Chronic kidney disease (CKD) is a significant and growing public health problem. It is currently estimated that 13% of the adult population has CKD and it confers a 5-fold increased risk of premature cardiovascular disease and death. Those who survive long enough eventually require renal replacement therapy with dialysis or a kidney transplant. Many of the risk factors for CKD begin in childhood. a patient develops CKD, the pathological changes that worsen dysfunction are similar in all kidney diseases, and are characterized by a process of ongoing scarring or fibrosis. Despite tremendous progress in our understanding of the causes and consequences of CKD, effective therapies are unknown. Using experimental models of CKD, our studies are designed to investigate how specific cells and molecules mediate kidney fibrosis, with the ultimate goal of translating our findings into new human therapies.
Standardised Outcomes in Nephrology-Children and Adolescents (SONG-Kids): a protocol for establishing a core outcome set for children with chronic kidney disease.
Tong A and Samuel S and Zappitelli M and Dart A and Furth S and Eddy A and Groothoff J and Webb NJ and Yap HK and Bockenhauer D and Sinha A and Alexander SI and Goldstein SL and Gipson DS and Hanson CS and Evangelidis N and Crowe S and Harris T and Hemmelgarn BR and Manns B
Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD.
Okamura DM and Bahrami NM and Ren S and Pasichnyk K and Williams JM and Gangoiti JA and Lopez-Guisa JM and Yamaguchi I and Barshop BA and Duffield JS and Eddy AA
The Canadian Childhood Nephrotic Syndrome (CHILDNEPH) Project: overview of design and methods.
Samuel S and Scott S and Morgan C and Dart A and Mammen C and Parekh R and Nettel-Aguirre A and Eddy A and Flynn R and Pinsk M and Wade A and Arora S and Benoit G and Bitzan M and Erickson R and Feber J and Filler G and Geier P and Girardin C and Grisaru S
Acute kidney injury and its association with in-hospital mortality among children with acute infections.
Imani PD and Odiit A and Hingorani SR and Weiss NS and Eddy AA
Social paediatrics: From 'lip service' to the health and well-being of Canada's children and youth.
Daneman D and Kellner J and Bernstein M and Dow K and Dugas MA and Duffy C and Eddy A and Filler G and Frappier JY and Gilmour S and Givelichian L and Huang L and Rockman-Greenberg C and Shevell M and Vardy C and Walti H and Orrbine E and Williams M
Rising part-time work in the academic pediatric workforce in Canada.
Filler G and Givelichian L and Walti H and Piedboeuf B and Pediatric Chairs of Canada
Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2.
Chang AM and Ohse T and Krofft RD and Wu JS and Eddy AA and Pippin JW and Shankland SJ
Mannose receptor 2 attenuates renal fibrosis.
López-Guisa JM and Cai X and Collins SJ and Yamaguchi I and Okamura DM and Bugge TH and Isacke CM and Emson CL and Turner SM and Shankland SJ and Eddy AA
Vascular endothelial cadherin modulates renal interstitial fibrosis.
Yamaguchi I and Tchao BN and Burger ML and Yamada M and Hyodo T and Giampietro C and Eddy AA
Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis.
Okamura DM and Pasichnyk K and Lopez-Guisa JM and Collins S and Hsu DK and Liu FT and Eddy AA
Nicotinic acetylcholine receptor a1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy.
Zhang G and Thomas AL and Marshall AL and Kernan KA and Su Y and Zheng Y and Takano J and Saido TC and Eddy AA
A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis.
Zhang G and Kernan KA and Thomas A and Collins S and Song Y and Li L and Zhu W and Leboeuf RC and Eddy AA
Serine proteases, inhibitors and receptors in renal fibrosis.
CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD.
Okamura DM and Pennathur S and Pasichnyk K and López-Guisa JM and Collins S and Febbraio M and Heinecke J and Eddy AA
Phase I trial of rosiglitazone in FSGS: I. Report of the FONT Study Group.
Joy MS and Gipson DS and Dike M and Powell L and Thompson A and Vento S and Eddy A and Fogo AB and Kopp JB and Cattran D and Trachtman H
Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy.
Tang SC and Leung JC and Chan LY and Eddy AA and Lai KN
Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury.
Okamura DM and López-Guisa JM and Koelsch K and Collins S and Eddy AA
Endogenous urokinase lacks antifibrotic activity during progressive renal injury.
Yamaguchi I and Lopez-Guisa JM and Cai X and Collins SJ and Okamura DM and Eddy AA
Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.
Zhang G and Kernan KA and Collins SJ and Cai X and López-Guisa JM and Degen JL and Shvil Y and Eddy AA
Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice.
Collins SJ and Alexander SL and Lopez-Guisa JM and Cai X and Maruvada R and Chua SC and Zhang G and Okamura DM and Matsuo S and Eddy AA
Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.
Matsuo S and López-Guisa JM and Cai X and Okamura DM and Alpers CE and Bumgarner RE and Peters MA and Zhang G and Eddy AA
Why is proteinuria an ominous biomarker of progressive kidney disease?
Zandi-Nejad K and Eddy AA and Glassock RJ and Brenner BM
Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: actions of an alternative urokinase receptor and LDL receptor-related protein.
Zhang G and Cai X and López-Guisa JM and Collins SJ and Eddy AA
The NPHP1 gene deletion associated with juvenile nephronophthisis is present in a subset of individuals with Joubert syndrome.
Parisi MA and Bennett CL and Eckert ML and Dobyns WB and Gleeson JG and Shaw DW and McDonald R and Eddy A and Chance PF and Glass IA
Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy.
Zhang G and Kim H and Cai X and López-Guisa JM and Alpers CE and Liu Y and Carmeliet P and Eddy AA
Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy.
Zhang G and Kim H and Cai X and Lopez-Guisa JM and Carmeliet P and Eddy AA
Longterm followup of childhood lupus nephritis.
Hagelberg S and Lee Y and Bargman J and Mah G and Schneider R and Laskin C and Eddy A and Gladman D and Urowitz M and Hebert D and Silverman E
Plasminogen activator inhibitor-1 and the kidney.
PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction.
Oda T and Jung YO and Kim HS and Cai X and López-Guisa JM and Ikeda Y and Eddy AA
TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy.
Kim H and Oda T and López-Guisa J and Wing D and Edwards DR and Soloway PD and Eddy AA
Role of cellular infiltrates in response to proteinuria.
Interstitial fibrosis in mice with overload proteinuria: deficiency of TIMP-1 is not protective.
Eddy AA and Kim H and López-Guisa J and Oda T and Soloway PD
Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature.
Vohra S and Eddy A and Levin AV and Taylor G and Laxer RM
The nephrotic syndrome: from the simple to the complex.
Eddy AA and Schnaper HW
Failure of antioxidant therapy to attenuate interstitial disease in rats with reversible nephrotic syndrome.
Drukker A and Eddy AA
Molecular insights into renal interstitial fibrosis.
Expression of genes that promote renal interstitial fibrosis in rats with proteinuria.
Antiribosomal P antibodies in pediatric patients with systemic lupus erythematosus and psychosis.
Press J and Palayew K and Laxer RM and Elkon K and Eddy A and Rakoff D and Silverman ED
An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes.
Zhang L and Eddy A and Teng YT and Fritzler M and Kluppel M and Melet F and Bernstein A
Neurologic manifestations of pediatric systemic lupus erythematosus.
Steinlin MI and Blaser SI and Gilday DL and Eddy AA and Logan WJ and Laxer RM and Silverman ED
Experimental insights into the tubulointerstitial disease accompanying primary glomerular lesions.
Protein restriction reduces transforming growth factor-beta and interstitial fibrosis in nephrotic syndrome.
Xanthogranulomatous pyelonephritis in children. Etiology, pathogenesis, clinical and radiologic features, and management.
Levy M and Baumal R and Eddy AA
Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats.
Jones CL and Buch S and Post M and McCulloch L and Liu E and Eddy AA
The contribution of antibody-mediated cytotoxicity and immune-complex formation to tubulointerstitial disease in passive Heymann nephritis.
Eddy AA and Ho GC and Thorner PS
Pulmonary hemorrhage and necrotizing glomerulonephritis without glomerular immune deposits: report of two cases.
Jones CL and Shields M and Eddy AA and Baumal R and O'Neill M and Geary DF
A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome.
Eddy AA and McCulloch L and Liu E and Adams J
Tubulointerstitial nephritis during the heterologous phase of nephrotoxic serum nephritis.
A study by immunofluorescence microscopy of the NC1 domain of collagen type IV in glomerular basement membranes of two patients with hereditary nephritis.
Thorner PS and Baumal R and Eddy A and Marrano PM
Interstitial nephritis induced by protein-overload proteinuria.
Prolongation of acute renal failure in two patients with hemolytic-uremic syndrome due to excessive plasma infusion therapy.
Eddy AA and Geary DF and Balfe JW and Clark WF and Baumal R
Characterization of the NC1 domain of collagen type IV in glomerular basement membranes (GBM) and of antibodies to GBM in a patient with anti-GBM nephritis.
Thorner PS and Baumal R and Eddy A and Marrano P
Identification of lymphohemopoietic cells in the kidneys of normal rats.
Eddy AA and Crary GS and Michael AF
Subtotal nephrectomy in the rabbit: a model of chronic hypercalcemia, nephrolithiasis, and obstructive nephropathy.
Eddy AA and Falk RJ and Sibley RK and Hostetter TH
Renal allograft failure due to recurrent dense intramembranous deposit disease.
Eddy A and Sibley R and Mauer SM and Kim Y
The distribution of the CR3 receptor on human cells and tissue as revealed by a monoclonal antibody.
Eddy A and Newman SL and Cosio F and LeBien T and Michael A
T32 DK07662 (Eddy PI). NIH/NRSA, Pediatric Nephrology Training Program, $274,895 current year. (2006-2016). The goal is to train academic pediatric nephrologists.
N/A (Okamura PI, Eddy Co-PI). Cystinosis Research Foundation, "Elucidating the Role of Cystinosin-Deficient Macrophages in Nephropathic Cystinosis", $218,966/2 years. (2011-2013). The goal of this project is to investigate the hypothesis that cystinosin deficiency leads to macrophage dysfunction that contributes to the pathogenesis of chronic kidney disease.
Pilot and Feasibility Grant (Eddy PI). Washington Global Health Alliance, Impact of Kidney Dysfunction on Mortality Rates in Ugandan Children Hospitalized with Acute Infections. $75,000. (2007-2010). The goal of this project is to establish a mechanism to evaluate renal function for children admitted to Mulago hospital with pneumonia, malaria and gastroenteritis and to determine the impact of renal failure on acute mortality rates.Honours & Awards
Elected to the Council of the International Society of Pediatric Nephrology (1995-2001) and the International Society of Nephrology (2009-2015).
Scientific Program Committee Co-chair for triannual congresses on the International Society of Pediatric Nephrology in 1989, 2011 and 2013.
First recipient of The Robert O. Hickman Endowed Chair in Pediatric Nephrology, University of Washington (2007-2012).Research Group Members
Olena Maydan, Research Assistant, Research Assistant