- Overview
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The focus of my research is to better understand lung disease, and potential risks for lung disease, in children that can then be used to better treat patients and potentially stop lung disease from developing or advancing. To do this, we develop and apply new non-invasive medical imaging tools to deeply measure lung structure and function. We primarily use magnetic resonance imaging (MRI), which allows us to safely scan people multiple times and measure unique aspects of lung function that are not possible using any other clinical or imaging tool.
- Publications
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Transcriptomic profiling of the airway epithelium in COPD links airway eosinophilia to type 2 inflammation and corticosteroid response
European Respiratory Journal
Clarus Leung and Hye Yun Park and Xuan Li and Graeme J. Koelwyn and Josie Tuong and Seyed Milad Vahedi and Fernando Sergio Leitao Filho and Julia S. Yang and Rachel L. Eddy and Stephen Milne and Min Hyung Ryu and Hiroto Takiguchi and Kentaro Akata and Seung Won Ra and Ji-Yong Moon and Hyun Kuk Kim and Yuji Cho and Kei Yamasaki and Stephan F. van Eeden and Tawimas Shaipanich and Stephen Lam and Janice M. Leung and Don D. Sin
DOI: 10.1183/13993003.01875-2024
05/2025Make it count with photon-counting computed tomography: a revolution in technology for investigating the airways
European Respiratory Journal
Rachel L. Eddy and Don D. Sin
DOI: 10.1183/13993003.00297-2025
04/2025Power Outage: Mitochondrial Dysfunction in Long COVID Measured Using 1H and 31P MR Spectroscopy
Radiology
Grace Parraga and Rachel L. Eddy
DOI: 10.1148/radiol.242833
12/2024Airway Mucus in Older People Without Chronic Respiratory Illness
CHEST
Harkiran K. Kooner and Hana Serajeddini and Rachel L. Eddy and Cory Yamashita and Sarah Svenningsen and Grace Parraga
DOI: 10.1016/j.chest.2024.04.023
09/2024Cluster analysis to identify long COVID phenotypes using129Xe magnetic resonance imaging: a multicentre evaluation
European Respiratory Journal
Rachel L. Eddy and David Mummy and Shuo Zhang and Haoran Dai and Aryil Bechtel and Alexandra Schmidt and Bradie Frizzell and Firoozeh V. Gerayeli and Jonathon A. Leipsic and Janice M. Leung and Bastiaan Driehuys and Loretta G. Que and Mario Castro and Don D. Sin and Peter J. Niedbalski
DOI: 10.1183/13993003.02301-2023
03/2024129Xe MRI and Oscillometry of Irritant-Induced Asthma After Bronchial Thermoplasty
CHEST
Marrissa J. McIntosh and Joseph J. Hofmann and Harkiran K. Kooner and Rachel L. Eddy and Grace Parraga and Constance A. Mackenzie
DOI: 10.1016/j.chest.2023.09.010
02/2024New physiological measurements in COPD
ERS Monograph
Milne, S. and Tonga, K.O. and Eddy, R.L. and Thompson, B.R. and Thamrin, C. and King, G.G.
DOI: 10.1183/2312508X.10006923
2024A proposed approach to pulmonary long COVID: a viewpoint
European Respiratory Journal
Gerayeli, F.V. and Eddy, R.L. and Sin, D.D.
DOI: 10.1183/13993003.02302-2023
2024Single cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID
medRxiv
Gerayeli, F.V. and Park, H.Y. and Milne, S. and Li, X. and Yang, C.X. and Tuong, J. and Eddy, R.L. and Guinto, E. and Cheung, C.Y. and Yang, J.S.W. and Gilchrist, C. and Abbas, D. and Stach, T. and Leung, C. and Shaipanich, T. and Leipsic, J. and Koelwyn, G. and Leung, J.M. and Sin, D.D.
DOI: 10.1101/2024.02.26.24302674
2024Mild airways obstruction: Spirometric diagnostic pitfalls and solutions
Current Opinion in Pulmonary Medicine
Alotaibi, N.M. and Eddy, R.L. and Sin, D.D.
DOI: 10.1097/MCP.0000000000001023
2024Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Journal of Visualized Experiments
Eddy, R.L. and Xu, G.H. and Leipsic, J.A. and Leung, J.M. and Sin, D.D. and Hall, C.S. and Tam, R.C.
DOI: 10.3791/66257
2024Missing airways, ventilation defects and conductive airway physiology in asthma
The European respiratory journal
Verbanck, S. and Eddy, R.L. and McIntosh, M.J. and Parraga, G. and Foy, B.H.
DOI: 10.1183/13993003.00242-2024
2024Pulmonary Vascular Differences in Eosinophilic Asthma after 2.5 Years of Anti–IL-5Ra Treatment
American Journal of Respiratory and Critical Care Medicine
McIntosh, M.J. and Matheson, A.M. and Kooner, H.K. and Eddy, R.L. and Serajeddini, H. and Yamashita, C. and Parraga, G.
DOI: 10.1164/rccm.202305-0849LE
2023Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis
European Respiratory Review
Guinto, E. and Gerayeli, F.V. and Eddy, R.L. and Lee, H. and Milne, S. and Sin, D.D.
DOI: 10.1183/16000617.0253-2022
2023129Xe MRI Ventilation Defects in Asthma: What is the Upper Limit of Normal and Minimal Clinically Important Difference?
Academic Radiology
McIntosh, M.J. and Biancaniello, A. and Kooner, H.K. and Bhalla, A. and Serajeddini, H. and Yamashita, C. and Parraga, G. and Eddy, R.L.
DOI: 10.1016/j.acra.2023.03.010
2023CT Mucus Score and 129Xe MRI Ventilation Defects After 2.5 Years’ Anti-IL-5Ra in Eosinophilic Asthma
Chest
McIntosh, M.J. and Kooner, H.K. and Eddy, R.L. and Wilson, A. and Serajeddini, H. and Bhalla, A. and Licskai, C. and Mackenzie, C.A. and Yamashita, C. and Parraga, G.
DOI: 10.1016/j.chest.2023.02.009
2023PulmonaryMRIand Cluster Analysis Help Identify Novel Asthma Phenotypes
Journal of Magnetic Resonance Imaging
Rachel L. Eddy and Marrissa J. McIntosh and Alexander M. Matheson and David G. McCormack and Christopher Licskai and Grace Parraga
DOI: 10.1002/jmri.28152
11/2022A Soft Labeling Approach to Develop Automated Algorithms that Incorporate Uncertainty in Pulmonary Opacification on Chest CT using COVID-19 Pneumonia
Academic Radiology
Keegan Lensink and Fu (Jorden) Lo and Rachel L. Eddy and Marco Law and Issam Laradji and Eldad Haber and Savvas Nicolaou and Darra Murphy and William A. Parker
DOI: 10.1016/j.acra.2022.03.025
07/2022Pulmonary functional MRI: Detecting the structure–function pathologies that drive asthma symptoms and quality of life
Respirology
Kooner, H.K. and McIntosh, M.J. and Desaigoudar, V. and Rayment, J.H. and Eddy, R.L. and Driehuys, B. and Parraga, G.
DOI: 10.1111/resp.14197
2022Asthma Control, Airway Mucus, and 129Xe MRI Ventilation After a Single Benralizumab Dose
Chest
McIntosh, M.J. and Kooner, H.K. and Eddy, R.L. and Jeimy, S. and Licskai, C. and Mackenzie, C.A. and Svenningsen, S. and Nair, P. and Yamashita, C. and Parraga, G.
DOI: 10.1016/j.chest.2022.03.003
2022Disease activity in COPD: time to make imaging biomarkers a PET project?
ERJ Open Research
Stephen Milne and Rachel L. Eddy and Don D. Sin
DOI: 10.1183/23120541.00445-2021
07/2021Editorial for “Flow Volume Loop and Regional Ventilation Assessment Using Phase Resolved Functional Lung (PREFUL) MRI: Comparison With 129Xenon Ventilation MRI and Lung Function Testing”
Journal of Magnetic Resonance Imaging
Rachel L. Eddy and Jonathan H. Rayment
DOI: 10.1002/jmri.27462
04/2021Measuring Regional Pulmonary Function Using Noncontrast CT: More Reasons to Join the FAN Bandwagon
Radiology
Grace Parraga and Rachel L. Eddy
DOI: 10.1148/radiol.2020203983
01/2021Regional Airway Heterogeneity in Asthma: Histopathology, MRI, and CT Imaging
Chest
Eddy, R.L. and Parraga, G.
DOI: 10.1016/j.chest.2020.09.090
2021CT Pulmonary Vessels and MRI Ventilation in Chronic Obstructive Pulmonary Disease: Relationship with worsening FEV1 in the TINCan cohort study
Academic Radiology
Barker, A.L. and Eddy, R.L. and MacNeil, J.L. and McCormack, D.G. and Kirby, M. and Parraga, G.
DOI: 10.1016/j.acra.2020.03.006
2021Bronchial thermoplasty guided by hyperpolarised gas magnetic resonance imaging in adults with severe asthma: A 1-year pilot randomised trial
ERJ Open Research
Svenningsen, S. and Nair, P. and Eddy, R.L. and McIntosh, M.J. and Kjarsgaard, M. and Lim, H.F. and McCormack, D.G. and Cox, G. and Parraga, G.
DOI: 10.1183/23120541.00268-2021
2021Structure-Function Imaging of Asthma: Airway and Ventilation Biomarkers
Medical Radiology
Barker, A.L. and Eddy, R.L. and Yaremko, H. and Kirby, M. and Parraga, G.
DOI: 10.1007/978-3-030-43539-4_9
2021Reproducibility of Hyperpolarized 129Xe MRI Ventilation Defect Percent in Severe Asthma to Evaluate Clinical Trial Feasibility
Academic Radiology
Svenningsen, S. and McIntosh, M. and Ouriadov, A. and Matheson, A.M. and Konyer, N.B. and Eddy, R.L. and McCormack, D.G. and Noseworthy, M.D. and Nair, P. and Parraga, G.
DOI: 10.1016/j.acra.2020.04.025
2021Protocols for multi-site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium
Magnetic Resonance in Medicine
Niedbalski, P.J. and Hall, C.S. and Castro, M. and Eddy, R.L. and Rayment, J.H. and Svenningsen, S. and Parraga, G. and Zanette, B. and Santyr, G.E. and Thomen, R.P. and Stewart, N.J. and Collier, G.J. and Chan, H.-F. and Wild, J.M. and Fain, S.B. and Miller, G.W. and Mata, J.F. and Mugler, J.P. and Driehuys, B. and Willmering, M.M. and Cleveland, Z.I. and Woods, J.C.
DOI: 10.1002/mrm.28985
2021Computed Tomography Vascular Tree-in-Bud: A Novel Prognostic Imaging Biomarker in COVID-19?
American Journal of Respiratory and Critical Care Medicine
Rachel L. Eddy and Don D. Sin
DOI: 10.1164/rccm.202007-2833ED
09/2020Pulmonary Imaging Phenotypes of Chronic Obstructive Pulmonary Disease Using Multiparametric Response Maps
Radiology
Jonathan L. MacNeil and Dante P. I. Capaldi and Andrew R. Westcott and Rachel L. Eddy and Andrea L. Barker and David G. McCormack and Miranda Kirby and Grace Parraga
DOI: 10.1148/radiol.2020191735
04/2020Is computed tomography airway count related to asthma severity and airway structure and function?
American Journal of Respiratory and Critical Care Medicine
Eddy, R.L. and Svenningsen, S. and Kirby, M. and Knipping, D. and McCormack, D.G. and Licskai, C. and Nair, P. and Parraga, G.
DOI: 10.1164/RCCM.201908-1552OC
2020Effects of Anti-T2 Biologic Treatment on Lung Ventilation Evaluated by MRI in Adults With Prednisone-Dependent Asthma
Chest
Svenningsen, S. and Eddy, R.L. and Kjarsgaard, M. and Parraga, G. and Nair, P.
DOI: 10.1016/j.chest.2020.04.056
2020Reply to Miller et al.
American Journal of Respiratory and Critical Care Medicine
Eddy, R.L. and Parraga, G.
DOI: 10.1164/rccm.202005-2034LE
2020Pulmonary xenon-129 MRI: New opportunities to unravel enigmas in respiratory medicine
European Respiratory Journal
Eddy, R.L. and Parraga, G.
DOI: 10.1183/13993003.01987-2019
2020Pulmonary Functional MRI and CT in a Survivor of Bronchiolitis and Respiratory Failure Caused by e-Cigarette Use
Chest
Eddy, R.L. and Serajeddini, H. and Knipping, D. and Landman, S.T. and Bosma, K.J. and Mackenzie, C.A. and Dhaliwal, I. and Parraga, G.
DOI: 10.1016/j.chest.2020.06.005
2020FEV1 and MRI ventilation defect reversibility in asthma and COPD
European Respiratory Journal
Serajeddini, H. and Eddy, R.L. and Licskai, C. and McCormack, D.G. and Parraga, G.
DOI: 10.1183/13993003.01947-2019
2020Hyperpolarized Helium 3 MRI in Mild-to-Moderate Asthma: Prediction of Postbronchodilator Reversibility
Radiology
Rachel L. Eddy and Sarah Svenningsen and Christopher Licskai and David G. McCormack and Grace Parraga
DOI: 10.1148/radiol.2019190420
10/2019CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma
Chest
Svenningsen, S. and Haider, E. and Boylan, C. and Mukherjee, M. and Eddy, R.L. and Capaldi, D.P.I. and Parraga, G. and Nair, P.
DOI: 10.1016/j.chest.2019.02.403
2019Oscillometry and pulmonary magnetic resonance imaging in asthma and COPD
Physiological Reports
Eddy, R.L. and Westcott, A. and Maksym, G.N. and Parraga, G. and Dandurand, R.J.
DOI: 10.14814/phy2.13955
2019MRI and CT lung biomarkers: Towards an in vivo understanding of lung biomechanics
Clinical Biomechanics
Young, H.M. and Eddy, R.L. and Parraga, G.
DOI: 10.1016/j.clinbiomech.2017.09.016
2019Development and evaluation of pulmonary imaging multi-parametric response maps for deep phenotyping of chronic obstructive pulmonary disease
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
MacNeil, J.L. and Capaldi, D.P.I. and Eddy, R.L. and Westcott, A. and Matheson, A.M. and Barker, A.L. and Ong-Ly, C. and McCormack, D.G. and Parraga, G.
DOI: 10.1117/12.2512849
2019Nonidentical Twins With Asthma: Spatially Matched CT Airway and MRI Ventilation Abnormalities
Chest
Eddy, R.L. and Matheson, A.M. and Svenningsen, S. and Knipping, D. and Licskai, C. and McCormack, D.G. and Parraga, G.
DOI: 10.1016/j.chest.2019.08.004
2019Normalisation of MRI ventilation heterogeneity in severe asthma by dupilumab
Thorax
Svenningsen, S. and Haider, E.A. and Eddy, R.L. and Parraga, G. and Nair, P.
DOI: 10.1136/thoraxjnl-2019-213415
2019Sputum eosinophilia and magnetic resonance imaging ventilation heterogeneity in severe asthma
American Journal of Respiratory and Critical Care Medicine
Svenningsen, S. and Eddy, R.L. and Lim, H.F. and Cox, P.G. and Nair, P. and Parraga, G.
DOI: 10.1164/rccm.201709-1948OC
2018Free-breathing pulmonary MR imaging to quantify regional ventilation
Radiology
Capaldi, D.P.I. and Eddy, R.L. and Svenningsen, S. and Guo, F. and Baxter, J.S.H. and McLeod, A.J. and Nair, P. and McCormack, D.G. and Parraga, G.
DOI: 10.1148/radiol.2018171993
2018This is what asthma looks like: Review of new and emerging functional imaging methods and results
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Eddy, R.L. and Svenningsen, S. and Kassay, A. and McCormack, D.G. and Nair, P. and Parraga, G.
DOI: 10.1080/24745332.2017.1393637
2018What is the minimal clinically important difference for helium-3 magnetic resonance imaging ventilation defects?
European Respiratory Journal
Eddy, R.L. and Svenningsen, S. and McCormack, D.G. and Parraga, G.
DOI: 10.1183/13993003.00324-2018
2018Oscillometry and pulmonary MRI measurements of ventilation heterogeneity in obstructive lung disease: Relationship to quality of life and disease control
Journal of Applied Physiology
Young, H.M. and Guo, F. and Eddy, R.L. and Maksym, G. and Parraga, G.
DOI: 10.1152/japplphysiol.01031.2017
2018MRI ventilation abnormalities predict quality-of-life and lung function changes in mild-tomoderate COPD: Longitudinal TINCan study
Thorax
Kirby, M. and Eddy, R.L. and Pike, D. and Svenningsen, S. and Coxson, H.O. and Sin, D.D. and McCormack, D.G. and Parraga, G.
DOI: 10.1136/thoraxjnl-2016-209770
2017Ultrashort echo time MRI biomarkers of asthma
Journal of Magnetic Resonance Imaging
Sheikh, K. and Guo, F. and Capaldi, D.P.I. and Ouriadov, A. and Eddy, R.L. and Svenningsen, S. and Parraga, G.
DOI: 10.1002/jmri.25503
2017Free-breathing Functional Pulmonary MRI: Response to Bronchodilator and Bronchoprovocation in Severe Asthma
Academic Radiology
Capaldi, D.P.I. and Sheikh, K. and Eddy, R.L. and Guo, F. and Svenningsen, S. and Nair, P. and McCormack, D.G. and Parraga, G.
DOI: 10.1016/j.acra.2017.04.012
2017Regional Heterogeneity of Chronic Obstructive Pulmonary Disease Phenotypes: Pulmonary 3He Magnetic Resonance Imaging and Computed Tomography
COPD: Journal of Chronic Obstructive Pulmonary Disease
Pike, D. and Kirby, M. and Eddy, R.L. and Guo, F. and Capaldi, D.P.I. and Ouriadov, A. and McCormack, D.G. and Parraga, G.
DOI: 10.3109/15412555.2015.1123682
2016Pulmonary MRI in Clinical Trials
Medical Radiology
Capaldi, D.P.I. and Eddy, R.L. and Parraga, G.
DOI: 10.1007/174_2016_81
2016Anatomical pulmonary magnetic resonance imaging segmentation for regional structure-function measurements of asthma
Medical Physics
Guo, F. and Svenningsen, S. and Eddy, R.L. and Capaldi, D.P.I. and Sheikh, K. and Fenster, A. and Parraga, G.
DOI: 10.1118/1.4948999
2016 - Research
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Structure-Function Imaging of Cystic Fibrosis Lung Disease
In the current era of highly effective modulator therapies, new tools are required to sensitively quantify lung structural and functional disease changes in people with cystic fibrosis (CF). We are using computed tomography (CT) and magnetic resonance imaging (MRI) tools to deeply characterize lung structure-function in children and adults with CF, evaluate treatment response, and to predict pulmonary exacerbations.GrantsCo-Principal Investigator. Deep Neural Network for Pulmonary CT to MRI Image Synthesis. Funding Source: UBC Department of Radiology AI Research Grant
Co-Principal Investigator. A Pilot Study to Evaluate Lung Structure-function in Pediatric Survivors of Congenital Diaphragmatic Hernia Using 129Xe MRI. Funding Source: BCCHR Clinical & Translational Seed Grant
Co-Investigator. Working Together: Determining the Cross-Platform Interoperability of Functional Pulmonary MRI. Funding Source: Cystic Fibrosis Foundation Clinical Pilot and Feasibility Award
Honours & Awards2023 - W.S. Moore Young Investigator Award in Clinical Science Finalist, International Society for Magnetic Resonance in Medicine
2022 - Dr. J Mark Fitzgerald Fellowship Award, Canadian Respiratory Research Network
2022–2023 - Canadian Respiratory Research Network (CRRN) Fellowship Award
2020–2024 - Michael Smith Health Research BC Trainee Award
2020–2022 - Natural Sciences and Engineering Research Council of Canada Postdoctoral Fellowship
Research Group MembersKimia Rostin, Medical Student - FLEX
Digestive ‘treasure chest’ shows promise for targeted drug treatment in the gut
BCCHR and UBC researchers have designed a new approach to drug delivery called ‘GlycoCaging’ that transports medicine for inflammatory bowel disease directly to the gut.
