BCCHR Researchers Find a Researcher

Mark Chilvers

MRCPCH, MD, BSc, MBChB

Investigator, BC Children's Hospital

Respiratory

Over the last 15 years I have developed a research interest into non-CF Bronchiectasis. This focused primarily on primary ciliary dyskinesia. I developed a new method for the evaluation of function of the microscopic hairs (cilia) which line the airways of the lung. This has been standardized and now used as an accepted method for the diagnosis of primary ciliary dyskinesia and research platform.

Cystic Fibrosis

Cystic Fibrosis (CF) research is another significant research area. I am the PI on several clinical trials looking at new medications in CF patients.

I coordinate the CF clinic multidisciplinary research program and this is promoting research into nursing, physiotherapy, pharmacy and dietetic issues within CF. Current themes are transitional care to adulthood; physiotherapy interventions; location of CF care and outcome in adolescence and adherence to medication. We work closely with the adult CF clinic at St. Paul's on several joint projects.

Academic Affiliations

Clinical Associate Professor, Division of Respiratory Medicine, Department of Pediatrics, Faculty of Medicine, University of British Columbia
Research Theme: Childhood Diseases

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

(604) 875-2345 ext. 4930

mchilvers@cw.bc.ca

A Germline Heterozygous Dominant Negative IKZF2 Variant Causing Syndromic Primary Immune Regulatory Disorder and ICHAD

Journal of Clinical Immunology

Lu, H.Y. and Vaseghi-Shanjani, M. and Lam, A.J. and Sharma, M. and Mohajeri, A. and Silva, L.B.R. and Gillies, J. and Yang, G.X. and Lin, S. and Fu, M.P. and Salman, A. and Rahmanian, R. and Armstrong, L. and Halparin, J. and Yang, C.L. and Chilvers, M. and Henkelman, E. and Rehmus, W. and Morrison, D. and Setiadi, A. and Mostafavi, S. and Kobor, M.S. and Kozak, F.K. and Biggs, C.M. and van Karnebeek, C. and Hildebrand, K.J. and Levings, M.K. and Turvey, S.E.

DOI: 10.1007/s10875-025-01882-2

Vanzacaftor"tezacaftor"deutivacaftor versus elexacaftor"tezacaftor"ivacaftor in individuals with cystic fibrosis aged 12 years and older (SKYLINE Trials VX20-121-102 and VX20-121-103): results from two randomised, active-controlled, phase 3 trials

Lancet Respiratory Medicine

Keating, C. and Yonker, L.M. and Vermeulen, F. and Prais, D. and Linnemann, R.W. and Trimble, A. and Kotsimbos, T. and Mermis, J. and Braun, A.T. and O{'}Carroll, M. and Sutharsan, S. and Ramsey, B. and Mall, M.A. and Taylor-Cousar, J.L. and McKone, E.F. and Tullis, E. and Floreth, T. and Michelson, P. and Sosnay, P.R. and Nair, N. and Zahigian, R. and Martin, H. and Ahluwalia, N. and Lam, A. and Horsley, A. and Krick, S. and McCoy, K. and Goss, C. and Weiner, D. and Ren, C. and Atkinson, J. and Trimble, A. and Fortner, C. and Frederick, C. and Liou, T. and Escobar, H. and Wang, J. and Froh, D. and Chmiel, J. and Wurth, M. and Bilodeau, L. and Lapey, A. and Jain, M. and Millard, S. and Tolle, J. and Moffett, K. and Jia, S. and Brown, C. and Brown, P. and Uluer, A. and Ruddy, J. and Sears, E. and Pancham, K. and Fiel, S. and Mueller, G. and Omlor, G. and Braun, A. and Mehdi, N. and Tupayachi Ortiz, M.G. and Teneback, C. and Kremer, T. and Messore, B. and Hoppe, J. and Jain, R. and Lambert, A. and Mukadam, Z. and Calimano, F. and Daines, C. and Egan, M. and Green, D. and Keens, T. and Wilhelm, A. and Morrissey, B. and Reyes, S. and Schaeffer, D. and Wallace, J. and Callison, J. and Klingsberg, R. and Szepfalusi, Z. and Epaud, R. and Leroy, S. and Fischer Biner, R. and Moeller, A. and Salvatore, D. and Efrati, O. and Cohen-Cymberknoh, M. and Johnson, L. and Wong, J. and Gohy, S. and Gramegna, A. and Olesen, H. and Tissot, A. and Marguet, C. and Sivam, S. and Desai, M. and Waller, M. and Owens, L. and Kherani, T. and Marion, C. and Lysinger, J. and Sands, D. and Bakkeheim, E. and Chilvers, M. and Quon, B. and Lands, L. and Parkins, M. and Tremblay, F. and Maitra, A. and Casserly, B. and Staples, H. and Elidemir, O. and Chatziagorou, E. and Tirakitsoontorn, P. and Grenet, D. and Brown, S. and Linnane, B. and Nicholson, J.M. and Manika, K. and Tatopoulos, A. and Byrnes, C. and Ruppel, R. and Stahl, M. and Pressler, T. and Stehling, F. and Bagheri-Potthoff, A. and Fischer, R. and Haworth, C. and Simmonds, N. and Duckers, J. and Legg, J. and MacGregor, G. and Peckham, D. and Lee, T. and Houdouin, V. and Ramel, S. and Fajac, I. and Sermet-Gaudelus, I. and Kamphuis, L. and van der Ent, K. and Chiron, R. and Reix, P. and Van Braeckel, E. and Knoop, C. and Vanderhelst, E. and Durieu, I. and Bui, S. and Weiss, L. and Le Rouzic, O. and van der Meer, R. and Roukema, J. and Altenburg, J. and Cox, D. and Plant, B. and Williamson, M. and Robinson, P. and Wainwright, C. and Burr, L. and Henderson, D. and Mulrennan, S. and Clements, B. and Middleton, P. and Kotsimbos, T. and Taccetti, G. and Cipolli, M. and Dacco, V. and Fabrizzi, B. and Castellani, C. and Eber, E. and Appelt, D. and Studnicka, M. and De Monestrol, I. and Gilljam, M. and Sapiejka, E. and Mazurek, H. and Lindberg, U. and Engan, M. and Sauty, A. and Mankikian, J. and Epton, M. and Halasz, A. and Laki, I.

DOI: 10.1016/S2213-2600(24)00411-9

Elexacaftor/tezacaftor/ivacaftor in children aged =6 years with cystic fibrosis heterozygous for F508del and a minimal function mutation: results from a 96-week open-label extension study

European Respiratory Journal

Mall, M.A. and Wainwright, C.E. and Legg, J. and Chilvers, M. and Gartner, S. and Dittrich, A.-M. and Stehling, F. and Conner, S. and Grant, S. and Suresh, N. and Weinstock, T.G. and Davies, J.C.

DOI: 10.1183/13993003.02435-2024

Cost-Effectiveness of Infant and Maternal RSV Immunization Strategies

Medrxiv

Taleshi, J. and Paramo, M.V. and Watts, A. and Chilvers, M. and Hay Wong, J.M. and Piszczek, J. and Separovic, L. and Hu, J. and Skowronski, D. and Lavoie, P.M. and Sbihi, H.

DOI: 10.1101/2025.06.27.25330432

Standards for the care of people with cystic fibrosis; establishing and maintaining health

Journal of Cystic Fibrosis

Southern, K.W. and Addy, C. and Bell, S.C. and Bevan, A. and Borawska, U. and Brown, C. and Burgel, P.-R. and Button, B. and Castellani, C. and Chansard, A. and Chilvers, M.A. and Davies, G. and Davies, J.C. and De Boeck, K. and Declercq, D. and Doumit, M. and Drevinek, P. and Fajac, I. and Gartner, S. and Georgiopoulos, A.M. and Gursli, S. and Gramegna, A. and Hansen, C.M. and Hug, M.J. and Lammertyn, E. and Landau, E.E.C. and Langley, R. and Mayer-Hamblett, N. and Middleton, A. and Middleton, P.G. and Mielus, M. and Morrison, L. and Munck, A. and Plant, B. and Ploeger, M. and Bertrand, D.P. and Pressler, T. and Quon, B.S. and Radtke, T. and Saynor, Z.L. and Shufer, I. and Smyth, A.R. and Smith, C. and van Koningsbruggen-Rietschel, S.

DOI: 10.1016/j.jcf.2023.12.002

High-quality read-based phasing of cystic fibrosis cohort informs genetic understanding of disease modification

Human Genetics and Genomics Advances

Mastromatteo, S. and Chen, A. and Gong, J. and Lin, F. and Thiruvahindrapuram, B. and Sung, W.W.L. and Whitney, J. and Wang, Z. and Patel, R.V. and Keenan, K. and Halevy, A. and Panjwani, N. and Avolio, J. and Wang, C. and C{\^o}t{\'e}-Maurais, G. and B{\'e}gin, S. and Adam, D. and Brochiero, E. and Bjornson, C. and Chilvers, M. and Price, A. and Parkins, M. and van Wylick, R. and Mateos-Corral, D. and Hughes, D. and Smith, M.J. and Morrison, N. and Tullis, E. and Stephenson, A.L. and Wilcox, P. and Quon, B.S. and Leung, W.M. and Solomon, M. and Sun, L. and Ratjen, F. and Strug, L.J.

DOI: 10.1016/j.xhgg.2022.100156

A Phase 3, open-label, 96-week trial to study the safety, tolerability, and efficacy of tezacaftor/ivacaftor in children = 6 years of age homozygous for F508del or heterozygous for F508del and a residual function CFTR variant

Journal of Cystic Fibrosis

Sawicki, G.S. and Chilvers, M. and McNamara, J. and Naehrlich, L. and Saunders, C. and Sermet-Gaudelus, I. and Wainwright, C.E. and Ahluwalia, N. and Campbell, D. and Harris, R.S. and Paz-Diaz, H. and Shih, J.L. and Davies, J.C.

DOI: 10.1016/j.jcf.2022.02.003

High Quality Phasing Using Linked-Read Whole Genome Sequencing of Patient Cohorts Informs Genetic Understanding of Complex Traits

bioRxiv

Mastromatteo, S. and Chen, A. and Gong, J. and Lin, F. and Thiruvahindrapuram, B. and Sung, W.W.L. and Whitney, J. and Wang, Z. and Patel, R.V. and Keenan, K. and Halevy, A. and Panjwani, N. and Avolio, J. and Wang, C. and Ct-Maurais, G. and Bgin, S. and Adam, D. and Brochiero, E. and Bjornson, C. and Chilvers, M. and Price, A. and Parkins, M. and van Wylick, R. and Mateos-Corral, D. and Hughes, D. and Smith, M.J. and Morrison, N. and Tullis, E. and Stephenson, A.L. and Wilcox, P. and Quon, B.S. and Leung, W.M. and Solomon, M. and Sun, L. and Ratjen, F. and Strug, L.J.

DOI: 10.1101/2022.03.28.486092

Long-term respiratory outcomes following solid organ transplantation in children: A retrospective cohort study

Pediatric Pulmonology

Wright, M.F.A. and Blydt-Hansen, T. and Chilvers, M.A.

DOI: 10.1002/ppul.25968

Cystic fibrosis-related diabetes onset can be predicted using biomarkers measured at birth.

Genetics in medicine : official journal of the American College of Medical Genetics

Lin YC and Keenan K and Gong J and Panjwani N and Avolio J and Lin F and Adam D and Barrett P and Bgin S and Berthiaume Y and Bilodeau L and Bjornson C and Brusky J and Burgess C and Strug LJ

DOI: 10.1038/s41436-020-01073-x PubMed: 33500570

01 / 2021

Long-term safety and efficacy of lumacaftor-ivacaftor therapy in children aged 6-11 years with cystic fibrosis homozygous for the F508del-CFTR mutation: a phase 3, open-label, extension study.

The Lancet. Respiratory medicine

Chilvers MA and Davies JC and Milla C and Tian S and Han Z and Cornell AG and Owen CA and Ratjen F

DOI: 10.1016/s2213-2600(20)30517-8 PubMed: 33516285

01 / 2021

Outcomes of Cystic Fibrosis Screening"Positive Infants With Inconclusive Diagnosis at School Age

Pediatrics

Gonska, T. and Keenan, K. and Au, J. and Dupuis, A. and Chilvers, M.A. and Burgess, C. and Bjornson, C. and Fairservice, L. and Brusky, J. and Kherani, T. and Jober, A. and Kosteniuk, L. and Price, A. and Itterman, J. and Morgan, L. and Mateos-Corral, D. and Hughes, D. and Donnelly, C. and Smith, M.J. and Iqbal, S. and Arpin, J. and Reisman, J. and Hammel, J. and van Wylick, R. and Derynck, M. and Henderson, N. and Solomon, M. and Ratjen, F.

DOI: 10.1542/peds.2021-051740

Genetic evidence supports the development of SLC26A9 targeting therapies for the treatment of lung disease

medRxiv

Gong, J. and He, G. and Wang, C. and Bartlett, C. and Panjwani, N. and Mastromatteo, S. and Lin, F. and Keenan, K. and Avolio, J. and Halevy, A. and Shaw, M. and Esmaeili, M. and C{\^o}t{\'e}-Maurais, G. and Adam, D. and B{\'e}gin, S. and Bjornson, C. and Chilvers, M. and Reisman, J. and Price, A. and Parkins, M. and Van Wylick, R. and Berthiaume, Y. and Bilodeau, L. and Mateos-Corral, D. and Hughes, D. and Smith, M.J. and Morrison, N. and Brusky, J. and Tullis, E. and Stephenson, A.L. and Quon, B.S. and Wilcox, P. and Leung, W.M. and Solomon, M. and Sun, L. and Brochiero, E. and Moraes, T.J. and Gonska, T. and Ratjen, F. and Rommens, J.M. and Strug, L.J.

DOI: 10.1101/2021.10.07.21264392

Long-term safety of lumacaftor"ivacaftor in children aged 2"5 years with cystic fibrosis homozygous for the F508del-CFTR mutation: a multicentre, phase 3, open-label, extension study

The Lancet Respiratory Medicine

Hoppe, J.E. and Chilvers, M. and Ratjen, F. and McNamara, J.J. and Owen, C.A. and Tian, S. and Zahigian, R. and Cornell, A.G. and McColley, S.A.

DOI: 10.1016/S2213-2600(21)00069-2

Correction to: Cystic fibrosis"related diabetes onset can be predicted using biomarkers measured at birth (Genetics in Medicine, (2021), 23, 5, (927-933), 10.1038/s41436-020-01073-x)

Genetics in Medicine

Lin, Y.-C. and Keenan, K. and Gong, J. and Panjwani, N. and Avolio, J. and Lin, F. and Adam, D. and Barrett, P. and Bgin, S. and Berthiaume, Y. and Bilodeau, L. and Bjornson, C. and Brusky, J. and Burgess, C. and Chilvers, M. and Consunji-Araneta, R. and Ct-Maurais, G. and Dale, A. and Donnelly, C. and Fairservice, L. and Griffin, K. and Henderson, N. and Hillaby, A. and Hughes, D. and Iqbal, S. and Itterman, J. and Jackson, M. and Karlsen, E. and Kosteniuk, L. and Lazosky, L. and Leung, W. and Levesque, V. and Maille, ?. and Mateos-Corral, D. and McMahon, V. and Merjaneh, M. and Morrison, N. and Parkins, M. and Pike, J. and Price, A. and Quon, B.S. and Reisman, J. and Smith, C. and Smith, M.J. and Vadeboncoeur, N. and Veniott, D. and Viczko, T. and Wilcox, P. and van Wylick, R. and Cutting, G. and Tullis, E. and Ratjen, F. and Rommens, J.M. and Sun, L. and Solomon, M. and Stephenson, A.L. and Brochiero, E. and Blackman, S. and Corvol, H. and Strug, L.J.

DOI: 10.1038/s41436-021-01281-z

Role of transient elastography and apri in the assessment of pediatric cystic fibrosis liver disease

Canadian Liver Journal

Woolfson, J.P. and Schreiber, R.A. and Raveendran, S. and Chilvers, M. and Barker, C. and Guttman, O.R.

DOI: 10.3138/canlivj-2020-0008

Nasal Brushing Sampling and Processing using Digital High Speed Ciliary Videomicroscopy - Adaptation for the COVID-19 Pandemic.

Journal of visualized experiments : JoVE

Bricmont N and Benchimol L and Poirrier AL and Grignet C and Seaton C and Chilvers MA and Seghaye MC and Louis R and Lefebvre P and Kempeneers C

DOI: 10.3791/61949 PubMed: 33226018

11 / 2020

Factors influencing clinical trial participation for adult and pediatric patients with cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Lee M and Hu XY and Desai S and Kwong E and Fu J and Flores E and Lazosky L and Wilcox PG and Mcllwaine M and Chilvers M and Yang C and Rayment JH and Quon BS

DOI: 10.1016/j.jcf.2020.08.019 PubMed: 32900673

09 / 2020

Matrix-assisted laser desorption/ionization time-of-flight MS for the accurate identification of Burkholderia cepacia complex and Burkholderia gladioli in the clinical microbiology laboratory

Journal of Medical Microbiology

Kendrew S. K. Wong and Suk Dhaliwal and Jennifer Bilawka and Jocelyn A. Srigley and Sylvie Champagne and Marc G. Romney and Peter Tilley and Manish Sadarangani and James E. A. Zlosnik and Mark A. Chilvers

DOI: 10.1099/jmm.0.001223

08 / 2020

Performance of a three-tier (IRT-DNA-IRT) cystic fibrosis screening algorithm in British Columbia

International Journal of Neonatal Screening

Sinclair, G. and McMahon, V. and Schellenberg, A. and Nelson, T.N. and Chilvers, M. and Vallance, H.

DOI: 10.3390/ijns6020046

Epidemiology of burkholderia infections in people with cystic fibrosis in Canada between 2000 and 2017

Annals of the American Thoracic Society

Zlosnik, J.E.A. and Henry, D.A. and Hird, T.J. and Hickman, R. and Campbell, M. and Cabrera, A. and Chiavegatti, G.L. and Chilvers, M.A. and Sadarangani, M.

DOI: 10.1513/AnnalsATS.201906-443OC

Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial

The Lancet Respiratory Medicine

DOI: 10.1016/s2213-2600(19)30187-0

09 / 2019

A phase 3 study of tezacaftor in combination with ivacaftor in children aged 6 through 11years with cystic fibrosis

Journal of Cystic Fibrosis

Walker, S. and Flume, P. and McNamara, J. and Solomon, M. and Chilvers, M. and Chmiel, J. and Harris, R.S. and Haseltine, E. and Stiles, D. and Li, C. and Ahluwalia, N. and Zhou, H. and Owen, C.A. and Sawicki, G.

DOI: 10.1016/j.jcf.2019.06.009

An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2"5years (KLIMB)

Journal of Cystic Fibrosis

Rosenfeld, M. and Cunningham, S. and Harris, W.T. and Lapey, A. and Regelmann, W.E. and Sawicki, G.S. and Southern, K.W. and Chilvers, M. and Higgins, M. and Tian, S. and Cooke, J. and Davies, J.C.

DOI: 10.1016/j.jcf.2019.03.009

Ciliary functional analysis: Beating a path towards standardization

Pediatric Pulmonology

Kempeneers, C. and Seaton, C. and Garcia Espinosa, B. and Chilvers, M.A.

DOI: 10.1002/ppul.24439

Immunoreactive trypsinogen levels in newborn screened infants with an inconclusive diagnosis of cystic fibrosis

BMC Pediatrics

Ooi, C.Y. and Sutherland, R. and Castellani, C. and Keenan, K. and Boland, M. and Reisman, J. and Bjornson, C. and Chilvers, M.A. and Van Wylick, R. and Kent, S. and Price, A. and Mateos-Corral, D. and Hughes, D. and Solomon, M. and Zuberbuhler, P. and Brusky, J. and Durie, P.R. and Ratjen, F. and Gonska, T.

DOI: 10.1186/s12887-019-1756-4

An investigation into biomarkers for the diagnosis of ABPA and aspergillus disease in cystic fibrosis

Pediatric Pulmonology

Keown, K. and Abbott, S. and Kuzeljevic, B. and Rayment, J.H. and Chilvers, M.A. and Yang, C.L.

DOI: 10.1002/ppul.24465

Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.

American journal of respiratory and critical care medicine

Shapiro AJ and Davis SD and Polineni D and Manion M and Rosenfeld M and Dell SD and Chilvers MA and Ferkol TW and Zariwala MA and Sagel SD and Josephson M and Morgan L and Yilmaz O and American Thoracic Society Assembly on Pediatrics

DOI: 10.1164/rccm.201805-0819st PubMed: 29905515

06 / 2018

To beat, or not to beat, that is question! The spectrum of ciliopathies

Pediatric Pulmonology

Kempeneers, C. and Chilvers, M.A.

DOI: 10.1002/ppul.24078

Epidemiology of clonal pseudomonas aeruginosa infection in a canadian cystic fibrosis population

Annals of the American Thoracic Society

Middleton, M.A. and Layeghifard, M. and Klingel, M. and Stanojevic, S. and Yau, Y.C.W. and Zlosnik, J.E.A. and Coriati, A. and Ratjen, F.A. and Tullis, E.D. and Stephenson, A. and Wilcox, P. and Freitag, A. and Chilvers, M. and McKinney, M. and Lavoie, A. and Wang, P.W. and Guttman, D.S. and Waters, V.J.

DOI: 10.1513/AnnalsATS.201801-007OC

Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial.

The Lancet. Respiratory medicine

Ratjen F and Hug C and Marigowda G and Tian S and Huang X and Stanojevic S and Milla CE and Robinson PD and Waltz D and Davies JC and VX14-809-109 investigator group

DOI: 10.1016/s2213-2600(17)30215-1 PubMed: 28606620

06 / 2017

Response

Chest

Kempeneers, C. and Seaton, C. and Chilvers, M.A.

DOI: 10.1016/j.chest.2017.08.1177

Variation of Ciliary Beat Pattern in Three Different Beating Planes in Healthy Subjects

Chest

Kempeneers, C. and Seaton, C. and Chilvers, M.A.

DOI: 10.1016/j.chest.2016.09.015

Adverse events following live-attenuated intranasal influenza vaccination of children with cystic fibrosis: Results from two influenza seasons

Vaccine

Boikos, C. and Joseph, L. and Scheifele, D. and Lands, L.C. and De Serres, G. and Papenburg, J. and Winters, N. and Chilvers, M. and Quach, C.

DOI: 10.1016/j.vaccine.2017.07.068

Viral interference and the live-attenuated intranasal influenza vaccine: Results from a pediatric cohort with cystic fibrosis

Human Vaccines and Immunotherapeutics

Boikos, C. and Papenburg, J. and Martineau, C. and Joseph, L. and Scheifele, D. and Chilvers, M. and Lands, L.C. and De Serres, G. and Quach, C.

DOI: 10.1080/21645515.2017.1287641

Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2-5 years with cystic fibrosis and a CFTR gating mutation (KIWI): an open-label, single-arm study.

The Lancet. Respiratory medicine

Davies JC and Cunningham S and Harris WT and Lapey A and Regelmann WE and Sawicki GS and Southern KW and Robertson S and Green Y and Cooke J and Rosenfeld M and KIWI Study Group

DOI: 10.1016/s2213-2600(15)00545-7 PubMed: 26803277

01 / 2016

Influenza virus detection following administration of live-attenuated intranasal influenza vaccine in children with cystic fibrosis and their healthy siblings

Open Forum Infectious Diseases

Boikos, C. and Joseph, L. and Martineau, C. and Papenburg, J. and Scheifele, D. and Lands, L.C. and De Serres, G. and Chilvers, M. and Quach, C.

DOI: 10.1093/ofid/ofw187

Dornase alfa for cystic fibrosis

Cochrane Database of Systematic Reviews

Yang, C. and Chilvers, M. and Montgomery, M. and Nolan, S.J.

DOI: 10.1002/14651858.CD001127.pub3

Inconclusive Diagnosis of Cystic Fibrosis After Newborn Screening

PEDIATRICS

DOI: 10.1542/peds.2014-2081

06 / 2015

Evaluation of a multidimensional cystic fibrosis transition program: A quality improvement initiative

Journal of Pediatric Nursing

Gravelle, A.M. and Paone, M. and Davidson, A.G.F. and Chilvers, M.A.

DOI: 10.1016/j.pedn.2014.06.011

Factors associated with response to treatment of pulmonary exacerbations in cystic fibrosis patients

Journal of Cystic Fibrosis

Waters, V.J. and Stanojevic, S. and Sonneveld, N. and Klingel, M. and Grasemann, H. and Yau, Y.C.W. and Tullis, E. and Wilcox, P. and Freitag, A. and Chilvers, M. and Ratjen, F.A.

DOI: 10.1016/j.jcf.2015.01.007

Casting a look at pediatric plastic bronchitis

International Journal of Pediatric Otorhinolaryngology

Jasinovic, T. and Kozak, F.K. and Moxham, J.P. and Chilvers, M. and Wensley, D. and Seear, M. and Campbell, A. and Ludemann, J.P.

DOI: 10.1016/j.ijporl.2015.07.011

Burkholderia species infections in patients with cystic fibrosis in British Columbia, Canada: 30 years' experience

Annals of the American Thoracic Society

Zlosnik, J.E.A. and Zhou, G. and Brant, R. and Henry, D.A. and Hird, T.J. and Mahenthiralingam, E. and Chilvers, M.A. and Wilcox, P. and Speert, D.P.

DOI: 10.1513/AnnalsATS.201408-395OC

Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients

Journal of Cystic Fibrosis

Yau, Y.C.W. and Ratjen, F. and Tullis, E. and Wilcox, P. and Freitag, A. and Chilvers, M. and Grasemann, H. and Zlosnik, J. and Speert, D. and Corey, M. and Stanojevic, S. and Matukas, L. and Leahy, T.R. and Shih, S. and Waters, V.

DOI: 10.1016/j.jcf.2014.09.013

Surgical masks reduce airborne spread of Pseudomonas aeruginosa in colonized patients with cystic fibrosis

American Journal of Respiratory and Critical Care Medicine

Driessche, K.V. and Hens, N. and Tilley, P. and Quon, B.S. and Chilvers, M.A. and De Groot, R. and Cotton, M.F. and Marais, B.J. and Speert, D.P. and Zlosnik, J.E.A.

DOI: 10.1164/rccm.201503-0481LE

Use of the SNOT-22 and UPSIT to appropriately select pediatric patients with cystic fibrosis who should be referred to an otolaryngologist: Cross-sectional study

JAMA Otolaryngology - Head and Neck Surgery

Thamboo, A. and Dar Santos, R.C. and Naidoo, L. and Rahmanian, R. and Chilvers, M.A. and Chadha, N.K.

DOI: 10.1001/jamaoto.2014.1650

In need of a patch UP: Recurrent congenital diaphragmatic hernia presenting with a large pleural effusion

Journal of Pediatric Surgery Case Reports

Shariff, F. and McDougall, C.M. and Chilvers, M.A. and Butterworth, S.A.

DOI: 10.1016/j.epsc.2014.09.008

Efficacy and safety of ivacaftor in patients aged 6 to 11 years with cystic fibrosis with a G551D mutation

American Journal of Respiratory and Critical Care Medicine

Davies, J.C. and Wainwright, C.E. and Canny, G.J. and Chilvers, M.A. and Howenstine, M.S. and Munck, A. and Mainz, J.G. and Rodriguez, S. and Li, H. and Yen, K. and Ordoez, C.L. and Ahrens, R.

DOI: 10.1164/rccm.201301-0153OC

Embolization of a central venous catheter due to pinch-off syndrome

Acta Paediatrica, International Journal of Paediatrics

Gowraiah, V. and Culham, G. and Chilvers, M.A. and Yang, C.L.

DOI: 10.1111/apa.12085

Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses

Journal of Immunology

Blohmke, C.J. and Mayer, M.L. and Tang, A.C. and Hirschfeld, A.F. and Fjell, C.D. and Sze, M.A. and Falsafi, R. and Wang, S. and Hsu, K. and Chilvers, M.A. and Hogg, J.C. and Hancock, R.E.W. and Turvey, S.E.

DOI: 10.4049/jimmunol.1103661

Superior herniation of the mediastinum presenting as an anterior neck mass on straining

Pediatric Pulmonology

McDougall, C.M. and Culham, G. and Seear, M.D. and Chilvers, M.A.

DOI: 10.1002/ppul.21618

Inflammasome-mediated IL-1 production in humans with cystic fibrosis

PLoS ONE

Tang, A. and Sharma, A. and Jen, R. and Hirschfeld, A.F. and Chilvers, M.A. and Lavoie, P.M. and Turvey, S.E.

DOI: 10.1371/journal.pone.0037689

Cystic fibrosis adolescent transition care in Canada: A snapshot of current practice

Paediatrics and Child Health (Canada)

Gravelle, A. and Davidson, G. and Chilvers, M.

DOI: 10.1093/pch/17.10.553

Analysis of ependymal ciliary beat pattern and beat frequency using high speed imaging: Comparison with the photomultiplier and photodiode methods

Cilia

O'Callaghan, C. and Sikand, K. and Chilvers, M.A.

DOI: 10.1186/2046-2530-1-8

Effects of a Pseudomonas aeruginosa eradication policy in a cystic fibrosis clinic

Current Opinion in Pulmonary Medicine

Davidson, A.G.F. and Chilvers, M.A. and Lillquist, Y.P.

DOI: 10.1097/MCP.0b013e328358f5a2

Renal function in pediatric cystic fibrosis patients in the first decade of life

Pediatric Nephrology

Prestidge, C. and Chilvers, M.A. and Davidson, A.G.F. and Cho, E. and McMahon, V. and White, C.T.

DOI: 10.1007/s00467-010-1737-1

Case 1: Chronic cough in a Vietnamese adolescent: Should we be sweating?

Paediatrics and Child Health

Luu, K. and Chilvers, M.

DOI: 10.1093/pch/16.8.465a

Diagnostic testing of patients suspected of primary ciliary dyskinesia

American Journal of Respiratory and Critical Care Medicine

Stannard, W.A. and Chilvers, M.A. and Rutman, A.R. and Williams, C.D. and O'Callaghan, C.

DOI: 10.1164/rccm.200903-0459OC

TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis

Journal of Immunology

Blohmke, C.J. and Park, J. and Hirschfeld, A.F. and Victor, R.E. and Schneiderman, J. and Stefanowicz, D. and Chilvers, M.A. and Durie, P.R. and Corey, M. and Zielenski, J. and Dorfman, R. and Sandford, A.J. and Daley, D. and Turvey, S.E.

DOI: 10.4049/jimmunol.1001513

Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis

Immunology

Rzemieniak, S.E. and Hirschfeld, A.F. and Victor, R.E. and Chilvers, M.A. and Zheng, D. and Van Den Elzen, P. and Turvey, S.E.

DOI: 10.1111/j.1365-2567.2009.03234.x

Long-term comparative trial of two different physiotherapy techniques; postural drainage with percussion and autogenic drainage, in the treatment of cystic fibrosis

Pediatric Pulmonology

Mcilwaine, M. and Wong, L.T. and Chilvers, M. and Davidson, G.F.

DOI: 10.1002/ppul.21247

Pleuropulmonary complications of PVL-positive Staphylococcus aureus infection in children

Acta Paediatrica, International Journal of Paediatrics

Thomas, B. and Pugalenthi, A. and Chilvers, M.

DOI: 10.1111/j.1651-2227.2009.01293.x

Diagnosing primary ciliary dyskinesia

Thorax

O'Callaghan, C. and Chilvers, M. and Hogg, C. and Bush, A. and Lucas, J.

DOI: 10.1136/thx.2007.083147

Primary ciliary dyskinesia

Paediatrics and Child Health

Chilvers, M.A. and O'Callaghan, C.

DOI: 10.1016/j.paed.2007.02.003

Ciliary beat pattern is associated with specific ultrastructural defects in primary ciliary dyskinesia

Journal of Allergy and Clinical Immunology

Chilvers, M.A. and Rutman, A. and O'Callaghan, C.

DOI: 10.1016/S0091-6749(03)01799-8

Functional analysis of cilia and ciliated epithelial ultrastructure in healthy children and young adults

Thorax

Chilvers, M.A. and Rutman, A. and O'Callaghan, C.

DOI: 10.1136/thorax.58.4.333

The effects of coronavirus on human nasal ciliated respiratory epithelium

European Respiratory Journal

Chilvers, M.A. and McKean, M. and Rutman, A. and Myint, B.S. and Silverman, M. and O'Callaghan, C.

DOI: 10.1183/09031936.01.00093001

Case 1: Assessment: chronic wet cough.

Paediatric respiratory reviews

Chilvers, M.A. and O'Callaghan, C.

Analysis of ciliary beat pattern and beat frequency using digital high speed imaging: Comparison with the photomultiplier and photodiode methods

Thorax

Chilvers, M.A. and O'Callaghan, C.

DOI: 10.1136/thorax.55.4.314

Local mucociliary defence mechanisms

Paediatric Respiratory Reviews

Chilvers, M.A. and O'Callaghan, C.

DOI: 10.1053/prrv.2000.0009

Current Projects

Evalaution of a transitional pathway in CF care
This is a rewtrospective analysis of an quality improvement project to inpmprove health care in CF youth.

Current Projects

Adherence to therapy in CF patients
Co PI:
Self funded.
Evalaution of adherance therapy in CF patients. ldentifying bariers to adherance wuithin BC. This is a joint project with St Pauls.

Current Projects

Establishment of Digitial high speed video in the diagnosis of primary ciliary dyskinesia in BC.
Principal investigator for this trial
Funded: Telethon

Grants

Telethon Award 2009

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Mark Chilvers

MRCPCH, MD, BSc, MBChB

Investigator, BC Children's Hospital

Academic Affiliations

Contact Information

Location

Publications

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A Germline Heterozygous Dominant Negative IKZF2 Variant Causing Syndromic Primary Immune Regulatory Disorder and ICHAD

Vanzacaftor"tezacaftor"deutivacaftor versus elexacaftor"tezacaftor"ivacaftor in individuals with cystic fibrosis aged 12 years and older (SKYLINE Trials VX20-121-102 and VX20-121-103): results from two randomised, active-controlled, phase 3 trials

Elexacaftor/tezacaftor/ivacaftor in children aged =6 years with cystic fibrosis heterozygous for F508del and a minimal function mutation: results from a 96-week open-label extension study

Cost-Effectiveness of Infant and Maternal RSV Immunization Strategies

Standards for the care of people with cystic fibrosis; establishing and maintaining health

High-quality read-based phasing of cystic fibrosis cohort informs genetic understanding of disease modification

A Phase 3, open-label, 96-week trial to study the safety, tolerability, and efficacy of tezacaftor/ivacaftor in children = 6 years of age homozygous for F508del or heterozygous for F508del and a residual function CFTR variant

High Quality Phasing Using Linked-Read Whole Genome Sequencing of Patient Cohorts Informs Genetic Understanding of Complex Traits

Long-term respiratory outcomes following solid organ transplantation in children: A retrospective cohort study

Cystic fibrosis-related diabetes onset can be predicted using biomarkers measured at birth.

Long-term safety and efficacy of lumacaftor-ivacaftor therapy in children aged 6-11 years with cystic fibrosis homozygous for the F508del-CFTR mutation: a phase 3, open-label, extension study.

Outcomes of Cystic Fibrosis Screening"Positive Infants With Inconclusive Diagnosis at School Age

Genetic evidence supports the development of SLC26A9 targeting therapies for the treatment of lung disease

Long-term safety of lumacaftor"ivacaftor in children aged 2"5 years with cystic fibrosis homozygous for the F508del-CFTR mutation: a multicentre, phase 3, open-label, extension study

Correction to: Cystic fibrosis"related diabetes onset can be predicted using biomarkers measured at birth (Genetics in Medicine, (2021), 23, 5, (927-933), 10.1038/s41436-020-01073-x)

Role of transient elastography and apri in the assessment of pediatric cystic fibrosis liver disease

Nasal Brushing Sampling and Processing using Digital High Speed Ciliary Videomicroscopy - Adaptation for the COVID-19 Pandemic.

Factors influencing clinical trial participation for adult and pediatric patients with cystic fibrosis.

Matrix-assisted laser desorption/ionization time-of-flight MS for the accurate identification of Burkholderia cepacia complex and Burkholderia gladioli in the clinical microbiology laboratory

Performance of a three-tier (IRT-DNA-IRT) cystic fibrosis screening algorithm in British Columbia

Epidemiology of burkholderia infections in people with cystic fibrosis in Canada between 2000 and 2017

Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial

A phase 3 study of tezacaftor in combination with ivacaftor in children aged 6 through 11years with cystic fibrosis

An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2"5years (KLIMB)

Ciliary functional analysis: Beating a path towards standardization

Immunoreactive trypsinogen levels in newborn screened infants with an inconclusive diagnosis of cystic fibrosis

An investigation into biomarkers for the diagnosis of ABPA and aspergillus disease in cystic fibrosis

Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.

To beat, or not to beat, that is question! The spectrum of ciliopathies

Epidemiology of clonal pseudomonas aeruginosa infection in a canadian cystic fibrosis population

Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled phase 3 trial.

Response

Variation of Ciliary Beat Pattern in Three Different Beating Planes in Healthy Subjects

Adverse events following live-attenuated intranasal influenza vaccination of children with cystic fibrosis: Results from two influenza seasons

Viral interference and the live-attenuated intranasal influenza vaccine: Results from a pediatric cohort with cystic fibrosis

Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2-5 years with cystic fibrosis and a CFTR gating mutation (KIWI): an open-label, single-arm study.

Influenza virus detection following administration of live-attenuated intranasal influenza vaccine in children with cystic fibrosis and their healthy siblings

Dornase alfa for cystic fibrosis

Inconclusive Diagnosis of Cystic Fibrosis After Newborn Screening

Evaluation of a multidimensional cystic fibrosis transition program: A quality improvement initiative

Factors associated with response to treatment of pulmonary exacerbations in cystic fibrosis patients

Casting a look at pediatric plastic bronchitis

Burkholderia species infections in patients with cystic fibrosis in British Columbia, Canada: 30 years' experience

Randomized controlled trial of biofilm antimicrobial susceptibility testing in cystic fibrosis patients

Surgical masks reduce airborne spread of Pseudomonas aeruginosa in colonized patients with cystic fibrosis

Use of the SNOT-22 and UPSIT to appropriately select pediatric patients with cystic fibrosis who should be referred to an otolaryngologist: Cross-sectional study

In need of a patch UP: Recurrent congenital diaphragmatic hernia presenting with a large pleural effusion

Efficacy and safety of ivacaftor in patients aged 6 to 11 years with cystic fibrosis with a G551D mutation

Embolization of a central venous catheter due to pinch-off syndrome

Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses

Superior herniation of the mediastinum presenting as an anterior neck mass on straining

Inflammasome-mediated IL-1 production in humans with cystic fibrosis

Cystic fibrosis adolescent transition care in Canada: A snapshot of current practice

Analysis of ependymal ciliary beat pattern and beat frequency using high speed imaging: Comparison with the photomultiplier and photodiode methods

Effects of a Pseudomonas aeruginosa eradication policy in a cystic fibrosis clinic

Renal function in pediatric cystic fibrosis patients in the first decade of life

Case 1: Chronic cough in a Vietnamese adolescent: Should we be sweating?

Diagnostic testing of patients suspected of primary ciliary dyskinesia

TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis

Acidification-dependent activation of CD1d-restricted natural killer T cells is intact in cystic fibrosis

Long-term comparative trial of two different physiotherapy techniques; postural drainage with percussion and autogenic drainage, in the treatment of cystic fibrosis

Pleuropulmonary complications of PVL-positive Staphylococcus aureus infection in children

Diagnosing primary ciliary dyskinesia

Primary ciliary dyskinesia

Ciliary beat pattern is associated with specific ultrastructural defects in primary ciliary dyskinesia

Functional analysis of cilia and ciliated epithelial ultrastructure in healthy children and young adults

The effects of coronavirus on human nasal ciliated respiratory epithelium

Case 1: Assessment: chronic wet cough.

Analysis of ciliary beat pattern and beat frequency using digital high speed imaging: Comparison with the photomultiplier and photodiode methods

Local mucociliary defence mechanisms

Research