Bruce Carleton

Investigator, BC Children's Hospital
Director, Pharmaceutical Outcomes Programme, BC Children's Hospital
Division Head, Translational Therapeutics, Department of Pediatrics, University of British Columbia

The central theme of my research program, Pharmaceutical Outcomes and Policy Innovations (POPi), is the study of drug therapy with the goal of improving human health and quality of life.

I am particularly interested in developing models for evaluating drug effectiveness, medication use models designed to improve patient health, and effective surveillance systems to improve the safe use of medication.

I have a particular clinical interest in pediatric medicine and the variability in drug response. My labs use tools in pharmacogenomics, pharmacoepidemiology and pharmacokinetics in order to develop a systems pharmacology approach to drug problems. On the clinical side, I have an interest in the clinical management of patients who experience serious adverse drug reactions.

Another area of interest is the translation of knowledge to aid evidence-based drug policy development. POPi contributes to solving the international drug policy crisis on two levels: the public policy level (federal and provincial), and the clinical policy level. In this way the needs of government are served to manage drug budgets, the needs of clinicians to improve patient care, and the public need to understand and improve the effectiveness, safety and cost effectiveness of drugs.

Academic Affiliations

  • Professor, , Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Evidence to Innovation
  • Research Group(s): Clinical Pharmacology; Global Health and Innovations

Contact Information

Location

950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4

Grants

Identifying Clinical Pharmacogenomic Predictors for Antibiotic-associated Severe Cutaneous Adverse Drug Reactions

An International Cohort Pilot Study – BC Children’s Hospital Research Institute Evidence to Innovation Theme Seed Grant Award (2020 – 2021)

Severe Cutaneous Adverse Drug Reactions (SCAR) 2019 International Meeting

From Science to Translation – CIHR Planning and Dissemination Grant (2018 – 2019)

Genomic and Outcomes Databank for Pharmacogenomic and Implementation Studies (GO PGx) – Genome Canada, Genome BC, CIHR Large Scale Applied Research Project Competition

Genomics and Precision Medicine (2018 – 2022)

DSEN SEARCH & PREVENT - Active Surveillance and Evaluation of Adverse Reactions in Canadian Healthcare AND Pharmacogenomics of Adverse Reactions EVEnts Nation-wide Team (Renewal) – CIHR Drug Safety and Effectiveness Network (2014 – 2021)

Domperidone to stimulate milk production during lactation and potential risk of serious ventricular arrhythmia and/or sudden cardiac death – CIHR Drug Safety and Effectiveness Network (2018 – 2020)

Integrating pediatric pharmacogenomic testing into the Canadian health care system – Genome Canada Applications Partnership Program (2017 – 2020)

Assessing the Impact of Pharmacogenomic Testing in Pediatric Oncology – Child and Family Research Institute – Evidence to Innovation Seed Grant Funding (2015 – 2016)

Active surveillance for evaluation of harm of direct acting oral anticoagulants (DOACs) in real world patients – CIHR Drug Safety and Effectiveness Network (2015 – 2017)

Clinical and pharmacogenomic predictors of inter-patient variation in direct acting oral anticoagulant (DOAC) plasma concentrations in real-world patients – CHIR Drug Safety and Effectiveness Network (2015 – 2017)

The Drug Safety and Effectiveness Cross-Disciplinary Training (DSECT) program – CIHR Drug Safety and Effectiveness Network Training Grant (2015 – 2020)

Optimizing Chronic Hepatitis C Treatment Using Pharmacogenomic Biomarkers – CIHR Drug Safety and Effectiveness Network (2014 – 2015)

5-HT3 Antagonists (Antiemetics) & Cardiac Safety, Using an Active Surveillance Approach – CIHR Drug Safety and Effectiveness Network (2013 – 2015)

Implementation of A Pharmacogenetic ADR Prevention Program in BC – Genome British Columbia & BC Provincial Health Services Authority (2012 – 2015)

Honours & Awards

2019 Fellow of the American College of Clinical Pharmacology (ACCP)

2018 Fellow of the International Society for Pharmacoepidemiology (ISPE)

2016 Canadian Society of Pharmacology and Therapeutics (CSPT) Distinguished Service and Education Award

“Recognizing Leadership Excellence” Award for service as Chair, Data Stewardship Committee at the BC Ministry of Health from 2009 – 2014

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