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Dan Goldowitz
PhD, BA

Investigator, BC Children's Hospital
Senior Scientist, Centre for Molecular Medicine and Therapeutics
Past Canada Research Chair, Tier 1

One of the most daunting problems of modern biology is to determine how a genome consisting of only ~30,000 genes drives the development of one of the most complex of organ systems – the mammalian brain. Most of the time – amazingly – the brain develops perfectly. When cells do not follow the proper developmental pathways, it leads to disorders of the developing central nervous system (CNS). These developmental brain disorders can have a clear genetic basis (e.g. certain Intellectual Disabilities and Huntington’s Disease) or a far more complex etiology that involves multiple genes and environmental factors (e.g. autism, attention deficit disorder [ADHD] and schizophrenia).

The lab studies both single gene and more complex developmental disorders of the CNS. The research integrates the power of genomics, informatics and the mouse as an experimental model system to drive discovery about normal and abnormal brain development and to identify new therapies and interventions to improve outcomes for affected children.

Academic Affiliations

  • Professor Emeritus/a, , Department of Medical Genetics, Faculty of Medicine, University of British Columbia
  • Research Theme: Brain, Behaviour & Development
  • Research Group(s): Mental Health and Behaviour; Neurodevelopmental and Neurological Disorders; Pain and Stress; Visualizing the Brain

Contact Information

Location

950 West 28th Avenue, Vancouver, BC, Canada, V5Z 4H4

(604) 875-3822

dang@cmmt.ubc.ca

A novel and multivalent role of pax6 in cerebellar development

Journal of Neuroscience

Yeung, J. and Ha, T.J. and Swanson, D.J. and Goldowitz, D.

DOI: 10.1523/JNEUROSCI.4385-15.2016

RAAV-compatible MiniPromoters for restricted expression in the brain and eye

Molecular Brain

De Leeuw, C.N. and Korecki, A.J. and Berry, G.E. and Hickmott, J.W. and Lam, S.L. and Lengyell, T.C. and Bonaguro, R.J. and Borretta, L.J. and Chopra, V. and Chou, A.Y. and D'Souza, C.A. and Kaspieva, O. and Laprise, S. and McInerny, S.C. and Portales-Casamar, E. and Swanson-Newman, M.I. and Wong, K. and Yang, G.S. and Zhou, M. and Jones, S.J.M. and Holt, R.A. and Asokan, A. and Goldowitz, D. and Wasserman, W.W. and Simpson, E.M.

DOI: 10.1186/s13041-016-0232-4

Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel

Psychopharmacology

Dickson, P.E. and Miller, M.M. and Calton, M.A. and Bubier, J.A. and Cook, M.N. and Goldowitz, D. and Chesler, E.J. and Mittleman, G.

DOI: 10.1007/s00213-015-4147-z

The cerebellum and SIDS: Disordered breathing in a mouse model of developmental cerebellar purkinje cell loss during recovery from hypercarbia

Frontiers in Neurology

Calton, M.A. and Howard, J.R. and Harper, R.M. and Goldowitz, D. and Mittleman, G.

DOI: 10.3389/fneur.2016.00078

Cerebellar contribution to higher and lower order rule learning and cognitive flexibility in mice

Neuroscience

Dickson, P.E. and Cairns, J. and Goldowitz, D. and Mittleman, G.

DOI: 10.1016/j.neuroscience.2016.03.040

CbGRiTS: Cerebellar gene regulation in time and space

Developmental Biology

Ha, T. and Swanson, D. and Larouche, M. and Glenn, R. and Weeden, D. and Zhang, P. and Hamre, K. and Langston, M. and Phillips, C. and Song, M. and Ouyang, Z. and Chesler, E. and Duvvurru, S. and Yordanova, R. and Cui, Y. and Campbell, K. and Ricker, G. and Phillips, C. and Homayouni, R. and Goldowitz, D.

DOI: 10.1016/j.ydbio.2014.09.032

Kruppel-like factor 4 regulates granule cell Pax6 expression and cell proliferation in early cerebellar development

PLoS ONE

Zhang, P. and Ha, T. and Larouche, M. and Swanson, D. and Goldowitz, D.

DOI: 10.1371/journal.pone.0134390

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

Science

Arner, E. and Daub, C.O. and Vitting-Seerup, K. and Andersson, R. and Lilje, B. and Drabl?s, F. and Lennartsson, A. and Rnnerblad, M. and Hrydziuszko, O. and Vitezic, M. and Freeman, T.C. and Alhendi, A.M.N. and Arner, P. and Axton, R. and Baillie, J.K. and Beckhouse, A. and Bodega, B. and Briggs, J. and Brombacher, F. and Davis, M. and Detmar, M. and Ehrlund, A. and Endoh, M. and Eslami, A. and Fagiolini, M. and Fairbairn, L. and Faulkner, G.J. and Ferrai, C. and Fisher, M.E. and Forrester, L. and Goldowitz, D. and Guler, R. and Ha, T. and Hara, M. and Herlyn, M. and Ikawa, T. and Kai, C. and Kawamoto, H. and Khachigian, L.M. and Klinken, S.P. and Kojima, S. and Koseki, H. and Klein, S. and Mejhert, N. and Miyaguchi, K. and Mizuno, Y. and Morimoto, M. and Morris, K.J. and Mummery, C. and Nakachi, Y. and Ogishima, S. and Okada-Hatakeyama, M. and Okazaki, Y. and Orlando, V. and Ovchinnikov, D. and Passier, R. and Patrikakis, M. and Pombo, A. and Qin, X.-Y. and Roy, S. and Sato, H. and Savvi, S. and Saxena, A. and Schwegmann, A. and Sugiyama, D. and Swoboda, R. and Tanaka, H. and Tomoiu, A. and Winteringham, L.N. and Wolvetang, E. and Yanagi-Mizuochi, C. and Yoneda, M. and Zabierowski, S. and Zhang, P. and Abugessaisa, I. and Bertin, N. and Diehl, A.D. and Fukuda, S. and Furuno, M. and Harshbarger, J. and Hasegawa, A. and Hori, F. and Ishikawa-Kato, S. and Ishizu, Y. and Itoh, M. and Kawashima, T. and Kojima, M. and Kondo, N. and Lizio, M. and Meehan, T.F. and Mungall, C.J. and Murata, M. and Nishiyori-Sueki, H. and Sahin, S. and Nagao-Sato, S. and Severin, J. and De Hoon, M.J.L. and Kawai, J. and Kasukawa, T. and Lassmann, T. and Suzuki, H. and Kawaji, H. and Summers, K.M. and Wells, C. and Hume, D.A. and Forrest, A.R.R. and Sandelin, A. and Carninci, P. and Hayashizaki, Y.

DOI: 10.1126/science.1259418

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

PLoS Biology

Hurst, L.D. and Ghanbarian, A.T. and Forrest, A.R.R. and Huminiecki, L. and Rehli, M. and Kenneth Baillie, J. and de Hoon, M.J.L. and Haberle, V. and Lassmann, T. and Kulakovskiy, I.V. and Lizio, M. and Itoh, M. and Andersson, R. and Mungall, C.J. and Meehan, T.F. and Schmeier, S. and Bertin, N. and J?rgensen, M. and Dimont, E. and Arner, E. and Schmidl, C. and Schaefer, U. and Medvedeva, Y.A. and Plessy, C. and Vitezic, M. and Severin, J. and Semple, C.A. and Ishizu, Y. and Young, R.S. and Francescatto, M. and Alam, I. and Albanese, D. and Altschuler, G.M. and Arakawa, T. and Archer, J.A.C. and Arner, P. and Babina, M. and Baker, S. and Balwierz, P.J. and Beckhouse, A.G. and Pradhan, S. and Blake, J.A. and Blumenthal, A. and Bodega, B. and Bonetti, A. and Briggs, J. and Brombacher, F. and Maxwell Burroughs, A. and Califano, A. and Cannistraci, C.V. and Carbajo, D. and Chen, Y. and Chierici, M. and Ciani, Y. and Clevers, H.C. and Dalla, E. and Davis, C.A. and Detmar, M. and Diehl, A.D. and Dohi, T. and Drabl?s, F. and Edge, A.S.B. and Edinger, M. and Ekwall, K. and Endoh, M. and Enomoto, H. and Fagiolini, M. and Fairbairn, L. and Fang, H. and Farach-Carson, M.C. and Faulkner, G.J. and Favorov, A.V. and Fisher, M.E. and Frith, M.C. and Fujita, R. and Fukuda, S. and Furlanello, C. and Furuno, M. and Furusawa, J.-I. and Geijtenbeek, T.B. and Gibson, A. and Gingeras, T. and Goldowitz, D. and Gough, J. and Guhl, S. and Guler, R. and Gustincich, S. and Ha, T.J. and Hamaguchi, M. and Hara, M. and Harbers, M. and Harshbarger, J. and Hasegawa, A. and Hasegawa, Y. and Hashimoto, T. and Herlyn, M. and Hitchens, K.J. and Ho Sui, S.J. and Hofmann, O.M. and Hoof, I. and Hori, F. and Huminiecki, L. and Iida, K. and Ikawa, T. and Jankovic, B.R. and Jia, H. and Joshi, A. and Jurman, G. and Kaczkowski, B. and Kai, C. and Kaida, K. and Kaiho, A. and Kajiyama, K. and Kanamori, M. and Kasianov, A.S. and Kasukawa, T. and Katayama, S. and Kato, S. and Kawaguchi, S. and Kawamoto, H. and Kawamura, Y.I. and Kawashima, T. and Kempfle, J.S. and Kenna, T.J. and Kere, J. and Khachigian, L.M. and Kitamura, T. and Peter Klinken, S. and Knox, A.J. and Kojima, M. and Kojima, S. and Kondo, N. and Koseki, H. and Koyasu, S. and Krampitz, S. and Kubosaki, A. and Kwon, A.T. and Laros, J.F.J. and Lee, W. and Lennartsson, A. and Li, K. and Lilje, B. and Lipovich, L. and Mackay, A. and Manabe, R. and Mar, J.C. and Marchand, B. and Mathelier, A. and Mejhert, N. and Meynert, A. and Mizuno, Y. and de Lima Morais, D.A. and Morikawa, H. and Morimoto, M. and Moro, K. and Motakis, E. and Motohashi, H. and Mummery, C.L. and Murata, M. and Nagao, S. and Nakachi, Y. and Nakahara, F. and Nakamura, T. and Nakamura, Y. and Nakazato, K. and van Nimwegen, E. and Ninomiya, N. and Nishiyori, H. and Noma, S. and Nozaki, T. and Ogishima, S. and Ohkura, N. and Ohmiya, H. and Ohno, H. and Ohshima, M. and Okada, M. and Okazaki, Y. and Orlando, V. and Ovchinnikov, D.A. and Pain, A. and Passier, R. and Patrikakis, M. and Persson, H. and Piazza, S. and Prendergast, J.G.D. and Rackham, O.J.L. and Ramilowski, J.A. and Rashid, M. and Ravasi, T. and Rizzu, P. and Roncador, M. and Roy, S. and Rye, M.B. and Saijyo, E. and Sajantila, A. and Saka, A. and Sakaguchi, S. and Sakai, M. and Sato, H. and Satoh, H. and Savvi, S. and Saxena, A. and Schneider, C. and Schultes, E.A. and Schulze-Tanzil, G.G. and Schwegmann, A. and Sengstag, T. and Sheng, G. and Shimoji, H. and Shimoni, Y. and Shin, J.W. and Simon, C. and Sugiyama, D. and Sugiyama, T. and Suzuki, M. and Suzuki, N. and Swoboda, R.K. and 't Hoen, P.A.C. and Tagami, M. and Takahashi, N. and Takai, J. and Tanaka, H. and Tatsukawa, H. and Tatum, Z. and Thompson, M. and Toyoda, H. and Toyoda, T. and Valen, E. and van de Wetering, M. and van den Berg, L.M. and Verardo, R. and Vijayan, D. and Vorontsov, I.E. and Wasserman, W.W. and Watanabe, S. and Wells, C.A. and Winteringham, L.N. and Wolvetang, E. and Wood, E.J. and Yamaguchi, Y. and Yamamoto, M. and Yoneda, M. and Yonekura, Y. and Yoshida, S. and Zabierowski, S.E. and Zhang, P.G. and Zhao, X. and Zucchelli, S. and Summers, K.M. and Suzuki, H. and Daub, C.O. and Kawai, J. and Heutink, P. and Hide, W. and Freeman, T.C. and Lenhard, B. and Bajic, V.B. and Taylor, M.S. and Makeev, V.J. and Sandelin, A. and Hume, D.A. and Carninci, P. and Hayashizaki, Y.

DOI: 10.1371/journal.pbio.1002315

Ethics challenges of transition from paediatric to adult health care services for young adults with neurodevelopmental disabilities

Paediatrics and Child Health (Canada)

Racine, E. and Bell, E. and Yan, A. and Andrew, G. and Bell, L.E. and Clarke, M. and Dubljevic, V. and Goldowitz, D. and Janvier, A. and McLachlan, K. and Muhajarine, N. and Nicholas, D. and Oskoui, M. and Rasmussen, C. and Anne Rasmussen, L. and Roberts, W. and Shevell, M. and Wade, L. and Yager, J.Y.

A promoter-level mammalian expression atlas

Nature

Forest, A.R.R. and Kawaji, H. and Rehli, M. and Baillie, J.K. and De Hoon, M.J.L. and Haberle, V. and Lassmann, T. and Kulakovskiy, I.V. and Lizio, M. and Itoh, M. and Andersson, R. and Mungall, C.J. and Meehan, T.F. and Schmeier, S. and Bertin, N. and J?rgensen, M. and Dimont, E. and Arner, E. and Schmidl, C. and Schaefer, U. and Medvedeva, Y.A. and Plessy, C. and Vitezic, M. and Severin, J. and Semple, C.A. and Ishizu, Y. and Young, R.S. and Francescatto, M. and Altschuler, I.A. and Albanese, D. and Altschule, G.M. and Arakawa, T. and Archer, J.A.C. and Arner, P. and Babina, M. and Rennie, S. and Balwierz, P.J. and Beckhouse, A.G. and Pradhan-Bhatt, S. and Blake, J.A. and Blumenthal, A. and Bodega, B. and Bonetti, A. and Briggs, J. and Brombacher, F. and Burroughs, A.M. and Califano, A. and Cannistraci, C.V. and Carbajo, D. and Chen, Y. and Chierici, M. and Ciani, Y. and Clevers, H.C. and Dalla, E. and Davis, C.A. and Detmar, M. and Diehl, A.D. and Dohi, T. and Drabl?s, F. and Edge, A.S.B. and Edinger, M. and Ekwall, K. and Endoh, M. and Enomoto, H. and Fagiolini, M. and Fairbairn, L. and Fang, H. and Farach-Carson, M.C. and Faulkner, G.J. and Favorov, A.V. and Fisher, M.E. and Frith, M.C. and Fujita, R. and Fukuda, S. and Furlanello, C. and Furuno, M. and Furusawa, J.-I. and Geijtenbeek, T.B. and Gibson, A.P. and Gingeras, T. and Goldowitz, D. and Gough, J. and Guhl, S. and Guler, R. and Gustincich, S. and Ha, T.J. and Hamaguchi, M. and Hara, M. and Harbers, M. and Harshbarger, J. and Hasegawa, A. and Hasegawa, Y. and Hashimoto, T. and Herlyn, M. and Hitchens, K.J. and Sui, S.J.H. and Hofmann, O.M. and Hoof, I. and Hori, F. and Huminiecki, L. and Iida, K. and Ikawa, T. and Jankovic, B.R. and Jia, H. and Joshi, A. and Jurman, G. and Kaczkowski, B. and Kai, C. and Kaida, K. and Kaiho, A. and Kajiyama, K. and Kanamori-Katayama, M. and Kasianov, A.S. and Kasukawa, T. and Katayama, S. and Kato, S. and Kawaguchi, S. and Kawamoto, H. and Kawamura, Y.I. and Kawashima, T. and Kempfle, J.S. and Kenna, T.J. and Kere, J. and Khachigian, L.M. and Kitamura, T. and Klinken, S.P. and Knox, A.J. and Kojima, M. and Kojima, S. and Kondo, N. and Koseki, H. and Koyasu, S. and Krampitz, S. and Kubosaki, A. and Kwon, A.T. and Laros, J.F.J. and Lee, W. and Lennartsson, A. and Li, K. and Lilje, B. and Lipovich, L. and Mackay-sim, A. and Manabe, R.-I. and Mar, J.C. and Marchand, B. and Mathelier, A. and Mejhert, N. and Meynert, A. and Mizuno, Y. and De Morais, D.A.L. and Morikawa, H. and Morimoto, M. and Moro, K. and Motakis, E. and Motohashi, H. and Mummery, C.L. and Murata, M. and Nagao-Sato, S. and Nakachi, Y. and Nakahara, F. and Nakamura, T. and Nakamura, Y. and Nakazato, K. and Van Nimwegen, E. and Ninomiya, N. and Nishiyori, H. and Noma, S. and Nozaki, T. and Ogishima, S. and Ohkura, N. and Ohmiya, H. and Ohno, H. and Ohshima, M. and Okada-Hatakeyama, M. and Okazaki, Y. and Orlando, V. and Ovchinnikov, D.A. and Pain, A. and Passier, R. and Patrikakis, M. and Persson, H. and Piazza, S. and Prendergast, J.G.D. and Rackham, O.J.L. and Ramilowski, J.A. and Rashid, M. and Ravasi, T. and Rizzu, P. and Roncador, M. and Roy, S. and Rye, M.B. and Saijyo, E. and Sajantila, A. and Saka, A. and Sakaguchi, S. and Sakai, M. and Sato, H. and Satoh, H. and Savvi, S. and Saxena, A. and Schneider, C. and Schultes, E.A. and Schulze-Tanzil, G.G. and Schwegmann, A. and Sengstag, T. and Sheng, G. and Shimoji, H. and Shimoni, Y. and Shin, J.W. and Simon, C. and Sugiyama, D. and Sugiyama, T. and Suzuki, M. and Suzuki, N. and Swoboda, R.K. and 'T Hoen, P.A.C. and Tagami, M. and Tagami, N.T. and Takai, J. and Tanaka, H. and Tatsukawa, H. and Tatum, Z. and Thompson, M. and Toyoda, H. and Toyoda, T. and Valen, E. and Van De Wetering, M. and Van Den Berg, L.M. and Verardo, R. and Vijayan, D. and Vorontsov, I.E. and Wasserman, W.W. and Watanabe, S. and Wells, C.A. and Winteringham, L.N. and Wolvetang, E. and Wood, E.J. and Yamaguchi, Y. and Yamamoto, M. and Yoneda, M. and Yonekura, Y. and Yoshida, S. and Zabierowski, S.E. and Zhang, P.G. and Zhao, X. and Zucchelli, S. and Summers, K.M. and Suzuki, H. and Daub, C.O. and Kawai, J. and Heutink, P. and Hide, W. and Freeman, T.C. and Lenhard, B. and Bajic, L.V.B. and Taylor, M.S. and Makeev, V.J. and Sandelin, A. and Hume, D.A. and Carninci, P. and Hayashizaki, Y.

DOI: 10.1038/nature13182

Molecular pathways underpinning ethanol-induced neurodegeneration

Frontiers in Genetics

Goldowitz, D. and Lussier, A.A. and Boyle, J.K. and Wong, K. and Lattimer, S.L. and Dubose, C. and Lu, L. and Kobor, M.S. and Hamre, K.M.

DOI: 10.3389/fgene.2014.00203

Wls provides a new compartmental view of the rhombic lip in mouse cerebellar development

Journal of Neuroscience

Yeung, J. and Ha, T.J. and Swanson, D.J. and Choi, K. and Goldowitz, D. and Tong, Y.

DOI: 10.1523/JNEUROSCI.1330-14.2014

Varied manifestations of persistent hyperplastic primary vitreous with graded somatic mosaic deletion of a single gene

Molecular Vision

Mary-Sinclair, M.N. and Wang, X. and Swanson, D.J. and Sung, C.Y. and Mendonca, E.A. and Wroblewski, K. and Baumer, S.H. and Goldowitz, D. and Jablonski, M.M. and Skapek, S.X.

The effect of hemorrhage on the development of the postnatal mouse cerebellum

Experimental Neurology

Yoo, J.Y.J. and Mak, G.K. and Goldowitz, D.

DOI: 10.1016/j.expneurol.2013.11.010

Identification of genetic loci that modulate cell proliferation in the adult rostral migratory stream using the expanded panel of BXD mice

BMC Genomics

Poon, A. and Goldowitz, D.

DOI: 10.1186/1471-2164-15-206

Glutamate dysfunction associated with developmental cerebellar damage: Relevance to autism spectrum disorders

Cerebellum

McKimm, E. and Corkill, B. and Goldowitz, D. and Albritton, L.M. and Homayouni, R. and Blaha, C.D. and Mittleman, G.

DOI: 10.1007/s12311-013-0541-4

CAGE-defined promoter regions of the genes implicated in Rett Syndrome

BMC Genomics

Vitezic, M. and Bertin, N. and Andersson, R. and Lipovich, L. and Kawaji, H. and Lassmann, T. and Sandelin, A. and Heutink, P. and Goldowitz, D. and Ha, T. and Zhang, P. and Patrizi, A. and Fagiolini, M. and Forrest, A.R.R. and Carninci, P. and Saxena, A.

DOI: 10.1186/1471-2164-15-1177

The effects of pre- and post-natal nicotine exposure and genetic background on the striatum and behavioral phenotypes in the mouse

Behavioural Brain Research

Balsevich, G. and Poon, A. and Goldowitz, D. and Wilking, J.A.

DOI: 10.1016/j.bbr.2014.02.038

Impaired Hypercarbic and Hypoxic Responses from Developmental Loss of Cerebellar Purkinje Neurons: Implications for Sudden Infant Death Syndrome

Cerebellum

Calton, M. and Dickson, P. and Harper, R.M. and Goldowitz, D. and Mittleman, G.

DOI: 10.1007/s12311-014-0592-1

Reorganization of circuits underlying cerebellar modulation of prefrontal cortical dopamine in mouse models of autism spectrum disorder

Cerebellum

Rogers, T.D. and Dickson, P.E. and McKimm, E. and Heck, D.H. and Goldowitz, D. and Blaha, C.D. and Mittleman, G.

DOI: 10.1007/s12311-013-0462-2

The expression of HDAC1 and HDAC2 during cerebellar cortical development

Cerebellum

Yoo, J.Y.J. and Larouche, M. and Goldowitz, D.

DOI: 10.1007/s12311-013-0459-x

Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice

BMC Biology

Schmouth, J.-F. and Castellarin, M. and Laprise, S. and Banks, K.G. and Bonaguro, R.J. and McInerny, S.C. and Borretta, L. and Amirabbasi, M. and Korecki, A.J. and Portales-Casamar, E. and Wilson, G. and Dreolini, L. and Jones, S.J.M. and Wasserman, W.W. and Goldowitz, D. and Holt, R.A. and Simpson, E.M.

DOI: 10.1186/1741-7007-11-106

Use of the Expanded Panel of BXD Mice Narrow QTL Regions in Ethanol-Induced Locomotor Activation and Motor Incoordination

Alcoholism: Clinical and Experimental Research

Dubose, C.S. and Chesler, E.J. and Goldowitz, D. and Hamre, K.M.

DOI: 10.1111/j.1530-0277.2012.01865.x

Is autism a disease of the cerebellum?: An integration of clinical and pre-clinical research

Frontiers in Systems Neuroscience

Rogers, T.D. and Mckimm, E. and Dickson, P.E. and Goldowitz, D. and Blaha, C.D. and Mittleman, G.

DOI: 10.3389/fnsys.2013.00015

Effects of stimulus salience on touchscreen serial reversal learning in a mouse model of fragile X syndrome

Behavioural Brain Research

Dickson, P.E. and Corkill, B. and McKimm, E. and Miller, M.M. and Calton, M.A. and Goldowitz, D. and Blaha, C.D. and Mittleman, G.

DOI: 10.1016/j.bbr.2013.05.060

Effects of age and strain on cell proliferation in the mouse rostral migratory stream

Neurobiology of Aging

Poon, A. and Goldowitz, D.

DOI: 10.1016/j.neurobiolaging.2012.12.021

Dab2IP GTPase Activating Protein Regulates Dendrite Development and Synapse Number in Cerebellum

PLoS ONE

Qiao, S. and Kim, S.-H. and Heck, D. and Goldowitz, D. and LeDoux, M.S. and Homayouni, R.

DOI: 10.1371/journal.pone.0053635

Excessive activation of tissue plasminogen activator makes a mouse nervous

Proceedings of the National Academy of Sciences of the United States of America

Goldowitz, D.

DOI: 10.1073/pnas.1309965110

Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum

European Journal of Neuroscience

Ha, T.J. and Swanson, D.J. and Kirova, R. and Yeung, J. and Choi, K. and Tong, Y. and Chesler, E.J. and Goldowitz, D.

DOI: 10.1111/j.1460-9568.2012.08221.x

Kainic acid-induced neuronal degeneration in hippocampal pyramidal neurons is driven by both intrinsic and extrinsic factors: Analysis of FVB/NC57BL/6 chimeras

Journal of Neuroscience

Liu, L. and Hamre, K.M. and Goldowitz, D.

DOI: 10.1523/JNEUROSCI.6478-11.2012

19p13.2 microduplication causes a Sotos syndrome-like phenotype and alters gene expression

Clinical Genetics

Lehman, A.M. and Du Souich, C. and Chai, D. and Eydoux, P. and Huang, J.L. and Fok, A.K. and Avila, L. and Swingland, J. and Delaney, A.D. and McGillivray, B. and Goldowitz, D. and Argiropoulos, B. and Kobor, M.S. and Boerkoel, C.F.

DOI: 10.1111/j.1399-0004.2010.01615.x

Gene Discovery: From Positional Cloning to Genomic Cloning

Gene Discovery for Disease Models

Gu, W. and Goldowitz, D.

DOI: 10.1002/9780470933947.ch1

Consensus paper: Pathological role of the cerebellum in Autism

Cerebellum

Fatemi, S.H. and Aldinger, K.A. and Ashwood, P. and Bauman, M.L. and Blaha, C.D. and Blatt, G.J. and Chauhan, A. and Chauhan, V. and Dager, S.R. and Dickson, P.E. and Estes, A.M. and Goldowitz, D. and Heck, D.H. and Kemper, T.L. and King, B.H. and Martin, L.A. and Millen, K.J. and Mittleman, G. and Mosconi, M.W. and Persico, A.M. and Sweeney, J.A. and Webb, S.J. and Welsh, J.P.

DOI: 10.1007/s12311-012-0355-9

Inter-disciplinary research in the pediatric neurosciences: the NeuroDevNet model. Introduction.

Seminars in pediatric neurology

Shevell, M. and Goldowitz, D.

The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice

Mammalian Genome

Di Curzio, D.L. and Goldowitz, D.

DOI: 10.1007/s00335-011-9315-9

Conserved and differential gene interactions in dynamical biological systems

Bioinformatics

Ouyang, Z. and Song, M. and Gth, R. and Ha, T.J. and Larouche, M. and Goldowitz, D.

DOI: 10.1093/bioinformatics/btr472

NeuroDevNet: A Canada Network of Centres of Excellence-To Realize a Vision by Effective Operations and Collaborative Mechanisms

Seminars in Pediatric Neurology

Lewis, N.J. and Goldowitz, D.

DOI: 10.1016/j.spen.2011.02.008

Introduction

Seminars in Pediatric Neurology

Shevell, M. and Goldowitz, D.

DOI: 10.1016/j.spen.2011.03.001

Fetal Alcohol Spectrum Disorders: Gene-Environment Interactions, Predictive Biomarkers, and the Relationship Between Structural Alterations in the Brain and Functional Outcomes

Seminars in Pediatric Neurology

Reynolds, J.N. and Weinberg, J. and Clarren, S. and Beaulieu, C. and Rasmussen, C. and Kobor, M. and Dube, M.-P. and Goldowitz, D.

DOI: 10.1016/j.spen.2011.02.006

Experimental Sey mouse chimeras reveal the developmental deficiencies of Pax6-null granule cells in the postnatal cerebellum

Developmental Biology

Swanson, D.J. and Goldowitz, D.

DOI: 10.1016/j.ydbio.2010.11.018

Dopamine dynamics associated with, and resulting from, schedule-induced alcohol self-administration: Analyses in dopamine transporter knockout mice

Alcohol

Mittleman, G. and Call, S.B. and Cockroft, J.L. and Goldowitz, D. and Matthews, D.B. and Blaha, C.D.

DOI: 10.1016/j.alcohol.2010.12.006

Linking Early Brain and Biological Development to Psychiatry

Journal of the Canadian Academy of Child and Adolescent Psychiatry

Goldowitz, D.

Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: A potential mechanism underlying the gateway effect of nicotine

Psychopharmacology

Dickson, P.E. and Rogers, T.D. and Lester, D.B. and Miller, M.M. and Matta, S.G. and Chesler, E.J. and Goldowitz, D. and Blaha, C.D. and Mittleman, G.

DOI: 10.1007/s00213-010-2159-2

The NeuroDevNet Vision

Seminars in Pediatric Neurology

Goldowitz, D. and McArthur, D.

DOI: 10.1016/j.spen.2011.02.007

Spatial and temporal requirements for huntingtin (Htt) in neuronal migration and survival during brain development

Journal of Neuroscience

Tong, Y. and Ha, T.J. and Liu, L. and Nishimoto, A. and Reiner, A. and Goldowitz, D.

DOI: 10.1523/JNEUROSCI.2774-11.2011

Connecting the dots of the cerebro-cerebellar role in cognitive function: Neuronal pathways for cerebellar modulation of dopamine release in the prefrontal cortex

Synapse

Rogers, T.D. and Dickson, P.E. and Heck, D.H. and Goldowitz, D. and Mittleman, G. and Blaha, C.D.

DOI: 10.1002/syn.20960

Inherited neuroaxonal dystrophy in dogs causing lethal, fetal-onset motor system dysfunction and cerebellar hypoplasia

The Journal of comparative neurology

Fyfe, J.C. and Al-Tamimi, R.A. and Castellani, R.J. and Rosenstein, D. and Goldowitz, D. and Henthorn, P.S.

DOI: 10.1002/cne.22423

High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains

Genes, Brain and Behavior

Philip, V.M. and Duvvuru, S. and Gomero, B. and Ansah, T.A. and Blaha, C.D. and Cook, M.N. and Hamre, K.M. and Lariviere, W.R. and Matthews, D.B. and Mittleman, G. and Goldowitz, D. and Chesler, E.J.

DOI: 10.1111/j.1601-183X.2009.00540.x

Repetitive behavior and increased activity in mice with Purkinje cell loss: A model for understanding the role of cerebellar pathology in autism

European Journal of Neuroscience

Martin, L.A. and Goldowitz, D. and Mittleman, G.

DOI: 10.1111/j.1460-9568.2009.07073.x

Behavioral flexibility in a mouse model of developmental cerebellar Purkinje cell loss

Neurobiology of Learning and Memory

Dickson, P.E. and Rogers, T.D. and Mar, N.D. and Martin, L.A. and Heck, D. and Blaha, C.D. and Goldowitz, D. and Mittleman, G.

DOI: 10.1016/j.nlm.2010.05.010

A regulatory toolbox of MiniPromoters to drive selective expression in the brain

Proceedings of the National Academy of Sciences of the United States of America

Portales-Casamar, E. and Swanson, D.J. and Liu, L. and De Leeuw, C.N. and Banks, K.G. and Ho Sui, S.J. and Fulton, D.L. and Ali, J. and Amirabbasi, M. and Arenillas, D.J. and Babyak, N. and Black, S.F. and Bonaguro, R.J. and Brauer, E. and Candido, T.R. and Castellarin, M. and Chen, J. and Chen, Y. and Cheng, J.C.Y. and Chopra, V. and Docking, T.R. and Dreolini, L. and D'Souza, C.A. and Flynn, E.K. and Glenn, R. and Hatakka, K. and Hearty, T.G. and Imanian, B. and Jiang, S. and Khorasan-zadeh, S. and Komljenovic, I. and Laprise, S. and Liao, N.Y. and Lim, J.S. and Lithwick, S. and Liu, F. and Liu, J. and Lu, M. and McConechy, M. and McLeod, A.J. and Milisavljevic, M. and Mis, J. and O'Connor, K. and Palma, B. and Palmquist, D.L. and Schmouth, J.-F. and Swanson, M.I. and Tam, B. and Ticoll, A. and Turner, J.L. and Varhol, R. and Vermeulen, J. and Watkins, R.F. and Wilson, G. and Wong, B.K.Y. and Wong, S.H. and Wong, T.Y.T. and Yang, G.S. and Ypsilanti, A.R. and Jones, S.J.M. and Holt, R.A. and Goldowitz, D. and Wasserman, W.W. and Simpson, E.M.

DOI: 10.1073/pnas.1009158107

Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha allele

European Journal of Neuroscience

Swanson, D.J. and Steshina, E.Y. and Wakenight, P. and Aldinger, K.A. and Goldowitz, D. and Millen, K.J. and Chizhikov, V.V.

DOI: 10.1111/j.1460-9568.2010.07330.x

Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects

Biochemical and Biophysical Research Communications

Samaan, G. and Yugo, D. and Rajagopalan, S. and Wall, J. and Donnell, R. and Goldowitz, D. and Gopalakrishnan, R. and Venkatachalam, S.

DOI: 10.1016/j.bbrc.2010.07.142

Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia

Progress in Neurobiology

Freedman, R. and Goldowitz, D.

DOI: 10.1016/j.pneurobio.2009.10.008

Identification of a Chr 11 quantitative trait locus that modulates proliferation in the rostral migratory stream of the adult mouse brain

European Journal of Neuroscience

Poon, A. and Li, Z. and Wolfe, G.W. and Lu, L. and Williams, R.W. and Hayes, N.L. and Nowakowski, R.S. and Goldowitz, D.

DOI: 10.1111/j.1460-9568.2010.07316.x

CAG repeat lengths = 335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse

Neurobiology of Disease

Dragatsis, I. and Goldowitz, D. and Del Mar, N. and Deng, Y.P. and Meade, C.A. and Liu, L. and Sun, Z. and Dietrich, P. and Yue, J. and Reiner, A.

DOI: 10.1016/j.nbd.2008.10.009

Standards for the publication of mouse mutant studies

Genes, Brain and Behavior

Crusio, W.E. and Goldowitz, D. and Holmes, A. and Wolfer, D.

DOI: 10.1111/j.1601-183X.2008.00438.x

Genetics of the hippocampal transcriptome in mouse: A systematic survey and online neurogenomics resource

Frontiers in Neuroscience

Overall, R.W. and Kempermann, G. and Peirce, J. and Lu, L. and Goldowitz, D. and Gage, F.H. and Goodwin, S. and Smit, A.B. and Airey, D.C. and Rosen, G.D. and Schalkwyk, L.C. and Sutter, T.R. and Nowakowski, R.S. and Whatley, S. and Williams, R.W.

DOI: 10.3389/neuro.15.003.2009

ENU induced single mutation locus on chr 16 leads to high-frequency hearing loss in mice

Genes and Genetic Systems

Jiao, Y. and Cai, C. and Kermany, M.H. and Yan, J. and Cai, Q. and Miller, D. and Goldowitz, D. and Li, X. and Yoo, T.-J. and Gu, W.

DOI: 10.1266/ggs.84.219

Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus

Genomics

Yang, G.S. and Banks, K.G. and Bonaguro, R.J. and Wilson, G. and Dreolini, L. and de Leeuw, C.N. and Liu, L. and Swanson, D.J. and Goldowitz, D. and Holt, R.A. and Simpson, E.M.

DOI: 10.1016/j.ygeno.2008.09.014

Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse

Alcohol

Mathews, T.A. and Brookshire, B.R. and Budygin, E.A. and Hamre, K. and Goldowitz, D. and Jones, S.R.

DOI: 10.1016/j.alcohol.2009.04.006

Acute mild footshock alters ethanol drinking and plasma corticosterone levels in C57BL/6J male mice, but not DBA/2J or A/J male mice

Alcohol

Matthews, D.B. and Morrow, A.L. and O'Buckley, T. and Flanigan, T.J. and Berry, R.B. and Cook, M.N. and Mittleman, G. and Goldowitz, D. and Tokunaga, S. and Silvers, J.M.

DOI: 10.1016/j.alcohol.2008.05.001

Cerebellar modulation of frontal cortex dopamine efflux in mice: Relevance to autism and schizophrenia

Synapse

Mittleman, G. and Goldowitz, D. and Heck, D.H. and Blaha, C.D.

DOI: 10.1002/syn.20525

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse

EMBO Journal

Jin, N. and Chow, C.Y. and Liu, L. and Zolov, S.N. and Bronson, R. and Davisson, M. and Petersen, J.L. and Zhang, Y. and Park, S. and Duex, J.E. and Goldowitz, D. and Meisler, M.H. and Weisman, L.S.

DOI: 10.1038/emboj.2008.248

Identification of a set of genes showing regionally enriched expression in the mouse brain

BMC Neuroscience

D'Souza, C.A. and Chopra, V. and Varhol, R. and Xie, Y.-Y. and Bohacec, S. and Zhao, Y. and Lee, L.L.C. and Bilenky, M. and Portales-Casamar, E. and He, A. and Wasserman, W.W. and Goldowitz, D. and Marra, M.A. and Holt, R.A. and Simpson, E.M. and Jones, S.J.M.

DOI: 10.1186/1471-2202-9-66

Genetic mapping of vocalization to a series of increasing acute footshocks using B6.A consomic and B6.D2 congenic mouse strains

Behavior Genetics

Matthews, D.B. and Chesler, E.J. and Cook, M.N. and Cockroft, J. and Philip, V.M. and Goldowitz, D.

DOI: 10.1007/s10519-008-9210-7

A mouse model of Waardenburg syndrome type IV resulting from an ENU-induced mutation in endothelin 3

Pigment Cell Research

Matera, I. and Cockroft, J.L. and Moran, J.L. and Beier, D.R. and Goldowitz, D. and Pavan, W.J.

DOI: 10.1111/j.1600-0749.2007.00371.x

Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the Arf tumor suppressor

Investigative Ophthalmology and Visual Science

Thornton, J.D. and Swanson, D.J. and Mary, M.N. and Pei, D. and Martin, A.C. and Pounds, S. and Goldowitz, D. and Skapek, S.X.

DOI: 10.1167/iovs.06-0765

The requirement of Pax6 for postnatal eye development: Evidence from experimental mouse chimeras

Investigative Ophthalmology and Visual Science

Li, S. and Goldowitz, D. and Swanson, D.J.

DOI: 10.1167/iovs.06-1482

PolymiRTS Database: Linking polymorphisms in microRNA target sites with complex traits

Nucleic Acids Research

Bao, L. and Zhou, M. and Wu, L. and Lu, L. and Goldowitz, D. and Williams, R.W. and Cui, Y.

DOI: 10.1093/nar/gkl797

An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes

Human Molecular Genetics

Bao, L. and Peirce, J.L. and Zhou, M. and Li, H. and Goldowitz, D. and Williams, R.W. and Lu, L. and Cui, Y.

DOI: 10.1093/hmg/ddm089

Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice

Developmental Biology

Du, X. and Jensen, P. and Goldowitz, D. and Hamre, K.M.

DOI: 10.1016/j.ydbio.2007.02.028

R6/2 neurons with intranuclear inclusions survive for prolonged periods in the brains of chimeric mice

Journal of Comparative Neurology

Reiner, A. and Del Mar, N. and Deng, Y.-P. and Meade, C.A. and Sun, Z. and Goldowitz, D.

DOI: 10.1002/cne.21515

Neurobehavioral mutants identified in an ENU-mutagenesis project

Mammalian Genome

Cook, M.N. and Dunning, J.P. and Wiley, R.G. and Chesler, E.J. and Johnson, D.K. and Miller, D.R. and Goldowitz, D.

DOI: 10.1007/s00335-007-9035-3

A transgenic mouse class-III tubulin reporter using yellow fluorescent protein

Genesis

Liu, L. and Geisert, E.E. and Frankfurter, A. and Spano, A.J. and Chloe, X.J. and Yue, J. and Dragatsis, I. and Goldowitz, D.

DOI: 10.1002/dvg.20325

Screening for ENU-Induced Mutations in Mice That Result in Aberrant Ethanol-Related Phenotypes

Behavioral Neuroscience

Hamre, K.M. and Goldowitz, D. and Wilkinson, S. and Matthews, D.B.

DOI: 10.1037/0735-7044.121.4.665

Huntingtin inhibits caspase-3 activation

EMBO Journal

Zhang, Y. and Leavitt, B.R. and Van Raamsdonk, J.M. and Dragatsis, I. and Goldowitz, D. and MacDonald, M.E. and Hayden, M.R. and Friedlander, R.M.

DOI: 10.1038/sj.emboj.7601445

Sustained attention in the mouse: A study of the relationship with the cerebellum

Behavioral Neuroscience

Martin, L.A. and Goldowitz, D. and Mittleman, G.

DOI: 10.1037/0735-7044.120.2.477

Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes

Alcoholism: Clinical and Experimental Research

Goldowitz, D. and Matthews, D.B. and Hamre, K.M. and Mittleman, G. and Chesler, E.J. and Becker, H.C. and Lopez, M.F. and Jones, S.R. and Mathews, T.A. and Miles, M.F. and Kerns, R. and Grant, K.A.

DOI: 10.1111/j.1530-0277.2006.00125.x

Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen

Hearing Research

Habiby Kermany, M. and Parker, L.L. and Guo, Y.-K. and Miller, D. and Swanson, D.J. and Yoo, T.-J. and Goldowitz, D. and Zuo, J.

DOI: 10.1016/j.heares.2006.07.011

Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships

Mammalian Genome

Bao, L. and Wei, L. and Peirce, J.L. and Homayouni, R. and Li, H. and Zhou, M. and Chen, H. and Lu, L. and Williams, R.W. and Pfeffer, L.M. and Goldowitz, D. and Cui, Y.

DOI: 10.1007/s00335-005-0172-2

The Tennessee Mouse Genome Consortium: Identification of ocular mutants

Visual Neuroscience

Jablonski, M.M. and Wang, X. and Lu, L. and Miller, D.R. and Rinchik, E.M. and Williams, R.W. and Goldowitz, D.

DOI: 10.1017/S0952523805225087

Increased calbindin-D28k immunoreactivity in striatal projection neurons of R6/2 Huntington's disease transgenic mice

Neurobiology of Disease

Sun, Z. and Wang, H.B. and Deng, Y.P. and Lei, W.L. and Xie, J.P. and Meade, C.A. and Del Mar, N. and Goldowitz, D. and Reiner, A.

DOI: 10.1016/j.nbd.2005.05.023

Compartmentation of the reeler cerebellum: Segregation and overlap of spinocerebellar and secondary vestibulocerebellar fibers and their target cells

Neuroscience

Vig, J. and Goldowitz, D. and Steindler, D.A. and Eisenman, L.M.

DOI: 10.1016/j.neuroscience.2004.09.051

An ENU-induced mutation in Rs1h causes disruption of retinal structure and function

Molecular Vision

Jablonski, M.M. and Dalke, C. and Wang, X.F. and Lu, L. and Manly, K.F. and Pretsch, W. and Favor, J. and Pardue, M.T. and Rinchik, E.M. and Williams, R.W. and Goldowitz, D. and Graw, J.

A deletion causing spontaneous fracture identified from a candidate region of mouse chromosome 14

Mammalian Genome

Jiao, Y. and Li, X. and Beamer, W.G. and Yan, J. and Tong, Y. and Goldowitz, D. and Roe, B. and Gu, W.

DOI: 10.1007/s00335-004-2414-0

Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice

Age

Johnson, D.K. and Rinchik, E.M. and Moustaid-Moussa, N. and Miller, D.R. and Williams, R.W. and Michaud, E.J. and Jablonski, M.M. and Elberger, A. and Hamre, K. and Smeyne, R. and Chesler, E. and Goldowitz, D.

DOI: 10.1007/s11357-005-4131-3

Disruption of cerebellar granule cell development in the Pax6 mutant, Sey mouse

Developmental Brain Research

Swanson, D.J. and Tong, Y. and Goldowitz, D.

DOI: 10.1016/j.devbrainres.2005.09.005

Enhanced Purkinje cell survival but compromised cerebellar function in targeted anti-apoptotic protein transgenic mice

Molecular and Cellular Neuroscience

Goswami, J. and Martin, L.A. and Goldowitz, D. and Beitz, A.J. and Feddersen, R.M.

DOI: 10.1016/j.mcn.2005.02.010

A genome end-game: Understanding gene function in the nervous system

Nature Neuroscience

Bult, C. and Kibbe, W.A. and Snoddy, J. and Vitaterna, M. and Swanson, D. and Pretel, S. and Li, Y. and Hohman, M.M. and Rinchik, E. and Takahashi, J.S. and Frankel, W.N. and Goldowitz, D.

DOI: 10.1038/nn0504-484

Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function

Molecular Brain Research

Goldowitz, D. and Frankel, W.N. and Takahashi, J.S. and Holtz-Vitaterna, M. and Bult, C. and Kibbe, W.A. and Snoddy, J. and Li, Y. and Pretel, S. and Yates, J. and Swanson, D.J.

DOI: 10.1016/j.molbrainres.2004.09.016

Analysis of Cerebellar Development in math1 Null Embryos and Chimeras

Journal of Neuroscience

Jensen, P. and Smeyne, R. and Goldowitz, D.

DOI: 10.1523/JNEUROSCI.3427-03.2004

A relationship between cerebellar Purkinje cells and spatial working memory demonstrated in a lurcher/chimera mouse model system

Genes, Brain and Behavior

Martin, L.A. and Escher, T. and Goldowitz, D. and Mittleman, G.

DOI: 10.1111/j.1601-183x.2004.00067.x

Implementing large-scale ENU mutagenesis screens in North America

Genetica

Clark, A.T. and Goldowitz, D. and Takahashi, J.S. and Vitaterna, M.H. and Siepka, S.M. and Peters, L.L. and Frankel, W.N. and Carlson, G.A. and Rossant, J. and Nadeau, J.H. and Justice, M.J.

DOI: 10.1007/s10709-004-1436-6

Wild-Type Huntingtin Plays a Role in Brain Development and Neuronal Survival

Molecular Neurobiology

Reiner, A. and Dragatsis, I. and Zeitlin, S. and Goldowitz, D.

DOI: 10.1385/MN:28:3:259

The cerebellum and spatial ability: Dissection of motor and cognitive components with a mouse model system

European Journal of Neuroscience

Martin, L.A. and Goldowitz, D. and Mittleman, G.

DOI: 10.1046/j.1460-9568.2003.02921.x

Plans for HDBase - A research community website for Huntington's disease

Clinical Neuroscience Research

Goodman, N. and McCormick, K. and Goldowitz, D. and Hockly, E. and Johnson, C. and Kristal, B. and MacDonald, M. and Truant, R. and van Beuzekom, M.

DOI: 10.1016/S1566-2772(03)00062-8

Dissection of the cellular and molecular events that position cerebellar Purkinje cells: A study of the math1 null-mutant mouse

Journal of Neuroscience

Jensen, P. and Zoghbi, H.Y. and Goldowitz, D.

The community effect and Purkinje cell migration in the cerebellar cortex: Analysis of scrambler chimeric mice

Journal of Neuroscience

Yang, H. and Jensen, P. and Goldowitz, D.

Clonal Architecture of the Mouse Hippocampus

Journal of Neuroscience

Martin, L.A. and Tan, S.-S. and Goldowitz, D.

Developmental expression of PAM (protein associated with MYC) in the rodent brain

Developmental Brain Research

Yang, H. and Scholich, K. and Poser, S. and Storm, D.R. and Patel, T.B. and Goldowitz, D.

DOI: 10.1016/S0165-3806(02)00311-5

The renal glomerulus and vasculature in 'Aggregation' chimeric mice

Nephron

Gattone II, V.H. and Goldowitz, D.

DOI: 10.1159/000049062

Cellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic mice

Journal of Comparative Neurology

Meade, C.A. and Deng, Y.-P. and Fusco, F.R. and Del Mar, N. and Hersch, S. and Goldowitz, D. and Reiner, A.

DOI: 10.1002/cne.10295

Preliminary analysis of the mouse cerebellum proteome

Molecular Brain Research

Beranova-Giorgianni, S. and Pabst, M.J. and Russell, T.M. and Giorgianni, F. and Goldowitz, D. and Desiderio, D.M.

DOI: 10.1016/S0169-328X(01)00333-3

Differential changes in striatal projection neurons in R6/2 transgenic mice for Huntington's disease

Neurobiology of Disease

Sun, Z. and Del Mar, N. and Meade, C. and Goldowitz, D. and Reiner, A.

DOI: 10.1006/nbdi.2002.0554

Abnormalities in the functioning of adipocytes from R6/2 mice that are transgenic for the Huntington's disease mutation

Human Molecular Genetics

Fain, J.N. and Del Mar, N.A. and Meade, C.A. and Reiner, A. and Goldowitz, D.

Sequence interpretation: Functional annotation of mouse genome sequences

Science

Nadeau, J.H. and Balling, R. and Barsh, G. and Beier, D. and Brown, S.D.M. and Bucan, M. and Camper, S. and Carlson, G. and Copeland, N. and Eppig, J. and Fletcher, C. and Frankel, W.N. and Ganten, D. and Goldowitz, D. and Goodnow, C. and Guenet, J.-L. and Hicks, G. and De Angelis, M.H. and Jackson, I. and Jacob, H.J. and Jenkins, N. and Johnson, D. and Justice, M. and Kay, S. and Kingsley, D. and Lehrach, H. and Magnuson, T. and Meisler, M. and Poustka, A. and Rinchik, E.M. and Rossant, J. and Russell, L.B. and Schimenti, J. and Shiroishi, T. and Skarnes, W.C. and Soriano, P. and Stanford, W. and Takahashi, J.S. and Wurst, W. and Zimmer, A.

DOI: 10.1126/science.1058244

Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice

Journal of Neuroscience

Reiner, A. and Del Mar, N. and Meade, C.A. and Yang, H. and Dragatsis, I. and Zeitlin, S. and Goldowitz, D.

Zona incerta: Substrate for contralateral interconnectivity in the thalamus of rats

Journal of Comparative Neurology

Beierbach, E. and Park, C. and Ackerman, S.L. and Goldowitz, D. and Hawkes, R.

DOI: 10.1002/cne.1053

Granule cells and cerebellar boundaries: Analysis of Unc5h3 mutant chimeras

Journal of Neuroscience

Goldowitz, D. and Hamre, K.M. and Przyborski, S.A. and Ackerman, S.L.

Extrinsic modulation of retinal ganglion cell projections: Analysis of the albino mutation in pigmentation mosaic mice

Developmental Biology

Rice, D.S. and Goldowitz, D. and Williams, R.W. and Hamre, K. and Johnson, P.T. and Tan, S.-S. and Reese, B.E.

DOI: 10.1006/dbio.1999.9467

Rescue of cerebellar granule cells from death in weaver NR1 double mutants

Journal of Neuroscience

Jensen, P. and Surmeier, D.J. and Goldowitz, D.

Disrupted retinal development in the embryonic belly spot and tail mutant mouse

Developmental Biology

Tang, Q. and Rice, D.S. and Goldowitz, D.

DOI: 10.1006/dbio.1998.9142

Drain development, VIII: the reeler mouse.

The American journal of psychiatry

Lombroso, P.J. and Goldowitz, D.

Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain

Development

Rice, D.S. and Sheldon, M. and D'Arcangelo, G. and Nakajima, K. and Goldowitz, D. and Curran, T.

The cells and molecules that make a cerebellum

Trends in Neurosciences

Goldowitz, D. and Hamre, K.

DOI: 10.1016/S0166-2236(98)01313-7

Novel receptor protein tyrosine phosphatase (RPTP) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex

Journal of Comparative Neurology

Mcandrew, P.E. and Frostholm, A. and Evans, J.E. and Zdilar, D. and Goldowitz, D. and Chiu, I.-M. and Burghes, A.H.M. and Rotter, A.

DOI: 10.1002/(SICI)1096-9861(19980222)391:4u0026lt;444::AID-CNE3u0026gt;3.0.CO;2-0

Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11

Journal of Neuroscience

Williams, R.W. and Strom, R.C. and Goldowitz, D.

Mapping genes that control brain size and neuron number: A QTL analysis of the mouse CNS and retina

FASEB Journal

Williams, R.W. and Strom, R.C. and Zhou, G. and Goldowitz, D. and Gilissen, E.P. and Rosen, G.D.

meander tail acts intrinsic to granule cell precursors to disrupt cerebellar development: Analysis of meander tail chimeric mice

Development

Hamre, K.M. and Goldowitz, D.

Scrambler and yotari disrupt the disabled gene and produce a reeler- like phenotype in mice

Nature

Sheldon, M. and Rice, D.S. and D'Arcangelo, G. and Yoneshima, H. and Nakajima, K. and Mikoshiba, K. and Howell, B.W. and Cooper, J.A. and Goldowitz, D. and Curran, T.

DOI: 10.1038/39601

Cerebellar mutant mice and chimeras revisited

Perspectives on Developmental Neurobiology

Mullen, R.J. and Hamre, K.M. and Goldowitz, D.

Birthdate and cell marker analysis of scrambler: A novel mutation affecting cortical development with a reeler-like phenotype

Journal of Neuroscience

Gonzlez, J.L. and Russo, C.J. and Goldowitz, D. and Sweet, H.O. and Davisson, M.T. and Walsh, C.A.

Developmental expression of the GIRK family of inward rectifying potassium channels: Implications for abnormalities in the weaver mutant mouse

Brain Research

Chen, S.-C. and Ehrhard, P. and Goldowitz, D. and Smeyne, R.J.

DOI: 10.1016/S0006-8993(97)00896-2

Decreased retinal ganglion cell number and misdirected axon growth associated with fissure defects in Bst/+ mutant mice

Investigative Ophthalmology and Visual Science

Rice, D.S. and Tang, Q. and Williams, R.W. and Harris, B.S. and Davisson, M.T. and Goldowitz, D.

Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelin

Journal of Neuroscience

Goldowitz, D. and Gushing, R.C. and Laywell, E. and D'Arcangelo, G. and Sheldon, M. and Sweet, H.O. and Davisson, M. and Steindler, D. and Curran, T.

Genetic and environmental control of variation in retinal ganglion cell number in mice

Journal of Neuroscience

Williams, R.W. and Strom, R.C. and Rice, D.S. and Goldowitz, D.

The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells

Proceedings of the National Academy of Sciences of the United States of America

Surmeier, D.J. and Mermelstein, P.G. and Goldowitz, D.

DOI: 10.1073/pnas.93.20.11191

Analysis of gene action in the meander tail mutant mouse: Examination of cerebellar phenotype and mitotic activity of granule cell neuroblasts

Journal of Comparative Neurology

Hamre, K.M. and Goldowitz, D.

DOI: 10.1002/(SICI)1096-9861(19960429)368:2u0026lt;304::AID-CNE10u0026gt;3.0.CO;2-H

Annexin IV is a marker of roof and floor plate development in the murine CNS

Journal of Comparative Neurology

Hamre, K.M. and Keller-Peck, C.R. and Campbell, R.M. and Peterson, A.C. and Mullen, R.J. and Goldowitz, D.

DOI: 10.1002/(SICI)1096-9861(19960513)368:4u0026lt;527::AID-CNE5u0026gt;3.0.CO;2-6

Clonal architecture of the mouse retina

Progress in Brain Research

Goldowitz, D. and Rice, D.S. and Williams, R.W.

Arbitrary primer PCR of dog DNA with estimates of average heterozygosity

Journal of Heredity

Ezer, A.D. and Williams, R.W. and Goldowitz, D.

Developmental regulation of various annexins in the embryonic palate of the mouse: Dexamethasone affects expression of annexin-1

Journal of Craniofacial Genetics and Developmental Biology

Chepenik, K.P. and Shipman-Appasamy, P. and Ahn, N. and Goldowitz, D.

Tune into the weaver channel

Nature Genetics

Goldowitz, D. and Smeyne, R.J.

DOI: 10.1038/ng1095-107

The annexins: Specific markers of midline structures and sensory neurons in the developing murine central nervous system

Journal of Comparative Neurology

Hamre, K.M. and Chepenik, K.P. and Goldowitz, D.

DOI: 10.1002/cne.903520308

Mapping the Bst mutation on mouse Chromosome 16: a model for human optic atrophy

Mammalian Genome

Rice, D.S. and Williams, R.W. and Ward-Bailey, P. and Johnson, K.R. and Harris, B.S. and Davisson, M.T. and Goldowitz, D.

DOI: 10.1007/BF00356174

Genetic control of retinal projections in inbred strains of albino mice

Journal of Comparative Neurology

Rice, D.S. and Williams, R.W. and Goldowitz, D.

DOI: 10.1002/cne.903540312

Inhibition of migration of neural crest-derived cells by the abnormal mesenchyme of the presumptive aganglionic bowel of Is/Is mice: Analysis with aggregation and interspecies chimeras

Developmental Biology

Rothman, T.P. and Goldowitz, D. and Gershon, M.D.

Reply

Trends in Neurosciences

Williams, R.W. and Goldowitz, D.

DOI: 10.1016/0166-2236(93)90132-6

Lineage versus environment in embryonic retina: a revisionist perspective

Trends in Neurosciences

Williams, R.W. and Goldowitz, D.

DOI: 10.1016/0166-2236(92)90181-7

Distribution of the blood-brain barrier in heterotopic brain transplants and its relationship to the lesions of EAE

Journal of Neuropathology and Experimental Neurology

Knobler, R.L. and Marini, J.C. and Goldowitz, D. and Lublin, F.D.

Structure of clonal and polyclonal cell arrays in chimeric mouse retina

Proceedings of the National Academy of Sciences of the United States of America

Williams, R.W. and Goldowitz, D.

Abnormalities in premigratory granule cells in the weaver cerebellum defined by monoclonal antibody OZ42

Anatomy and Embryology

Smeyne, R.J. and Pickford, L.B. and Rouse, R.V. and Napieralski, J. and Goldowitz, D.

DOI: 10.1007/BF00192209

Expression of prostaglandin G H synthase (cyclooxygenase) during murine fetal thymic development

Cellular Immunology

Appasamy, P.M. and Pendino, K. and Schmidt, R.R. and Chepenik, K.P. and Prystowsky, M.B. and Goldowitz, D.

DOI: 10.1016/0008-8749(91)90084-O

Purkinje cell loss is due to a direct action of the weaver gene in Purkinje cells: evidence from chimeric mice

Developmental Brain Research

Smeyne, R.J. and Goldowitz, D.

DOI: 10.1016/0165-3806(90)90237-S

Olivocerebellar fiber maturation in normal and lurcher mutant mice: Defective development in lurcher

Journal of Comparative Neurology

Heckroth, J.A. and Goldowitz, D. and Eisenman, L.M.

DOI: 10.1002/cne.902910308

NCAM gene expression during the development of cerebellum and dentate gyrus in the mouse

Developmental Brain Research

Goldowitz, D. and Barthels, D. and Lorenzon, N. and Jungblut, A. and Wille, W.

DOI: 10.1016/0165-3806(90)90230-V

Postnatal development of the wild-type and weaver cerebellum after embryonic administration of propylthiouracil (PTU)

Developmental Brain Research

Smeyne, R.J. and Goldowitz, D.

DOI: 10.1016/0165-3806(90)90151-N

Development and death of external granular layer cells in the weaver mouse cerebellum: A quantitative study

Journal of Neuroscience

Smeyne, R.J. and Goldowitz, D.

Purkinje cell reduction in the reeler mutant mouse: A quantitative immunohistochemical study

Journal of Comparative Neurology

Heckroth, J.A. and Goldowitz, D. and Eisenman, L.M.

The weaver granuloprival phenotype is due to intrinsic action of the mutant locus in granule cells: Evidence from homozygous weaver chimeras

Neuron

Goldowitz, D.

DOI: 10.1016/0896-6273(89)90045-7

Cell allocation in mammalian CNS formation: Evidence from murine interspecies aggregation chimeras

Neuron

Goldowitz, D.

DOI: 10.1016/0896-6273(89)90239-0

The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21

Genomics

Reeves, R.H. and Crowley, M.R. and Lorenzon, N. and Pavan, W.J. and Smeyne, R.J. and Goldowitz, D.

DOI: 10.1016/0888-7543(89)90018-9

Description of Putative ribosomal RNAs with low abundance, developmental regulation, and the identifier sequence

Experimental Cell Research

Herget, T. and Goldowitz, D. and Oelemann, W. and Starzinski-Powitz, A.

DOI: 10.1016/0014-4827(88)90128-0

Brain transplantation in genetic analysis of experimental allergic encephalomyelitis

Annals of the New York Academy of Sciences

Lublin, F.D. and Knobler, R.L. and Marini, J. and Goldowitz, D.

Evidence for the transneuronal regulation of cerebellin biosynthesis in developing Purkinje cells

Journal of Neuroscience

Slemmon, J.R. and Goldowitz, D. and Blacher, R. and Morgan, J.I.

Heterotopic brain transplants in the study of experimental allergic encephalomyelitis

Experimental Neurology

Goldowitz, D. and Knobler, R.L. and Lublin, F.D.

DOI: 10.1016/0014-4886(87)90122-1

Cell partitioning and mixing in the formation of the CNS: analysis of the cortical somatosensory barrels in chimeric mice.

Brain Research

Goldowitz, D.

Brain Transplantation in the Study of Host Regulation of Susceptibility to Experimental Allergic Encephalomyelitis

Annals of the New York Academy of Sciences

GOLDOWITZ, D. and LUBLIN, F.D. and KNOBLER, R.L.

DOI: 10.1111/j.1749-6632.1987.tb23717.x

A highly abundant transcript in adult murine cerebellar granule cells contains repetitive sequences homologous to L1.

Journal of Neuroscience

Schaal, H. and Goldowitz, D. and Heinlein, U.A. and Unterbeck, A. and Ruppert, C. and Papenbrock, T. and Mller-Hill, B. and Vielmetter, W. and Wille, W.

Cell partitioning and mixing in the formation of the CNS: analysis of the cortical somatosensory barrels in chimeric mice

Developmental Brain Research

Goldowitz, D.

DOI: 10.1016/0165-3806(87)90002-2

Performance of normal and neurological mutant mice on radial arm maze and active avoidance tasks

Behavioral and Neural Biology

Goldowitz, D. and Koch, J.

DOI: 10.1016/S0163-1047(86)90696-5

Proto-oncogene c-myc is expressed in cerebellar neurons at different developmental stages.

The EMBO journal

Ruppert, C. and Goldowitz, D. and Wille, W.

Longitudinal assessment of immunologic abnormalities of mice with the autosomal recessive mutation, 'wasted'

Journal of Immunology

Goldowitz, D. and Shipman, P.M. and Porter, J.F. and Schmidt, R.R.

Longitudinal assessment of immunological abnormalities of mice with the autosomal recessive mutation, wasted

Federation Proceedings

Shipman, P. and Goldowitz, D. and Porter, J. and Schmidt, R.

Degree of hyperinnervation of area dentata by locus coeruleus in the presence of septum or entorhinal cortex as studied by sequential intraocular triple transplantation

Experimental Brain Research

Goldowitz, D. and Seiger, ?. and Olson, L.

DOI: 10.1007/BF00236291

Regulation of axonal ingrowth into area dentata as studied by sequential, double intraocular brain tissue transplantation

Journal of Comparative Neurology

Goldowitz, D. and Seiger, A. and Olson, L.

The neurological mutation staggerer is expressed in embryonic cerebellar transplants matured in the anterior eye chamber of normal mice

Neuroscience Letters

Wille, W. and Goldowitz, D. and Seiger, A. and Olson, L.

DOI: 10.1016/0304-3940(83)90412-3

Immunohistochemical demonstration of plasticity in GABA neurons of the adult rat dentate gyrus

Brain Research

Goldowitz, D. and Vincent, S.R. and Wu, J.-Y. and Hkfelt, T.

DOI: 10.1016/0006-8993(82)90116-0

Anatomy of the isolated area dentata grown in the rat anterior eye chamber

Journal of Comparative Neurology

Goldowitz, D. and Seiger, A. and Olson, L.

Granule cell as a site of gene action in the weaver mouse cerebellum: Evidence from heterozygous mutant chimeras

Journal of Neuroscience

Goldowitz, D. and Mullen, R.J.

Nuclear morphology of ichthyosis mutant mice as a cell marker in chimeric brain

Developmental Biology

Goldowitz, D. and Mullen, R.J.

DOI: 10.1016/0012-1606(82)90313-X

Differential adrenergic neurotoxicity and Timm staining of heavy metals after intraocular injections of lead, cadmium or mercury

General Pharmacology: Vascular System

Bjorklund, H. and Goldowitz, D. and Hoffer, B. and Olson, L.

Axonal transport and axon sprouting in the adult rat dentate gyrus: An autoradiographic study

Neuroscience

Goldowitz, D. and Cotman, C.W.

DOI: 10.1016/0306-4522(80)90133-5

Do neurotrophic interactions control synapse formation in the adult rat brain?

Brain Research

Goldowitz, D. and Cotman, C.W.

DOI: 10.1016/0006-8993(80)90616-2

The specificity of reactive synaptogenesis: A comparative study in the adult rat hippocampal formation

Brain Research

Goldowitz, D. and Scheff, S.W. and Cotman, C.W.

DOI: 10.1016/0006-8993(79)90962-4

Induction of extensive fimbrial branching in the adult rat brain [18]

Nature

Goldowitz, D. and Cotman, C.W.

DOI: 10.1038/275064a0

Electrophysiological analysis of the projection from the contralateral entorhinal cortex to the dentate gyrus in normal rats

Brain Research

Frost White, W. and Goldowitz, D. and Lynch, G. and Cotman, C.W.

DOI: 10.1016/0006-8993(76)90666-1

Anatomical evidence for a projection from the entorhinal cortex to the contralateral dentate gyrus of the rat

Experimental Neurology

Goldowitz, D. and White, W.F. and Steward, O. and Lynch, G. and Cotman, C.

DOI: 10.1016/0014-4886(75)90075-8

Decreased temporal variability in hippocampal theta rhythms of cats administered methylphenidate

Behavioral Biology

Halfon, N. and Goldowitz, D. and Glotzbach, S. and Berger, R.

DOI: 10.1016/S0091-6773(75)91129-3

Gene-environment interactions in cerebellar development and function: insights into the origins of complex brain disorders

Fetal and perinatal events such as growth restriction and extreme prematurity exert a system-wide effect and falls under the framework of the developmental origins of health and disease. Our work will identify key transcriptomic and epigenomic changes that will suggest targets for intervention. We have used this approach with intraventricular hemorrhage (IVH) and our initial work with intra-uterine growth restriction (IUGR). For example, with IUGR we saw that the cerebellar epigenome had alterations in methylation. Treatment of the IUGR mice with a methyl-donor rich diet ameliorated the cerebellar phenotype and function of the IUGR pups, as well as altered the epigenome.

Mouse models for understanding neurodevelopmental disorders and interventions

We have 4 projects at various stages of development that were designed to examine neurodevelopmental disorders: the loss of Purkinje cells in autism (one of the few documented neuroanatomic hallmarks of autism), a sequelae of extreme prematurity, intraventricular haemorrhage (IVH), and a mouse model for intrauterine growth restriction (IUGR) which is associated with adverse outcomes in humans; and a mouse model for brain insults coupled with inflammatory challenges that are risk factors in prematurity.

Novel genes involved in cerebellar development: discovery & validation

We use two large databases that we have built (www.cbgrits.org) or contributed to (fantom.gsc.riken.jp) that have painted a relatively complete transcriptome landscape of the cerebellum over developmental time and discover new genes and their relationship to other genes and gene pathways. We will validate the role of these genes in cerebellar development using techniques such as siRNA knockdown, genetically engineered knockouts and experimental chimeras. In addition we have built two datasets relative to the role of non-coding elements of the genome (enhancers and microRNAs) in the development of the cerebellum.

Current Projects

My focus is on the cerebellum, a brain region involved in numerous levels of basic and higher function, and associated with developmental and behavioural disorders (eg, autism, ADHD, schizophrenia, developomental coordination disorder). Our lab’s strength is in approaching neurodevelopment through the lens of genetics to (i) discover and validate genes involved in cerebellar development; (ii) create mouse models of perturbed cerebellar function to identify the earliest diagnostic signs of the disorder and develop evidence-based interventions; and (iii) understand the role of complex genetics, such as gene-environment interactions, in cerebellar development. One current project is focusing on the key role of a region of the developing cerebellum, the rhombic lip, in the etiology and ontogeny of one of the most common tumours of the pediatric brain, the medulloblastoma. Here, as with the general approach in the lab, the work at the bench is meant to be translated to possible treatments in humans.

Honours & Awards

Co-PI CHILD-BRIGHT SPOR Research Network, 2017-present

Canadian Research Chair in Developmental Neurogenetics Tier 1, 2007 - 2021

Scientific Director, NeuroDevNet NCE, 2009 – current

University of Florida, Applebaum Professorship, 2009

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