Publications

Associations between epigenetic aging and childhood peer victimization, depression, and suicidal ideation in adolescence and adulthood: A study of two population-based samples
Frontiers in Cell and Developmental Biology
L. C. Perret and M-C. Geoffroy and E. Barr and F. Parnet and N. Provencal and M. Boivin and K. J. O’Donnell and M. Suderman and C. Power and G. Turecki and I. Ouellet-Morin
DOI: 10.3389/fcell.2022.1051556
01/2023

Association between child maltreatment and depressive symptoms in emerging adulthood: The mediating and moderating roles of DNA methylation
PLoS ONE
Comtois-Cabana, M. and Barr, E. and Proven?al, N. and Ouellet-Morin, I.
DOI: 10.1371/journal.pone.0280203
2023

Combined effects of genotype and childhood adversity shape variability of DNA methylation across age
Translational Psychiatry
Czamara, D. and Tissink, E. and Tuhkanen, J. and Martins, J. and Awaloff, Y. and Drake, A.J. and Khulan, B. and Palotie, A. and Winter, S.M. and Nemeroff, C.B. and Craighead, W.E. and Dunlop, B.W. and Mayberg, H.S. and Kinkead, B. and Mathew, S.J. and Iosifescu, D.V. and Neylan, T.C. and Heim, C.M. and Lahti, J. and Eriksson, J.G. and Räikkönen, K. and Ressler, K.J. and Proven?al, N. and Binder, E.B.
DOI: 10.1038/s41398-020-01147-z
2021

A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders.
Neurobiology of stress
Suarez A and Lahti J and Lahti-Pulkkinen M and Girchenko P and Czamara D and Arloth J and Malmberg AL and Hämäläinen E and Kajantie E and Laivuori H and Villa PM and Reynolds RM and Räikkönen K
DOI: 10.1016/j.ynstr.2020.100275
PubMed: 33344728
11/2020

Intergenerational Effects of Maternal Holocaust Exposure on FKBP5 Methylation.
The American journal of psychiatry
Bierer LM and Bader HN and Daskalakis NP and Lehrner A and Provençal N and Wiechmann T and Klengel T and Makotkine I and Binder EB and Yehuda R
DOI: 10.1176/appi.ajp.2019.19060618
PubMed: 32312110
04/2020

Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms
Journal of Psychiatric Research
Thomas, M. and Coope, A. and Falkenberg, C. and Dunlop, B.W. and Czamara, D. and Provencal, N. and Craighead, W.E. and Mayberg, H.S. and Nemeroff, C.B. and Binder, E.B. and Nieratschker, V.
DOI: 10.1016/j.jpsychires.2019.10.019
2020

Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation
Proceedings of the National Academy of Sciences of the United States of America
Proven?al, N. and Arloth, J. and Cattaneo, A. and Anacker, C. and Cattane, N. and Wiechmann, T. and Röh, S. and Ködel, M. and Klengel, T. and Czamara, D. and Müller, N.S. and Lahti, J. and Räikkönen, K. and Pariante, C.M. and Binder, E.B.
DOI: 10.1073/pnas.1820842116
2020

Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
Clinical Epigenetics
DOI: 10.1186/s13148-019-0682-5
12/2019

Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness
Psychoneuroendocrinology
DOI: 10.1016/j.psyneuen.2019.01.013
05/2019

A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment
Journal of the American Academy of Child & Adolescent Psychiatry
DOI: 10.1016/j.jaac.2019.03.006
03/2019

DRD4 methylation as a potential biomarker for physical aggression: An epigenome-wide, cross-tissue investigation
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
DOI: 10.1002/ajmg.b.32689
12/2018

HAM-TBS: high-accuracy methylation measurements via targeted bisulfite sequencing
Epigenetics & Chromatin
DOI: 10.1186/s13072-018-0209-x
12/2018

Central Neuroepigenetic Regulation of the Hypothalamic-Pituitary-Adrenal Axis.
Progress in molecular biology and translational science
DOI: 10.1016/bs.pmbts.2018.04.006
PubMed: 30072050
06/2018

Corrigendum: Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants.
Frontiers in endocrinology
DOI: 10.3389/fendo.2018.00047
PubMed: 29507579
02/2018

From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health
Progress in Molecular Biology and Translational Science
DOI: 10.1016/bs.pmbts.2018.04.011
2018

Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study
Development and Psychopathology
Madeline B. Harms and Rasmus Birn and Nadine Provencal and Tobias Wiechmann and Elisabeth B. Binder and Sebastian W. Giakas and Barbara J. Roeber and Seth D. Pollak
DOI: 10.1017/s095457941700147x
11/2017

Epigenetic effects of glucocorticoids exposure during hippocampal neurogenesis and their implication in psychiatric disorders
European Neuropsychopharmacology
N. Provençal and J. Arloth and A. Cattaneo and C. Anacker and T. Klengel and C. Pariante and E. Binder
DOI: 10.1016/s0924-977x(17)31059-3
10/2017

Dynamic DNA methylation changes in the oxytocin locus (OXT) during pregnancy are associated with maternal parenting behavior
Psychoneuroendocrinology
Philipp Toepfer and Kieran J. ÓDonnell and Christine M. Heim and David T.S. Lin and Julia L. MacIsaac and Michael S. Kobor and Michael J. Meaney and Nadine Provencal and Elisabeth B. Binder and Sonja Entringer and Pathik D. Wadhwa and Claudia Buss
DOI: 10.1016/j.psyneuen.2017.07.306
09/2017

HAM-TBS: High accuracy methylation measurements via targeted bisulfite sequencing
Simone Roeh and Nadine Provencal and Tobias Wiechmann and Maik Koedel and Susann Sauer and Elisabeth B. Binder
DOI: 10.1101/163535
07/2017

Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: A prospective longitudinal study
Development and Psychopathology
Harms, M.B. and Birn, R. and Provencal, N. and Wiechmann, T. and Binder, E.B. and Giakas, S.W. and Roeber, B.J. and Pollak, S.D.
DOI: 10.1017/S095457941700147X
2017

How Can GxE Research Help Prevent the Development of Chronic Physical Aggression?
Gene-Environment Transactions in Developmental Psychopathology
DOI: 10.1007/978-3-319-49227-8_10
2017

A variation in the oxytocin receptor gene moderates the relationship between early maternal care in childhood and interleukin 6 (IL-6) concentrations during pregnancy
Psychoneuroendocrinology
Philipp Toepfer and Christine M. Heim and Sonja Entringer and Pathik D. Wadhwa and Nadine Provencal and Elisabeth B. Binder and Claudia Buss
DOI: 10.1016/j.psyneuen.2016.07.049
09/2016

Epigenetic mechanisms involved in the effects of stress exposure: focus on 5-hydroxymethylcytosine: Table 1:
Environmental Epigenetics
Laura M. Hack and Alec L.W. Dick and Nadine Provençal
DOI: 10.1093/eep/dvw016
08/2016

The impact of environmental stressors on dna methylation, neurobehavioral development, and chronic physical aggression: Prospects for early protective interventions
Molecular and Integrative Toxicology
Tremblay, R.E. and Booij, L. and Proven?al, N. and Szyf, M.
DOI: 10.1007/978-3-319-27449-2_10
2016

Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants
Frontiers in Endocrinology
Chinthika Piyasena and Jessy Cartier and Nadine Provençal and Tobias Wiechmann and Batbayar Khulan and Raju Sunderesan and Gopi Menon and Jonathan R. Seckl and Rebecca M. Reynolds and Elisabeth B. Binder and Amanda J. Drake
DOI: 10.3389/fendo.2016.00158
2016

Alterations in DNA Methylation and Hydroxymethylation Due to Parental Care in Rhesus Macaques
Epigenetics and Neuroendocrinology
DOI: 10.1007/978-3-319-24493-8_7
2016

Impact of Early Environment on Children's Mental Health: Lessons From DNA Methylation Studies With Monozygotic Twins
Twin Research and Human Genetics
Julian Chiarella and Richard E. Tremblay and Moshe Szyf and Nadine Provençal and Linda Booij
DOI: 10.1017/thg.2015.84
11/2015

Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions
Biological Psychiatry
Anthony S. Zannas and Nadine Provençal and Elisabeth B. Binder
DOI: 10.1016/j.biopsych.2015.04.003
09/2015

The effects of early life stress on the epigenome: From the womb to adulthood and even before
Experimental Neurology
Nadine Provençal and Elisabeth B. Binder
DOI: 10.1016/j.expneurol.2014.09.001
06/2015

The neurobiological effects of stress as contributors to psychiatric disorders: focus on epigenetics
Current Opinion in Neurobiology
Nadine Provencal and Elisabeth B Binder
DOI: 10.1016/j.conb.2014.08.007
02/2015

The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity
Journal of Experimental Biology
N. Provencal and L. Booij and R. E. Tremblay
DOI: 10.1242/jeb.111401
01/2015

Hydroxymethylation and DNA methylation profiles in the prefrontal cortex of the non-human primate rhesus macaque and the impact of maternal deprivation on hydroxymethylation
Neuroscience
R. Massart and M. Suderman and N. Provencal and C. Yi and A.J. Bennett and S. Suomi and M. Szyf
DOI: 10.1016/j.neuroscience.2014.03.021
05/2014

Association of Childhood Chronic Physical Aggression with a DNA Methylation Signature in Adult Human T Cells
PLoS ONE
Nadine Provençal and Matthew J. Suderman and Claire Guillemin and Frank Vitaro and Sylvana M. Côté and Michael Hallett and Richard E. Tremblay and Moshe Szyf
DOI: 10.1371/journal.pone.0089839
04/2014

DNA Methylation Signature of Childhood Chronic Physical Aggression in T Cells of Both Men and Women
PLoS ONE
Claire Guillemin and Nadine Provençal and Matthew Suderman and Sylvana M. Côté and Frank Vitaro and Michael Hallett and Richard E. Tremblay and Moshe Szyf
DOI: 10.1371/journal.pone.0086822
01/2014

Epigenetics in Posttraumatic Stress Disorder
Epigenetics and Neuroplasticity—Evidence and Debate
Carina Rampp and Elisabeth B. Binder and Nadine Provençal
DOI: 10.1016/b978-0-12-800977-2.00002-4
2014

Epigenetics in posttraumatic stress disorder
Progress in Molecular Biology and Translational Science
Rampp, C. and Binder, E.B. and Proven?al, N.
DOI: 10.1016/B978-0-12-800977-2.00002-4
2014

Differential DNA Methylation Regions in Cytokine and Transcription Factor Genomic Loci Associate with Childhood Physical Aggression
PLoS ONE
Nadine Provençal and Matthew J. Suderman and Doretta Caramaschi and Dongsha Wang and Michael Hallett and Frank Vitaro and Richard E. Tremblay and Moshe Szyf
DOI: 10.1371/journal.pone.0071691
08/2013

Childhood Chronic Physical Aggression Associates with Adult Cytokine Levels in Plasma
PLoS ONE
Nadine Provençal and Matthew J. Suderman and Frank Vitaro and Moshe Szyf and Richard E. Tremblay
DOI: 10.1371/journal.pone.0069481
07/2013

The Signature of Maternal Rearing in the Methylome in Rhesus Macaque Prefrontal Cortex and T Cells
Journal of Neuroscience
N. Provencal and M. J. Suderman and C. Guillemin and R. Massart and A. Ruggiero and D. Wang and A. J. Bennett and P. J. Pierre and D. P. Friedman and S. M. Cote and M. Hallett and R. E. Tremblay and S. J. Suomi and M. Szyf
DOI: 10.1523/jneurosci.1470-12.2012
10/2012

Peripheral SLC6A4 DNA Methylation Is Associated with In Vivo Measures of Human Brain Serotonin Synthesis and Childhood Physical Aggression
PLoS ONE
Dongsha Wang and Moshe Szyf and Chawki Benkelfat and Nadine Provençal and Gustavo Turecki and Doretta Caramaschi and Sylvana M. Côté and Frank Vitaro and Richard E. Tremblay and Linda Booij
DOI: 10.1371/journal.pone.0039501
06/2012

The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells
Journal of Neuroscience
Proven?al, N. and Suderman, M.J. and Guillemin, C. and Massart, R. and Ruggiero, A. and Wang, D. and Bennett, A.J. and Pierre, P.J. and Friedman, D.P. and Côté, S.M. and Hallett, M. and Tremblay, R.E. and Suomi, S.J. and Szyf, M.
DOI: 10.1523/JNEUROSCI.1470-12.2012
2012

Epigenetics and behaviour
Development and Prevention of Behaviour Problems: From Genes to Social Policy
Szyf, M. and Weaver, I. and Provencal, N. and McGowan, P.O. and Tremblay, R.E. and Meaney, M.J.
DOI: 10.4324/9780203868706
2009

HOW DOES EARLY LIFE SOCIAL ENVIRONMENT SCULPT OUR GENES?
Biology of Reproduction
Moshe Szyf and Ian C.G. Weaver and Nadine Provencal and Patrick McGowan and Gustavo Turecki and Richard Tremblay and Michael Meaney
DOI: 10.1093/biolreprod/77.s1.64
07/2007

Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines
Biochemical Pharmacology
Jing-Ni Ou and Jérôme Torrisani and Alexander Unterberger and Nadine Provençal and Keisuke Shikimi and Mohsen Karimi and Tomas J. Ekström and Moshe Szyf
DOI: 10.1016/j.bcp.2006.12.032
05/2007

Analysis of a variable number tandem repeat polymorphism in the huntingtin interacting protein-1 related gene for anticipation in bipolar affective disorder.
Progress in neuro-psychopharmacology & biological psychiatry
Provençal N and Shink E and Harvey M and Tremblay M and Barden N
DOI: 10.1016/j.pnpbp.2004.07.001
PubMed: 15588756
12/2004

Research
Grants

Bell Grant

Access to the Signature Biobank 2015-2016

Brain & Behavior Research Foundation

NARSAD Young Investigator Grant 2017-2019

Honours & Awards

Fellowship Award, Canadian Institute of Health Research (CIHR) 2015-2017

Richard Todd Award, International Society of Psychiatric Genetics 2014

Research Group Members

Emily Barr, PhD Student
Maude Comtois-Cabana, PhD candidate