Blair Leavitt
MD
Investigator, BC Children's Hospital
Senior Scientist, CMMT
Journal of Huntington's Disease
Muna Abedrabbo and Pardis Kazemian and Colm Connolly and Blair R Leavitt
DOI: 10.1177/1879639725133014408 / 2025
Trends in Neurosciences
Benjamin E. Life and Blair R. Leavitt
DOI: 10.1016/j.tins.2025.05.00407 / 2025
Brain and Behavior
Carlos Estevez-Fraga and Michael S. Elmalem and Marina Papoutsi and Alexandra Durr and Elin M. Rees and Nicola Z. Hobbs and Raymund A. C. Roos and Bernhard Landwehrmeyer and Blair R. Leavitt and Douglas R. Langbehn and Rachael I. Scahill and Geraint Rees and Sarah J. Tabrizi and Sarah Gregory
DOI: 10.1002/brb3.294004 / 2023
Current Research in Neurobiology
Benjamin Life and Luis E.B. Bettio and Ilse Gantois and Brian R. Christie and Blair R. Leavitt
DOI: 10.1016/j.crneur.2023.100094Laura Chan and Austin Hill and Ge Lu and Jeremy Van Raamsdonk and Randy D. Gascoyne and Michael R. Hayden and Blair R. Leavitt
DOI: 10.1101/2022.09.11.50744009 / 2022
Nature Nanotechnology
Jayesh A. Kulkarni and Dominik Witzigmann and Sarah B. Thomson and Sam Chen and Blair R. Leavitt and Pieter R. Cullis and Roy van der Meel
DOI: 10.1038/s41565-021-00937-w07 / 2021
Filipe B Rodrigues and Gail Owen and Swati Sathe and Elena Pak and Dipinder Kaur and Anka G Ehrhardt and Sherry Lifer and Jenny Townhill and Katarzyna Schubert and Blair R Leavitt and Mark Guttman and Jee Bang and Jan Lewerenz and Jamie Levey and Cristina Sampaio and Edward J Wild
DOI: 10.1101/2021.07.30.2126134007 / 2021
Nature Nanotechnology
Jayesh A. Kulkarni and Dominik Witzigmann and Sarah B. Thomson and Sam Chen and Blair R. Leavitt and Pieter R. Cullis and Roy van der Meel
DOI: 10.1038/s41565-021-00898-006 / 2021
Movement Disorders
Carlos Estevez-Fraga and Rachael I. Scahill and Alexandra Durr and Blair R. Leavitt and Raymund A.C. Roos and Douglas R. Langbehn and Geraint Rees and Sarah Gregory and Sarah J. Tabrizi
DOI: 10.1002/mds.2848905 / 2021
JAMA neurology
DOI: 10.1001/jamaneurol.2020.0299 PubMed: 3220259403 / 2020
Human molecular genetics
Laroche, M and Lessard-Beaudoin, M and Garcia-Miralles, M and Kreidy, C and Peachey, Emma and Leavitt, Blair R and Pouladi, MA and Graham, RK
DOI: 10.1093/hmg/ddaa099Nanoscale
Jayesh A. Kulkarni and Sarah B. Thomson and Josh Zaifman and Jerry Leung and Pamela K. Wagner and Austin Hill and Yuen Yi C. Tam and Pieter R. Cullis and Terri L. Petkau and Blair R. Leavitt
DOI: 10.1039/D0NR06816KPsychological medicine
Andrews, SC and Langbehn, DR and Craufurd, D and Durr, A and Leavitt, BR and Roos, RA and Tabrizi, SJ and Stout, JC and {TRACK-HD Investigators}
DOI: 10.1017/s0033291720000094Journal of magnetic resonance imaging : JMRI
Gregory, Sarah and Lohse, Keith R and Johnson, Eileanoir B and Leavitt, Blair R and Durr, Alexandra and Roos, Raymund A C and Rees, Geraint and Tabrizi, Sarah J and Scahill, Rachael I and Orth, Michael
DOI: 10.1002/jmri.27203Science (New York, N.Y.)
Leavitt, Blair R and Tabrizi, Sarah J
DOI: 10.1126/science.aba4624EBioMedicine
DOI: 10.1016/j.ebiom.2019.09.020 PubMed: 3160759810 / 2019
JAMA neurology
DOI: 10.1001/jamaneurol.2019.2368 PubMed: 3140368008 / 2019
The New England journal of medicine
DOI: 10.1056/nejmoa1900907 PubMed: 3105964105 / 2019
Journal of neuroscience methods
Kosior, Natalia and Petkau, Terri L and Connolly, Colm and Lu, Ge and Leavitt, Blair R
DOI: 10.1016/j.jneumeth.2019.108422Human molecular genetics
Petkau, Terri L and Hill, Austin and Connolly, Colm and Lu, Ge and Wagner, Pam and Kosior, Natalia and Blanco, Jake and Leavitt, Blair R
DOI: 10.1093/hmg/ddz009Movement Disorders Clinical Practice
Ross, Christopher A and Reilmann, Ralf and Cardoso, Francisco and McCusker, Elizabeth A and Testa, Claudia M and Stout, Julie C and Leavitt, Blair R and Pei, Zhong and Landwehrmeyer, Bernhard and Martinez, Asuncion and Levey, Jamie and Srajer, Teresa and Bang, Jee and Tabrizi, Sarah J
DOI: 10.1002/mdc3.12808Neuron
Tabrizi, Sarah J and Ghosh, Rhia and Leavitt, Blair R
DOI: 10.1016/j.neuron.2019.01.039Neuropsychology
Sophie C. Andrews and David Craufurd and Alexandra Durr and Blair R. Leavitt and Raymund A. Roos and Sarah J. Tabrizi and Julie C. Stout
DOI: 10.1037/neu000047911 / 2018
Journal of Huntington's disease
DOI: 10.3233/jhd-170272 PubMed: 3010333901 / 2018
Neurology
DOI: 10.1212/wnl.0000000000005005 PubMed: 2936744401 / 2018
Biological Psychiatry
McColgan, Peter and Gregory, Sarah and Seunarine, Kiran K and Razi, Adeel and Papoutsi, Marina and Johnson, Eileanoir and Durr, Alexandra and Roos, Raymund A C and Leavitt, Blair R and Holmans, Peter and Scahill, Rachael I and Clark, Chris A and Rees, Geraint and Tabrizi, Sarah J and {Track-On HD Investigators}
DOI: 10.1016/j.biopsych.2017.10.019Methods in molecular biology (Clifton, N.J.)
Kosior, Natalia and Leavitt, Blair R
DOI: 10.1007/978-1-4939-7825-0_10NeuroImage. Clinical
Minkova, Lora and Gregory, Sarah and Scahill, Rachael I and Abdulkadir, Ahmed and Kaller, Christoph P and Peter, Jessica and Long, Jeffrey D and Stout, Julie C and Reilmann, Ralf and Roos, Raymund A and Durr, Alexandra and Leavitt, Blair R and Tabrizi, Sarah J and Klppel, Stefan and {TRACK-HD Investigators}
DOI: 10.1016/j.nicl.2017.10.023Frontiers in neuroscience
Rowley, Christopher D and Tabrizi, Sarah J and Scahill, Rachael I and Leavitt, Blair R and Roos, Raymund A C and Durr, Alexandra and Bock, Nicholas A
DOI: 10.3389/fnins.2018.00805Brain : a journal of neurology
Gregory, Sarah and Long, Jeffrey D and Klppel, Stefan and Razi, Adeel and Scheller, Elisa and Minkova, Lora and Johnson, Eileanoir B and Durr, Alexandra and Roos, Raymund A C and Leavitt, Blair R and Mills, James A and Stout, Julie C and Scahill, Rachael I and Tabrizi, Sarah J and Rees, Geraint and {Track-On investigators}
DOI: 10.1093/brain/awy122Journal of Huntington's disease
Thomson, Sarah B and Leavitt, Blair R
DOI: 10.3233/jhd-180331Journal of Huntington's disease
Thompson, Leslie and Leavitt, Blair R
DOI: 10.3233/jhd-189000JAMA neurology
DOI: 10.1001/jamaneurol.2017.2107 PubMed: 2897527811 / 2017
Journal of neuroinflammation
DOI: 10.1186/s12974-017-1000-9 PubMed: 2914989911 / 2017
Movement disorders : official journal of the Movement Disorder Society
DOI: 10.1002/mds.27122 PubMed: 2890603109 / 2017
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1614943114 PubMed: 2853337505 / 2017
Neuroscience
DOI: 10.1016/j.neuroscience.2017.03.051 PubMed: 2839101304 / 2017
Human brain mapping
DOI: 10.1002/hbm.23527 PubMed: 2829445703 / 2017
Journal of Huntington's disease
DOI: 10.3233/jhd-170269 PubMed: 2912549301 / 2017
Annals of clinical and translational neurology
DOI: 10.1002/acn3.384 PubMed: 2816821001 / 2017
Frontiers in neurology
Johnson, Eileanoir B and Gregory, Sarah and Johnson, Hans J and Durr, Alexandra and Leavitt, Blair R and Roos, Raymund A and Rees, Geraint and Tabrizi, Sarah J and Scahill, Rachael I
DOI: 10.3389/fneur.2017.00519The Lancet. Neurology
Byrne, Lauren M and Rodrigues, Filipe B and Blennow, Kaj and Durr, Alexandra and Leavitt, Blair R and Roos, Raymund A C and Scahill, Rachael I and Tabrizi, Sarah J and Zetterberg, Henrik and Langbehn, Douglas and Wild, Edward J
DOI: 10.1016/s1474-4422(17)30124-2Journal of Huntington's disease
Leavitt, Blair R and Thompson, Leslie M
DOI: 10.3233/jhd-179003Brain : a journal of neurology
Gregory, Sarah and Long, Jeffrey D and Klppel, Stefan and Razi, Adeel and Scheller, Elisa and Minkova, Lora and Papoutsi, Marina and Mills, James A and Durr, Alexandra and Leavitt, Blair R and Roos, Raymund A C and Stout, Julie C and Scahill, Rachael I and Langbehn, Douglas R and Tabrizi, Sarah J and Rees, Geraint
DOI: 10.1093/brain/awx022Neurology
Schobel, Scott A and Palermo, Giuseppe and Auinger, Peggy and Long, Jeffrey D and Ma, Shiyang and Khwaja, Omar S and Trundell, Dylan and Cudkowicz, Merit and Hersch, Steven and Sampaio, Cristina and Dorsey, E Ray and Leavitt, Blair R and Kieburtz, Karl D and Sevigny, Jeffrey J and Langbehn, Douglas R and Tabrizi, Sarah J and {TRACK-HD, COHORT, CARE-HD, and 2CARE Huntington Study Group Investigators}
DOI: 10.1212/wnl.0000000000004743Handbook of clinical neurology
Kay, Chris and Hayden, Michael R and Leavitt, Blair R
DOI: 10.1016/b978-0-12-801893-4.00003-1JCI insight
McColgan, Peter and Seunarine, Kiran K and Gregory, Sarah and Razi, Adeel and Papoutsi, Marina and Long, Jeffrey D and Mills, James A and Johnson, Eileanoir and Durr, Alexandra and Roos, Raymund Ac and Leavitt, Blair R and Stout, Julie C and Scahill, Rachael I and Clark, Chris A and Rees, Geraint and Tabrizi, Sarah J and {Track-On HD Investigators}
DOI: 10.1172/jci.insight.92641Brain stimulation
Brown, KE and Lohse, KR and Mayer, IMS and Strigaro, G and Desikan, M and Casula, EP and Meunier, S and Popa, T and Lamy, J-C and Odish, O and Leavitt, BR and Durr, A and Roos, RAC and Tabrizi, SJ and Rothwell, JC and Boyd, LA and Orth, M
DOI: 10.1016/j.brs.2017.07.011The Lancet. Neurology
Moss, Davina J Hensman and Pardias, Antonio F and Langbehn, Douglas and Lo, Kitty and Leavitt, Blair R and Roos, Raymund and Durr, Alexandra and Mead, Simon and {TRACK-HD investigators} and {REGISTRY investigators} and Holmans, Peter and Jones, Lesley and Tabrizi, Sarah J
DOI: 10.1016/s1474-4422(17)30161-8Neurobiology of disease
Petkau, Terri L and Blanco, Jake and Leavitt, Blair R
DOI: 10.1016/j.nbd.2017.06.012The Journal of experimental medicine
DOI: 10.1084/jem.20160776 PubMed: 2782155311 / 2016
Human brain mapping
DOI: 10.1002/hbm.23332 PubMed: 2747732308 / 2016
Journal of the International Neuropsychological Society : JINS
DOI: 10.1017/s1355617716000321 PubMed: 2721110905 / 2016
Neuroscience
DOI: 10.1016/j.neuroscience.2016.03.031 PubMed: 2703397903 / 2016
Human molecular genetics
De Souza, Rebecca A G and Islam, Sumaiya A and McEwen, Lisa M and Mathelier, Anthony and Hill, Austin and Mah, Sarah M and Wasserman, Wyeth W and Kobor, Michael S and Leavitt, Blair R
DOI: 10.1093/hmg/ddw076Journal of neurochemistry
Rodrigues, Filipe Brogueira and Byrne, Lauren and McColgan, Peter and Robertson, Nicola and Tabrizi, Sarah J and Leavitt, Blair R and Zetterberg, Henrik and Wild, Edward J
DOI: 10.1111/jnc.13719Neuroscience
DOI: 10.1016/j.neuroscience.2015.12.006 PubMed: 2670129612 / 2015
Human Brain Mapping
DOI: 10.1002/hbm.23014 PubMed: 2645390210 / 2015
EBioMedicine
DOI: 10.1016/j.ebiom.2015.08.002 PubMed: 2662953608 / 2015
Neuroscience letters
DOI: 10.1016/j.neulet.2015.05.007 PubMed: 2595756105 / 2015
Current topics in behavioral neurosciences
DOI: 10.1007/7854_2014_353 PubMed: 2520532701 / 2015
The Journal of neuropsychiatry and clinical neurosciences
DOI: 10.1176/appi.neuropsych.13070169 PubMed: 2571648801 / 2015
Journal of Huntington's disease
Mazarei, Gelareh and Leavitt, Blair R
DOI: 10.3233/jhd-159003Frontiers in human neuroscience
Minkova, Lora and Scheller, Elisa and Peter, Jessica and Abdulkadir, Ahmed and Kaller, Christoph P and Roos, Raymund A and Durr, Alexandra and Leavitt, Blair R and Tabrizi, Sarah J and Klppel, Stefan and {TrackOn-HD Investigators}
DOI: 10.3389/fnhum.2015.00634The Journal of neuropsychiatry and clinical neurosciences
Howard, Andrew K and Krishnamoorthy, Ashok and Leavitt, Blair R and Raymond, Lynn A and Weissman, Cory R
DOI: 10.1176/appi.neuropsych.14090232Movement disorders : official journal of the Movement Disorder Society
Sturrock, Aaron and Laule, Corree and Wyper, Katy and Milner, Ruth A and Decolongon, Joji and Dar Santos, Rachelle and Coleman, Allison J and Carter, Kimberley and Creighton, Susan and Bechtel, Natalie and Bohlen, Stefan and Reilmann, Ralf and Johnson, Hans J and Hayden, Michael R and Tabrizi, Sarah J and Mackay, Alex L and Leavitt, Blair R
DOI: 10.1002/mds.26118Nature neuroscience
Becanovic, Kristina and Nrremlle, Anne and Neal, Scott J and Kay, Chris and Collins, Jennifer A and Arenillas, David and Lilja, Tobias and Gaudenzi, Giulia and Manoharan, Shiana and Doty, Crystal N and Beck, Jessalyn and Lahiri, Nayana and Portales-Casamar, Elodie and Warby, Simon C and Connolly, Colm and De Souza, Rebecca A G and {REGISTRY Investigators of the European Huntington's Disease Network} and Tabrizi, Sarah J and Hermanson, Ola and Langbehn, Douglas R and Hayden, Michael R and Wasserman, Wyeth W and Leavitt, Blair R
DOI: 10.1038/nn.4014Scientific reports
Southwell, Amber L and Smith, Stephen E P and Davis, Tessa R and Caron, Nicholas S and Villanueva, Erika B and Xie, Yuanyun and Collins, Jennifer A and Ye, Min Li and Sturrock, Aaron and Leavitt, Blair R and Schrum, Adam G and Hayden, Michael R
DOI: 10.1038/srep12166Nature Reviews. Disease Primers
Bates, Gillian P and Dorsey, Ray and Gusella, James F and Hayden, Michael R and Kay, Chris and Leavitt, Blair R and Nance, Martha and Ross, Christopher A and Scahill, Rachael I and Wetzel, Ronald and Wild, Edward J and Tabrizi, Sarah J
DOI: 10.1038/nrdp.2015.5The Journal of clinical investigation
Wild, Edward J and Boggio, Roberto and Langbehn, Douglas and Robertson, Nicola and Haider, Salman and Miller, James R C and Zetterberg, Henrik and Leavitt, Blair R and Kuhn, Rainer and Tabrizi, Sarah J and Macdonald, Douglas and Weiss, Andreas
DOI: 10.1172/jci80743Journal of neurochemistry
Wagner, Leona and Wolf, Raik and Zeitschel, Ulrike and Rossner, Steffen and Petersn, sa and Leavitt, Blair R and Kstner, Florian and Rothermundt, Matthias and Grtner, Ulf-Torsten and Gndel, Daniel and Schlenzig, Dagmar and Frerker, Nadine and Schade, Jutta and Manhart, Susanne and Rahfeld, Jens-Ulrich and Demuth, Hans-Ulrich and von Hrsten, Stephan
DOI: 10.1111/jnc.13378Neuropsychologia
Johnson, Eileanoir B and Rees, Elin M and Labuschagne, Izelle and Durr, Alexandra and Leavitt, Blair R and Roos, Raymund A C and Reilmann, Ralf and Johnson, Hans and Hobbs, Nicola Z and Langbehn, Douglas R and Stout, Julie C and Tabrizi, Sarah J and Scahill, Rachael I and {TRACK-HD investigators}
DOI: 10.1016/j.neuropsychologia.2015.10.033The Lancet. Neurology
DOI: 10.1016/s1474-4422(14)70262-5 PubMed: 2546784811 / 2014
Neurobiology of disease
DOI: 10.1016/j.nbd.2014.10.012 PubMed: 2544723010 / 2014
Movement disorders : official journal of the Movement Disorder Society
DOI: 10.1002/mds.26017 PubMed: 2516485908 / 2014
Journal of neurochemistry
DOI: 10.1111/jnc.12739 PubMed: 2471700905 / 2014
Endocrinology
DOI: 10.1210/en.2014-1031 PubMed: 2479763105 / 2014
NeuroImage
DOI: 10.1016/j.neuroimage.2014.04.057 PubMed: 2479174604 / 2014
Nature reviews. Neurology
DOI: 10.1038/nrneurol.2014.24 PubMed: 2461451603 / 2014
Journal of Huntington's disease
DOI: 10.3233/jhd-140101 PubMed: 2506286201 / 2014
Trends in neurosciences
Petkau, Terri L and Leavitt, Blair R
DOI: 10.1016/j.tins.2014.04.003Movement disorders : official journal of the Movement Disorder Society
Reilmann, Ralf and Leavitt, Blair R and Ross, Christopher A
DOI: 10.1002/mds.26011Journal of Huntington's disease
Plecash, Alyson R and Leavitt, Blair R
DOI: 10.3233/jhd-140010Human molecular genetics
Ehrnhoefer, Dagmar E and Skotte, Niels H and Ladha, Safia and Nguyen, Yen T N and Qiu, Xiaofan and Deng, Yu and Huynh, Khuong T and Engemann, Sabine and Nielsen, Signe M and Becanovic, Kristina and Leavitt, Blair R and Hasholt, Lis and Hayden, Michael R
DOI: 10.1093/hmg/ddt458European journal of human genetics : EJHG
DOI: 10.1038/ejhg.2013.206 PubMed: 2410537510 / 2013
Movement disorders : official journal of the Movement Disorder Society
DOI: 10.1002/mds.25663 PubMed: 2414239310 / 2013
Journal of Huntington's disease
DOI: 10.3233/jhd-130003 PubMed: 2505710601 / 2013
JAMA neurology
{HORIZON Investigators of the Huntington Study Group and European Huntington's Disease Network}
DOI: 10.1001/2013.jamaneurol.382Alzheimer's & dementia : the journal of the Alzheimer's Association
Boxer, Adam L and Gold, Michael and Huey, Edward and Hu, William T and Rosen, Howard and Kramer, Joel and Gao, Fen-Biao and Burton, Edward A and Chow, Tiffany and Kao, Aimee and Leavitt, Blair R and Lamb, Bruce and Grether, Megan and Knopman, David and Cairns, Nigel J and Mackenzie, Ian R and Mitic, Laura and Roberson, Erik D and Van Kammen, Daniel and Cantillon, Marc and Zahs, Kathleen and Jackson, George and Salloway, Stephen and Morris, John and Tong, Gary and Feldman, Howard and Fillit, Howard and Dickinson, Susan and Khachaturian, Zaven S and Sutherland, Margaret and Abushakra, Susan and Lewcock, Joseph and Farese, Robert and Kenet, Robert O and Laferla, Frank and Perrin, Steve and Whitaker, Steve and Honig, Lawrence and Mesulam, Marsel M and Boeve, Brad and Grossman, Murray and Miller, Bruce L and Cummings, Jeffrey L
DOI: 10.1016/j.jalz.2012.03.003Human brain mapping
Scahill, Rachael I and Hobbs, Nicola Z and Say, Miranda J and Bechtel, Natalie and Henley, Susie M D and Hyare, Harpreet and Langbehn, Douglas R and Jones, Rebecca and Leavitt, Blair R and Roos, Raymund A C and Durr, Alexandra and Johnson, Hans and Lehricy, Stphane and Craufurd, David and Kennard, Christopher and Hicks, Stephen L and Stout, Julie C and Reilmann, Ralf and Tabrizi, Sarah J and {TRACK-HD investigators}
DOI: 10.1002/hbm.21449Neurobiology of aging
Petkau, Terri L and Zhu, Shanshan and Lu, Ge and Fernando, Sarah and Cynader, Max and Leavitt, Blair R
DOI: 10.1016/j.neurobiolaging.2013.04.019Brain research
Zhu, Shanshan and Tai, Chao and Petkau, Terri L and Zhang, Si and Liao, Chengyong and Dong, Zhifang and Wen, Wendy and Chang, Qing and Tian Wang, Yu and MacVicar, Brian A and Leavitt, Blair R and Jia, William and Cynader, Max S
DOI: 10.1016/j.brainres.2013.07.023Nature communications
Park, Kevin H J and Franciosi, Sonia and Leavitt, Blair R
DOI: 10.1038/ncomms3906Journal of neurochemistry
Mazarei, Gelareh and Budac, David P and Lu, Ge and Adomat, Hans and Tomlinson Guns, Emma S and Mller, Thomas and Leavitt, Blair R
DOI: 10.1111/jnc.12350The Lancet. Neurology
Tabrizi, Sarah J and Scahill, Rachael I and Owen, Gail and Durr, Alexandra and Leavitt, Blair R and Roos, Raymund A and Borowsky, Beth and Landwehrmeyer, Bernhard and Frost, Chris and Johnson, Hans and Craufurd, David and Reilmann, Ralf and Stout, Julie C and Langbehn, Douglas R and {TRACK-HD Investigators}
DOI: 10.1016/s1474-4422(13)70088-7Journal of Huntington's disease
Crawford, Helen E and Hobbs, Nicola Z and Keogh, Ruth and Langbehn, Douglas R and Frost, Chris and Johnson, Hans and Landwehrmeyer, Bernhard and Reilmann, Ralf and Craufurd, David and Stout, Julie C and Durr, Alexandra and Leavitt, Blair R and Roos, Raymund A C and Tabrizi, Sarah J and Scahill, Rachael I and {TRACK-HD Investigators}'s disease
DOI: 10.3233/jhd-130077Neurology
Borowsky, Beth and Warner, John and Leavitt, Blair R and Tabrizi, Sarah J and Roos, Raymund A C and Durr, Alexandra and Becker, Chris and Sampaio, Cristina and Tobin, Allan J and Schulman, Howard
DOI: 10.1212/wnl.0b013e318293e1a1Experimental neurology
Mazarei, G and Budac, DP and Lu, G and Lee, H and Mller, T and Leavitt, BR
DOI: 10.1016/j.expneurol.2013.08.007Journal of Huntington's disease
Read, Joy and Jones, Rebecca and Owen, Gail and Leavitt, Blair R and Coleman, Allison and Roos, Raymund A C and Dumas, Eve M and Durr, Alexandra and Justo, Damian and Say, Miranda and Stout, Julie C and Tabrizi, Sarah J and Craufurd, David and {TRACK-HD investigators}'s disease
DOI: 10.3233/jhd-130051Alzheimer's & dementia : the journal of the Alzheimer's Association
DOI: 10.1016/j.jalz.2012.03.002 PubMed: 2304390010 / 2012
Neurobiology of disease
DOI: 10.1016/j.nbd.2012.02.012 PubMed: 2241478203 / 2012
Journal of Huntington's disease
DOI: 10.3233/jhd-2012-129000 PubMed: 2435374801 / 2012
Neurobiology of disease
Petkau, Terri L and Neal, Scott J and Milnerwood, Austen and Mew, Ada and Hill, Austin M and Orban, Paul and Gregg, Jenny and Lu, Ge and Feldman, Howard H and Mackenzie, Ian R A and Raymond, Lynn A and Leavitt, Blair R
DOI: 10.1016/j.nbd.2011.10.016Human molecular genetics
Tang, Bin and Becanovic, Kristina and Desplats, Paula A and Spencer, Brian and Hill, Austin M and Connolly, Colum and Masliah, Eliezer and Leavitt, Blair R and Thomas, Elizabeth A
DOI: 10.1093/hmg/dds132Journal of neurology, neurosurgery, and psychiatry
Stout, Julie C and Jones, Rebecca and Labuschagne, Izelle and O'Regan, Alison M and Say, Miranda J and Dumas, Eve M and Queller, Sarah and Justo, Damian and Santos, Rachelle Dar and Coleman, Allison and Hart, Ellen P and Drr, Alexandra and Leavitt, Blair R and Roos, Raymund A and Langbehn, Doug R and Tabrizi, Sarah J and Frost, Chris
DOI: 10.1136/jnnp-2011-301940Neurobiology of disease
Franciosi, Sonia and Ryu, Jae K and Shim, Yaein and Hill, Austin and Connolly, Colum and Hayden, Michael R and McLarnon, James G and Leavitt, Blair R
DOI: 10.1016/j.nbd.2011.09.003Journal of Huntington's disease
Dumas, Eve M and Say, Miranda J and Jones, Rebecca and Labuschagne, Izelle and O'Regan, Alison M and Hart, Ellen P and van den Bogaard, Simon J A and Queller, Sarah and Justo, Damian and Coleman, Allison and Dar Santos, Rachelle C and Drr, Alexandra and Leavitt, Blair R and Tabrizi, Sarah J and Roos, Raymund A C and Stout, Julie C
DOI: 10.3233/jhd-2012-120010Journal of Huntington's disease
Leavitt, Blair R and Thompson, Leslie M
DOI: 10.3233/jhd-2012-120001Neurobiology of aging
DOI: 10.1016/j.neurobiolaging.2011.05.020 PubMed: 2174112607 / 2011
The Lancet. Neurology
DOI: 10.1016/s1474-4422(11)70070-9 PubMed: 2160116406 / 2011
Cancer research
Fotovati, Abbas and Abu-Ali, Samah and Wang, Pei-Shan and Deleyrolle, Loic P and Lee, Cathy and Triscott, Joanna and Chen, James Y and Franciosi, Sonia and Nakamura, Yasuhiro and Sugita, Yasuo and Uchiumi, Takeshi and Kuwano, Michihiko and Leavitt, Blair R and Singh, Sheila K and Jury, Alexa and Jones, Chris and Wakimoto, Hiroaki and Reynolds, Brent A and Pallen, Catherine J and Dunn, Sandra E
DOI: 10.1158/0008-5472.can-10-2805The Lancet. Neurology
Tabrizi, Sarah J and Scahill, Rachael I and Durr, Alexandra and Roos, Raymund Ac and Leavitt, Blair R and Jones, Rebecca and Landwehrmeyer, G Bernhard and Fox, Nick C and Johnson, Hans and Hicks, Stephen L and Kennard, Christopher and Craufurd, David and Frost, Chris and Langbehn, Douglas R and Reilmann, Ralf and Stout, Julie C and {TRACK-HD Investigators}
DOI: 10.1016/s1474-4422(10)70276-3Movement disorders : official journal of the Movement Disorder Society
Hobbs, Nicola Z and Pedrick, Amy V and Say, Miranda J and Frost, Chris and Dar Santos, Rachelle and Coleman, Allison and Sturrock, Aaron and Craufurd, David and Stout, Julie C and Leavitt, Blair R and Barnes, Josephine and Tabrizi, Sarah J and Scahill, Rachael I
DOI: 10.1002/mds.23747Neurology
DOI: 10.1212/wnl.0b013e3181fc27e4 PubMed: 2106009311 / 2010
Human molecular genetics
Pouladi, Mahmoud A and Xie, Yuanyun and Skotte, Niels Henning and Ehrnhoefer, Dagmar E and Graham, Rona K and Kim, Jeong Eun and Bissada, Nagat and Yang, X William and Paganetti, Paolo and Friedlander, Robert M and Leavitt, Blair R and Hayden, Michael R
DOI: 10.1093/hmg/ddq026The Journal of comparative neurology
Petkau, Terri L and Neal, SJ and Orban, PC and MacDonald, JL and Hill, AM and Lu, G and Feldman, HH and Mackenzie, I R A and Leavitt, BR
DOI: 10.1002/cne.22430Human molecular genetics
Becanovic, Kristina and Pouladi, Mahmoud A and Lim, Raymond S and Kuhn, Alexandre and Pavlidis, Paul and Luthi-Carter, Ruth and Hayden, Michael R and Leavitt, Blair R
DOI: 10.1093/hmg/ddq018Journal of geriatric psychiatry and neurology
Sturrock, Aaron and Leavitt, Blair R
DOI: 10.1177/0891988710383573Neurology
Bechtel, N and Scahill, RI and Rosas, HD and Acharya, T and van den Bogaard, S J A and Jauffret, C and Say, MJ and Sturrock, A and Johnson, H and Onorato, CE and Salat, DH and Durr, A and Leavitt, BR and Roos, R A C and Landwehrmeyer, GB and Langbehn, DR and Stout, JC and Tabrizi, SJ and Reilmann, R
DOI: 10.1212/wnl.0b013e3182020123The Journal of neuroscience : the official journal of the Society for Neuroscience
Metzler, Martina and Gan, Lu and Mazarei, Gelareh and Graham, Rona K and Liu, Lili and Bissada, Nagat and Lu, Ge and Leavitt, Blair R and Hayden, Michael R
DOI: 10.1523/jneurosci.1589-10.2010Human molecular genetics
DOI: 10.1093/hmg/ddp527 PubMed: 1993411411 / 2009
Proceedings of the National Academy of Sciences of the United States of America
Yeretssian, Garabet and Doiron, Karine and Shao, Wei and Leavitt, Blair R and Hayden, Michael R and Nicholson, Donald W and Saleh, Maya
DOI: 10.1073/pnas.0813362106The Journal of neuroscience : the official journal of the Society for Neuroscience
Graham, Rona K and Pouladi, Mahmoud A and Joshi, Prasad and Lu, Ge and Deng, Yu and Wu, Nan-Ping and Figueroa, Bryan E and Metzler, Martina and Andr, Vronique M and Slow, Elizabeth J and Raymond, Lynn and Friedlander, Robert and Levine, Michael S and Leavitt, Blair R and Hayden, Michael R
DOI: 10.1523/jneurosci.5473-08.2009Molecular & cellular proteomics : MCP
Fang, Qiaojun and Strand, Andrew and Law, Wendy and Faca, Vitor M and Fitzgibbon, Matthew P and Hamel, Nathalie and Houle, Benoit and Liu, Xin and May, Damon H and Poschmann, Gereon and Roy, Line and Sthler, Kai and Ying, Wantao and Zhang, Jiyang and Zheng, Zhaobin and Bergeron, John J M and Hanash, Sam and He, Fuchu and Leavitt, Blair R and Meyer, Helmut E and Qian, Xiaohong and McIntosh, Martin W
DOI: 10.1074/mcp.m800231-mcp200The Journal of neuroscience : the official journal of the Society for Neuroscience
Joshi, Prasad R and Wu, Nan-Ping and Andr, Vronique M and Cummings, Damian M and Cepeda, Carlos and Joyce, John A and Carroll, Jeffrey B and Leavitt, Blair R and Hayden, Michael R and Levine, Michael S and Bamford, Nigel S
DOI: 10.1523/jneurosci.5687-08.2009The Lancet. Neurology
Tabrizi, Sarah J and Langbehn, Douglas R and Leavitt, Blair R and Roos, Raymund Ac and Durr, Alexandra and Craufurd, David and Kennard, Christopher and Hicks, Stephen L and Fox, Nick C and Scahill, Rachael I and Borowsky, Beth and Tobin, Allan J and Rosas, H Diana and Johnson, Hans and Reilmann, Ralf and Landwehrmeyer, Bernhard and Stout, Julie C and {TRACK-HD investigators}
DOI: 10.1016/s1474-4422(09)70170-xNature reviews. Drug discovery
Hayden, Michael R and Leavitt, Blair R and Yasothan, Uma and Kirkpatrick, Peter
DOI: 10.1038/nrd2784The Journal of experimental medicine
DOI: 10.1084/jem.20080178 PubMed: 1862574807 / 2008
Movement disorders : official journal of the Movement Disorder Society
Semaka, Alicia and Warby, Simon and Leavitt, Blair R and Hayden, Michael R
DOI: 10.1002/mds.21820Movement disorders : official journal of the Movement Disorder Society
DOI: 10.1002/mds.21447 PubMed: 1772204510 / 2007
Journal of proteome research
DOI: 10.1021/pr0700753 PubMed: 1755255006 / 2007
Handbook of clinical neurology
DOI: 10.1016/s0072-9752(07)80018-2 PubMed: 1880890001 / 2007
BMC genomics
Butland, Stefanie L and Devon, Rebecca S and Huang, Yong and Mead, Carri-Lyn and Meynert, Alison M and Neal, Scott J and Lee, Soo Sen and Wilkinson, Anna and Yang, George S and Yuen, Macaire M S and Hayden, Michael R and Holt, Robert A and Leavitt, Blair R and Ouellette, B F Francis
DOI: 10.1186/1471-2164-8-126Neurobiology of disease
Van Raamsdonk, Jeremy M and Murphy, Zoe and Selva, David M and Hamidizadeh, Reza and Pearson, Jacqueline and Petersn, Asa and Bjrkqvist, Maria and Muir, Cameron and Mackenzie, Ian R and Hammond, Geoffrey L and Vogl, A Wayne and Hayden, Michael R and Leavitt, Blair R
DOI: 10.1016/j.nbd.2007.01.006The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Wong, D and Dwinnel, M and Schulzer, M and Nimmo, M and Leavitt, BR and Spacey, SD
DOI: 10.1017/s031716710000603xHuman molecular genetics
Kuhn, Alexandre and Goldstein, Darlene R and Hodges, Angela and Strand, Andrew D and Sengstag, Thierry and Kooperberg, Charles and Becanovic, Kristina and Pouladi, Mahmoud A and Sathasivam, Kirupa and Cha, Jang-Ho J and Hannan, Anthony J and Hayden, Michael R and Leavitt, Blair R and Dunnett, Stephen B and Ferrante, Robert J and Albin, Roger and Shelbourne, Peggy and Delorenzi, Mauro and Augood, Sarah J and Faull, Richard L M and Olson, James M and Bates, Gillian P and Jones, Lesley and Luthi-Carter, Ruth
DOI: 10.1093/hmg/ddm133Neurobiology of disease
DOI: 10.1016/j.nbd.2006.12.010 PubMed: 1727669212 / 2006
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0510197103 PubMed: 1676989406 / 2006
Neurobiology of disease
DOI: 10.1016/j.nbd.2006.02.011 PubMed: 1669765205 / 2006
Journal of neurochemistry
DOI: 10.1111/j.1471-4159.2005.03605.x PubMed: 1641758101 / 2006
Clinical genetics
Bjrkqvist, M and Petersn, A and Nielsen, J and Ecker, D and Mulder, H and Hayden, MR and Landwehrmeyer, B and Brundin, P and Leavitt, BR
DOI: 10.1111/j.1399-0004.2006.00636.xNature clinical practice. Neurology
Leavitt, Blair R and Hayden, Michael R
DOI: 10.1038/ncpneuro0299Neurobiology of disease
Shehadeh, Jacqueline and Fernandes, Herman B and Zeron Mullins, Melinda M and Graham, Rona K and Leavitt, Blair R and Hayden, Michael R and Raymond, Lynn A
DOI: 10.1016/j.nbd.2005.08.001The EMBO journal
Zhang, Yu and Leavitt, Blair R and van Raamsdonk, Jeremy M and Dragatsis, Ioannis and Goldowitz, Dan and MacDonald, Marcy E and Hayden, Michael R and Friedlander, Robert M
DOI: 10.1038/sj.emboj.7601445BMC neurology
Mackenzie, Ian R and Butland, Stefanie L and Devon, Rebecca S and Dwosh, Emily and Feldman, Howard and Lindholm, Caroline and Neal, Scott J and Ouellette, B F Francis and Leavitt, Blair R
DOI: 10.1186/1471-2377-6-32BMC neuroscience
Van Raamsdonk, Jeremy M and Pearson, Jacqueline and Murphy, Zoe and Hayden, Michael R and Leavitt, Blair R
DOI: 10.1186/1471-2202-7-80Cell
Graham, Rona K and Deng, Yu and Slow, Elizabeth J and Haigh, Brendan and Bissada, Nagat and Lu, Ge and Pearson, Jacqueline and Shehadeh, Jacqueline and Bertram, Lisa and Murphy, Zoe and Warby, Simon C and Doty, Crystal N and Roy, Sophie and Wellington, Cheryl L and Leavitt, Blair R and Raymond, Lynn A and Nicholson, Donald W and Hayden, Michael R
DOI: 10.1016/j.cell.2006.04.026Human molecular genetics
Van Raamsdonk, Jeremy M and Gibson, William T and Pearson, Jacqueline and Murphy, Zoe and Lu, Ge and Leavitt, Blair R and Hayden, Michael R
DOI: 10.1093/hmg/ddl072Neurobiology of disease
DOI: 10.1016/j.nbd.2005.08.007 PubMed: 1623001910 / 2005
Human molecular genetics
Van Raamsdonk, Jeremy M and Pearson, Jacqueline and Rogers, Daniel A and Bissada, Nagat and Vogl, A Wayne and Hayden, Michael R and Leavitt, Blair R
DOI: 10.1093/hmg/ddi147Experimental neurology
Van Raamsdonk, Jeremy M and Pearson, Jacqueline and Rogers, Daniel A and Lu, Ge and Barakauskas, Vilte E and Barr, Alasdair M and Honer, William G and Hayden, Michael R and Leavitt, Blair R
DOI: 10.1016/j.expneurol.2005.07.021Neurobiology of disease
Devon, Rebecca S and Schwab, Claudia and Topp, Justin D and Orban, Paul C and Yang, Yu-Zhou and Pape, Terry D and Helm, Jeffrey R and Davidson, Tara-Lynne and Rogers, Daniel A and Gros-Louis, Francois and Rouleau, Guy and Horazdovsky, Bruce F and Leavitt, Blair R and Hayden, Michael R
DOI: 10.1016/j.nbd.2004.10.002The Journal of neuroscience : the official journal of the Society for Neuroscience
Van Raamsdonk, Jeremy M and Pearson, Jacqueline and Slow, Elizabeth J and Hossain, Sazzad M and Leavitt, Blair R and Hayden, Michael R
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Pinto, John T and Van Raamsdonk, Jeremy M and Leavitt, Blair R and Hayden, Michael R and Jeitner, Thomas M and Thaler, Howard T and Krasnikov, Boris F and Cooper, Arthur J L
DOI: 10.1111/j.1471-4159.2005.03255.xBMC bioinformatics
Missirlis, Perseus I and Mead, Carri-Lyn R and Butland, Stefanie L and Ouellette, B F Francis and Devon, Rebecca S and Leavitt, Blair R and Holt, Robert A
DOI: 10.1186/1471-2105-6-145Neurology
Puri, BK and Leavitt, BR and Hayden, MR and Ross, CA and Rosenblatt, A and Greenamyre, JT and Hersch, S and Vaddadi, KS and Sword, A and Horrobin, DF and Manku, M and Murck, H
DOI: 10.1212/01.wnl.0000169025.09670.6dHuman molecular genetics
Van Raamsdonk, Jeremy M and Murphy, Zoe and Slow, Elizabeth J and Leavitt, Blair R and Hayden, Michael R
DOI: 10.1093/hmg/ddi407Journal of neurochemistry
Van Raamsdonk, Jeremy M and Pearson, Jacqueline and Bailey, Craig D C and Rogers, Daniel A and Johnson, Gail V W and Hayden, Michael R and Leavitt, Blair R
DOI: 10.1111/j.1471-4159.2005.03357.xProceedings of the National Academy of Sciences of the United States of America
Slow, Elizabeth J and Graham, Rona K and Osmand, Alexander P and Devon, Rebecca S and Lu, Ge and Deng, Yu and Pearson, Jacqui and Vaid, Kuljeet and Bissada, Nagat and Wetzel, Ronald and Leavitt, Blair R and Hayden, Michael R
DOI: 10.1073/pnas.0503634102Molecular and cellular neurosciences
DOI: 10.1016/j.mcn.2003.11.014 PubMed: 1503317503 / 2004
Expert review of neurotherapeutics
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Human molecular genetics
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Science (New York, N.Y.)
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Nature
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Journal of neural transmission. Supplementum
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Neuroreport
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Neuron
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The Laboratory for Experimental Therapeutics in Animal Models of Human Disease at the Centre for Molecular Medicine and Therapeutics (CMMT) is dedicated to developing new treatments for hereditary brain diseases, such as Huntington’s disease, Fragile X, and Frontotemporal dementia. Molecular genetic tools are used to generate transgenic animal models of these diseases. New approaches to treatment are then tested in these models, with the goal of accelerating the progress of new treatments from the bench to the clinic. This facility’s resources and expertise provide the basis for collaborative projects with scientists worldwide.
An important mouse model used in my laboratory is a Yeast Artificial chromosome (YAC) transgenic mouse model of Huntington’s Disease (HD) originally developed in Michael Hayden's laboratory at the CMMT. This mouse model faithfully replicates key features of the human disease; specifically these mice develop age-related motor dysfunction, behavioural abnormalities, and selective neurodegeneration of medium spiny neurons of the striatum. YAC transgenic mice have now been generated with the full-length human HD gene containing normal (YAC18) and expanded (YAC46, 72, and 128) CAG repeats. Different lines of transgenic mice have varying copy numbers of the human transgene and express varying amounts of transgenic huntingtin protein. The progressive motor and neurodegenerative phenotype of the YAC128 mouse model of HD makes in vivo screening of novel therapeutic approaches viable.
My laboratory includes a mouse behavioural testing unit allowing phenotypic characterization of large numbers of transgenic mice using a standardized behavioural protocol, as well as a dedicated small animal surgical suite allowing a variety of surgical procedures including administration of stem cells, compounds or gene therapy directly into the CNS. I’ve established a dedicated image analysis suite, stereology system, and automated neuropathology unit for high-throughput quantitative analysis of neurodegeneration in transgenic mouse brains.
Several trials of potential therapeutic agents have now been initiated in our YAC transgenic mouse model. Novel therapeutic approaches effective in our HD model will likely have utility in a broad range of neurodegenerative disorders. We currently are performing CRISPR-based gene therapy experiments using non-viral lipid nanoparticle delivery systems. I also have several ongoing projects investigating the role of wild-type huntingtin in neuronal apoptosis and a possible role for loss of huntingtin function in neurodevelopment and neurodegenerative disease.
In addition to my basic laboratory research, I’m a neurologist with an ongoing clinical practice and clinical research program in neurogenetics, with a focus on hereditary movement disorders, specifically various forms of ataxia and chorea. Together with Dr. Michael Hayden I lead thein post-mortem studies of HD patients as well as clinical research directed at identifying novel forms of CAG repeat disorders. I’m involved in clinical trials of new therapeutics in Huntington’s disease. I’m also the Director of Research at the UBC Centre for HD and Director of the Mouse Facility at the CMMT.
Young Investigator Award, Brain Research Centre, University of British Columbia, 1999
Award for Outstanding Achievement by a Postdoctoral Fellow, BC Research Institute for Children’s & Women’s Health, 2001
Michael Smith Foundation for Health Research Career Investigator Award, 2007
Every day, our researchers work towards breakthroughs to transform the lives of kids in BC and around the world. Learn about our latest innovations and advancements in child health.
Parents Ravi and Jenny first noticed that their daughter was starting to miss some development milestones when she was nine months old.
Congratulations to the BC Children's Hospital Research Institute (BCCHR) and Women's Health Research Institute (WHRI) investigators and their teams who were awarded funding through the Canadian Institutes of Health Research (CIHR) Spring 2022 Project Grant competition. Our research community received around $15 million in new research grants as principal investigators or co-investigators.
Congratulations to the BC Children's Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded funding through the Canadian Institutes of Health Research (CIHR) Fall 2021 Project Grant competition. Our research community received around $6 million in new research grants as principal investigators or co-investigators.
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