Sylvia Cheng
MD, BHSc, MScCH
Investigator, BC Children's Hospital
Pediatric Blood & Cancer
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DOI: 10.1038/bjc.2011.213Journal of Pediatrics
Cheng, S.S. and Forte, V. and Shah, V.S.
DOI: 10.1016/j.jpeds.2009.01.076Central nervous system (CNS) tumors in chidlren account for a quarter of all cancers in children but diagnosis is often delayed as symptoms are not specific and more benign conditions are more common. Furthermore, the diagnosis of CNS tumors necessittes a comprehensive clinical history and complete examination in addition to advanced imaging. Delay in diagnosis of CNS tumors in children can be devastating for families and clinicians and time to diagnosis is critical in an effort to provide the best surgical and non-surgical care. Despite ample research and improvements in quality and access to diagnostic imaging, time to diagnosis in children has been less than optimal with reports of 5-8 months from time of symptom presentation to diagnosis. Therefore, we hope to retrospectively evaluate the time to diagnosis of CNS tumors in children in British Columbia with the aim of developing an algorithm and educational tools to aid health care providers in management prospectively.
Diffuse Intrinsic Pontine Glioma (DIPG) is a devastating brainstem tumor that occurs in young children. Despite attempts of novel therapeutics or conventional radiation therapy, the prognosis remains dismal. Therefore, the primary aim of the DIPG Registry is to collaborate with all pediatric centers internationally to form a clinical, radiological, and tissue repository for the basis of a platform to provide collaborative efforts and research to occur in an extremely rare disease.
Earlier generations of multi-center "Baby" protocols have demonstrated the feasibility of chemotherapy-only strategies for young children with newly diagnosed malignant brain tumors. The disease-free survivals attained with these regimens, however, remained worse compared to regimens that include radiation therapy. The previous generations of Headstart studies (1-3) demonstrated favourable outcomes for certain patient groups. Recent genomic advances in RNA and DNA profiling have identified four molecular subgroups of medulloblastoma that confer prognosis. However, all the analyses to date have been conducted on patients where the majority received radiation therapy. Therefore, the primary aims of Headstart 4 is to determine prospectively, in a randomized fashion, whether there is a difference in event-free and overall survival in those who receive a dose-intensive tandem consolidation vs. single consolidation in high risk patients with medulloblastoma and embryonal CNS tumors based on prospective molecular risk stratification.
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Pediatric centres nationwide have united to launch the DECRYPT-BABYBRAIN trial, a first-of-its-kind clinical trial that uses chemotherapy delivered to the brain to avoid radiation in treating babies and young children with aggressive brain cancer. The trial has recruited its first six participants, with enrollment now open at The Hospital for Sick Children (SickKids) in Toronto,…
Central nervous system (CNS) tumours are growths of abnormal cells residing in either the brain or spinal cord. Not all tumours are necessarily cancerous; if a tumour lacks the ability to spread to other tissues then it is considered non-cancerous (benign). However, even benign tumours can still be dangerous in the brain or spinal cord…
For the first couple years of his life growing up in Syria, Ebrahim Aldalati was, as he put it, “a regular baby.” He had no health issues and was just like other kids. But by the time he was two, that all changed.
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