BCCHR Researchers Find a Researcher

Rachel Eddy

PhD

Investigator, BC Children's Hospital

The focus of my research is to better understand lung disease, and potential risks for lung disease, in children that can then be used to better treat patients and potentially stop lung disease from developing or advancing. To do this, we develop and apply new non-invasive medical imaging tools to deeply measure lung structure and function. We primarily use magnetic resonance imaging (MRI), which allows us to safely scan people multiple times and measure unique aspects of lung function that are not possible using any other clinical or imaging tool.

Academic Affiliations

Assistant Professor, , Department of Radiology, Faculty of Medicine, University of British Columbia
Assistant Professor, , Department of Pediatrics, Faculty of Medicine, University of British Columbia
Research Theme: Childhood Diseases
Research Group(s): Clinical Practice, Outcomes and Innovation; Rare Diseases

Contact Information

Location

950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4

rachel.eddy@bcchr.ca

Heterogeneity of short-term elexacaftor-tezacaftor-ivacaftor response in cystic fibrosis using 129Xe MRI

Thorax

Rachel L Eddy and Vanessa M Diamond and Josie Chrenek and Girija Bhatnagar and David Sag and Rana Ghadymimahani and Amreen Aulakh and Britney X Ha and Bradley S Quon and Jonathan H Rayment

DOI: 10.1136/thorax-2025-223687

12 / 2025

Utility of Hyperpolarized 129-Xenon MRI in Primary Ciliary Dyskinesia

ERJ Open Research

Wallace B. Wee and Brandon Zanette and Samal Munidasa and Rachel L. Eddy and Jonathan H Rayment and Teresa To and Felix Ratjen and Giles Santyr and Sharon D. Dell

DOI: 10.1183/23120541.01105-2025

10 / 2025

Integration of mass cytometry and single-cell RNA-sequencing of cells in bronchoalveolar lavage

Biotechniques

Guinto, E. and Chopra, S. and Kuo, I.-C. and Shin, S.B. and Messing, M. and Cheung, C.Y. and Yang, J.S.W. and Gerayeli, F.V. and Yip, W. and Milne, S. and Eddy, R.L. and Leung, J.M. and McNagny, K.M. and Sin, D.D.

DOI: 10.1080/07366205.2025.2505347

The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: Protocol for a prospective, observational cohort study

BMJ Open

Burns, P. and Eddy, R.L. and Li, X. and Yang, J. and Dhillon, S.S. and Couillard, S. and Stickland, M.K. and Guenette, J. and Svenningsen, S. and Tulloch, T. and Samji, H. and Meza, R. and Struik, L.L. and Aaron, S. and Ho, T. and Lam, S. and Leipsic, J. and MacLean, J. and Afshar, T. and Moraes, T.J. and Zanette, B. and Santyr, G. and Counil, F.-P. and Hernandez Cordero, A.I. and Matano, S. and De Arruda Maluf, G. and Leung, C. and Feng, C. and Bal, L. and Dhaliwal, H. and Mumuni, A. and Lui, C. and Drew, H. and Sin, D.D. and Rayment, J.H. and Leung, J.M.

DOI: 10.1136/bmjopen-2025-100568

A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging

Journal of Magnetic Resonance Imaging

Diamond, V.M. and Bell, L.C. and Bone, J.N. and Driehuys, B. and Menchaca, M. and Santyr, G. and Svenningsen, S. and Thomen, R.P. and Marshall, H. and Smith, L.J. and Collier, G.J. and Wild, J.M. and Woods, J.C. and Fain, S.B. and Eddy, R.L. and Rayment, J.H.

DOI: 10.1002/jmri.29746

Make it count with photon-counting computed tomography: a revolution in technology for investigating the airways

European Respiratory Journal

Eddy, R.L. and Sin, D.D.

DOI: 10.1183/13993003.00297-2025

Transcriptomic profiling of the airway epithelium in COPD links airway eosinophilia to type 2 inflammation and corticosteroid response

European Respiratory Journal

Leung, C. and Park, H.Y. and Li, X. and Koelwyn, G.J. and Tuong, J. and Vahedi, S.M. and Leitao Filho, F.S. and Yang, J.S. and Eddy, R.L. and Milne, S. and Ryu, M.H. and Takiguchi, H. and Akata, K. and Ra, S.W. and Moon, J.-Y. and Kim, H.K. and Cho, Y. and Yamasaki, K. and van Eeden, S.F. and Shaipanich, T. and Lam, S. and Leung, J.M. and Sin, D.D.

DOI: 10.1183/13993003.01875-2024

Quantification of 129Xe MRI Ventilation-defect-percent Using Binary-threshold, Gaussian Linear-Binning and K-means Methods: Differences in Asthma and COPD

Academic Radiology

Durom, E. and Yang, C. and Mozaffaripour, A. and Matheson, A.M. and Eddy, R.L. and Svenningsen, S. and Parraga, G.

DOI: 10.1016/j.acra.2025.04.030

Hyperpolarized129XE MRI and Spectroscopy: Quantitative Measurements, Results, and Emerging Opportunities

Radiology Cardiothoracic Imaging

Schmidt, A. and Liggins, J.A. and Bhutta, H. and Dell, S.D. and Leung, J.M. and Sin, D.D. and Leipsic, J.A. and Rayment, J.H. and Eddy, R.L.

DOI: 10.1148/ryct.240562

Three-Dimensional Free-Breathing Ultrashort Echo Time (UTE) 1H MRI Regional Ventilation: Comparison With Hyperpolarized 129Xe MRI and Pulmonary Function Testing in Healthy Volunteers and People With Cystic Fibrosis

NMR in Biomedicine

Tan, F. and Eddy, R. and Diamond, V. and Rayment, J. and Larson, P.

DOI: 10.1002/nbm.70033

Pulmonary 129Xe MRI: CNN Registration and Segmentation to Generate Ventilation Defect Percent with Multi-center Validation

Academic Radiology

Mozaffaripour, A. and Matheson, A.M. and Rahman, O. and Sharma, M. and Kooner, H.K. and McIntosh, M.J. and Rayment, J. and Eddy, R.L. and Svenningsen, S. and Parraga, G.

DOI: 10.1016/j.acra.2024.10.029

Following, Seeing, and Understanding: Longitudinal Magnetic Resonance Imaging in Children with Cystic Fibrosis

Annals of the American Thoracic Society

Eddy, R.L. and Parraga, G.

DOI: 10.1513/AnnalsATS.202411-1148ED

Loss of Lung Function Led to Loss of Life during the COVID-19 Pandemic

American Journal of Respiratory and Critical Care Medicine

Eddy, R.L. and Sin, D.D.

DOI: 10.1164/rccm.202503-0695ED

Airway Mucus in Older People Without Chronic Respiratory Illness

CHEST

Harkiran K. Kooner and Hana Serajeddini and Rachel L. Eddy and Cory Yamashita and Sarah Svenningsen and Grace Parraga

DOI: 10.1016/j.chest.2024.04.023

09 / 2024

Cluster analysis to identify long COVID phenotypes using129Xe magnetic resonance imaging: a multicentre evaluation

European Respiratory Journal

Rachel L. Eddy and David Mummy and Shuo Zhang and Haoran Dai and Aryil Bechtel and Alexandra Schmidt and Bradie Frizzell and Firoozeh V. Gerayeli and Jonathon A. Leipsic and Janice M. Leung and Bastiaan Driehuys and Loretta G. Que and Mario Castro and Don D. Sin and Peter J. Niedbalski

DOI: 10.1183/13993003.02301-2023

03 / 2024

129Xe MRI and Oscillometry of Irritant-Induced Asthma After Bronchial Thermoplasty

CHEST

Marrissa J. McIntosh and Joseph J. Hofmann and Harkiran K. Kooner and Rachel L. Eddy and Grace Parraga and Constance A. Mackenzie

DOI: 10.1016/j.chest.2023.09.010

02 / 2024

New physiological measurements in COPD

ERS Monograph

Milne, S. and Tonga, K.O. and Eddy, R.L. and Thompson, B.R. and Thamrin, C. and King, G.G.

DOI: 10.1183/2312508X.10006923

Single-cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID

European Respiratory Journal

Gerayeli, F.V. and Park, H.Y. and Milne, S. and Li, X. and Yang, C.X. and Tuong, J. and Eddy, R.L. and Vahedi, S.M. and Guinto, E. and Cheung, C.Y. and Yang, J.S.W. and Gilchrist, C. and Yehia, D. and Stach, T. and Dang, H. and Leung, C. and Shaipanich, T. and Leipsic, J. and Koelwyn, G.J. and Leung, J.M. and Sin, D.D.

DOI: 10.1183/13993003.01947-2023

A proposed approach to pulmonary long COVID: a viewpoint

European Respiratory Journal

Gerayeli, F.V. and Eddy, R.L. and Sin, D.D.

DOI: 10.1183/13993003.02302-2023

Single cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID

medRxiv

Gerayeli, F.V. and Park, H.Y. and Milne, S. and Li, X. and Yang, C.X. and Tuong, J. and Eddy, R.L. and Guinto, E. and Cheung, C.Y. and Yang, J.S.W. and Gilchrist, C. and Abbas, D. and Stach, T. and Leung, C. and Shaipanich, T. and Leipsic, J. and Koelwyn, G. and Leung, J.M. and Sin, D.D.

DOI: 10.1101/2024.02.26.24302674

Mild airways obstruction: Spirometric diagnostic pitfalls and solutions

Current Opinion in Pulmonary Medicine

Alotaibi, N.M. and Eddy, R.L. and Sin, D.D.

DOI: 10.1097/MCP.0000000000001023

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Journal of Visualized Experiments

Eddy, R.L. and Xu, G.H. and Leipsic, J.A. and Leung, J.M. and Sin, D.D. and Hall, C.S. and Tam, R.C.

DOI: 10.3791/66257

Power Outage: Mitochondrial Dysfunction in Long COVID Measured Using 1H and 31P MR Spectroscopy

Radiology

Parraga, G. and Eddy, R.L.

DOI: 10.1148/radiol.242833

Missing airways, ventilation defects and conductive airway physiology in asthma

The European respiratory journal

Verbanck, S. and Eddy, R.L. and McIntosh, M.J. and Parraga, G. and Foy, B.H.

DOI: 10.1183/13993003.00242-2024

Pulmonary Vascular Differences in Eosinophilic Asthma after 2.5 Years of Anti"IL-5Ra Treatment

American Journal of Respiratory and Critical Care Medicine

McIntosh, M.J. and Matheson, A.M. and Kooner, H.K. and Eddy, R.L. and Serajeddini, H. and Yamashita, C. and Parraga, G.

DOI: 10.1164/rccm.202305-0849LE

Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis

European Respiratory Review

Guinto, E. and Gerayeli, F.V. and Eddy, R.L. and Lee, H. and Milne, S. and Sin, D.D.

DOI: 10.1183/16000617.0253-2022

129Xe MRI Ventilation Defects in Asthma: What is the Upper Limit of Normal and Minimal Clinically Important Difference?

Academic Radiology

McIntosh, M.J. and Biancaniello, A. and Kooner, H.K. and Bhalla, A. and Serajeddini, H. and Yamashita, C. and Parraga, G. and Eddy, R.L.

DOI: 10.1016/j.acra.2023.03.010

CT Mucus Score and 129Xe MRI Ventilation Defects After 2.5 Years Anti-IL-5Ra in Eosinophilic Asthma

Chest

McIntosh, M.J. and Kooner, H.K. and Eddy, R.L. and Wilson, A. and Serajeddini, H. and Bhalla, A. and Licskai, C. and Mackenzie, C.A. and Yamashita, C. and Parraga, G.

DOI: 10.1016/j.chest.2023.02.009

PulmonaryMRIand Cluster Analysis Help Identify Novel Asthma Phenotypes

Journal of Magnetic Resonance Imaging

Rachel L. Eddy and Marrissa J. McIntosh and Alexander M. Matheson and David G. McCormack and Christopher Licskai and Grace Parraga

DOI: 10.1002/jmri.28152

11 / 2022

A Soft Labeling Approach to Develop Automated Algorithms that Incorporate Uncertainty in Pulmonary Opacification on Chest CT using COVID-19 Pneumonia

Academic Radiology

Keegan Lensink and Fu (Jorden) Lo and Rachel L. Eddy and Marco Law and Issam Laradji and Eldad Haber and Savvas Nicolaou and Darra Murphy and William A. Parker

DOI: 10.1016/j.acra.2022.03.025

07 / 2022

Pulmonary functional MRI: Detecting the structure"function pathologies that drive asthma symptoms and quality of life

Respirology

Kooner, H.K. and McIntosh, M.J. and Desaigoudar, V. and Rayment, J.H. and Eddy, R.L. and Driehuys, B. and Parraga, G.

DOI: 10.1111/resp.14197

Asthma Control, Airway Mucus, and 129Xe MRI Ventilation After a Single Benralizumab Dose

Chest

McIntosh, M.J. and Kooner, H.K. and Eddy, R.L. and Jeimy, S. and Licskai, C. and Mackenzie, C.A. and Svenningsen, S. and Nair, P. and Yamashita, C. and Parraga, G.

DOI: 10.1016/j.chest.2022.03.003

Disease activity in COPD: time to make imaging biomarkers a PET project?

ERJ Open Research

Stephen Milne and Rachel L. Eddy and Don D. Sin

DOI: 10.1183/23120541.00445-2021

07 / 2021

Editorial for Flow Volume Loop and Regional Ventilation Assessment Using Phase Resolved Functional Lung (PREFUL) MRI: Comparison With 129Xenon Ventilation MRI and Lung Function Testing

Journal of Magnetic Resonance Imaging

Rachel L. Eddy and Jonathan H. Rayment

DOI: 10.1002/jmri.27462

04 / 2021

Measuring Regional Pulmonary Function Using Noncontrast CT: More Reasons to Join the FAN Bandwagon

Radiology

Grace Parraga and Rachel L. Eddy

DOI: 10.1148/radiol.2020203983

01 / 2021

Regional Airway Heterogeneity in Asthma: Histopathology, MRI, and CT Imaging

Chest

Eddy, R.L. and Parraga, G.

DOI: 10.1016/j.chest.2020.09.090

CT Pulmonary Vessels and MRI Ventilation in Chronic Obstructive Pulmonary Disease: Relationship with worsening FEV1 in the TINCan cohort study

Academic Radiology

Barker, A.L. and Eddy, R.L. and MacNeil, J.L. and McCormack, D.G. and Kirby, M. and Parraga, G.

DOI: 10.1016/j.acra.2020.03.006

Bronchial thermoplasty guided by hyperpolarised gas magnetic resonance imaging in adults with severe asthma: A 1-year pilot randomised trial

ERJ Open Research

Svenningsen, S. and Nair, P. and Eddy, R.L. and McIntosh, M.J. and Kjarsgaard, M. and Lim, H.F. and McCormack, D.G. and Cox, G. and Parraga, G.

DOI: 10.1183/23120541.00268-2021

Structure-Function Imaging of Asthma: Airway and Ventilation Biomarkers

Medical Radiology

Barker, A.L. and Eddy, R.L. and Yaremko, H. and Kirby, M. and Parraga, G.

DOI: 10.1007/978-3-030-43539-4_9

Reproducibility of Hyperpolarized 129Xe MRI Ventilation Defect Percent in Severe Asthma to Evaluate Clinical Trial Feasibility

Academic Radiology

Svenningsen, S. and McIntosh, M. and Ouriadov, A. and Matheson, A.M. and Konyer, N.B. and Eddy, R.L. and McCormack, D.G. and Noseworthy, M.D. and Nair, P. and Parraga, G.

DOI: 10.1016/j.acra.2020.04.025

Protocols for multi-site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium

Magnetic Resonance in Medicine

Niedbalski, P.J. and Hall, C.S. and Castro, M. and Eddy, R.L. and Rayment, J.H. and Svenningsen, S. and Parraga, G. and Zanette, B. and Santyr, G.E. and Thomen, R.P. and Stewart, N.J. and Collier, G.J. and Chan, H.-F. and Wild, J.M. and Fain, S.B. and Miller, G.W. and Mata, J.F. and Mugler, J.P. and Driehuys, B. and Willmering, M.M. and Cleveland, Z.I. and Woods, J.C.

DOI: 10.1002/mrm.28985

Computed Tomography Vascular Tree-in-Bud: A Novel Prognostic Imaging Biomarker in COVID-19?

American Journal of Respiratory and Critical Care Medicine

Rachel L. Eddy and Don D. Sin

DOI: 10.1164/rccm.202007-2833ED

09 / 2020

Pulmonary Imaging Phenotypes of Chronic Obstructive Pulmonary Disease Using Multiparametric Response Maps

Radiology

Jonathan L. MacNeil and Dante P. I. Capaldi and Andrew R. Westcott and Rachel L. Eddy and Andrea L. Barker and David G. McCormack and Miranda Kirby and Grace Parraga

DOI: 10.1148/radiol.2020191735

04 / 2020

Is computed tomography airway count related to asthma severity and airway structure and function?

American Journal of Respiratory and Critical Care Medicine

Eddy, R.L. and Svenningsen, S. and Kirby, M. and Knipping, D. and McCormack, D.G. and Licskai, C. and Nair, P. and Parraga, G.

DOI: 10.1164/RCCM.201908-1552OC

Effects of Anti-T2 Biologic Treatment on Lung Ventilation Evaluated by MRI in Adults With Prednisone-Dependent Asthma

Chest

Svenningsen, S. and Eddy, R.L. and Kjarsgaard, M. and Parraga, G. and Nair, P.

DOI: 10.1016/j.chest.2020.04.056

Reply to Miller et al.

American Journal of Respiratory and Critical Care Medicine

Eddy, R.L. and Parraga, G.

DOI: 10.1164/rccm.202005-2034LE

Pulmonary xenon-129 MRI: New opportunities to unravel enigmas in respiratory medicine

European Respiratory Journal

Eddy, R.L. and Parraga, G.

DOI: 10.1183/13993003.01987-2019

Pulmonary Functional MRI and CT in a Survivor of Bronchiolitis and Respiratory Failure Caused by e-Cigarette Use

Chest

Eddy, R.L. and Serajeddini, H. and Knipping, D. and Landman, S.T. and Bosma, K.J. and Mackenzie, C.A. and Dhaliwal, I. and Parraga, G.

DOI: 10.1016/j.chest.2020.06.005

FEV1 and MRI ventilation defect reversibility in asthma and COPD

European Respiratory Journal

Serajeddini, H. and Eddy, R.L. and Licskai, C. and McCormack, D.G. and Parraga, G.

DOI: 10.1183/13993003.01947-2019

Hyperpolarized Helium 3 MRI in Mild-to-Moderate Asthma: Prediction of Postbronchodilator Reversibility

Radiology

Rachel L. Eddy and Sarah Svenningsen and Christopher Licskai and David G. McCormack and Grace Parraga

DOI: 10.1148/radiol.2019190420

10 / 2019

CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma

Chest

Svenningsen, S. and Haider, E. and Boylan, C. and Mukherjee, M. and Eddy, R.L. and Capaldi, D.P.I. and Parraga, G. and Nair, P.

DOI: 10.1016/j.chest.2019.02.403

Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD

Physiological Reports

Eddy, R.L. and Westcott, A. and Maksym, G.N. and Parraga, G. and Dandurand, R.J.

DOI: 10.14814/phy2.13955

MRI and CT lung biomarkers: Towards an in vivo understanding of lung biomechanics

Clinical Biomechanics

Young, H.M. and Eddy, R.L. and Parraga, G.

DOI: 10.1016/j.clinbiomech.2017.09.016

Development and evaluation of pulmonary imaging multi-parametric response maps for deep phenotyping of chronic obstructive pulmonary disease

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

MacNeil, J.L. and Capaldi, D.P.I. and Eddy, R.L. and Westcott, A. and Matheson, A.M. and Barker, A.L. and Ong-Ly, C. and McCormack, D.G. and Parraga, G.

DOI: 10.1117/12.2512849

Nonidentical Twins With Asthma: Spatially Matched CT Airway and MRI Ventilation Abnormalities

Chest

Eddy, R.L. and Matheson, A.M. and Svenningsen, S. and Knipping, D. and Licskai, C. and McCormack, D.G. and Parraga, G.

DOI: 10.1016/j.chest.2019.08.004

Normalisation of MRI ventilation heterogeneity in severe asthma by dupilumab

Thorax

Svenningsen, S. and Haider, E.A. and Eddy, R.L. and Parraga, G. and Nair, P.

DOI: 10.1136/thoraxjnl-2019-213415

Sputum eosinophilia and magnetic resonance imaging ventilation heterogeneity in severe asthma

American Journal of Respiratory and Critical Care Medicine

Svenningsen, S. and Eddy, R.L. and Lim, H.F. and Cox, P.G. and Nair, P. and Parraga, G.

DOI: 10.1164/rccm.201709-1948OC

Free-breathing pulmonary MR imaging to quantify regional ventilation

Radiology

Capaldi, D.P.I. and Eddy, R.L. and Svenningsen, S. and Guo, F. and Baxter, J.S.H. and McLeod, A.J. and Nair, P. and McCormack, D.G. and Parraga, G.

DOI: 10.1148/radiol.2018171993

This is what asthma looks like: Review of new and emerging functional imaging methods and results

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

Eddy, R.L. and Svenningsen, S. and Kassay, A. and McCormack, D.G. and Nair, P. and Parraga, G.

DOI: 10.1080/24745332.2017.1393637

What is the minimal clinically important difference for helium-3 magnetic resonance imaging ventilation defects?

European Respiratory Journal

Eddy, R.L. and Svenningsen, S. and McCormack, D.G. and Parraga, G.

DOI: 10.1183/13993003.00324-2018

Oscillometry and pulmonary MRI measurements of ventilation heterogeneity in obstructive lung disease: Relationship to quality of life and disease control

Journal of Applied Physiology

Young, H.M. and Guo, F. and Eddy, R.L. and Maksym, G. and Parraga, G.

DOI: 10.1152/japplphysiol.01031.2017

MRI ventilation abnormalities predict quality-of-life and lung function changes in mild-tomoderate COPD: Longitudinal TINCan study

Thorax

Kirby, M. and Eddy, R.L. and Pike, D. and Svenningsen, S. and Coxson, H.O. and Sin, D.D. and McCormack, D.G. and Parraga, G.

DOI: 10.1136/thoraxjnl-2016-209770

Ultrashort echo time MRI biomarkers of asthma

Journal of Magnetic Resonance Imaging

Sheikh, K. and Guo, F. and Capaldi, D.P.I. and Ouriadov, A. and Eddy, R.L. and Svenningsen, S. and Parraga, G.

DOI: 10.1002/jmri.25503

Free-breathing Functional Pulmonary MRI: Response to Bronchodilator and Bronchoprovocation in Severe Asthma

Academic Radiology

Capaldi, D.P.I. and Sheikh, K. and Eddy, R.L. and Guo, F. and Svenningsen, S. and Nair, P. and McCormack, D.G. and Parraga, G.

DOI: 10.1016/j.acra.2017.04.012

Regional Heterogeneity of Chronic Obstructive Pulmonary Disease Phenotypes: Pulmonary 3He Magnetic Resonance Imaging and Computed Tomography

Copd Journal of Chronic Obstructive Pulmonary Disease

Pike, D. and Kirby, M. and Eddy, R.L. and Guo, F. and Capaldi, D.P.I. and Ouriadov, A. and McCormack, D.G. and Parraga, G.

DOI: 10.3109/15412555.2015.1123682

Pulmonary MRI in Clinical Trials

Medical Radiology

Capaldi, D.P.I. and Eddy, R.L. and Parraga, G.

DOI: 10.1007/174_2016_81

Anatomical pulmonary magnetic resonance imaging segmentation for regional structure-function measurements of asthma

Medical Physics

Guo, F. and Svenningsen, S. and Eddy, R.L. and Capaldi, D.P.I. and Sheikh, K. and Fenster, A. and Parraga, G.

DOI: 10.1118/1.4948999

Structure-Function Imaging of Cystic Fibrosis Lung Disease

In the current era of highly effective modulator therapies, new tools are required to sensitively quantify lung structural and functional disease changes in people with cystic fibrosis (CF). We are using computed tomography (CT) and magnetic resonance imaging (MRI) tools to deeply characterize lung structure-function in children and adults with CF, evaluate treatment response, and to predict pulmonary exacerbations.

Grants

Co-Principal Investigator. Deep Neural Network for Pulmonary CT to MRI Image Synthesis. Funding Source: UBC Department of Radiology AI Research Grant

Co-Principal Investigator. A Pilot Study to Evaluate Lung Structure-function in Pediatric Survivors of Congenital Diaphragmatic Hernia Using 129Xe MRI. Funding Source: BCCHR Clinical & Translational Seed Grant

Co-Investigator. Working Together: Determining the Cross-Platform Interoperability of Functional Pulmonary MRI. Funding Source: Cystic Fibrosis Foundation Clinical Pilot and Feasibility Award

Honours & Awards

2023 - W.S. Moore Young Investigator Award in Clinical Science Finalist, International Society for Magnetic Resonance in Medicine

2022 - Dr. J Mark Fitzgerald Fellowship Award, Canadian Respiratory Research Network

2022–2023 - Canadian Respiratory Research Network (CRRN) Fellowship Award

2020–2024 - Michael Smith Health Research BC Trainee Award

2020–2022 - Natural Sciences and Engineering Research Council of Canada Postdoctoral Fellowship

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Rachel Eddy

PhD

Investigator, BC Children's Hospital

Academic Affiliations

Contact Information

Location

Publications

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Heterogeneity of short-term elexacaftor-tezacaftor-ivacaftor response in cystic fibrosis using 129Xe MRI

Utility of Hyperpolarized 129-Xenon MRI in Primary Ciliary Dyskinesia

Integration of mass cytometry and single-cell RNA-sequencing of cells in bronchoalveolar lavage

The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: Protocol for a prospective, observational cohort study

A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging

Make it count with photon-counting computed tomography: a revolution in technology for investigating the airways

Transcriptomic profiling of the airway epithelium in COPD links airway eosinophilia to type 2 inflammation and corticosteroid response

Quantification of 129Xe MRI Ventilation-defect-percent Using Binary-threshold, Gaussian Linear-Binning and K-means Methods: Differences in Asthma and COPD

Hyperpolarized129XE MRI and Spectroscopy: Quantitative Measurements, Results, and Emerging Opportunities

Three-Dimensional Free-Breathing Ultrashort Echo Time (UTE) 1H MRI Regional Ventilation: Comparison With Hyperpolarized 129Xe MRI and Pulmonary Function Testing in Healthy Volunteers and People With Cystic Fibrosis

Pulmonary 129Xe MRI: CNN Registration and Segmentation to Generate Ventilation Defect Percent with Multi-center Validation

Following, Seeing, and Understanding: Longitudinal Magnetic Resonance Imaging in Children with Cystic Fibrosis

Loss of Lung Function Led to Loss of Life during the COVID-19 Pandemic

Airway Mucus in Older People Without Chronic Respiratory Illness

Cluster analysis to identify long COVID phenotypes using129Xe magnetic resonance imaging: a multicentre evaluation

129Xe MRI and Oscillometry of Irritant-Induced Asthma After Bronchial Thermoplasty

New physiological measurements in COPD

Single-cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID

A proposed approach to pulmonary long COVID: a viewpoint

Single cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID

Mild airways obstruction: Spirometric diagnostic pitfalls and solutions

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Power Outage: Mitochondrial Dysfunction in Long COVID Measured Using 1H and 31P MR Spectroscopy

Missing airways, ventilation defects and conductive airway physiology in asthma

Pulmonary Vascular Differences in Eosinophilic Asthma after 2.5 Years of Anti"IL-5Ra Treatment

Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis

129Xe MRI Ventilation Defects in Asthma: What is the Upper Limit of Normal and Minimal Clinically Important Difference?

CT Mucus Score and 129Xe MRI Ventilation Defects After 2.5 Years Anti-IL-5Ra in Eosinophilic Asthma

PulmonaryMRIand Cluster Analysis Help Identify Novel Asthma Phenotypes

A Soft Labeling Approach to Develop Automated Algorithms that Incorporate Uncertainty in Pulmonary Opacification on Chest CT using COVID-19 Pneumonia

Pulmonary functional MRI: Detecting the structure"function pathologies that drive asthma symptoms and quality of life

Asthma Control, Airway Mucus, and 129Xe MRI Ventilation After a Single Benralizumab Dose

Disease activity in COPD: time to make imaging biomarkers a PET project?

Editorial for Flow Volume Loop and Regional Ventilation Assessment Using Phase Resolved Functional Lung (PREFUL) MRI: Comparison With 129Xenon Ventilation MRI and Lung Function Testing

Measuring Regional Pulmonary Function Using Noncontrast CT: More Reasons to Join the FAN Bandwagon

Regional Airway Heterogeneity in Asthma: Histopathology, MRI, and CT Imaging

CT Pulmonary Vessels and MRI Ventilation in Chronic Obstructive Pulmonary Disease: Relationship with worsening FEV1 in the TINCan cohort study

Bronchial thermoplasty guided by hyperpolarised gas magnetic resonance imaging in adults with severe asthma: A 1-year pilot randomised trial

Structure-Function Imaging of Asthma: Airway and Ventilation Biomarkers

Reproducibility of Hyperpolarized 129Xe MRI Ventilation Defect Percent in Severe Asthma to Evaluate Clinical Trial Feasibility

Protocols for multi-site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium

Computed Tomography Vascular Tree-in-Bud: A Novel Prognostic Imaging Biomarker in COVID-19?

Pulmonary Imaging Phenotypes of Chronic Obstructive Pulmonary Disease Using Multiparametric Response Maps

Is computed tomography airway count related to asthma severity and airway structure and function?

Effects of Anti-T2 Biologic Treatment on Lung Ventilation Evaluated by MRI in Adults With Prednisone-Dependent Asthma

Reply to Miller et al.

Pulmonary xenon-129 MRI: New opportunities to unravel enigmas in respiratory medicine

Pulmonary Functional MRI and CT in a Survivor of Bronchiolitis and Respiratory Failure Caused by e-Cigarette Use

FEV1 and MRI ventilation defect reversibility in asthma and COPD

Hyperpolarized Helium 3 MRI in Mild-to-Moderate Asthma: Prediction of Postbronchodilator Reversibility

CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma

Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD

MRI and CT lung biomarkers: Towards an in vivo understanding of lung biomechanics

Development and evaluation of pulmonary imaging multi-parametric response maps for deep phenotyping of chronic obstructive pulmonary disease

Nonidentical Twins With Asthma: Spatially Matched CT Airway and MRI Ventilation Abnormalities

Normalisation of MRI ventilation heterogeneity in severe asthma by dupilumab

Sputum eosinophilia and magnetic resonance imaging ventilation heterogeneity in severe asthma

Free-breathing pulmonary MR imaging to quantify regional ventilation

This is what asthma looks like: Review of new and emerging functional imaging methods and results

What is the minimal clinically important difference for helium-3 magnetic resonance imaging ventilation defects?

Oscillometry and pulmonary MRI measurements of ventilation heterogeneity in obstructive lung disease: Relationship to quality of life and disease control

MRI ventilation abnormalities predict quality-of-life and lung function changes in mild-tomoderate COPD: Longitudinal TINCan study

Ultrashort echo time MRI biomarkers of asthma

Free-breathing Functional Pulmonary MRI: Response to Bronchodilator and Bronchoprovocation in Severe Asthma

Regional Heterogeneity of Chronic Obstructive Pulmonary Disease Phenotypes: Pulmonary 3He Magnetic Resonance Imaging and Computed Tomography

Pulmonary MRI in Clinical Trials

Anatomical pulmonary magnetic resonance imaging segmentation for regional structure-function measurements of asthma

Research

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Structure-Function Imaging of Cystic Fibrosis Lung Disease