI: 10.1371/journal.pone.0010287

Natural selection of human embryos: Decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation

PLoS ONE

Teklenburg, G. and Salker, M. and Molokhia, M. and Lavery, S. and Trew, G. and Aojanepong, T. and Mardon, H.J. and Lokugamage, A.U. and Rai, R. and Landles, C. and Roelen, B.A.J. and Quenby, S. and Kuijk, E.W. and Kavelaars, A. and Heijnen, C.J. and Regan, L. and Brosens, J.J. and Macklon, N.S.

DOI: 10.1371/journal.pone.0010258

Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis

Molecular Human Reproduction

Brosens, J.J. and Hodgetts, A. and Feroze-Zaidi, F. and Sherwin, J.R.A. and Fusi, L. and Salker, M.S. and Higham, J. and Rose, G.L. and Kajihara, T. and Young, S.L. and Lessey, B.A. and Henriet, P. and Langford, P.R. and Fazleabas, A.T.

DOI: 10.1093/molehr/gap108

Role and regulation of the serum- and glucocorticoid-regulated kinase 1 in fertile and infertile human endometrium

Endocrinology

Feroze-Zaidi, F. and Fusi, L. and Takano, M. and Higham, J. and Salker, M.S. and Goto, T. and Edassery, S. and Klingel, K. and Boini, K.M. and Palmada, M. and Kamps, R. and Groothuis, P.G. and Lam, E.W.-F. and Smith, S.K. and Lang, F. and Sharkey, A.M. and Brosens, J.J.

DOI: 10.1210/en.2007-0659

Closure of the posterior neuropore in the vl mutant mouse.

Anatomy and embryology

DOI: 10.1007/bf00305044 PubMed: 3223614

01 / 1988

Developing ML prediction models for the identification of adverse maternal and neonatal outcomes

Stillbirth is often referred to as a ‘silent epidemic’ accounting for the fifth leading global cause of deaths (when compared with causes of death in all ages)-outranking cancer, tuberculosis (TB) and HIV. That is: losing 5 precious babies each minute. The rate in Canada remains high at 8.9 per 1,000 births- which has not reduced in 20 years. Stillbirths including maternal death rates are significantly higher for First Nations and Inuit populations in Canada compared to non-Aboriginal populations and, in low- and middle-income countries (LMICs), mainly related to lack of health infrastructure and clinical monitoring during pregnancy. Despite of such socio-economic disparities most cases are associated with a missed or delayed diagnosis. Therefore, there is an urgent critical need to discover novel biomarkers (prognostic and predictive) that enable diagnosis of adverse gestational outcomes (APO) earlier.

Evaluating the endometrial microenvironment stiffness and pre-eclampsia

Pregnancy is dependent on the transformation of the endometrium, a process driven by the differentiation of endometrial stromal cells (EnSCs) into specialized decidual cells. The decidua contributes to early nutrient exchange, production of cytokines, and growth factors as well as supports the development of new blood vessels, modulates extravillous trophoblast (EVT) invasion, and acts as a protective barrier against infections and maternal host immune responses.

Disturbances in the uterine microenvironment are associated with miscarriages and third-trimester perinatal morbidity and mortality caused by pre-eclampsia (PE) and intrauterine growth restriction, small-for-gestational age, pre-term birth, and stillbirth. It is increasingly evident that abnormal levels of inflammatory and growth/signaling factors produced in the decidua during early pregnancy play a decisive role in the deregulation of the local microenvironment leading to several disorders of pregnancy. Our research investigates how impaired cytoskeletal rearrangement and stiffness participates in the pathophysiology of pre-eclampsia.

Evaluation of new point-of-care tools for use in pregnancy

Rapid and frequent screening of molecules is necessary for precise interventions in severe pathophysiological conditions. We are evaluating the use of point-of-care-ready bioanalytical platforms for screening of multiplexed-cytokines based on one-dimensional ion-sensitive field-effect transistors arrays (nanoISFETs) of silicon fabricated at wafer-scale via nanoimprint lithography in collaboration with RWTH, Aachen, Germany.

Grants

Principal Applicant. Margarete von Wrangell-Habilitationsprogramm für Frauen. Funding Source: BMBF and EU Funding

Principal Investigator. InUtero; Stillbirth prediction. Funding Source: Wellcome Leap

Principal Applicant. Athene Grant for Women Scientists. Funding Source: Federal Ministry of Education and Research (BMBF)

Principal Applicant. Role of NFAT5 in the endometrium. Funding Source: Else Kröner-Fresenius Foundation

Principal Applicant. Placental organoids and COVID-19 infection. Funding Source: Ferring Pharmaceuticals

Honours & Awards

Travel Award, Paris - European Molecular Biology Laboratory meeting

Study Exchange Program Prize - Juntendo University School of Medicine

Citizenship Award - London

2023 - Lindau Nobel Laurate Meeting Attendee

2019 - Finalist for Maria Gräfin von Linden Prize

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

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