My research interests are in the area of Allergy and Clinical Immunology. The immune system plays a critical role in protecting hosts from infection. Primary immunodeficiency encompasses a group of disorders whereby parts of the immune system may be defective or missing, often resulting in severe, invasive or recurrent infections, autoimmunity and malignancy. The genetic makeup of an individual and the response of the immune system to external environmental factors can result in allergic disorders and disease. There is a strong relationship between conditions such as asthma, food allergy and atopic dermatitis - all of which have an underlying immunological basis. My research aims to study these disorders and apply knowledge translation strategies to empower patients, families and their physicians.
Vaccine anaphylaxis and Canadian public health policy
The Lancet Respiratory Medicine
Abrams, E.M. and Zafack, J.G. and Ismail, S.J. and Bettinger, J.A. and Hildebrand, K.J. and Tunis, M.C.
DOI: 10.1016/S2213-2600(23)00037-1
2023
Evaluation of rotavirus vaccine administration among a 22q11.2DS patient population
Allergy, Asthma & Clinical Immunology
Sophie McGregor and Matthew Boroditsky and Geraldine Blanchard-Rohner and Christine Loock and Kyla Jade Hildebrand
DOI: 10.1186/s13223-022-00693-z
12/2022
Real-world peanut OIT in infants may be safer than non-infant preschool OIT and equally effective
Journal of Allergy and Clinical Immunology: In Practice
Soller, L. and Carr, S. and Kapur, S. and Rex, G.A. and McHenry, M. and Cook, V.E. and Leo, S. and Wong, T. and Vander Leek, T.K. and Gerstner, T.V. and Yeung, J. and Abrams, E.M. and Mak, R. and Hildebrand, K.J. and Erdle, S.C. and Cameron, S.B. and Chan, E.S.
DOI: 10.1016/j.jaip.2021.12.009
2022
Revaccination and Adverse Event Recurrence in Patients with Adverse Events following Immunization
Journal of Pediatrics
Mu{\~n}oz, C.E. and MacDonald, B. and Pham-Huy, A. and Vaudry, W. and Pernica, J.M. and Boucher, F.D. and Constantinescu, C. and Sadarangani, M. and Bettinger, J.A. and Tapi{\'e}ro, B. and Morris, S.K. and McConnell, A. and Cowan, J. and Zafack, J. and Upton, J. and Abdurrahman, Z. and McHenry, M. and Hildebrand, K.J. and Noya, F. and De Serres, G. and Halperin, S.A. and Top, K.A.
DOI: 10.1016/j.jpeds.2022.07.019
2022
Inborn errors of immunity manifesting as atopic disorders.
The Journal of allergy and clinical immunology
Vaseghi-Shanjani M and Smith KL and Sara RJ and Modi BP and Branch A and Sharma M and Lu HY and James EL and Hildebrand KJ and Biggs CM and Turvey SE
DOI: 10.1016/j.jaci.2021.08.008
PubMed: 34428518
08/2021
Diverse clinical features and diagnostic delay in monogenic inborn errors of immunity: A call for access to genetic testing.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Branch A and Modi B and Bahrani B and Hildebrand KJ and Cameron SB and Junker AK and Turvey SE and Biggs CM
DOI: 10.1111/pai.13571
PubMed: 34097760
06/2021
Prevention and management of allergic reactions to food in child care centers and schools: Practice guidelines.
The Journal of allergy and clinical immunology
Waserman S and Cruickshank H and Hildebrand KJ and Mack D and Bantock L and Bingemann T and Chu DK and Cuello-Garcia C and Ebisawa M and Fahmy D and Fleischer DM and Galloway L and Brozek JL
DOI: 10.1016/j.jaci.2021.01.034
PubMed: 33965093
05/2021
L'évaluation et la prise en charge des allergies alimentaires non induites par les IgE.
Paediatrics & child health
Abrams EM and Hildebrand KJ and Chan ES
DOI: 10.1093/pch/pxaa132
PubMed: 33936338
04/2021
Non-IgE-mediated food allergy: Evaluation and management.
Paediatrics & child health
Abrams EM and Hildebrand KJ and Chan ES
DOI: 10.1093/pch/pxaa131
PubMed: 33936337
04/2021
First Real-World Effectiveness Analysis of Preschool Peanut Oral Immunotherapy
Journal of Allergy and Clinical Immunology: In Practice
Soller, L. and Abrams, E.M. and Carr, S. and Kapur, S. and Rex, G.A. and Leo, S. and McHenry, M. and Vander Leek, T.K. and Yeung, J. and Cook, V.E. and Wong, T. and Hildebrand, K.J. and Mak, R. and Gerstner, T.V. and Cameron, S.B. and Chan, E.S.
DOI: 10.1016/j.jaip.2020.10.045
2021
Anaphylaxis to parenteral nutrition in a pediatric oncology patient treated with induction of drug tolerance protocol
Journal of Allergy and Clinical Immunology: In Practice
Wachnian, C.J. and Baadjes, B. and Cheng, S. and Ramanzin, A. and Hildebrand, K.J.
DOI: 10.1016/j.jaip.2020.10.016
2021
Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report
BMC Pediatrics
Blanchard-Rohner, G. and Ragotte, R.J. and Junker, A.K. and Sharma, M. and Del Bel, K.L. and Lu, H.Y. and Erdle, S. and Chomyn, A. and Gill, H. and Tucker, L.B. and Schreiber, R.A. and Rozmus, J. and Biggs, C.M. and Hildebrand, K.J. and Wu, J. and Stockler-Ipsiroglu, S. and Turvey, S.E.
DOI: 10.1186/s12887-021-02508-3
2021
Septic arthritis due to Mycoplasma orale in a young patient with hypogammaglobulinemia
JAMMI
Liu, A.C. and Harvey, M. and Lee, A. and Hildebrand, K. and Hoang, L. and Gantt, S. and Al-Rawahi, G.N.
DOI: 10.3138/JAMMI-2021-0002
2021
CSACI position statement: transition recommendations on existing epinephrine autoinjectors
Allergy, Asthma and Clinical Immunology
Li, L.D.X. and Abrams, E.M. and Lavine, E. and Hildebrand, K. and Mack, D.P.
DOI: 10.1186/s13223-021-00634-2
2021
First pediatric electronic algorithm to stratify risk of penicillin allergy.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Roberts H and Soller L and Ng K and Chan ES and Roberts A and Kang K and Hildebrand KJ and Wong T
DOI: 10.1186/s13223-020-00501-6
PubMed: 33292528
12/2020
Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant
Cold Spring Harbor Molecular Case Studies
Jia, A. and James, E. and Lu, H.Y. and Sharma, M. and Modi, B.P. and Biggs, C.M. and Hildebrand, K.J. and Chomyn, A. and Erdle, S. and Kular, H. and Turvey, S.E.
DOI: 10.1101/MCS.A005298
2020
First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy.
The journal of allergy and clinical immunology. In practice
Soller L and Abrams EM and Carr S and Kapur S and Rex GA and Leo S and Lidman PG and Yeung J and Vander Leek TK and McHenry M and Wong T and Cook VE and Hildebrand KJ and Gerstner TV and Chan ES
DOI: 10.1016/j.jaip.2019.04.010
PubMed: 31002957
04/2019
Timing of introduction of allergenic solids for infants at high risk.
Paediatrics & Child Health
Abrams EM and Hildebrand K and Blair B and Chan ES
DOI: 10.1093/pch/pxy195
PubMed: 30833823
02/2019
Extended analysis of parent and child confidence in recognizing anaphylaxis and using the epinephrine autoinjector during oral food challenges
Journal of Allergy and Clinical Immunology: In Practice
Soller, L. and Teoh, T. and Baerg, I. and Wong, T. and Hildebrand, K.J. and Cook, V.E. and Biggs, C.M. and Lee, N. and Yaworski, L. and Cameron, S.B. and Chan, E.S.
DOI: 10.1016/j.jaip.2018.09.025
2019
Early introduction of foods to prevent food allergy.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Chan ES and Abrams EM and Hildebrand KJ and Watson W
DOI: 10.1186/s13223-018-0286-1
PubMed: 30275847
09/2018
Asthma.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Quirt J and Hildebrand KJ and Mazza J and Noya F and Kim H
DOI: 10.1186/s13223-018-0279-0
PubMed: 30275843
09/2018
Supervised epinephrine autoinjector administration in a cohort of children with anaphylaxis during oral food challenges (OFCs)
Journal of Allergy and Clinical Immunology
Lianne Soller and Timothy Teoh and Ingrid Baerg and Tracy Gonzalez and Tiffany Wong and Kyla J. Hildebrand and Edmond S. Chan
DOI: 10.1016/j.jaci.2017.12.800
02/2018
Interstitial lung disease in infancy: an unusual presentation of CD40 ligand deficiency
LymphoSign Journal
Victoria Elizabeth Cook and Connie L Yang and Alexia Dabadie and Joanne Luider and Kyla Jade Hildebrand and Anne K Junker and Stuart Turvey
DOI: 10.14785/lymphosign-2017-0003
06/2017
THE PHENOTYPE OF SEVERE PRESCHOOL ASTHMATICS AND THEIR RESPONSE TO ADD-ON THERAPY.
Paediatrics & Child Health
Seaton C and Hildebrand K and Pow A and Yang C
DOI: 10.1093/pch/pxx086.094
05/2017
Case 3: Persistent Fever in an 8-month-old Boy
Pediatrics in Review
Megan Kilvert and Ashley Roberts and Kyla J. Hildebrand
DOI: 10.1542/pir.2015-0145
03/2017
Many Children Referred to a Tertiary Care Pediatric Allergy Clinic Do Not Have an Allergy
Journal of Allergy and Clinical Immunology
Victoria E. Cook and Jordan Yeo and Christopher Mill and Kyla Hildebrand and Elodie Portales-Casamar and Edmond S. Chan
DOI: 10.1016/j.jaci.2016.12.134
02/2017
Determinants of Quality of life (QOL) Among Children Undergoing Oral Food Challenge (OFC) in Canada
Journal of Allergy and Clinical Immunology
Lianne Soller and Christopher Mill and Tiffany Wong and Ingrid Baerg and Tracy Gonzalez and Timothy Teoh and Kyla Hildebrand and Edmond S. Chan
DOI: 10.1016/j.jaci.2016.12.137
02/2017
Primum non nocere—first do no harm. And then feed peanut
Allergy, Asthma & Clinical Immunology
Kyla Jade Hildebrand and Elissa Michele Abrams and Timothy K. Vander Leek and Julia Elizabeth Mainwaring Upton and Douglas P. Mack and Linda Kirste and Christine McCusker and Sandeep Kapur
DOI: 10.1186/s13223-017-0180-2
02/2017
Mobile health applications in clinical practice: pearls, pitfalls, and key considerations
Annals of Allergy, Asthma & Immunology
Victoria E. Cook and Anne K. Ellis and Kyla J. Hildebrand
DOI: 10.1016/j.anai.2016.01.012
08/2016
Impact of supervised epinephrine autoinjector administration during food challenges on parent confidence
Annals of Allergy, Asthma & Immunology
Timothy Teoh and Christopher Mill and Tiffany Wong and Ingrid Baerg and Angela Alexander and Kyla J. Hildebrand and John Dean and Boris Kuzeljevic and Edmond S. Chan
DOI: 10.1016/j.anai.2016.02.020
05/2016
IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae
Clinical Immunology
Serge Grazioli and Sara J. Hamilton and Margaret L. McKinnon and Kate L. Del Bel and Linda Hoang and Victoria E. Cook and Kyla J. Hildebrand and Anne K. Junker and Stuart E. Turvey
DOI: 10.1016/j.clim.2015.12.007
02/2016
Limitation of TREC-based newborn screening for ZAP70 Severe Combined Immunodeficiency
Clinical Immunology
Serge Grazioli and Mary Bennett and Kyla J. Hildebrand and Hilary Vallance and Stuart E. Turvey and Anne K. Junker
DOI: 10.1016/j.clim.2014.04.015
07/2014
Rifampin Hypersensitivity in a 2-year-old Child With Successful Rapid Oral Desensitization
The Pediatric Infectious Disease Journal
Kyla J. Hildebrand and Adelle Atkinson and Ian Kitai
DOI: 10.1097/inf.0000000000000295
07/2014
Epinephrine auto injector administration by parents or patients for anaphylaxis during supervised oral food challenges and assessment of confidence
Allergy, Asthma & Clinical Immunology
Ingrid Baerg and Angela Alexander and Tiffany Wong and Timothy Teoh and Kyla Hildebrand and Sara Leo and Joanne Yeung and John Dean and Edmond Chan
DOI: 10.1186/1710-1492-10-s2-a2
2014
Rifampin hypersensitivity in a 2-year-old child with successful rapid oral desensitization
Pediatric Infectious Disease Journal
Hildebrand, K.J. and Atkinson, A. and Kitai, I.
DOI: 10.1097/INF.0000000000000295
2014
Epinephrine auto injector administration by parents or patients for anaphylaxis during supervised oral food challenges and assessment of confidence
Allergy, Asthma and Clinical Immunology
Baerg, I. and Alexander, A. and Wong, T. and Teoh, T. and Hildebrand, K. and Leo, S. and Yeung, J. and Dean, J. and Chan, E.
DOI: 10.1186/1710-1492-10-S2-A2
2014
Human primary immunodeficiencies causing defects in innate immunity
Current Opinion in Allergy and Clinical Immunology
Tiffany Wong and Joanne Yeung and Kyla J. Hildebrand and Anne K. Junker and Stuart E. Turvey
DOI: 10.1097/aci.0000000000000010
2013
Human primary immunodeficiencies causing defects in innate immunity
Current Opinion in Allergy and Clinical Immunology
Wong, T. and Yeung, J. and Hildebrand, K.J. and Junker, A.K. and Turvey, S.E.
DOI: 10.1097/ACI.0000000000000010
2013
Vasculitis masquerading as drug allergy: thinking outside the ‘adult’ box of possible diagnoses
Allergy, Asthma & Clinical Immunology
Marie-Elodie Sarre-Annweiler and Mariamma Joseph and Kyla J Hildebrand
DOI: 10.1186/1710-1492-8-s1-a15
2012
Rifampin hypersensitivity in a two year-old child with successful rapid oral desensitization
Allergy, Asthma & Clinical Immunology
KJ Hildebrand and D Hummel
DOI: 10.1186/1710-1492-6-s1-p22
2010
Epinephrine Autoinjector Study
Caregivers and patients in Pediatric Allergy Clinic often report that they are fearful of using an epinephrine autoinjector despite receiving education on indications for use and technique. Given that intramuscular epinephrine is the only medication that can reverse a potentially severe allergic reaction, it is very important that patients and caregivers possess not only the knowledge and ability to use epinephrine autoinjectors, but also have the confidence to administer the medication when clinically indicated. The goal of the Epinephrine Autoinjector study is to assess the impact of self or caregiver-administrated epinephrine in a medically supervised setting on the confidence of patient and/or caregivers for future use of epinephrine autoinjector.
Certified Asthma Educator (CAE) Anaphylaxis Counseling Study
Several of my research projects involve studying the relationship between asthma, allergy and anaphylaxis. Many patients with severe asthma who require admission to intensive care units or repeated hospital admissions have underlying allergic triggers (environmental or food allergy). Poorly controlled asthma is a significant risk factor for anaphylaxis in this patient population. I am assessing the frequency of anaphylaxis counseling performed by a group of CAEs at BC Children’s Hospital and the outcomes associated with this counseling intervention. For patients living in remote areas of British Columbia, there is greater accessibility to CAEs in comparison to pediatric asthma/allergy specialists. There may be a role for curricular innovation to the CAE training programs across Canada to better serve this at-risk patient population.
The CHILD study
this study is a multicenter, multidisciplinary, longitudinal, population-based cohort study of 5000 children. The aim of the study is to test multiple hypotheses within the theme that specific environmental exposures along with genetic and immunological determinants, lead to pathophysiological allergic responses, and that clinical outcomes including asthma may be further modified by lung growth, hormonal and metabolic influences and psychosocial environment. Children were recruited from 4 cities in Canada, including Vancouver and are being followed prospectively.
Royal College of Physicians and Surgeons Canada Fellowship for Studies in Medical Education (2010)
Each year, the University of British Columbia faculty of medicine recognizes faculty and staff members for excellence in teaching, research, administration, innovation and public service.
Congratulations to the BC Children’s Hospital Research Institute investigators and staff members who are recognized in the 2022 UBC Faculty of Medicine Awards:
BC Children’s Hospital investigator Dr. Kyla Hildebrand not only conducts research in the area of allergy and clinical immunology, but this clinical assistant professor in the Department of Pediatrics in the Faculty of Medicine at the University of British Columbia is also well known for her leadership in undergraduate and postgraduate medical education.
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