Yvonne Lamers

PhD

Investigator, BC Children's Hospital
Canada Research Chair in Human Nutrition and Vitamin Metabolism

My research interests relate to underlying mechanisms of nutrition and disease risk. I am eager to contribute to targeted and population-based prevention strategies of chronic diseases. My research specifically focuses on B-vitamins and their functions in human metabolism. B-vitamins are essential nutrients for normal cell growth and the nervous system and thus have an impact on human health from the embryo to the older adult. Low folate and/or vitamin B-12 status may yield pregnancy complications, low birth weight, and cognitive impairment.

The overarching theme of my research is nutrient adequacy. My current research projects focus on maternal-fetal nutrient dependency, periconceptional vitamin adequacy, and the role of maternal and infant nutrition on growth and development. In the UBC Nutritional Biomarker Laboratory that I established, my team has set up a wide array of externally validated analytical methods. One of our goals is to identify sensitive nutritional biomarkers for early diagnosis of micronutrient inadequacies. With the use of stable-isotope-tracer-protocols, we are able to investigate metabolic and functional consequences of nutrient inadequacies and imbalances. The studies help evaluate optimal vitamin intake to maintain biochemical functions. I am specifically interested in the metabolic effects of folic acid and less than optimal vitamin B-12 intake.

Academic Affiliations

  • Associate Professor, Human Nutrition, Department of Food, Nutrition, and Health, Faculty of Land and Food Systems, University of British Columbia
  • Research Theme: Healthy Starts
  • Research Group(s): Global Health and Innovations; Origins of Child Health and Disease

Contact Information

Location

950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4

Multiomics profiling and parenteral nutrition weaning in pediatric patients with intestinal failure: A longitudinal cohort study

Journal of Parenteral and Enteral Nutrition

Tappauf, N. and Lamers, Y. and Sham, H.P. and Piper, H.G.

DOI: 10.1002/jpen.2742

Paving the way for improved action: how nuclear techniques can advance the assessment of malnutrition

American Journal of Clinical Nutrition

Shertukde, S.P. and Padmanabha, R. and Chung, S.T. and Gaudichon, C. and Jones, K.S. and Kelly, P. and Krebs, N.F. and Kurpad, A. and Lamers, Y. and Lopez-Teros, V. and Melse-Boonstra, A. and Pereira, F.C. and Prado, C.M. and Roberts, S.B. and Shepherd, J. and Winichagoon, P. and Wells, J.C.K. and Loechl, C.U. and Hoffman, D.J.

DOI: 10.1016/j.ajcnut.2025.06.003

Exploring the Health Research Priorities of the South Asian Community in British Columbia

Progress in Community Health Partnerships Research Education and Action

Sidhu, A. and Singh, S. and Battersby, L. and Puri, N. and Condin, C. and Newman, M. and Nagra, R. and Bains, D. and Garg, A. and Shah, S. and Bajwa, L. and Jassar, S. and Lamers, Y.

DOI: 10.1353/CPR.2025.A956596

Nutrition biomarker assessment and exploration of the role of country foods to improve food security in the Saht Region, Canada

International Journal of Circumpolar Health

Ratelle, M. and Phillipps, B. and Skinner, K. and Lamers, Y. and Melo, L. and Laird, B. and Andrew, L. and Yakeleya, J. and Bougie, A. and Jensen, K. and Simmons, D.

DOI: 10.1080/22423982.2024.2438434

Is the Generation of Active Vitamin B6 Dependent upon Riboflavin Status? New Analysis of Data from RCTs of Riboflavin Supplementation

Proceedings

Ryan Barlow and Helene McNulty and Catherine Hughes and Kristina Pentieva and Geraldine Horigan and Yvonne Lamers and Mary Ward

DOI: 10.3390/proceedings2023091436

08 / 2024

Exploring the parity paradox: Differential effects on neuroplasticity and inflammation by APOEe4 genotype at middle age

Brain, Behavior, and Immunity

Lee, B.H. and Cevizci, M. and Lieblich, S.E. and Ibrahim, M. and Wen, Y. and Eid, R.S. and Lamers, Y. and Duarte-Guterman, P. and Galea, L.A.M.

DOI: 10.1016/j.bbi.2024.05.019

Maternal Iron and Vitamin D Status during the Second Trimester Is Associated with Third Trimester Depression Symptoms among Pregnant Participants in the APrON Cohort

Journal of Nutrition

Evanchuk, J.L. and Kozyrskyj, A. and Vaghef-Mehrabani, E. and Lamers, Y. and Giesbrecht, G.F. and Letourneau, N. and Aghajafari, F. and Dewey, D. and Leung, B. and Bell, R.C. and Field, C.J.

DOI: 10.1016/j.tjnut.2023.10.029

Early Pregnancy Folic Acid Supplement Use and Folate Status in the Alberta Pregnancy Outcomes and Nutrition (APrON) Study

Proceedings

Amy Tan and Maria F. Mujica-Coopman and Nicole Letourneau and Deborah Dewey and Gerald Giesbrecht and Catherine Field and Yvonne Lamers

DOI: 10.3390/proceedings2023091100

12 / 2023

Epigenetic effects of folate and related B vitamins on brain health throughout life: Scientific substantiation and translation of the evidence for health improvement strategies

Nutrition Bulletin

Caffrey, A. and Lamers, Y. and Murphy, M.M. and Letourneau, N. and Irwin, R.E. and Pentieva, K. and Ward, M. and Tan, A. and Rojas-G{\'o}mez, A. and Santos-Calder{\'o}n, L.A. and Canals-Sans, J. and Leung, B.M.Y. and Bell, R. and Giesbrecht, G.F. and Dewey, D. and Field, C.J. and Kobor, M. and Walsh, C.P. and McNulty, H.

DOI: 10.1111/nbu.12611

Exploring the parity paradox: Differential effects on neuroplasticity and neuroinflammation by APOEe4 genotype at middle-age

bioRxiv

Lee, B.H. and Cevizci, M. and Lieblich, S.E. and Ibrahim, M. and Wen, Y. and Eid, R.S. and Lamers, Y. and Duarte-Guterman, P. and Galea, L.A.M.

DOI: 10.1101/2023.07.12.548731

Long-term cellular and molecular signatures of pregnancy in the adult and ageing brain

bioRxiv

Duarte-Guterman, P. and Richard, J.E. and Lieblich, S.E. and Eid, R.S. and Lamers, Y. and Galea, L.A.M.

DOI: 10.1101/2023.02.24.529879

Cellular and molecular signatures of motherhood in the adult and ageing rat brain

Open Biology

Duarte-Guterman, P. and Richard, J.E. and Lieblich, S.E. and Eid, R.S. and Lamers, Y. and Galea, L.A.M.

DOI: 10.1098/rsob.230217

Vitamin B-12 Requirements in Older Adults"Increasing Evidence Substantiates the Need To Re-Evaluate Recommended Amounts and Dietary Sources

The Journal of Nutrition

Yvonne Lamers

DOI: 10.1093/jn/nxac179

11 / 2022

Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms

Clinical Epigenetics

Ondi?ov{\'a}, M. and Irwin, R.E. and Thursby, S.-J. and Hilman, L. and Caffrey, A. and Cassidy, T. and McLaughlin, M. and Lees-Murdock, D.J. and Ward, M. and Murphy, M. and Lamers, Y. and Pentieva, K. and McNulty, H. and Walsh, C.P.

DOI: 10.1186/s13148-022-01282-y

Vitamin B-6 and riboflavin, their metabolic interaction, and relationship with MTHFR genotype in adults aged 18"102 years

American Journal of Clinical Nutrition

Jarrett, H. and McNulty, H. and Hughes, C.F. and Pentieva, K. and Strain, J.J. and McCann, A. and McAnena, L. and Cunningham, C. and Molloy, A.M. and Flynn, A. and Hopkins, S.M. and Horigan, G. and O'Connor, C. and Walton, J. and McNulty, B.A. and Gibney, M.J. and Lamers, Y. and Ward, M.

DOI: 10.1093/ajcn/nqac240

Impact of high-dose folic acid supplementation in pregnancy on biomarkers of folate status and 1-carbon metabolism: An ancillary study of the Folic Acid Clinical Trial (FACT)

The American Journal of Clinical Nutrition

Malia SQ Murphy and Katherine A Muldoon and Hauna Sheyholislami and Nathalie Behan and Yvonne Lamers and Natalie Rybak and Ruth Rennicks White and Alysha LJ Harvey and Laura M Gaudet and Graeme N Smith and Mark C Walker and Shi Wu Wen and Amanda J MacFarlane

DOI: 10.1093/ajcn/nqaa407

05 / 2021

Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams

bioRxiv

Qiu, W. and Go, K.A. and Lamers, Y. and Galea, L.A.M.

DOI: 10.1101/2021.02.11.430473

Maternal vitamin B 12 status in early pregnancy and its association with birth outcomes in Canadian mother-newborn Dyads

British Journal of Nutrition

Tan, A. and Sinclair, G. and Mattman, A. and Vallance, H.D. and Lamers, Y.

DOI: 10.1017/S0007114521000581

Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease

Frontiers in Nutrition

Williams, B.A. and Mayer, C. and McCartney, H. and Devlin, A.M. and Lamers, Y. and Vercauteren, S.M. and Wu, J.K. and Karakochuk, C.D.

DOI: 10.3389/fnut.2021.642306

Maternal plasma folate concentration is positively associated with serum total cholesterol and low-density lipoprotein across the three trimesters of pregnancy.

Scientific reports

da Silva MT and Mujica-Coopman MF and Figueiredo ACC and Hampel D and Vieira LS and Farias DR and Shahab-Ferdows S and Allen LH and Brito A and Lamers Y and Kac G and S Vaz J

DOI: 10.1038/s41598-020-77231-7 PubMed: 33214613

11 / 2020

Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop.

The American journal of clinical nutrition

Maruvada P and Stover PJ and Mason JB and Bailey RL and Davis CD and Field MS and Finnell RH and Garza C and Green R and Gueant JL and Jacques PF and Klurfeld DM and Lamers Y and Zappal G

DOI: 10.1093/ajcn/nqaa259 PubMed: 33022704

11 / 2020

Development of novel Vitamin B12 fortified yogurts using isolated and microencapsulated Vitamin B12

Proceedings of the Nutrition Society

Larisse Melo and Clementine Ng and Ricky Tsang and Anubhav Pratap Singh and David Kitts and Yvonne Lamers

DOI: 10.1017/s0029665120002128

06 / 2020

Plasma riboflavin concentration as novel indicator for vitamin-B2 status assessment: suggested cutoffs and its association with vitamin-B6 status in women

Proceedings of the Nutrition Society

Amy Tan and Mohammad Zubair and Chia-ling Ho and Liadhan McAnena and Helene McNulty and Mary Ward and Yvonne Lamers

DOI: 10.1017/s0029665120006072

06 / 2020

Plasma Free Choline Concentration Did Not Reflect Dietary Choline Intake in Early and Late Pregnancy: Findings from the APrON Study.

Current developments in nutrition

Mujica M and Lewis E and Jacobs R and Letourneau N and Bell R and Field C and Lamers Y

05 / 2020

Plasma Choline Concentration Is Positively Correlated with Visual Acuity in 18-Month Old Toddlers: Preliminary Findings.

Current developments in nutrition

Montgomery S and Rossen L and Zibrik D and Dyer R and Oberlander T and Lamers Y

05 / 2020

Nutritional Status in Breastfed 18-Month Old Toddlers: Cross-Sectional Findings.

Current developments in nutrition

Montgomery S and Ho G and Rossen L and Zibrik D and Dyer R and Oberlander T and Lamers Y

05 / 2020

Vitamin B-12 Biomarkers Reviewed: Holotranscobalamin Allows Identification of Vitamin B12 Deficiency in Children with Short-Bowel Syndrome.

Current developments in nutrition

St-Cyr C and Lamers Y and Casey L and Saunders M and Sinclair G and Mattman A

05 / 2020

Detectable Unmetabolized Folic Acid, and Sufficient Folate and Vitamin B12 Concentrations Are Evident in Canadian Children with Sickle Cell Disease.

Current developments in nutrition

Williams B and McCartney H and Lamers Y and Vercauteren S and Wu J and Karakochuk C

05 / 2020

Blood DHA, Choline, and Lutein Concentrations and Their Correlation with Cognitive and Behavioral Outcomes in 18-Month Old Toddlers: Preliminary Findings.

Current developments in nutrition

Rossen L and Montgomery S and Zibrik D and Dyer R and Oberlander T and Lamers Y

05 / 2020

Postpartum fluoxetine increases maternal hippocampal IL-1 and decreased plasma tryptophan: clues for efficacy

Qiu W and Duarte-Guterman P and Eid RS and Go KA and Lamers Y and Galea LAM

DOI: 10.1101/2020.02.22.960021

02 / 2020

Is folate deficiency a common cause of distal symmetric polyneuropathy in Zambian clinics?

Journal of the Neurological Sciences

Kvalsund, M. and Kayamba, V. and Kelly, P. and Birbeck, G.L. and Mwansa-Thurman, C. and Sommer, I.N. and Lamers, Y. and Gardiner, J. and Herrmann, D.N.

DOI: 10.1016/j.jns.2019.116583

Maternal and cord blood folate concentrations are inversely associated with fetal DNA hydroxymethylation, but not DNA methylation, in a cohort of pregnant Canadian women

Journal of Nutrition

Plumptre, L. and Tammen, S.A. and Sohn, K.-J. and Masih, S.P. and Visentin, C.E. and Aufreiter, S. and Malysheva, O. and Schroder, T.H. and Ly, A. and Berger, H. and Croxford, R. and Lamers, Y. and Caudill, M.A. and Choi, S.-W. and O'Connor, D.L. and Kim, Y.-I.

DOI: 10.1093/jn/nxz232

Postpartum fluoxetine increased maternal inflammatory signalling and decreased tryptophan metabolism: Clues for efficacy

Neuropharmacology

Qiu, W. and Duarte-Guterman, P. and Eid, R.S. and Go, K.A. and Lamers, Y. and Galea, L.A.M.

DOI: 10.1016/j.neuropharm.2020.108174

Micronutrient intakes of lactating mothers and their association with breast milk concentrations and micronutrient adequacy of exclusively breastfed Indonesian infants

The American Journal of Clinical Nutrition

DOI: 10.1093/ajcn/nqz047

08 / 2019

Maternal Plasma Pyridoxal 5'-Phosphate Concentration Is Inversely Associated with Plasma Cystathionine Concentration across All Trimesters in Healthy Pregnant Women

The Journal of Nutrition

DOI: 10.1093/jn/nxz082

08 / 2019

Reference intervals for serum total vitamin B12 and holotranscobalamin concentrations and their change points with methylmalonic acid concentration to assess vitamin B12 status during early and mid-pregnancy

Clinical Chemistry and Laboratory Medicine (CCLM)

DOI: 10.1515/cclm-2018-1337

05 / 2019

Approaches to improving micronutrient status assessment at the population level

Proceedings of the Nutrition Society

Lamers, Y.

DOI: 10.1017/S0029665118002781

Variability of water-soluble forms of choline concentrations in human milk during storage, after pasteurization, and among women

Nutrients

Moukarzel, S. and Wiedeman, A.M. and Soberanes, L.S. and Dyer, R.A. and Innis, S.M. and Lamers, Y.

DOI: 10.3390/nu11123024

Associations between the level of trace elements and minerals and folate in maternal serum and amniotic fluid and congenital abnormalities

Nutrients

Kocylowski, R. and Grzesiak, M. and Gaj, Z. and Lorenc, W. and Bakinowska, E. and Bara?kiewicz, D. and von Kaisenberg, C.S. and Lamers, Y. and Suliburska, J.

DOI: 10.3390/nu11020328

Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor

Archives of Medical Science

Suliburska, J. and Kocy?owski, R. and Grzesiak, M. and Gaj, Z. and Chan, B. and Von Kaisenberg, C. and Lamers, Y.

DOI: 10.5114/aoms.2018.78776

Formate concentrations in maternal plasma during pregnancy and in cord blood in a cohort of pregnant Canadian women: Relations to genetic polymorphisms and plasma metabolites

American Journal of Clinical Nutrition

Brosnan, J.T. and Plumptre, L. and Brosnan, M.E. and Pongnopparat, T. and Masih, S.P. and Visentin, C.E. and Berger, H. and Lamers, Y. and Caudill, M.A. and Malysheva, O.V. and O'Connor, D.L. and Kim, Y.-I.

DOI: 10.1093/ajcn/nqz152

Serum Betaine and Dimethylglycine Are Higher in South Asian Compared with European Pregnant Women in Canada, with Betaine and Total Homocysteine Inversely Associated in Early and Midpregnancy, Independent of Ethnicity

Journal of Nutrition

Mujica-Coopman, M.F. and Tan, A. and Schroder, T.H. and Sinclair, G. and Vallance, H.D. and Lamers, Y.

DOI: 10.1093/jn/nxz178

Periconceptional intake of folic acid among low-risk women in Canada: Summary of a workshop aiming to align prenatal folic acid supplement composition with current expert guidelines

American Journal of Clinical Nutrition

Lamers, Y. and MacFarlane, A.J. and O'Connor, D.L. and Fontaine-Bisson, B.

DOI: 10.1093/ajcn/nqy212

Correlations between maternal, breast milk, and infant vitamin B12 concentrations among mother-infant dyads in Vancouver, Canada and Prey Veng, Cambodia: An exploratory analysis

Nutrients

Chebaya, P. and Karakochuk, C.D. and March, K.M. and Chen, N.N. and Stamm, R.A. and Kroeun, H. and Sophonneary, P. and Borath, M. and Shahab-Ferdows, S. and Hampel, D. and Barr, S.I. and Lamers, Y. and Houghton, L.A. and Allen, L.H. and Green, T.J. and Whitfield, K.C.

DOI: 10.3390/nu9030270

Barriers and facilitators to recruitment of South Asians to health research: A scoping review

BMJ Open

Quay, T.A.W. and Frimer, L. and Janssen, P.A. and Lamers, Y.

DOI: 10.1136/bmjopen-2016-014889

Vitamin B-6 status in unsupplemented pregnant women is associated positively with serum docosahexaenoic acid and inversely with the n-6-to-n-3 fatty acid ratio

Journal of Nutrition

Mujica-Coopman, M.F. and Franco-Sena, A.B. and Farias, D.R. and Vaz, J.S. and Brito, A. and Kac, G. and Lamers, Y.

DOI: 10.3945/jn.116.239483

Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B12 status compared with pregnant women of European ethnicity

British Journal of Nutrition

Schroder, T.H. and Sinclair, G. and Mattman, A. and Jung, B. and Barr, S.I. and Vallance, H.D. and Lamers, Y.

DOI: 10.1017/S0007114517002331

South asian ethnicity is related to the highest risk of vitamin b12 deficiency in pregnant canadian women

Nutrients

Jeruszka-Bielak, M. and Isman, C. and Schroder, T.H. and Li, W. and Green, T.J. and Lamers, Y.

DOI: 10.3390/nu9040317

Low serum vitamin B-12 concentrations are prevalent in a cohort of pregnant Canadian women

Journal of Nutrition

Visentin, C.E. and Masih, S.P. and Plumptre, L. and Schroder, T.H. and Sohn, K.-J. and Ly, A. and Lausman, A.Y. and Berger, H. and Croxford, R. and Lamers, Y. and Kim, Y.-I. and O'Connor, D.L.

DOI: 10.3945/jn.115.226845

Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age

Asia Pacific Journal of Clinical Nutrition

Cheong, M. and Xiao, H.Y. and Tay, V. and Karakochuk, C.D. and Liu, Y.A. and Harvey, S. and Lamers, Y. and Houghton, L.A. and Kitts, D.D. and Green, T.J.

DOI: 10.6133/apjcn.2016.25.1.08

Reference interval of methylmalonic acid concentrations in dried blood spots of healthy, term newborns to facilitate neonatal screening of vitamin B12 deficiency

Clinical Biochemistry

Schroder, T.H. and Mattman, A. and Sinclair, G. and Vallance, H.D. and Lamers, Y.

DOI: 10.1016/j.clinbiochem.2016.03.007

Prevalence and predictors of low vitamin B6 status in healthy young adult women in metro vancouver

Nutrients

Ho, C.-L. and Quay, T.A.W. and Devlin, A.M. and Lamers, Y.

DOI: 10.3390/nu8090538

High prevalence of suboptimal vitamin B12 status in young adult women of South Asian and European ethnicity

Applied Physiology Nutrition and Metabolism

Quay, T.A.W. and Schroder, T.H. and Jeruszka-Bielak, M. and Li, W. and Devlin, A.M. and Barr, S.I. and Lamers, Y.

DOI: 10.1139/apnm-2015-0200

Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey veng, Cambodia

Journal of Nutrition

Karakochuk, C.D. and Whitfield, K.C. and Barr, S.I. and Lamers, Y. and Devlin, A.M. and Vercauteren, S.M. and Kroeun, H. and Talukder, A. and McLean, J. and Green, T.J.

DOI: 10.3945/jn.114.198945

Methylmalonic acid quantified in dried blood spots provides a precise, valid, and stable measure of functional vitamin b-12 status in healthy women

Journal of Nutrition

Schroder, T.H. and Quay, T.A.W. and Lamers, Y.

DOI: 10.3945/jn.114.194829

Metabolomic Analysis Reveals Extended Metabolic Consequences of Marginal Vitamin B-6 Deficiency in Healthy Human Subjects

PLoS ONE

Gregory III, J.F. and Park, Y. and Lamers, Y. and Bandyopadhyay, N. and Chi, Y.-Y. and Lee, K. and Kim, S. and da Silva, V. and Hove, N. and Ranka, S. and Kahveci, T. and Muller, K.E. and Stevens, R.D. and Newgard, C.B. and Stacpoole, P.W. and Jones, D.P.

DOI: 10.1371/journal.pone.0063544

Red blood cell folate levels in pregnant women with a history of mood disorders: A case series

Birth Defects Research Part A - Clinical and Molecular Teratology

Yaremco, E. and Inglis, A. and Innis, S.M. and Hippman, C. and Carrion, P. and Lamers, Y. and Honer, W.G. and Austin, J.

DOI: 10.1002/bdra.23144

Metabolite profile analysis reveals functional effects of 28-day vitamin b-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthymen andwomen

Journal of Nutrition

da Silva, V.R. and Rios-Avila, L. and Lamers, Y. and Ralat, M.A. and Midttun, O. and Quinlivan, E.P. and Garrett, T.J. and Coats, B. and Shankar, M.N. and Percival, S.S. and Chi, Y.-Y. and Muller, K.E. and Ueland, P.M. and Stacpoole, P.W. and Gregory III, J.F.

DOI: 10.3945/jn.113.180588

Marginal vitamin B-6 deciency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women

Journal of Nutrition

Zhao, M. and Lamers, Y. and Ralat, M.A. and Coats, B.S. and Chi, Y.-Y. and Muller, K.E. and Bain, J.R. and Shankar, M.N. and Newgard, C.B. and Stacpoole, P.W. and Gregory III, J.F.

DOI: 10.3945/jn.112.163246

Global hypothesis testing for high-dimensional repeated measuresoutcomes

Statistics in Medicine

Chi, Y.-Y. and Gribbin, M. and Lamers, Y. and Gregory, J.F. and Muller, K.E.

DOI: 10.1002/sim.4435

Indicators and methods for folate, vitamin B-12, and vitamin B-6 status assessment in humans

Current Opinion in Clinical Nutrition and Metabolic Care

Lamers, Y.

DOI: 10.1097/MCO.0b013e328349f9a7

Folate recommendations for pregnancy, lactation, and infancy

Annals of Nutrition and Metabolism

Lamers, Y.

DOI: 10.1159/000332073

Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women

Journal of Nutrition

Lamers, Y. and Coats, B. and Ralat, M. and Quinlivan, E.P. and Stacpoole, P.W. and Gregory, J.F.

DOI: 10.3945/jn.110.134197

Kinetics of folate and one-carbon metabolism

Folate in Health and Disease, Second Edition

Gregory, J.F. and da Silva, V.R. and Lamers, Y.

Production of 1-carbon units from glycine is extensive in healthy men and women 1,2

Journal of Nutrition

Lamers, Y. and Williamson, J. and Theriaque, D.W. and Shuster, J.J. and Gilbert, L.R. and Keeling, C. and Stacpoole, P.W. and Gregory, J.F.

DOI: 10.3945/jn.108.103580

Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women

American Journal of Clinical Nutrition

Lamers, Y. and O'Rourke, B. and Gilbert, L.R. and Keeling, C. and Matthews, D.E. and Stacpoole, P.W. and Gregory III, J.F.

DOI: 10.3945/ajcn.2009.27747

Supplementation with a multivitamin containing 800 g of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women

International Journal for Vitamin and Nutrition Research

Brmswig, S. and Prinz-Langenohl, R. and Lamers, Y. and Tobolski, O. and Wintergerst, E. and Berthold, H.K. and Pietrzik, K.

DOI: 10.1024/0300-9831.79.2.61

Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women

Journal of Nutrition

Lamers, Y. and Williamson, J. and Ralat, M. and Quinlivan, E.P. and Gilbert, L.R. and Keeling, C. and Stevens, R.D. and Newgard, C.B. and Ueland, P.M. and Meyer, K. and Fredriksen, A. and Stacpoole, P.W. and Gregory III, J.F.

DOI: 10.3945/jn.108.099184

A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism

Journal of Nutrition

Nijhout, H.F. and Gregory, J.F. and Fitzpatrick, C. and Cho, E. and Lamers, K.Y. and Ulrich, C.M. and Reed, M.C.

DOI: 10.3945/jn.109.104265

Reply to EP Quinlivan

American Journal of Clinical Nutrition

Lamers, Y. and Pietrzik, K.

DOI: 10.1093/ajcn/87.5.1538

Glycine Turnover and Decarboxylation Rate Quantified in Healthy Men and Women Using Primed, Constant Infusions of [1,2-13C2]Glycine and [2H3]Leucine

The Journal of Nutrition

Yvonne Lamers and Jerry Williamson and Lesa R. Gilbert and Peter W. Stacpoole and Jesse F. Gregory

DOI: 10.1093/jn/137.12.2647

Calculation of red blood cell folate steady state conditions and elimination kinetics after daily supplementation with various folate forms and doses in women of childbearing age

American Journal of Clinical Nutrition

Pietrzik, K. and Lamers, Y. and Brmswig, S. and Prinz-Langenohl, R.

DOI: 10.1093/ajcn/86.5.1414

Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age

American Journal of Clinical Nutrition

Lamers, Y. and Prinz-Langenohl, R. and Brmswig, S. and Pietrzik, K.

DOI: 10.1093/ajcn/84.1.156

Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women

The American Journal of Clinical Nutrition

Yvonne Lamers and Reinhild Prinz-Langenohl and Rudolf Moser and Klaus Pietrzik

DOI: 10.1093/ajcn/79.3.473

03 / 2004

DERiVE: DEvelopment of Riboflavin biomarkers to relate dietary sources with status, gene-nutrient Interactions and Validated health Effects in adult cohorts (JPI-HDHL)

Vitamin B2 plays a crucial role in human development and health across the lifespan. Recently, an increase in vitamin B2 intake was suggested to having a reducing effect on blood pressure. In most countries, there is little or no knowledge about the vitamin B2 nutrition status of the population due to the lack of convenient blood indicators and assessment tools. Dietary records are the sole source of information for most countries; however these do not reflect the biochemical status of the population which is a better indicator of health effects. In this international and multidisciplinary project, we aim to develop accessible blood indicators for vitamin B2 status assessment and identify which most sensitively reflect dietary intakes and food sources of vitamin B2 in Irish and Canadian adults. We will also demonstrate an important health effect of vitamin B2 by investigating its role in modulating blood pressure via a novel gene-nutrient interactive effect. In summary, sub-optimal vitamin B2 status may be more widespread than is generally recognized across the developed world, because of the reliance on dietary data only in nutrition surveys, without blood indicator evidence. This project will address this gap by developing accessible vitamin B2 blood indicators for use in population surveys globally, and by demonstrating important functional, gene-nutrient and health effects of optimal vitamin B2 status in Canadian, Irish and UK cohorts.

JPI-HDHL Call "Biomarkers in Nutrition and Health;" CIHR Team Grant (PI: Yvonne Lamers)

Webpage: www.derive-riboflavin.com

Epigenetic Effects of B Vitamins on Brain Health Throughout Life

B vitamins play an important role in brain development and function. Not only have previous studies observed an association between maternal folate status during pregnancy and cognitive performance in offspring, but optimal folate and related B-vitamin status may also prevent cognitive decline in later life. Epigenetics, which involves modifications to DNA without affecting the sequence, can influence gene expression and may be a possible mechanism linking B vitamins and brain outcomes. The EpiBrain project, a collaboration among research teams in Canada, United Kingdom and Spain, aims to investigate the nutrition-epigenome-brain relationship across the lifespan in hopes of improved understanding of the role of B vitamins, their effects on the epigenome and brain function in childhood and older age.

JPI-HDHL Call "Nutrition & the Epigenome;" CIHR Team Grant (Lead PI: Yvonne Lamers)
BCCHR Co-Investigator: Dr. Michael Kobor, Investigator at the Centre for Molecular Medicine and Therapeutics
International Co-Principal Investigators: Dr. Nicole Letourneau (University of Calgary), Dr. Helene McNulty (Ulster University, Northern Ireland), Dr. Michelle Murphy (Universitat Rovira i Virgili)

Vitamins in Pregnancy and Infancy – Defining Adequacy for Maternal and Child Health

Early development during pregnancy and infancy, also described as the first 1000 days of life, is characterized by rapid growth and increased nutrient demands. Low vitamin status during this critical time period can impair fetal and infant growth and development, and predispose the child to potential long-term health consequences.

Maternal vitamin B12 status during pregnancy has been described to have a long-term impact on neonatal and infant vitamin B12 status. Vitamin B12, as well as folate, vitamin B6, and riboflavin, play key roles in the one-carbon metabolism crucial for DNA synthesis and methylation. Our research focuses on defining sensitive biomarkers of B-vitamin status in various stages of pregnancy and their association with infant vitamin status and growth indicators.

This project is in collaboration with Dr. Hilary Vallance, Director of the Newborn Screening Program in B.C. and Yukon, Dr. Graham Sinclair, Biochemical Geneticist, BC Newborn Screening Program at BC Children’s Hospital and Dr. Andre Mattman, Medical Biochemist at St. Paul’s Hospital.

Newborn Screening as an Opportunity to Monitor for Nutritional Vitamin Deficiencies

Vitamin B12 deficiency in the infant develops in the first year of life and can lead to developmental delays. Screening for vitamin B12 deficiency is generally done by measuring serum (or plasma) total vitamin B12 concentrations. We recently developed a novel method for quantification of methylmalonic acid (MMA) in dried blood spots (DBS), which allows convenient and minimally invasive assessment of functional vitamin B12 status. The method is 10-fold more sensitive than currently existing screening test and able to quantify DBS MMA in ranges of vitamin B12 deficiency secondary to maternal deficiency. We estimated a reference interval for DBS MMA concentrations in healthy, term newborns (https://pubmed.ncbi.nlm.nih.gov/27040901/). In light of the detrimental and potentially irreversible consequences of vitamin B12 deficiency, early diagnosis is crucial and ideally established for all newborns.

Derivation of Early Indicators for Diagnosis and Treatment of Vitamin B12 Deficiency in Children

Vitamin B12 deficiency in early childhood can result in severe and permanent adverse health consequences; however, there is a lack of an accurate tool for vitamin B12 deficiency diagnosis in children. Blood vitamin B12 levels are evaluated against adult normal values, yet early consequences may occur before blood levels appear to be “abnormal”. Our research team recently developed a new method to measure a more sensitive marker of vitamin B12 deficiency. By comparing the new method with clinical vitamin B12 testing in blood of at-risk children, we aim to define levels of vitamin B12 deficiency that warrant early treatment.

Co-Principal Investigator: Dr. Linda Casey, Director of the BC Children’s Hospital Intestinal Rehabilitation Program (CHIRP).

Riboflavin and Vitamin B6 Status in Young and Older Adult Women

Vitamin B6 is essential to mount an adequate immune response and to maintain a healthy nervous system. Although research shows that dietary intake of vitamin B6 among Canadians is low, no clear data exists as to whether Canadians are living with suboptimal or deficient biochemical vitamin B6 status. Suboptimal vitamin B6 status has been linked to cardiovascular diseases, stroke, and cancer. Specifically, there is a higher risk of developing ovarian cancer and breast cancer, which puts women into special focus.

In two cross-sectional studies, we determined the prevalence and determinants of vitamin B6 deficiency and suboptimal vitamin B6 status in young adult women (aged 19-35 years) and older adult women (aged 51-70 years). We found a 12% prevalence (https://www.mdpi.com/2072-6643/8/9/538) of low vitamin B6 status in young adult women. Further, we identified relative dietary vitamin B6 intake and the use of vitamin B6 containing supplements to be positive predictors, and body mass index and South Asian ethnicity to be negative predictors of vitamin B6 status. The data on older adult women are currently being evaluated.

Functional Consequences of Suboptimal B-Vitamin Status

A mounting number of epidemiologic studies have shown that suboptimal vitamin status, the ‘grey zone’ between adequacy and deficiency, is associated with a higher risk of chronic diseases. Suboptimal vitamin B12 status for example has been associated with an increased risk of adverse pregnancy outcomes such as spina bifida, and faster cognitive decline in older adults. Suboptimal vitamin B6 status has been linked with cardiovascular diseases and cancer. We are interested in contributing to the understanding of the underlying mechanisms between inadequacy and disease development by studying the biochemical alterations in stages of suboptimal vitamin status using stable isotope tracer protocols. Our research will contribute to the understanding of the metabolic and physiologic consequences of suboptimal B-vitamin status and B-vitamin imbalance.

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