Dawn Gano

MD, FRCPC, MAS

Investigator and Pediatric Neurologist, BC Children's Hospital
Head, Division of Neurology, Department of Pediatrics, University of British Columbia

The central goal of my work is the promotion of brain health across the lifecycle through a specific focus on fetal and newborn brain health. Our lab aims to further an understanding of the causes and outcomes of neurological conditions that present prenatally, identify modifiable predictors of brain injuries across the perinatal age spectrum spanning the 20th week of gestation through the first month of age, and ultimately, develop and evaluate novel strategies to improve long-term neurological outcomes. Our work evolves from family and community stakeholder engagement and interdisciplinary collaboration.

Academic Affiliations

  • Professor, Division of Neurology, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Brain, Behaviour & Development
  • Research Group(s): Clinical Practice, Outcomes and Innovation; Neurodevelopmental and Neurological Disorders; Origins of Child Health and Disease; Rare Diseases; Visualizing the Brain

Contact Information

Location

4480 Oak Street, Vancouver, British Columbia, Canada, V6H 3V4

Prediction of CSF Intervention in Fetal Ventriculomegaly via Artificial Intelligence"Powered Normative Modeling

American Journal of Neuroradiology

Minerva Zhou and Siddharthasiva Anbu Rajan and Pierre Nedelec and Juana Barrera Bayona and Orit Glenn and Nalin Gupta and Dawn Gano and Elizabeth George and Andreas M. Rauschecker

DOI: 10.3174/ajnr.A9000

03 / 2026

Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience

Annals of the Child Neurology Society

William D. Graf and Timothy M. Crombleholme and Leon G. Epstein and Dawn Gano and Phillip L. Pearl and Timothy V. Salomons and Mark S. Scher and Elise Turk and Klaus-Peter Zimmer and Harvey B. Sarnat

DOI: 10.1002/cns3.70057

03 / 2026

Neonatal neurocritical care considerations for prenatally identified neurological disorders

Pediatric Research

Dawn Gano and James P. Boardman and Sonika Agarwal and Charu Venkatesan and Tomo Tarui and Vann Chau and Courtney J. Wusthoff and Monica E. Lemmon and Barbara Scelsa and Brigitte Vollmer and Sarah B. Mulkey and Mark S. Scher and Anthony R. Hart and Eric S. Peeples and Firdose Nakwa and Eleanor Molloy and Andrea C. Pardo and Eleanor Molloy and Eric S. Peeples and Kaashif A. Ahmad and Hany Aly and James P. Boardman and Vann Chau and Gabrielle deVeber and Dawn Gano and Emily M. Herzberg and Lara Leijser and Thiviya Selvanathan and Latha Srinivasan and Courtney J. Wusthoff

DOI: 10.1038/s41390-025-04691-w

01 / 2026

In utero precision medicine for severe, early-onset neurogenetic disease: scientific, clinical and ethical considerations

Pediatric Research

Beltran Borges and Julia E. H. Brown and Dawn Gano

DOI: 10.1038/s41390-025-04487-y

12 / 2025

Evidence versus equipoise in late preterm neonates with encephalopathy; to cool or not to cool, that is the question!

Pediatric Research

Julia K. Charlton and Thiviya Selvanathan and Dawn Gano

DOI: 10.1038/s41390-025-04626-5

11 / 2025

Cumulative caffeine exposure predicts neurodevelopmental outcomes in premature infants.

Pediatric research

Ostrem BEL and Odell E and Grelli KN and Kramer K and Chan N and Jiang F and Xu D and Barkovich AJ and Barkovich MJ and Ferriero DM and Gano D

DOI: 10.1038/s41390-025-04387-1 PubMed: 40975732

09 / 2025

Communicating neurological prognosis in the prenatal period: a narrative review and practice guidelines

Pediatric Research

Field, N.K. and Venkatesan, C. and Gano, D. and Agarwal, S. and Young, K.A. and Wheeler, S. and Russ, J.B. and Lemmon, M.E.

DOI: 10.1038/s41390-025-03805-8

Prenatally Diagnosed Holoprosencephaly: Review of the Literature and Practical Recommendations for Pediatric Neurologists

Pediatric Neurology

Scelsa, B. and Gano, D. and Hart, A.R. and Vollmer, B. and Lemmon, M.E. and Tarui, T. and Mulkey, S.B. and Scher, M. and Pardo, A.C. and Agarwal, S. and Venkatesan, C.

DOI: 10.1016/j.pediatrneurol.2024.10.014

Difficult Conversations in Fetal-Neonatal Neurology: National Survey of Educational Experiences and Needs of Child Neurology Residents

Pediatric Neurology

Bach, A.M. and Gano, D. and Venkatesan, C. and Lemmon, M.E. and Agarwal, S.

DOI: 10.1016/j.pediatrneurol.2025.03.014

Fetal Intracranial Hemorrhage due to Uniparental Disomy and Unmasked MPL-Related Congenital Amegakaryocytic Thrombocytopenia

Prenatal Diagnosis

Gano, D. and Glenn, O.A. and Rand, L. and Heraty, K. and Devine, P. and Norton, M.E. and Sparks, T.N.

DOI: 10.1002/pd.6737

Fetal Callosal Anomalies: A Narrative Review and Practical Recommendations for Pediatric Neurologists

Pediatric Neurology

Pardo, A.C. and Agarwal, S. and Vollmer, B. and Venkatesan, C. and Scelsa, B. and Lemmon, M.E. and Mulkey, S.B. and Scher, M. and Hart, A.R. and Gano, D. and Tarui, T.

DOI: 10.1016/j.pediatrneurol.2025.01.022

Advocating for child health through storytelling

Pediatric Research

Gano, D.

DOI: 10.1038/s41390-025-04198-4

Data Collection Variability Across Neonatal Hypoxic-Ischemic Encephalopathy Registries

The Journal of Pediatrics

DOI: 10.1016/J.JPEDS.2025.114476

Correction: Communicating neurological prognosis in the prenatal period: a narrative review and practice guidelines (Pediatric Research, (2025), 10.1038/s41390-025-03805-8)

Pediatric Research

Field, N.K. and Venkatesan, C. and Gano, D. and Agarwal, S. and Young, K.A. and Wheeler, S. and Russ, J.B. and Lemmon, M.E.

DOI: 10.1038/s41390-025-04316-2

Punctate white matter lesions predict risk for cerebral palsy: further evidence for routine brain MRI in preterm infants

Pediatric Research

Selvanathan, T. and Gano, D.

DOI: 10.1038/s41390-025-04333-1

Prenatally Diagnosed Absent Septum Pellucidum and Septo-Optic Dysplasia: A Narrative Review and Practical Recommendations for Pediatric Neurologists

Pediatric Neurology

Venkatesan, C. and Gano, D. and Scelsa, B. and Vollmer, B. and Lemmon, M.E. and Pardo, A.C. and Mulkey, S.B. and Tarui, T. and Scher, M. and Hart, A.R. and Agarwal, S.

DOI: 10.1016/j.pediatrneurol.2024.12.014

Fetal intracerebral hemorrhage: review of the literature and practice considerations

Pediatric Research

Dunbar, M. and Agarwal, S. and Venkatesan, C. and Vollmer, B. and Scelsa, B. and Pardo, A.C. and Tarui, T. and Hart, A.R. and Mulkey, S.B. and Lemmon, M.E. and Gano, D.

DOI: 10.1038/s41390-025-04000-5

A practice survey of prenatally identified supratentorial midline brain malformations

Annals of Neurology

Two sides of the same coin: distinguishing the role of fetal versus maternal placental pathology on brain injury of prematurity

Pediatric Research

Russ, J.B. and Gano, D.

DOI: 10.1038/s41390-025-04299-0

Pediatric Neurology Trainee Award

Pediatric Neurology

Beslow, L.A. and Gano, D. and DiMario, F.J. and J{\'o}?wiak, S. and Sivaswamy, L. and Kothare, S.V. and Ghosh, P.S. and Torres, A.R. and Wu, Y. and Santoro, J.D.

DOI: 10.1016/j.pediatrneurol.2025.05.001

Maternal Social Determinants of Health and Risk of Perinatal Hypoxic-Ischemic Encephalopathy

JAMA Neurology

Gano, D. and Kuzniewicz, M.W. and Montoya-Williams, D. and Scheffler, A. and Fuentes-Afflick, E. and Wu, Y.W. and Cornet, M.-C.

DOI: 10.1001/jamaneurol.2025.1659

Fetal malformations of cortical development: review and clinical guidance

Brain

Russ, J.B. and Agarwal, S. and Venkatesan, C. and Scelsa, B. and Vollmer, B. and Tarui, T. and Pardo, A.C. and Lemmon, M.E. and Mulkey, S.B. and Hart, A.R. and Nagaraj, U.D. and Kuller, J.A. and Whitehead, M.T. and Cohen, J.L. and Gebb, J.S. and Glenn, O.A. and Norton, M.E. and Gano, D.

DOI: 10.1093/brain/awaf094

Predicting preterm post-hemorrhagic ventricular dilatation and the need for biomarkers

Pediatric Research

Gano, D. and de Vries, L.S.

DOI: 10.1038/s41390-024-03468-x

Novel Approaches to the Treatment of Preterm White Matter Injury through Targeting Remyelination

Clinics in Perinatology

Ostrem, B.E.L. and Gano, D.

DOI: 10.1016/j.clp.2025.02.005

Fetal MRI Findings, Etiology, and Outcome in Prenatally Diagnosed Schizencephaly

American Journal of Neuroradiology

George, E. and Vassar, R. and Yu, Y. and Norton, M.E. and Gano, D. and Glenn, O.A.

DOI: 10.3174/ajnr.A8523

Diverse childhood neurologic disorders and outcomes following fetal neurologic consultation

Seminars in Fetal and Neonatal Medicine

Gano, D. and Pardo, A.C. and Glenn, O.A. and Sherr, E.

DOI: 10.1016/j.siny.2024.101524

Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series)

Pediatric Research

Molloy, E.J. and El-Dib, M. and Soul, J. and Juul, S. and Gunn, A.J. and Bender, M. and Gonzalez, F. and Bearer, C. and Wu, Y. and Robertson, N.J. and Cotton, M. and Branagan, A. and Hurley, T. and Tan, S. and Laptook, A. and Austin, T. and Mohammad, K. and Rogers, E. and Luyt, K. and Wintermark, P. and Bonifacio, S.L. and Aly, H. and Chau, V. and Glass, H. and Lemmon, M. and Wusthoff, C. and deVeber, G. and Pardo, A. and Carrasco, M. and Boardman, J. and Gano, D. and Peeples, E.

DOI: 10.1038/s41390-023-02895-6

Families as partners in neonatal neuro-critical care programs

Pediatric Research

Bansal, S. and Molloy, E.J. and Rogers, E. and Bidegain, M. and Pilon, B. and Hurley, T. and Lemmon, M.E. and Selvanathan, T. and Nakwa, F. and Leijser, L. and Wusthoff, C. and Peeples, E. and Pardo, A. and Glass, H. and Gano, D. and deVeber, G. and Chau, V. and McCaul, M.C. and Boardman, J. and Aly, H. and Wintermark, P. and Bonifacio, S.

DOI: 10.1038/s41390-024-03257-6

Brain age predicted using graph convolutional neural network explains neurodevelopmental trajectory in preterm neonates

European Radiology

Liu, M. and Lu, M. and Kim, S.Y. and Lee, H.J. and Duffy, B.A. and Yuan, S. and Chai, Y. and Cole, J.H. and Wu, X. and Toga, A.W. and Jahanshad, N. and Gano, D. and Barkovich, A.J. and Xu, D. and Kim, H.

DOI: 10.1007/s00330-023-10414-8

Neuromonitoring practices for neonates with congenital heart disease: a scoping review

Pediatric Research

Pardo, A.C. and Carrasco, M. and Wintermark, P. and Nunes, D. and Chock, V.Y. and Sen, S. and Wusthoff, C.J. and Bonifacio, S. and Aly, H. and Chau, V. and Glass, H. and Lemmon, M. and deVeber, G. and Boardman, J.P. and Gano, D. and Peeples, E. and Leijser, L.M. and Nakwa, F. and Selvanathan, T.

DOI: 10.1038/s41390-024-03484-x

Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after blood"brain barrier disruption

Proceedings of the National Academy of Sciences of the United States of America

Weaver, O. and Gano, D. and Zhou, Y. and Kim, H. and Tognatta, R. and Yan, Z. and Ryu, J.K. and Brandt, C. and Basu, T. and Grana, M. and Cabriga, B. and Alzamora, M.D.P.S. and James Barkovich, A. and Akassoglou, K. and Petersen, M.A.

DOI: 10.1073/pnas.2323050121

Trends in prenatal and pediatric viral infections, and the impact of climate change

Pediatric Research

Gano, D. and Bearer, C.F.

DOI: 10.1038/s41390-023-02986-4

Fetal stroke- etiopathogenesis affecting the maternal-placental-fetal triad and neonate

Seminars in Fetal and Neonatal Medicine

Vernon, L.E. and Gano, D. and Pardo, A.C.

DOI: 10.1016/j.siny.2024.101527

Cerebrovascular Injury From Early-Onset Neonatal Escherichia coli Meningitis: Expanding the Clinical-Radiologic Phenotype

Pediatric Neurology

Garc{\'i}a, F.G. and Li, Y. and Vassar, R. and Hawkins, C. and Petersen, M. and Gano, D.

DOI: 10.1016/j.pediatrneurol.2024.09.020

Fetal Intraparenchymal Hemorrhage Imaging Patterns, Etiology, and Outcomes: A Single Center Cohort Study

Annals of Neurology

Vassar, R. and George, E. and Mogga, A. and Li, Y. and Norton, M.E. and Glenn, O. and Gano, D.

DOI: 10.1002/ana.27072

Brain health equity and the influence of social determinants across the life cycle

Seminars in Fetal and Neonatal Medicine

Bach, A.M. and Peeler, M. and Caunca, M. and Olusanya, B.O. and Rosendale, N. and Gano, D.

DOI: 10.1016/j.siny.2024.101553

Aspergers syndrome " about time to rename it?

Pediatric Research

Bearer, C. and Abman, S.H. and Agostoni, C. and Ballard, P. and Bliss, J. and de Boode, W.P. and Canpolat, F.E. and Chalak, L. and Cilio, M.R. and Dammann, O. and Davis, J. and El-Metwally, D. and Ferriero, D. and Ford, S. and Fuentes-Afflick, E. and Gano, D. and Giussani, D. and Gonzalez, F. and Gunn, A. and Hogeveen, M. and Huang, A.Y. and Kaplan, J. and Klebanoff, M. and Lachman, P. and Mak, R. and Malhotra, A. and Miller, S. and Mitchell, W.B. and Molloy, E. and Mulkey, S.B. and Roland, D. and Sampath, V. and Sant?Anna, G. and Schaff, P. and Singer, L.T. and Stroustrup, A. and Tingay, D. and Tiribelli, C. and Toldi, G. and Tryggestad, J. and Valente, E.M. and Wilson-Costello, D. and Zupancic, J.

DOI: 10.1038/s41390-023-02885-8

Fetal Cerebral Ventriculomegaly: A Narrative Review and Practical Recommendations for Pediatric Neurologists

Pediatric Neurology

Agarwal, S. and Venkatesan, C. and Vollmer, B. and Scelsa, B. and Lemmon, M.E. and Pardo, A.C. and Mulkey, S.B. and Tarui, T. and Dadhwal, V. and Scher, M. and Hart, A.R. and Gano, D.

DOI: 10.1016/j.pediatrneurol.2024.04.016

Correspondence on Recognition and Management of Delirium in the Neonatal Intensive Care Unit: Case Series From a Single-Center Level IV Intensive Care Unit

Journal of Child Neurology

Chavez-Valdez, R. and Northington, F.J. and Sharp, A. and Burton, V.J. and Lammert, D.B. and Jantzie, L.L. and Robinson, S. and Stafstrom, C.E. and Ferriero, D. and Gano, D. and Numis, A. and Gerner, G. and Scafidi, J. and Gilmore, M. and Allen, M.C. and Hilberg, M. and Parkinson, C.

DOI: 10.1177/08830738241259054

Fetal Brain MRI Findings in Myotonic Dystrophy and Considerations for Prenatal Genetic Testing

Neurology Genetics

Shear, M.A. and Penon-Portmann, M. and Shieh, J.T. and Glenn, O.A. and Thiet, M.-P. and Chetty, S. and Sparks, T.N. and Gano, D.

DOI: 10.1212/NXG.0000000000200171

Pediatric Neurology in the Post-Roe Era

Pediatric Neurology

Gano, D. and Agarwal, S. and Khakoo, Y.

DOI: 10.1016/j.pediatrneurol.2023.10.001

Fetal Intraparenchymal Hemorrhage In Col4a1/2-related Disorders

Stroke

DOI: 10.1161/STR.54.SUPPL_1.TMP23

Declining Incidence of Postoperative Neonatal Brain Injury in Congenital Heart Disease

Journal of the American College of Cardiology

Peyvandi, S. and Xu, D. and Barkovich, A.J. and Gano, D. and Chau, V. and Reddy, V.M. and Selvanathan, T. and Guo, T. and Gaynor, J.W. and Seed, M. and Miller, S.P. and McQuillen, P.

DOI: 10.1016/j.jacc.2022.10.029

Spectrum of Fetal Intraparenchymal Hemorrhage in COL4A1/A2-Related Disorders

Pediatric Neurology

George, E. and Vassar, R. and Mogga, A. and Li, Y. and Norton, M.E. and Gano, D. and Glenn, O.A.

DOI: 10.1016/j.pediatrneurol.2023.07.008

Fetal Neurology Practice Survey (P10-9.001)

Neurology

DOI: 10.1212/WNL.0000000000201839

The Art, Science, and Secrets of Scanning Young Children

Biological Psychiatry

Spann, M.N. and Wisnowski, J.L. and Ahtam, B. and Gao, W. and Huang, H. and Nebel, M.B. and Norton, E.S. and Ouyang, M. and Rajagopalan, V. and Riggins, T. and Saygin, Z.M. and Scott, L. and Smyser, C.D. and Thomason, M.E. and Wakschlag, L.S. and Ahmad, S. and Aydin, E. and Barkovich, A.J. and Berger-Jenkins, E. and Brick, J. and Bowman, L.C. and Camacho, M.C. and Lugo-Candelas, C. and Cusack, R. and DuBois, J. and Dufford, A.J. and Elison, J.T. and Ellis, C.T. and Ferradal, S.L. and Filippi, C. and Ford, A.L. and Fouladivanda, M. and Gaab, N. and Gano, D. and Ganz-Benjaminsen, M. and Ghetti, S. and Glenn, O.A. and Castro Gomez, M.J. and Graham, A. and Hendrix, C.L. and Holland, C.M. and Humphreys, K. and Korom, M. and Kosakowski, H.L. and Li, G. and Manessis, A.G. and Nolvi, S. and Pineda, R. and Pollatou, A. and Rae, C. and Rasmussen, J.M. and Scheinost, D. and Shultz, S. and Simon-Martinez, C. and Madsen, K.S. and Sung, S. and Sylvester, C.M. and Turesky, T.K. and Vaughn, K.A. and Wagner, L. and Wang, L. and Warton, F.L. and Wilson, S. and Wintermark, P. and Wu, Y. and Yap, P.-T. and Yates, T.S. and Yen, E. and Yu, X. and Zhu, H. and Z{\"o}llei, L. and Howell, B. and Dean, D.C.

DOI: 10.1016/j.biopsych.2022.09.025

The Next Frontier in Neurology Is in Utero

JAMA Neurology

Russ, J.B. and Brown, J.E.H. and Gano, D.

DOI: 10.1001/jamaneurol.2023.2965

Fetal Neurology Practice Survey: Current Practice and the Future Directions

Pediatric Neurology

Tarui, T. and Venkatesan, C. and Gano, D. and Lemmon, M.E. and Mulkey, S.B. and Pardo, A.C. and Emrick, L. and Scher, M. and Agarwal, S.

DOI: 10.1016/j.pediatrneurol.2023.04.016

Child opportunity and social vulnerability indices are associated with language and cognitive outcomes at 4 years in term neonatal encephalopathy

Annals of Neurology

Advancing the Field of Fetal Neurology: A Call for Global Collaborations

Indian Pediatrics

Agarwal, S. and Venkatesan, C. and Tarui, T. and Gano, D.

DOI: 10.1007/s13312-023-3007-x

Proceedings of the 14th International Newborn Brain Conference: Neuro-imaging studies

Journal of Neonatal Perinatal Medicine

Herrera, S. and Cabacungan, E. and Cohen, S. and Thyagarajan, B. and Jefferies, K. and Avanaki, K. and Manwar, R. and McGuire, L. and Islam, T. and Shoo, A. and Charbel, F.T. and Pillers, D.-A.M. and Verschuur, A. and van Steenis, A. and Boswinkel, V. and Nijholt, I. and Boomsma, M. and Steggerda, S. and Meijler, G. and Leijser, L. and Park, S.G. and Yang, H.J. and Lim, S.Y. and Kim, S.H. and Shin, S.H. and Kim, E.-K. and Kim, H.-S. and Shiraki, A. and Kidokoro, H. and Watanabe, H. and Taga, G. and Narita, H. and Mitsumatsu, T. and Kumai, S. and Suzui, R. and Sawamura, F. and Ito, Y. and Yamamoto, H. and Nakata, T. and Sato, Y. and Hayakawa, M. and Natsume, J. and Buchmayer, J. and Kasprian, G. and Giordano, V. and Jernej, R. and Klebermass-Schrehof, K. and Berger, A. and Goeral, K. and Garvey, A. and El-Shibiny, H. and Yang, E. and Inder, T. and El-Dib, M. and Grant, E. and Manning, S. and Volpe, J. and Roychaudhuri, S. and Pineda, R. and Sharon, D. and Singh, E. and Steele, T. and Sheldon, Y. and Cuddyer, D. and Erdei, C. and Szakmar, E. and Andorka, C. and Barta, H. and Sesztak, T. and Varga, E. and Szabo, M. and Jermendy, A. and Panzarini, I. and King, R. and Hendson, L. and Carlson, H. and Scotland, J. and Zein, H. and Mohammed, K. and Bach, A. and Lambing, H. and Rogers, E.E. and Xu, D. and James, B.A. and Ferriero, D.M. and Glass, H.C. and Gano, D. and Igreja, L. and Ferreira, A. and Gomes, R. and Sousa, B. and Novo, A. and Alves, J.E. and Proen?a, E. and Carvalho, C.

DOI: 10.3233/NPM-239005

Parents' Views on Autopsy, Organ Donation, and Research Donation After Neonatal Death

JAMA Network Open

Crouch, E.E. and Damas, C. and Bartrug, W.C. and Shamiyeh, A. and Scelfo, M. and Dreyfus, M. and Gano, D. and Segal, S. and Franck, L.S.

DOI: 10.1001/jamanetworkopen.2023.41533

Using Neonatal Magnetic Resonance Imaging to Predict Gross Motor Disability at Four Years in Term-Born Children With Neonatal Encephalopathy

Pediatric Neurology

Lambing, H. and Gano, D. and Li, Y. and Bach, A.M. and Girvan, O. and Rogers, E.E. and Ferriero, D.M. and Barkovich, A.J. and Xu, D. and McCulloch, C.E. and Glass, H.C.

DOI: 10.1016/j.pediatrneurol.2023.03.011

The impact of in utero transfusions on perinatal outcomes in patients with alpha thalassemia major: the UCSF registry

Blood Advances

Schwab, M.E. and Lianoglou, B.R. and Gano, D. and Velez, J.G. and Allen, I.E. and Arvon, R. and Baschat, A. and Bianchi, D.W. and Bitanga, M. and Bourguignon, A. and Brown, R.N. and Chen, B. and Chien, M. and Davis-Nelson, S. and de Laat, M.W.M. and Ekwattanakit, S. and Gollin, Y. and Hirata, G. and Jelin, A. and Jolley, J. and Meyer, P. and Miller, J. and Norton, M.E. and Ogasawara, K.K. and Panchalee, T. and Schindewolf, E. and Shaw, S.W. and Stumbaugh, T. and Thompson, A.A. and Towner, D. and Stacy Tsai, P.-J. and Viprakasit, V. and Volanakis, E. and Zhang, L. and Vichinsky, E. and MacKenzie, T.C.

DOI: 10.1182/bloodadvances.2022007823

Proceedings of the 14th International Newborn Brain Conference: Fetal and/or neonatal brain development, both normal and abnormal

Journal of Neonatal Perinatal Medicine

Abdi, K. and Adams, E. and Agarwal, S. and Ergun, M.A. and Altamimi, T. and Aral, A. and Arfi, H. and Armour, E. and Armstrong, L. and Mulkey, S.B. and Bambi, J. and Baxter, L. and Benner, E. and Bhattacharya, S. and Biselele, T. and Bolay, H. and Mayorga, P.C. and Carrasco, M. and Carter, E. and Chao, A. and Cooke, A. and Corsi-Cabrera, M. and Cubero-Rego, L. and Cuddyer, D. and Gano, D.D. and Cubero-Rego, M.L.A. and de Ribaupierre, S. and Drobyshevsky, A. and El-Dib, M. and Elmazoglu, Z. and Emrick, L. and Epstein, A. and Erdei, C. and Flynn, P. and Duerden, E.G. and Gibson, K. and Gregory, S. and Topa, E.G.A. and Aliyu, M.H. and Harmony, T. and Harshbarger, J. and Hartley, C. and Hayakawa, M. and Kazan, H.H. and Inder, T. and Ito, Y. and Jain, V. and Jurkiewicz, M. and Kapoor, B. and Kebaya, L. and Keles Gulnerman, E. and Kidokoro, H. and Kling, E. and Kumai, S. and Lebane, D. and Lemmon, M. and Salihu, H.M. and Marchant, S. and Maxfield, C. and Mbayabo, G. and Meyerink, P. and Millman, R. and Mitsumatsu, T. and Nakata, T. and Narita, H. and Natsume, J. and Pacheco, J. and Pagano, L. and Pardo, A. and Peyton, C. and Pineda, R. and Reddy, S. and Ricardo-Garcell, J. and Rikard, B. and Roychaudhuri, S. and Nichols, E.S. and Sadowska-Krawczenko, I. and Sato, Y. and Sawamura, F. and Scher, M. and Sharon, D. and Sheldon, Y. and Shiraki, A. and Singh, E. and Steele, T. and Suzui, R. and Tady, B.-P. and Taga, G. and Tarui, T. and Trapp, N. and Tristao, L. and Tuka, D. and Ushida, T. and Usman, F. and Venkatesan, C. and Watanabe, H. and Witulska-Alag{\"o}z, A. and Yamamoto, H. and Yarnykh, V. and Younge, N.

DOI: 10.3233/NPM-239001

Critical congenital heart disease beyond HLHS and TGA: neonatal brain injury and early neurodevelopment

Pediatric Research

Vassar, R. and Peyvandi, S. and Gano, D. and Cox, S. and Zetino, Y. and Miller, S. and McQuillen, P.

DOI: 10.1038/s41390-023-02490-9

Relationship between social support and post-discharge mental health symptoms in mothers of preterm infants

Journal of Reproductive and Infant Psychology

Haeusslein, L. and Gano, D. and Gay, C.L. and Kriz, R.M. and Bisgaard, R. and Vega, M. and Cormier, D.M. and Joe, P. and Walker, V. and Kim, J.H. and Lin, C. and Sun, Y. and Franck, L.S.

DOI: 10.1080/02646838.2021.1984404

MRI Findings in Prematurely-Born Adolescents and Young Adults Who Screen Positive for Autism Spectrum Disorder

Pediatric Neurology

Kim, H. and Kim, Y.S. and Leventhal, B.L. and Bishop, S. and Barkovich, A.J. and Gano, D.

DOI: 10.1016/j.pediatrneurol.2022.07.008

Long-term cognitive outcomes in term newborns with watershed injury caused by neonatal encephalopathy

Pediatric Research

Lee, B.L. and Gano, D. and Rogers, E.E. and Xu, D. and Cox, S. and James Barkovich, A. and Li, Y. and Ferriero, D.M. and Glass, H.C.

DOI: 10.1038/s41390-021-01526-2

Rate of head ultrasound abnormalities at one month in very premature and extremely premature infants with normal initial screening ultrasound

Pediatric Radiology

Liu, A.R. and Gano, D. and Li, Y. and Diwakar, M. and Courtier, J.L. and Zapala, M.A.

DOI: 10.1007/s00247-022-05285-y

Disorders of Neuronal Migration/Organization Convey the Highest Risk of Neonatal Onset Epilepsy Compared With Other Congenital Brain Malformations

Pediatric Neurology

Simmons, R. and Martinez, A.B. and Barkovich, J. and Numis, A.L. and Cilio, M.R. and Glenn, O.A. and Gano, D. and Rogers, E.E. and Glass, H.C.

DOI: 10.1016/j.pediatrneurol.2021.11.005

Proceedings of the 13th International Newborn Brain Conference: Neuro-imaging studies

Journal of Neonatal Perinatal Medicine

Abramsky, R. and Acosta, R. and Acosta Izquierdo, L. and Albeshri, B. and Almouqdad, M. and Asfour, Y. and Asfour, S. and Austin, T. and Bach, A. and Barkovich, J. and Beare, R. and Ben Fadel, N. and Benner, E. and Berger, A. and Blanco, B. and Boomsma, M. and Bora, S. and Boswinkel, V. and Chao, A. and Chin, T. and Collins-Jones, L. and Cooper, R. and Dagur, G. and Davila, J. and de Vries, L. and Shesrao, L. and Dovjak, G. and Dubois, L. and Edwards, A. and El-Dib, M. and Elshibiny, H. and Eshel, D. and Eshel, R. and Ferriero, D. and Gano, D. and Girvan, O. and Glass, H. and Goeral, K. and Golan, A. and Goldberg, R.N. and Gregory, S. and Gurvitz, M. and Inder, T. and Jain, V. and Jamjoom, D. and Kadom, N. and Kasprian, G. and Khalil, T. and Klebermass-Schrehof, K. and Kleinmahon, J. and Kr{\"u}se-Ruijter, M. and Lambing, H. and Lee, S. and Leemans, A. and Leijser, L. and Lemyre, B. and Li, Y. and Maltais-Bilodeau, C. and Marks, K. and Matak, P. and McCulloch, C. and Milla, S. and Miller, E. and Mishra, A. and Mitsakakis, N. and Mohammad, K. and Tollenaer, S.M. and Munster, C. and Nijboer, J. and Nijboer-Oosterveld, J. and Nijholt, I. and Novoa, R. and Ortinau, C. and Pegram, K. and Porter, E. and Prayer, D. and Reddy, D. and Redpath, S. and Rogers, E. and Schmidbauer, V. and Scott, J. and Sewell, E. and Shany, E. and Shelef, I. and Singh, E. and Slump, C. and Steele, T. and Szakmar, E. and Tax, C. and Thiim, K. and Thompson, J.W. and Uchitel, J. and van Osch, J. and van Wezel-Meijler, G. and Verschuur, A. and Wu-Smit, M.-N. and Yang, E. and Younge, N. and Zein, H.

DOI: 10.3233/NPM-229001

TEMPORAL TRENDS OF NEONATAL BRAIN INJURY IN COMPLEX CONGENITAL HEART DISEASE: RESULTS FROM A 20 YEAR PROSPECTIVE COHORT STUDY

JACC: Journal of the American College of Cardiology

Neonatal brain injury influences structural connectivity and childhood functional outcomes

Plos One

Ramirez, A. and Peyvandi, S. and Cox, S. and Gano, D. and Xu, D. and Tymofiyeva, O. and McQuillen, P.S.

DOI: 10.1371/journal.pone.0262310

Reproductive Rights in Neurology - The Supreme Court's Impact on All of Us

JAMA Neurology

Lahue, S.C. and Gano, D. and Bove, R.

DOI: 10.1001/jamaneurol.2022.2347

Correction: Racial and ethnic disparities in outcomes through 1 year of life in infants born prematurely: a population based study in California (Journal of Perinatology, (2021), 41, 2, (220-231), 10.1038/s41372-021-00919-9)

Journal of Perinatology

Karvonen, K.L. and Baer, R.J. and Rogers, E.E. and Steurer, M.A. and Ryckman, K.K. and Feuer, S.K. and Anderson, J.G. and Franck, L.S. and Gano, D. and Petersen, M.A. and Oltman, S.P. and Chambers, B.D. and Neuhaus, J. and Rand, L. and Jelliffe-Pawlowski, L.L. and Pantell, M.S.

DOI: 10.1038/s41372-021-01004-x

Racial and ethnic disparities in outcomes through 1 year of life in infants born prematurely: a population based study in California

Journal of Perinatology

Karvonen, K.L. and Baer, R.J. and Rogers, E.E. and Steurer, M.A. and Ryckman, K.K. and Feuer, S.K. and Anderson, J.G. and Franck, L.S. and Gano, D. and Petersen, M.A. and Oltman, S.P. and Chambers, B.D. and Neuhaus, J. and Rand, L. and Jelliffe-Pawlowski, L.L. and Pantell, M.S.

DOI: 10.1038/s41372-021-00919-9

How does the convergence of prematurity and congenital heart disease impact the developing brain?

Seminars in Perinatology

Gano, D. and McQuillen, P.

DOI: 10.1016/j.semperi.2021.151472

Early Magnetic Resonance Imaging Predicts 30-Month Outcomes after Therapeutic Hypothermia for Neonatal Encephalopathy

Journal of Pediatrics

Bach, A.M. and Fang, A.Y. and Bonifacio, S. and Rogers, E.E. and Scheffler, A. and Partridge, J.C. and Xu, D. and Barkovich, A.J. and Ferriero, D.M. and Glass, H.C. and Gano, D.

DOI: 10.1016/j.jpeds.2021.07.003

Clinical Reasoning: A 2-Day-Old Boy With Sudden Cardiac Arrest and Encephalopathy

Neurology

Holmes, B.B. and Russ, J.B. and Wu, Y.W. and Gallagher, R.C. and Gano, D.

DOI: 10.1212/WNL.0000000000012408

Preterm neuroimaging: A fulcrum to advocate for earlier intervention

Seminars in Perinatology

Gano, D.

DOI: 10.1016/j.semperi.2021.151467

Bronchopulmonary dysplasia precursors influence risk of white matter injury and adverse neurodevelopmental outcome in preterm infants

Pediatric Research

Grelli, K.N. and Keller, R.L. and Rogers, E.E. and Partridge, J.C. and Xu, D. and Barkovich, A.J. and Gano, D.

DOI: 10.1038/s41390-020-01162-2

Migraines during Pregnancy and the Risk of Maternal Stroke

JAMA Neurology

Bandoli, G. and Baer, R.J. and Gano, D. and Pawlowski, L.J. and Chambers, C.

DOI: 10.1001/jamaneurol.2020.1435

Cerebral palsy after very preterm birth - an imaging perspective

Seminars in Fetal and Neonatal Medicine

Gano, D. and Cowan, F.M. and de Vries, L.S.

DOI: 10.1016/j.siny.2020.101106

Mid-pregnancy abnormalities in vascular endothelial growth factor (VEGF) and its receptors signal PPROM-specific risk

American Journal of Obstetrics and Gynecology

DOI: 10.1016/J.AJOG.2019.11.952

ASSOCIATION OF BRONCHOPULMONARY DYSPLASIA AND WHITE MATTER INJURY IN PRETERM INFANTS

Journal of Investigative Medicine

DOI: 10.1136/JIM-2018-000939.56

Pediatric out-of-hospital cardiac arrest: Time to goal target temperature and outcomes

Resuscitation

DOI: 10.1016/J.RESUSCITATION.2018.12.012

Introduction

Seminars in Pediatric Neurology

Gano, D. and Ferriero, D.M.

DOI: 10.1016/j.spen.2019.08.001

Cerebellar hypoplasia of prematurity: Causes and consequences

Handbook of Clinical Neurology

Gano, D. and Barkovich, A.J.

DOI: 10.1016/B978-0-444-64029-1.00009-6

Association of histologic chorioamnionitis with perinatal brain injury and early childhood neurodevelopmental outcomes among preterm neonates

JAMA Pediatrics

Bierstone, D. and Wagenaar, N. and Gano, D.L. and Guo, T. and Georgio, G. and Groenendaal, F. and De Vries, L.S. and Varghese, J. and Glass, H.C. and Chung, C. and Terry, J. and Rijpert, M. and Grunau, R.E. and Synnes, A. and Barkovich, A.J. and Ferriero, D.M. and Benders, M. and Chau, V. and Miller, S.P.

DOI: 10.1001/jamapediatrics.2018.0102

Focal Cerebral Infarction

Neurology Neonatology Questions and Controversies

Gano, D. and Ferriero, D.M.

DOI: 10.1016/B978-0-323-54392-7.00006-6

PATTERNS OF INJURY AND NEURODEVELOPMENTAL OUTCOMES IN A PROSPECTIVE COHORT OF NEONATAL ENCEPHALOPATHY

Journal of Investigative Medicine

DOI: 10.1136/JIM-2017-000663.412

Aberrant structural brain connectivity in adolescents with attentional problems who were born prematurely

American Journal of Neuroradiology

Tymofiyeva, O. and Gano, D. and Trevino, R.J. and Glass, H.C. and Flynn, T. and Lundy, S.M. and McQuillen, P.S. and Ferriero, D.M. and Barkovich, A.J. and Xu, D.

DOI: 10.3174/ajnr.A5834

Outcomes After Acute Symptomatic Seizures in Children Admitted to a Neonatal Neurocritical Care Service

Pediatric Neurology

Glass, H.C. and Numis, A.L. and Gano, D. and Bali, V. and Rogers, E.E.

DOI: 10.1016/j.pediatrneurol.2018.03.016

Neonatal stroke

Fetal and Neonatal Brain Injury

Gano, D. and Ferriero, D.M.

DOI: 10.1017/9781316275498.026

Altered Cerebellar Development in Preterm Newborns: Chicken or Egg?

Journal of Pediatrics

Gano, D. and Ferriero, D.M.

DOI: 10.1016/j.jpeds.2016.11.060

Microstructure of the default mode network in preterm infants

American Journal of Neuroradiology

Cui, J. and Tymofiyeva, O. and Desikan, R. and Flynn, T. and Kim, H. and Gano, D. and Hess, C.P. and Ferriero, D.M. and Barkovich, A.J. and Xu, D.

DOI: 10.3174/ajnr.A4997

Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy

Neuroimage Clinical

Shapiro, K.A. and Kim, H. and Mandelli, M.L. and Rogers, E.E. and Gano, D. and Ferriero, D.M. and Barkovich, A.J. and Gorno-Tempini, M.L. and Glass, H.C. and Xu, D.

DOI: 10.1016/j.nicl.2017.06.015

Relationship Between Sociodemographics, Prenatal Care and Brain Injury in Preterm Newborns

Annals of Neurology

Perinatal neuroprotection update.

F1000research

Jelin, A.C. and Salmeen, K. and Gano, D. and Burd, I. and Thiet, M.-P.

DOI: 10.12688/F1000RESEARCH.8546.1

DECREASED RISK OF CEREBELLAR HEMORRHAGE IN PREMATURE NEWBORNS EXPOSED TO ANTENATAL MAGNESIUM SULFATE

Journal of Investigative Medicine

DOI: 10.1136/JIM-D-15-00013.348

Hindbrain regional growth in preterm newborns and its impairment in relation to brain injury

Human Brain Mapping

Kim, H. and Gano, D. and Ho, M.-L. and Guo, X.M. and Unzueta, A. and Hess, C. and Ferriero, D.M. and Xu, D. and Barkovich, A.J.

DOI: 10.1002/hbm.23058

Motor and Cognitive Outcomes in Preterm Newborns with Mild White Matter Injury

Annals of Neurology

DOI: 10.1136/JIM-2016-000365.137

Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns

Journal of Pediatrics

Gano, D. and Ho, M.-L. and Partridge, J.C. and Glass, H.C. and Xu, D. and Barkovich, A.J. and Ferriero, D.M.

DOI: 10.1016/j.jpeds.2016.06.053

White matter injury in premature newborns

Neonatal Network

Gano, D.

DOI: 10.1891/0730-0832.35.2.73

Impaired cognitive performance in premature newborns with two or more surgeries prior to term-equivalent age

Pediatric Research

Gano, D. and Andersen, S.K. and Glass, H.C. and Rogers, E.E. and Glidden, D.V. and Barkovich, A.J. and Ferriero, D.M.

DOI: 10.1038/pr.2015.106

Diminished white matter injury over time in a cohort of premature newborns

Journal of Pediatrics

Gano, D. and Andersen, S.K. and Partridge, J.C. and Bonifacio, S.L. and Xu, D. and Glidden, D.V. and Ferriero, D.M. and Barkovich, A.J. and Glass, H.C.

DOI: 10.1016/j.jpeds.2014.09.009

Impaired Cognitive Performance after Exposure to Anesthesia in Premature Newborns

Annals of Neurology

Evolution of pattern of injury and quantitative MRI on days 1 and 3 in term newborns with hypoxic-ischemic encephalopathy

Pediatric Research

Gano, D. and Chau, V. and Poskitt, K.J. and Hill, A. and Roland, E. and Brant, R. and Chalmers, M. and Miller, S.P.

DOI: 10.1038/pr.2013.69

MRI findings in infants with infantile spasms after neonatal hypoxic-ischemic encephalopathy

Pediatric Neurology

Gano, D. and Sargent, M.A. and Miller, S.P. and Connolly, M.B. and Wong, P. and Glass, H.C. and Poskitt, K.J. and Chau, V.

DOI: 10.1016/j.pediatrneurol.2013.08.007

Decreased Non-Cystic White Matter Injury in Premature Newborns Over Time

Annals of Neurology

Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis

Journal of Neuroimmunology

O{'}Connor, K.C. and Lopez-Amaya, C. and Gagne, D. and Lovato, L. and Moore-Odom, N.H. and Kennedy, J. and Krupp, L. and Tenembaum, S. and Ness, J. and Belman, A. and Boyko, A. and Bykova, O. and Mah, J.K. and Stoian, C.A. and Waubant, E. and Kremenchutzky, M. and Ruggieri, M. and Bardini, M.R. and Rensel, M. and Hahn, J. and Weinstock-Guttman, B. and Yeh, E.A. and Farrell, K. and Freedman, M.S. and Iivanainen, M. and Bhan, V. and Dilenge, M. and Hancock, M.A. and Gano, D. and Fattahie, R. and Kopel, L. and Fournier, A.E. and Moscarello, M. and Banwell, B. and Bar-Or, A.

DOI: 10.1016/j.jneuroim.2010.02.019

Correlation of Apgar Scores with Patterns of Brain Injury in Term Newborns with Hypoxic-Ischemic Encephalopathy

Annals of Neurology

Comparison of Quantitative Diffusion and MR Spectroscopic Parameters at 24 and 72 Hours of Life in Term Newborns with Hypoxic-Ischemic Encephalopathy

Annals of Neurology

Acute treatment of paediatric migraine: A meta-analysis of efficacy

Journal of Paediatrics and Child Health

Silver, S. and Gano, D. and Gerretsen, P.

DOI: 10.1111/j.1440-1754.2007.01206.x

Tuberous sclerosis complex in a patient with epilepsy, developmental delay and normal neuroimaging

Journal of Investigative Medicine

Natalizumab effects on immune cell responses in multiple sclerosis

Annals of Neurology

Niino, M. and Bodner, C. and Simard, M.-L. and Alatab, S. and Gano, D. and Kim, H.J. and Trigueiro, M. and Racicot, D. and Gu{\'e}rette, C. and Antel, J.P. and Fournier, A. and Grand{'}Maison, F. and Bar-Or, A.

DOI: 10.1002/ana.20859

Prospective monitoring of in vivo biological effects of natalizurnalb (AVLA-4, Tysabri) in patients with MS

Clinical Immunology

DOI: 10.1016/J.CLIM.2006.04.422

Erratum: Natalizumab effects on immune cell responses in multiple sclerosis (Annals of Neurology (2006) 59 (748-754))

Annals of Neurology

Niino, M. and Bodner, C. and Simard, M.-L. and Alatab, S. and Gano, D. and Kim, H.J. and Trigueiro, M. and Racicot, D. and Gu{\'e}rette, C. and Antel, J.P. and Fournier, A. and Grand{'}Maison, F. and Bar-Or, A.

DOI: 10.1002/ana.20908

Anti-myelin antibodies in pediatric MS

Neurology

Effects of natalizumab (anti-VLA-4 antibody) on immune cell adhesion and migration in patients with MS

Clinical Immunology

Regulated expression of Nogo and Nogo receptor on activated immune cells: Significance for multiple sclerosis

Neurology

Multicenter Registry of Fetal Ventriculomegaly

Fetal ventriculomegaly is among the most common neurological conditions identified prenatally, affecting up to 1% of all pregnancies. This contemporary cohort study of fetal ventriculomegaly will examine the etiologies and perinatal outcomes of fetal ventriculomegaly from centers across Canada and the United States to address key knowledge gaps that impact counseling and care. The second phase of this study will evaluate developmental outcomes in early childhood.

Coagulation Biomarkers of Post-Hemorrhagic Ventriculomegaly in Preterm Newborns (CoVe study)

With collaborators at the University of California, San Francisco (UCSF), including co-Principal Investigator Dr. Mark Petersen, we prospectively recruited 50 very preterm newborns, and collected serial plasma and urine samples. We are examining the association of markers of coagulation, oxidative stress and neurodegeneration with intraventricular hemorrhage, as well as posthemorrhagic ventricular dilatation and hydrocephalus. Proteomic analysis of >1100 plasma proteins and analysis of a subset of urine biomarkers of brain injury is underway.

Trexo-Robotic Exoskeleton Training in Young Children with Cerebral Palsy (T-REx study)

New technologies are offering new opportunities to promote mobility in children with motor impairment. The purpose of this study is to examine the acceptability and feasibility of robotic exoskeleton training in children aged 1-3 years diagnosed with, or at high risk for, cerebral palsy.

Grants

Principal Investigator. TREx Study: Trexo Robotic exoskeleton training program in non-ambulatory children <2 years. Funding Source: Cerebral Palsy Alliance Research Foundation Program Grant

Co-Principal Investigator. Coagulation Biomarkers of Post-Hemorrhagic Ventriculomegaly in Preterm Newborns. Funding Source: California Preterm Birth Initiative Innovation Award

Co-Investigator. Does Preterm Birth Amplify Brain Injury and Dysmaturation In Congenital Heart Disease? Funding Source: National Institutes of Health / National Heart, Lung, and Blood Institute

Co-Investigator. Phase 1 Study of In Utero Enzyme Replacement Therapy for the Treatment of Lysosomal Storage Diseases. Funding Source: National Institutes of Health / Eunice Kennedy Shriver National Institute of Child Health & Human Development

Co-Investigator. Maternal Antecedents and Electronic Fetal Monitoring in Term Asphyxia. Funding Source: National Institutes of Health / Eunice Kennedy Shriver National Institute of Child Health & Human Development

Co-Investigator. In utero hematopoietic stem cell transplantation for the treatment of fetuses with alpha thalassemia major (phase I). Funding Source: California Institute for Regenerative Medicine (CIRM)

Honours & Awards

2024 - Exceptional Physician Award, UCSF Health

2023 - Excellence in Teaching Award, UCSF School of Medicine and Haile T. Debas Academy of Medical Educators

2018 - Elected member, Society for Pediatric Research

2017 - Short-Term Mentor Award, UCSF School of Medicine

2015 - Melvin B. Grumbach Award for Excellence in Research, UCSF Department of Pediatrics

2010 - Outstanding Junior Member, Child Neurology Society

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

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