Daniel Leung
MD, MSc
Investigator, BC Children's Hospital
Reconstructing pathogen-specific antibody binding epitopes and age-dependent immune signatures from proteomic-scale peptide libraries
Science Advances
John Shon and Andrew Mertens and Richelle C Charles and Md. Ziaur Rahman and Abul Kasham Md. Shoab and MohammadSaheen Hossen and Palash Mutsuddi and Syeda Famida and Salma Akther and Audrie Lin and Shahjahan Ali and Benjamin F Arnold and Mahbubur Rahman and Stephen P. Luby and Daniel Leung and Nikolina Walas and Minlu Zhang and Jack Reifert and Everlyn Kamau and Kathy Kamath and Jessica Grembi
DOI: 10.1126/sciadv.aec547808 / 2026
Derivation and validation of clinical prediction models for Cryptosporidium-attributed acute diarrhea in African children
Daniel T. Leung and Lna Mazza and Ben Brintz and M. Jahangir Hossain and Billy Ogwel and John B. Ochieng and Jane Juma and Helen Powell and Adama Mamby Keita and Richard Omore and Samba Sow and Karen Kotloff and James Platts-Mills and Andrew T. Pavia
DOI: 10.1093/infdis/jiag36207 / 2026
Hantavirus infection in returned travellers: data from the GeoSentinel network
Journal of Travel Medicine
Isaac I Bogoch and Sapha Barkati and Marta Daz-Menndez and Loc Epelboin and Daniel T Leung and Shaun K Morris and Francesca F Norman and Robert J Rolfe and Stephen D Vaughan and Kevin OLaughlin and Michael Libman and Rinki Goswami
DOI: 10.1093/jtm/taag06207 / 2026
Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal-Associated Invariant T (MAIT) Cell Function
Immunology
Olivia J. Cheng and Eimear K. Ryan and Michael Bennett and Christy Clutter and Jackson G. Cacioppo and Jeffrey Aub and Andy E. Hogan and Daniel T. Leung
DOI: 10.1111/imm.7008605 / 2026
Global Detection of Respiratory Illness Outbreaks in Travelers: A Statistical Approach using GeoSentinel Data, 2015"2024
Stan Heidema and Ivo V. Stoepker and Daniel T. Leung and Watcharapong Piyaphanee and Lin H. Chen and Marta Daz-Menndez and Kevin OLaughlin and Michael Libman and Davidson H. Hamer and Edwin R. van den Heuvel and Ralph Huits
DOI: 10.64898/2026.05.06.2635253405 / 2026
Development and External Validation of a Prognostic Prediction Model for Hospitalization in SARS-CoV-2-Infected Ambulatory Patients
Open Forum Infectious Diseases
Robert J Williams and Ben J Brintz and Nancy Grisel and Josh V Otterloo and Autumn Kieber-Emmons and Mark Ebell and Daniel T Leung and Bert K Lopansri
DOI: 10.1093/ofid/ofag22604 / 2026
Tracing MR1 expression across tissues to find the perfect MAIT
Journal of Leukocyte Biology
Christy H Clutter and Daniel T Leung
DOI: 10.1093/jleuko/qiag01402 / 2026
Quantifying the population-level impact of expanded antibiotic treatment for cholera outbreak management
PLOS Computational Biology
Sharia M. Ahmed and Claudio Jos Struchiner and Cormac R. LaPrete and Iza Ciglenecki and Andrew Azman and Daniel T. Leung and Lindsay T. Keegan
DOI: 10.1371/journal.pcbi.101398002 / 2026
Estrogen Induced Regulation of Mucosal-Associated Invariant T Cells in Asthma
Journal of Immunology Research
Shubhanshi Trivedi and Samuel E. Aamodt and Thomas P. Huecksteadt and Elizabeth J. Myers and Grace Helen McGee and Jackson G. Cacioppo and Jeffrey Aub and Robert Paine, III and Daniel T. Leung and Kristi J. Warren and Poorani Gurumallesh Prabu
DOI: 10.1155/jimr/820192301 / 2026
Longitudinal Changes in Nasal and Oral Microbiome and Antimicrobial Resistance Gene Profiles in Response to Human Fecal Microbiota Transplantation
Mary L. Vallecillo-Zuniga and Ali Akeefe and D. Garrett Brown and Taylor A. Wahlig and Marco Marchetti and Tatum Heiner and Kilee L. Davis and Carmen Nieznanski and Ann Flynn and Daniel T. Leung
DOI: 10.64898/2026.01.27.70185401 / 2026
Immune checkpoint expression in mucosal-associated invariant T cells is stimulus-dependent
Journal of Leukocyte Biology
Christy H Clutter and Audrey Re and Kenadee Jacobson and Kendell Clement and Jeffrey Aub and Ryan M OConnell and Daniel T Leung
DOI: 10.1093/jleuko/qiaf17712 / 2025
Long-Term Antibody Responses to Vibrio cholerae Across Natural Infection, Vaccination, and Challenge: A Systematic Review
Aparna Mangadu and Christy Clutter and Kenadee Jacobson and Tatum Heiner and Shubhanshi Trivedi and Md. Saruar Bhuiyan and Ben J Brintz and Andrew S. Azman and Benjamin F. Arnold and Daniel T. Leung
DOI: 10.64898/2025.11.27.2534115712 / 2025
Long-term Kinetics of Vibriocidal Antibody Responses After Vibrio cholerae Infection in the Democratic Republic of Congo
The Journal of Infectious Diseases
Kilee L Davis and Carmen Nieznanski and Felicien M Maisha and Ben J Brintz and Christy H Clutter and Meer T Alam and Cyrus Saleem and Afsar Ali and J Glenn Morris and Daniel T Leung
DOI: 10.1093/infdis/jiaf38210 / 2025
Relationship Among Village Doctor Training Level, Proximity to a Main Road, and Availability to Administer Intravenous Fluids for Diarrheal Illness.
Open forum infectious diseases
Amin MA and Khan II and Khan ZH and Hanson OR and Islam MT and Biswas D and Firoj MG and Nelson EJ and Qadri F and Watt MH and Leung DT and Ahmed SM and Khan AI
DOI: 10.1093/ofid/ofaf235 PubMed: 4033772104 / 2025
Physicians' Perspectives Regarding Informal Health Practitioners in Bangladesh.
The American journal of tropical medicine and hygiene
Khan ZH and Hanson OR and Amin MA and Khan II and Biswas D and Islam MT and Nelson EJ and Mangadu A and Qadri F and Watt MH and Leung DT and Khan AI
DOI: 10.4269/ajtmh.24-0597 PubMed: 4006821803 / 2025
Derivation and Internal Validation of a Clinical Prediction Model for Diagnosis of Spotted Fever Group Rickettsioses in Northern Tanzania
Open Forum Infectious Diseases
Robert J Williams and Ben J Brintz and William L Nicholson and John A Crump and Ganga Moorthy and Venace P Maro and Grace D Kinabo and James Ngocho and Wilbrod Saganda and Daniel T Leung and Matthew P Rubach
DOI: 10.1093/ofid/ofaf10002 / 2025
Longterm kinetics of vibriocidal antibody responses afterV. choleraeinfection in the Democratic Republic of Congo
Kilee L. Davis and Carmen Nieznanski and Felicien Maisha and Ben J. Brintz and Christy Clutter and Meer Alam and Cyrus Saleem and Afsar Ali and J. Glenn Morris and Daniel T. Leung
DOI: 10.1101/2025.02.26.2532296602 / 2025
Mucosal-associated invariant T (MAIT) cell responses in Salmonella enterica serovar Typhi strain Ty21a oral vaccine recipients.
Oxford Open Immunology
Shubhanshi Trivedi and Olivia J Cheng and Ben J Brintz and Richelle C Charles and Daniel T Leung
DOI: 10.1093/oxfimm/iqaf00202 / 2025
Automated post-run analysis of arrayed quantitative PCR amplification curves using machine learning.
Gates open research
Brintz BJ and Operario DJ and Brown DG and Wu S and Wang L and Houpt ER and Leung DT and Liu J and Platts-Mills JA
DOI: 10.12688/gatesopenres.16313.1 PubMed: 3985007201 / 2025
Dientamoeba fragilis cases identified by molecular detection, Utah, United States, 2014"2024
Epidemiology and Infection
Anna Jones and Marc Roger Couturier and Andrew T. Pavia and Daniel T. Leung
DOI: 10.1017/S0950268825000159Potential for an Electronic Clinical Decision Support Tool to Support Appropriate Antibiotic Use for Pediatric Diarrhea Among Village Doctors in Bangladesh.
Journal of the Pediatric Infectious Diseases Society
Khan II and Hanson OR and Khan ZH and Amin MA and Biswas D and Das JB and Munim MS and Shihab RM and Islam MT and Mangadu A and Nelson EJ and Ahmed SM and Qadri F and Watt MH and Leung DT and Khan AI
DOI: 10.1093/jpids/piae094 PubMed: 3942321211 / 2024
Etiologies of bloody diarrhea in children presenting with acute gastroenteritis to US emergency departments
Daniel T. Leung and Paola Fonseca-Romero and Ben Brintz and D. Matthew Vierkant and Jennifer Dien Bard and Daniel Cohen and Ara Festekjian and Amy Leber and Jami Jackson and Neena Kanwar and Chari Larsen and Rangaraj Selvarangan and Kimberle Chapin and Andrew Pavia and Sharia Ahmed
DOI: 10.1093/ofid/ofae69211 / 2024
Etiology of Severely Dehydrating Diarrheal Illness in Infants and Young Children Residing in Low- and Middle-Income Countries.
Open forum infectious diseases
Jones A and Ahmed SM and Platts-Mills JA and Kotloff KL and Levine AC and Nelson EJ and Pavia AT and Khan AI and Leung DT
DOI: 10.1093/ofid/ofae619 PubMed: 3949444910 / 2024
Challenges and Approaches to Establishing Multi-Pathogen Serosurveillance: Findings from the 2023 Serosurveillance Summit.
The American journal of tropical medicine and hygiene
Carcelen AC and Kong AC and Takahashi S and Hegde S and Jaenisch T and Chu M and Rochford R and Kostandova N and Gurley ES and Wesolowski A and Azman AS and van der Klis FRM and Moss WJ
DOI: 10.4269/ajtmh.24-0296 PubMed: 3922690609 / 2024
Mucosal-associated invariant T cells modulate innate immune cells and inhibit colon cancer growth
Scandinavian Journal of Immunology
Olivia J. Cheng and Eric J. Lebish and Owen Jensen and Damian Jacenik and Shubhanshi Trivedi and Jackson G. Cacioppo and Jeffrey Aub and Ellen J. Beswick and Daniel T. Leung
DOI: 10.1111/sji.1339109 / 2024
Identification, mapping, and self-reported practice patterns of village doctors in Sitakunda subdistrict, Bangladesh.
Journal of global health
Hanson OR and Khan II and Khan ZH and Amin MA and Biswas D and Islam MT and Nelson EJ and Ahmed SM and Brintz BJ and Hegde ST and Qadri F and Watt MH and Leung DT and Khan AI
DOI: 10.7189/jogh.14.04185 PubMed: 3926866709 / 2024
Randomized double-blind placebo-controlled study to evaluate the effect of long-acting mesalamine on postinfectious irritable bowel syndrome with diarrhea.
Neurogastroenterology and motility
Tuteja AK and Leung DT and Fang JC and Talley NJ and Stoddard GJ
DOI: 10.1111/nmo.14889 PubMed: 3910406108 / 2024
Development of a Shigella conjugate vaccine targeting Shigella flexneri 6 that is immunogenic and provides protection against virulent challenge.
Vaccine
Kelly M and Janardhanan J and Wagh C and Verma S and Charles RC and Leung DT and Kamruzzaman M and Pansuriya RK and Chowdhury F and Vann WF and Kaminski RW and Khan AI and Bhuiyan TR and Ryan ET
DOI: 10.1016/j.vaccine.2024.126263 PubMed: 3921777508 / 2024
Integrated Clinical, Climate, and Environmental Prediction Modeling for Diagnosis of Spotted Fever Group Rickettsioses in northern Tanzania
Robert J. Williams and Ben J. Brintz and William L. Nicholson and John A. Crump and Ganga Moorthy and Venace P. Maro and Grace D. Kinabo and James Ngocho and Wilbrod Saganda and Daniel T. Leung and Matthew P. Rubach
DOI: 10.1101/2024.06.20.2430925706 / 2024
Intestinal protozoa in returning travellers: a GeoSentinel analysis from 2007 to 2019
Journal of Travel Medicine
Thomas Weitzel and Ashley Brown and Michael Libman and Cecilia Perret and Ralph Huits and Lin Chen and Daniel T Leung and Karin Leder and Bradley A Connor and Marta D Menndez and Hilmir Asgeirsson and Eli Schwartz and Fernando Salvador and Denis Malvy and Mauro Saio and Francesca F Norman and Bhawana Amatya and Alexandre Duvignaud and Stephen Vaughan and Marielle Glynn and Carsten Schade Larsen and Christian Wejse and Martin P Grobusch and Abraham Goorhuis and Emmanuel Bottieau and Marc Shaw and Annemarie Hern and Watcharapong Piyaphanee and Wasin Matsee and Jose Muoz and Israel Molina and Frank Mockenhaupt and Francesco Castelli and Alberto Matteelli and Christina Coyle and Paul Kelly and Cosmina Zeana and Simin Aysel Florescu and Corneliu Petru Popescu and Stephen Vaughan and Susan Kuhn and Susan Anderson and Kunjana Mavunda and Carmelo Licitra and Francois Chappuis and Gilles Eperon and Jesse Waggoner and Henry Wu and Sabine Jordan and Johnnie Yates and Phi Truong Hoang Phu and Pr
DOI: 10.1093/jtm/taae01006 / 2024
Iron Is Critical for Mucosal-Associated Invariant T Cell Metabolism and Effector Functions.
Journal of immunology (Baltimore, Md. : 1950)
Ryan EK and Clutter C and De Barra C and Jenkins BJ and O'Shaughnessy S and Ryan OK and McKenna C and Heneghan HM and Walsh F and Finlay DK and Sinclair LV and Jones N and Leung DT and Hogan AE
DOI: 10.4049/jimmunol.2300649 PubMed: 3861928606 / 2024
Drivers of inappropriate use of antimicrobials in South Asia: A systematic review of qualitative literature
PLOS Global Public Health
Jennifer L. Murray and Ferdinand Mukumbang and Daniel T. Leung and Olivia R. Hanson and Sharia M. Ahmed and Andrew T. Pavia and Ashraful I. Khan and Julia E. Szymczak and Valerie M. Vaughn and Payal K. Patel and Debashish Biswas and Melissa H. Watt
DOI: 10.1371/journal.pgph.000250704 / 2024
Integration of population-level data sources into an individual-level clinical prediction model for dengue virus test positivity.
Science advances
Williams RJ and Brintz BJ and Ribeiro Dos Santos G and Huang AT and Buddhari D and Kaewhiran S and Iamsirithaworn S and Rothman AL and Thomas S and Farmer A and Fernandez S and Leung DT
DOI: 10.1126/sciadv.adj9786 PubMed: 3836384202 / 2024
Effectiveness of one dose of killed oral cholera vaccine in an endemic community in the Democratic Republic of the Congo: a matched case-control study.
The Lancet. Infectious diseases
Malembaka EB and Bugeme PM and Hutchins C and Xu H and Hulse JD and Demby MN and Gallandat K and Saidi JM and Rumedeka BB and Itongwa M and Tshiwedi-Tsilabia E and Kitoga F and Azman AS
DOI: 10.1016/s1473-3099(23)00742-9 PubMed: 3824619101 / 2024
MAIT Cells Modulate Innate Immune Cells and Inhibit Colon Cancer Growth
Olivia J. Cheng and Eric J. Lebish and Owen Jensen and Damian Jacenik and Shubhanshi Trivedi and Jackson Cacioppo and Jeffrey Aub and Ellen J. Beswick and Daniel T. Leung
DOI: 10.1101/2024.01.16.57589401 / 2024
Assessment and comparison of model estimated and directly observed weather data for prediction of diarrhoea aetiology
Epidemiology and Infection
Ben J. Brintz and Josh M. Colston and Sharia M. Ahmed and Dennis L. Chao and Benjamin F. Zaitchik and Daniel T. Leung
DOI: 10.1017/S0950268824001183Qualitative Assessment of a Smartphone-Based Mobile Health Tool to Guide Diarrhea Management in Bangladesh.
The American journal of tropical medicine and hygiene
Biswas D and Asadullah A and Khan SH and Khan ZH and Islam MT and Khan AI and Qadri F and Nelson EJ and Watt MH and Leung DT
DOI: 10.4269/ajtmh.23-0444 PubMed: 3808105112 / 2023
Epidemiology of rotavirus in humans, animals, and the environment in Africa: a systematic review and meta-analysis.
Daniel T. Leung and Richard Njouom
DOI: 10.1093/infdis/jiad50011 / 2023
Clinical Impact of Multiplex Molecular Diagnostic Testing in Children with Acute Gastroenteritis Presenting to An Emergency Department: A Multicenter Prospective Study
Andrew T. Pavia and Rangaraj Selvarangan and Jennifer Dien Bard and Daniel T Leung
DOI: 10.1093/cid/ciad71011 / 2023
Assessment of Model Estimated and Directly Observed Weather Data for Etiological Prediction of Diarrhea
Ben J. Brintz and Josh M. Colston and Sharia M. Ahmed and Dennis L. Chao and Ben Zaitschik and Daniel T. Leung
DOI: 10.1101/2023.10.12.2329695910 / 2023
Genomic Characterization of 2 Cutibacterium acnes Isolates from a Surgical Site Infection Reveals Large Genomic Inversion
Pathogens and Immunity
D. Garrett Brown and Taylor A. Wahlig and Angela Ma and Laura K. Certain and Peter N. Chalmers and Mark A. Fisher and Daniel T Leung
DOI: 10.20411/pai.v8i1.60610 / 2023
Gut microbiome perturbation, antibiotic resistance, and Escherichia coli strain dynamics associated with international travel: a metagenomic analysis.
The Lancet. Microbe
Worby CJ and Sridhar S and Turbett SE and Becker MV and Kogut L and Sanchez V and Bronson RA and Rao SR and Oliver E and Walker AT and Walters MS and Kelly P and Leung DT and Knouse MC and LaRocque RC
DOI: 10.1016/s2666-5247(23)00147-7 PubMed: 3771636409 / 2023
Derivation and validation of a clinical prediction model for risk-stratification of children hospitalized with severe pneumonia in Bangladesh
PLOS Global Public Health
Gazi Md. Salahuddin Mamun and Sindhu Kulandaipalayam Natarajan and Michael Zou and Monira Sarmin and Ben J. Brintz and Abu Sayem Mirza Md. Hasibur Rahman and Irin Parvin and Mst Mahmuda Ackhter and Mohammod Jobayer Chisti and Daniel T. Leung and Lubaba Shahrin
DOI: 10.1371/journal.pgph.000221608 / 2023
Sex difference in the discordance between Abbott Architect and EuroImmun serological assays.
PeerJ
Hartsell JD and Leung DT and Zhang Y and Delgado JC and Alder SC and Samore MH
DOI: 10.7717/peerj.15247 PubMed: 3748396007 / 2023
Development of Shigella conjugate vaccines targeting Shigella flexneri 2a and S. flexneri 3a using a simple platform-approach conjugation by squaric acid chemistry
Vaccine
Meagan Kelly and Anjali Mandlik and Richelle C. Charles and Smriti Verma and Stephen B. Calderwood and Daniel T. Leung and Rajib Biswas and Kamrul Islam and Mohammad Kamruzzaman and Fahima Chowdhury and Farhana Khanam and Willie F. Vann and Ashraful Islam Khan and Taufiqur Rahman Bhuiyan and Firdausi Qadri and Anthony R. Vortherms and Robert Kaminski and Pavol Kovc and Peng Xu and Edward T. Ryan
DOI: 10.1016/j.vaccine.2023.06.05207 / 2023
Population-Based Serologic Survey of Vibrio cholerae Antibody Titers before Cholera Outbreak, Haiti, 2022.
Emerging infectious diseases
Clutter CH and Klarman MB and Cajusma Y and Cato ET and Abu Sayeed M and Brinkley L and Jensen O and Baril C and De Rochars VMB and Azman AS and Long MT and Cummings D and Leung DT and Nelson EJ
DOI: 10.3201/eid2909.230174 PubMed: 3748716807 / 2023
Travel-Related Diagnoses Among U.S. Nonmigrant Travelers or Migrants Presenting to U.S. GeoSentinel Sites - GeoSentinel Network, 2012-2021.
Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002)
Brown AB and Miller C and Hamer DH and Kozarsky P and Libman M and Huits R and Rizwan A and Emetulu H and Waggoner J and Chen LH and Leung DT and Bourque D and Connor BA and Licitra C and Angelo KM
DOI: 10.15585/mmwr.ss7207a1 PubMed: 3736882006 / 2023
Derivation and external validation of a clinical prognostic model identifying children at risk of death following presentation for diarrheal care.
PLOS global public health
Ahmed SM and Brintz BJ and Talbert A and Ngari M and Pavlinac PB and Platts-Mills JA and Levine AC and Nelson EJ and Walson JL and Kotloff KL and Berkley JA and Leung DT
DOI: 10.1371/journal.pgph.0001937 PubMed: 3736886706 / 2023
Derivation and External Validation of a Clinical Prediction Model for Viral Diarrhea Etiology in Bangladesh.
Open forum infectious diseases
Garbern SC and Islam MT and Islam K and Ahmed SM and Brintz BJ and Khan AI and Taniuchi M and Platts-Mills JA and Qadri F and Leung DT
DOI: 10.1093/ofid/ofad295 PubMed: 3740495405 / 2023
Syndromic Panel Testing Among Patients With Infectious Diarrhea: The Challenge of Interpreting Clostridioides difficile Positivity on a Multiplex Molecular Panel.
Open forum infectious diseases
Pender M and Throneberry SK and Grisel N and Leung DT and Lopansri BK
DOI: 10.1093/ofid/ofad184 PubMed: 3771128004 / 2023
Clinical Prediction Rule to Guide Diagnostic Testing for Shigellosis and Improve Antibiotic Stewardship for Pediatric Diarrhea.
Open forum infectious diseases
Ahmed SM and Brintz BJ and Pavlinac PB and Hossain MI and Khan AI and Platts-Mills JA and Kotloff KL and Leung DT
DOI: 10.1093/ofid/ofad119 PubMed: 3699862903 / 2023
Development of a Prediction Model for the Acquisition of Extended Spectrum Beta-Lactam Resistant Organisms in U.S. International Travelers
D. Brown and Melissa Pender and Sushmita Sridhar and Jason Harris and Ben Brintz and Colin Worby and Sowmya Rao and Daniel Leung and Regina LaRocque and Sarah Turbett and Elizabeth Oliver and Edward Ryan and Ashlee Earl
DOI: 10.1093/jtm/taad02802 / 2023
Enhancing Mucosal-Associated Invariant T Cell Function and Expansion with Human Selective Serum
ImmunoHorizons
Daniel Labuz and Jackson Cacioppo and Kelin Li and Jeffrey Aub and Daniel T Leung
DOI: 10.4049/immunohorizons.220008201 / 2023
Derivation and external validation of clinical prediction rules identifying children at risk of linear growth faltering
eLife
Sharia M Ahmed and Ben J Brintz and Patricia B Pavlinac and Lubaba Shahrin and Sayeeda Huq and Adam C Levine and Eric J Nelson and James A Platts-Mills and Karen L Kotloff and Daniel T Leung
DOI: 10.7554/eLife.7849101 / 2023
Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance.
Biology of sex differences
Warren KJ and Deering-Rice C and Huecksteadt T and Trivedi S and Venosa A and Reilly C and Sanders K and Clayton F and Wyatt TA and Poole JA and Heller NM and Leung D and Paine R
DOI: 10.1186/s13293-022-00483-7 PubMed: 3660935801 / 2023
Clinical prediction rule to guide diagnostic testing forShigellosisand improve antibiotic stewardship for pediatric diarrhea
Sharia M. Ahmed and Ben J. Brintz and Patricia B. Pavlinac and Md Iqbal Hossain and Ashraful Islam Khan and James A. Platts-Mills and Karen L. Kotloff and Daniel T. Leung
DOI: 10.1101/2022.12.19.2228370112 / 2022
Combining antibody markers for serosurveillance of SARS-CoV-2 to estimate seroprevalence and time-since-infection - CORRIGENDUM.
Epidemiology and infection
Bhuiyan MS and Brintz BJ and Whitcombe AL and Markmann AJ and Bartelt LA and Moreland NJ and Azman AS and Leung DT
DOI: 10.1017/s0950268822001017 PubMed: 3642660311 / 2022
Building an integrated serosurveillance platform to inform public health interventions: Insights from an experts' meeting on serum biomarkers.
PLoS neglected tropical diseases
Wiens KE and Jauregui B and Arnold BF and Banke K and Wade D and Hayford K and Costero-Saint Denis A and Hall RH and Salje H and Rodriguez-Barraquer I and Azman AS and Vernet G and Collaboration on Integrated Biomarkers Surveillance
DOI: 10.1371/journal.pntd.0010657 PubMed: 3620142810 / 2022
Identifying Recent Cholera Infections Using a Multiplex Bead Serological Assay.
mBio
Jones FK and Bhuiyan TR and Muise RE and Khan AI and Slater DM and Hutt Vater KR and Chowdhury F and Kelly M and Xu P and Kovc P and Biswas R and Kamruzzaman M and Ryan ET and Azman AS
DOI: 10.1128/mbio.01900-22 PubMed: 3628652010 / 2022
Enhancing Mucosal-Associated Invariant T (MAIT) cell function and expansion with human selective serum
Daniel Labuz and Jackson Cacioppo and Kelin Li and Jeffrey Aub and Daniel T. Leung
DOI: 10.1101/2022.10.10.51136810 / 2022
Mucosal-associated invariant T (MAIT) cell responses in Salmonella enterica serovar Typhi strain Ty21a oral vaccine recipients
Shubhanshi Trivedi and Olivia Cheng and Ben J Brintz and Richelle C. Charles and Daniel T Leung
DOI: 10.1101/2022.10.04.2228065110 / 2022
Improving Antibiotic Stewardship for Diarrheal Disease With Probability-Based Electronic Clinical Decision Support: A Randomized Crossover Trial.
JAMA pediatrics
Nelson EJ and Khan AI and Keita AM and Brintz BJ and Keita Y and Sanogo D and Islam MT and Khan ZH and Rashid MM and Nasrin D and Watt MH and Ahmed SM and Haaland B and Pavia AT and Leung DT
DOI: 10.1001/jamapediatrics.2022.2535 PubMed: 3603692010 / 2022
Targeted multi-omic analysis of human skin tissue identifies alterations of conventional and unconventional T cells associated with burn injury
Daniel Labuz and Giavonni Lewis and Irma D. Fleming and Callie M. Thompson and Yan Zhai and Matthew A. Firpo and Daniel T. Leung
DOI: 10.1101/2022.08.30.50580009 / 2022
Erratum to: Use of a MAIT Activating Ligand, 5-OP-RU, as a Mucosal Adjuvant in a Murine Model of Vibrio cholerae O1 Vaccination
Pathogens and Immunity
Owen Jensen and Shubhanshi Trivedi and Jackson G. Cacioppo and Kelin Li and Jeffrey Aub and J. Scott Hale and Edward T. Ryan and Daniel T Leung
DOI: 10.20411/pai.v7i1.54109 / 2022
Incidence Rate and Risk Factors Associated with Travelers' Diarrhea in International Travelers Departing from Utah, USA.
The American journal of tropical medicine and hygiene
Fernandez V and Ahmed SM and Graves MC and Pender MA and Shoemaker H and Birich H and Pupaibool J and Benson LS and Leung DT
DOI: 10.4269/ajtmh.21-1005 PubMed: 3597028608 / 2022
Introduction of an Electronic Clinical Decision Support Tool to Inform Prescribing for Pediatric Diarrhea in Bangladesh and Mali: Do Provider Expectations Predict Experiences?
The American journal of tropical medicine and hygiene
Keita AM and Brintz BJ and Khan AI and Taufiqul Islam M and Khan ZH and Keita Y and Hwang J and Nelson EJ and Qadri F and Sow S and Leung DT and Watt MH
DOI: 10.4269/ajtmh.21-1248 PubMed: 3589536507 / 2022
Use of a MAIT activating ligand, 5-OP-RU, as a mucosal adjuvant in a murine model of Vibrio cholerae O1 vaccination
Owen Jensen and Shubhanshi Trivedi and Kelin Li and Jeffrey Aub and J. Scott Hale and Edward T. Ryan and Daniel T. Leung
DOI: 10.1101/2022.06.17.49660306 / 2022
Mucosal-Associated Invariant T (MAIT) cells are highly activated in duodenal tissue of humans with Vibrio cholerae O1 infection: A preliminary report.
PLoS neglected tropical diseases
Bhuiyan TR and Rahman MA and Trivedi S and Afroz T and Al Banna H and Hoq MR and Pop I and Jensen O and Rashu R and Uddin MI and Hossain M and Khan AI and Chowdhury F and Harris JB and Leung DT
DOI: 10.1371/journal.pntd.0010411 PubMed: 3555152205 / 2022
Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association's Get With The Guidelines Registry.
Journal of racial and ethnic health disparities
Shah KS and Reyes-Miranda AE and Bradley SM and Breathett K and Das SR and Gluckman TJ and Gupta D and Leung DT and Mutharasan RK and Peterson PN and Spivak ES and Shah RU
DOI: 10.1007/s40615-022-01277-8 PubMed: 3538037104 / 2022
Global landscape of SARS-CoV-2 genomic surveillance and data sharing.
Nature genetics
Chen Z and Azman AS and Chen X and Zou J and Tian Y and Sun R and Xu X and Wu Y and Lu W and Ge S and Zhao Z and Yang J and Leung DT and Domman DB and Yu H
DOI: 10.1038/s41588-022-01033-y PubMed: 3534730503 / 2022
Derivation and external validation of clinical prediction rules identifying children at risk of linear growth faltering (stunting) presenting for diarrheal care
Sharia M. Ahmed and Ben J. Brintz and Patricia B Pavlinac and Lubaba Shahrin and Sayeeda Huq and Adam C. Levine and Eric J. Nelson and James A Platts-Mills and Karen L Kotloff and Daniel T Leung
DOI: 10.1101/2022.03.08.2227179603 / 2022
Water, Sanitation, and Hygiene and Nutritional Risk Factors for Acute Respiratory Illness in the Democratic Republic of the Congo: REDUCE Prospective Cohort Study.
The American journal of tropical medicine and hygiene
Endres K and Sanvura P and Williams C and Thomas ED and Kuhl J and Coglianese N and Bauler S and Franois R and Bisimwa JC and Mirindi P and Perin J and Namegabe A and Bisimwa L and Leung D and George CM
DOI: 10.4269/ajtmh.21-0676 PubMed: 3531328103 / 2022
External validation of a mobile clinical decision support system for diarrhea etiology prediction in children: A multicenter study in Bangladesh and Mali.
eLife
Garbern SC and Nelson EJ and Nasrin S and Keita AM and Brintz BJ and Gainey M and Badji H and Nasrin D and Howard J and Taniuchi M and Platts-Mills JA and Kotloff KL and Haque R and Leung DT
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Michal Stevens, A. and Esposito, D.H. and Stoney, R.J. and Hamer, D.H. and Flores-Figueroa, J. and Bottieau, E. and Connor, B.A. and Gkrania-Klotsas, E. and Goorhuis, A. and Hynes, N.A. and Libman, M. and Lopez-Velez, R. and McCarthy, A.E. and von Sonnenburg, F. and Schwartz, E. and van Genderen, P.J.J. and Scott Benson, L. and Leung, D.T. and Kain, K. and Caumes, E. and ?sgeirsson, H. and Rothe, C. and Stauffer, W. and Schlagenhauf, P. and Kozarsky, P. and Haulman, J. and Licitra, C. and Yoshimura, Y. and Chappuis, F. and Mockenhaupt, F. and Borwein, S. and Jensenius, M. and Anderson, S. and Castelli, F. and Chen, L. and Leder, K. and Vincelette, J. and Shaw, M. and Coyle, C. and Kelly, P. and Cahill, J. and Lim, P.-L. and Kanagawa, S. and Hajek, J.
DOI: 10.1093/jtm/taw099Human mucosal-associated invariant T (MAIT) cells possess capacity for B cell help
Journal of Leukocyte Biology
Bennett, M.S. and Trivedi, S. and Iyer, A.S. and Hale, J.S. and Leung, D.T.
DOI: 10.1189/jlb.4A0317-116RMalaria after international travel: A GeoSentinel analysis, 2003-2016
Malaria Journal
Angelo, K.M. and Libman, M. and Caumes, E. and Hamer, D.H. and Kain, K.C. and Leder, K. and Grobusch, M.P. and Hagmann, S.H. and Kozarsky, P. and Lalloo, D.G. and Lim, P.-L. and Patimeteeporn, C. and Gautret, P. and Odolini, S. and Chappuis, F. and Esposito, D.H. and Javelle, E. and Castelli, F. and Matteelli, A. and Perignon, A. and Rothe, C. and Rapp, C. and Ficko, C. and Schwartz, E. and Von Sonnenburg, F. and Piyaphanee, W. and Silachamroon, U. and Boggild, A. and Van Genderen, P. and Torresi, J. and Jensenius, M. and Kanagawa, S. and Kato, Y. and Yansouni, C. and McCarthy, A. and Kelly, P. and Goorhuis, B. and L{\'o}pez-V{\'e}lez, R. and Norman, F. and Mendelson, M. and Vincent, P. and Gkrania-Klotsas, E. and Warne, B. and Malvy, D. and Duvignaud, A. and Bottieau, E. and Clerinx, J. and Coyle, C. and ?sgeirsson, H. and Glans, H. and Schlagenhauf, P. and Weber, R. and Mockenhaupt, F. and Harms-Zwingenberger, G. and Beeching, N. and Hajek, J. and Ghesquiere, W. and Wu, H. and Barnett, E. and Hockberg, N. and Yoshimura, Y. and Tachikawa, N. and Cahill, J. and McKinley, G. and Stauffer, W. and Walker, P. and Kuhn, S. and Chen, L. and Leung, D. and Benson, S. and Larsen, C.S. and Wejse, C. and Field, V. and Licitra, C. and Klochko, A. and Hynes, N. and Perez, C.P. and Connor, B. and Murphy, H. and Pandey, P. and Vincelette, J. and Barkati, S. and Florescu, S.A. and Popescu, C.P. and Blumberg, L. and De Frey, A. and Anderson, S. and Shaw, M. and Hern, A. and Molina, I. and Yates, J. and Siu, H. and Valdez, L.M. and Haulman, J. and Roesel, D. and Phu, P.T.H. and Borwein, S.
DOI: 10.1186/s12936-017-1936-3High hepatitis e seroprevalence among displaced persons in South Sudan
American Journal of Tropical Medicine and Hygiene
Azman, A.S. and Bouhenia, M. and Iyer, A.S. and Rumunu, J. and Laku, R.L. and Wamala, J.F. and Rodriguez-Barraquer, I. and Lessler, J. and Gignoux, E. and Luquero, F.J. and Leung, D.T. and Gurley, E.S. and Ciglenecki, I.
DOI: 10.4269/ajtmh.16-0620Clinical characteristics of laboratory-confirmed leptospirosis in Okinawa, Japan, 1974-2015: High incidence of Jarisch-Herxheimer reaction
Transactions of the Royal Society of Tropical Medicine and Hygiene
Tsuha, S. and Taniguchi, T. and Shiiki, S. and Narita, M. and Leung, D.T.
DOI: 10.1093/trstmh/trw061Traveler's Diarrhea
Medical Clinics of North America
Giddings, S.L. and Stevens, A.M. and Leung, D.T.
DOI: 10.1016/j.mcna.2015.08.017Immune Responses to an Oral Cholera Vaccine in Internally Displaced Persons in South Sudan
Scientific Reports
Iyer, A.S. and Bouhenia, M. and Rumunu, J. and Abubakar, A. and Gruninger, R.J. and Pita, J. and Lino, R.L. and Deng, L.L. and Wamala, J.F. and Ryan, E.T. and Martin, S. and Legros, D. and Lessler, J. and Sack, D.A. and Luquero, F.J. and Leung, D.T. and Azman, A.S.
DOI: 10.1038/srep35742O-Specific polysaccharide-specific memory b cell responses in young children, older children, and adults infected with vibrio cholerae o1 ogawa in Bangladesh
Clinical and Vaccine Immunology
Aktar, A. and Rahman, M.A. and Afrin, S. and Faruk, M.O. and Uddin, T. and Akter, A. and Sami, M.I.N. and Yasmin, T. and Chowdhury, F. and Khan, A.I. and Leung, D.T. and LaRocque, R.C. and Charles, R.C. and Bhuiyan, T.R. and Mandlik, A. and Kelly, M. and Kov{\'a}?, P. and Xu, P. and Calderwood, S.B. and Harris, J.B. and Qadri, F. and Ryan, E.T.
DOI: 10.1128/CVI.00647-15Biomarkers of Environmental Enteropathy are Positively Associated with Immune Responses to an Oral Cholera Vaccine in Bangladeshi Children
PLoS Neglected Tropical Diseases
Uddin, M.I. and Islam, S. and Nishat, N.S. and Hossain, M. and Rafique, T.A. and Rashu, R. and Hoq, M.R. and Zhang, Y. and Saha, A. and Harris, J.B. and Calderwood, S.B. and Bhuiyan, T.R. and Ryan, E.T. and Leung, D.T. and Qadri, F.
DOI: 10.1371/journal.pntd.0005039Prevention and Control of Childhood Pneumonia and Diarrhea
Pediatric Clinics of North America
Leung, D.T. and Chisti, M.J. and Pavia, A.T.
DOI: 10.1016/j.pcl.2015.08.003Innate-like lymphocytes in intestinal infections
Current Opinion in Infectious Diseases
Bennett, M.S. and Round, J.L. and Leung, D.T.
DOI: 10.1097/QCO.0000000000000189Plasma leptin levels in children hospitalized with cholera in Bangladesh
American Journal of Tropical Medicine and Hygiene
Falkard, B. and Uddin, T. and Rahman, M.A. and Franke, M.F. and Aktar, A. and Uddin, M.I. and Bhuiyan, T.R. and Leung, D.T. and Charles, R.C. and LaRocque, R.C. and Harris, J.B. and Calderwood, S.B. and Qadri, F. and Ryan, E.T.
DOI: 10.4269/ajtmh.15-0172Profile of an HIV testing and counseling unit in Bangladesh: Majority of new diagnoses among returning migrant workers and spouses
PLoS ONE
Urmi, A.Z. and Leung, D.T. and Wilkinson, V. and Miah, M.A.A. and Rahman, M. and Azim, T.
DOI: 10.1371/journal.pone.0141483Cholera in pregnancy: Clinical and immunological aspects
International Journal of Infectious Diseases
Khan, A.I. and Chowdhury, F. and Leung, D.T. and Larocque, R.C. and Harris, J.B. and Ryan, E.T. and Calderwood, S.B. and Qadri, F.
DOI: 10.1016/j.ijid.2015.08.006Concurrent pneumonia in children under 5 years of age presenting to a diarrheal hospital in Dhaka, Bangladesh
American Journal of Tropical Medicine and Hygiene
Leung, D.T. and Das, S.K. and Malek, M.A. and Faruque, A.S.G. and Qadri, F. and Chisti, M.J. and Ryan, E.T.
DOI: 10.4269/ajtmh.15-0074Factors Associated with Non-typhoidal Salmonella Bacteremia versus Typhoidal Salmonella Bacteremia in Patients Presenting for Care in an Urban Diarrheal Disease Hospital in Bangladesh
PLoS Neglected Tropical Diseases
Shahunja, K.M. and Leung, D.T. and Ahmed, T. and Bardhan, P.K. and Ahmed, D. and Qadri, F. and Ryan, E.T. and Chisti, M.J.
DOI: 10.1371/journal.pntd.0004066A cholera conjugate vaccine containing ospecific polysaccharide (OSP) of V. cholera o1 inaba and recombinant fragment of tetanus toxin heavy chain (OSP:rTTHC) induces serum, memory and lamina proprial responses against OSP and is protective in mice
PLoS Neglected Tropical Diseases
Sayeed, M.A. and Bufano, M.K. and Xu, P. and Eckhoff, G. and Charles, R.C. and Alam, M.M. and Sultana, T. and Rashu, M.R. and Berger, A. and Escobedo, G.G. and Mandlik, A. and Bhuiyan, T.R. and Leung, D.T. and LaRocque, R.C. and Harris, J.B. and Calderwood, S.B. and Qadri, F. and Vann, W.F. and Kov{\'a}?, P. and Ryan, E.T.
DOI: 10.1371/journal.pntd.0003881Characteristics and predictors of death among hospitalized HIV-infected patients in a low HIV prevalence country: Bangladesh
PLoS ONE
Shahrin, L. and Leung, D.T. and Matin, N. and Pervez, M.M. and Azim, T. and Bardhan, P.K. and Heffelfinger, J.D. and Chisti, M.J.
DOI: 10.1371/journal.pone.0113095Impact of Ramadan on clinical and microbiologic parameters of patients seen at a diarrheal hospital in Urban Dhaka, Bangladesh, 1996-2012
American Journal of Tropical Medicine and Hygiene
Leung, D.T. and Das, S.K. and Malek, M.A. and Qadri, F. and Faruque, A.S.G. and Ryan, E.T.
DOI: 10.4269/ajtmh.13-0513Clinical profile of hospitalized HIV-infected children in Bangladesh, a low-HIV-prevalence country
Paediatrics and International Child Health
Shahrin, L. and Leung, D.T. and Matin, N. and Kawser, C.A. and Pervez, M.M. and Chisti, M.J.
DOI: 10.1179/2046905513Y.0000000100Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera
American Journal of Tropical Medicine and Hygiene
Uddin, T. and Aktar, A. and Xu, P. and Johnson, R.A. and Rahman, M.A. and Leung, D.T. and Afrin, S. and Akter, A. and Alam, M.M. and Rahman, A. and Chowdhury, F. and Khan, A.I. and Bhuiyan, T.R. and Bufano, M.K. and Rashu, R. and Yu, Y. and Wu-Freeman, Y. and Harris, J.B. and LaRocque, R.C. and Charles, R.C. and Kova??, P. and Calderwood, S.B. and Ryan, E.T. and Qadri, F.
DOI: 10.4269/ajtmh.13-0498Circulating Mucosal Associated Invariant T Cells Are Activated in Vibrio cholerae O1 Infection and Associated with Lipopolysaccharide Antibody Responses
PLoS Neglected Tropical Diseases
Leung, D.T. and Bhuiyan, T.R. and Nishat, N.S. and Hoq, M.R. and Aktar, A. and Rahman, M.A. and Uddin, T. and Khan, A.I. and Chowdhury, F. and Charles, R.C. and Harris, J.B. and Calderwood, S.B. and Qadri, F. and Ryan, E.T.
DOI: 10.1371/journal.pntd.0003076Bacterial shedding in household contacts of cholera patients in Dhaka, Bangladesh
American Journal of Tropical Medicine and Hygiene
Weil, A.A. and Begum, Y. and Chowdhury, F. and Khan, A.I. and Leung, D.T. and LaRocque, R.C. and Charles, R.C. and Ryan, E.T. and Calderwood, S.B. and Qadri, F. and Harris, J.B.
DOI: 10.4269/ajtmh.14-0095Cellular and cytokine responses to Salmonella enterica serotype typhi proteins in patients with typhoid fever in Bangladesh
American Journal of Tropical Medicine and Hygiene
Bhuiyan, M.S. and Sayeed, M.A. and Khanam, F. and Leung, D.T. and Bhuiyan, T.R. and Sheikh, A. and Salma, U. and LaRocque, R.C. and Harris, J.B. and Pacek, M. and Calderwood, S.B. and LaBaer, J. and Ryan, E.T. and Qadri, F. and Charles, R.C.
DOI: 10.4269/ajtmh.13-0261Immunoproteomic analysis of antibody in lymphocyte supernatant in patients with typhoid fever in Bangladesh
Clinical and Vaccine Immunology
Charles, R.C. and Liang, L. and Khanam, F. and Sayeed, M.A. and Hung, C. and Leung, D.T. and Baker, S. and Ludwig, A. and Harris, J.B. and LaRocque, R.C. and Calderwood, S.B. and Qadri, F. and Felgner, P.L. and Ryan, E.T.
DOI: 10.1128/CVI.00661-13Evaluation in Mice of a Conjugate Vaccine for Cholera Made from Vibrio cholerae O1 (Ogawa) O-Specific Polysaccharide
PLoS Neglected Tropical Diseases
Alam, M.M. and Bufano, M.K. and Xu, P. and Kalsy, A. and Yu, Y. and Freeman, Y.W. and Sultana, T. and Rashu, M.R. and Desai, I. and Eckhoff, G. and Leung, D.T. and Charles, R.C. and LaRocque, R.C. and Harris, J.B. and Clements, J.D. and Calderwood, S.B. and Qadri, F. and Vann, W.F. and Kov{\'a}?, P. and Ryan, E.T.
DOI: 10.1371/journal.pntd.0002683Changing Emergence of Shigella Sero-Groups in Bangladesh: Observation from Four Different Diarrheal Disease Hospitals
PLoS ONE
Das, S.K. and Ahmed, S. and Ferdous, F. and Farzana, F.D. and Chisti, M.J. and Leung, D.T. and Malek, M.A. and Talukder, K.A. and Bardhan, P.K. and Salam, M.A. and Faruque, A.S.G. and Raqib, R.
DOI: 10.1371/journal.pone.0062029Non-typhoidal Salmonella gastroenteritis at a diarrheal hospital in Dhaka, Bangladesh, 1996-2011
American Journal of Tropical Medicine and Hygiene
Leung, D.T. and Das, S.K. and Malek, M.A. and Ahmed, D. and Khanam, F. and Qadri, F. and Faruque, A.S.G. and Ryan, E.T.
DOI: 10.4269/ajtmh.12-0672Identification of in vivo-induced bacterial proteins during human infection with Salmonella enterica serotype paratyphi a
Clinical and Vaccine Immunology
Alam, M.M. and Tsai, L.L. and Rollins, S.M. and Sheikh, A. and Khanam, F. and Bufano, M.K. and Yu, Y. and Wu-Freeman, Y. and Kalsy, A. and Sultana, T. and Abu Sayeed, M. and Jahan, N. and LaRocque, R.C. and Harris, J.B. and Leung, D.T. and Abdullah Brooks, W. and Calderwood, S.B. and Charles, R.C. and Qadri, F. and Ryan, E.T.
DOI: 10.1128/CVI.00054-13Identification of Immunogenic Salmonella enterica Serotype Typhi Antigens Expressed in Chronic Biliary Carriers of S. Typhi in Kathmandu, Nepal
PLoS Neglected Tropical Diseases
Charles, R.C. and Sultana, T. and Alam, M.M. and Yu, Y. and Wu-Freeman, Y. and Bufano, M.K. and Rollins, S.M. and Tsai, L. and Harris, J.B. and LaRocque, R.C. and Leung, D.T. and Brooks, W.A. and Nga, T.V.T. and Dongol, S. and Basnyat, B. and Calderwood, S.B. and Farrar, J. and Khanam, F. and Gunn, J.S. and Qadri, F. and Baker, S. and Ryan, E.T.
DOI: 10.1371/journal.pntd.0002335Antibody avidity in humoral immune responses in Bangladeshi children and adults following administration of an oral killed cholera vaccine
Clinical and Vaccine Immunology
Alam, M.M. and Leung, D.T. and Akhtar, M. and Nazim, M. and Akter, S. and Uddin, T. and Khanam, F. and Mahbuba, D.A. and Ahmad, S.M. and Bhuiyan, T.R. and Calderwood, S.B. and Ryan, E.T. and Qadri, F.
DOI: 10.1128/CVI.00341-13Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh
Clinical and Vaccine Immunology
Leung, D.T. and Uddin, T. and Xu, P. and Aktar, A. and Johnson, R.A. and Rahman, M.A. and Alam, M.M. and Bufano, M.K. and Eckhoff, G. and Wu-Freeman, Y. and Yu, Y. and Sultana, T. and Khanam, F. and Saha, A. and Chowdhury, F. and Khan, A.I. and Charles, R.C. and LaRocque, R.C. and Harris, J.B. and Calderwood, S.B. and Kov{\'a}?, P. and Qadri, F. and Ryan, E.T.
DOI: 10.1128/CVI.00035-13Factors associated with encephalopathy in patients with Salmonella enterica serotype typhi bacteremia presenting to a diarrheal hospital in Dhaka, Bangladesh
American Journal of Tropical Medicine and Hygiene
Leung, D.T. and Bogetz, J. and Itoh, M. and Ganapathi, L. and Pietroni, M.A.C. and Ryan, E.T. and Chisti, M.J.
DOI: 10.4269/ajtmh.2012.11-0750Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh (Clinical and Vaccine Immunology (2012) 19, 5, (690-698))
Clinical and Vaccine Immunology
Leung, D.T. and Rahman, M.A. and Mohasin, M. and Patel, S.M. and Aktar, A. and Khanam, F. and Uddin, T. and Riyadh, M.A. and Saha, A. and Alam, M.M. and Chowdhury, F. and Khan, A.I. and Charles, R. and LaRocque, R. and Harris, J.B. and Calderwood, S.B. and Qadri, F. and Ryan, E.T.
DOI: 10.1128/CVI.00299-12Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh
Clinical and Vaccine Immunology
Leung, D.T. and Rahman, M.A. and Mohasin, M. and Patel, S.M. and Aktar, A. and Khanam, F. and Uddin, T. and Riyadh, M.A. and Saha, A. and Alam, M.M. and Chowdhury, F. and Khan, A.I. and Charles, R. and LaRocque, R. and Harris, J.B. and Calderwood, S.B. and Qadri, F. and Ryan, E.T.
DOI: 10.1128/CVI.05615-11Immune responses to cholera in children
Expert Review of Anti-Infective Therapy
Leung, D.T. and Chowdhury, F. and Calderwood, S.B. and Qadri, F. and Ryan, E.T.
DOI: 10.1586/eri.12.23Frequency of reexposure to Vibrio cholerae O1 evaluated by subsequent vibriocidal titer rise after an episode of severe cholera in a highly endemic area in Bangladesh
American Journal of Tropical Medicine and Hygiene
Weil, A.A. and Chowdhury, F. and Khan, A.I. and Leung, D.T. and Uddin, T. and Begum, Y.A. and Saha, N.C. and Charles, R.C. and LaRocque, R.C. and Harris, J.B. and Ryan, E.T. and Qadri, F. and Calderwood, S.B.
DOI: 10.4269/ajtmh.2012.12-0323Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera
Clinical and Vaccine Immunology
Arifuzzaman, M. and Rashu, R. and Leung, D.T. and Hosen, M.I. and Bhuiyan, T.R. and Bhuiyan, M.S. and Rahman, M.A. and Khanam, F. and Saha, A. and Charles, R.C. and LaRocque, R.C. and Weil, A.A. and Clements, J.D. and Holmes, R.K. and Calderwood, S.B. and Harris, J.B. and Ryan, E.T. and Qadri, F.
DOI: 10.1128/CVI.00196-12Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera
Clinical and Vaccine Immunology
Johnson, R.A. and Uddin, T. and Aktar, A. and Mohasin, M. and Alam, M.M. and Chowdhury, F. and Harris, J.B. and LaRocque, R.C. and Bufano, M.K. and Yu, Y. and Wu-Freeman, Y. and Leung, D.T. and Sarracino, D. and Krastins, B. and Charles, R.C. and Xu, P. and Kov{\'a}?, P. and Calderwood, S.B. and Qadri, F. and Ryan, E.T.
DOI: 10.1128/CVI.00321-12Transcutaneous immunization with a Vibrio cholerae O1 Ogawa synthetic hexasaccharide conjugate following oral whole-cell cholera vaccination boosts vibriocidal responses and induces protective immunity in mice
Clinical and Vaccine Immunology
Tarique, A.A. and Kalsy, A. and Arifuzzaman, M. and Rollins, S.M. and Charles, R.C. and Leung, D.T. and Harris, J.B. and LaRocque, R.C. and Sheikh, A. and Bhuiyan, M.S. and Saksena, R. and Clements, J.D. and Calderwood, S.B. and Qadri, F. and Kov{\'a}?, P. and Ryan, E.T.
DOI: 10.1128/CVI.05689-11Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh
Clinical and Vaccine Immunology
Patel, S.M. and Rahman, M.A. and Mohasin, M. and Riyadh, M.A. and Leung, D.T. and Alam, M.M. and Chowdhury, F. and Khan, A.I. and Weil, A.A. and Aktar, A. and Nazim, M. and LaRocque, R.C. and Ryan, E.T. and Calderwood, S.B. and Qadri, F. and Harris, J.B.
DOI: 10.1128/CVI.00037-12Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh
Clinical and Vaccine Immunology
Leung, D.T. and Rahman, M.A. and Mohasin, M. and Riyadh, M.A. and Patel, S.M. and Alam, M.M. and Chowdhury, F. and Khan, A.I. and Kalivoda, E.J. and Aktar, A. and Bhuiyan, M.S. and LaRocque, R.C. and Harris, J.B. and Calderwood, S.B. and Qadri, F. and Ryan, E.T.
DOI: 10.1128/CVI.05124-11Interferon- and proliferation responses to Salmonella enterica serotype Typhi proteins in patients with S. Typhi bacteremia in Dhaka, Bangladesh
PLoS Neglected Tropical Diseases
Sheikh, A. and Khanam, F. and Sayeed, M.A. and Rahman, T. and Pacek, M. and Hu, Y. and Rollins, A. and Bhuiyan, M.S. and Rollins, S. and Kalsy, A. and Arifuzzaman, M. and Leung, D.T. and Sarracino, D.A. and Krastins, B. and Charles, R.C. and LaRocque, R.C. and Cravioto, A. and Calderwood, S.B. and Brooks, W.A. and Harris, J.B. and LaBaer, J. and Qadri, F. and Ryan, E.T.
DOI: 10.1371/journal.pntd.0001193In vivo expression of salmonella enterica serotype typhi genes in the blood of patients with typhoid fever in Bangladesh
PLoS Neglected Tropical Diseases
Sheikh, A. and Charles, R.C. and Sharmeen, N. and Rollins, S.M. and Harris, J.B. and Bhuiyan, M.S. and Arifuzzaman, M. and Khanam, F. and Bukka, A. and Kalsy, A. and Porwollik, S. and Leung, D.T. and Brooks, W.A. and LaRocque, R.C. and Hohmann, E.L. and Cravioto, A. and Logvinenko, T. and Calderwood, S.B. and McClelland, M. and Graham, J.E. and Qadri, F. and Ryan, E.T.
DOI: 10.1371/journal.pntd.0001419First report of prosthetic joint infection by Gemella sanguinis and associated "pseudosatelliting" phenomenon on culture
Journal of Clinical Microbiology
Leung, D.T. and Davis, E.M. and Qian, Q. and Gold, H.S.
DOI: 10.1128/JCM.01050-11Inadequacy of Plasma Acyclovir Levels at Delivery in Patients With Genital Herpes Receiving Oral Acyclovir Suppressive Therapy in Late Pregnancy
Journal of Obstetrics and Gynaecology Canada
Leung, D.T. and Henning, P.A. and Wagner, E.C. and Blasig, A. and Wald, A. and Sacks, S.L. and Corey, L. and Money, D.M.
DOI: 10.1016/S1701-2163(16)34374-2Pre-conceptional folic acid supplementation in uninsured pregnant Hispanic women [4]
Southern Medical Journal
Leung, D.T. and Ernest, J.M.
DOI: 10.1097/01.smj.0000252985.47774.89Docosanol: A topical antiviral for herpes labialis
Expert Opinion on Pharmacotherapy
Leung, D.T. and Sacks, S.L.
DOI: 10.1517/14656566.5.12.2567Current treatment options to prevent perinatal transmission of herpes simplex virus
Expert Opinion on Pharmacotherapy
Leung, D.T. and Sacks, S.L.
DOI: 10.1517/14656566.4.10.1809Development and validation of a plasma assay for acyclovir using high-performance capillary electrophoresis with sample stacking
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Vo, H.C. and Henning, P.A. and Leung, D.T. and Sacks, S.L.
DOI: 10.1016/S1570-0232(02)00116-2Evidence of dual sites of action of dendrimers: SPL-2999 inhibits both virus entry and late stages of herpes simplex virus replication
Antiviral Research
Gong, Y. and Matthews, B. and Cheung, D. and Tam, T. and Gadawski, I. and Leung, D. and Holan, G. and Raff, J. and Sacks, S.
DOI: 10.1016/S0166-3542(02)00054-2Current recommendations for the treatment of genital herpes
Drugs
Leung, D.T. and Sacks, S.L.
Artificial intelligence-enabled decision support for diarrheal illness
Building on our previous work using AI to help doctors decide whether to give antibiotics or not to a child with diarrhea, we are now working to use AI to improve healthcare worker- and caregiver-based assessment and management of dehydration due to diarrhea.
Harnessing MAIT cells for child health
Mucosal-associated invariant T (MAIT) cells are special white blood cells that are activated by microbial metabolites and have both innate and adaptive properties. We are using organoids and cutting-edge molecular biology methods to understand the regulation of these cells and how they can be harnessed to treat and prevent infections and cancer.
Immune responses to commensals in early life
Building on our knowledge of how the immune system develops and responds against pathogens, we are studying the development of immune responses against the microbiota, and the role they play in the health of children.
Grants
Principal Investigator. Development of clinical decision tools for management of diarrhea of children in high and low resource settings. Funding Source: US NIH
Principal Investigator. A mobile health tool to improve antibiotic stewardship among village doctors in Bangladesh. Funding Source: US NIH
Principal Investigator. MAIT cells as a therapeutic approach for gastrointestinal cancers. Funding Source: US NIH
Principal Investigator. Mentoring patient-oriented researchers in pediatric diarrhea. Funding Source: US NIH
Honours & Awards
2025 - Bailey K. Ashford Medal, American Society of Tropical Medicine & Hygiene
2025 - Outstanding Undergraduate Mentor Award, School of Medicine, University of Utah
2017 - Best Teaching Faculty, Division of Infectious Diseases, University of Utah
2017 - William D. Odell Young Investigator Award, Department of Internal Medicine, University of Utah
Our Research
At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.
EXPLORE OUR RESEARCH