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Bruce Verchere

PhD

Investigator, BC Children's Hospital
Director, Centre for Molecular Medicine and Therapeutics
Childhood Diabetes Laboratories, BC Children’s Hospital
Irving K Barber Chair in Diabetes Research

In diabetes mellitus the pancreas' insulin-producing beta cells have impaired function or are destroyed, resulting in deficient insulin secretion. This leads to high blood glucose levels and later complications, including kidney disease and blindness. In type 1 (juvenile onset) diabetes the patient's own immune system kills the beta cells. In type 2 (adult onset) diabetes, the body is less sensitive to insulin produced, and the beta cells cannot secrete enough insulin to compensate. Over time, insulin secretion declines, probably due to a progressive loss of beta cells from the toxic effects of elevated blood glucose as well as the accumulation of protein-containing deposits called islet amyloid. We are trying to understand how beta cells normally function and why they are dysfunctional and/or are destroyed in both types of diabetes. We hope to devise new ways to protect beta cells, thereby slowing or preventing disease onset, and to enhance beta cell survival following transplantation of pancreatic islets into diabetic patients.

Bruce Verchere

PhD

Investigator, BC Children's Hospital Director, Centre for Molecular Medicine and Therapeutics Childhood Diabetes Laboratories, BC Children’s Hospital Irving K Barber Chair in Diabetes Research

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a cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?

Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction

ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression

Reawakening the Duct Cell Progenitor?

Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates

CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

Amyloid Formation in Human Islets Is Enhanced by Heparin and Inhibited by Heparinase

Cellular Mechanisms of CCL22-Mediated Attenuation of Autoimmune Diabetes

Loss of Cyp8b1 Improves Glucose Homeostasis by Increasing GLP-1

Islet Remodeling in Female Mice with Spontaneous Autoimmune and Streptozotocin-Induced Diabetes

Thioredoxin-interacting Protein Promotes Islet Amyloid Polypeptide Expression through miR-124a and FoxA2

IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice

Resident Macrophages Mediate Islet Amyloid Polypeptide"Induced Islet IL-1 Production and -Cell Dysfunction

Endogenous Expression of B7-H4 Improves Long-term Murine Islet Allograft Survival

Activating the NLRP3 Inflammasome Using the Amyloidogenic Peptide IAPP

Death and Dysfunction of Transplanted -Cells: Lessons Learned From Type 2 Diabetes?

Endogenous Expression of B7-H4 Improves Long Term Murine Islet Allograft Survival

Metabolic stress, IAPP and islet amyloid

Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival

TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells

Translational Control of Glucose-Induced Islet Amyloid Polypeptide Production in Pancreatic Islets

miR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired -Cell Function

B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation

B7-H4 Induces Donor-Specific Tolerance in Mouse Islet Allografts

Reverse engineering an amyloid aggregation pathway with dimensional analysis and scaling

Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes

Altered Glutathione Homeostasis in Heart Augments Cardiac Lipotoxicity Associated with Diet-induced Obesity in Mice

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

Kinetics and genomic profiling of adult human and mouse -cell maturation

Improving Islet Engraftment by Gene Therapy

B7-H4 Pathway in Islet Transplantation and-Cell Replacement Therapies

Advances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation

The Flavanol (-)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

Cholesterol toxicity in pancreatic islets from LDL receptor-deficient mice. Reply to: de Souza JC, de Oliveira CAM, Carneiro EM et al. [letter]

Selecting exercise regimens and strains to modify obesity and diabetes in rodents: an overview

T REGULATORY CELL MEDIATED PROTECTION OF ALLOGRAFT IN TYPE 1 DIABETES

The Sulfated Triphenyl Methane Derivative Acid Fuchsin Is a Potent Inhibitor of Amyloid Formation by Human Islet Amyloid Polypeptide and Protects against the Toxic Effects of Amyloid Formation

HDL and LDL cholesterol significantly influence -cell function in type 2 diabetes mellitus

Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice

Role of the TLR signaling molecule TRIF in-cell function and glucose homeostasis

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

Cholesterol in -cell Dysfunction: The Emerging Connection Between HDL Cholesterol and Type 2 Diabetes

XIAP inhibition of -cell apoptosis reduces the number of islets required to restore euglycemia in a syngeneic islet transplantation model

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Pancreatic islet transplantation

Immune-mediated beta cell death in type 1 diabetes

Islet amyloid and type 2 diabetes

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Investigator, BC Children's Hospital
Director, Centre for Molecular Medicine and Therapeutics
Childhood Diabetes Laboratories, BC Children’s Hospital
Irving K Barber Chair in Diabetes Research