BCCHR Researchers Find a Researcher

Cheryl Wellington

PhD, BSc

Affiliate Investigator, BC Children's Hospital

Disorders of cholesterol metabolism underlie several human diseases, including heart disease and stroke. Recently, cholesterol metabolism has been recognized to play a major role in the pathogenesis of Alzheimer's disease. My laboratory studies genes that regulate cholesterol metabolism throughout the body, and as such we are at the interface between dementia and cardiovascular research.

Academic Affiliations

Professor, , Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia
Research Theme: Brain, Behaviour & Development
Research Group(s): Mental Health and Behaviour

Contact Information

Location

David Mowafaghian Centre for Brain Health and UBC Department of Pathology and Laboratory Medicine, 2215 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3

(604) 827-3769

cheryl.wellington@ubc.ca

Pharmacological inhibition of O-GlcNAcase reduces pS129-a-synuclein positive aggregates in the substantia nigra of mThy1-hSNCA mice

Journal of Parkinsons Disease

Jefferey Yue and Bryan Jones and Kim H Tran and Matthew Deen and Viktor Holicek and Wai Hang Cheng and Mateusz Michalik and Sarah Power and Cheryl L Wellington and Neil V Watson and David J Vocadlo

DOI: 10.1177/1877718X251410291

02 / 2026

Age dictates brain functional connectivity and axonal integrity following repetitive mild traumatic brain injuries in mice

NeuroImage

Marangelie Criado-Marrero and Sakthivel Ravi and Ekta Bhaskar and Daylin Barroso and Michael A. Pizzi and Lakiesha Williams and Cheryl L. Wellington and Marcelo Febo and Jose Francisco Abisambra

DOI: 10.1016/j.neuroimage.2024.120764

09 / 2024

Age dictates brain functional connectivity and axonal integrity following repetitive mild traumatic brain injuries

Marangelie Criado-Marrero and Sakthivel Ravi and Ekta Bhaskar and Daylin Barroso and Michael A. Pizzi and Lakiesha Williams and Cheryl L. Wellington and Marcelo Febo and Jose Francisco Abisambra

DOI: 10.1101/2024.01.25.577316

01 / 2024

Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia

Molecular Neurodegeneration

Tetiana Poliakova and Cheryl L. Wellington

DOI: 10.1186/s13024-023-00671-y

11 / 2023

Solving neurodegeneration: common mechanisms and strategies for new treatments

Molecular Neurodegeneration

DOI: 10.1186/S13024-022-00524-0

PDMS Organ-On-Chip Design and Fabrication: Strategies for Improving Fluidic Integration and Chip Robustness of Rapidly Prototyped Microfluidic In Vitro Models

Micromachines

DOI: 10.3390/MI13101573

Neurologic Prognostication After Cardiac Arrest Using Brain Biomarkers A Systematic Review and Meta-analysis

JAMA Neurology

DOI: 10.1001/JAMANEUROL.2021.5598

Prognostic peripheral blood biomarkers at ICU admission predict COVID-19 clinical outcomes

Frontiers in Immunology

DOI: 10.3389/FIMMU.2022.1010216

Diffusely abnormal white matter in clinically isolated syndrome is associated with parenchymal loss and elevated neurofilament levels

Multiple Sclerosis and Related Disorders

DOI: 10.1016/J.MSARD.2021.103422

Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway (vol 59, pg 830, 2018)

Journal of Lipid Research

DOI: 10.1016/J.JLR.2022.100214

Serum neurofilament light chain correlates with myelin and axonal magnetic resonance imaging markers in multiple sclerosis

Multiple Sclerosis and Related Disorders

DOI: 10.1016/J.MSARD.2021.103366

Persistently elevated complement alternative pathway biomarkers in COVID-19 correlate with hypoxemia and predict in-hospital mortality

Medical Microbiology and Immunology

DOI: 10.1007/S00430-021-00725-2

Blood Biomarkers of Brain Injury in Women who Have Experienced Intimate Partner Violence: A Pilot Study

Brain Injury

Altered tau in rTg4510 mice after a single interfaced CHIMERA traumatic brain injury

BioRxiv

DOI: 10.1101/2022.09.01.506145

Blood-based traumatic brain injury biomarkers - Clinical utilities and regulatory pathways in the United States, Europe and Canada

Expert Review of Molecular Diagnostics

DOI: 10.1080/14737159.2021.2005583

Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes

Blood Reviews

DOI: 10.1016/J.BLRE.2020.100707

Review of Design Considerations for Brain-on-a-Chip Models

Micromachines

DOI: 10.3390/MI12040441

Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol

Systematic Reviews

DOI: 10.1186/S13643-021-01703-8

CHIMERA TRAUMATIC BRAIN INJURY IN A MOUSE MODEL OF TAUOPATHY

Journal of Neurotrauma

Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest

Circulation Research

DOI: 10.1161/CIRCRESAHA.121.319157

Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

Cell Reports Medicine

DOI: 10.1016/J.XCRM.2021.100269

Characterization of Cerebrospinal Fluid Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) as a Biomarker of Human Acute Traumatic Spinal Cord Injury

Journal of Neurotrauma

DOI: 10.1089/NEU.2020.7352

Development of a novel, sensitive translational immunoassay to detect plasma glial fibrillary acidic protein (GFAP) after murine traumatic brain injury

Alzheimer's Research & Therapy

DOI: 10.1186/S13195-021-00793-9

Assessing the importance of interleukin-6 in COVID-19

The Lancet Respiratory Medicine

DOI: 10.1016/S2213-2600(20)30600-7

Correlations of Serum Neurofilaments with Myelin, Axonal and Volumetric Imaging Across the Multiple Sclerosis Spectrum

Multiple Sclerosis Journal

Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

European Respiratory Journal

DOI: 10.1183/13993003.03006-2020

Amelioration of COVID-19-related cytokine storm syndrome: parallels to chimeric antigen receptor-T cell cytokine release syndrome

British Journal of Haematology

DOI: 10.1111/BJH.16961

Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

DOI: 10.1002/ALZ.12157

An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases

Molecular Neurodegeneration

DOI: 10.1186/S13024-020-00418-Z

The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19

Blood Advances

DOI: 10.1182/BLOODADVANCES.2020002623

Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

Molecular Neurodegeneration

DOI: 10.1186/S13024-020-00366-8

An Automated Kinematic Measurement System for Sagittal Plane Murine Head Impacts

Journal of Biomechanical Engineering

DOI: 10.1115/1.4046202

Alternatives to amyloid for Alzheimer's disease therapies-a symposium report

Annals of the New York Academy of Sciences

DOI: 10.1111/NYAS.14371

Axl receptor tyrosine kinase is a regulator of apolipoprotein E

Molecular Brain

DOI: 10.1186/S13041-020-00609-1

Increased severity of the CHIMERA model induces acute vascular injury, sub-acute deficits in memory recall, and chronic white matter gliosis

Experimental Neurology

DOI: 10.1016/J.EXPNEUROL.2019.113116

Technique and preliminary findings for in vivo quantification of brain motion during injurious head impacts

Journal of Biomechanics

T. Whyte and J. Liu and V. Chung and S.A. McErlane and Z.A. Abebe and K.A. McInnes and C.L. Wellington and P.A. Cripton

DOI: 10.1016/j.jbiomech.2019.07.023

10 / 2019

A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease

Scientific Reports

DOI: 10.1038/S41598-019-46306-5

Primum non nocere: a call for balance when reporting on CTE

The Lancet Neurology

DOI: 10.1016/S1474-4422(19)30020-1

CHIMERA REPETITIVE MILD TBI INDUCES PTSD-LIKE BEHAVIOR AND CHRONIC NEUROPATHOLOGIES IN WILD-TYPE AND APP/ PS1 MICE

Journal of Neurotrauma

An End-to-end System for Automatic Characterization of Iba1 Immunopositive Microglia in Whole Slide Imaging

Neuroinformatics

DOI: 10.1007/S12021-018-9405-X

HDL from an Alzheimer's disease perspective

Current Opinion in Lipidology

DOI: 10.1097/MOL.0000000000000604

CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice

Alzheimer's Research & Therapy

DOI: 10.1186/S13195-018-0461-0

CHARACTERIZATION OF SERUM TOTAL TAU FOLLOWING PEDIATRIC TRAUMATIC BRAIN INJURY

Journal of Neurotrauma

Vascular dysfunction-The disregarded partner of Alzheimer's disease

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

DOI: 10.1016/J.JALZ.2018.07.222

MODERATE CHIMERA INJURY ELICITS DIFFERENTIAL ACUTE INFLAMMATORY RESPONSES IN HUMANIZED APOE3 AND APOE4 TARGETED-REPLACEMENT MICE

Journal of Neurotrauma

Vasoprotective Functions of High-Density Lipoproteins Relevant to Alzheimer's Disease Are Partially Conserved in Apolipoprotein B-Depleted Plasma

International Journal of Molecular Sciences

DOI: 10.3390/IJMS20030462

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

Alzheimer's & Dementia: Translational Research & Clinical Interventions

DOI: 10.1016/J.TRCI.2019.02.001

Repetitive closed-head impact model of engineered rotational acceleration (CHIMERA) injury in rats increases impulsivity, decreases dopaminergic innervation in the olfactory tubercle and generates white matter inflammation, tau phosphorylation and degeneration

Experimental Neurology

DOI: 10.1016/J.EXPNEUROL.2019.02.012

Characterisation of serum total tau following paediatric traumatic brain injury: a case-control study

The Lancet Child & Adolescent Health

DOI: 10.1016/S2352-4642(19)30194-4

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

Alzheimer's Research & Therapy

DOI: 10.1186/S13195-019-0497-9

Cerebral Microvascular Injury: A Potentially Treatable Endophenotype of Traumatic Brain Injury-Induced Neurodegeneration

Neuron

DOI: 10.1016/J.NEURON.2019.06.002

AN AUTOMATED KINEMATIC MEASUREMENT SYSTEM FOR USE WITH THE CHIMERA MURINE MODEL OF TRAUMATIC BRAIN INJURY

Journal of Neurotrauma

SERUM TOTAL TAU AS A DIAGNOSTIC AND PROGNOSTIC MARKER IN PEDIATRIC TRAUMATIC BRAIN INJURY

Journal of Neurotrauma

Military-related risk factors for dementia

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

DOI: 10.1016/J.JALZ.2018.08.011

ADDRESSING MILD TRAUMATIC BRAIN INJURY-INDUCED HETEROGENEITY THROUGH EVALUATION OF INDIVIDUAL DIFFERENCES

Journal of Neurotrauma

A NATIONAL BIOBANK AND DATABASE FOR PATIENTS WITH TRAUMATIC BRAIN INJURY (CANTBI)

Journal of Neurotrauma

MODERATE-SEVERE TRAUMATIC BRAIN INJURY ELICITS NEUROPATHOLOGICAL, BIOCHEMICAL, AND ELECTROPHYSIOLOGICAL CHANGES USING CHIMERA

Journal of Neurotrauma

INTERNATIONAL REGULATORY PATHWAYS FOR TBI BIOMARKER QUALIFICATION: PERSPECTIVES FROM THE INTBIR BIOMARKER WORKING GROUP

Journal of Neurotrauma

A PILOT STUDY FOR MEASURING MOTION OF THE IN VIVO BRAIN DURING HEAD IMPACTS USING CHIMERA

Journal of Neurotrauma

The pleiotropic vasoprotective functions of high density lipoproteins (HDL)

Journal of Biomedical Research

DOI: 10.7555/JBR.31.20160103

The Canadian Traumatic Brain Injury Research Consortium: Epitomizing Collaborative Research in Canada

Journal of Neurotrauma

DOI: 10.1089/NEU.2018.5871

Age at injury and genotype modify acute inflammatory and neurofilament-light responses to mild CHIMERA traumatic brain injury in wild-type and APP/PS1 mice

Experimental Neurology

DOI: 10.1016/J.EXPNEUROL.2017.12.007

A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers

ACS Chemical Neuroscience

DOI: 10.1021/ACSCHEMNEURO.7B00469

modCHIMERA: a novel murine closed-head model of moderate traumatic brain injury

Scientific Reports

DOI: 10.1038/S41598-018-25737-6

Ultracentrifugation and Depletion Methods of High-density Lipoprotein Isolation Yield Particles That Are Functionally Distinct in Some of Their Vasoprotective Functions

Arteriosclerosis, Thrombosis, and Vascular Biology

DOI: 10.1161/ATVB.38.SUPPL_1.385

Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway

Journal of Lipid Research

DOI: 10.1194/JLR.M081851

Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

eLife

Jerome Robert and Emily B Button and Brian Yuen and Megan Gilmour and Kevin Kang and Arvin Bahrabadi and Sophie Stukas and Wenchen Zhao and Iva Kulic and Cheryl L Wellington

DOI: 10.7554/eLife.29595

10 / 2017

AGE HAS A GREATER INFLUENCE THAN AMYLOID BURDEN ON THE ACUTE RESPONSE TO MILD TRAUMATIC BRAIN INJURY IN MICE

Journal of Neurotrauma

High-density lipoproteins suppress A beta-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture

Molecular Neurodegeneration

DOI: 10.1186/S13024-017-0201-0

Defining the biomechanical and biological threshold of murine mild traumatic brain injury using CHIMERA (Closed Head Impact Model of Engineered Rotational Acceleration)

Experimental Neurology

DOI: 10.1016/J.EXPNEUROL.2017.03.003

High-Density Lipoproteins Suppress Amyloid Beta Induced Human Brain Microvascular Endothelial Cell Activation

Arteriosclerosis, Thrombosis, and Vascular Biology

DEFINING THE BIOMECHANICAL AND BIOLOGICAL THRESHOLD OF MURINE MILD TRAUMATIC BRAIN INJURY USING CHIMERA

Journal of Neurotrauma

Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12

Journal of Neurotrauma

DOI: 10.1089/NEU.2016.4813

Defining an Analytic Framework to Evaluate Quantitative MRI Markers of Traumatic Axonal Injury: Preliminary Results in a Mouse Closed Head Injury Model

eNeuro

DOI: 10.1523/ENEURO.0164-17.2017

NEUROPATHOLOGY IN APP/PS1 MICE IS EXACERBATED AFTER CHIMERA (CLOSED-HEAD IMPACT MODEL OF ENGINEERED ROTATIONAL ACCELERATION)-INDUCED TRAUMATIC BRAIN INJURY

Journal of Cerebral Blood Flow & Metabolism

Reconstituted high-density lipoproteins acutely reduce soluble brain A levels in symptomatic APP/PS1 mice

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI: 10.1016/J.BBADIS.2015.10.005

LINEAR HEAD KINEMATICS PREDICTS DURATION OF UNCONSCIOUSNESS AND SEVERITY OF AXONAL INJURY IN THE CHIMERA MOUSE MODEL OF CONCUSSION

Journal of Neurotrauma

Chronic Exposure to Androgenic-Anabolic Steroids Exacerbates Axonal Injury and Microgliosis in the CHIMERA Mouse Model of Repetitive Concussion

Plos One

DOI: 10.1371/JOURNAL.PONE.0146540

Relation between plasma and brain lipids

Current Opinion in Lipidology

DOI: 10.1097/MOL.0000000000000291

DTI ABNORMALITIES IN THE CLOSED HEAD INJURY MODEL OF ENGINEERED ROTATIONAL ACCELERATION (CHIMERA) MOUSE MODEL

Journal of Neurotrauma

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

Plos One

DOI: 10.1371/JOURNAL.PONE.0162384

Distinct roles for metalloproteinases during traumatic brain injury

Neurochemistry International

DOI: 10.1016/J.NEUINT.2016.02.013

CHIMERA MILD TRAUMATIC BRAIN INJURY RESULTS IN COGNITIVE DYSFUNCTION UP TO 8-MONTHS POST INJURY IN THE APP/PS1 TRANSGENIC MOUSE

Journal of Neurotrauma

BIOMECHANICAL AND FUNCTIONAL CHARACTERIZATION OF CHIMERA IN AN APP/PS1 MODEL OF ALZHEIMER'S DISEASE

Journal of Neurotrauma

High-density lipoproteins at the interface between central nervous system and plasma lipoprotein metabolism

Clinical Lipidology

DOI: 10.2217/CLP.14.64

EXPOSURE TO ANABOLIC ANDROGENIC STEROIDS DOES NOT EXACERBATE ACUTE POST-INJURY OUTCOMES IN MICE SUBJECTED TO REPETITIVE CONCUSSION

Journal of Neurotrauma

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

DOI: 10.1016/J.JALZ.2014.10.008

NEUROPATHOLOGICAL AND BIOCHEMICAL ASSESSMENT OF CHIMERA: A NOVEL CLOSED-HEAD IMPACT MODEL OF ENGINEERED ROTATIONAL ACCELERATION

Journal of Neurotrauma

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer's Disease

Cell Metabolism

DOI: 10.1016/J.CMET.2014.01.003

ApoE secretion modulating bromotyrosine derivative from the Australian marine sponge Callyspongia sp

Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/J.BMCL.2014.05.054

Intravenously Injected Human Apolipoprotein A-I Rapidly Enters the Central Nervous System via the Choroid Plexus

Journal of the American Heart Association

DOI: 10.1161/JAHA.114.001156

BIOMECHANICAL AND FUNCTIONAL CHARACTERIZATION OF CHIMERA: A NOVEL CLOSED-HEAD IMPACT MODEL OF ENGINEERED ROTATIONAL ACCELERATION

Journal of Neurotrauma

Intravenously Injected Human Apolipoprotein A-I Rapidly Enters the Central Nervous System via the Choroid Plexus in Mice

Arteriosclerosis, Thrombosis, and Vascular Biology

HDL and cholesterol handling in the brain

Cardiovascular Research

DOI: 10.1093/CVR/CVU148

Development of an Engineered Base Cerebrovasculature Model to Study Alzheimer's Disease in vitro

Arteriosclerosis, Thrombosis, and Vascular Biology

Aplysinellamides A-C, Bromotyrosine-Derived Metabolites from an Australian Aplysinella sp Marine Sponge

Journal of Natural Products

DOI: 10.1021/NP500119E

Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury

Molecular Neurodegeneration

DOI: 10.1186/1750-1326-9-55

LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice

Journal of Lipid Research

DOI: 10.1194/JLR.M049940

Hormonal modulators of glial ABCA1 and apoE levels

Journal of Lipid Research

DOI: 10.1194/JLR.M042473

LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function

Journal of Lipid Research

DOI: 10.1194/JLR.M030080

ABCA1 influences neuroinflammation and neuronal death

Neurobiology of Disease

DOI: 10.1016/J.NBD.2013.01.018

Towards clinical management of traumatic brain injury: a review of models and mechanisms from a biomechanical perspective

Disease Models & Mechanisms

DOI: 10.1242/DMM.011320

The Liver X Receptor Agonist GW3965 Improves Recovery from Mild Repetitive Traumatic Brain Injury in Mice Partly through Apolipoprotein E

Plos One

DOI: 10.1371/JOURNAL.PONE.0053529

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired -Cell Function

Diabetes

DOI: 10.2337/DB11-1341

The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI: 10.1016/J.BBALIP.2011.08.014

An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia

Journal of Lipid Research

DOI: 10.1194/JLR.M014365

ApoE and cholesterol in schizophrenia and bipolar disorder: comparison of grey and white matter and relation with APOE genotype

Journal of Psychiatry & Neuroscience

DOI: 10.1503/JPN.090116

ABCA1, apoE and apoA-I as potential therapeutic targets for treating Alzheimer's disease

Neurodegenerative Disease Management

DOI: 10.2217/NMT.11.23

Probucol Reduces Enterocytic Amyloid-beta Relative to Chylomicron Apolipoprotein B in Mice Chronically Fed Saturated Fats

Atherosclerosis Supplements

DOI: 10.1016/J.ATHEROSCLEROSISSUP.2010.04.036

Cholesterol Defect Is Marked across Multiple Rodent Models of Huntington's Disease and Is Manifest in Astrocytes

The Journal of Neuroscience

DOI: 10.1523/JNEUROSCI.0917-10.2010

Serum lipids and gender affect trajectories of cognitive function in late life

Clinical Lipidology

DOI: 10.2217/CLP.10.46

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

Journal of Biological Chemistry

DOI: 10.1074/JBC.M110.108100

Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta

British Journal of Nutrition

DOI: 10.1017/S0007114509992194

Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function

The Journal of Neuroscience

DOI: 10.1523/JNEUROSCI.4741-08.2009

Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1

Lipids in Health and Disease

DOI: 10.1186/1476-511X-8-5

Why lipids are important for Alzheimer disease?

Molecular and Cellular Biochemistry

DOI: 10.1007/S11010-008-0012-2

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins

Journal of Lipid Research

DOI: 10.1194/JLR.M800584-JLR200

Greasing the wheels of A beta clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E

BioFactors

DOI: 10.1002/BIOF.37

Three-dimensional colocalization analysis of plasma-derived apolipoprotein B with amyloid plaques in APP/PS1 transgenic mice

Histochemistry and Cell Biology

DOI: 10.1007/S00418-009-0567-3

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

Journal of Lipid Research

DOI: 10.1194/JLR.M700481-JLR200

Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

DOI: 10.1161/ATVBAHA.108.168542

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

Journal of Clinical Investigation

DOI: 10.1172/JCI33622

Cholesterol metabolism, apolipoprotein E, adenosine triphosphate-binding cassette transporters, and Alzheimer's disease

Current Opinion in Lipidology

DOI: 10.1097/MOL.0B013E32813AEABF

MEDI 289-Multifunctional proligands for Alzheimer's disease therapy

Abstracts of Papers of the American Chemical Society

The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein

Journal of Lipid Research

DOI: 10.1194/JLR.M600542-JLR200

Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo

Journal of Lipid Research

DOI: 10.1194/JLR.M600543-JLR200

Wild-type huntingtin protects neurons from excitotoxicity

Journal of Neurochemistry

DOI: 10.1111/J.1471-4159.2005.03605.X

Mutant Huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH

Proceedings of the National Academy of Sciences

DOI: 10.1073/PNAS.0511316103

Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A in plasma

Neurobiology of Disease

DOI: 10.1016/J.NBD.2006.06.007

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux

Journal of Biological Chemistry

DOI: 10.1074/JBC.M601019200

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease

Journal of Biological Chemistry

DOI: 10.1074/JBC.M508781200

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

Cell Death and Differentiation

DOI: 10.1038/SJ.CDD.4401358

The contribution of hepatic adenosine triphosphate-binding cassette transporter, ABCA1, to high-density lipoprotein cholesterol levels in vivo

Journal of Investigative Medicine

DOI: 10.1097/00042871-200401001-00416

Inhibition of calpain cleavage of huntingtin reduces toxicity - Accumulation of calpain/caspase fragments in the nucleus

Journal of Biological Chemistry

DOI: 10.1074/JBC.M401267200

Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism

Clinical Genetics

DOI: 10.1111/J.0009-9163.2004.00280.X

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility

Journal of Lipid Research

DOI: 10.1194/JLR.M400007-JLR200

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

Molecular and Cellular Neuroscience

DOI: 10.1016/J.MCN.2003.11.014

Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain

Journal of Biological Chemistry

DOI: 10.1074/JBC.M407962200

Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1

Journal of Lipid Research

DOI: 10.1194/JLR.M300110-JLR200

Huntingtin proteolysis in Huntington disease

Clinical Neuroscience Research

DOI: 10.1016/S1566-2772(03)00055-0

Huntington's disease - Preface

Clinical Neuroscience Research

DOI: 10.1016/S1566-2772(03)00053-7

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

The American Journal of Human Genetics

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

Journal of Biological Chemistry

DOI: 10.1074/JBC.M211224200

A spectrum of neurological phenotypes caused by mutations in the X-linked aristaless-related homeobox gene, ARX

Clinical Genetics

DOI: 10.1034/J.1399-0004.2003.00061.X

Pro-survival effects of wild-type huntingtin in vivo

The American Journal of Human Genetics

Defective regulation of extracellular ion homeostasis causes peripheral neuropathy associated with agenesis of the corpus callosum

Clinical Genetics

DOI: 10.1034/J.1399-0004.2003.T01-1-00061.X

ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens

Journal of Biological Chemistry

DOI: 10.1074/JBC.M212377200

PKA site-specific phosphorylation of ABCA1 regulates ApoA-1-dependent phospholipid efflux

Circulation

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease

The Journal of Neuroscience

DOI: 10.1523/JNEUROSCI.22-18-07862.2002

ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

Laboratory Investigation

DOI: 10.1038/LABINVEST.3780421

Nuclear localization of a truncation product of mutant atrophin-1, increases cellular toxicity

Molecular Biology of the Cell

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

Human Molecular Genetics

DOI: 10.1093/HMG/11.23.2815

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

Neuron

DOI: 10.1016/S0896-6273(02)00615-3

Protein kinase a site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux

Journal of Biological Chemistry

DOI: 10.1074/JBC.M204923200

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

Journal of Lipid Research

DOI: 10.1194/JLR.M200277-JLR200

Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and apoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1

Journal of Biological Chemistry

DOI: 10.1074/JBC.M102503200

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

Proceedings of the National Academy of Sciences

DOI: 10.1073/PNAS.041566798

Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death

Proceedings of the National Academy of Sciences

DOI: 10.1073/PNAS.231476398

Mutant huntingtin enhances excitotoxic cell death

Molecular and Cellular Neuroscience

DOI: 10.1006/MCNE.2000.0909

Increased HDL-C and apoA1 dependent efflux modulated by LXREs in human ABCA1 BAC transgenic mice

Circulation

Truncation mutations in human ABCA1 suppress normal upregulation of wild-type ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

Circulation

Huntington disease: new insights on the role of huntingtin cleavage

Journal of Neural Transmission, Supplement

DOI: 10.1007/978-3-7091-6284-2_1

The road less traveled: functional recovery from neurodegeneration

Clinical Genetics

DOI: 10.1034/J.1399-0004.2000.580302.1.X

Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches

Clinical Genetics

DOI: 10.1034/J.1399-0004.2000.570101.X

Recent insights into the molecular pathogenesis of Huntington disease (vol 19, pg 385, 1999)

Seminars in Neurology

Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain

Journal of Biological Chemistry

DOI: 10.1074/JBC.M008408200

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

Journal of Biological Chemistry

DOI: 10.1074/JBC.M001475200

Recent insights into the molecular pathogenesis of Huntington disease

Seminars in Neurology

DOI: 10.1055/S-2008-1040853

Disturbed interaction between Huntingtin and HIP3 implicates defects in neuronal endocytosis in the pathogenesis of HD

The American Journal of Human Genetics

Insufficient death: autoimmune lymphoproliferative syndrome

Clinical Genetics

DOI: 10.1034/J.1399-0004.1999.560202.X

Subtype-specific enhancement of NMDA receptor currents by mutant Huntingtin

Journal of Neurochemistry

DOI: 10.1046/J.1471-4159.1999.0721890.X

Kennedy's disease: Caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

Journal of Neurochemistry

DOI: 10.1046/J.1471-4159.1999.0720185.X

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

Journal of Biological Chemistry

DOI: 10.1074/JBC.274.13.8730

Inhibition of caspase cleavage of huntingtin protects neurons from toxicity and aggregate formation

The American Journal of Human Genetics

Quiescence versus apoptosis: Myc abundance determines pathway of exit from the cell cycle

Oncogene

DOI: 10.1038/SJ.ONC.1202241

An unexpected cause for combined deficiency of coagulation factors V and VIII

Clinical Genetics

The influence of Huntingtin protein size on nuclear localization and cellular toxicity

The Journal of Cell Biology

DOI: 10.1083/JCB.141.5.1097

New insights into the genetics of lissencephaly

Clinical Genetics

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

Journal of Biological Chemistry

DOI: 10.1074/JBC.273.15.9158

Spinal muscular atrophy: a disease of altered RNA metabolism?

Clinical Genetics

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

Nature Genetics

DOI: 10.1038/NG0298-150

The fatal attraction of polyglutamine-containing proteins

Clinical Genetics

DOI: 10.1111/J.1399-0004.1998.TB02687.X

HIP1, a human homologue of S-cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain

Nature Genetics

DOI: 10.1038/NG0597-44

Toward understanding the molecular pathology of Huntington's Disease

Brain Pathology

DOI: 10.1111/J.1750-3639.1997.TB00897.X

Development of an in vitro model for Huntington's disease: Evidence that the N-terminal domain of huntingtin is toxic to cells

The American Journal of Human Genetics

Caspase cleavage of huntingtin, atrophin-1 and androgen receptor

The American Journal of Human Genetics

The transition from growth to quiescence versus apoptosis in serum-starved cells is decided by c-Myc but not by cdk2

Molecular Biology of the Cell

Of molecular interactions, mice and mechanisms: new insights into Huntington's disease

Current Opinion in Neurology

DOI: 10.1097/00019052-199708000-00003

C-myc overexpression in a tetracycline-based eukaryotic expression system affects cyclin-dependent kinase activity during apoptosis

Molecular Biology of the Cell

Analysis of c-fos mRNA degradation in a tetracycline-regulated system

Molecular Biology of the Cell

MULTIPLE ELEMENTS IN THE C-FOS PROTEIN-CODING REGION FACILITATE MESSENGER-RNA DEADENYLATION AND DECAY BY A MECHANISM COUPLED TO TRANSLATION

Journal of Biological Chemistry

THE DESTABILIZING ELEMENTS IN THE CODING REGION OF C-FOS MESSENGER-RNA ARE RECOGNIZED AS RNA

Molecular and Cellular Biology

DOI: 10.1128/MCB.13.8.5034

PHOTOSYNTHESIS GENE SUPEROPERONS IN PURPLE NONSULFUR BACTERIA - THE TIP OF THE ICEBERG

Canadian Journal of Microbiology

DOI: 10.1139/M92-003

FUNCTIONAL-SIGNIFICANCE OF OVERLAPPING TRANSCRIPTS OF CRTEF, BCHCA, AND PUF PHOTOSYNTHESIS GENE OPERONS IN RHODOBACTER-CAPSULATUS

Journal of Bacteriology

DOI: 10.1128/JB.173.9.2954-2961.1991

OVERLAPPING MESSENGER-RNA TRANSCRIPTS OF PHOTOSYNTHESIS GENE OPERONS IN RHODOBACTER-CAPSULATUS

Journal of Bacteriology

DOI: 10.1128/JB.173.4.1432-1443.1991

LOCALIZATION OF THE RHODOBACTER-CAPSULATUS BCHCA OPERON OXYGEN-REGULATED PROMOTER

CURRENT RESEARCH IN PHOTOSYNTHESIS, VOLS 1-4

STRUCTURAL-ANALYSIS OF THE RHODOBACTER-CAPSULATUS BCHC BACTERIOCHLOROPHYLL BIOSYNTHESIS GENE

Molecular Biology of Membrane-bound Complexes in Phototrophic Bacteria

PROMOTER MAPPING AND NUCLEOTIDE-SEQUENCE OF THE BCHC BACTERIOCHLOROPHYLL BIOSYNTHESIS GENE FROM RHODOBACTER-CAPSULATUS

Gene

DOI: 10.1016/0378-1119(89)90111-X

Current Projects

ABCA1 is a cholesterol transporter that is widely expressed throughout the body. Outside the central nervous system, ABCA1 functions in the biogenesis of high-density lipoprotein (HDL), where it mediates the efflux of cholesterol and phospholipids to apolipoprotein (apo) A-I. Deficiency of ABCA1 results in lack of circulating HDL and greatly reduced levels of apoA-I. ABCA1 is also expressed in cells of the central nervous system, but its roles in brain lipid metabolism are not yet fully understood. In the brain, glia synthesize the apolipoproteins involved in central nervous system lipid metabolism. We have recently demonstrated that glial ABCA1 is required for cholesterol efflux to apoA-I and plays a key role in facilitating cholesterol efflux to apoE, which is the major apolipoprotein in the brain and a well-established risk factor for Alzheimer's disease. In both astrocytes and microglia, ABCA1 deficiency reduces lipid efflux to exogenous apoE. The impaired ability to efflux lipids in ABCA1-/- glia results in lipid accumulation in both astrocytes and microglia under normal culture conditions. Additionally, apoE secretion is compromised in ABCA1-/- astrocytes and microglia. In vivo, deficiency of ABCA1 results in a 65% decrease in apoE levels in whole brain, and a 75-80% decrease in apoE levels in hippocampus and striatum. Additionally, the effect of ABCA1 on apoE is selective, as apoJ levels are unchanged in brains ABCA1-/- mice. Taken together, these results show that glial ABCA1 is a key influence in apoE metabolism in the brain, and may affect the pathogenesis of Alzheimer's disease. We are currently testing whether deficiency or overexpression of ABCA1 affects Alzheimer's disease in vivo.

Down syndrome (DS) is a very common genetic disorder caused by inheritance of an extra copy of chromosome 21, which results in mental disability, heart defects, hearing loss, obesity, diabetes, cholesterol gallstones, and Alzheimer's disease. DS affects approximately 1 in 1000 births, and is a major concern for older mothers. One of the biggest challenges researchers face is to understand how an extra copy of genes on chromosome 21 causes DS. A significant breakthrough was the completion of the DNA sequence of chromosome 21 and the identification of 225 known or predicted genes. One candidate gene that resides on chromosome 21 is the cholesterol transporter ABCG1. ABCG1 regulates cholesterol trafficking and may therefore affect several problems associated with DS including dyslipidemia, cholesterol gallstone formation, and Alzheimer's disease, all of which are connected to cholesterol metabolism. We hypothesize that inheritance of an extra copy of ABCG1 may explain some of the features observed in patients with DS. To test this hypothesis, we have generated mice that specifically express an extra copy of human ABCG1. Importantly, we have designed these mice to mimic as closely as possible how ABCG1 would be overproduced in DS patients. The overall objective of this project is to characterize the impact of selective ABCG1 overexpression on lipid metabolism of these mice, particularly with respect to Alzheimer's disease, atherosclerosis, and cholesterol gallstone formation.

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Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Cheryl Wellington

PhD, BSc

Affiliate Investigator, BC Children's Hospital

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Pharmacological inhibition of O-GlcNAcase reduces pS129-a-synuclein positive aggregates in the substantia nigra of mThy1-hSNCA mice

Age dictates brain functional connectivity and axonal integrity following repetitive mild traumatic brain injuries in mice

Age dictates brain functional connectivity and axonal integrity following repetitive mild traumatic brain injuries

Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia

Solving neurodegeneration: common mechanisms and strategies for new treatments

PDMS Organ-On-Chip Design and Fabrication: Strategies for Improving Fluidic Integration and Chip Robustness of Rapidly Prototyped Microfluidic In Vitro Models

Neurologic Prognostication After Cardiac Arrest Using Brain Biomarkers A Systematic Review and Meta-analysis

Prognostic peripheral blood biomarkers at ICU admission predict COVID-19 clinical outcomes

Diffusely abnormal white matter in clinically isolated syndrome is associated with parenchymal loss and elevated neurofilament levels

Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway (vol 59, pg 830, 2018)

Serum neurofilament light chain correlates with myelin and axonal magnetic resonance imaging markers in multiple sclerosis

Persistently elevated complement alternative pathway biomarkers in COVID-19 correlate with hypoxemia and predict in-hospital mortality

Blood Biomarkers of Brain Injury in Women who Have Experienced Intimate Partner Violence: A Pilot Study

Altered tau in rTg4510 mice after a single interfaced CHIMERA traumatic brain injury

Blood-based traumatic brain injury biomarkers - Clinical utilities and regulatory pathways in the United States, Europe and Canada

Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes

Review of Design Considerations for Brain-on-a-Chip Models

Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol

CHIMERA TRAUMATIC BRAIN INJURY IN A MOUSE MODEL OF TAUOPATHY

Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest

Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

Characterization of Cerebrospinal Fluid Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) as a Biomarker of Human Acute Traumatic Spinal Cord Injury

Development of a novel, sensitive translational immunoassay to detect plasma glial fibrillary acidic protein (GFAP) after murine traumatic brain injury

Assessing the importance of interleukin-6 in COVID-19

Correlations of Serum Neurofilaments with Myelin, Axonal and Volumetric Imaging Across the Multiple Sclerosis Spectrum

Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

Amelioration of COVID-19-related cytokine storm syndrome: parallels to chimeric antigen receptor-T cell cytokine release syndrome

Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop

An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases

The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19

Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E

An Automated Kinematic Measurement System for Sagittal Plane Murine Head Impacts

Alternatives to amyloid for Alzheimer's disease therapies-a symposium report

Axl receptor tyrosine kinase is a regulator of apolipoprotein E

Increased severity of the CHIMERA model induces acute vascular injury, sub-acute deficits in memory recall, and chronic white matter gliosis

Technique and preliminary findings for in vivo quantification of brain motion during injurious head impacts

A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease

Primum non nocere: a call for balance when reporting on CTE

CHIMERA REPETITIVE MILD TBI INDUCES PTSD-LIKE BEHAVIOR AND CHRONIC NEUROPATHOLOGIES IN WILD-TYPE AND APP/ PS1 MICE

An End-to-end System for Automatic Characterization of Iba1 Immunopositive Microglia in Whole Slide Imaging

HDL from an Alzheimer's disease perspective

CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice

CHARACTERIZATION OF SERUM TOTAL TAU FOLLOWING PEDIATRIC TRAUMATIC BRAIN INJURY

Vascular dysfunction-The disregarded partner of Alzheimer's disease

MODERATE CHIMERA INJURY ELICITS DIFFERENTIAL ACUTE INFLAMMATORY RESPONSES IN HUMANIZED APOE3 AND APOE4 TARGETED-REPLACEMENT MICE

Vasoprotective Functions of High-Density Lipoproteins Relevant to Alzheimer's Disease Are Partially Conserved in Apolipoprotein B-Depleted Plasma

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

Repetitive closed-head impact model of engineered rotational acceleration (CHIMERA) injury in rats increases impulsivity, decreases dopaminergic innervation in the olfactory tubercle and generates white matter inflammation, tau phosphorylation and degeneration

Characterisation of serum total tau following paediatric traumatic brain injury: a case-control study

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

Cerebral Microvascular Injury: A Potentially Treatable Endophenotype of Traumatic Brain Injury-Induced Neurodegeneration

AN AUTOMATED KINEMATIC MEASUREMENT SYSTEM FOR USE WITH THE CHIMERA MURINE MODEL OF TRAUMATIC BRAIN INJURY

SERUM TOTAL TAU AS A DIAGNOSTIC AND PROGNOSTIC MARKER IN PEDIATRIC TRAUMATIC BRAIN INJURY

Military-related risk factors for dementia

ADDRESSING MILD TRAUMATIC BRAIN INJURY-INDUCED HETEROGENEITY THROUGH EVALUATION OF INDIVIDUAL DIFFERENCES

A NATIONAL BIOBANK AND DATABASE FOR PATIENTS WITH TRAUMATIC BRAIN INJURY (CANTBI)

MODERATE-SEVERE TRAUMATIC BRAIN INJURY ELICITS NEUROPATHOLOGICAL, BIOCHEMICAL, AND ELECTROPHYSIOLOGICAL CHANGES USING CHIMERA

INTERNATIONAL REGULATORY PATHWAYS FOR TBI BIOMARKER QUALIFICATION: PERSPECTIVES FROM THE INTBIR BIOMARKER WORKING GROUP

A PILOT STUDY FOR MEASURING MOTION OF THE IN VIVO BRAIN DURING HEAD IMPACTS USING CHIMERA

The pleiotropic vasoprotective functions of high density lipoproteins (HDL)

The Canadian Traumatic Brain Injury Research Consortium: Epitomizing Collaborative Research in Canada

Age at injury and genotype modify acute inflammatory and neurofilament-light responses to mild CHIMERA traumatic brain injury in wild-type and APP/PS1 mice

A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers

modCHIMERA: a novel murine closed-head model of moderate traumatic brain injury

Ultracentrifugation and Depletion Methods of High-density Lipoprotein Isolation Yield Particles That Are Functionally Distinct in Some of Their Vasoprotective Functions

Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway

Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

AGE HAS A GREATER INFLUENCE THAN AMYLOID BURDEN ON THE ACUTE RESPONSE TO MILD TRAUMATIC BRAIN INJURY IN MICE

High-density lipoproteins suppress A beta-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture

Defining the biomechanical and biological threshold of murine mild traumatic brain injury using CHIMERA (Closed Head Impact Model of Engineered Rotational Acceleration)

High-Density Lipoproteins Suppress Amyloid Beta Induced Human Brain Microvascular Endothelial Cell Activation