Ted Steiner

MD

Investigator, BC Children's Hospital
Head, Division of Infectious Diseases, University of British Columbia

The human gut is a very complex system that affects many areas of health. For the gut to work normally, there must be coordination between the immune system, nervous system, and multiple different cell types that line the gut and help it to process and absorb food while fighting infections. The gut also carries a huge number of microbes that play important roles in maintaining its functions. My work focuses on the way that the intestinal immune system functions to fight infections while maintaining normal relationships with the "good" bacteria that normally live in the gut.

Academic Affiliations

  • Professor, Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases
  • Research Group(s): Immunity in Health and Disease; Vaccines, Infections, and Host Defenses

Contact Information

Location

950 West 28th Ave, Vancouver, BC, Canada, V5Z 4H4

PUNCH CD3-OLS: A Phase 3 Prospective Observational Cohort Study to Evaluate the Safety and Efficacy of Fecal Microbiota, Live-jslm (REBYOTA) in Adults With Recurrent Clostridioides difficile Infection

Clinical Infectious Diseases

Feuerstadt, P. and Chopra, T. and Knapple, W. and Van Hise, N.W. and Dubberke, E.R. and Baggott, B. and Guthmueller, B. and Bancke, L. and Gamborg, M. and Steiner, T.S. and Van Handel, D. and Khanna, S.

DOI: 10.1093/cid/ciae437

Effects of Lyophilized Fecal Filtrate Compared with Lyophilized Donor Stool for Preventing Recurrent Clostridioides Difficile Infection: A Multi-Center, Randomized, Double-Blinded Trial

Ssrn

Kao, D. and Wong, K. and Lee, C. and Steiner, T. and Franz, R. and McDougall, C. and Silva, M. and Schmidt, T. and Walter, J. and Loebenberg, R. and Monaghan, T.M. and Giebelhaus, R. and Harynuk, J.J. and Xu, H. and Yaskina, M. and MacDonald, K.V. and Marshall, D.A. and Louie, T.

DOI: 10.2139/ssrn.5216159

Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein

Nature Communications

Mannar, D. and Saville, J.W. and Poloni, C. and Zhu, X. and Bezeruk, A. and Tidey, K. and Ahmed, S. and Tuttle, K.S. and Vahdatihassani, F. and Cholak, S. and Cook, L. and Steiner, T.S. and Subramaniam, S.

DOI: 10.1038/s41467-024-46104-2

Adaptive immune responses to two-dose COVID-19 vaccine series in healthy Canadian adults = 50years: a prospective, observational cohort study

Scientific Reports

Gaultier, G.N. and McMillan, B. and Poloni, C. and Lo, M. and Cai, B. and Zheng, J.J. and Baer, H.M. and Shulha, H.P. and Simmons, K. and Mrquez, A.C. and Bartlett, S.R. and Cook, L. and Levings, M.K. and Steiner, T. and Sekirov, I. and Zlosnik, J.E.A. and Morshed, M. and Skowronski, D.M. and Krajden, M. and Jassem, A.N. and Sadarangani, M.

DOI: 10.1038/s41598-024-59535-0

Dysregulated Immunity to Clostridioides difficile in IBD Patients Without a History of Recognized Infection

Inflammatory Bowel Diseases

Cook, L. and Wong, M.Q. and Rees, W.D. and Schick, A. and Lisko, D.J. and Lunken, G.R. and Wang, X. and Peters, H. and Oliveira, L. and Lau, T. and Mah, R. and Bressler, B. and Levings, M.K. and Steiner, T.S.

DOI: 10.1093/ibd/izad238

Integrated Safety and Efficacy Analyses of Phase3 Trials of a Microbiome Therapeutic for Recurrent CDI

Infectious Diseases and Therapy

Kraft, C.S. and Sims, M. and Silverman, M. and Louie, T.J. and Feuerstadt, P. and Huang, E.S. and Khanna, S. and Berenson, C.S. and Wang, E.E.L. and Cohen, S.H. and Korman, L. and Lee, C. and Kelly, C.R. and Odio, A. and Cook, P.P. and Lashner, B. and Ramesh, M. and Kumar, P. and De, A. and Memisoglu, A. and Lombardi, D.A. and Hasson, B.R. and McGovern, B.H. and von Moltke, L. and Pardi, D.S. and Rozen, S.E. and Tiongco, F.P. and Patel, D. and Salvato, P. and Zahedi, M. and Bochan, M.R. and Joseph, J.M. and Rehman, S.M. and Sarol, J. and Parikh, N. and Hong, J. and Clark, L.E. and El-Nachef, N. and Yen, E.F. and Maher, J.A. and Preiksaitis, H.G. and Adeyafa, B. and Gorrela, S.V. and Nauako, K.W. and Doshi, A.A. and Fernandez, R. and Daccak, R. and Dickstein, G. and Tyagi, V. and Kuliev, A. and Cubillas, M. and Gonzales, C.M. and Arif, A.A. and Trevino, M.E. and Gonzalez-Rojas, Y. and Sarles, H. and Godofsky, E. and Bekal, P.K. and Zafar, Z.N. and Musgrave, B. and Carbonneau, D. and De Beixedon, J. and Skuraba, A. and Valle, E. and Dulitz, D. and Choi, M. and Ellerin, T.B. and Singaram, C. and Boren, K. and Rai, S. and Wilson, J. and Gentry, A. and Coates, A.G. and Brennan, R. and Powell, D. and Rao, S. and Terrelonge, A. and Gupta, A. and Alfonso, T. and Tabbaa, M. and Patel, S. and Lohani, G. and Husain, S.N. and Hanabergh, R. and Branin, B. and Dar, S. and Gebhard, R. and Jamal, M.M. and Parker, M. and Hendrix, E. and Curran, J. and Beshay, M. and Thanawala, R. and Jaeger, R. and Galambos, M. and Jazrawi, S. and Orr, R. and Bangash, I. and Kogan, M. and Hadi, G. and Vincent, J. and Mason, R. and Kumar, S. and Katikaneni, S. and Llana, A.D. and Henry, P. and Higgins, P. and Black, R. and Parekh, R. and Okolo, C. and Sherman, A. and Welker, J. and Welton, T. and Garber, J. and Behm, B. and Flores, L. and Haaksma, J. and Mehmood, T. and Hecht, G. and Hall, M. and Bacon, A. and Stern, J. and Osiyemi, O. and Moya, J. and Gill, S. and Friedenberg, K. and Stanciu, S. and Gumber, S. and Caradonna, R. and Naqvi, S. and Coppola, A. and Tan, M. and Ephtimios, I. and Kayali, Z. and Oubre, B. and Houghton, J. and Barish, C. and Golan, Y. and Gancayco, J. and Wofford, S. and Portnoy, E. and Kim, S. and Johnson, K. and Onwueme, K. and Bullock, J. and Stock, K. and Phillips, R. and Degala, G. and Schmalz, M. and Rutland, T. and Hussain, A. and Surace, L. and Ruthardt, F. and Brook, L. and Sepe, P. and Ramesh, G. and Pinero, J. and Oguchi, G. and Ayub, K. and Benjamin, S. and Talreja, N. and Jamal, A. and DuPont, H. and Abbas, J. and Diaz, J. and Newton, E. and Nadar, V. and Bressler, A. and Pedersen, P. and Gutierrez, J.C.M. and Fogel, R. and Bennett, M. and Berman, L. and Kreines, M. and Weinstock, L. and Guimont, C. and Gauthier, S. and Daley, P. and Butt, D. and Steiner, T. and Grimard, D. and Bogdanovich, T. and Heuer, M. and Shapiro, M. and Arsenescu, R. and Walton, M. and Adams, A. and Hernandez, L. and Patel, M. and Colman, R. and Baird, I.M. and Ritter, T. and Esfandyari, T. and O?Marro, S. and Andrade, G. and Arimie, C. and Garcia-Diaz, J. and Sheikh, A. and Georgetson, M. and Hansen, V. and Smith, K. and Tran, H. and Acosta, I. and Williams, J. and Pullman, J. and Nguyen, H. and Nathan, R. and Misra, B. and Hemaidan, A.

DOI: 10.1007/s40121-024-01007-z

Quantitative analysis of the impact of infectious disease physicians on patients in the emergency department fast-track parenteral antibiotics program

BMC Infectious Diseases

McSweeney, C. and Steiner, T. and Grant, J.M.

DOI: 10.1186/s12879-024-09305-0

Correction to: Integrated Safety and Efficacy Analyses of Phase3 Trials of a Microbiome Therapeutic for Recurrent CDI (Infectious Diseases and Therapy, (2024), 13, 10, (2105-2121), 10.1007/s40121-024-01007-z),Correction to: Integrated Safety and Efficacy Analyses of Phase3 Trials of a Microbiome Therapeutic for Recurrent CDI (Infectious Diseases and Therapy, (2024), 13, 10, (2105-2121), 10.1007/

Infectious Diseases and Therapy

Kraft, C.S. and Sims, M. and Silverman, M. and Louie, T.J. and Feuerstadt, P. and Huang, E.S. and Khanna, S. and Berenson, C.S. and Wang, E.E.L. and Cohen, S.H. and Korman, L. and Lee, C. and Kelly, C.R. and Odio, A. and Cook, P.P. and Lashner, B. and Ramesh, M. and Kumar, P. and De, A. and Memisoglu, A. and Lombardi, D.A. and Hasson, B.R. and McGovern, B.H. and von Moltke, L. and Pardi, D.S. and Rozen, S.E. and Tiongco, F.P. and Patel, D. and Salvato, P. and Zahedi, M. and Bochan, M.R. and Joseph, J.M. and Rehman, S.M. and Sarol, J. and Parikh, N. and Hong, J. and Clark, L.E. and El-Nachef, N. and Yen, E.F. and Maher, J.A. and Preiksaitis, H.G. and Adeyafa, B. and Gorrela, S.V. and Nauako, K.W. and Doshi, A.A. and Fernandez, R. and Daccak, R. and Dickstein, G. and Tyagi, V. and Kuliev, A. and Cubillas, M. and Gonzales, C.M. and Arif, A.A. and Trevino, M.E. and Gonzalez-Rojas, Y. and Sarles, H. and Godofsky, E. and Bekal, P.K. and Zafar, Z.N. and Musgrave, B. and Carbonneau, D. and De Beixedon, J. and Skuraba, A. and Valle, E. and Dulitz, D. and Choi, M. and Ellerin, T.B. and Singaram, C. and Boren, K. and Rai, S. and Wilson, J. and Gentry, A. and Coates, A.G. and Brennan, R. and Powell, D. and Rao, S. and Terrelonge, A. and Gupta, A. and Alfonso, T. and Tabbaa, M. and Patel, S. and Lohani, G. and Husain, S.N. and Hanabergh, R. and Branin, B. and Dar, S. and Gebhard, R. and Jamal, M.M. and Parker, M. and Hendrix, E. and Curran, J. and Beshay, M. and Thanawala, R. and Jaeger, R. and Galambos, M. and Jazrawi, S. and Orr, R. and Bangash, I. and Kogan, M. and Hadi, G. and Vincent, J. and Mason, R. and Kumar, S. and Katikaneni, S. and Llana, A.D. and Henry, P. and Higgins, P. and Black, R. and Parekh, R. and Okolo, C. and Sherman, A. and Welker, J. and Welton, T. and Garber, J. and Behm, B. and Flores, L. and Haaksma, J. and Mehmood, T. and Hecht, G. and Hall, M. and Bacon, A. and Stern, J. and Osiyemi, O. and Moya, J. and Gill, S. and Friedenberg, K. and Stanciu, S. and Gumber, S. and Caradonna, R. and Naqvi, S. and Coppola, A. and Tan, M. and Ephtimios, I. and Kayali, Z. and Oubre, B. and Houghton, J. and Barish, C. and Golan, Y. and Gancayco, J. and Wofford, S. and Portnoy, E. and Kim, S. and Johnson, K. and Onwueme, K. and Bullock, J. and Stock, K. and Phillips, R. and Degala, G. and Schmalz, M. and Rutland, T. and Hussain, A. and Surace, L. and Ruthardt, F. and Brook, L. and Sepe, P. and Ramesh, G. and Pinero, J. and Oguchi, G. and Ayub, K. and Benjamin, S. and Talreja, N. and Jamal, A. and DuPont, H. and Abbas, J. and Diaz, J. and Newton, E. and Nadar, V. and Bressler, A. and Pedersen, P. and Gutierrez, J.C.M. and Fogel, R. and Bennett, M. and Berman, L. and Kreines, M. and Weinstock, L. and Guimont, C. and Gauthier, S. and Daley, P. and Butt, D. and Steiner, T. and Grimard, D. and Bogdanovich, T. and Heuer, M. and Shapiro, M. and Arsenescu, R. and Walton, M. and Adams, A. and Hernandez, L. and Patel, M. and Colman, R. and Baird, I.M. and Ritter, T. and Esfandyari, T. and O?Marro, S. and Andrade, G. and Arimie, C. and Garcia-Diaz, J. and Sheikh, A. and Georgetson, M. and Hansen, V. and Smith, K. and Tran, H. and Acosta, I. and Williams, J. and Pullman, J. and Nguyen, H. and Nathan, R. and Misra, B. and Hemaidan, A.

DOI: 10.1007/s40121-024-01036-8

Adaptive immune responses to two-dose COVID-19 vaccine series in healthy Canadian adults > 50 years: a prospective, observational cohort study

Research Square

Gaultier, G.N. and McMillan, B. and Poloni, C. and Lo, M. and Cai, B. and Zheng, J.J. and Baer, H.M. and Shulha, H. and Simmons, K. and Mrquez, A.C. and Bartlett, S.R. and Cook, L. and Levings, M.K. and Steiner, T. and Sekirov, I. and Zlosnik, J.E.A. and Morshed, M. and Skowronski, D.M. and Krajden, M. and Jassem, A.N. and Sadarangani, M.

DOI: 10.21203/rs.3.rs-3214357

Evading the Toll booth: How silent flagellins may bind yet fail to activate TLR5

Science Immunology

Baer, H.M. and Sandilya, S. and Steiner, T.S.

DOI: 10.1126/sciimmunol.adf0244

Clostridioides difficile PCR Tcdb Cycle Threshold predicts toxin EIA positivity but not severity of infection

Anaerobe

Mah, R. and Locher, K. and Steiner, T.S. and Stefanovic, A.

DOI: 10.1016/j.anaerobe.2023.102755

Flagellin-specific human CAR Tregs for immune regulation in IBD

Journal of Autoimmunity

Boardman, D.A. and Wong, M.Q. and Rees, W.D. and Wu, D. and Himmel, M.E. and Orban, P.C. and Vent-Schmidt, J. and Zachos, N.C. and Steiner, T.S. and Levings, M.K.

DOI: 10.1016/j.jaut.2022.102961

Improving care for patients with Clostridioides difficile infection: A clinical practice and healthcare systems perspective

Frontiers in Medicine

Hocking, L. and Wilcox, M. and Petrosillo, N. and Griffin, P. and Steiner, T. and Attara, G. and Dor, J. and Cabling, M. and Stockwell, S. and Romanelli, R.J. and Marjanovic, S.

DOI: 10.3389/fmed.2022.1033417

How to present work productivity loss results from clinical trials for patients and caregivers? A mixed methods approach

Social Science and Medicine

L'Heureux, J. and McTaggart-Cowan, H. and Johns, G. and Chen, L. and Steiner, T. and Tocher, P. and Sun, H. and Zhang, W.

DOI: 10.1016/j.socscimed.2023.115999

T-cell activation"induced marker assays in health and disease

Immunology and Cell Biology

Poloni, C. and Schonhofer, C. and Ivison, S. and Levings, M.K. and Steiner, T.S. and Cook, L.

DOI: 10.1111/imcb.12636

An invitro chronic damage model impairs inflammatory and regenerative responses in human colonoid monolayers

Cell Reports

William D. Rees and Nikita Telkar and David T.S. Lin and May Q. Wong and Chad Poloni and Ayda Fathi and Michael Kobor and Nicholas C. Zachos and Theodore S. Steiner

DOI: 10.1016/j.celrep.2021.110283

01 / 2022

Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses

Immunity

Angkeow, J.W. and Monaco, D.R. and Chen, A. and Venkataraman, T. and Jayaraman, S. and Valencia, C. and Sie, B.M. and Liechti, T. and Farhadi, P.N. and Funez-dePagnier, G. and Sherman-Baust, C.A. and Wong, M.Q. and Ruczinski, I. and Caturegli, P. and Sears, C.L. and Simner, P.J. and Round, J.L. and Duggal, P. and Laserson, U. and Steiner, T.S. and Sen, R. and Lloyd, T.E. and Roederer, M. and Mammen, A.L. and Longman, R.S. and Rider, L.G. and Larman, H.B.

DOI: 10.1016/j.immuni.2022.05.002

A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

Nature

Shapira, T. and Monreal, I.A. and Dion, S.P. and Buchholz, D.W. and Imbiakha, B. and Olmstead, A.D. and Jager, M. and D{\'e}silets, A. and Gao, G. and Martins, M. and Vandal, T. and Thompson, C.A.H. and Chin, A. and Rees, W.D. and Steiner, T. and Nabi, I.R. and Marsault, E. and Sahler, J. and Diel, D.G. and Van de Walle, G.R. and August, A. and Whittaker, G.R. and Boudreault, P.-L. and Leduc, R. and Aguilar, H.C. and Jean, F.

DOI: 10.1038/s41586-022-04661-w

Inhibition of glycogen synthase kinase-3-beta (GSK3) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication

Research Square

Shapira, T. and Rens, C. and Pichler, V. and Rees, W. and Steiner, T. and Jean, F. and Winkler, D. and Sarai, I. and Pelech, S. and Av-Gay, Y.

DOI: 10.21203/rs.3.rs-1197371/v1

Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection Enhances Adaptive Immunity to C difficile Toxin B

Gastroenterology

Laura Cook and William D. Rees and May Q. Wong and Hannah Peters and Megan K. Levings and Theodore S. Steiner

DOI: 10.1053/j.gastro.2021.01.009

05 / 2021

Recurrent Clostridioides difficile Infection Is Associated With Impaired T Helper Type 17 Immunity to C difficile Toxin B

Gastroenterology

Laura Cook and William D. Rees and May Q. Wong and William W. Kwok and Megan K. Levings and Theodore S. Steiner

DOI: 10.1053/j.gastro.2020.11.043

03 / 2021

A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice

bioRxiv

Shapira, T. and Monreal, I.A. and Dion, S.P. and Jager, M. and D{\'e}silets, A. and Olmstead, A.D. and Vandal, T. and Buchholz, D.W. and Imbiakha, B. and Gao, G. and Chin, A. and Rees, W.D. and Steiner, T. and Nabi, I.R. and Marsault, E. and Sahler, J. and August, A. and van de Walle, G. and Whittaker, G.R. and Boudreault, P.-L. and Aguilar, H.C. and Leduc, R. and Jean, F.

DOI: 10.1101/2021.05.03.442520

Safety, immunogenicity, and efficacy of a Clostridioides difficile toxoid vaccine candidate: a phase 3 multicentre, observer-blind, randomised, controlled trial

The Lancet Infectious Diseases

de Bruyn, G. and Gordon, D.L. and Steiner, T. and Tambyah, P. and Cosgrove, C. and Martens, M. and Bassily, E. and Chan, E.-S. and Patel, D. and Chen, J. and Torre-Cisneros, J. and Fernando De Magalh{\~a}es Francesconi, C. and Gesser, R. and Jeanfreau, R. and Launay, O. and Laot, T. and Morfin-Otero, R. and Oviedo-Orta, E. and Park, Y.S. and Piazza, F.M. and Rehm, C. and Rivas, E. and Self, S. and Gurunathan, S.

DOI: 10.1016/S1473-3099(20)30331-5

Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo-controlled, phase 3 trial

The Lancet Respiratory Medicine

Lescure, F.-X. and Honda, H. and Fowler, R.A. and Lazar, J.S. and Shi, G. and Wung, P. and Patel, N. and Hagino, O. and Bazzalo, I.J. and Casas, M.M. and Nu{\~n}ez, S.A. and Pere, Y. and Ibarrola, C.M. and Solis Aramayo, M.A. and Cuesta, M.C. and Duarte, A.E. and Gutierrez Fernandez, P.M. and Iannantuono, M.A. and Miyazaki, E.A. and Silvio, J.P. and Scublinsky, D.G. and Bales, A. and Catarino, D. and Fiss, E. and Mohrbacher, S. and Sato, V. and Baylao, A. and Cavalcante, A. and Correa, F. and de Andrade, C.A. and Furtado, J. and Ribeiro Filho, N. and Telles, V. and Trevelin, L.T. and Vipich, R. and Boldo, R. and Borges, P. and Lobo, S. and Luckemeyer, G. and Machado, L. and Alves, M.B. and Iglessias, A.C. and Lago, M.M. and Santos, D.W. and Chapdelaine, H. and Falcone, E.L. and Jamal, R. and Luong, M.-L. and Durand, M. and Doucet, S. and Carrier, F.-M. and Coburn, B.A. and Del Sorbo, L. and Walmsley, S.L. and Belga, S. and Chen, L.Y. and Mah, A.D. and Steiner, T. and Wright, A.J. and Hajek, J. and Adhikari, N. and Fowler, R.A. and Daneman, N. and Khwaja, K.A. and Shahin, J. and Gonzalez, C. and Silva, R. and Lindh, M. and Maluenda, G. and Fernandez, P. and Oyonarte, M. and Lasso, M. and Boyer, A. and Bronnimann, D. and Bui, H.-N. and Cazanave, C. and Chaussade, H. and Desclaux, A. and Ducours, M. and Duvignaud, A. and Malvy, D. and Martin, L. and Neau, D. and Nguyen, D. and Pistone, T. and Soubrane-Wirth, G. and Leitao, J. and Allavena, C. and Biron, C. and Bouchez, S. and Gaborit, B. and Gregoire, A. and Le Turnier, P. and Lecompte, A.-S. and Lecomte, R. and Lefebvre, M. and Raffi, F. and Boutoille, D. and Morineau, P.H. and Gu{\'e}ry, R. and Chatelus, E. and Dumoussaud, N. and Felten, R. and Luca, F. and Goichot, B. and Schneider, F. and Taquet, M.-C. and Groh, M. and Roumier, M. and Neuville, M. and Bachelard, A. and Isernia, V. and Lescure, F.-X. and Phung, B.-C. and Rachline, A. and Sautereau, A. and Vallois, D. and Bleher, Y. and Boucher, D. and Coudon, C. and Esnault, J. and Guimard, T. and Leautez-Nainville, S. and Merrien, D. and Morrier, M. and Motte-Vincent, P. and Gabeff, R. and Leclerc, H. and Cozic, C. and Decours, R. and F{\'e}vrier, R. and Colin, G. and Abgrall, S. and Vignes, D. and Sterpu, R. and Kuellmar, M. and Meersch-Dini, M. and Weiss, R. and Zarbock, A. and Antony, C. and Berger, M. and Brenner, T. and Taube, C. and Herbstreit, F. and Dolff, S. and Konik, M. and Schmidt, K. and Zettler, M. and Witzke, O. and Boell, B. and Garcia Borrega, J. and Koehler, P. and Zander, T. and Dusse, F. and Al-Sawaf, O. and K{\"o}hler, P. and Eichenauer, D. and Kochanek, M. and Shimabukuro-Vornhagen, A. and Mellinghoff, S. and Cla{\ss}en, A. and Heger, J.-M. and Meyer-Schwickerath, C. and Liedgens, P. and Heindel, K. and Belkin, A. and Biber, A. and Gilboa, M. and Levy, I. and Litachevsky, V. and Rahav, G. and Finesod Wiedner, A. and Zilberman-Daniels, T. and Oster, Y. and Strahilevitz, J. and Sviri, S. and Baldissera, E.M. and Campochiaro, C. and Cavalli, G. and Dagna, L. and De Luca, G. and Della Torre, E. and Tomelleri, A. and Bernasconi De Luca, D. and Capetti, A.F. and Coen, M. and Cossu, M.V. and Galli, M. and Giacomelli, A. and Gubertini, G.A. and Rusconi, S. and Burastero, G.J. and Digaetano, M. and Guaraldi, G. and Meschiari, M. and Mussini, C. and Puzzolante, C. and Volpi, S. and Aiello, M. and Ariani, A. and Chetta, A.A. and Frizzelli, A. and Ticinesi, A. and Tuttolomondo, D. and Aliberti, S. and Blasi, F.B. and Di Pasquale, M.F. and Misuraca, S. and Pilocane, T. and Simonetta, E. and Aghelmo, A.M. and Angelini, C. and Brunetta, E. and Canonica, G.W. and Ciccarelli, M. and Dal Farra, S. and De Santis, M. and Ferri, S. and Folci, M. and Guidelli, G.M. and Heffler, E.M. and Loiacono, F. and Malipiero, G. and Paoletti, G. and Pedale, R. and Puggioni, F.A. and Racca, F. and Zumbo, A. and Satou, M. and Lisun, T. and Protsenko, D. and Rubtsov, N. and Beloglazova, I. and Fomina, D. and Lysenko, M. and Serdotetskova, S. and Firstov, V. and Gordeev, I. and Kokorin, I. and Komissarova, K. and Lapochkina, N. and Luchinkina, E. and Malimon, V. and Mamedguseyinova, S. and Polubatonova, K. and Suvorova, N. and Arribas, J. and Borobia Perez, A.M. and de la Calle Prieto, F. and Figueira, J.C. and Motejano Sanchez, R. and Mora-Rillo, M. and Prados Sanchez, C. and Queiruga Parada, J. and Fernandez Arnalich, F. and Guerro Barrientos, M. and Bendala Estrada, A. and Caballero Marcos, A. and Garcia Leoni, M.E. and Garc{\'i}a-Mart{\'i}nez, R. and Collado, A.M. and Munoz Garcia, P. and Torres do Rego, A. and Villalba Garc{\'i}a, M.V. and Burrillo, A. and Valerio Minero, M. and Gijon Vidaurreta, P. and Infante Herrero, S. and Velilla, E. and Machado, M. and Olmedo, M. and Pinilla, B. and Almirante Gragera, B. and Ca{\~n}as Ruano, M.D.L.E. and Contreras Medina, S. and Cort{\'e}s Herrera, A. and Falc{\'o} Ferrer, V. and Ferrer Roca, R. and Nuvials Casals, X. and Ribera Pascuet, E. and Suanzes Diez, P. and Rebollo Castro, P. and Garcia Alcaide, F. and Soriano, A. and Oliver Caldes, A. and Gonz{\'a}lez Cord{\'o}n, A. and Cardozo, C. and De la Mora Ca{\~n}izo, L. and Pena L{\'o}pez, R. and Chamorro, S. and Crespillo-Andujar, C. and Escudero Sanchez, R. and Fort{\'u}n-Abete, J. and Monge-Maillo, B. and Moreno Zamora, A. and Norman, F. and Sanchez Conde, M. and Serrano Villar, S. and Vizcarra, P.

DOI: 10.1016/S2213-2600(21)00099-0

Prevalence, persistence, and genetics of antibody responses to protein toxins and virulence factors

bioRxiv

Angkeow, J.W. and Monaco, D.R. and Chen, A. and Venkataraman, T. and Jayaraman, S. and Valencia, C. and Sie, B.M. and Liechti, T. and Farhadi, P.N. and Funez-DePagnier, G. and Sherman-Baust, C.A. and Wong, M.Q. and Sears, C.L. and Simner, P.J. and Round, J.L. and Duggal, P. and Laserson, U. and Steiner, T.S. and Sen, R. and Lloyd, T.E. and Roederer, M. and Mammen, A.L. and Longman, R.S. and Rider, L.G. and Larman, H.B.

DOI: 10.1101/2021.10.01.462481

Regenerative Intestinal Stem Cells Induced by Acute and Chronic Injury: The Saving Grace of the Epithelium?

Frontiers in cell and developmental biology

Rees WD and Tandun R and Yau E and Zachos NC and Steiner TS

DOI: 10.3389/fcell.2020.583919 PubMed: 33282867

11 / 2020

A method for expansion and retroviral transduction of mouse regulatory T cells.

Journal of immunological methods

Wu D and Wong MQ and Vent-Schmidt J and Boardman DA and Steiner TS and Levings MK

DOI: 10.1016/j.jim.2020.112931 PubMed: 33221458

11 / 2020

Mycobacterium avium Subspecies paratuberculosis Infects and Replicates within Human Monocyte-Derived Dendritic Cells.

Microorganisms

Rees WD and Lorenzo-Leal AC and Steiner TS and Bach H

DOI: 10.3390/microorganisms8070994 PubMed: 32635236

07 / 2020

Analysis of Flagellin-Specific Adaptive Immunity Reveals Links to Dysbiosis in Patients With Inflammatory Bowel Disease

Cellular and Molecular Gastroenterology and Hepatology

Cook, L. and Lisko, D.J. and Wong, M.Q. and Garcia, R.V. and Himmel, M.E. and Seidman, E.G. and Bressler, B. and Levings, M.K. and Steiner, T.S.

DOI: 10.1016/j.jcmgh.2019.11.012

How do immune and mesenchymal cells influence the intestinal epithelial cell compartment in inflammatory bowel disease? Let's crosstalk about it!

Journal of Leukocyte Biology

Rees, W.D. and Sly, L.M. and Steiner, T.S.

DOI: 10.1002/JLB.3MIR0120-567R

Enteroids derived from inflammatory bowel disease patients display dysregulated endoplasmic reticulum stress pathways, leading to differential inflammatory responses and dendritic cell maturation

Journal of Crohn's and Colitis

Rees, W.D. and Stahl, M. and Jacobson, K. and Bressler, B. and Sly, L.M. and Vallance, B.A. and Steiner, T.S.

DOI: 10.1093/ECCO-JCC/JJZ194

Patients' Willingness and Perspectives Toward Chimeric Antigen Receptor T-Regulatory Cell Therapy for Inflammatory Bowel Diseases

Crohn's and Colitis 360

Vent-Schmidt, J. and Goldsmith, L.J. and Steiner, T.S.

DOI: 10.1093/crocol/otaa085

Patient experiences with clostridioides difficile infection: Results of a Canada-wide survey

Patient Preference and Adherence

Vent-Schmidt, J. and Attara, G.P. and Lisko, D. and Steiner, T.S.

DOI: 10.2147/PPA.S229539

Impaired Th17 immunity in recurrent C. difficile infection is ameliorated by fecal microbial transplantation

medRxiv

Cook, L. and Rees, W.D. and Wong, M.Q. and Wang, X. and Peters, H. and Oliveira, L. and Lau, T. and Mah, R. and Bressler, B. and Gomez, R. and Chow, I.-T. and James, E.A. and Kwok, W.W. and Levings, M.K. and Steiner, T.S.

DOI: 10.1101/2020.06.05.20114876

Phosphatidylinositol 3-kinase p110d drives intestinal fibrosis in SHIP deficiency

Mucosal Immunology

Lo, Y. and Sauve, J.P. and Menzies, S.C. and Steiner, T.S. and Sly, L.M.

DOI: 10.1038/s41385-019-0191-z

Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells

Gastroenterology

Cook, L. and Stahl, M. and Han, X. and Nazli, A. and MacDonald, K.N. and Wong, M.Q. and Tsai, K. and Dizzell, S. and Jacobson, K. and Bressler, B. and Kaushic, C. and Vallance, B.A. and Steiner, T.S. and Levings, M.K.

DOI: 10.1053/j.gastro.2019.09.002

Whole blood human transcriptome and virome analysis of ME/CFS patients experiencing post-exertional malaise following cardiopulmonary exercise testing

PLoS ONE

Bouquet, J. and Li, T. and Gardy, J.L. and Kang, X. and Stevens, S. and Stevens, J. and VanNess, M. and Snell, C. and Potts, J. and Miller, R.R. and Morshed, M. and McCabe, M. and Parker, S. and Uyaguari, M. and Tang, P. and Steiner, T. and Chan, W.-S. and De Souza, A.-M. and Mattman, A. and Patrick, D.M. and Chiu, C.Y.

DOI: 10.1371/journal.pone.0212193

Adaptive immune response to Clostridium difficile infection: A perspective for prevention and therapy

European Journal of Immunology

Rees, W.D. and Steiner, T.S.

DOI: 10.1002/eji.201747295

Association of medical microbiology and infectious disease canada treatment practice guidelines for clostridium difficile infection

JAMMI

Loo, V.G. and Davis, I. and Embil, J. and Evans, G.A. and Hota, S. and Lee, C. and Lee, T.C. and Longtin, Y. and Louie, T. and Moayyedi, P. and Poutanen, S. and Simor, A.E. and Steiner, T. and Thampi, N. and Valiquette, L.

DOI: 10.3138/jammi.2018.02.13

Associations of DC-SIGN (CD209) promoter -336G/A polymorphism (rs4804803) with dengue infection: A systematic review and meta-analysis

Acta Tropica

Pabalan, N. and Chaisri, S. and Tabunhan, S. and Phumyen, A. and Jarjanazi, H. and Steiner, T.S.

DOI: 10.1016/j.actatropica.2017.10.017

Case report: Ivermectin and Albendazole Plasma concentrations in a patient with disseminated strongyloidiasis on extracorporeal membrane oxygenation and continuous renal replacement therapy

American Journal of Tropical Medicine and Hygiene

Boodman, C. and Chhonker, Y.S. and Murry, D.J. and Mah, A. and Grant, J. and Steiner, T. and Libman, M. and Nishi, C. and Charles, M.

DOI: 10.4269/ajtmh.18-0487

Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection.

The New England journal of medicine

DOI: 10.1056/nejmoa1602615 PubMed: 28121498

01 / 2017

Associations of tumor necrosis factor-a-308 polymorphism with dengue infection: A systematic review and meta-analysis

Acta Tropica

Pabalan, N. and Chaisri, S. and Tabunhan, S. and Tarasuk, M. and Jarjanazi, H. and Steiner, T.

DOI: 10.1016/j.actatropica.2017.05.007

RNA-seq analysis of gene expression, viral pathogen, and b-cell/t-cell receptor signatures in complex chronic disease

Clinical Infectious Diseases

Bouquet, J. and Gardy, J.L. and Brown, S. and Pfeil, J. and Miller, R.R. and Morshed, M. and Avina-Zubieta, A. and Shojania, K. and McCabe, M. and Parker, S. and Uyaguari, M. and Federman, S. and Tang, P. and Steiner, T. and Otterstater, M. and Holt, R. and Moore, R. and Chiu, C.Y. and Patrick, D.M.

DOI: 10.1093/cid/ciw767

2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea

Clinical Infectious Diseases

Shane, A.L. and Mody, R.K. and Crump, J.A. and Tarr, P.I. and Steiner, T.S. and Kotloff, K. and Langley, J.M. and Wanke, C. and Warren, C.A. and Cheng, A.C. and Cantey, J. and Pickering, L.K.

DOI: 10.1093/cid/cix669

CD4+ T Cells Specific for C.difficile Toxins are a Marker of Patients with Active Relapsing Disease.

Open forum infectious diseases

Infections due to Escherichia coli and Other Enteric Gram-Negative Bacilli

Scientific American Medicine

Allison Mah, Inna Sekirov, Theodore Steiner. (2016). Infections due to Escherichia coli and Other Enteric Gram-Negative Bacilli. A. Singh. Scientific American Medicine. Published, Scientific American Press, United States

Metagenomic investigation of plasma in individuals with ME/CFS Highlights the importance of technical controls to elucidate contamination and batch effects

PLoS ONE

Miller, R.R. and Uyaguari-Diaz, M. and McCabe, M.N. and Montoya, V. and Gardy, J.L. and Parker, S. and Steiner, T. and Hsiao, W. and Nesbitt, M.J. and Tang, P. and Patrick, D.M.

DOI: 10.1371/journal.pone.0165691

Fecal microbiota transplantation for the intestinal decolonization of extensively antimicrobial-resistant opportunistic pathogens: A review

Infectious Diseases

Manges, A.R. and Steiner, T.S. and Wright, A.J.

DOI: 10.1080/23744235.2016.1177199

Antimicrobial Resistance in Enteric Gram-Negative Organisms

Scientific American Medicine

Allison Mah, Inna Sekirov, Theodore Steiner. (2016). Antimicrobial Resistance in Enteric Gram-Negative Organisms. A. Singh. Scientific American Medicine. Published, Scientific American Press, United States

Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent clostridium difficile infection a randomized clinical trial

JAMA - Journal of the American Medical Association

Lee, C.H. and Steiner, T. and Petrof, E.O. and Smieja, M. and Roscoe, D. and Nematallah, A. and Scott Weese, J. and Collins, S. and Moayyedi, P. and Crowther, M. and Ropeleski, M.J. and Jayaratne, P. and Higgins, D. and Li, Y. and Rau, N.V. and Kim, P.T.

DOI: 10.1001/jama.2015.18098

Diagnosis and management of foodborne infectious diseases

Food Microbiology: In Human Health and Disease

Steiner, T.

New Insights into Shiga Toxigenic Escherichia coli Pathogenesis: When Less is More

Journal of Infectious Diseases

Steiner, T.S.

DOI: 10.1093/infdis/jiv558

Longitudinal clinical findings and outcome among patients with cryptococcus gattii infection in British Columbia

Clinical Infectious Diseases

Phillips, P. and Galanis, E. and Macdougall, L. and Chong, M.Y. and Balshaw, R. and Cook, V.J. and Bowie, W. and Steiner, T. and Hoang, L. and Morshed, M. and Ghesquiere, W. and Forrest, D.M. and Roscoe, D. and Doyle, P. and Kibsey, P.C. and Connolly, T. and Mirzanejad, Y. and Thompson, D. and Saliken, J. and Sanders, B. and Partlow, E. and Vortel, J. and Arikan, Y. and Fyfe, M.

DOI: 10.1093/cid/civ041

Tr1 cells, but not foxp3+ regulatory T cells, suppress NLRP3 inflammasome activation via an IL-10-dependent mechanism

Journal of Immunology

Yao, Y. and Vent-Schmidt, J. and McGeough, M.D. and Wong, M. and Hoffman, H.M. and Steiner, T.S. and Levings, M.K.

DOI: 10.4049/jimmunol.1403225

Mediators of Inflammation: Inflammation in Cancer, Chronic Diseases, and Wound Healing

Mediators of Inflammation

Du, C. and Bhatia, M. and Tang, S.C.W. and Zhang, M. and Steiner, T.

DOI: 10.1155/2015/570653

Submaximal exercise testing with near-infrared spectroscopy in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients compared to healthy controls: A case-control study

Journal of Translational Medicine

Miller, R.R. and Reid and Mattman, A. and Yamabayashi, C. and Steiner, T. and Parker, S. and Gardy, J. and Tang, P. and Patrick, D.M.

DOI: 10.1186/s12967-015-0527-8

Evaluation of a Clostridium difficile infection management policy with clinical pharmacy and medical microbiology involvement at a major Canadian teaching hospital

Journal of Clinical Pharmacy and Therapeutics

Yeung, S.S.T. and Yeung, J.K. and Lau, T.T.Y. and Forrester, L.A. and Steiner, T.S. and Bowie, W.R. and Bryce, E.A.

DOI: 10.1111/jcpt.12329

Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome

Fatigue: Biomedicine, Health and Behavior

Patrick, D.M. and Miller, R.R. and Steiner, T. and Gardy, J.L. and Parker, S.M. and Tang, P.

DOI: 10.1080/21641846.2015.1024004

A surprising cause of chronic cough

New England Journal of Medicine

Damaraju, D. and Steiner, T. and Wade, J. and Gin, K. and Fitz Gerald, J.M.

DOI: 10.1056/NEJMcps1303787

Lyme Disease Diagnosed by Alternative Methods: A Phenotype Similar to That of Chronic Fatigue Syndrome

Clinical Infectious Diseases

Patrick, D.M. and Miller, R.R. and Gardy, J.L. and Parker, S.M. and Morshed, M.G. and Steiner, T.S. and Singer, J. and Shojania, K. and Tang, P. and Mattman, A. and Sirrs, S. and Reid, W.D. and Phillips, P. and Avina-Zubieta, A. and Reynolds, J. and Wong, H. and Bested, A. and Hyams, I. and Ng, B. and Blaney, G. and Spinelli, J. and Isaac-Renton, J. and Hoang, L. and Krajden, M. and McCabe, M.

DOI: 10.1093/cid/civ470

The worst of both worlds: Examining the hypervirulence of the shigatoxigenic/enteroaggregative Escherichia coli O104:H4

Journal of Infectious Diseases

Steiner, T.S.

DOI: 10.1093/infdis/jiu400

Meta-analysis in microbiology

Indian Journal of Medical Microbiology

Pabalan, N. and Jarjanazi, H. and Steiner, T.

DOI: 10.4103/0255-0857.136547

A Non-Synonymous Coding Variant (L616F) in the TLR5 Gene Is Potentially Associated with Crohn's Disease and Influences Responses to Bacterial Flagellin

PLoS ONE

Sheridan, J. and Mack, D.R. and Amre, D.K. and Israel, D.M. and Cherkasov, A. and Li, H. and Grimard, G. and Steiner, T.S.

DOI: 10.1371/journal.pone.0061326

Enteroaggregative Escherichia coli and acute diarrhea in children: A meta-analysis of South Asian populations

European Journal of Clinical Microbiology and Infectious Diseases

Pabalan, N. and Singian, E. and Jarjanazi, H. and Steiner, T.S.

DOI: 10.1007/s10096-012-1779-3

Pulmonary mucormycosis in a patient with Crohn disease on immunosuppressive medications including infliximab.

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

DOI: 10.1155/2013/363250 PubMed: 24421803

Treating foodborne illness

Infectious Disease Clinics of North America

Steiner, T.

DOI: 10.1016/j.idc.2013.05.006

Helios+ and Helios- cells coexist within the natural Foxp3+ T regulatory cell subset in humans

Journal of Immunology

Himmel, M.E. and MacDonald, K.G. and Garcia, R.V. and Steiner, T.S. and Levings, M.K.

DOI: 10.4049/jimmunol.1201379

Escherichia Coli Enteric Infections

Goldman's Cecil Medicine: Twenty Fourth Edition

Steiner, T.S. and Guerrant, R.L.

DOI: 10.1016/B978-1-4377-1604-7.00312-2

ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation

European Journal of Immunology

Yao, Y. and Levings, M.K. and Steiner, T.S.

DOI: 10.1002/eji.201142213

Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor--deficient mice

Inflammatory Bowel Diseases

Hardenberg, G. and Yao, Y. and Piccirillo, C.A. and Levings, M.K. and Steiner, T.S.

DOI: 10.1002/ibd.21738

Regulatory T-cell therapy for inflammatory bowel disease: More questions than answers

Immunology

Himmel, M.E. and Yao, Y. and Orban, P.C. and Steiner, T.S. and Levings, M.K.

DOI: 10.1111/j.1365-2567.2012.03572.x

Endoplasmic reticulum stress modulates TLR responses in intestinal epithelial cells

Inflammatory Bowel Diseases

Theodore Steiner and Jiyoung Hwang and David Shin and Yu Yao

DOI: 10.1097/00054725-201112002-00269

Environmental influences on T regulatory cells in inflammatory bowel disease

Seminars in Immunology

Hardenberg, G. and Steiner, T.S. and Levings, M.K.

DOI: 10.1016/j.smim.2011.01.012

Human CD4+FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils

European Journal of Immunology

Himmel, M.E. and Crome, S.Q. and Ivison, S. and Piccirillo, C. and Steiner, T.S. and Levings, M.K.

DOI: 10.1002/eji.201040459

The Stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells

Inflammatory Bowel Diseases

Ivison, S.M. and Himmel, M.E. and Mayer, M. and Yao, Y. and Kifayet, A. and Levings, M.K. and Steiner, T.S.

DOI: 10.1002/ibd.21428

Autoactivation of the AggR regulator of enteroaggregative Escherichia coli in vitro andin vivo

FEMS Immunology & Medical Microbiology

Nicholas Morin and Chelsea Tirling and Sabine M. Ivison and Ajinder Pal Kaur and James P. Nataro and Theodore S. Steiner

DOI: 10.1111/j.1574-695x.2010.00645.x

01 / 2010

Autoactivation of the AggR regulator of enteroaggregative Escherichia coli in vitro and in vivo

FEMS Immunology and Medical Microbiology

Morin, N. and Tirling, C. and Ivison, S.M. and Kaur, A.P. and Nataro, J.P. and Steiner, T.S.

DOI: 10.1111/j.1574-695X.2009.00645.x

Protein kinase D1 and D2 are involved in chemokine release induced by toll-like receptors 2, 4, and 5

Cellular Immunology

Steiner, T.S. and Ivison, S.M. and Yao, Y. and Kifayet, A.

DOI: 10.1016/j.cellimm.2010.05.012

Principles and Syndromes of Enteric Infection

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases

THEODORE S. STEINER and RICHARD L. GUERRANT

DOI: 10.1016/b978-0-443-06839-3.00093-x

TLR5 is not required for flagellin-mediated exacerbation of DSS colitis

Inflammatory Bowel Diseases

Ivison, S.M. and Himmel, M.E. and Hardenberg, G. and Wark, P.A.J. and Kifayet, A. and Levings, M.K. and Steiner, T.S.

DOI: 10.1002/ibd.21097

Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin

American Journal of Physiology - Gastrointestinal and Liver Physiology

Ivison, S.M. and Wang, C. and Himmel, M.E. and Sheridan, J. and Delano, J. and Mayer, M.L. and Yao, Y. and Kifayet, A. and Steiner, T.S.

DOI: 10.1152/ajpgi.00089.2010

The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells

Journal of Immunology

Khan, M.A. and Steiner, T.S. and Sham, H.P. and Bergstrom, K.S. and Huang, J.T. and Assi, K. and Salh, B. and Tai, I.T. and Li, X. and Vallance, B.A.

DOI: 10.4049/jimmunol.0900021

The p110a and p110 isoforms of class i phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells

Mediators of Inflammation

Ivison, S.M. and Khan, M.A.S. and Graham, N.R. and Shobab, L.A. and Yao, Y. and Kifayet, A. and Sly, L.M. and Steiner, T.S.

DOI: 10.1155/2010/652098

Spread of Cryptococcus gattii into Pacific Northwest region of the United States.

Emerging infectious diseases

DOI: 10.3201/eid1508.081384 PubMed: 19757550

08 / 2009

S1654 Intrarectal ATP Increases the Severity of DSS Colitis and Augments Anti-Flagellin Antibody Production

Gastroenterology

Sabine M. Ivison and Matthew Mayer and Theodore S. Steiner

DOI: 10.1016/s0016-5085(09)61100-8

05 / 2009

T1711 ATP Augments Intestinal Epithelial Inflammatory Responses to Flagellin

Gastroenterology

Sabine M. Ivison and Megan HImmel and Jonathan Delano and Nancy Y. Yao and Theodore S. Steiner

DOI: 10.1016/s0016-5085(09)62592-0

05 / 2009

Dexamethasone in cryptococcus gattii central nervous system infection

Clinical Infectious Diseases

Phillips, P. and Chapman, K. and Sharp, M. and Harrison, P. and Vortel, J. and Steiner, T. and Bowie, W.

DOI: 10.1086/603554

Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium

Infection and Immunity

Khan, M.A. and Bouzari, S. and Ma, C. and Rosenberger, C.M. and Bergstrom, K.S.B. and Gibson, D.L. and Steiner, T.S. and Vallance, B.A.

DOI: 10.1128/IAI.01141-07

Anti-flagellin antibodies in irritable bowel syndrome: Another attack on our commensals?

Neurogastroenterology and Motility

Ivison, S.M. and Steiner, T.S.

DOI: 10.1111/j.1365-2982.2008.01199.x

The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease

Immunology

Himmel, M.E. and Hardenberg, G. and Piccirillo, C.A. and Steiner, T.S. and Levings, M.K.

DOI: 10.1111/j.1365-2567.2008.02939.x

A phosphorylation site in the Toll-like receptor 5 TIR domain is required for inflammatory signalling in response to flagellin

Biochemical and Biophysical Research Communications

Ivison, S.M. and Khan, M.A.S. and Graham, N.R. and Bernales, C.Q. and Kaleem, A. and Tirling, C.O. and Cherkasov, A. and Steiner, T.S.

DOI: 10.1016/j.bbrc.2006.11.132

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

International Immunology

Allan, S.E. and Crome, S.Q. and Crellin, N.K. and Passerini, L. and Steiner, T.S. and Bacchetta, R. and Roncarolo, M.G. and Levings, M.K.

DOI: 10.1093/intimm/dxm014

Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin

Journal of Immunology

Ivison, S.M. and Graham, N.R. and Bernales, C.Q. and Kifayet, A. and Ng, N. and Shobab, L.A. and Steiner, T.S.

DOI: 10.4049/jimmunol.178.9.5735

How flagellin and toll-like receptor 5 contribute to enteric infection

Infection and Immunity

Steiner, T.S.

DOI: 10.1128/IAI.01506-06

Enteric Escherichia coli Infections

Tropical Infectious Diseases

Steiner, T.S. and Thielman, N.M. and Guerrant, R.L.

DOI: 10.1016/B978-0-443-06668-9.50021-1

Infectious diarrhea: New pathogens and new challenges in developed and developing areas

Clinical Infectious Diseases

Steiner, T.S. and Samie, A. and Guerrant, R.L.

DOI: 10.1086/505874

Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 +CD25+ T regulatory cells

Journal of Immunology

Crellin, N.K. and Garcia, R.V. and Hadisfar, O. and Allan, S.E. and Steiner, T.S. and Levings, M.K.

DOI: 10.4049/jimmunol.175.12.8051

Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activation

Immunology

Khan, M.A.S. and Kang, J. and Steiner, T.S.

DOI: 10.1111/j.1365-2567.2004.01923.x

Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis.

The American journal of tropical medicine and hygiene

PubMed: 12685639

03 / 2003

Interleukin-8, tumor necrosis factor-a, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis

American Journal of Tropical Medicine and Hygiene

Alcantara, C.S. and Yang, C.-H. and Steiner, T.S. and Barrett, L.J. and Lima, A.A.M. and Chappell, C.L. and Okhuysen, P.C. and White Jr., A.C. and Guerrant, R.L.

DOI: 10.4269/ajtmh.2003.68.325

Mechanisms of emerging diarrheagenic Escherichia coli infection

Current Infectious Disease Reports

Mohammed A. Khan and Ted S. Steiner

DOI: 10.1007/s11908-002-0050-y

03 / 2002

Enteroaggregative and Diffusely Adherent Escherichia Coli

Escherichia Coli

James P. Nataro and Theodore Steiner

DOI: 10.1016/b978-012220751-8/50007-0

Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5

Journal of Biological Chemistry

Donnelly, M.A. and Steiner, T.S.

DOI: 10.1074/jbc.M206851200

Practice guidelines for the management of infectious diarrhea

Clinical Infectious Diseases

Guerrant, R.L. and Van Gilder, T. and Slutsker, L. and Tauxe, R.V. and Hennessy, T. and Griffin, P.M. and Pickering, L.K. and Steiner, T.S. and Thielman, N.M. and DuPont, H. and Bradley Sack, R. and Tarr, P. and Neill, M. and Nachamkin, I. and Reller, L.B. and Osterholm, M.T. and Bennish, M.L.

DOI: 10.1086/318514

Role of inducible cyclooxygenase and prostaglandins in Clostridium difficile toxin A-induced secretion and inflammation in an animal model

Journal of Infectious Diseases

Alcantara, C. and Stenson, W.F. and Steiner, T.S. and Guerrant, R.L.

DOI: 10.1086/322799

Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells

Journal of Clinical Investigation

Steiner, T.S. and Nataro, J.P. and Poteet-Smith, C.E. and Smith, J.A. and Guerrant, R.L.

DOI: 10.1172/JCI8892

Failure of amphotericin B colloidal dispersion in the treatment of paracoccidioidomycosis.

The American journal of tropical medicine and hygiene

PubMed: 10344661

05 / 1999

Failure of amphotericin B colloidal dispersion in the treatment of paracoccidioidomycosis

American Journal of Tropical Medicine and Hygiene

Dietze, R. and Fowler Jr., V.G. and Steiner, T.S. and Pecanha, P.M. and Corey, G.R.

DOI: 10.4269/ajtmh.1999.60.837

How intestinal bacteria cause disease

Journal of Infectious Diseases

Guerrant, R.L. and Steiner, T.S. and Lima, A.A.M. and Bobak, D.A.

DOI: 10.1086/513845

Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta.

Infection and immunity

PubMed: 9746596

10 / 1998

Enteroaggregative Escherichia coli produce intestinal inflammation and growth impairment and cause interleukin-8 release from intestinal epithelial cells

Journal of Infectious Diseases

Steiner, T.S. and Lima, A.A.M. and Nataro, J.P. and Guerrant, R.L.

DOI: 10.1086/513809

Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: Role of interleukin 1

Infection and Immunity

Rocha, M.F.G. and Soares, A.M. and Flores, C.A. and Steiner, T.S. and Lyerly, D.M. and Guerrant, R.L. and Ribeiro, R.A. and Lima, A.A.M.

DOI: 10.1128/iai.66.10.4910-4916.1998

Enteroaggregative Escherichia coli

Emerging Infectious Diseases

Nataro, J.P. and Steiner, T. and Guerrant, R.L.

DOI: 10.3201/eid0402.980212

Fecal lactoferrin, interleukin-1beta, and interleukin-8 are elevated in patients with severe Clostridium difficile colitis.

Clinical and diagnostic laboratory immunology

PubMed: 9384296

11 / 1997

Protozoal agents: What are the dangers for the public water supply?

Annual Review of Medicine

Steiner, T.S. and Thielman, N.M. and Guerrant, R.L.

DOI: 10.1146/annurev.med.48.1.329

Fecal lactoferrin, interleukin-1, and interleukin-8 are elevated in patients with severe Clostridium difficile colitis

Clinical and Diagnostic Laboratory Immunology

Steiner, T.S. and Flores, C.A. and Pizarro, T.T. and Guerrant, R.L.

DOI: 10.1128/cdli.4.6.719-722.1997

Identification of a protein from enteroaggregative Escherichia coli which releases interteukin 8 from caco-2 intestinal epithelial cells

Clinical Infectious Diseases

Steiner, T.S. and Nataro, J.P. and Guerrant, R.L.

New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae.

Infection and immunity

PubMed: 8675353

06 / 1996

The pathogenesis of and host response to Cryptosporidium parvum

Current Opinion in Infectious Diseases

Steiner, T.S. and Guerrant, R.L.

DOI: 10.1097/00001432-199606000-00005

Diarrhea, demography and cell signaling: lessons from microbial toxins.

Transactions of the American Clinical and Climatological Association

Guerrant, R.L. and Lima, A.A. and Thielman, N.M. and Steiner, T.S. and Fonteles, M.C.

New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and O139 Vibrio cholerae

Infection and Immunity

Silva, T.M.J. and Schleupner, M.A. and Tacket, C.O. and Steiner, T.S. and Kaper, J.B. and Edelman, R. and Guerrant, R.L.

DOI: 10.1128/iai.64.6.2362-2364.1996

Secretin receptors mediating rat forestomach relaxation.

The American journal of physiology

PubMed: 8498512

05 / 1993

Secretin receptors mediating rat forestomach relaxation

American Journal of Physiology - Gastrointestinal and Liver Physiology

Steiner, T.S. and Mangel, A.W. and McVey, D.C. and Vigna, S.R.

DOI: 10.1152/ajpgi.1993.264.5.g863

Current Projects

My current research program targets two very important intestinal diseases: C. difficile infection and inflammatory bowel disease. C. difficile is the leading cause of hospital-acquired infections in Canada, and can lead to debilitating or even fatal diarrhea. I am exploring the role of the immune system in protecting against C. difficile by studying specific types of immune responses in people with their first episode of infection and comparing them to people with recurrent infections. I also have several clinical projects examining the benefit of fecal microbial transplantation (FMT), also known as "stool transplant", to control these recurrent infections.

My second main project is to develop a new treatment for inflammatory bowel disease (IBD; ulcerative colitis and Crohn's disease) based on the realization that people with these diseases develop abnormal immune responses to normal gut bacteria. It is believed that these responses "trick" the gut into thinking there is a bad infection, so it mobilizes its "army" of white blood cells into the gut, leading to unwanted inflammation that damages the gut. We are working to take advantage of these abnormal responses by making "super-suppressor" cells that reduce inflammation when they sense a major bacterial protein, flagellin, which is present in large amounts in the gut. We are also examining the types of immune responses that people with IBD make against flagellin to better understand how they cause damage.

Grants

Canadian Institutes of Health Research (CIHR) Project Grant 2017-2021

Canadian Institutes of Health Research (CIHR) Operating Grant 2017-2019

Crohn's & Colitis Foundation of Canada (CCFC) Grants in Aid of Research 2016-2019

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