Roxane Carr

BSc, BScPharm, PharmD

Investigator, BC Children's Hospital

Dr Roxane Carr’s research focus is to study the safety and effectiveness of drugs used to treat a variety of illnesses in children. She is also interested in studying the impact of various treatment modalities (extracorporeal life support (heart-lung machine), dialysis, and therapeutic plasma exchange (plasmapharesis) on drug dosing in children as well as optimal methods to monitor the drug therapy of children and for pharmacists to communicate about drug therapy issues with children and their care givers.

Academic Affiliations

  • Clinical Instructor, Faculty of Pharmaceutical Sciences, University of British Columbia
  • Research Theme: Evidence to Innovation
  • Research Group(s): Clinical Pharmacology; Clinical Practice, Outcomes and Innovation

Contact Information

Assistant

Lynne Taylor

lxtaylor@cw.bc.ca

Location

4500 Oak st, Vancouver, BC, Canada, V6H 3N1

Safety of Cefazolin in Pregnant Patients with Documented Penicillin Allergy: A Retrospective Cohort Study

Canadian Journal of Hospital Pharmacy

Caitlin Chew and Roxane Carr and Chelsea Elwood and Vanessa Paquette

DOI: 10.4212/cjhp.3774

10 / 2025

True Rate of Allergy among Pediatric Inpatients with Penicillin Allergy Labels (TRIAL)

Canadian Journal of Hospital Pharmacy

Kwan, N. and Kang, K. and Carr, R.R. and Mak, R. and Roberts, A. and Jin, F. and Bone, J.N. and Rassekh, S.R. and Wong, T.

DOI: 10.4212/cjhp.3531

Effectiveness of Alprostadil for Ductal Patency

Journal of Pediatric Pharmacology and Therapeutics

Gordon, C.M. and Tan, J.T. and Carr, R.R.

DOI: 10.5863/1551-6776-29.1.37

Clinical pathway development to standardize pharmacological medication management of agitation in pediatric inpatient settings

Journal of the Canadian Academy of Child and Adolescent Psychiatry

Wood, M.D. and Gandhi, K. and Elbe, D. and Saran, K. and Leung, S. and McKay, J. and Carr, R. and Chapman, A.

Describing Intravenous Extravasation Injuries in Children (DIVE2 Study)

Canadian Journal of Hospital Pharmacy

Devsi, J.A. and Paquette, V. and Carr, R.R.

DOI: 10.4212/cjhp.3525

A Review of Histamine-2 Receptor Antagonist and Proton Pump Inhibitor Therapy for Gastroesophageal Reflux Disease in Neonates and Infants

Pediatric Drugs

Tan, J. and Jeffries, S. and Carr, R.

DOI: 10.1007/s40272-023-00580-z

Characterizing the Use of Nabiximols (9-Tetrahydrocannabinol"Cannabidiol) Buccal Spray in Pediatric Patients

Canadian Journal of Hospital Pharmacy

Hagg, L. and Leung, S. and Carr, R.

DOI: 10.4212/cjhp.3349

Development and validation of the Pediatric Asthma kNowleDge and mAnagement (P.A.N.D.A) questionnaires

Journal of Asthma

Clara Levivien and Jennifer Kendrick and Roxane Carr

DOI: 10.1080/02770903.2021.1978482

10 / 2022

Comparison of Sodium Bicarbonate and Lactated Ringers Hydration for High-dose Methotrexate Chemotherapy in Children

Journal of Pediatric Hematology/Oncology

Kendrick, J. and Jacques, L. and Baadjes, B. and Carr, R.

DOI: 10.1097/MPH.0000000000002393

Navigating the complex realm of drug access in paediatric care

Paediatrics and Child Health (Canada)

Dean, P.H. and Carr, R. and Jensen, C. and Strahlendorf, C.

DOI: 10.1093/pch/pxab001

Conflict between pharmacy preceptors and pharmacy learners in experiential education

Canadian Journal of Hospital Pharmacy

Kendrick, J. and Beauchesne, A. and Lee, Y.V. and Corrigan, S. and Carr, R.

DOI: 10.4212/CJHP.V74I1.3044

Analysis of knowledge evaluation tools for pediatric patients participating in an asthma education program,Analyse des outils d'valuation des connaissances pour les patients pdiatriques participant un programme d'ducation sur l'asthme

Journal de Pharmacie Clinique

Levivien, C. and Carr, R. and Curatolo, N. and Rieutord, A.

DOI: 10.1684/jpc.2019.0420

Survey of therapeutic drug monitoring practices in pediatric health care programs across Canada

Canadian Journal of Hospital Pharmacy

Leung, D. and Ensom, M.H.H. and Carr, R.

RELATE: Relationship of limited sampling strategy and adverse effects of mycophenolate mofetil in pediatric renal transplant patients

Pediatric Transplantation

Berger, I. and Haubrich, K. and Ensom, M.H.H. and Carr, R.

DOI: 10.1111/petr.13355

Pharmacologic Management of Agitation and Aggression in a Pediatric Emergency Department " A Retrospective Cohort Study

The Journal of Pediatric Pharmacology and Therapeutics

DOI: 10.5863/1551-6776-23.6.455

11 / 2018

A naloxone admixture to prevent opioid-induced pruritus in children: a randomized controlled trial,Un mlange de naloxone pour prvenir le prurit induit par les opiacs chez les enfants: une tude randomise contrle

Canadian Journal of Anesthesia

West, N. and Ansermino, J.M. and Carr, R.R. and Leung, K. and Zhou, G. and Lauder, G.R.

DOI: 10.1007/s12630-015-0380-5

Pediatric Obesity: Pharmacokinetics and Implications for Drug Dosing

Clinical Therapeutics

Kendrick, J.G. and Carr, R.R. and Ensom, M.H.H.

DOI: 10.1016/j.clinthera.2015.05.495

Pediatric Assessment of Vancomycin Empiric Dosing (PAVED): a Retrospective Review

Pediatric Drugs

Rainkie, D. and Ensom, M.H.H. and Carr, R.

DOI: 10.1007/s40272-015-0122-8

Standard-dose versus high-dose acyclovir in children treated empirically for encephalitis: A retrospective cohort study of its use and safety

Pediatric Drugs

Kendrick, J.G. and Ensom, M.H.H. and Steer, A. and White, C.T. and Kwan, E. and Carr, R.R.

DOI: 10.1007/s40272-014-0066-4

Stability of epinephrine at standard concentrations

Canadian Journal of Hospital Pharmacy

Carr, R.R. and Decarie, D. and Ensom, M.H.H.

DOI: 10.4212/cjhp.v67i3.1356

The invisible white coat: Awareness of pharmacists in a neonatal intensive care unit

Canadian Journal of Hospital Pharmacy

Bajwa, R. and Kendrick, J.G. and Carr, R.

DOI: 10.4212/cjhp.v67i4.1374

Evaluating preferences for long term wheeze following RSV infection using TTO and best-worst scaling

Allergy, Asthma & Clinical Immunology

Lilla MC Roy and Nick Bansback and Carlo Marra and Roxane Carr and Mark Chilvers and Larry D Lynd

DOI: 10.1186/1710-1492-10-s1-a64

A pharmacokinetics module taught within a pediatrics pharmacotherapy course

American Journal of Pharmaceutical Education

Gerber, P. and Carr, R.

DOI: 10.5688/ajpe776126

Safety and effectiveness of dexmedetomidine in the pediatric intensive care unit (SAD-PICU)

Canadian Journal of Hospital Pharmacy

Carney, L. and Kendrick, J. and Carr, R.

DOI: 10.4212/cjhp.v66i1.1208

Overview of antiarrhythmic drug therapy for supraventricular tachycardia in children

Progress in Pediatric Cardiology

Escudero, C. and Carr, R. and Sanatani, S.

DOI: 10.1016/j.ppedcard.2012.11.008

Compatibility and stability of morphine sulphate and naloxone hydrochloride in 0.9% sodium chloride for injection

Canadian Journal of Hospital Pharmacy

Kistner, C. and Ensom, M.H.H. and Decarie, D. and Lauder, G. and Carr, R.R.

DOI: 10.4212/cjhp.v66i3.1253

A systematic review of the pharmacokinetics of antiepileptic drugs in neonates with refractory seizures

Journal of Pediatric Pharmacology and Therapeutics

Tulloch, J. K., Carr, R. R., & Ensom, M. H. H. (2012). A Systematic Review of the Pharmacokinetics of Antiepileptic Drugs in Neonates With Refractory Seizures. The Journal of Pediatric Pharmacology and Therapeutics: JPPT, 17(1), 31"44. http://doi.org/10.5863/1551-6776-17.1.31

DOI: 10.5863/1551-6776-17.1.31

02 / 2012

Canadian survey of critical care pharmacists' views and involvement in clinical research,Estudio canadiense sobre la implicacin de los farmacuticos de cuidados crticos en investigacin clnica y sus opiniones en torno a ESTE tema

Annals of Pharmacotherapy

Perreault, M.M. and Thiboutot, Z. and Burry, L.D. and Rose, L. and Kanji, S. and Leblanc, J.M. and Carr, R.R. and Williamson, D.R.

DOI: 10.1345/aph.1R180

Use of methadone for prevention of opioid withdrawal in critically Ill children

Canadian Journal of Hospital Pharmacy

Jeffries, S.A. and McGloin, R. and Pitfield, A.F. and Carr, R.R.

DOI: 10.4212/cjhp.v65i1.1098

The medical management of pediatric arrhythmias

Current Treatment Options in Cardiovascular Medicine

Escudero, C. and Carr, R. and Sanatani, S.

DOI: 10.1007/s11936-012-0194-5

Identification by families of pediatric adverse events and near misses overlooked by health care providers

CMAJ

Daniels, J.P. and Hunc, K. and Cochrane, D.D. and Carr, R. and Shaw, N.T. and Taylor, A. and Heathcote, S. and Brant, R. and Lim, J. and Ansermino, J.M.

DOI: 10.1503/cmaj.110393

The need for better data about counterfeit drugs in developing countries: A proposed standard research methodology tested in Chennai, India

Journal of Clinical Pharmacy and Therapeutics

Seear, M. and Gandhi, D. and Carr, R. and Dayal, A. and Raghavan, D. and Sharma, N.

DOI: 10.1111/j.1365-2710.2010.01198.x

Safety and pharmacokinetics of ribavirin for the treatment of la crosse encephalitis

Pediatric Infectious Disease Journal

McJunkin, J.E. and Nahata, M.C. and De Los Reyes, E.C. and Hunt, W.G. and Caceres, M. and Khan, R.R. and Chebib, M.G. and Taravath, S. and Minnich, L.L. and Carr, R. and Welch, C.A. and Whitley, R.J.

DOI: 10.1097/INF.0b013e31821c922c

Describing intravenous extravasation in children (DIVE study)

Canadian Journal of Hospital Pharmacy

Paquette, V. and McGloin, R. and Northway, T. and DeZorzi, P. and Singh, A. and Carr, R.

DOI: 10.4212/cjhp.v64i5.1069

Pharmacokinetics and drug dosing in obese children

Journal of Pediatric Pharmacology and Therapeutics

Kendrick, J. G., Carr, R. R., & Ensom, M. H. H. (2010). Pharmacokinetics and Drug Dosing in Obese Children. The Journal of Pediatric Pharmacology and Therapeutics: JPPT, 15(2), 94"109.

05 / 2010

A human factors and survey methodology-based design of a web-based adverse event reporting system for families

International Journal of Medical Informatics

Daniels, J.P. and King, A.D. and Cochrane, D.D. and Carr, R. and Shaw, N.T. and Lim, J. and Ansermino, J.M.

DOI: 10.1016/j.ijmedinf.2010.01.016

Comparison of continuous and intermittent IV infusion of vancomycin: Systematic review

Canadian Journal of Hospital Pharmacy

Man, S.S.K. and Carr, R.R. and Ensom, M.H.H.

DOI: 10.4212/cjhp.v63i5.949

Prevalence of Vitamin D Deficiency and Insufficiency in Children With Osteopenia or Osteoporosis Referred to a Pediatric Metabolic Bone Clinic

PEDIATRICS

S. A. Bowden and R. F. Robinson and R. Carr and J. D. Mahan

DOI: 10.1542/peds.2007-2111

06 / 2008

Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders

Journal of Pineal Research

Roxanne Carr and Michael B. Wasdell and Donald Hamilton and Margaret D. Weiss and Roger D. Freeman and Joseph Tai and Wop J. Rietveld and James E. Jan

DOI: 10.1111/j.1600-079x.2007.00485.x

11 / 2007

Complementary and alternative medicine for upper-respiratory-tract infection in children

American Journal of Health-System Pharmacy

Carr, R.R. and Nahata, M.C.

DOI: 10.2146/ajhp040613

Azithromycin for improving pulmonary function in cystic fibrosis

Annals of Pharmacotherapy

Carr, R.R. and Nahata, M.C.

DOI: 10.1345/aph.1D589

Drug Disposition and Therapy in Adolescence: The Effects of Puberty

The Journal of Pediatric Pharmacology and Therapeutics

Roxane R. Carr and Mary H.H. Ensom

DOI: 10.5863/1551-6776-8.2.86

04 / 2003

Fluoxetine in the Treatment of Premenstrual Dysphoric Disorder

Annals of Pharmacotherapy

Roxane R Carr and Mary HH Ensom

DOI: 10.1345/aph.1a265

04 / 2002

Octreotide for sulfonylurea-induced hypoglycemia following overdose

Annals of Pharmacotherapy

Carr, R. and Zed, P.J.

DOI: 10.1345/aph.1C076

Paralysis in the critically ill: Intermittent bolus pancuronium compared with continuous infusion

Critical Care Medicine

De Lemos, J.M. and Carr, R.R. and Shalansky, K.F. and Bevan, D.R. and Ronco, J.J.

DOI: 10.1097/00003246-199912000-00007

Primary induction with mycophenolate mofetil and corticosteroids in a liver transplant recipient with hepatorenal syndrome

Annals of Pharmacotherapy

Carr, R.R. and Yoshida, E.M. and Chung, S.W. and Partovi, N.

DOI: 10.1345/aph.17059

Review of Pharmacokinetics of Medications in Children Undergoing Therapeutic Plasma Exchange

Therapeutic Plasma Exchange (TPE), also known as plasmapharesis or “plex”, is a process that separates plasma for the cellular components of blood, discarding the plasma and exchanging it with replacement physiologic fluids such as albumin or fresh frozen plasma. TPE is used in the management of many types of conditions, including (but not limited to) systemic lupus erythema, thrombotic thrombocytopenic purpura (TTP), myasthenia gravis, severe septic shock, antiphospholipid antibody syndrome (APS), and Guillain Barre syndrome. By virtue of its nature, TPE extracts medications from plasma and potentially affects drug disposition and clearance. However, the degree and impact on the impact of TPE on pharmacokinetics is not well described and currently available literature is limited to case reports with highly variable parameters reported. This makes optimal dosing of key medications (especially antibiotics, sedative and anti-seizure medications) during and around TPE difficult to predict. Objectives: To describe the impact of TPE on serum drug concentrations of phenytoin, phenobarbital, vancomycin, gentamicin, and valproic acid. To describe optimal dosing around TPE to maintain target drug serum concentrations.

Correlation of limited sampling strategy for mycophenolate in pediatric solid organ transplant patients

Mycophenolate is commonly used as an immunosuppressant in children who have received solid organ transplants to prevent rejection of the graft. Currently therapeutic drug monitoring is recommended as dosage and serum concentration do not correlate well however it is unclear from the literature what the upper limit of the therapeutic range should be and if limited sampling strategies to estimate area under the curve correlates to effectiveness and adverse drug reactions. Objective: To describe the correlation between limited sampling strategy for mycophenolate and clinical effectiveness (adverse drug reactions and signs or organ graft rejection)

The Feasibility of Patient and Caregiver Self-Referral to Clinical Pharmacists in the Inpatient Pediatric Setting

Pharmacists play a significant role in patient care, part of which involves direct interaction with patients and caregivers. During hospitalization, many patients and caregivers may be unaware that a pharmacist is part of their team. In a previous study at our site, we found that only 10% of caregivers recalled speaking with a pharmacist; however 86% of caregivers indicated that they would like to speak with a pharmacist.1 Patients and caregivers may be unaware of how to contact their pharmacist during hospitalization, since they do not have the same direct access to their pharmacist as they would in other settings. Objective: To assess the feasibility of a patient/caregiver self-referral service to pharmacists

Honours & Awards

2012/2013 Pharmacotherapy Best Practices Award, Canadian Society of Hospital Pharmacists. Carney L, Kendrick J, Carr RR. Safety and Effectiveness of Dexmedetomidine in the Pediatric Intensive Care Unit (SAD–PICU)

2015/2016 Pharmacotherapy Best Practices Award, Canadian Society of Hospital Pharmacists. Collins K, Ensom MHH, Rainkie D, Carr RR. Pediatric assessment of vancomycin empiric dosing 2 (PAVED2).

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Stay in the Know

Sign up for compelling stories about innovative science, the doctors and researchers who turn ideas into discoveries and treatments, and the kids and families whose lives are changed.

This field is for validation purposes and should be left unchanged.