BCCHR Researchers Find a Researcher

Jeffrey Davis

MD, BEng

Investigator Emeritus, BC Children's Hospital

As site Principle Investigator for the Centre for International Bone Marrow Transplant Research (CIBMTR) group, my interests are focused on co-operative, inter-disciplinary programmes aimed at tackling the varied challenges presented by pediatric oncology and hematology patients.

My background in engineering and current experience as a U.S. Naval Flight Surgeon underlines my interest in human factor analysis and risk management within the practice of medicine. In an effort to reduce risk in health management to its lowest possible level, the naval aviation community's use of the "best practice" process to effectively identify, analyze and eliminate or help control a hazard can successfully be applied to our daily endeavors in medicine and will provide insight and options to our practices.

Academic Affiliations

Clinical Associate Professor Emeritus/a, Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, University of British Columbia
Research Theme: Childhood Diseases
Research Group(s): Childhood Cancer and Blood Research

The Adverse Event Landscape of Stem Cell Transplant: Evidence for AGVHD Driving Early Transplant Associated Toxicities

Transplantation and Cellular Therapy

Takahashi, T. and Watkins, B. and Bratrude, B. and Neuberg, D. and Hebert, K. and Betz, K. and Yu, A. and Choi, S.W. and Davis, J. and Duncan, C. and Giller, R. and Grimley, M. and Harris, A.C. and Jacobsohn, D. and Lalefar, N. and Farhadfar, N. and Pulsipher, M.A. and Shenoy, S. and Petrovic, A. and Schultz, K.R. and Yanik, G.A. and Blazar, B.R. and Horan, J.T. and Langston, A. and Kean, L.S. and Qayed, M.

DOI: 10.1016/j.jtct.2024.03.030

Overlap chronic GVHD is associated with adverse survival outcomes compared to classic chronic GVHD

Bone Marrow Transplantation

Gorfinkel, L. and Raghunandan, S. and Watkins, B. and Hebert, K. and Neuberg, D.S. and Bratrude, B. and Betz, K. and Yu, A. and Choi, S.W. and Davis, J. and Duncan, C. and Giller, R. and Grimley, M. and Harris, A.C. and Jacobsohn, D. and Lalefar, N. and Farhadfar, N. and Pulsipher, M.A. and Shenoy, S. and Petrovic, A. and Schultz, K.R. and Yanik, G.A. and Blazar, B.R. and Horan, J.T. and Langston, A. and Kean, L.S. and Qayed, M.

DOI: 10.1038/s41409-024-02245-y

Prospective PTCTC trial of myeloablative haplo-BMT with posttransplant cyclophosphamide for pediatric acute leukemias

Blood Advances

Fierro-Pineda, J.C. and Tsai, H.-L. and Blackford, A. and Cluster, A. and Caywood, E. and Dalal, J. and Davis, J. and Egeler, M. and Huo, J. and Hudspeth, M. and Keating, A. and Kelly, S.S. and Krueger, J. and Lee, D. and Lehmann, L. and Madden, L. and Oshrine, B. and Pulsipher, M.A. and Fry, T. and Symons, H.J.

DOI: 10.1182/bloodadvances.2023010281

Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events

Blood

Takahashi, T. and Al-Kofahi, M. and Jaber, M. and Bratrude, B. and Betz, K. and Suessmuth, Y. and Yu, A. and Neuberg, D.S. and Choi, S.W. and Davis, J. and Duncan, C. and Giller, R. and Grimley, M. and Harris, A.C. and Jacobsohn, D. and Lalefar, N. and Farhadfar, N. and Pulsipher, M.A. and Shenoy, S. and Petrovic, A. and Schultz, K.R. and Yanik, G.A. and Blazar, B.R. and Horan, J.T. and Watkins, B. and Langston, A. and Qayed, M. and Kean, L.S.

DOI: 10.1182/blood.2023020035

Abatacept for GVHD prophylaxis can reduce racial disparities by abrogating the impact of mismatching in unrelated donor stem cell transplantation

Blood Advances

Qayed, M. and Watkins, B. and Gillespie, S. and Bratrude, B. and Betz, K. and Choi, S.W. and Davis, J. and Duncan, C. and Giller, R. and Grimley, M. and Harris, A.C. and Jacobsohn, D. and Lalefar, N. and Norkin, M. and Farhadfar, N. and Pulsipher, M.A. and Shenoy, S. and Petrovic, A. and Schultz, K.R. and Yanik, G.A. and Waller, E.K. and Langston, A. and Kean, L.S. and Horan, J.T.

DOI: 10.1182/bloodadvances.2021005208

Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD

Journal of Clinical Oncology

Watkins, B. and Qayed, M. and McCracken, C. and Bratrude, B. and Betz, K. and Suessmuth, Y. and Yu, A. and Sinclair, S. and Furlan, S. and Bosinger, S. and Tkachev, V. and Rhodes, J. and Tumlin, A.G. and Narayan, A. and Cribbin, K. and Gillespie, S. and Gooley, T.A. and Pasquini, M.C. and Hebert, K. and Kapoor, U. and Rogatko, A. and Tighiouart, M. and Kim, S. and Bresee, C. and Choi, S.W. and Davis, J. and Duncan, C. and Giller, R. and Grimley, M. and Harris, A.C. and Jacobsohn, D. and Lalefar, N. and Norkin, M. and Farhadfar, N. and Pulsipher, M.A. and Shenoy, S. and Petrovic, A. and Schultz, K.R. and Yanik, G.A. and Waller, E.K. and Levine, J.E. and Ferrara, J.L. and Blazar, B.R. and Langston, A. and Horan, J.T. and Kean, L.S.

DOI: 10.1200/JCO.20.01086

Ifosfamide, gemcitabine, and vinorelbine is an effective salvage regimen with excellent stem cell mobilization in relapsed or refractory pediatric Hodgkin lymphoma

Pediatric Blood and Cancer

Marr, K. and Ronsley, R. and Nadel, H. and Douglas, K. and Gershony, S. and Strahlendorf, C. and Davis, J.H. and Deyell, R.J.

DOI: 10.1002/pbc.28167

PTPRD copy number variants and Ewing's sarcoma: Strengthening the association and therapeutic implications

Cancer Genetics

Saskin, A. and Seath, K. and Tihy, F. and Lemyre, E. and Davis, J. and Halal, F. and Armstrong, L.

DOI: 10.1016/j.cancergen.2019.03.004

Immune Reconstitution and Infection Patterns after Early Alemtuzumab and Reduced Intensity Transplantation for Nonmalignant Disorders in Pediatric Patients

Biology of Blood and Marrow Transplantation

Bhatt, S.T. and Bednarski, J.J. and Berg, J. and Trinkaus, K. and Murray, L. and Hayashi, R. and Schulz, G. and Hente, M. and Grimley, M. and Chan, K.W. and Kamani, N. and Jacobsohn, D. and Nieder, M. and Hale, G. and Yu, L. and Adams, R. and Dalal, J. and Pulsipher, M.A. and Haut, P. and Chaudhury, S. and Davis, J. and Jaroscak, J. and Andreansky, M. and Willert, J. and Shenoy, S.

DOI: 10.1016/j.bbmt.2018.10.008

Outcomes of Measurable Residual Disease in Pediatric Acute Myeloid Leukemia before and after Hematopoietic Stem Cell Transplant: Validation of Difference from Normal Flow Cytometry with Chimerism Studies and Wilms Tumor 1 Gene Expression

Biology of Blood and Marrow Transplantation

Jacobsohn, D.A. and Loken, M.R. and Fei, M. and Adams, A. and Brodersen, L.E. and Logan, B.R. and Ahn, K.W. and Shaw, B.E. and Kletzel, M. and Olszewski, M. and Khan, S. and Meshinchi, S. and Keating, A. and Harris, A. and Teira, P. and Duerst, R.E. and Margossian, S.P. and Martin, P.L. and Petrovic, A. and Dvorak, C.C. and Nemecek, E.R. and Boyer, M.W. and Chen, A.R. and Davis, J.H. and Shenoy, S. and Savasan, S. and Hudspeth, M.P. and Adams, R.H. and Lewis, V.A. and Kheradpour, A. and Kasow, K.A. and Gillio, A.P. and Haight, A.E. and Bhatia, M. and Bambach, B.J. and Haines, H.L. and Quigg, T.C. and Greiner, R.J. and Talano, J.-A.M. and Delgado, D.C. and Cheerva, A. and Gowda, M. and Ahuja, S. and Ozkaynak, M. and Mitchell, D. and Schultz, K.R. and Fry, T.J. and Loeb, D.M. and Pulsipher, M.A.

DOI: 10.1016/j.bbmt.2018.06.010

Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes

JCI insight

Wong, J.C. and Bryant, V. and Lamprecht, T. and Ma, J. and Walsh, M. and Schwartz, J. and Del Pilar Alzamora, M. and Mullighan, C.G. and Loh, M.L. and Ribeiro, R. and Downing, J.R. and Carroll, W.L. and Davis, J. and Gold, S. and Rogers, P.C. and Israels, S. and Yanofsky, R. and Shannon, K. and Klco, J.M.

DOI: 10.1172/jci.insight.121086

SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery

Blood

Haddad, E. and Logan, B.R. and Griffith, L.M. and Buckley, R.H. and Parrott, R.E. and Prockop, S.E. and Small, T.N. and Chaisson, J. and Dvorak, C.C. and Murnane, M. and Kapoor, N. and Abdel-Azim, H. and Hanson, I.C. and Martinez, C. and Bleesing, J.J.H. and Chandra, S. and Smith, A.R. and Cavanaugh, M.E. and Jyonouchi, S. and Sullivan, K.E. and Burroughs, L. and Skoda-Smith, S. and Haight, A.E. and Tumlin, A.G. and Quigg, T.C. and Taylor, C. and Dvila Saldaa, B.J. and Keller, M.D. and Seroogy, C.M. and Desantes, K.B. and Petrovic, A. and Leiding, J.W. and Shyr, D.C. and Decaluwe, H. and Teira, P. and Gillio, A.P. and Knutsen, A.P. and Moore, T.B. and Kletzel, M. and Craddock, J.A. and Aquino, V. and Davis, J.H. and Yu, L.C. and Cuvelier, G.D.E. and Bednarski, J.J. and Goldman, F.D. and Kang, E.M. and Shereck, E. and Porteus, M.H. and Connelly, J.A. and Fleisher, T.A. and Malech, H.L. and Shearer, W.T. and Szabolcs, P. and Thakar, M.S. and Vander Lugt, M.T. and Heimall, J. and Yin, Z. and Pulsipher, M.A. and Pai, S.-Y. and Kohn, D.B. and Puck, J.M. and Cowan, M.J. and O?Reilly, R.J. and Notarangelo, L.D.

DOI: 10.1182/blood-2018-03-840702

Health-Related Quality of Life in Survivors of High-Risk Neuroblastoma After Stem Cell Transplant: A National Population-Based Perspective

Pediatric Blood and Cancer

Portwine, C. and Rae, C. and Davis, J. and Teira, P. and Schechter, T. and Lewis, V. and Mitchell, D. and Wall, D.A. and Pullenayegum, E. and Barr, R.D.

DOI: 10.1002/pbc.26063

Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation

Clinical Immunology

Rozmus, J. and McDonald, R. and Fung, S.-Y. and Del Bel, K.L. and Roden, J. and Senger, C. and Schultz, K.R. and McKinnon, M.L. and Davis, J. and Turvey, S.E.

DOI: 10.1016/j.clim.2016.04.011

Hematopoietic Cell Transplantation Using Reduced-Intensity Conditioning Is Successful in Children with Hematologic Cytopenias of Genetic Origin

Biology of Blood and Marrow Transplantation

Kothari, A. and Ngwube, A. and Hayashi, R. and Murray, L. and Davis, J. and Haut, P. and Loechelt, B.J. and Shenoy, S.

DOI: 10.1016/j.bbmt.2015.03.019

Haematopoietic stem cell transplantation for refractory Langerhans cell histiocytosis: Outcome by intensity of conditioning

British Journal of Haematology

Veys, P.A. and Nanduri, V. and Baker, K.S. and He, W. and Bandini, G. and Biondi, A. and Dalissier, A. and Davis, J.H. and Eames, G.M. and Egeler, R.M. and Filipovich, A.H. and Fischer, A. and Jrgens, H. and Krance, R. and Lanino, E. and Leung, W.H. and Matthes, S. and Michel, G. and Orchard, P.J. and Pieczonka, A. and Ringdn, O. and Schlegel, P.G. and Sirvent, A. and Vettenranta, K. and Eapen, M.

DOI: 10.1111/bjh.13347

Transplantation outcomes for severe combined immunodeficiency, 2000-2009

New England Journal of Medicine

Pai, S.-Y. and Logan, B.R. and Griffith, L.M. and Buckley, R.H. and Parrott, R.E. and Dvorak, C.C. and Kapoor, N. and Hanson, I.C. and Filipovich, A.H. and Jyonouchi, S. and Sullivan, K.E. and Small, T.N. and Burroughs, L. and Skoda-Smith, S. and Haight, A.E. and Grizzle, A. and Pulsipher, M.A. and Chan, K.W. and Fuleihan, R.L. and Haddad, E. and Loechelt, B. and Aquino, V.M. and Gillio, A. and Davis, J. and Knutsen, A. and Smith, A.R. and Moore, T.B. and Schroeder, M.L. and Goldman, F.D. and Connelly, J.A. and Porteus, M.H. and Xiang, Q. and Shearer, W.T. and Fleisher, T.A. and Kohn, D.B. and Puck, J.M. and Notarangelo, L.D. and Cowan, M.J. and O'Reilly, R.J.

DOI: 10.1056/NEJMoa1401177

Outcomes after Hematopoietic Stem Cell Transplantation for Children with I-Cell Disease

Biology of Blood and Marrow Transplantation

Lund, T.C. and Cathey, S.S. and Miller, W.P. and Eapen, M. and Andreansky, M. and Dvorak, C.C. and Davis, J.H. and Dalal, J.D. and Devine, S.M. and Eames, G.M. and Ferguson, W.S. and Giller, R.H. and He, W. and Kurtzberg, J. and Krance, R. and Katsanis, E. and Lewis, V.A. and Sahdev, I. and Orchard, P.J.

DOI: 10.1016/j.bbmt.2014.06.019

Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency

Journal of Allergy and Clinical Immunology

Dvorak, C.C. and Hassan, A. and Slatter, M.A. and Hnig, M. and Lankester, A.C. and Buckley, R.H. and Pulsipher, M.A. and Davis, J.H. and Gngr, T. and Gabriel, M. and Bleesing, J.H. and Bunin, N. and Sedlacek, P. and Connelly, J.A. and Crawford, D.F. and Notarangelo, L.D. and Pai, S.-Y. and Hassid, J. and Veys, P. and Gennery, A.R. and Cowan, M.J.

DOI: 10.1016/j.jaci.2014.06.021

Outcomes of Allogeneic Hematopoietic cell transplantation in patients with Dyskeratosis Congenita

Biology of Blood and Marrow Transplantation

Gadalla, S.M. and Sales-Bonfim, C. and Carreras, J. and Alter, B.P. and Antin, J.H. and Ayas, M. and Bodhi, P. and Davis, J. and Davies, S.M. and Deconinck, E. and Deeg, H.J. and Duerst, R.E. and Fasth, A. and Ghavamzadeh, A. and Giri, N. and Goldman, F.D. and Kolb, E.A. and Krance, R. and Kurtzberg, J. and Leung, W.H. and Srivastava, A. and Or, R. and Richman, C.M. and Rosenberg, P.S. and Toledo Codina, J.S.D. and Shenoy, S. and Soci, G. and Tolar, J. and Williams, K.M. and Eapen, M. and Savage, S.A.

DOI: 10.1016/j.bbmt.2013.05.021

Dexmedetomidine for co-analgesia in chemotherapy-induced severe enterocolitis

Paediatric Anaesthesia

Winton, P. and Whyte, E. and Reimer, E.J. and Davis, J. and Whyte, S.

DOI: 10.1111/j.1460-9592.2011.03575.x

Leukemic transformation of anaplastic large-cell lymphoma

Blood

Vawda, A. and Davis, J. and Vercauteren, S.

DOI: 10.1182/blood-2010-11-318048

Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency

Clinical Immunology

Cuvelier, G.D.E. and Schultz, K.R. and Davis, J. and Hirschfeld, A.F. and Junker, A.K. and Tan, R. and Turvey, S.E.

DOI: 10.1016/j.clim.2009.01.003

Allogeneic hematopoietic stem-cell transplantation for leukocyte adhesion deficiency

Pediatrics

Qasim, W. and Cavazzana-Calvo, M. and Davies, E.G. and Davis, J. and Duval, M. and Eames, G. and Farinha, N. and Filopovich, A. and Fischer, A. and Friedrich, W. and Gennery, A. and Heilmann, C. and Landais, P. and Horwitz, M. and Porta, F. and Sedlacek, P. and Seger, R. and Slatten, M. and Teague, L. and Eapen, M. and Veys, P.

DOI: 10.1542/peds.2008-1191

Improving patient safety by design - A new spinal/intrathecal injection safety system [4]

Canadian Journal of Anesthesia

Sheppard, I. and Davis, J. and Blackstock, D.

DOI: 10.1007/bf03021540

Detection of a novel nonsense mutation in the interleukin 2 receptor gene causing X-linked severe combined immunodeficiency [2]

Annals of Allergy, Asthma and Immunology

Cohen, L. and Hirschfeld, A.F. and Junker, A.K. and Davis, J. and Turvey, S.E.

DOI: 10.1016/S1081-1206(10)63563-6

Torticollis as a sign of cervico-thoracic epidural haematoma in an infant with severe haemophilia A

Haemophilia

Cuvelier, G.D.E. and Davis, J.H. and Purves, E.C. and Wu, J.K.

DOI: 10.1111/j.1365-2516.2006.01323.x

Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita

Blood

H. Ly

DOI: 10.1182/blood-2005-01-0247

08 / 2005

Cytomegalovirus prophylaxis and treatment after hematopoietic stem cell transplantation in Canada: A description of current practices and comparison with Centers for Disease Control/Infectious Diseases Society of America/American Society for Blood and Marrow Transplantation guideline recommendations

Biology of Blood and Marrow Transplantation

Fraser, G.A.M. and Walker, I.I. and Russell, J. and Larratt, L. and Davis, J. and Hogge, D. and Voralia, M. and Rubinger, M. and Schroeder, M. and Walker, I. and Doyle, J. and Messner, H. and Berinstein, N. and Howson-Jan, K. and Lopez, P. and Huebsch, I. and Moquin, J.-P. and Roy, J. and Champagne, M. and Laneuville, P. and Mitchell, D. and Lachance, S. and Cantin, G. and Couture, F. and Couban, S. and Duggan, P.

DOI: 10.1016/j.bbmt.2003.10.007

Second malignancy following high-dose therapy and autologous stem cell transplantation: Incidence and risk factor analysis

Bone Marrow Transplantation

Forrest, D.L. and Nevill, T.J. and Naiman, S.C. and Le, A. and Brockington, D.A. and Barnett, M.J. and Lavoie, J.C. and Nantel, S.H. and Song, K.W. and Shepherd, J.D. and Sutherland, H.J. and Toze, C.L. and Davis, J.H. and Hogge, D.E.

DOI: 10.1038/sj.bmt.1704243

Non-resectable congenital tumors with the ETV6-NTRK3 gene fusion are highly responsive to chemotherapy

Medical and Pediatric Oncology

McCahon, E. and Sorensen, P.H.B. and Davis, J.H. and Rogers, P.C.J. and Schultz, K.R.

DOI: 10.1002/mpo.10272

The North American Immune Tolerance Registry: Practices, outcomes, outcome predictors

Thrombosis and Haemostasis

DiMichele, D.M. and Kroner, B.L. and Adair, S. and Addiego, J. and Anderson, V. and Barbosa, J. and Blatt, P. and Bockenstedt, P. and Castle, V. and Chenaille, P. and Cohen, J. and Czapek, E. and Davis, J. and Davignon, G. and De Alarcon, P. and Dubowy, R. and DuCore, J. and Dugdale, M. and Ewenstein, B. and Fahner, J. and Gribble, T.J. and Gnarra, D. and Gruppo, R. and Hakami, N. and Hanna, M. and Hanna, W. and Haut, P. and Heggie, G. and Homans, A. and Hutter, J. and Johnson, C. and Kajani, M. and Karpatkin, M. and Kasper, C. and Katz, J. and Kessler, C. and Key, N. and Koerper, M. and Konkle, B. and Kosinski, R. and Lazerson, J. and Lightsey, A. and Loew, T. and Lusher, J. and MacLaughlin, W. and Manco-Johnson, M. and Manno, C. and McRedmond, K. and Phatak, P. and Powell, J. and Ragni, M. and Rosenfield, C. and Sanders, J. and Santiago-Borrero, P. and Saidi, P. and Seeler, R. and Seremetis, S. and Sexauer, J. and Travis, S. and Valdez, L. and Warner, E. and White, G. and Barrand, D. and Drown, J. and Herst, J. and Inwood, M. and Lillicrap, D. and Rivard, G. and Rubin, S. and Stranczyniski, H. and Teitel, J.

DOI: 10.1055/s-0037-1612943

Candida dubliniensis fungemia and vascular access infection

Journal of Pediatric Hematology/Oncology

Cimolai, N. and Davis, J. and Trombley, C.

DOI: 10.1097/00043426-200203000-00017

Efficacy and safety of the factor VIII/von Willebrand factor concentrate, Haemate-P/Humate-P: Ristocetin cofactor unit dosing in patients with von Willebrand disease

Thrombosis and Haemostasis

Lillicrap, D. and Poon, M.-C. and Walker, I. and Xie, F. and Schwartz, B.A. and Akabutu, J. and Ali, K. and Barnard, D. and Blanchette, V. and Bond, M. and Carcao, M. and Card, R. and David, M. and Davis, J. and Delorme, M. and Demers, C. and Dolan, S. and Drouin, J. and Garvey, B. and Gill, K. and Growe, G. and Herst, J. and Israels, S. and Lepine-Martin, M. and Luke, K.-H. and McCusker, P. and Pai, M. and Ritchie, B. and Rivard, G. and Robinson, S. and Ross, E. and Rubin, S. and Rubinger, M. and Scully, M.F. and Silva, M. and St.-Louis, J. and Stobart, K. and Teitel, J. and Vickars, L. and Wu, J.

DOI: 10.1055/s-0037-1612977

High-Dose Melphalan, Etoposide, Total-Body Irradiation, and Autologous Stem-Cell Reconstitution as Consolidation Therapy for High-Risk Ewings Sarcoma Does Not Improve Prognosis

Journal of Clinical Oncology

Paul A. Meyers and Mark D. Krailo and Marc Ladanyi and Ka-Wah Chan and Scott L. Sailer and Paul S. Dickman and David L. Baker and Jeffrey H. Davis and Robert B. Gerbing and Alfred Grovas and Cynthia E. Herzog and Karen L. Lindsley and Wen Liu-Mares and James B. Nachman and Lance Sieger and Jean Wadman and Richard G. Gorlick

DOI: 10.1200/jco.2001.19.11.2812

06 / 2001

Diamond-blackfan anemia and cyclosporine therapy revisited

American Journal of Pediatric Hematology/Oncology

Alessandri, A.J. and Rogers, P.C. and Wadsworth, L.D. and Davis, J.H.

DOI: 10.1097/00043426-200003000-00020

Causes of death in Canadians with haemophilia 1980-1995

Haemophilia

Walker, I.R. and Julian, J.A. and Growe, G. and Davis, J. and Vickars, L. and Akabutu, J. and Ritchie, B. and Poon, M.-C. and Wu, J. and Card, R. and Ali, K. and Israels, S. and Rubinger, M. and Stobard, K. and Inwood, M. and McCusker, P. and Walker, I. and Pai, M. and Teitel, J. and Garvey, B. and Blanchette, V. and Giles, A. and Lillicrap, D. and Silva, M. and Drouin, J. and Luke, K.-H. and Gill, K. and Herst, J. and Lepine-Martin, M. and Rivard, G. and Bond, M. and David, M. and St.-Louis, J. and Jobin, F. and Demers, C. and Jardine, L. and Scully, M.-F. and Barnard, D. and Robinson, S. and Rubin, S. and Dolan, S. and Ross, E.

DOI: 10.1046/j.1365-2516.1998.00179.x

Successful use of cyclosporine A in the treatment of refractory thrombotic thrombocytopenic purpura

British Journal of Haematology

Hand, J.P. and Lawlor, E.R. and Yong, C.K.K. and Davis, J.H.

DOI: 10.1046/j.1365-2141.1998.00602.x

Letters to the editor: Reply

Journal of Pediatric Hematology/Oncology

Lawlor, E.R. and Anderson, R.A. and Davis, J.H. and Fryer, C.J.H. and Pritchard, S.L. and Rogers, P.C.J. and Wu, J.K. and Schultz, K.R.

Immunosuppressive therapy: A potential alternative to bone marrow transplantation as initial therapy for acquired severe aplastic anemia in childhood?

American Journal of Pediatric Hematology/Oncology

Lawlor, E.R. and Anderson, R.A. and Davis, J.H. and Fryer, C.J.H. and Pritchard, S.L. and Rogers, P.C.J. and Wu, J.K. and Schultz, K.R.

DOI: 10.1097/00043426-199703000-00004

Erythropoietin therapy in neonates at risk of having bronchopulmonary dysplasia and requiring multiple transfusions

Journal of Pediatrics

Al-Kharfy, T. and Smyth, J.A. and Wadsworth, L. and Krystal, G. and Fitzgerald, C. and Davis, J. and Milner, R.

DOI: 10.1016/S0022-3476(96)70194-4

Intensive conditioning regimen for bone marrow transplantation in children with high-risk haematological malignancies

Medical and Pediatric Oncology

Cole, C.H. and Pritchard, S. and Rogers, P.C.J. and Davis, J.E. and Phillips, G. and Chan, K.W.

DOI: 10.1002/mpo.2950230603

Obstructive lung disease in children after allogeneic bone marrow transplantation

Blood

Schultz, K.R. and Green, G.J. and Wensley, D. and Sargent, M.A. and Magee, J.F. and Spinelli, J.J. and Pritchard, S. and Davis, J.H. and Rogers, P.C.J. and Chan, K.W. and Phillips, G.L.

DOI: 10.1182/blood.v84.9.3212.bloodjournal8493212

Infantile choriocarcinoma. Re-examination of a potentially curable entity

Cancer

Belchis, D.A. and Mowry, J. and Davis, J.H.

DOI: 10.1002/1097-0142(19930915)72:6u003C2028::AID-CNCR2820720639u003E3.0.CO;2-G

Treatment of Malignancy with Unmodified Antibody

Pathology and Immunopathology Research

Christopher C. Badger and Claudio Anasetti and Jeff Davis and Irwin D. Bernstein

DOI: 10.1159/000157067

A study of hematopoietic stem cell transplantation (HSCT) in non-malignant disease using a reduced-intensity preparatory regime with campath-H, fludarabine and malphalan

It is hoped that this study will provide evidence that a preparative regimen consisting of a combination of campath-H, fludarabine and malphalan will maximize host immunosuppression without myeloablation, while being well tolerated and sufficient for engraftment of donor hemopoietic cells when minimally mismatched from the recipient or acquired from unrelated sources. It is postulated that this combination will allow for the gradual transition from recipient chimerism to full donor chimerism with minimal early and delayed toxicity to the recipient. The target is children with non-malignant diseases who are benefited by transplantation and for whom myeloablation is not necessary.

Demonstration of human safety & physician acceptance of a unique spinal injection safety system (SISS)

The inadvertent administration of the wrong drug, by the spinal or epidural route, often with catastrophic results, continues to occur in medical practice. Several Canadian and world reports have demonstrated the tragic consequences in all medical fields utilizing spinal therapies, including oncology, anaesthesiology, and obstetrics. Specific recent cases of death as a result of the maladministration of vinca alkaloids into the spine have been reported widely. We have redesigned the spinal needle and system around intrathecal administration of medications and in this study we propose to implement the spinal injection safety system (SISS) in clinical practice. Through evaluating the SISS we will determine its safety attributes for pediatric patients receiving spinal chemotherapy and whether or not it meets the practice expectations of physicians. We also seek to significantly reduce the net risk of patient harm through inadvertent human error during the spinal drug administration procedure as well as be cost-effective in comparison to current practices.

Honours & Awards

Bruce W Jackson Memorial Award for the Reserve Flight Surgeon of the Year, The Society of United States Naval Flight Surgeons - 2014

Rookie of the Year Attending Award, University of British Columbia Residents - 1992

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Jeffrey Davis

MD, BEng

Investigator Emeritus, BC Children's Hospital

Academic Affiliations

Publications

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The Adverse Event Landscape of Stem Cell Transplant: Evidence for AGVHD Driving Early Transplant Associated Toxicities

Overlap chronic GVHD is associated with adverse survival outcomes compared to classic chronic GVHD

Prospective PTCTC trial of myeloablative haplo-BMT with posttransplant cyclophosphamide for pediatric acute leukemias

Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events

Abatacept for GVHD prophylaxis can reduce racial disparities by abrogating the impact of mismatching in unrelated donor stem cell transplantation

Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD

Ifosfamide, gemcitabine, and vinorelbine is an effective salvage regimen with excellent stem cell mobilization in relapsed or refractory pediatric Hodgkin lymphoma

PTPRD copy number variants and Ewing's sarcoma: Strengthening the association and therapeutic implications

Immune Reconstitution and Infection Patterns after Early Alemtuzumab and Reduced Intensity Transplantation for Nonmalignant Disorders in Pediatric Patients

Outcomes of Measurable Residual Disease in Pediatric Acute Myeloid Leukemia before and after Hematopoietic Stem Cell Transplant: Validation of Difference from Normal Flow Cytometry with Chimerism Studies and Wilms Tumor 1 Gene Expression

Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes

SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery

Health-Related Quality of Life in Survivors of High-Risk Neuroblastoma After Stem Cell Transplant: A National Population-Based Perspective

Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation

Hematopoietic Cell Transplantation Using Reduced-Intensity Conditioning Is Successful in Children with Hematologic Cytopenias of Genetic Origin

Haematopoietic stem cell transplantation for refractory Langerhans cell histiocytosis: Outcome by intensity of conditioning

Transplantation outcomes for severe combined immunodeficiency, 2000-2009

Outcomes after Hematopoietic Stem Cell Transplantation for Children with I-Cell Disease

Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency

Outcomes of Allogeneic Hematopoietic cell transplantation in patients with Dyskeratosis Congenita

Dexmedetomidine for co-analgesia in chemotherapy-induced severe enterocolitis

Leukemic transformation of anaplastic large-cell lymphoma

Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency

Allogeneic hematopoietic stem-cell transplantation for leukocyte adhesion deficiency

Improving patient safety by design - A new spinal/intrathecal injection safety system [4]

Detection of a novel nonsense mutation in the interleukin 2 receptor gene causing X-linked severe combined immunodeficiency [2]

Torticollis as a sign of cervico-thoracic epidural haematoma in an infant with severe haemophilia A

Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita

Second malignancy following high-dose therapy and autologous stem cell transplantation: Incidence and risk factor analysis

Non-resectable congenital tumors with the ETV6-NTRK3 gene fusion are highly responsive to chemotherapy

The North American Immune Tolerance Registry: Practices, outcomes, outcome predictors

Candida dubliniensis fungemia and vascular access infection

Efficacy and safety of the factor VIII/von Willebrand factor concentrate, Haemate-P/Humate-P: Ristocetin cofactor unit dosing in patients with von Willebrand disease

High-Dose Melphalan, Etoposide, Total-Body Irradiation, and Autologous Stem-Cell Reconstitution as Consolidation Therapy for High-Risk Ewings Sarcoma Does Not Improve Prognosis

Diamond-blackfan anemia and cyclosporine therapy revisited

Causes of death in Canadians with haemophilia 1980-1995

Successful use of cyclosporine A in the treatment of refractory thrombotic thrombocytopenic purpura

Letters to the editor: Reply

Immunosuppressive therapy: A potential alternative to bone marrow transplantation as initial therapy for acquired severe aplastic anemia in childhood?

Erythropoietin therapy in neonates at risk of having bronchopulmonary dysplasia and requiring multiple transfusions

Intensive conditioning regimen for bone marrow transplantation in children with high-risk haematological malignancies

Obstructive lung disease in children after allogeneic bone marrow transplantation

Infantile choriocarcinoma. Re-examination of a potentially curable entity

Treatment of Malignancy with Unmodified Antibody

Research

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A study of hematopoietic stem cell transplantation (HSCT) in non-malignant disease using a reduced-intensity preparatory regime with campath-H, fludarabine and malphalan

Demonstration of human safety & physician acceptance of a unique spinal injection safety system (SISS)

Honours & Awards

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