Overview

Dr. Goldfarb’s current research focuses primarily on novel diagnostic,management and prevention strategies for pediatric infectious disease in resource limited settings.

Publications

Characterizing Longitudinal Antibody Responses in Recovered Individuals Following COVID-19 Infection and Single-Dose Vaccination: A Prospective Cohort Study
Viruses
Andrea Olmstead and Aidan M. Nikiforuk and Sydney Schwartz and Ana Citlali Márquez and Tahereh Valadbeigy and Eri Flores and Monika Saran and David M. Goldfarb and Althea Hayden and Shazia Masud and Shannon L. Russell and Natalie Prystajecky and Agatha N. Jassem and Muhammad Morshed and Inna Sekirov
DOI: 10.3390/v14112416
10/2022

Evaluation of observed and unobserved self-collection of saline gargle samples for the detection of SARS-CoV-2 in outpatients
Diagnostic Microbiology and Infectious Disease
Kinshella, M.-L.W. and Tilley, P. and Al-Rawahi, G.N. and Srigley, J.A. and Kayda, I. and Canes, M. and McLennan, M. and Bone, J.N. and Dittrick, M. and Gadkar, V.J. and Hoang, L.M.N. and Goldfarb, D.M.
DOI: 10.1016/j.diagmicrobio.2021.115566
2022

Characterizing the bioburden of ESBL-producing organisms in a neonatal unit using chromogenic culture media: a feasible and efficient environmental sampling method
Antimicrobial Resistance and Infection Control
Vurayai, M. and Strysko, J. and Kgomanyane, K. and Bayani, O. and Mokomane, M. and Machiya, T. and Arscott-Mills, T. and Goldfarb, D.M. and Steenhoff, A.P. and McGann, C. and Nakstad, B. and Gezmu, A. and Richard-Greenblatt, M. and Coffin, S.
DOI: 10.1186/s13756-021-01042-2
2022

Evaluation of the Performance of a Multiplexed Serological Assay in the Detection of SARS-CoV-2 Infections in a Predominantly Vaccinated Population
Microbiology Spectrum
Asamoah-Boaheng, M. and Goldfarb, D.M. and Barakauskas, V. and Kirkham, T.L. and Demers, P.A. and Ehsanul Karim, M. and Lavoie, P.M. and Marquez, A.C. and Jassem, A.N. and Jenneson, S. and MacDonald, C. and Grunau, B.
DOI: 10.1128/spectrum.01454-21
2022

Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals
JAMA - Journal of the American Medical Association
Grunau, B. and Goldfarb, D.M. and Asamoah-Boaheng, M. and Golding, L. and Kirkham, T.L. and Demers, P.A. and Lavoie, P.M.
DOI: 10.1001/jama.2021.21921
2022

Determining the optimal SARS-CoV-2 mRNA vaccine dosing interval for maximum immunogenicity
bioRxiv
Asamoah-Boaheng, M. and Goldfarb, D.M. and Prusinkiewicz, M.A. and Golding, L. and Karim, M.E. and Barakauskas, V. and Wall, N. and Jassem, A.N. and Marquez, A.C. and MacDonald, C. and O'Brien, S.F. and Lavoie, P. and Grunau, B.
DOI: 10.1101/2022.03.01.482592
2022

Healthcare worker perspectives on mother’s insufficient milk supply in Malawi
International Breastfeeding Journal
Piccolo, O. and Kinshella, M.-L.W. and Salimu, S. and Vidler, M. and Banda, M. and Dube, Q. and Kawaza, K. and Goldfarb, D.M. and Nyondo-Mipando, A.L.
DOI: 10.1186/s13006-022-00460-1
2022

Optimising the management of childhood acute diarrhoeal disease using a rapid test-and- treat strategy and/or Lactobacillus reuteri DSM 17938: A multicentre, randomised, controlled, factorial trial in Botswana
BMJ Global Health
Pernica, J.M. and Arscott-Mills, T. and Steenhoff, A.P. and Mokomane, M. and Moorad, B. and Bapabi, M. and Lechiile, K. and Mangwegape, O. and Batisani, B. and Mawoko, N. and Muthoga, C. and Vanniyasingam, T. and Ewusie, J. and Lowe, A. and Bonsu, J.M. and Gezmu, A.M. and Smieja, M. and Mazhani, L. and Stordal, K. and Thabane, L. and Kelly, M.S. and Goldfarb, D.M.
DOI: 10.1136/bmjgh-2021-007826
2022

Performance of Immunoglobulin G Serology on Finger Prick Capillary Dried Blood Spot Samples to Detect a SARS-CoV-2 Antibody Response
Microbiology Spectrum
Nikiforuk, A.M. and McMillan, B. and Bartlett, S.R. and Márquez, A.C. and Pidduck, T. and Kustra, J. and Goldfarb, D.M. and Barakauskas, V. and Sinclair, G. and Patrick, D.M. and Sadarangani, M. and Ogilvie, G.S. and Krajden, M. and Morshed, M. and Sekirov, I. and Jassem, A.N.
DOI: 10.1128/spectrum.01405-21
2022

Comparative 6-Month Wild-Type and Delta-Variant Antibody Levels and Surrogate Neutralization for Adults Vaccinated with BNT162b2 versus mRNA-1273
Microbiology Spectrum
Grunau, B. and Golding, L. and Prusinkiewicz, M.A. and Asamoah-Boaheng, M. and Armour, R. and Marquez, A.C. and Jassem, A.N. and Barakauskas, V. and O?Brien, S.F. and Drews, S.J. and Haig, S. and Lavoie, P.M. and Goldfarb, D.M.
DOI: 10.1128/spectrum.02702-21
2022

SARS-CoV-2 seroprevalence among Vancouver public school staff in British Columbia, Canada: A cross-sectional study
BMJ Open
Goldfarb, D.M. and Mâsse, L.C. and Watts, A.W. and Hutchison, S.M. and Muttucomaroe, L. and Bosman, E.S. and Barakauskas, V.E. and Choi, A. and Dhillon, N. and Irvine, M.A. and Reicherz, F. and O'Reilly, C. and Sediqi, S. and Xu, R.Y. and Razzaghian, H.R. and Sadarangani, M. and Coombs, D. and O'Brien, S.F. and Lavoie, P.M.
DOI: 10.1136/bmjopen-2021-057846
2022

Molecular characterization of sapovirus from children with gastroenteritis in Botswana
Journal of Clinical Virology Plus
Makhaola, K. and Lechiile, K. and Moyo, S. and Goldfarb, D.M. and Pernica, J.M. and Kebaabetswe, L.P.
DOI: 10.1016/j.jcvp.2022.100077
2022

Perceptions of expressed breast milk for preterm infants in Malawian hospitals: A qualitative study
Journal of Neonatal Nursing
Ong, A.-J. and Woo Kinshella, M.-L. and Salimu, S. and Vidler, M. and Elango, R. and Banda, M. and Dube, Q. and Goldfarb, D. and Kawaza, K. and Nyondo-Mipando, A.L.
DOI: 10.1016/j.jnn.2021.08.006
2022

Climate Change and Enteric Infections in the Canadian Arctic: Do We Know What’s on the Horizon?
Gastrointestinal Disorders
Emma Finlayson-Trick and Bronwyn Barker and Selina Manji and Sherilee Harper and Cedric P. Yansouni and David M. Goldfarb
DOI: 10.3390/gidisord3030012
08/2021

Barriers and facilitators for early and exclusive breastfeeding in health facilities in Sub-Saharan Africa: a systematic review
Global Health Research and Policy
Kinshella, M.-L.W. and Prasad, S. and Hiwa, T. and Vidler, M. and Nyondo-Mipando, A.L. and Dube, Q. and Goldfarb, D. and Kawaza, K.
DOI: 10.1186/s41256-021-00206-2
2021

Self-collected saline gargle samples as an alternative to health care worker-collected nasopharyngeal swabs for COVID-19 diagnosis in outpatients
Journal of Clinical Microbiology
Goldfarb, D.M. and Tilley, P. and Al-Rawahi, G.N. and Srigley, J.A. and Ford, G. and Pedersen, H. and Pabbi, A. and Hannam-Clark, S. and Charles, M. and Dittrick, M. and Gadkar, V.J. and Pernica, J.M. and Hoanga, L.M.N.
DOI: 10.1128/JCM.02427-20
2021

Barriers and facilitators of facility-based kangaroo mother care in sub-Saharan Africa: a systematic review
BMC Pregnancy and Childbirth
Kinshella, M.-L.W. and Hiwa, T. and Pickerill, K. and Vidler, M. and Dube, Q. and Goldfarb, D. and Nyondo-Mipando, A.L. and Kawaza, K.
DOI: 10.1186/s12884-021-03646-3
2021

Intention to receive a COVID-19 vaccine: results from a population-based survey in Canada
BMC Public Health
Ogilvie, G.S. and Gordon, S. and Smith, L.W. and Albert, A. and Racey, C.S. and Booth, A. and Gottschlich, A. and Goldfarb, D. and Murray, M.C.M. and Galea, L.A.M. and Kaida, A. and Brotto, L.A. and Sadarangani, M.
DOI: 10.1186/s12889-021-11098-9
2021

Facility assessment and qualitative analysis of health worker perspectives on neonatal health in Malawi
BMC Research Notes
Kinshella, M.-L.W. and Nyondo-Mipando, A.L. and Dube, Q. and Goldfarb, D.M. and Kawaza, K.
DOI: 10.1186/s13104-021-05679-5
2021

“Like works of our hands are giving testimony!” A qualitative study on kangaroo mother care and health worker empowerment in southern Malawi
African Journal of Reproductive Health
Kinshella, M.-L.W. and Salimu, S. and Pickerill, K. and Vidler, M. and Banda, M. and Newberry, L. and Dube, Q. and Molyneux, E.M. and Goldfarb, D.M. and Kawaza, K. and Nyondo-Mipando, A.L.
DOI: 10.29063/ajrh2021/v25i3s.7
2021

Mothers’ quality of life delivering kangaroo mother care at Malawian hospitals: a qualitative study
Health and Quality of Life Outcomes
Nyondo-Mipando, A.L. and Kinshella, M.-L.W. and Hiwa, T. and Salimu, S. and Banda, M. and Vidler, M. and Molyneux, E. and Dube, Q. and Goldfarb, D.M. and Kawaza, K.
DOI: 10.1186/s12955-021-01823-8
2021

SARS-CoV-2 serology: Validation of high-throughput chemiluminescent immunoassay (CLIA) platforms and a field study in British Columbia
Journal of Clinical Virology
Sekirov, I. and Barakauskas, V.E. and Simons, J. and Cook, D. and Bates, B. and Burns, L. and Masud, S. and Charles, M. and McLennan, M. and Mak, A. and Chahil, N. and Vijh, R. and Hayden, A. and Goldfarb, D. and Levett, P.N. and Krajden, M. and Morshed, M.
DOI: 10.1016/j.jcv.2021.104914
2021

A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2
JCI Insight
Majdoubi, A. and Michalski, C. and O?Connell, S.E. and Dada, S. and Narpala, S. and Gelinas, J. and Mehta, D. and Cheung, C. and Winkler, D.F.H. and Basappa, M. and Liu, A.C. and Görges, M. and Barakauskas, V.E. and Irvine, M. and Mehalko, J. and Esposito, D. and Sekirov, I. and Jassem, A.N. and Goldfarb, D.M. and Pelech, S. and Douek, D.C. and McDermott, A.B. and Lavoie, P.M.
DOI: 10.1172/jci.insight.146316
2021

Development and validation of a new triplex real-time quantitative reverse Transcriptase-PCR assay for the clinical detection of SARS-CoV-2
Molecular and Cellular Probes
Gadkar, V.J. and Goldfarb, D.M. and Young, V. and Watson, N. and Al-Rawahi, G.N. and Srigley, J. and Tilley, P.
DOI: 10.1016/j.mcp.2021.101744
2021

Cephalohaematoma: Not always a benign bump
Journal of Paediatrics and Child Health
Hung, T.-Y. and Coates, E. and McAlpine, A. and Tam, J. and Goldfarb, D.M. and McDonald, P.J. and Zelman, M. and Halverson, M. and Seaton, C.
DOI: 10.1111/jpc.15769
2021

Single-centre, open-label, randomised, trial to compare rapid molecular point-of-care streptococcal testing to standard laboratory-based testing for the management of streptococcal pharyngitis in children: Study protocol
BMJ Open
Pernica, J.M. and Smaill, F. and Kam, A.J. and Bartholomew, A. and Doan, Q. and Smieja, M. and Khan, S. and Sung, M. and Thabane, L. and Goldfarb, D.M.
DOI: 10.1136/bmjopen-2020-047271
2021

Dried blood spot specimens for SARS-CoV-2 antibody testing: A multi-site, multi-assay comparison
PLoS ONE
Cholette, F. and Mesa, C. and Harris, A. and Ellis, H. and Cachero, K. and Lacap, P. and Galipeau, Y. and Langlois, M.-A. and Gingras, A.-C. and Yansouni, C.P. and Papenburg, J. and Cheng, M.P. and Chakraborty, P. and Stein, D.R. and Van Caeseele, P. and Bartlett, S. and Krajden, M. and Goldfarb, D. and McGeer, A. and Osiowy, C. and Hankins, C. and Mazer, B. and Drebot, M. and Kim, J.
DOI: 10.1371/journal.pone.0261003
2021

Familiar but neglected: identification of gaps and recommendations to close them on exclusive breastfeeding support in health facilities in Malawi
International Breastfeeding Journal
Nyondo-Mipando, A.L. and Kinshella, M.-L.W. and Salimu, S. and Chiwaya, B. and Chikoti, F. and Chirambo, L. and Mwaungulu, E. and Banda, M. and Newberry, L. and Hiwa, T. and Vidler, M. and Dube, Q. and Molyneux, E. and Mfutso-Bengo, J. and Goldfarb, D.M. and Kawaza, K.
DOI: 10.1186/s13006-021-00418-9
2021

Association of the CPT1A p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut
Frontiers in Pediatrics
Collins, S.A. and Edmunds, S. and Akearok, G.H. and Thompson, J.R. and Erickson, A.C. and Hildes-Ripstein, E. and Miners, A. and Somerville, M. and Goldfarb, D.M. and Rockman-Greenberg, C. and Arbour, L.
DOI: 10.3389/fped.2021.678553
2021

"So sometimes, it looks like it's a neglected ward": Health worker perspectives on implementing kangaroo mother care in southern Malawi.
PloS one
Kinshella MW and Salimu S and Chiwaya B and Chikoti F and Chirambo L and Mwaungulu E and Banda M and Newberry L and Njirammadzi J and Hiwa T and Vidler M and Molyneux EM and Dube Q and Nyondo-Mipando AL
DOI: 10.1371/journal.pone.0243770
PubMed: 33332395
12/2020

"It brought hope and peace in my heart:" Caregivers perceptions on kangaroo mother care services in Malawi.
BMC pediatrics
Nyondo-Mipando AL and Kinshella MW and Salimu S and Chiwaya B and Chikoti F and Chirambo L and Mwaungulu E and Banda M and Newberry L and Njirammadzi J and Hiwa T and Vidler M and Kawaza K
DOI: 10.1186/s12887-020-02443-9
PubMed: 33261568
12/2020

Is untargeted iron supplementation harmful when iron deficiency is not the major cause of anaemia? Study protocol for a double-blind, randomised controlled trial among non-pregnant Cambodian women.
BMJ open
Fischer JA and Pei LX and Goldfarb DM and Albert A and Elango R and Kroeun H and Karakochuk CD
DOI: 10.1136/bmjopen-2020-037232
PubMed: 32801202
08/2020

What Is the Role of Severe Acute Respiratory Syndrome Coronavirus 2 Polymerase Chain Reaction Testing in Discontinuation of Transmission-based Precautions for Coronavirus Disease 2019 Patients?
Clinical Infectious Diseases
Bahaa Abu Raya and David M Goldfarb and Manish Sadarangani
DOI: 10.1093/cid/ciaa671
05/2020

Multicenter clinical evaluation of the revogene strep a molecular assay for detection of streptococcus pyogenes from throat swab specimens
Journal of Clinical Microbiology
Banerjee, D. and Michael, J. and Schmitt, B. and Salimnia, H. and Mhaissen, N. and Goldfarb, D.M. and Lachance, P. and Faron, M.L. and Aufderheide, T. and Ledeboer, N. and Weissfeld, A. and Selvarangan, R.
DOI: 10.1128/JCM.01775-19
2020

Implementing saline gargle sample collection for covid-19 testing
British Columbia Medical Journal
McLennan, M. and Goldfarb, D. and Donoghue, M. and Hoang, L.
2020

Barriers and enablers of implementing bubble Continuous Positive Airway Pressure (CPAP): Perspectives of health professionals in Malawi
PLoS ONE
Nyondo-Mipando, A.L. and Kinshella, M.-L.W. and Bohne, C. and Suwedi-Kapesa, L.C. and Salimu, S. and Banda, M. and Newberry, L. and Njirammadzi, J. and Hiwa, T. and Chiwaya, B. and Chikoti, F. and Vidler, M. and Dube, Q. and Molyneux, E. and Mfutso-Bengo, J. and Goldfarb, D.M. and Kawaza, K. and Mijovic, H.
DOI: 10.1371/journal.pone.0228915
2020

Barriers and facilitators to implementing bubble CPAP to improve neonatal health in sub-Saharan Africa: A systematic review
Public Health Reviews
Kinshella, M.-L.W. and Walker, C.R. and Hiwa, T. and Vidler, M. and Nyondo-Mipando, A.L. and Dube, Q. and Goldfarb, D.M. and Kawaza, K.
DOI: 10.1186/s40985-020-00124-7
2020

Neonatal sepsis in low-income countries: epidemiology, diagnosis and prevention
Expert Review of Anti-Infective Therapy
Popescu, C.R. and Cavanagh, M.M.M. and Tembo, B. and Chiume, M. and Lufesi, N. and Goldfarb, D.M. and Kissoon, N. and Lavoie, P.M.
DOI: 10.1080/14787210.2020.1732818
2020

Assessing quality of newborn care at district facilities in Malawi
BMC Health Services Research
Kawaza, K. and Kinshella, M.-L.W. and Hiwa, T. and Njirammadzi, J. and Banda, M. and Vidler, M. and Newberry, L. and Nyondo-Mipando, A.L. and Dube, Q. and Molyneux, E. and Goldfarb, D.M.
DOI: 10.1186/s12913-020-5065-2
2020

Performance of the ALethia CMV assay for detection of cytomegalovirus by use of neonatal saliva swabs
Journal of Clinical Microbiology
Gantt, S. and Goldfarb, D.M. and Park, A. and Rawlinson, W. and Boppana, S.B. and Lazzarotto, T. and Mertz, L.M.
DOI: 10.1128/JCM.01951-19
2020

Health workers' views on factors affecting caregiver engagement with bubble CPAP
BMC Pediatrics
Salimu, S. and Kinshella, M.-L.W. and Vidler, M. and Banda, M. and Newberry, L. and Dube, Q. and Molyneux, E.M. and Goldfarb, D.M. and Kawaza, K. and Nyondo-Mipando, A.L.
DOI: 10.1186/s12887-020-02088-8
2020

Risk factors for cerebrospinal fluid shunt infections during an outbreak: a case–control study
Journal of Hospital Infection
McAlpine, A.K. and Sauve, L.J. and Collet, J.C. and Goldfarb, D.M. and Guest, E. and McDonald, P.J. and Zheng, A. and Srigley, J.A.
DOI: 10.1016/j.jhin.2019.12.012
2020

Antibody Reactivity against SARS-CoV-2 in Adults from the Vancouver Metropolitan Area, Canada
SSRN
Majdoubi, A. and O?Connell, S.E. and Michalski, C. and Dada, S. and Narparla, S. and Gelinas, J. and Mehta, D. and Cheung, C. and Basappa, M. and Görges, M. and Barakauska, V.E. and Goldfarb, D.M. and Douek, D.C. and McDermott, A.B. and Lavoie, P.M.
DOI: 10.2139/ssrn.3708321
2020

Evaluation of Anatomically Designed Flocked Rectal Swabs for Use with the BioFire FilmArray Gastrointestinal Panel for Detection of Enteric Pathogens in Children Admitted to Hospital with Severe Gastroenteritis.
Journal of clinical microbiology
DOI: 10.1128/jcm.00962-19
PubMed: 31511336
11/2019

Asymptomatic Pharyngeal Carriage of Kingella kingae Among Young Children in Vancouver, British Columbia, Canada.
The Pediatric infectious disease journal
Masud S and Greenman J and Mulpuri K and Hasan MR and Goldfarb DM and Tilley P and Gadkar VJ and Al-Rawahi GN
DOI: 10.1097/inf.0000000000002403
PubMed: 31335573
07/2019

Dermacoccus sp. isolated from a brain abscess in a 4-year-old child.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Ivaska L and Alyazidi R and Hoang L and Goldfarb DM
DOI: 10.1016/j.jiac.2019.05.033
PubMed: 31253474
06/2019

New Tools to Test Stool: Managing Travelers' Diarrhea in the Era of Molecular Diagnostics.
Infectious disease clinics of North America
Eckbo EJ and Yansouni CP and Pernica JM and Goldfarb DM
DOI: 10.1016/j.idc.2018.10.012
PubMed: 30712762
03/2019

Asymptomatic Pharyngeal Carriage of Kingella kingae among Young Children in Vancouver, British Columbia, Canada
Pediatric Infectious Disease Journal
Masud, S. and Greenman, J. and Mulpuri, K. and Hasan, M.R. and Goldfarb, D.M. and Tilley, P. and Gadkar, V.J. and Al-Rawahi, G.N.
DOI: 10.1097/INF.0000000000002403
2019

Evaluation of anatomically designed flocked rectal swabs for use with the BioFire FilmArray gastrointestinal panel for detection of enteric pathogens in children admitted to hospital with severe gastroenteritis
Journal of Clinical Microbiology
Walker, C.R. and Lechiile, K. and Mokomane, M. and Steenhoff, A.P. and Arscott-Mills, T. and Pernica, J.M. and Goldfarb, D.M.
DOI: 10.1128/JCM.00962-19
2019

Diversity of Rotavirus Strains Circulating in Botswana before and after introduction of the Monovalent Rotavirus Vaccine
Vaccine
Mokomane, M. and Esona, M.D. and Bowen, M.D. and Tate, J.E. and Steenhoff, A.P. and Lechiile, K. and Gaseitsiwe, S. and Seheri, L.M. and Magagula, N.B. and Weldegebriel, G. and Pernica, J.M. and Mwenda, J.M. and Kasvosve, I. and Parashar, U.D. and Goldfarb, D.M.
DOI: 10.1016/j.vaccine.2019.09.022
2019

The prevalence and clinical characteristics of pertussis-associated pneumonia among infants in Botswana
BMC Pediatrics
Abu-Raya, B. and Goldfarb, D.M. and Smieja, M. and Luinstra, K. and Richard-Greenblatt, M. and Steenhoff, A.P. and Feemster, K.A. and Arscott-Mills, T. and Cunningham, C.K. and Shah, S.S. and Patel, M.Z. and Kelly, M.S. and Sadarangani, M.
DOI: 10.1186/s12887-019-1820-0
2019

Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana.
The Pediatric infectious disease journal
Kelly MS and Surette MG and Smieja M and Rossi L and Luinstra K and Steenhoff AP and Goldfarb DM and Pernica JM and Arscott-Mills T and Boiditswe S and Mazhani T and Rawls JF and Seed PC
DOI: 10.1097/inf.0000000000002174
PubMed: 30153231
11/2018

Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
Stang AS and Trudeau M and Vanderkooi OG and Lee BE and Chui L and Pang XL and Allen V and Burnham CD and Goldfarb DM and MacDonald J and Parsons B and Petrich A and Pollari F and Tarr PI and Freedman SB
DOI: 10.1155/2018/2589826
PubMed: 30363711
09/2018

Genetic and epidemiological analysis of norovirus from children with gastroenteritis in Botswana, 2013-2015.
BMC infectious diseases
Makhaola K and Moyo S and Lechiile K and Goldfarb DM and Kebaabetswe LP
DOI: 10.1186/s12879-018-3157-y
PubMed: 29848303
05/2018

Recovery of cytomegalovirus DNA from newborn saliva samples by different methods.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Goshen O and Goldfarb DM and Book L and Tilley P and Gantt S
DOI: 10.1016/j.jcv.2018.05.001
PubMed: 29753934
05/2018

Real-time Detection and Monitoring of Loop Mediated Amplification (LAMP) Reaction Using Self-quenching and De-quenching Fluorogenic Probes.
Scientific reports
Gadkar VJ and Goldfarb DM and Gantt S and Tilley PAG
DOI: 10.1038/s41598-018-23930-1
PubMed: 29615801
04/2018

The global burden of paediatric and neonatal sepsis: a systematic review.
The Lancet. Respiratory medicine
Fleischmann-Struzek C and Goldfarb DM and Schlattmann P and Schlapbach LJ and Reinhart K and Kissoon N
DOI: 10.1016/s2213-2600(18)30063-8
PubMed: 29508706
03/2018

Evaluation of the Influence of Gastrointestinal Coinfections on Rotavirus Vaccine Effectiveness in Botswana
The Pediatric Infectious Disease Journal
Margaret Mokomane and Jacqueline E. Tate and Andrew P. Steenhoff and Mathew D. Esona and Michael D. Bowen and Kwana Lechiile and Jeffrey M. Pernica and Ishmael Kasvosve and Umesh D. Parashar and David M. Goldfarb
DOI: 10.1097/inf.0000000000001828
03/2018

'Finding Gory'-bringing home an unwanted aquatic traveler.
Paediatrics & Child Health
Mijovic H and Henkelman E and Goldfarb DM
DOI: 10.1093/pch/pxx213
PubMed: 30455577
02/2018

The global problem of childhood diarrhoeal diseases: emerging strategies in prevention and management.
Therapeutic advances in infectious disease
Mokomane M and Kasvosve I and de Melo E and Pernica JM and Goldfarb DM
DOI: 10.1177/2049936117744429
PubMed: 29344358
01/2018

Correction: Rapid enteric testing to permit targeted antimicrobial therapy, with and without Lactobacillus reuteri probiotics, for paediatric acute diarrhoeal disease in Botswana: A pilot, randomized, factorial, controlled trial.
PloS one
Pernica JM and Steenhoff AP and Mokomane M and Moorad B and Lechiile K and Smieja M and Mazhani L and Cheng J and Kelly MS and Loeb M and Stordal K and Goldfarb DM
DOI: 10.1371/journal.pone.0194957
PubMed: 29561910
2018

Phylogenetic analyses and antimicrobial resistance profiles of Campylobacter spp. from diarrhoeal patients and chickens in Botswana
PLoS ONE
De Vries, S.P.W. and Vurayai, M. and Holmes, M. and Gupta, S. and Bateman, M. and Goldfarb, D. and Maskell, D.J. and Matsheka, M.I. and Grant, A.J.
DOI: 10.1371/journal.pone.0194481
2018

In reference to should infants who fail their newborn hearing screen undergo cytomegalovirus testing?
Laryngoscope
Gantt, S. and Goldfarb, D.M. and Dionne, F. and Bulman, D. and Doutré, S.M.
DOI: 10.1002/lary.27032
2018

Evaluation of the Influence of Gastrointestinal Coinfections on Rotavirus Vaccine Effectiveness in Botswana
Pediatric Infectious Disease Journal
Mokomane, M. and Tate, J.E. and Steenhoff, A.P. and Esona, M.D. and Bowen, M.D. and Lechiile, K. and Pernica, J.M. and Kasvosve, I. and Parashar, U.D. and Goldfarb, D.M.
DOI: 10.1097/INF.0000000000001828
2018

The global burden of paediatric and neonatal sepsis: a systematic review
The Lancet Respiratory Medicine
Fleischmann-Struzek, C. and Goldfarb, D.M. and Schlattmann, P. and Schlapbach, L.J. and Reinhart, K. and Kissoon, N.
DOI: 10.1016/S2213-2600(18)30063-8
2018

Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana
The Pediatric infectious disease journal
Kelly, M.S. and Surette, M.G. and Smieja, M. and Rossi, L. and Luinstra, K. and Steenhoff, A.P. and Goldfarb, D.M. and Pernica, J.M. and Arscott-Mills, T. and Boiditswe, S. and Mazhani, T. and Rawls, J.F. and Cunningham, C.K. and Shah, S.S. and Feemster, K.A. and Seed, P.C.
DOI: 10.1097/INF.0000000000002174
2018

Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana
Open Forum Infectious Diseases
Matthew Kelly and Michael Surette and Marek Smieja and Laura Rossi and Kathy Luinstra and Andrew Steenhoff and David Goldfarb and Tonya Arscott-Mills and Sefelani Boiditswe and Ikanyeng Rulaganyang and Charles Muthoga and Kwana Lechiile and Tiny Mazhani and John Rawls and Coleen Cunningham and Samir Shah and Kristen Feemster and Patrick Seed
DOI: 10.1093/ofid/ofx163.490
PubMed: 30153231
2017

Rapid enteric testing to permit targeted antimicrobial therapy, with and without Lactobacillus reuteri probiotics, for paediatric acute diarrhoeal disease in Botswana: A pilot, randomized, factorial, controlled trial
PLoS ONE
Pernica, J.M. and Steenhoff, A.P. and Mokomane, M. and Moorad, B. and Lechiile, K. and Smieja, M. and Mazhani, L. and Cheng, J. and Kelly, M.S. and Loeb, M. and Stordal, K. and Goldfarb, D.M.
DOI: 10.1371/journal.pone.0185177
2017

Hospital-acquired gastroenteritis at a referral hospital in Gaborone, Botswana
International Journal of Infection Control
Henry Welch and David M. Goldfarb and Banno Moorad and Margaret Mokomane and Marek Smieja and Unoda Chakalisa and Andrew P Steenhoff and Rodney Finalle and Susan E Coffin
DOI: 10.3396/ijic.v13i2.006.17
2017

The Nasopharyngeal Microbiota of Children with Respiratory Infections in Botswana
Pediatric Infectious Disease Journal
Kelly, M.S. and Surette, M.G. and Smieja, M. and Pernica, J.M. and Rossi, L. and Luinstra, K. and Steenhoff, A.P. and Feemster, K.A. and Goldfarb, D.M. and Arscott-Mills, T. and Boiditswe, S. and Rulaganyang, I. and Muthoga, C. and Gaofiwe, L. and Mazhani, T. and Rawls, J.F. and Cunningham, C.K. and Shah, S.S. and Seed, P.C.
DOI: 10.1097/INF.0000000000001607
2017

Correlation of clinical outcomes with multiplex molecular testing of stool from children admitted to hospital with gastroenteritis in Botswana
Journal of the Pediatric Infectious Diseases Society
Pernica, J.M. and Steenhoff, A.P. and Welch, H. and Mokomane, M. and Quaye, I. and Arscott-Mills, T. and Mazhani, L. and Lechiile, K. and Mahony, J. and Smieja, M. and Goldfarb, D.M.
DOI: 10.1093/jpids/piv028
2016

Cost-effectiveness of universal and targeted newborn screening for congenital cytomegalovirus infection
JAMA Pediatrics
Gantt, S. and Dionne, F. and Kozak, F.K. and Goshen, O. and Goldfarb, D.M. and Park, A.H. and Boppana, S.B. and Fowler, K.
DOI: 10.1001/jamapediatrics.2016.2016
2016

Enteric Parasites in Arctic Communities: Tip of the Iceberg?
Trends in Parasitology
Yansouni, C.P. and Pernica, J.M. and Goldfarb, D.
DOI: 10.1016/j.pt.2016.08.004
2016

Effectiveness of Monovalent Rotavirus Vaccine after Programmatic Implementation in Botswana: A Multisite Prospective Case-Control Study
Clinical Infectious Diseases
Gastañaduy, P.A. and Steenhoff, A.P. and Mokomane, M. and Esona, M.D. and Bowen, M.D. and Jibril, H. and Pernica, J.M. and Mazhani, L. and Smieja, M. and Tate, J.E. and Parashar, U.D. and Goldfarb, D.M.
DOI: 10.1093/cid/civ1207
2016

Molecular Detection of Diarrheal Pathogens
Clinical Microbiology Newsletter
Smieja, M. and Goldfarb, D.M.
DOI: 10.1016/j.clinmicnews.2016.08.001
2016

A comparison of flocked swabs and traditional swabs, using multiplex real-time PCR for detection of common gastroenteritis pathogens in Botswana
Diagnostic Microbiology and Infectious Disease
Mokomane, M. and Kasvosve, I. and Gaseitsiwe, S. and Steenhoff, A.P. and Pernica, J.M. and Lechiile, K. and Luinstra, K. and Smieja, M. and Goldfarb, D.M.
DOI: 10.1016/j.diagmicrobio.2016.07.007
2016

Impact of Rotavirus Vaccination on Hospitalizations and Deaths from Childhood Gastroenteritis in Botswana
Clinical Infectious Diseases
Enane, L.A. and Gastañaduy, P.A. and Goldfarb, D.M. and Pernica, J.M. and Mokomane, M. and Moorad, B. and Masole, L. and Tate, J.E. and Parashar, U.D. and Steenhoff, A.P.
DOI: 10.1093/cid/civ1210
2016

Prevalence and molecular characterization of Cryptosporidium spp. and Giardia duodenalis in diarrhoeic patients in the Qikiqtani Region, Nunavut, Canada
International Journal of Circumpolar Health
Iqbal, A. and Goldfarb, D.M. and Slinger, R. and Dixon, B.R.
DOI: 10.3402/ijch.v74.27713
2015

Optimizing Management of Pediatric Diarrhoeal Disease in Botswana: A Pilot, Factorial, Randomized, Placebo-Controlled Trial of Rapid Enteric Diagnostics and Probiotic Therapy
Open Forum Infectious Diseases
Jeffrey Pernica and Andrew Steenhoff and Margaret Mokomane and Kwana Lechiile and Banno Moorad and Marek Smieja and Loeto Mazhani and Mark Loeb and Ketil Stordal and David Goldfarb
DOI: 10.1093/ofid/ofv133.1177
2015

Association of respiratory viruses with outcomes of severe childhood pneumonia in Botswana
PLoS ONE
Kelly, M.S. and Smieja, M. and Luinstra, K. and Wirth, K.E. and Goldfarb, D.M. and Steenhoff, A.P. and Arscott-Mills, T. and Cunningham, C.K. and Boiditswe, S. and Sethomo, W. and Shah, S.S. and Finalle, R. and Feemster, K.A.
DOI: 10.1371/journal.pone.0126593
2015

Bordetella species other than bordetella pertussis
Clinical Microbiology Newsletter
Srigley, J.A. and Goldfarb, D.M. and Pernica, J.M.
DOI: 10.1016/j.clinmicnews.2015.03.004
2015

Risk factors for measles in HIV-infected children and adolescents in Botswana
Pediatric Infectious Disease Journal
Wirth, K.E. and Wolf, E.R. and Goldfarb, D.M. and Ho-Foster, A. and Tolle, M. and Jacovides, C. and Kirk, B. and Chise, M. and Steenhoff, A.P.
DOI: 10.1097/INF.0000000000000816
2015

Evaluation of anatomically designed flocked rectal swabs for molecular detection of enteric pathogens in children admitted to hospital with severe gastroenteritis in botswana
Journal of Clinical Microbiology
Goldfarb, D.M. and Steenhoff, A.P. and Pernica, J.M. and Chong, S. and Luinstra, K. and Mokomane, M. and Mazhani, L. and Quaye, I. and Goercke, I. and Mahony, J. and Smieja, M.
DOI: 10.1128/JCM.01894-14
2014

CT before lumbar puncture in suspected meningitis in Botswana: How established guidelines may not apply
African Journal of Emergency Medicine
Kestler, A. and Caruso, N. and Chandra, A. and Goldfarb, D. and Haas, M.
DOI: 10.1016/j.afjem.2013.07.004
2014

Early childhood diarrhoeal diseases and cognition: Are we missing the rest of the iceberg?
Paediatrics and International Child Health
Macintyre, J. and McTaggart, J. and Guerrant, R.L. and Goldfarb, D.M.
DOI: 10.1179/2046905514Y.0000000141
2014

Hospital-Based Surveillance for Rotavirus Gastroenteritis using Molecular Testing and Immunoassay During the 2011 Season in Botswana
The Pediatric Infectious Disease Journal
Henry Welch and Andrew P. Steenhoff and Unoda Chakalisa and Tonya Arscott-Mills and Loeto Mazhani and Margaret Mokomane and Sara Foster-Fabiano and Kathleen E. Wirth and Andrew Skinn and Jeffrey M. Pernica and Marek Smieja and David M. Goldfarb
DOI: 10.1097/inf.0b013e3182847295
05/2013

Microbiology of Urinary Tract Infections in Gaborone, Botswana
PLoS ONE
Andrew J. Renuart and David M. Goldfarb and Margaret Mokomane and Ephraim O. Tawanana and Mohan Narasimhamurthy and Andrew P. Steenhoff and Jonathan A. Silverman
DOI: 10.1371/journal.pone.0057776
03/2013

Nanolitre real-time PCR detection of bacterial, parasitic, and viral agents from patients with diarrhoea in Nunavut, Canada
International Journal of Circumpolar Health
Goldfarb, D.M. and Dixon, B. and Moldovan, I. and Barrowman, N. and Mattison, K. and Zentner, C. and Baikie, M. and Bidawid, S. and Chan, F. and Slinger, R.
DOI: 10.3402/ijch.v72i0.19903
2013

Severe late-onset multisystem cytomegalovirus infection in a premature neonate previously treated for congenital infection
BMC Pediatrics
El-Sayed, M.F. and Goldfarb, D.M. and Fulford, M. and Pernica, J.M.
DOI: 10.1186/1471-2431-13-142
2013

Hospital-based surveillance for rotavirus gastroenteritis using molecular testing and immunoassay during the 2011 season in Botswana
Pediatric Infectious Disease Journal
Welch, H. and Steenhoff, A.P. and Chakalisa, U. and Arscott-Mills, T. and Mazhani, L. and Mokomane, M. and Foster-Fabiano, S. and Wirth, K.E. and Skinn, A. and Pernica, J.M. and Smieja, M. and Goldfarb, D.
DOI: 10.1097/INF.0b013e3182847295
2013

Yield of contact tracing from pediatric tuberculosis index cases in Gaborone, Botswana
International Journal of Tuberculosis and Lung Disease
Puryear, S. and Seropola, G. and Ho-Foster, A. and Arscott-Mills, T. and Mazhani, L. and Firth, J. and Goldfarb, D.M. and Ncube, R. and Bisson, G.P. and Steenhoff, A.P.
DOI: 10.5588/ijtld.12.0933
2013

Development and evaluation of global child health educational modules
Pediatrics
Audcent, T.A. and MacDonnell, H.M. and Moreau, K.A. and Hawkes, M. and Sauve, L.J. and Crockett, M. and Fisher, J.A. and Goldfarb, D.M. and Hunter, A.J. and McCarthy, A.E. and Pernica, J.M. and Liu, J. and Luong, T.-N. and Sandhu, A.K. and Rashed, S. and Levy, A. and Brenner, J.L.
DOI: 10.1542/peds.2013-1534
2013

Rapid PCR detection of group a streptococcus from flocked throat swabs: A retrospective clinical study
Annals of Clinical Microbiology and Antimicrobials
Slinger, R. and Goldfarb, D. and Rajakumar, D. and Moldovan, I. and Barrowman, N. and Tam, R. and Chan, F.
DOI: 10.1186/1476-0711-10-33
2011

Prevalence of methicillin-resistant Staphylococcus aureus colonization in children and adolescents admitted to CHEO
Paediatrics and Child Health
Pernica, J.M. and Grzyb, M. and Goldfarb, D.M. and Slinger, R. and Suh, K.
2010

Index of suspicion.
Pediatrics in review / American Academy of Pediatrics
Liu, H. and Patel, R. and Lee, B. and Pernica, J.M. and Goldfarb, D. and Harrison, M.E.
2009

Detection of plasmid-mediated KPC-producing Klebsiella pneumoniae in Ottawa, Canada: Evidence of intrahospital transmission
Journal of Clinical Microbiology
Goldfarb, D. and Harvey, S.-B. and Jessamine, K. and Jessamine, P. and Toye, B. and Desjardins, M.
DOI: 10.1128/JCM.00098-09
2009

Assessment of flocked swabs for use in identification of streptococcal pharyngitis
Journal of Clinical Microbiology
Goldfarb, D.M. and Slinger, R. and Tam, R.K. and Barrowman, N. and Chan, F.
DOI: 10.1128/JCM.01163-09
2009

Protocol for management of imported pediatric malaria decreases time to medication administration
Pediatric Infectious Disease Journal
Goldfarb, D.M. and Gaboury, I. and Dayneka, N. and Saux, N.L.
DOI: 10.1097/INF.0b013e3181a3d12f
2009

Seasonal timing of the Royal College examination in general paediatrics: A survey of residents' preferences
Paediatrics and Child Health
Brill, H. and Benchimol, E.I. and Goldfarb, D.
2007

Case 2: Newborn with jaundice and "hyperglycemia"
Paediatrics and Child Health
Goldfarb, D. and Chakraborty, P.
2006

Research

Gastrointestinal Infections in the Arctic
Nunavut has an unusually high infection rate of cryptosporidium, a parasite that causes abdominal cramps and diarrhea. Children in the region are particularly impacted by these infections. When coupled with malnutrition, the parasite could affect early brain development. I am involved in a registry aimed at documenting enteric infections in the Canadian Arctic and am also leading a prospective study to investigate outcomes of pediatric cryptosporidium infections in Northern communities.

Improving Neonatal Care in Malawi
Malawi has the highest preterm delivery rate (18%) in the world. Inadequate newborn care at the facility level, particularly care of preterm infants, has resulted in an unacceptably high neonatal mortality rate in Malawi. I am a co-principal investigator on a project aimed at implementing various simple, life-saving, evidence-based interventions into routine clinical practice at Malawi hospitals.We hope that our program will result in reduced neonatal mortality and that our knowledge can be applied to other sub-saharan countries.

Point of Care Testing of Gastroenteritis in Botswana:
I am leading a team of collaborators from the University of Pennsylvania, University of Botswana and McMaster that plans to design an innovative, user- and patient-friendly sample collection method that will allow for point of care testing for gastroenteritis. Combined with more recent, highly sensitive detection techniques, this work could have immediate impact in much of the world where diarrheal disease remains deadly and for the large part undiagnosed.

Grants

2015 Apr - 2018 Mar. Yansouni, C (PI), Goldfarb, DM (co-PI), Diarrheal Illness and Enteric Infections Among Young Children in Nunavik and Nunavut, ArcticNet PhaseIV, Research - $120,000 (awarded)

2015 Apr - 2020 Mar. Dube, Q (PI), Goldfarb, DM (co-PI), Integrating a Neonatal Health Care Package in Malawi, International Development Research Centre/CIHR - $1,000,000 (awarded)

2015 Jan - 2016 Jan. Goldfarb DM (PI), Building an Arctic Enteric Infections Research Agenda. Canadian Institutes of Health Research Planning and Dissemination Grant, $12,000

Honours & Awards

2008 University of Ottawa, Dept of Pathology & Lab Medicine Annual Research Day - 2nd prize

2008 Children’s Hospital of Eastern Ontario, Popham Fellowship

2008 Children’s Hospital of Eastern Ontario Research Institute, Best Sub-specialty Resident Presentation

Research Group Members

Abdullah Hafeez, Clinical Trainee
Iryna Kayda, Graduate Student
Hannah Nelson, Research Assistant