Gregor Reid
BSc, PhD
Investigator, Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital
Cancer Medicine
Luis Gil-de-Gmez and Joseph J. Mattei and Jessica H. Lee and Stephan A. Grupp and Gregor S. D. Reid and Alix E. Seif
DOI: 10.1002/cam4.7050801 / 2025
Biopreservation and biobanking
Tanmaya Atre and Nguyen V and Chow V and Reid GSD and Suzanne Vercauteren
DOI: 10.1089/bio.2023.0133 PubMed: 3868664504 / 2024
Leukemia
Farrokhi A and Tanmaya Atre and Jenna Rever and Fidanza M and Duey W and Samuel Salitra and Myung J and Guo M and Sumin Jo and Uzozie A and Fatemeh (Shakiba) Baharvand and Nina Rolf and Franziska Auer and Hauer J and Stephan Grupp and Eydoux P and Philipp F. Lange and Alix Seif and Christoper A. Maxwell and Gregor Reid
DOI: 10.1038/s41375-024-02221-x PubMed: 3851979803 / 2024
Nature Communications
Amanda C. Lorentzian and Jenna Rever and Enes K. Ergin and Meiyun Guo and Neha M. Akella and Nina Rolf and C. James Lim and Gregor S. D. Reid and Christopher A. Maxwell and Philipp F. Lange
DOI: 10.1038/s41467-023-42701-911 / 2023
Blood Advances
Tanmaya Atre and Ali Farrokhi and Sumin Jo and Samuel Salitra and Jesus Duque-Afonso and Michael L. Cleary and Nina Rolf and Gregor S. D. Reid
DOI: 10.1182/bloodadvances.202301078211 / 2023
Cancers
Guo M and Jenna Rever and Phuong N.U. Nguyen and Neha Manjari Akella and Reid GSD and Chris Maxwell
DOI: 10.3390/cancers15010154 PubMed: 3661215012 / 2022
European Journal of Pharmaceutical Sciences
A Tam and J Kulkarni and K An and L Li and DR Dorscheid and GK Singhera and P Bernatchez and GSD Reid and KYT Chan and D Witzigmann and PR Cullis and DD Sin and CJ Lim
DOI: 10.1016/j.ejps.2022.10623409 / 2022
Cytometry Part A
Nina Rolf and Lorraine Y. T. Liu and Angela Tsang and Philipp F. Lange and Chinten James Lim and Christopher A. Maxwell and Suzanne M. Vercauteren and Gregor S. D. Reid
DOI: 10.1002/cyto.a.2447301 / 2022
Cell transplantation
Ali Farrokhi and Rahavi M and Jo S and Jalili R and Chinten James Lim and Ghahsary A and Reid GSD
DOI: 10.1177/09636897221113803 PubMed: 3591295401 / 2022
Journal of Experimental & Clinical Cancer Research
Anuli C. Uzozie and Enes K. Ergin and Nina Rolf and Janice Tsui and Amanda Lorentzian and Samuel S. H. Weng and Lorenz Nierves and Theodore G. Smith and C. James Lim and Christopher A. Maxwell and Gregor S. D. Reid and Philipp F. Lange
DOI: 10.1186/s13046-021-01835-812 / 2021
Proceedings of the National Academy of Sciences
Hong Bing Yu and Hyungjun Yang and Joannie M. Allaire and Caixia Ma and Franziska A. Graef and Arthur Mortha and Qiaochu Liang and Else S. Bosman and Gregor S. Reid and James A. Waschek and Lisa C. Osborne and Harry Sokol and Bruce A. Vallance and Kevan Jacobson
DOI: 10.1073/pnas.210663411810 / 2021
Cancers
DOI: 10.3390/cancers12010169 PubMed: 3201529801 / 2020
Pediatric hematology and oncology
DOI: 10.1080/08880018.2019.1667461 PubMed: 3153024009 / 2019
JNCI cancer spectrum
DOI: 10.1093/jncics/pky079 PubMed: 3097675010 / 2018
Cell Death & Disease
Pascal Leclair and Chi-Chao Liu and Mahdis Monajemi and Gregor S. Reid and Laura M. Sly and Chinten James Lim
DOI: 10.1038/s41419-018-0601-205 / 2018
Cell Death & Disease
Anthony C Tang and Seyed M Rahavi and Shan-Yu Fung and Henry Y Lu and Hong Yang and Chinten J Lim and Gregor S Reid and Stuart E Turvey
DOI: 10.1038/s41419-017-0194-102 / 2018
Cancer Immunology, Immunotherapy
10 / 2017
Leukemia
09 / 2017
European Journal of Immunology
Mario Fidanza and Alix E. Seif and Sumin Jo and Amina Kariminia and Nina Rolf and Laura M. Sly and Stephan A. Grupp and Gregor S. D. Reid
DOI: 10.1002/eji.20164680605 / 2017
Leukemia
DOI: 10.1038/leu.2016.152.06 / 2016
Cell death & disease
Liu, C-C and Leclair, P and Monajemi, M and Sly, L M and Reid, G S and Lim, C J
DOI: 10.1038/cddis.2016.176European Journal of Immunology
Rolf, Nina and Kariminia, Amina and Ivison, Sabine and Reid, Gregor S. and Schultz, Kirk R.
DOI: 10.1002/eji.201444874Journal of Leukocyte Biology
Kozicky, Lisa K. and Zhao, Zheng Yu and Menzies, Susan C. and Fidanza, Mario and Reid, Gregor S. D. and Wilhelmsen, Kevin and Hellman, Judith and Hotte, Naomi and Madsen, Karen L. and Sly, Laura M.
DOI: 10.1189/jlb.3VMA0315-078RBlood
Barrett, D. M. and Seif, A. E. and Carpenito, C. and Teachey, D. T. and Fish, J. D. and June, C. H. and Grupp, S. A. and Reid, G. S. D.
DOI: 10.1182/blood-2011-04-346528Blood
Seif, Alix E. and Barrett, David M. and Milone, Michael and Brown, Valerie I. and Grupp, Stephan A. and Reid, Gregor S. D.
DOI: 10.1182/blood-2009-02-203984Clinical Cancer Research
Reid, Gregor S. D. and Shan, Xiaochuan and Coughlin, Christina M. and Lassoued, Wiem and Pawel, Bruce R. and Wexler, Leonard H. and Thiele, Carol J. and Tsokos, Maria and Pinkus, Jack L. and Pinkus, Geraldine S. and Grupp, Stephan A. and Vonderheide, Robert H.
DOI: 10.1158/1078-0432.CCR-09-0829Blood
Teachey, David T. and Sheen, Cecilia and Hall, Junior and Ryan, Theresa and Brown, Valerie I. and Fish, Jonathan and Reid, Gregor S. D. and Seif, Alix E. and Norris, Robin and Chang, Yueh J. and Carroll, Martin and Grupp, Stephan A.
DOI: 10.1182/blood-2008-02-137141British Journal of Haematology
Barbaric, Draga and Corthals, Sophie L. and Jastaniah, Wasil A. and Asalanian, Soudabeh and Shimizu, Hiromi and Reid, Gregor S. D. and Schultz, Kirk R.
DOI: 10.1111/j.1365-2141.2008.07001.xBlood
Teachey, David T. and Seif, Alix E. and Brown, Valerie I. and Bruno, Marlo and Bunte, Ralph M. and Chang, Yueh J. and Choi, John K. and Fish, Jonathan D. and Hall, Junior and Reid, Gregor S. and Ryan, Theresa and Sheen, Cecilia and Zweidler-McKay, Patrick and Grupp, Stephan A.
DOI: 10.1182/blood-2007-05-087353Immunologic Research
Brown, Valerie I. and Seif, Alix E. and Reid, Gregor S. D. and Teachey, David T. and Grupp, Stephan A.
DOI: 10.1007/s12026-008-8038-9Biology of Blood and Marrow Transplantation
She, Kevin and Gilman, Andrew L. and Aslanian, Soudabeh and Shimizu, Hiromi and Krailo, Mark and Chen, Zhengjia and Reid, Gregor S. and Wall, Donna and Goldman, Fred and Schultz, Kirk R.
DOI: 10.1016/j.bbmt.2006.12.441Blood
Fujii, Hisaki and Trudeau, Jacqueline D. and Teachey, David T. and Fish, Jonathan D. and Grupp, Stephan A. and Schultz, Kirk R. and Reid, Gregor S. D.
DOI: 10.1182/blood-2006-02-002055British Journal of Haematology
Corthals, SL and Wynne, K and She, K and Shimizu, H and Curman, D and Garbutt, K and Reid, GSD
DOI: 10.1111/j.1365-2141.2005.05893.xLeukemia Research
Jastaniah, WA and Alessandri, AJ and Reid, GSD and Schultz, KR
DOI: 10.1016/j.leukres.2005.08.013Blood
Reid, GSD and She, K and Terrett, L and Food, MR and Trudeau, JD and Schultz, KR
DOI: 10.1182/blood-2004-06-2468Leukemia Research
Barbaric, D and Wynne, K and Aslanian, S and Bond, M and Reid, GSD
DOI: 10.1016/j.leukres.2005.01.002Leukemia
Imai, C and Ross, ME and Reid, G and Coustan-Smith, E and Schultz, KR and Pui, CH and Downing, JR and Campana, D
DOI: 10.1038/sj.leu.2403349International Immunology
Qin, HL and Trudeau, JD and Reid, GSD and Lee, IF and Dutz, JP and Santamaria, P and Verchere, CB and Tan, RS
DOI: 10.1093/intimm/dxh167Journal of Pediatrics
Currie, AJ and Davidson, DJ and Reid, GSD and Bharya, S and MacDonald, KL and Devon, RS and Speert, DP
DOI: 10.1016/j.jpeds.2003.10.034Journal of Immunology
Davidson, DJ and Currie, AJ and Reid, GSD and Bowdish, DME and MacDonald, KL and Ma, RC and Hancock, REW and Speert, DP
Leukemia Research
Reid, GSD and Terrett, L and Alessandri, AJ and Grubb, S and Stork, L and Seibel, N and Gaynon, P and Schultz, KR
DOI: 10.1016/S0145-2126(03)00106-1Clinical and Experimental Immunology
Reid, GSD and Bharya, S and Klingemann, HG and Schultz, KR
DOI: 10.1046/j.1365-2249.2002.01919.xBritish Journal of Haematology
Alessandri, AJ and Reid, GSD and Bader, SA and Massing, BG and Sorensen, PHB and Schultz, KR
DOI: 10.1046/j.1365-2141.2002.03291.xNature Biotechnology
Alimonti, J and Zhang, QJ and Gabathuler, R and Reid, G and Chen, SS and Jefferies, WA
Journal of Cell Biology
Gabathuler, R and Alimonti, J and Zhang, QJ and Kolaitis, G and Reid, G and Jefferies, WA
DOI: 10.1083/jcb.140.1.17Biochemistry
Marusina, K and Reid, G and Gabathuler, R and Jefferies, W and Monaco, JJ
DOI: 10.1021/bi9619738Journal of Biological Chemistry
FOOD, MR and ROTHENBERGER, S and GABATHULER, R and HAIDL, ID and REID, G and JEFFERIES, WA
Journal of Experimental Medicine
GABATHULER, R and REID, G and KOLAITIS, G and DRISCOLL, J and JEFFERIES, WA
DOI: 10.1084/jem.180.4.1415Journal of Insect Physiology
BOWNES, M and REID, G
DOI: 10.1016/0022-1910(90)90097-YImmune influence on ALL development. Infection has long been postulated to play a role in the progression of childhood ALL. Using novel models of this disease we are actively identifying the influence of the immune system during a pre-leukemic state on the onset of ALL. Our research indicates that the immune system may exert considerable control over early pre-leukemic cell expansion, but other mechanisms, such as growth factor availability, may also be important. Our long-term goal is to identify the growth constraints on pre-leukemic expansion, understand the influence of infection on these constraints, and use this knowledge to develop targeted strategies to reduce the incidence of primary disease and relapse.
Immune therapy for acute lymphoblastic leukemia (ALL). This research addresses the issue of ALL immunogenicity and the induction of anti-ALL immune activity as a strategy to eradicate residual disease after chemotherapy. Our work has described the ability of immunostimulatory DNA (CpG ODN) treatment both to enhance the immunogenicity of primary human ALL blasts and to stimulate significant anti-ALL immune activity resulting in T cell-mediated protection against disease progression. This work provided the first report of immune-mediated killing of primary human ALL in vivo in the absence of adoptive transfer of lymphocytes or stem cell transplantation, and indicates that toll-like receptor signaling may provide a clinically feasible strategy for augmenting immune responses against ALL. A clinical trial based on this approach is aboout to commence. The next major step in our development of CpG ODN as an immune therapy for ALL will involve the examination of their ability to induce anti-leukemia immune activity after chemotherapy in a spontaneous mouse model of ALL, and to generate ALL-specific T cells against autologous leukemia blasts from patients. By using such models, in which immune tolerance must be overcome, this ongoing work will be the most stringent pre-clinical testing yet of an immune therapy for pediatric leukemia. The goal of these studies is to provide insights that will optimize the clinical application of this approach.
Canadian Institutes of Health Research
Canadian Cancer Society
Leukemia & Lymphoma Society of Canada
Every day, our researchers work towards breakthroughs to transform the lives of kids in BC and around the world. Learn about our latest innovations and advancements in child health.
Congratulations to the BC Children’s Hospital Research Institute (BCCHR), Women’s Health Research Institute (WHRI), and Vancouver Coastal Health Research Institute (VCHRI) investigators and their teams who were awarded funding through the Canadian Institutes of Health Research (CIHR) Spring 2024 Project Grant competition. Several of our research community members received around $5 million in new research…
Congratulations to BC Children’s Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded funding through the Canadian Institute of Health Research (CIHR) Fall 2023 Project Grant competition. Our research community received around $11 million in new research grants as principal investigators or co-investigators.
For the first time ever, BC Children’s Hospital Research Institute has produced a mini Year in Review to publicly share a snapshot of research accomplished during the past fiscal year.
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BC Children's Hospital Research Institute operates on the ancestral and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. Further, this acknowledgement, gratitude, and respect extends to all of the First Nations communities on whose territories the Research Institute builds relationships and operates in British Columbia.
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