- Overview
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My current research is focused on Clostridioides difficile infection. C. difficile is a common bacterium in the human gut that usually does not cause infection but in certain circumstances can cause diarrhea. It is significant because it can easily spread from patient to patient in hospitals if infection prevention measures and environmental cleaning practices are suboptimal. The current focus is on the interpretation of indeterminate (antigen positive/toxin negative) C. difficile testing and how patients are managed. I'm also aiming to improve the diagnostic stewardship of C. difficile to ensure that testing is done when clinically indicated and the right sample is collected.
- Publications
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Extraction-free clinical detection of SARS-CoV-2 virus from saline gargle samples using Hamilton STARlet liquid handler
Scientific Reports
Gadkar, V.J. and Goldfarb, D.M. and Al-Rawahi, G.N. and Srigley, J.A. and Smailus, D.E. and Coope, R.J.N. and Pleasance, S. and Watson, N. and Chen, T. and Lam, S. and Hoang, L. and Tilley, P.A.G.
DOI: 10.1038/s41598-023-30993-2
2023Trends in Clostridioides difficile infection rates in Canadian hospitals during the coronavirus disease 2019 (COVID-19) pandemic
Infection Control and Hospital Epidemiology
Choi, K.B. and Du, T. and Silva, A. and Golding, G.R. and Pelude, L. and Mitchell, R. and Rudnick, W. and Hizon, R. and Al-Rawahi, G.N. and Chow, B. and Davis, I. and Evans, G.A. and Frenette, C. and Johnstone, J. and Kibsey, P. and Katz, K.C. and Langley, J.M. and Lee, B.E. and Longtin, Y. and Mertz, D. and Minion, J. and Science, M. and Srigley, J.A. and Stagg, P. and Suh, K.N. and Thampi, N. and Wong, A. and Comeau, J.L. and Hota, S.S.
DOI: 10.1017/ice.2022.210
2023Epidemiology and associated risk factors for candidemia in a Canadian tertiary paediatric hospital: An 11-year review
JAMMI
Liu, S.H. and Mitchell, H. and Al-Rawahi, G.N.
DOI: 10.3138/jammi-2022-0021
2023Limitation of ctrA as a Target for Neisseria meningitidis Identification and Potential Alternative Targets
Journal of Clinical Microbiology
Sirluck-Schroeder, I. and Al-Rawahi, G.N. and Gadkar, V. and Hoang, L. and Tsang, R. and Tilley, P.
DOI: 10.1128/jcm.00152-22
2022Evaluation of observed and unobserved self-collection of saline gargle samples for the detection of SARS-CoV-2 in outpatients
Diagnostic Microbiology and Infectious Disease
Kinshella, M.-L.W. and Tilley, P. and Al-Rawahi, G.N. and Srigley, J.A. and Kayda, I. and Canes, M. and McLennan, M. and Bone, J.N. and Dittrick, M. and Gadkar, V.J. and Hoang, L.M.N. and Goldfarb, D.M.
DOI: 10.1016/j.diagmicrobio.2021.115566
2022COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
International Journal of Infectious Diseases
Leung, W.F. and Chorlton, S. and Tyson, J. and Al-Rawahi, G.N. and Jassem, A.N. and Prystajecky, N. and Masud, S. and Deans, G.D. and Chapman, M.G. and Mirzanejad, Y. and Murray, M.C.M. and Wong, P.H.P.
DOI: 10.1016/j.ijid.2021.10.045
2022Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015-2019
Emerging Infectious Diseases
Du, T. and Choi, K.B. and Silva, A. and Golding, G.R. and Pelude, L. and Hizon, R. and Al-Rawahi, G.N. and Brooks, J. and Chow, B. and Collet, J.C. and Comeau, J.L. and Davis, I. and Evans, G.A. and Frenette, C. and Han, G. and Johnstone, J. and Kibsey, P. and Katz, K.C. and Langley, J.M. and Lee, B.E. and Longtin, Y. and Mertz, D. and Minion, J. and Science, M. and Srigley, J.A. and Stagg, P. and Suh, K.N. and Thampi, N. and Wong, A. and Hota, S.S.
DOI: 10.3201/eid2806.212262
2022Characterization of Extensively Drug-Resistant (XDR) Carbapenemase-Producing Enterobacterales (CPE) in Canada from 2019 to 2020
Microbiology Spectrum
Bartoszko, J.J. and Mitchell, R. and Katz, K. and Mulvey, M. and Mataseje, L. and Al-Rawahi, G.N. and Davis, I. and Ellis, C. and Embree, J. and Hota, S.S. and Kibsey, P. and Leis, J.A. and McGeer, A. and Minion, J. and Musto, S. and Rajda, E. and Smith, S.W. and Srigley, J.A. and Suh, K.N. and Thampi, N. and Tomlinson, J. and Wong, T. and Pelude, L. and Rudnick, W. and Choi, K.B. and Silva, A. and Steele, V. and Cayen, J. and McClellan, C.
DOI: 10.1128/spectrum.00975-22
2022Self-Collected Saline Gargle Samples as an Alternative to Health Care Worker-Collected Nasopharyngeal Swabs for COVID-19 Diagnosis in Outpatients
Journal of Clinical Microbiology
David M. Goldfarb and Peter Tilley and Ghada N. Al-Rawahi and Jocelyn A. Srigley and Geoffrey Ford and Heather Pedersen and Abhilasha Pabbi and Stephanie Hannam-Clark and Marthe Charles and Michelle Dittrick and Vijay J. Gadkar and Jeffrey M. Pernica and Linda M. N. Hoang
DOI: 10.1128/JCM.02427-20
03/2021Septic arthritis due to Mycoplasma orale in a young patient with hypogammaglobulinemia
JAMMI
Liu, A.C. and Harvey, M. and Lee, A. and Hildebrand, K. and Hoang, L. and Gantt, S. and Al-Rawahi, G.N.
DOI: 10.3138/JAMMI-2021-0002
2021Development and validation of a new triplex real-time quantitative reverse Transcriptase-PCR assay for the clinical detection of SARS-CoV-2
Molecular and Cellular Probes
Gadkar, V.J. and Goldfarb, D.M. and Young, V. and Watson, N. and Al-Rawahi, G.N. and Srigley, J. and Tilley, P.
DOI: 10.1016/j.mcp.2021.101744
2021Self-collected Saline Gargle Samples as an Alternative to Healthcare Worker Collected Nasopharyngeal Swabs for COVID-19 Diagnosis in Outpatients
David M. Goldfarb and Peter Tilley and Ghada N. Al-Rawahi and Jocelyn A. Srigley and Geoffrey Ford and Heather Pedersen and Abhilasha Pabbi and Stephanie Hannam-Clark and Marthe Charles and Michelle Dittrick and Vijay J. Gadkar and Jeffrey M. Pernica and Linda M. N. Hoang
DOI: 10.1101/2020.09.13.20188334
09/2020Prevalence of Candida auris in Canadian acute care hospitals among at-risk patients, 2018
Antimicrobial Resistance and Infection Control
Garcia-Jeldes, H.F. and Mitchell, R. and McGeer, A. and Rudnick, W. and Amaratunga, K. and Vallabhaneni, S. and Lockhart, S.R. and Al-Rawahi, G. and Brodkin, E. and Charles, M. and Comeau, J. and Davis, I. and Delport, J. and Dingle, T.C. and Dufresne, P. and Ellis, C. and Embree, J. and Frenette, C. and Golding, G. and Hoang, L.M. and Hota, S. and Katz, K.C. and Kibsey, P. and Kus, J.V. and Langley, J.M. and Lee, B.E. and Lefebvre, M.-A. and Longtin, Y. and Malejczyk, K. and Masud, S. and Mertz, D. and Mulvey, M.R. and Poutanen, S. and Purych, D. and Rantelidis, R. and Richardson, D. and Schwartz, I.S. and Smith, S. and Tremblay, M.-A. and Wong, T. and Yamamura, D. and Bharat, A.
DOI: 10.1186/s13756-020-00752-3
2020Gargle-Direct: Extraction-free detection of SARS-CoV-2 using real-time PCR (RT-qPCR) of saline gargle rinse samples
medRxiv
Gadkar, V.J. and Goldfarb, D.M. and Young, V. and Watson, N. and Hoang, L. and Lee, T. and Prystajecky, N. and Al-Rawahi, G.N. and Srigley, J.A. and Tilley, P.
DOI: 10.1101/2020.10.09.20203430
2020Contribution of Real-Time Xpert MTB/RIF Testing to Establishing Early Diagnosis of Pediatric Extrapulmonary Tuberculosis in a Nonendemic Setting: A Case Series
Pediatric Infectious Disease Journal
Mijovi?, H. and Al-Nasser, Y. and Al-Rawahi, G.N. and Roberts, A.D.
DOI: 10.1097/INF.0000000000002488
2020Performance of the BD Phoenix Automated Microbiology System for Trimethoprim-Sulfamethoxazole Susceptibility Testing of Staphylococcus aureus
Journal of Clinical Microbiology
Ghada N. Al-Rawahi and Sam Chorlton and Sukhvinder Dhaliwal and George R. Golding and Peter Tilley
DOI: 10.1128/JCM.00994-19
12/2019Pediatric oncology and stem cell transplant patients with healthcare-associated Clostridium difficile infection were already colonized on admission
Pediatric Blood & Cancer
Ghada N. Al-Rawahi and Abeer Al-Najjar and Rachel McDonald and Rebecca J. Deyell and George R. Golding and Rollin Brant and Peter Tilley and Eva Thomas and Shahrad R. Rassekh and Aisling O'Gorman and Peggy Wong and Lucy Turnham and Simon Dobson
DOI: 10.1002/pbc.27604
05/2019Prevalence and clinical impact of methicillin-resistant Staphylococcus aureus colonization among infants at a level III neonatal intensive care unit
American Journal of Infection Control
Lavie-Nevo, K. and Srigley, J.A. and Al-Rawahi, G.N. and Bone, J. and Osiovich, H. and Roberts, A. and Ting, J.Y.
DOI: 10.1016/j.ajic.2019.04.173
2019Running out of options: Extensively drug-resistant urinary tract infection in an infant
Paediatrics and Child Health (Canada)
Mijovic, H. and Wakeham, S. and Ng, K. and Al-Rawahi, G.N. and Tilley, P. and Ho, L. and Roberts, A.
DOI: 10.1093/pch/pxz048
2019Baylisascariasis: A young boy with neural larva migrans due to the emerging raccoon round worm
Annals of Clinical and Translational Neurology
Dunbar, M. and Lu, S. and Chin, B. and Huh, L. and Dobson, S. and Al-Rawahi, G.N. and Morshed, M.G. and Vanden Driessche, K.
DOI: 10.1002/acn3.694
2019Asymptomatic Pharyngeal Carriage of Kingella kingae among Young Children in Vancouver, British Columbia, Canada
Pediatric Infectious Disease Journal
Masud, S. and Greenman, J. and Mulpuri, K. and Hasan, M.R. and Goldfarb, D.M. and Tilley, P. and Gadkar, V.J. and Al-Rawahi, G.N.
DOI: 10.1097/INF.0000000000002403
2019Measles Lymphadenopathy in a Child With PFAPA Syndrome
Pediatric and Developmental Pathology
Terry, J. and Brown, K. and Hiebert, J. and Al-Rawahi, G.N. and Moxham, J.P. and Krajden, M. and Jassem, A.N. and Tucker, L.
DOI: 10.1177/1093526617727970
2018Ten-year-old traveller with fever and an exceptional exanthem
Journal of Paediatrics and Child Health
Osowicki, J. and Badawi, M. and Al-Rawahi, G.N. and Rehmus, W.E. and Sauvé, L.
DOI: 10.1111/jpc.1_13703
2018Comparative evaluation of laboratory developed real-time PCR assays and RealStar(®) BKV PCR Kit for quantitative detection of BK polyomavirus.
Hasan MR and Tan R and Al-Rawahi G and Thomas E and Tilley P
DOI: 10.1016/j.jviromet.2016.04.009
PubMed: 27091098
08/2016Evaluation of amplification targets for the specific detection of Bordetella pertussis using real-time polymerase chain reaction.
Hasan MR and Tan R and Al-Rawahi GN and Thomas E and Tilley P
PubMed: 25285127
07/2014Granulomatous herpes simplex encephalitis in an infant with multicystic encephalopathy: a distinct clinicopathologic entity?
Schutz PW and Fauth CT and Al-Rawahi GN and Pugash D and White VA and Stockler S and Dunham CP
DOI: 10.1016/j.pediatrneurol.2013.12.008
PubMed: 24485930
04/2014Carriage of methicillin-resistant Staphylococcus aureus by wild urban Norway rats (Rattus norvegicus).
Himsworth CG and Miller RR and Montoya V and Hoang L and Romney MG and Al-Rawahi GN and Kerr T and Jardine CM and Patrick DM and Tang P and Weese JS
DOI: 10.1371/journal.pone.0087983
PubMed: 24498421
2014AMMI Canada – CACMID Annual Conference: April 2–5, 2014, Victoria, British Columbia.
2014Evaluation of amplification targets for the specific detection of Bordetella pertussis using real-time polymerase chain reaction
Canadian Journal of Infectious Diseases and Medical Microbiology
Hasan, M.R. and Tan, R. and Al-Rawahi, G.N. and Thomas, E. and Tilley, P.
DOI: 10.1155/2014/763128
2014Clostridium difficile vertebral osteomyelitis.
Al-Najjar A and Al-Rawahi GN and Hoang LM and Kollmann TR
DOI: 10.1097/inf.0b013e318296b424
PubMed: 23594589
09/2013Optimal use of MRSASelect and PCR to maximize sensitivity and specificity of MRSA detection.
Hasan MR and Brunstein JD and Al-Rawahi G and Tan R and Thomas E and Tilley P
DOI: 10.1007/s00284-012-0241-1
PubMed: 23053488
01/2013Ten-year review of candidemia in a Canadian tertiary care centre: Predominance of non-albicans Candida species
Canadian Journal of Infectious Diseases and Medical Microbiology
Al-Rawahi, G.N. and Roscoe, D.L.
DOI: 10.1155/2013/929717
2013Ten-year review of candidemia in a Canadian tertiary care centre: Predominance of non-albicans Candida species.
Al-Rawahi GN and Roscoe DL
PubMed: 24421833
2013Short-term stability of pathogen-specific nucleic acid targets in clinical samples.
Hasan MR and Tan R and Al-Rawahi GN and Thomas E and Tilley P
DOI: 10.1128/jcm.02659-12
PubMed: 23052319
12/2012Severe genital ulceration in an acute epstein-barr virus infection.
Al-Rawahi GN and Dobson SR and Scheifele DW and Rassekh SR and Murphy JJ
DOI: 10.1097/inf.0b013e3181f41b2e
PubMed: 20736877
02/2011Swift mobilization of infection control, employee health, clinicians, engineering, laboratory and public health averted secondary cases following a large measles exposure at the British Columbia Children’s Hospital, Vancouver, BC, Canada.
Thomas E and Dobson S and Al-Rawahi G and Holmes L and Gustafson R and Papilla S and Hoang L and Tilley P
2011Community-associated CMRSA-10 (USA-300) is the predominant strain among methicillin-resistant Staphylococcus aureus strains causing skin and soft tissue infections in patients presenting to the emergency department of a Canadian tertiary care hospital.
Al-Rawahi GN and Reynolds S and Porter SD and Forrester L and Kishi L and Chong T and Bowie WR and Doyle PW
DOI: 10.1016/j.jemermed.2007.09.030
PubMed: 18325716
01/2010Anaerobic brain abscess following chronic suppurative otitis media in a child from Uganda.
Cox K and Al-Rawahi G and Kollmann T
PubMed: 20808460
2009Anaerobic brain abscess following chronic suppurative otitis media in a child from Uganda
Canadian Journal of Infectious Diseases and Medical Microbiology
Cox, K.A. and Al-Rawahi, G. and Kollmann, T.R.
DOI: 10.1155/2009/407139
2009Case report: failure of subcutaneous ivermectin in treating Strongyloides hyperinfection.
Leung V and Al-Rawahi GN and Grant J and Fleckenstein L and Bowie W
PubMed: 19052292
12/2008First report of isolation and characterization of Aurantimonas altamirensis from clinical samples.
Luong ML and Békal S and Vinh DC and Lauzon D and Leung V and Al-Rawahi GN and Ng B and Burdz T and Bernard K
DOI: 10.1128/jcm.00337-08
PubMed: 18495852
07/2008HIV-1 viral load after leukodepletion.
Al-Muharrmi Z and Al-Jabri AA and Al-Rawahi G and Scrimgeor EM and Al-Marhobi A
DOI: 10.1097/qai.0b013e318160a694
PubMed: 18520683
06/2008Methicillin-resistant Staphylococcus aureus nasal carriage among injection drug users: six years later.
Al-Rawahi GN and Schreader AG and Porter SD and Roscoe DL and Gustafson R and Bryce EA
DOI: 10.1128/jcm.01596-07
PubMed: 18039800
02/2008AMMI Canada?CACMID 2008 Annual Conference February 27 ? March 2, 2008 Sheraton Vancouver Wall Centre Hotel, Vancouver, British Columbia.
01/2008Case report: Failure of subcutaneous ivermectin in treating Strongyloides hyperinfection
American Journal of Tropical Medicine and Hygiene
Leung, V. and Al-Rawahi, G.N. and Grant, J. and Fleckenstein, L. and Bowie, W.
DOI: 10.4269/ajtmh.2008.79.853
2008 - Research
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Candidemia
To determine the epidemiology of candidemia in adults and children and the incidence of mixed candidemia.
To describe the correlation of antifungal susceptibility results with clinical outcome.Clostridium difficile in pediatric oncology
To determine the prevalence of indeterminate C. difficile results and correlate with the clinical management and outcome.
To establish a diagnostic stewardship QI focusing on C. difficile testing as a start.Catheter-associated UTI (CAUTI)
To implement insertion and maintenance bundles for urinary catheters.
To create an electronic tool to collect consistent and accurate CAUTI information.
To reduce the rate of CAUTI.Research Group MembersMichelle Dittrick, Clinical Research Program Manager
Research Roundup: January 2022
This month’s Research Roundup covers how increasing parent-child proximity in the first days of life can improve toddler behaviour later on, what lean body mass can tell us about the health of pediatric kidney transplant recipients, insights into the barriers to knowledge translation in Canadian pediatric health-care centres, and an evaluation of the effectiveness of saline gargle COVID-19 tests.
