Janis Dionne
MD, BSc, FRCPC
Investigator, BC Children's Hospital
Leung AA and Daskalopoulou SS and Dasgupta K and McBrien K and Butalia S and Zarnke KB and Nerenberg K and Harris KC and Nakhla M and Cloutier L and Gelfer M and Lamarre-Cliche M and Milot A and Bolli P and Tremblay G and McLean D and Tobe SW and Ruzicka M and Burns KD and Hypertension Canada
DOI: 10.1016/j.cjca.2017.03.005 PubMed: 2844982805 / 2017
Dionne JM and Harris KC and Benoit G and Feber J and Poirier L and Cloutier L and Nakhla M and Rabi DM and Daskalopoulou SS and Fournier A and Hypertension Canada Guideline Committee
DOI: 10.1016/j.cjca.2017.03.007 PubMed: 2844982905 / 2017
BJR Case Rep
Heran MKS, Coupal TM, Dionne J. Endovascular pharmacomechanical thrombolysis " a novel treatment for circumaortic left renal vein and inferior vena cava thrombosis in a pediatric patient with relapsing nephrotic syndrome. BJR Case Rep 2017;4(2):20170082
Springer
Dionne JM. Neonatal and Infant Hypertension. In: Flynn JT, Ingelfinger JR, Redwine K, editors. Pediatric Hypertension. 4th ed. New York, NY. Springer. Available On-line Jan 2017
Arch Dis Child
Dionne JM, Flynn JT. Management of severe hypertension in the newborn. Invited manuscript. Arch Dis Child. 2017
DOI: 10.1136/archdischild-2015-309740Pediatrics
Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, de Ferranti SD, Dionne JM, Flinn SK, Falkner B, Gidding SS, Goodwin C , Leu MG, Powers ME, Rea C, Samuels J, Simasek M, Thaker VV, Urbina EM, for the Subcommittee on Screening and Management of High Blood Pressure in Children. AAP Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. 2017 Pediatrics in press
Tarailo-Graovac M and Shyr C and Ross CJ and Horvath GA and Salvarinova R and Ye XC and Zhang LH and Bhavsar AP and Lee JJ and Drgemller BI and Abdelsayed M and Alfadhel M and Armstrong L and Baumgartner MR and Burda P and Connolly MB and Cameron J and Demos M and Dewan T and van Karnebeek CD
DOI: 10.1056/nejmoa1515792 PubMed: 2727656206 / 2016
Leung AA and Nerenberg K and Daskalopoulou SS and McBrien K and Zarnke KB and Dasgupta K and Cloutier L and Gelfer M and Lamarre-Cliche M and Milot A and Bolli P and Tremblay G and McLean D and Tobe SW and Ruzicka M and Burns KD and Valle M and Prasad GV and Lebel M and CHEP Guidelines Task Force
DOI: 10.1016/j.cjca.2016.02.066 PubMed: 2711829105 / 2016
05 / 2016
Mitsnefes MM and Pierce C and Flynn J and Samuels J and Dionne J and Furth S and Warady B and CKiD study group
DOI: 10.1007/s00467-015-3212-5 PubMed: 2641648001 / 2016
11 / 2015
BC Renal Agency
BC Renal Agency. BC Kidney Care Pediatric Renal Replacement Modality Education Module. Oct 2015 www.bcrenalagency.ca/health-professionals/clinical-resources/modality-choices
10 / 2015
Janer A and van Karnebeek CD and Sasarman F and Antonicka H and Al Ghamdi M and Shyr C and Dunbar M and Stockler-Ispiroglu S and Ross CJ and Vallance H and Dionne J and Wasserman WW and Shoubridge EA
DOI: 10.1038/ejhg.2014.293 PubMed: 2560485310 / 2015
08 / 2015
BC Renal Agency
BC Renal Agency. BC Kidney Care Guideline: Depression and Anxiety: The Role of Kidney Care Clinics. 1-32. May 2015 www.bcrenalagency.ca/health-professionals/clinical-resources/chronic-kidney-disease-(ckd)
05 / 2015
Pediatr Nephrol
Dionne JM, dAgincourt-Canning L. Sustaining life or prolonging dying? Appropriate choice of conservative care or renal replacement therapy for children in end stage kidney disease: An ethical framework. Pediatr Nephrol 30(10):1761-1769, 2015. FA
DOI: 10.1007/s00467-014-2977-2BC Renal Agency
BC Renal Agency. BC Kidney Care Guideline: Ordering, Reviewing & Follow-Up of Lab Work. 1-24. May 2013. www.bcrenalagency.ca/health-professionals/clinical-resources/chronic-kidney-disease-(ckd)
05 / 2013
J Inherit Metab Dis
Salvarinova R, Al-Thihli K, Dionne J, Kollman TR , Waters P, Langley T, Shoffner J , Stockler S, Vallance H. A novel heteroplasmic frame shift mutation in the COX2 gene leading to severe recurrent rhabdomyolysis in association with viral illness. J Inherit Metab Dis 36:S214, 2013.
J Clin Hypertens
Dionne JM, Khattab N, Glesby A, Singal M, Carr R. Hypertensive crises in children: Is it of acute or chronic origin. J Clin Hypertens 15:A74, 2013.
Pediatr Nephrol
Ajarmeh S, Er L, Brin G, Djurdjev O, Dionne JM. The effect of a multidisciplinary care clinic on the outcomes in pediatric chronic kidney disease. Pediatr Nephrol 27:1921-1927, 2012. SA
DOI: 10.1007/s00467-012-2209-6NeoReviews
Dionne JM, Flynn JT. Hypertension in the neonate. NeoReviews 13(7):e401-409, 2012. FA
Pediatr Nephrol
Dionne JM, Lou K, Er L, Collin K, White CT. Pharmaceutical cost distribution in childhood chronic kidney disease. Pediatr Nephrol 27:1531-1539, 2012. FA
DOI: 10.1007/s00467-012-2165-1Pediatr Transplant
Ebbert K, Chow J, Krempien J, Matsuda-Abedini M, Dionne J. Vitamin D insufficiency and deficiency in pediatric renal transplant patients. Pediatr Transplant 15(Suppl1):63, 2011.
Indian Pediatr
Sinha R, Dionne J. Ambulatory blood pressure monitoring in children. Indian Pediatr 48:119-122, 2011. SA
J Clin Hypertens
Lee-Son KK, Pritchard SL, Matsell DG, Chow JX, Dionne JM. Prevalence of hypertension in pediatric oncology survivors. J Clin Hypertens 13:A17, 2011.
Pediatr Nephrol
Ajarmeh S, Brin G, Er L, Djurdjev O, Dionne J. The effect of a multidisciplinary clinic on the outcomes in pediatric chronic kidney disease. Pediatr Nephrol 25:1833, 2010
Arch Dis Child
6. Sinha R, Dionne JM. Should gonadotropin releasing hormone analogue be administered to prevent premature ovarian failure in young women with systemic lupus erythematosus on cyclophosphamide therapy? Arch Dis Child 93:444-445, 2008. SA
DOI: 10.1136/adc.2007.131334Pediatr Nephrol
Sinha R, AlAbbas A, Dionne JM, Hurley RM. Simultaneous occurrence of atypical hemolytic uremic syndrome and acute lymphoblastic leukemia: A case report and literature review. Pediatr Nephrol 23:835-839, 2008. CA
DOI: 10.1007/s00467-007-0703-zJ Investig Med
AlAbbas A, Sinha R, Dionne J, Hurley R. Atypical haemolytic uremic syndrome and acute lymphoblastic leukaemia can present simultaneously. J Investig Med 56:204, 2008.
Blood Press Monit
Dionne JM, Turik MM, Hurley RM. Blood pressure abnormalities in children with chronic kidney disease. Blood Press Monit 13:205-209, 2008. FA
DOI: 10.1097/MBP.0b013e3283052fd0Growth Horm IGF Res
Bridgewater DJ, Dionne JM, Butt MJ, Pin CL, Matsell DG. The role of the type I insulin-like growth factor receptor (IGF-1R) in glomerular integrity. Growth Horm IGF Res 18:26-37, 2008. CA
DOI: 10.1016/j.ghir.2007.06.003J Pediatr
Dionne JM, Wu J, Heran M, Murphy JJ, Jevon G, White CT. Malignant hypertension, polycythemia, and paragangliomas. J Pediatr 148:540-545, 2006. FA
DOI: https://doi.org/10.1016/j.jpeds.2005.11.024Am J Kidney Dis
Dionne JM, Carter JE, Matsell D, MacNeily AE, Morrison KB, de Sa D. Renal leiomyoma associated with Epstein-Barr virus in a pediatric transplant patient. Am J Kidney Dis 46:351-355, 2005. FA
DOI: https://doi.org/10.1053/j.ajkd.2005.04.028J Mol Endocrinol
Taylor AH, Fox-Robichaud AE, Egan C, Dionne J, Lawless DE, Raymond J, Romney J, Wong NCW. Oestradiol decreases rat apolipoprotein AI transcription via promoter site B. J Mol Endocrinol 25:207-219, 2000. CA
DOI: 10.1677/jme.0.0250207J Lipid Res
Taylor AH, Raymond J, Dionne JM, Romney J, Chan J, Lawless DE, Wanke IE, Wong NCW. Glucocorticoid increases rat apolipoprotein A-I promoter activity. J Lipid Res 37:2232-2243, 1996. CA
With the assistance of a database manager, I have created a chronic kidney disease database for all pediatric patients followed at BC Children’s Hospital with a GFR of below 75 ml/min/1.73m2. We will prospectively be entering their medical information into the database to create a source of data for quality assurance studies as well as research intervention studies.
The major areas of focus of the database include renal disease progression, anemia management, renal bone disease, growth and nutrition, cardiovascular health, and morbidity and mortality. We hope to determine factors that contribute to the development or progression of abnormalities in the organ systems affected during renal failure.
On a related topic, we are joining a study by Canadian nephrologists looking at the prediction of risk of progression to dialysis or cardiovascular events or death in the chronic kidney disease population. This is a three year observational study looking at biomarkers of vascular health, inflammation, cardiac function/health and kidney dysfunction in samples of blood and urine taken at routine renal clinic visits. Outcomes identified will include initiation of renal replacement therapy, time to cardiovascular events, onset of cardiac dysfunction and death. The goal is to identify biomarkers that can predict progression of kidney disease or predict cardiac events in order to monitor or intervene if patients are identified as high risk.
24-hour ambulatory blood pressure monitoring (ABPM) has identified new ways to monitor and treat patients with hypertension. Blood pressure abnormalities that can be identified on ABPM include daytime and night-time hypertension, elevated blood pressure loads, and nocturnal blood pressure non-dipping. This non-invasive test is diagnostic for white-coat hypertension, masked hypertension, nocturnal hypertension or non-dipping, and autonomic dysfunction. Various blood pressure abnormalities are possible in patients that have received nephrotoxic medications or treatments. These patients are also at risk for permanent renal injury. Through a pediatric resident initiative, we have identified long-term survivors of childhood cancer as a group at risk for blood pressure and kidney abnormalities. In collaboration with the Oncology long-term follow-up clinic, we are going to review all patients at 5 years post-cancer diagnosis to determine if there are specific cancer diagnoses that have increased rates of clinic hypertension. Once these high-risk groups are identified, we will prospectively study blood pressure and renal function by simple methods including 24-hour ABPM, serum creatinine for estimated GFR, and urine microalbumin as a marker of renal damage. This study will determine the prevalence of renal injury and blood pressure abnormalities in long-term pediatric cancer survivors and the need for monitoring and treatment of identified issues to maintain good long-term health.
Honours in Research, Department of Medicine, University of Alberta. 2000
ASPN Trainee Basic Science Research Award, American Society of Pediatric Nephrology, 2005 The Fundamentals of Dialysis in Children: Case Conference Competition, Dialysis Annual Conference, 2005
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