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Glen F. Tibbits
BEd, MSc, PhD

Investigator, BC Children's Hospital
Canada Research Chair in Molecular Cardiac Physiology (2004-2018)

Although the neonate heart is completely responsible for delivering blood to the body, it is still immature in many respects. This is particularly true of the cardiac contractile system and its regulatory mechanisms. The strength of cardiac contraction is determined by the amount of calcium (Ca2+) delivered to the contractile element. Thus the levels of Ca2+ inside each cell (or cardiomyocyte) rise and fall each beat, and peak value can vary substantially in response to physiological needs and/or hormones such as adrenaline. How this is achieved in the neonate heart, although poorly understood, is quite different from the adult heart. This has clinical implications; for example, in children with congenital heart disease (present in 1% of live births), the heart must often be arrested during surgical correction. However, these techniques are largely derived from our understanding of the adult heart. We hope to improve the success rate of surgical correction, and better understand “normal” heart development and the deviations that occur in congenital heart diseases.

Academic Affiliations

  • Adjunct Professor, , Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia
  • Professor, , Department of Biomedical Physiology and Kinesiology, Faculty of Science, Simon Fraser University
  • Professor, , Department of Molecular Biology and Biochemistry, Faculty of Science, Simon Fraser University
  • Affiliate Professor, , School of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases

Contact Information

Assistant

Jing Wang

jingwang@mail.ubc.ca

Location

950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4

(604) 875-2000 ext. 6508

tibbits@sfu.ca

Versatile hiPSC Models and Bioengineering Platforms for Investigation of Atrial Fibrosis and Fibrillation

Cells

Behnam Panahi and Saif Dababneh and Saba Fadaei and Hosna Babini and Sanjana Singh and Maksymilian Prondzynski and Mohsen Akbari and Peter H. Backx and Jason G. Andrade and Robert A. Rose and Glen F. Tibbits

DOI: 10.3390/cells15020187

01 / 2026

Electrophysiological Phenotyping of hiPSC-Derived Atrial Cardiomyocytes Using Automated Patch-Clamp: A Platform for Studying Atrial Inherited Arrhythmias

Cells

Vernica Jimnez-Sbado and Hosna Babini and Peter C. Ruben and Eric A. Accili and Thomas W. Claydon and Leif Hove-Madsen and Glen F. Tibbits

DOI: 10.3390/cells14241941

12 / 2025

Conservation and divergence of transcriptional heterogeneity in the cardiac conduction system

Marwan Bakr and Saif Dababneh and Glen F. Tibbits and Yena Oh and Kyoung-Han Kim

DOI: 10.1101/2025.09.23.678069

09 / 2025

Dissecting cardiovascular disease-associated noncoding genetic variants using human iPSC models

Stem Cell Reports

Saif F. Dababneh and Hosna Babini and Vernica Jimnez-Sbado and Sheila S. Teves and Kyoung-Han Kim and Glen F. Tibbits

DOI: 10.1016/j.stemcr.2025.102467

04 / 2025

Developing a soft micropatterned substrate to enhance maturation of human induced pluripotent stem cell-derived cardiomyocytes

Acta Biomaterialia

Yasaman Maaref and Shayan Jannati and Farah Jayousi and Philipp Lange and Mohsen Akbari and Mu Chiao and Glen F Tibbits

DOI: 10.1016/j.actbio.2024.10.029

12 / 2024

The effect of Mg2+ on Ca2+ binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants

The FEBS Journal

Kaveh Rayani and Eric R. Hantz and Omid Haji-Ghassemi and Alison Y. Li and Anne M. Spuches and Filip Van Petegem and R. John Solaro and Steffen Lindert and Glen F. Tibbits

DOI: 10.1111/febs.16578

12 / 2022

Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243

Journal of General Physiology

Jacob M. Kemp and Dominic G. Whittaker and Ravichandra Venkateshappa and ZhaoKai Pang and Raj Johal and Valentine Sergeev and Glen F. Tibbits and Gary R. Mirams and Thomas W. Claydon

DOI: 10.1085/jgp.202112923

10 / 2021

The effect of magnesium on calcium binding to cardiac troponin C related hypertrophic cardiomyopathy mutants

Kaveh Rayani and Eric Hantz and Omid Haji-Ghassemi and Alison Yueh Li and Anne Marie Spuches and Filip Van Petegem and R John Solaro and Steffen Lindert and Glen F Tibbits

DOI: 10.1101/2021.05.12.443789

05 / 2021

Binding of calcium and magnesium to human cardiac troponin C

Journal of Biological Chemistry

Kaveh Rayani and Justin Seffernick and Alison Yueh Li and Jonathan P. Davis and Anne Marie Spuches and Filip Van Petegem and R. John Solaro and Steffen Lindert and Glen F. Tibbits

DOI: 10.1016/j.jbc.2021.100350

01 / 2021

Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping

STEM CELLS Translational Medicine

Marvin G. Gunawan and Sarabjit S. Sangha and Sanam Shafaattalab and Eric Lin and Danielle A. Heims-Waldron and Vassilios J. Bezzerides and Zachary Laksman and Glen F. Tibbits

DOI: 10.1002/sctm.19-0440

01 / 2021

Binding of Calcium and Magnesium to Cardiac Troponin C

K Rayani and JT Seffernick and YA Li and JP Davis and AM Spuches and F Van Petegem and RJ Solaro and S Lindert and GF Tibbits

DOI: 10.1101/2020.06.14.150854

06 / 2020

In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm

Scientific Reports

Jason Z. Cui and Ling Lee and Xiaoye Sheng and Fanny Chu and Christine P. Gibson and Taline Aydinian and David C. Walker and George G. S. Sandor and Pascal Bernatchez and Glen F. Tibbits and Cornelis van Breemen and Mitra Esfandiarei

DOI: 10.1038/s41598-018-38235-6

02 / 2019

Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue

Scientific Reports

Zachary Laksman and Marianne Wauchop and Eric Lin and Stephanie Protze and Jeehoon Lee and Wallace Yang and Farzad Izaddoustdar and Sanam Shafaattalab and Lior Gepstein and Glen F. Tibbits and Gordon Keller and Peter H. Backx

DOI: 10.1038/s41598-017-05652-y

07 / 2017

Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations

Journal of Biological Chemistry

Charles M. Stevens and Kaveh Rayani and Gurpreet Singh and Bairam Lotfalisalmasi and D.Peter Tieleman and Glen F. Tibbits

DOI: 10.1074/jbc.M116.770776

07 / 2017

Erratum: Functional Assessment of Cardiac Responses of Adult Zebrafish (Danio rerio) to Acute and Chronic Temperature Change Using High-Resolution Echocardiography (PLoS ONE (2016) 11:1 (e0145163) DOI: 10.1371/journal.pone.0145163)

PLoS ONE

Lee, L. and Genge, C.E. and Cua, M. and Sheng, X. and Rayani, K. and Beg, M.F. and Sarunic, M.V. and Tibbits, G.F.

DOI: 10.1371/journal.pone.0149741

Functional assessment of cardiac responses of adult zebrafish (danio rerio) to acute and chronic temperature change using high-resolution echocardiography

PLoS ONE

Lee, L. and Genge, C.E. and Cua, M. and Sheng, X. and Rayani, K. and Beg, M.F. and Sarunic, M.V. and Tibbits, G.F.

DOI: 10.1371/journal.pone.0145163

Construction and use of a zebrafish heart voltage and calcium optical mapping system, with integrated electrocardiogram and programmable electrical stimulation

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Lin, E. and Craig, C. and Lamothe, M. and Sarunic, M.V. and Beg, M.F. and Tibbits, G.F.

DOI: 10.1152/ajpregu.00001.2015.

Automatic cycle averaging for denoising approximately periodic spatiotemporal signals

IEEE Transactions on Medical Imaging

Ding, W. and Lin, E. and Ribeiro, A. and Sarunic, M.V. and Tibbits, G.F. and Beg, M.F.

DOI: 10.1109/TMI.2014.2323201

Optical mapping of the electrical activity of isolated adult zebrafish hearts: Acute effects of temperature

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Lin, E. and Ribeiro, A. and Ding, W. and Hove-Madsen, L. and Sarunic, M.V. and Beg, M.F. and Tibbits, G.F.

DOI: 10.1152/ajpregu.00002.2014

Morphological phenotyping of mouse hearts using optical coherence tomography

Journal of Biomedical Optics

Cua, M. and Lin, E. and Lee, L. and Sheng, X. and Wong, K.S.K. and Tibbits, G.F. and Beg, M.F. and Sarunic, M.V.

DOI: 10.1117/1.JBO.19.11.116007

Adult teleost heart expresses two distinct troponin C paralogs: Cardiac TnC and a novel and teleost-specific ssTnC in a chamber- and temperature-dependent manner

Physiological Genomics

Genge, C.E. and Davidson, W.S. and Tibbits, G.F.

DOI: 10.1152/physiolgenomics.00074.2013

Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I

PLoS ONE

Li, A.Y. and Stevens, C.M. and Liang, B. and Rayani, K. and Little, S. and Davis, J. and Tibbits, G.F.

DOI: 10.1371/journal.pone.0079363

The structure of cardiac troponin C regulatory domain with bound Cd 2+ reveals a closed conformation and unique ion coordination

Acta Crystallographica Section D: Biological Crystallography

Zhang, X.L. and Tibbits, G.F. and Paetzel, M.

DOI: 10.1107/S0907444913001182

On identification of sinoatrial node in zebrafish heart based on functional time series from optical mapping

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Ding, W. and Lin, E. and Ribeiro, A. and Sarunic, M.V. and Tibbits, G.F. and Beg, M.F.

DOI: 10.1109/EMBC.2013.6611048

Isolation and characterization of atrioventricular nodal cells from neonate rabbit heart

Circulation: Arrhythmia and Electrophysiology

Sheng, X.Y. and Qu, Y. and Dan, P. and Lin, E. and Korthout, L. and Bradford, A. and Hove-Madsen, L. and Sanatani, S. and Tibbits, G.F.

DOI: 10.1161/CIRCEP.111.964056

Colocalization of voltage-gated Na+ channels with the Na +/Ca2+ exchanger in rabbit cardiomyocytes during development

American Journal of Physiology - Heart and Circulatory Physiology

Gershome, C. and Lin, E. and Kashihara, H. and Hove-Madsen, L. and Tibbits, G.F.

DOI: 10.1152/ajpheart.00798.2010

Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation

Journal of Molecular Biology

Li, A.Y. and Lee, J. and Borek, D. and Otwinowski, Z. and Tibbits, G.F. and Paetzel, M.

DOI: 10.1016/j.jmb.2011.08.049

Calcium handling in zebrafish ventricular myocytes

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Zhang, P.-C. and Llach, A. and Sheng, X.Y. and Hove-Madsen, L. and Tibbits, G.F.

DOI: 10.1152/ajpregu.00377.2010

Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of iks

Journal of General Physiology

Eldstrom, J. and Xu, H. and Werry, D. and Kang, C. and Loewen, M.E. and Degenhardt, A. and Sanatani, S. and Tibbits, G.F. and Sanders, C. and Fedida, D.

DOI: 10.1085/jgp.200910351

Characterization of zebrafish (Danio rerio) NCX4: A novel NCX with distinct electrophysiological properties

American Journal of Physiology - Cell Physiology

On, C. and Marshall, C.R. and Perry, S.F. and Hoa, D.L. and Yurkov, V. and Omelchenko, A. and Hnatowich, M. and Hryshko, L.V. and Tibbits, G.F.

DOI: 10.1152/ajpcell.00455.2008

Distribution patterns of the Na+-Ca2+ exchanger and caveolin-3 in developing rabbit cardiomyocytes

Cell Calcium

Lin, E. and Hung, V.H.Y. and Kashihara, H. and Dan, P. and Tibbits, G.F.

DOI: 10.1016/j.ceca.2009.01.001

Ontogeny of Ca2+-induced Ca2+ release in rabbit ventricular myocytes

American Journal of Physiology - Cell Physiology

Huang, J. and Hove-Madsen, L. and Tibbits, G.F.

DOI: 10.1152/ajpcell.00417.2007

Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells

Journal of Physiology

Qu, Y. and Whitaker, G.M. and Hove-madsen, L. and Tibbits, G.F. and Accili, E.A.

DOI: 10.1113/jphysiol.2007.144329

Gene structure evolution of the Na+-Ca2+ exchanger (NCX) family

BMC Evolutionary Biology

On, C. and Marshall, C.R. and Chen, N. and Moyes, C.D. and Tibbits, G.F.

DOI: 10.1186/1471-2148-8-127

Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility

Physiological Genomics

Liang, B. and Chung, F. and Qu, Y. and Pavlov, D. and Gillis, T.E. and Tikunova, S.B. and Davis, J.P. and Tibbits, G.F.

DOI: 10.1152/physiolgenomics.00154.2007

A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: A community-based approach to understanding the impact

Genetics in Medicine

Arbour, L. and Rezazadeh, S. and Eldstrom, J. and Weget-Simms, G. and Rupps, R. and Dyer, Z. and Tibbits, G. and Accili, E. and Casey, B. and Kmetic, A. and Sanatani, S. and Fedida, D.

DOI: 10.1097/GIM.0b013e31817c6b19

Functional and evolutionary relationships of troponin C

Physiological Genomics

Gillis, T.E. and Marshall, C.R. and Tibbits, G.F.

DOI: 10.1152/physiolgenomics.00197.2007

SR Ca2+ refilling upon depletion and SR Ca2+ uptake rates during development in rabbit ventricular myocytes

American Journal of Physiology - Cell Physiology

Huang, J. and Hove-Madsen, L. and Tibbits, G.F.

DOI: 10.1152/ajpcell.00241.2007

Real-time monitoring of intracellular calcium dynamic mobilization of a single cardiomyocyte in a microfluidic chip pertaining to drug discovery

Electrophoresis

Li, X. and Huang, J. and Tibbits, G.F. and Li, P.C.H.

DOI: 10.1002/elps.200700312

Three-dimensional distribution of cardiac Na+-Ca2+ exchanger and ryanodine receptor during development

Biophysical Journal

Dan, P. and Lin, E. and Huang, J. and Biln, P. and Tibbits, G.F.

DOI: 10.1529/biophysj.107.104943

L-type Ca2+ channel function and expression in neonatal rabbit ventricular myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Huang, J. and Xu, L. and Thomas, M. and Whitaker, K. and Hove-Madsen, L. and Tibbits, G.F.

DOI: 10.1152/ajpheart.01093.2005

Store-operated Ca2+ entry modulates sarcoplasmic reticulum Ca2+ loading in neonatal rabbit cardiac ventricular myocytes

American Journal of Physiology - Cell Physiology

Huang, J. and Van Breemen, C. and Kuo, K.-H. and Hove-Madsen, L. and Tibbits, G.F.

DOI: 10.1152/ajpcell.00226.2005

Increasing mammalian cardiomyocyte contractility with residues identified in trout troponin C

Physiological Genomics

Gillis, T.E. and Liang, B. and Chung, F. and Tibbits, G.F.

DOI: 10.1152/physiolgenomics.00007.2005

CDNA cloning and expression of the cardiac Na+/Ca2+ exchanger from mozambique tilapia (Oreochromis mossambicus) reveal a teleost membrane transporter with mammalian temperature dependence

Journal of Biological Chemistry

Marshall, C.R. and Pan, T.-C. and Le, H.D. and Omelchenko, A. and Hwang, P.P. and Hryshko, L.V. and Tibbits, G.F.

DOI: 10.1074/jbc.M504807200

Phylogeny of Na+/Ca2+ exchanger (NCX) genes from genomic data identifies new gene duplications and a new family member in fish species

Physiological Genomics

Marshall, C.R. and Fox, J.A. and Butland, S.L. and Ouellette, B.F.F. and Brinkman, F.S.L. and Tibbits, G.F.

DOI: 10.1152/physiolgenomics.00286.2004

Na+/Ca2+ exchange activity in neonatal rabbit ventricular myocytes

American Journal of Physiology - Cell Physiology

Huang, J. and Hove-Madsen, L. and Tibbits, G.F.

DOI: 10.1152/ajpcell.00183.2004

Deconvolution of confocal images of dihydropyridine and ryanodine receptors in developing cardiomyocytes

Journal of Applied Physiology

Sedarat, F. and Lin, E. and Moore, E.D.W. and Tibbits, G.F.

DOI: 10.1152/japplphysiol.00089.2004

Effect of -adrenergic stimulation on the relationship between membrane potential, intracellular [Ca2+] and sarcoplasmic reticulum Ca2+ uptake in rainbow trout atrial myocytes

Journal of Experimental Biology

Llach, A. and Huang, J. and Sederat, F. and Tort, L. and Tibbits, G. and Hove-Madsen, L.

DOI: 10.1242/jeb.00884

Effect of Temperature on the Structure of Trout Troponin C

Biochemistry

Blumenschein, T.M.A. and Gillis, T.E. and Tibbits, G.F. and Sykes, B.D.

DOI: 10.1021/bi035504z

Sequence mutations in teleost cardiac troponin C that are permissive of high Ca2+ affinity of site II

American Journal of Physiology - Cell Physiology

Gillis, T.E. and Moyes, C.D. and Tibbits, G.F.

Effect of temperature and the F27W mutation on the Ca2+ activated structural transition of trout cardiac troponin C

Biochemistry

Gillis, T.E. and Blumenschein, T.M.A. and Sykes, B.D. and Tibbits, G.F.

DOI: 10.1021/bi0340494

Triggering of sarcoplasmic reticulum Ca2+ release and contraction by reverse mode Na+/Ca2+ exchange in trout atrial myocytes

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Hove-Madsen, L. and Llach, A. and Tibbits, G.F. and Tort, L.

Na+/H+ exchange inhibition with HOE 642 improves recovery of the injured neonatal rabbit heart

Canadian Journal of Cardiology

Sett, S.S. and Galanopoulos, P.T. and Kashihara, H. and Talling, D.N. and LeBlanc, J.G. and Tibbits, G.F.

Temperature dependence of cardiac Na+/Ca2+ exchanger

Annals of the New York Academy of Sciences

Marshall, C. and Elias, C. and Xue, X.-H. and Le, H.D. and Omelchenko, A. and Hryshko, L.V. and Tibbits, G.F.

Determinants of cardiac Na+/Ca2+ exchanger temperature dependence: NH2-terminal transmembrane segments

American Journal of Physiology - Cell Physiology

Marshall, C. and Elias, C. and Xue, X.-H. and Le, H.D. and Omelchenko, A. and Hryshko, L.V. and Tibbits, G.F.

Beating the cold: The functional evolution of troponin C in teleost fish

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Gillis, T.E. and Tibbits, G.F.

DOI: 10.1016/S1095-6433(02)00046-6

Ontogeny of excitation - Contraction coupling in the mammalian heart

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Tibbits, G.F. and Xu, L. and Sedarat, F.

DOI: 10.1016/S1095-6433(02)00128-9

Temperature dependence of cloned mammalian and salmonid cardiac NA+/CA2+ exchanger isoforms

American Journal of Physiology - Cell Physiology

Elias, C.L. and Xue, X.-H. and Marshall, C.R. and Omelchenko, A. and Hryshko, L.V. and Tibbits, G.F.

Effects of diabetes and hypertension on myocardial Na+-Ca2+ exchange

Canadian Journal of Physiology and Pharmacology

Kashihara, H. and Shi, Z.Q. and Yu, J.Z. and McNeill, J.H. and Tibbits, G.F.

Evolutionary and physiological variation in cardiac troponin C in relation to thermal strategies of fish

Physiological and Biochemical Zoology

Yang, H. and Velema, J. and Hedrick, M.S. and Tibbits, G.F. and Moyes, C.D.

DOI: 10.1086/318095

Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy

American Journal of Physiology - Heart and Circulatory Physiology

Sedarat, F. and Xu, L. and Moore, E.D.W. and Tibbits, G.F.

Ca2+ binding to cardiac troponin C: Effects of temperature and pH on mammalian and salmonid isoforms

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Gillis, T.E. and Marshall, C.R. and Xue, X.-H. and Borgford, T.J. and Tibbits, G.F.

Cloning, expression, and characterization of the trout cardiac Na+/Ca2+ exchanger

American Journal of Physiology - Cell Physiology

Xue, X.-H. and Hryshko, L.V. and Nicoll, D.A. and Philipson, K.D. and Tibbits, G.F.

Cloning and sequencing of complementary DNA for fatty acid binding protein from rainbow trout heart

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

Ando, S. and Xue, X.-H. and Tibbits, G.F. and Haunerland, N.H.

DOI: 10.1016/S0305-0491(97)00309-X

Cloning and expression of salmon cardiac troponin C: Titration of the low-affinity Ca2+-binding site using a tryptophan mutant

Biochemistry

Moyes, C.D. and Borgford, T. and LeBlanc, L. and Tibbits, G.F.

DOI: 10.1021/bi9607057

Dihydropyridine and ryanodine binding in ventricles from rat, trout, dogfish and hagfish

Journal of Experimental Biology

Thomas, M.J. and Hamman, B.N. and Tibbits, G.F.

Effects of doxorubicin, 4'-epirubicin, and antioxidant enzymes on the contractility of isolated cardiomyocytes

Canadian Journal of Physiology and Pharmacology

Chan, E.M. and Thomas, M.J. and Bandy, B. and Tibbits, G.F.

DOI: 10.1139/cjpp-74-8-904

Towards a molecular explanation of the high performance of the tuna heart

Comparative Biochemistry and Physiology - A Physiology

Tibbits, G.F.

DOI: 10.1016/0300-9629(95)02055-1

cGMP elevation does not mediate muscarinic agonist-induced negative inotropy in rat ventricular cardiomyocytes

American Journal of Physiology - Heart and Circulatory Physiology

MacDonell, K.L. and Tibbits, G.F. and Diamond, J.

Cellular functions of diabetic cardiomyocytes: Contractility, rapid- cooling contracture, and ryanodine binding

American Journal of Physiology - Heart and Circulatory Physiology

Yu, Z. and Tibbits, G.F. and McNeill, J.H.

Effect of temperature and temperature acclimation on the ryanodine sensitivity of the trout myocardium

Journal of Comparative Physiology B

Keen, J.E. and Vianzon, D.-M. and Farrell, A.P. and Tibbits, G.F.

DOI: 10.1007/BF00714580

Temperature and pH effects on Ca2+ sensitivity of cardiac myofibrils: A comparison of trout with mammals

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Churcott, C.S. and Moyes, C.D. and Bressler, B.H. and Baldwin, K.M. and Tibbits, G.F.

Temperature dependence of unitary properties of an ATP-dependent potassium channel in cardiac myocytes

Biophysical Journal

McLarnon, J.G. and Hamman, B.N. and Tibbits, G.F.

6 Excitation-Contraction Coupling in the Teleost Heart

Fish Physiology

Tibbits, G.F. and Moyes, C.D. and Hove-Madsen, L.

DOI: 10.1016/S1546-5098(08)60336-2

Characterization of myocardial Na+-Ca2+ exchange in rainbow trout

American Journal of Physiology - Cell Physiology

Tibbits, G.F. and Philipson, K.D. and Kashihara, H.

Regulation of myocardial contractility

Medicine and Science in Sports and Exercise

Tibbits, G.F. and Hamman, B.N.

Ca2+ transport in myocardial sarcolemma from rainbow trout

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Tibbits, G.F. and Kashihara, H. and Thomas, M.J. and Keen, J.E. and Farrell, A.P.

Ca<sup>2+</sup> transport across the plasma membrane of striated muscle

Medicine and Science in Sports and Exercise

Tibbits, G.F. and Thomas, M.J.

Effects of active oxygen generated by DTT Fe2+ on cardiac Na+ Ca2+ exchange and membrane permeability to Ca2+

Journal of Molecular and Cellular Cardiology

Shi, Z.Q. and Davison, A.J. and Tibbits, G.F.

DOI: 10.1016/0022-2828(89)90799-2

Na+-Ca2+ exchange in cardiac sarcolemma: modulation of Ca2+ affinity by exercise.

The American journal of physiology

Tibbits, G.F. and Kashihara, H. and O'Reilly, K.

Na+-Ca2+ exchange in cardiac sarcolemma: Modulation of Ca2+ affinity by exercise

American Journal of Physiology - Cell Physiology

Tibbits, G.F. and Kashihara, H. and O'Reilly, K.

Active oxygen in neuromuscular disorders

Molecular and Cellular Biochemistry

Davison, A. and Tibbits, G. and Shi, Z. and Moon, J.

DOI: 10.1007/BF00421055

The effect of activity on calcium-mediated events in striated muscle

Exercise and Sport Sciences Reviews

Klug, G.A. and Tibbits, G.F.

Na+-dependent alkaline earth metal uptake in cardiac sarcolemmal vesicles

BBA - Biomembranes

Tibbits, G.F. and Philipson, K.D.

DOI: 10.1016/0005-2736(85)90035-5

Regulation of myocardial contractility in exhaustive exercise

Medicine and Science in Sports and Exercise

Tibbits, G.F.

Cardiac sarcolemma: Compositional adaptation to exercise

Science

Tibbits, G.F. and Nagatomo, T. and Sasaki, M. and Barnard, R.J.

Influence of exercise on excitation-contraction coupling in rat myocardium

American Journal of Physiology - Heart and Circulatory Physiology

Tibbits, G.F. and Barnard, R.J. and Baldwin, K.M.

Influence of exercise on excitation-contraction coupling in rat myocardium.

The American journal of physiology

Tibbits, G.F. and Barnard, R.J. and Baldwin, K.M. and Cugalj, N. and Roberts, N.K.

Characterization of rat myocardial sarcolemma

Journal of Molecular and Cellular Cardiology

Tibbits, G.F. and Sasaki, M. and Ikeda, M. and Shimada, K. and Tsuruhara, T. and Nagatomo, T.

DOI: 10.1016/0022-2828(81)90295-9

Adaptation of the rat myocardium to endurance training

Journal of Applied Physiology Respiratory Environmental and Exercise Physiology

Tibbits, G. and Koziol, B.J. and Roberts, N.K. and Baldwin, K.M. and Barnard, R.J.

Regulation of cardiac myofilament sensitivity to calcium

Heart and Stroke Foundation funded project that addresses the structure function relationship of troponin C and its ability to bind Ca2+, a primary determinant of cardiac contractility. The research involves making mutations of troponin C and understanding how the structural changes that result affect Ca2+ binding to the regulatory domain of the molecule. Information from this project will be directed to the development of a novel class of Ca2+-senstizing drugs which may be used to treat heart failure.

Ontogeny of myocardial excitation- contraction coupling mechanisms

CIHR funded project with the objectives of determining the molecular and cellular changes in cardiomyocytes from the earliest stages post-partum until adulthood with an eye to understanding certain congenital heart diseases.

Molecular mechanisms of electrogenesis in the neonate heart

CIHR funded project focusing on the molecular and cellular mechansms of junctional ectopic tachycardia (JET). JET is an arrhythmia that occurs with relatively high frequency in neonates after open heart surgery. The etiology of JET is poorly understood and as a consequence existing treatments are non-specific and often lack efficacy.

Grants

NSERC Discovery Grant - Project: "Regulation of contractility in the teleost heart" (2014)

Honours & Awards

Tier I Canada Research Chair in Molecular Cardiac Physiology

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BC Children's Hospital Research Institute operates on the ancestral and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. Further, this acknowledgement, gratitude, and respect extends to all of the First Nations communities on whose territories the Research Institute builds relationships and operates in British Columbia.

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