My area of research is congenital heart disease. The focus is a) the use of echocardiography to assess cardiac and vascular function with and without exercise and also b) fetal echocardiography.
Stress Echocardiographic Evaluation for D-Transposition of the Great Arteries after Atrial Redirection: Unmasking Early Signs of Myocardial Dysfunction and Baffle Stenosis.
Dvir-Orgad M and Anand M and De Souza AM and Zadorsky MT and Kiess MC and Potts JE and Sandor GG
Noninvasive Assessment of Vascular Function in Postoperative Cardiovascular Disease (Coarctation of the Aorta, Tetralogy of Fallot, and Transposition of the Great Arteries).
Mivelaz Y and Leung MT and Zadorsky MT and De Souza AM and Potts JE and Sandor GG
Characterization of Myocardial Repolarization Reserve in Adolescent Females With Anorexia Nervosa.
Padfield GJ and Escudero CA and DeSouza AM and Steinberg C and Gibbs K and Puyat JH and Lam PY and Sanatani S and Sherwin E and Potts JE and Sandor G and Krahn AD
An Echocardiographic Study of Left Ventricular Size and Cardiac Function in Adolescent Females with Anorexia Nervosa.
Escudero CA and Potts JE and Lam PY and De Souza AM and Mugford GJ and Sandor GG
Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome.
Lee L and Cui JZ and Cua M and Esfandiarei M and Sheng X and Chui WA and Xu MH and Sarunic MV and Beg MF and van Breemen C and Sandor GG and Tibbits GF
Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration.
Pitcher A and Emberson J and Lacro RV and Sleeper LA and Stylianou M and Mahony L and Pearson GD and Groenink M and Mulder BJ and Zwinderman AH and De Backer J and De Paepe AM and Arbustini E and Erdem G and Jin XY and Flather MD and Mullen MJ and Child AH and Forteza A and Evangelista A
Obesity and arterial stiffness in children: systematic review and meta-analysis.
Cote AT and Phillips AA and Harris KC and Sandor GG and Panagiotopoulos C and Devlin AM
A randomized, double blind pilot study to assess the effects of losartan vs. atenolol on the biophysical properties of the aorta in patients with Marfan and Loeys-Dietz syndromes.
Sandor GG and Alghamdi MH and Raffin LA and Potts MT and Williams LD and Potts JE and Kiess M and van Breemen C
Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.
Visscher H and Rassekh SR and Sandor GS and Caron HN and van Dalen EC and Kremer LC and van der Pal HJ and Rogers PC and Rieder MJ and Carleton BC and Hayden MR and Ross CJ and CPNDS consortium
Response to: echocardiography assessment of the aorta in children with chronic kidney disease.
Alghamdi M and De Souza AM and White CT and Potts MT and Warady BA and Furth SL and Kimball TR and Potts JE and Sandor GG
Noninvasive assessment of vascular function and hydraulic power and efficiency in pediatric Fontan patients.
Myers KA and Leung MT and Terri Potts M and Potts JE and Sandor GG
Echo-Doppler assessment of arterial stiffness in pediatric patients with Kawasaki disease.
AlHuzaimi A and Al Mashham Y and Potts JE and De Souza AM and Sandor GG
Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children.
Visscher H and Ross CJ and Rassekh SR and Sandor GS and Caron HN and van Dalen EC and Kremer LC and van der Pal HJ and Rogers PC and Rieder MJ and Carleton BC and Hayden MR and CPNDS Consortium
Physical activity recommendations for patients with electrophysiologic and structural congenital heart disease: a survey of Canadian health care providers.
Roston TM and De Souza AM and Sandor GG and Sanatani S and Potts JE
Echo-Doppler assessment of the biophysical properties of the aorta in children with chronic kidney disease.
Alghamdi M and De Souza AM and White CT and Potts MT and Warady BA and Furth SL and Kimball TR and Potts JE and Sandor GG
Anthracycline induced cardiac toxicity in pediatric Ewing sarcoma: a longitudinal study.
Brown TR and Vijarnsorn C and Potts J and Milner R and Sandor GG and Fryer C
Population-based review of tetralogy of Fallot with absent pulmonary valve: is prenatal diagnosis really associated with a poor prognosis?
Mivelaz Y and Lim KI and Templeton C and Campbell AI and Potts JE and Sandor GG
Biophysical properties of the aorta and left ventricle and exercise capacity in obese children.
Harris KC and Al Saloos HA and De Souza AM and Sanatani S and Hinchliffe M and Potts JE and Sandor GG
Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children.
Visscher H and Ross CJ and Rassekh SR and Barhdadi A and Dubé MP and Al-Saloos H and Sandor GS and Caron HN and van Dalen EC and Kremer LC and van der Pal HJ and Brown AM and Rogers PC and Phillips MS and Rieder MJ and Carleton BC and Hayden MR and Canadian Pharmacogenomics Network for Drug Safety Consortium
Exercise-induced intrapulmonary arteriovenous shunt in healthy women.
Kennedy JM and Foster GE and Koehle MS and Potts JE and Sandor GG and Potts MT and Houghton KM and Henderson WR and Sheel AW
Successful treatment of acute lymphoblastic leukemia in a child with trisomy 21 and complex congenital heart disease with mechanical prosthetic valve.
Alvi S and Shereck E and Heran MK and Sandor GG and Rassekh SR
Serial measurements of exercise performance in pediatric heart transplant patients using stress echocardiography.
Yeung JP and Human DG and Sandor GG and De Souza AM and Potts JE
Primary pulmonary arterial hypertension and autoimmune polyendocrine syndrome in a pediatric patient.
Alghamdi MH and Steinraths M and Panagiotopoulos C and Potts JE and Sandor GG
Early changes in the biophysical properties of the aorta in pre-adolescent children born small for gestational age.
Bradley TJ and Potts JE and Lee SK and Potts MT and De Souza AM and Sandor GG
Does biventricular pacing improve hemodynamics in children undergoing routine congenital heart surgery?
Jeewa A and Pitfield AF and Potts JE and Soulikias W and DeSouza ES and Hollinger AJ and Sandor GG and LeBlanc JG and Campbell AM and Sanatani S
Facilitated cardiac recovery in fulminant myocarditis: pediatric use of the Impella LP 5.0 pump.
Andrade JG and Al-Saloos H and Jeewa A and Sandor GG and Cheung A
Abnormal flow in the posterior descending artery: an echo Doppler clue to the anomalous origin of left anterior descending coronary artery from the pulmonary trunk.
Myers KA and Potts MT and Sandor GG
A novel method to estimate the aortic pressure waveform using B-mode ultrasound images acquired from a suprasternal view.
Leung MT and Dumont GA and Sandor GG and Potts M and Potts JE
Echocardiographic Doppler demonstrates increasing aortic pulse wave velocity (PWV) in adult patients with renal disease.
Sandor GG and Potts JE and Bradley TJ
Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome.
Chung AW and Au Yeung K and Sandor GG and Judge DP and Dietz HC and van Breemen C
A stress echocardiography study of cardiac function during progressive exercise in pediatric oncology patients treated with anthracyclines.
De Souza AM and Potts JE and Potts MT and De Souza ES and Rowland TW and Pritchard SL and Sandor GG
Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome.
Chung AW and Au Yeung K and Cortes SF and Sandor GG and Judge DP and Dietz HC and van Breemen C
Device closure of a secundum atrial septal defect in a 4-month-old infant with a marginal left ventricle following coarctation repair.
Jean-St-Michel E and Hosking MC and Potts JE and Sandor GG
Right-sided cardiac involvement in osteogenesis imperfecta.
Khashu M and Pelligra G and Sandor GG and Singh AJ
Is the nuchal index increased in fetuses with congenital structural heart defects?
Dahlgren LS and Duncan WJ and Farquarhson DF and Sandor GS and Skoll MA and Tessier F and Lim KI
Echocardiographic Doppler assessment of the biophysical properties of the aorta in pediatric patients with the Marfan syndrome.
Bradley TJ and Potts JE and Potts MT and DeSouza AM and Sandor GG
Repair in infancy of right aortic arch with aberrant left brachiocephalic artery in the setting of a variant of the hypoplastic left heart syndrome.
Sett SS and Mawson JB and Sandor GG
Diagnosis and outcome of dextrocardia diagnosed in the fetus.
Walmsley R and Hishitani T and Sandor GG and Lim K and Duncan W and Tessier F and Farquharson DF and Potts JE
Parents' perspectives on decision making after antenatal diagnosis of congenital heart disease.
Rempel GR and Cender LM and Lynam MJ and Sandor GG and Farquharson D
Myocardial contractility in premature neonates with and without patent ductus arteriosus.
Barlow AJ and Ward C and Webber SA and Sinclair BG and Potts JE and Sandor GG
A novel Doppler echocardiographic method of measuring the biophysical properties of the aorta in pediatric patients.
Sandor GG and Hishitani T and Petty RE and Potts MT and Desouza A and Desouza E and Potts JE
Coronary arterial abnormalities in pulmonary atresia with intact ventricular septum diagnosed during fetal life.
Sandor GG and Cook AC and Sharland GK and Ho SY and Potts JE and Anderson RH
Pulmonary atresia with intact ventricular septum: range of morphology in a population-based study.
Daubeney PE and Delany DJ and Anderson RH and Sandor GG and Slavik Z and Keeton BR and Webber SA and United Kingdom and Ireland Collaborative Study of Pulmonary Atresia with Intact Ventricular Septum
"Masked" pulmonary venous obstruction in patients with isomerism of the right atrial appendages: an overstated association.
Becket Mahnke C and Sandor GG and Boyle GJ and Webber SA
Postpericardiotomy syndrome: no evidence for a viral etiology.
Webber SA and Wilson NJ and Junker AK and Byrne SK and Perry A and Thomas EE and Book L and Tipple M and Patterson MW and Sandor GG
Echocardiography and pulmonary function testing in childhood onset systemic lupus erythematosus.
Al-Abbad AJ and Cabral DA and Sanatani S and Sandor GG and Seear M and Petty RE and Malleson PN
Cardiac responses to progressive exercise in normal children: a synthesis.
Rowland T and Potts J and Potts T and Sandor G and Goff D and Ferrone L
Cardiovascular responses to exercise in children and adolescents with myocardial dysfunction.
Rowland T and Potts J and Potts T and Son-Hing J and Harbison G and Sandor G
[Standards of pediatric echocardiography]
Smallhorn JF and Fouron JC and Robertson MA and Sandor G
Standards for training in pediatric echocardiography. Canadian Cardiovascular Society.
Fouron JC and Robertson MA and Sandor G
Differences in dose scheduling as a factor in the etiology of anthracycline-induced cardiotoxicity in Ewing sarcoma patients.
Kakadekar AP and Sandor GG and Fryer C and Chan KW and Rogers PC and Pritchard S and Popov R
Effectiveness of primary level antenatal screening for severe congenital heart disease: a population-based assessment.
Sinclair BG and Sandor GG and Farquharson DF
Short- and long-term variability of echocardiographic stress-velocity indexes of cardiac function in a pediatric population.
Sandor GG and Webber SA and Popov RO and DeSouza E and Johnston B
Influence of competitive pulmonary blood flow on the bidirectional superior cavopulmonary shunt. A multi-institutional study.
Webber SA and Horvath P and LeBlanc JG and Slavik Z and Lamb RK and Monro JL and Reich O and Hruda J and Sandor GG and Keeton BR
Pulmonary artery banding is not contraindicated in double inlet left ventricle with transposition and aortic arch obstruction.
Webber SA and LeBlanc JG and Keeton BR and Salmon AP and Sandor GG and Lamb RK and Monro JL
Guidelines for monitoring of anthracycline cardiomyopathy: a rebuttal.
Steinherz LJ and Graham T and Hurwitz R and Sondheimer HM and Schaffer EM and Schwartz RG and Sandor G and Benson L and Williams R
Angiographic demonstration of endocardial fibroelastosis in an infant with critical aortic stenosis.
Ward CJ and Culham JA and Mawson J and Sandor GG
Double-blind placebo-controlled trial of corticosteroids in children with postpericardiotomy syndrome.
Wilson NJ and Webber SA and Patterson MW and Sandor GG and Tipple M and LeBlanc J
Pulmonary vascular disease in neonates with transposition of the great arteries and intact ventricular septum.
Kumar A and Taylor GP and Sandor GG and Patterson MW
Immunogenicity of Haemophilus influenzae type b conjugate vaccine in children with congenital asplenia.
Webber SA and Sandor GG and Patterson MW and Mitchell LA and Scheifele D and Ochnio JJ and McVerry PH
Autoantibody production after cardiopulmonary bypass with special reference to postpericardiotomy syndrome.
Webber SA and Wilson NJ and Fung MY and Malleson PN and Petty RE and Patterson MW and Sandor GG
Early prediction of anthracycline cardiomyopathy using standard M-mode and digitized echocardiography.
Sandor GG and Puterman M and Rogers P and Chan KW and Pritchard S and Popov R
Doppler echocardiographic observations of diastolic trans-septal flow through small ventricular septal defects.
Webber SA and Sandor GG and Patterson MW
Guidelines for cardiac monitoring of children during and after anthracycline therapy: report of the Cardiology Committee of the Childrens Cancer Study Group.
Steinherz LJ and Graham T and Hurwitz R and Sondheimer HM and Schwartz RG and Shaffer EM and Sandor G and Benson L and Williams R
Rate-corrected mean velocity of fiber shortening-stress at peak systole as a load-independent measure of contractility.
Sandor GG and Popov R and De Souza E and Morris S and Johnston B
Congenital heart disease and Robinow syndrome: coincidence or an additional component of the syndrome?
Webber SA and Wargowski DS and Chitayat D and Sandor GG
Optimal choice of prognostic variables with an application to cardiac monitoring using M-mode echocardiography.
Puterman ML and Schumacher P and Sandor GG
The clinical value and risks of lung biopsy in children with congenital heart disease.
Wilson NJ and Seear MD and Taylor GP and LeBlanc JG and Sandor GG
Assessment of bedside umbilical vein balloon septostomy using two-dimensional echocardiographic guidance in transposition of great arteries.
D'Orsogna L and Lam J and Sandor GG and Patterson MW
Influence of echocardiography in pre-operative cardiac catheterization in congenital heart disease.
D'Orsogna L and Sandor GG and Patterson MW and Ashmore PG and LeBlanc J and Culham JA
Role of prenatal detection of cardiac tumours in the diagnosis of tuberous sclerosis--report of two cases.
Chitayat D and McGillivray BC and Diamant S and Wittmann BK and Sandor GG
Left ventricular systolic and diastolic function after two-stage anatomic correction of transposition of the great arteries.
Sandor GS and Freedom RM and Williams WG and LeBlanc J and Trusler G and Patterson MW and Ashmore PG
Pulmonary artery banding: results and current indications in pediatric cardiac surgery.
LeBlanc JG and Ashmore PG and Pineda E and Sandor GG and Patterson MW and Tipple M
Left ventricular systolic and diastolic function after total correction of tetralogy of Fallot.
Sandor GG and Patterson MW and Tipple M and Ashmore PG and Popov R
Effect of pressure loading, volume loading and surgery on left ventricular chamber and myocardial stiffness in congenital heart disease, with a reevaluation of normal pediatric values.
Sandor GG and Puterman ML and Patterson MW and Tipple MA and Vince DJ
Treatment of grafts and major vessel thrombosis with low-dose streptokinase in children.
LeBlanc JG and Culham JA and Chan KW and Patterson MW and Tipple M and Sandor GG
Fetal echocardiography: results in high-risk patients.
Sandor GG and Farquarson D and Wittmann B and Chow TC and Lau AE
Cardiovascular therapy in the newborn.
Clinical and echocardiographic evidence suggesting afterload reduction as a mechanism of action of tolazoline in neonatal hypoxemia.
Sandor GG and Macnab AJ and Akesode FA and Ebelt VJ and Pendray MR and Ling WY and Patterson MW and Tipple MA
Successful palliation by pulmonary artery banding in absent pulmonary valve syndrome with aneurysmal pulmonary arteries.
Opie JC and Sandor GG and Ashmore PG and Patterson MW
Serum digoxin levels in neonates under 1500 grams.
Sandor GG and Reid G and Patterson MW
Determination of left ventricular diastolic chamber stiffness and myocardial stiffness in patients with congenital heart disease.
Sandor GG and Olley PM
Serum digoxin levels in neonates whose weights are less than 1,500 grams.
Patterson MW and Reid G and Sandor GG
Intrinsic defects in the fetal alcohol syndrome: studies on 76 cases from British Columbia and the Yukon Territory.
Smith DF and Sandor GG and MacLeod PM and Tredwell S and Wood B and Newman DE
Long-term follow-up of patients after valvotomy for congenital valvular aortic stenosis in children: a clinical and actuarial follow-up.
Sandor GG and Olley PM and Trusler GA and Williams WG and Rowe RD and Morch JE
Noninvasive assessment of left ventricular function related to serum digoxin levels in neonates.
Sandor GG and Bloom KR and Izukawa T and Patterson MW and Rowe RD
Structure and function of the heart can be examined using ultrasound. My interest lies in using the latest ultrasound to characterize the heart’s ability to pump and to fill. This work attempts to accurately assess and diagnose abnormalities of function early, and to compare the results of different types of medical and surgical treatment to evaluate outcome. Our laboratory has been a pioneer in the simplification of non-invasive methods of assessing heart function and we have also developed a new technique to quantify the properties of the major blood vessels coming from the heart to see whether these are diseased or healthy. We are also examining the interaction of heart function with the properties of the blood vessels to see how efficient the heart and circulation are. These types of studies are of importance in patients who have some compromise of cardiac function, so that therapy may be optimised to enable the heart to work most efficiently.
Our laboratory has devised a technique whereby the heart can be imaged with ultrasound during exercise and with this technique are able to obtain indexes of cardiac function, cardiac output and examine the heart muscle contractility using stage exercise. This technique is unique and has been extremely useful in assessing the cardiac reserve in patients for whom decisions have to be made with regard to surgery, continuing potentially cardiotoxic medications and assessing the effects of these. This has been found very helpful in situations where the examination of the heart at rest has not provided enough information about the potential heart to do exercise. In addition, this technique has been very helpful in unmasking a partial blockage in blood vessels whereby exercise increased the cardiac output and has demonstrated a significant degree of obstruction that is not apparent in the resting state. We have undertaken some of this work for the Adult Congenital Heart Disease Program.
The antenatal diagnosis of congenital heart disease continues to develop and we have been one of the first centers to institute a fetal cardiac diagnosis program. This is unique in that it integrates perinatology and the fetal diagnosis program, which help in the management of these difficult situations. In addition to evaluating the accuracy of this technique, we have also examined issues of outcomes, population statistics and just as importantly, a qualitative study of such diagnoses. We have also started to use an adaptation of the technique of assessment of the vascular properties by ultrasound (alluded to in the previous paragraphs) to attempt to assess fetal circulatory health, and we hope that this test will give us further insights into placental insufficiency and perhaps an earlier diagnosis of such problems.