Mary B Connolly

FRCP, MBBCH

Investigator, BC Children's Hospital
Director, Epilepsy Program, BC Children's Hospital
Co-Director, Epilepsy Surgery Program, BC Children's Hospital
President, Canadian League Against Epilepsy

My research centers on various aspects of pediatric neurology, primarily epilepsy and surgical management of epilepsy.

Epilepsy is the most common chronic neurological disorder in children and is characterized by recurrent unprovoked seizures due to uncontrolled electrical activity in the brain. Thirty per cent or more of epilepsy cases do not respond to conventional epileptic medications. Other treatments for epilepsy are epilepsy surgery, vagus nerve stimulation, the ketogenic diet and investigational anti-epileptic drugs.

The epilepsy surgery program at BC Children’s Hospital was established in the mid 90s. My research focuses on outcomes following epilepsy surgery of various types and the influence of surgery on seizure control, quality of life, learning and attention. I am also involved in research in video-EEG monitoring, psychogenic non-epileptic seizures, psychiatric comorbidity in epilepsy and adverse reactions to anti-epileptic drugs.

Academic Affiliations

  • Clinical Professor, Division of Neurology, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Brain, Behaviour & Development
  • Research Group(s): Clinical Practice, Outcomes and Innovation; Neurodevelopmental and Neurological Disorders; Rare Diseases

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

Putting control into parents' hands: Parent experiences with a genomic results e-booklet

Journal of Genetic Counseling

Shelin Adam and Patricia Gombas and Michelle Demos and Cyrus Boelman and Mary B. Connolly and Kyrstin Lavelle and Jan M. Friedman and Alison M. Elliott and Patricia Birch

DOI: 10.1002/jgc4.70095

08 / 2025

Dravet syndrome: From neurodevelopmental to neurodegenerative disease?

Epilepsia

Selvarajah, A. and Sabo, A. and Gorodetsky, C. and Marques, P.T. and Chandran, I. and Thompson, M. and Zulfiqar Ali, Q. and McAndrews, M.P. and Tartaglia, M.C. and Lira, V.S.T. and Huh, L. and Connolly, M. and Rezazadeh, A. and Qaiser, F. and Fantaneanu, T.A. and Duong, M. and Barboza, K. and Lomax, L.B. and Inuzuka Nakaharada, L. and Valente, K. and Arbinuch, J. and Espindola, M. and Garzon, E. and Sorrento, G. and Meskis, M.A. and Villas, N. and Hood, V. and Gonzalez, M. and Cardenal-Mu{\~n}oz, E. and Aiba, J.A. and McKenna, L. and Linehan, C. and Hohn, S. and Auvin, S. and Devinsky, O. and Yuen, R. and Berg, A.T. and Taati, B. and Fasano, A. and Andrade, D.M.

DOI: 10.1111/epi.18329

The current state of care for tuberous sclerosis complex in Canada

Canadian Journal of Neurological Sciences

Whitney, R. and Nouri, M.N. and Sham, L. and Muir, K. and Andrade, A.V. and Connolly, M.B. and Donner, E.J. and Evanochko, C. and Flinn, J. and House, A.A. and Kim, R.H. and Kowal, C. and Major, P. and Marques, P. and Suller Marti, A. and Trinari, E. and Valcic, M. and Wilbur, C. and Zak, M. and Keezer, M.R.

DOI: 10.1017/cjn.2025.58

Evidence demands action: An invitation to share the burden of proof

Epilepsia

Andrade, D.M. and Berg, A.T. and Selvarajah, A. and Sabo, A. and Gorodetsky, C. and Marques, P. and Chandran, I. and Thompson, M. and Ali, Q.Z. and McAndrews, M.P. and Tartaglia, M.C. and Lira, V.S.T. and Huh, L. and Connolly, M. and Rezazadeh, A. and Qaiser, F. and Fantaneanu, T.A. and Duong, M. and Barboza, K. and Lomax, L.B. and Nakaharada, L.I. and Arbinuch, J. and Espindola, M. and Garzon, E. and Sorrento, G. and Meskis, M.A. and Villas, N. and Hood, V. and Gonzalez, M. and Cardenal-Mu{\~n}oz, E. and Aibar, J.A. and McKenna, L. and Linehan, C. and Yuen, R. and Taati, B. and Fasano, A. and Devinsky, O. and Valente, K.

DOI: 10.1111/epi.18583

EEG response to high dose nocturnal diazepam in children with developmental/epileptic encephalopathy with spike-and-wave activation in sleep (DEE/EE-SWAS)

Epilepsy and Behavior

Kiani, H. and Whitney, R. and Go, C. and Puka, K. and Connolly, M.B. and Jones, K.C. and Smith, M.L. and RamachandranNair, R.

DOI: 10.1016/j.yebeh.2025.110498

Evaluating family-centred care at BC Children's Hospital: Healthcare providers' perspectives

Journal of Evaluation in Clinical Practice

Kolar, T. and Cook, C.B. and Cooper, A. and Blydt-Hansen, T. and Connolly, M.B. and Boelman, C. and Chhina, H. and Datta, A. and Demos, M. and Hildebrand, K.J. and Selby, K. and Shen, Y. and Wenderfer, S.E. and Elliott, A.M.

DOI: 10.1111/jep.14187

Improving access to epilepsy surgery: a review of the global praxis, implementation science, and relevant policy frameworks

Neurosurgical Focus

Ferraris, K.P. and Mabilangan, K.C. and Gimenez, M.L.A. and Ra{\~n}oa, G.J. and Aguilar, J.F.A. and Go, C.Y. and Connolly, M. and Zipfel, J. and Haji, F.A. and Tamber, M.S. and Singhal, A.

DOI: 10.3171/2025.1.FOCUS24805

Choroid Plexus Volume in Pediatric-Onset Multiple Sclerosis

Neurology Neuroimmunology and Neuroinflammation

Grasso, E.A. and Bloy, L. and Kaplan, P. and Bar-Or, A. and Yeh, E.A. and Arnold, D.L. and Narayanan, S. and Marrie, R.A. and Fadda, G. and Banwell, B.L. and Awuku, M. and Baird, J.B. and Bhan, V. and Buckley, D. and Callen, D. and Connolly, M.B. and Dilenge, M.-E. and Doja, A. and Levin, S. and Lortie, A. and MacDonald, E.A. and Mah, J.K. and Meaney, B. and Meek, D. and Pohl, D. and Sebire, G. and Venkateswaran, S. and Waldman, A. and Wambera, K. and Wood, E. and Yager, J.

DOI: 10.1212/NXI.0000000000200319

Expanding the genotype-phenotype spectrum in SCN8A-related disorders

BMC Neurology

Hebbar, M. and Al-Taweel, N. and Gill, I. and Boelman, C. and Dean, R.A. and Goodchild, S.J. and Mezeyova, J. and Shuart, N.G. and Johnson, J.P. and Lee, J. and Michoulas, A. and Huh, L.L. and Armstrong, L. and Connolly, M.B. and Demos, M.K.

DOI: 10.1186/s12883-023-03478-y

Seizing the moment: communicating ethics, decisions, and neurotechnological approaches to pediatric drug-resistant epilepsy

Frontiers in Communication

Illes, J. and McDonald, P.J. and Ibrahim, G.M. and Connolly, M.B. and Naftel, R.P. and Bacani, M. and Nuechterlein, A. and Go, S.P. and Roduit, J.

DOI: 10.3389/fcomm.2024.1267065

Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)

Epilepsia

Weil, A.G. and Dimentberg, E. and Lewis, E. and Ibrahim, G.M. and Kola, O. and Tseng, C.-H. and Chen, J.-S. and Lin, K.-M. and Cai, L.-X. and Liu, Q.-Z. and Lin, J.-L. and Zhou, W.-J. and Mathern, G.W. and Smyth, M.D. and O'Neill, B.R. and Dudley, R. and Ragheb, J. and Bhatia, S. and Delev, D. and Ramantani, G. and Zentner, J. and Wang, A.C. and Dorfer, C. and Feucht, M. and Czech, T. and Bollo, R.J. and Issabekov, G. and Zhu, H. and Connolly, M. and Steinbok, P. and Zhang, J.-G. and Zhang, K. and Hidalgo, E.T. and Weiner, H.L. and Wong-Kisiel, L. and Lapalme-Remis, S. and Tripathi, M. and Sarat~Chandra, P. and Hader, W. and Wang, F.-P. and Yao, Y. and Champagne, P.O. and Brunette-Clment, T. and Guo, Q. and Li, S.-C. and Budke, M. and Prez-Jimnez, M.A. and Raftopoulos, C. and Finet, P. and Michel, P. and Schaller, K. and Stienen, M.N. and Baro, V. and Cantillano~Malone, C. and Pociecha, J. and Chamorro, N. and Muro, V.L. and von Lehe, M. and Vieker, S. and Oluigbo, C. and Gaillard, W.D. and Al Khateeb, M. and Al Otaibi, F. and Krayenbhl, N. and Bolton, J. and Pearl, P.L. and Fallah, A.

DOI: 10.1111/epi.17689

Where there is no genetic counselor: An online decision-aid supports the majority of parents diagnostic genomic testing choices for their children

Genetics in Medicine

Birch, P. and Beauchesne, R. and Bansback, N. and Boelman, C. and Connolly, M. and Demos, M. and Friedman, J.M. and Race, S. and Stockler, S. and Elliott, L.M. and Austin, J. and Knoppers, B. and Lynd, L.D. and Dey, A. and Adam, S. and Clarke, L. and Dragojlovic, N. and Lambert, D. and Pullman, D. and Virani, A. and Wasserman, W. and Zawati, M. and Elliott, A.M.

DOI: 10.1016/j.gim.2024.101173

Trajectories of parent well-being in children with drug-resistant epilepsy

Epilepsia

Smith, M.L. and Puka, K. and Speechley, K.N. and Ferro, M.A. and Connolly, M.B. and Major, P. and Gallagher, A. and Almubarak, S. and Hasal, S. and Ramachandrannair, R. and Andrade, A. and Xu, Q. and Leung, E. and Snead, O.C. and Widjaja, E.

DOI: 10.1111/epi.17797

Pre-Operative Predictors of Health-Related Quality of Life Two Years After Pediatric Epilepsy Surgery: A Prospective Cohort Study

Seizure

Rojulpote, K.V. and Smith, M.L. and Puka, K. and Speechley, K.N. and Ferro, M.A. and Connolly, M.B. and Major, P. and Gallagher, A. and Almubarak, S. and Hasal, S. and Ramachandrannair, R. and Andrade, A. and Xu, Q. and Leung, E. and Snead, O.C. and Widjaja, E.

DOI: 10.1016/j.seizure.2023.08.016

A longitudinal cohort study of mediators of health-related quality of life after pediatric epilepsy surgery or medical treatment

Epilepsia

Smith, M.L. and Puka, K. and Speechley, K.N. and Ferro, M.A. and Connolly, M.B. and Major, P. and Gallagher, A. and Almubarak, S. and Hasal, S. and Ramachandrannair, R. and Andrade, A. and Xu, Q. and Leung, E. and Snead, O.C. and Widjaja, E.

DOI: 10.1111/epi.17660

Trajectory of Health-Related Quality of Life after Pediatric Epilepsy Surgery

JAMA Network Open

Widjaja, E. and Puka, K. and Speechley, K.N. and Ferro, M.A. and Connolly, M.B. and Major, P. and Gallagher, A. and Almubarak, S. and Hasal, S. and Ramachandrannair, R. and Andrade, A. and Xu, Q. and Leung, E. and Snead, O.C. and Smith, M.L.

DOI: 10.1001/jamanetworkopen.2023.4858

Added value of corpus callosotomy following vagus nerve stimulation in children with Lennox"Gastaut syndrome: A multicenter, multinational study

Epilepsia

Roth, J. and Bergman, L. and Weil, A.G. and Brunette-Clement, T. and Weiner, H.L. and Treiber, J.M. and Shofty, B. and Cukiert, A. and Cukiert, C.M. and Tripathi, M. and Sarat~Chandra, P. and Bollo, R.J. and Machado, H.R. and Santos, M.V. and Gaillard, W.D. and Oluigbo, C.O. and Ibrahim, G.M. and Jallo, G.I. and Shimony, N. and O'Neill, B.R. and Budke, M. and Prez-Jimnez, M.?. and Mangano, F.T. and Iwasaki, M. and Iijima, K. and Gonzalez-Martinez, J. and Kawai, K. and Ishishita, Y. and Elbabaa, S.K. and Bello-Espinosa, L. and Fallah, A. and Maniquis, C.A.B. and Ben-Zvi, I. and Tisdall, M. and Panigrahi, M. and Jayalakshmi, S. and Blount, J.P. and Dorfmller, G. and Bulteau, C. and Stone, S.S. and Bolton, J. and Singhal, A. and Connolly, M. and Alsowat, D. and Alotaibi, F. and Ragheb, J. and Uliel-Sibony, S.

DOI: 10.1111/epi.17796

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions

Epilepsia

Hirsch, E. and French, J. and Scheffer, I.E. and Bogacz, A. and Alsaadi, T. and Sperling, M.R. and Abdulla, F. and Zuberi, S.M. and Trinka, E. and Specchio, N. and Somerville, E. and Samia, P. and Riney, K. and Nabbout, R. and Jain, S. and Wilmshurst, J.M. and Auvin, S. and Wiebe, S. and Perucca, E. and Mosh, S. and Tinuper, P. and Wirrell, E.C. and Adikaibe, D.B. and Al Baradi, R. and Andrade, D. and Bast, T. and Beydoun, A. and Bien, C. and Caraballo, R. and Carolina Coan, A. and Connolly, M. and Dunne, J. and Haut, S. and Jansen, F. and Jobst, B. and Kalviainen, R. and Kakooza, A. and Kato, M. and Knupp, K. and Kochen, S. and Lagae, L. and Carlos Mayor, L. and Okujava, N. and Radakishnan, K. and Roulet-Perez, E. and Rios, L. and Sadleir, L. and Juan-Orta, D.S. and Serratosa, J. and Shellhaas, R. and Tsai, M.-H. and Udani, V. and Yue-Hua Zhang,, H. and Zhou., D.

DOI: 10.1111/epi.17236

Understanding Attributes that Influence Physician and Caregiver Decisions About Neurotechnology for Pediatric Drug-Resistant Epilepsy: A Formative Qualitative Study to Support the Development of a Discrete Choice Experiment

Patient

Apantaku, G. and Aguiar, M. and Kaal, K.J. and McDonald, P.J. and Connolly, M.B. and Hrincu, V. and Illes, J. and Harrison, M.

DOI: 10.1007/s40271-021-00544-w

Targeted Whole Exome Sequencing in Children With Early-Onset Epilepsy: Parent Experiences

Journal of Child Neurology

Alam, A. and Parfyonov, M. and Huang, C.Y. and Gill, I. and Connolly, M.B. and Illes, J.

DOI: 10.1177/08830738221113901

Effect of Training on Visual Identification of High Frequency Oscillations"A Delphi-Style Intervention

Frontiers in Neurology

Spring, A.M. and Pittman, D.J. and Rizwan, A. and Aghakhani, Y. and Jirsch, J. and Connolly, M. and Wiebe, S. and Appendino, J.P. and Datta, A. and Steve, T. and Pillay, N. and Javidan, M. and Scantlebury, M. and Hrazdil, C. and Josephson, C.B. and Boelman, C. and Gross, D. and Singh, S. and Bello-Espinosa, L. and Huh, L. and Jett, N. and Federico, P.

DOI: 10.3389/fneur.2022.794668

Adults with tuberous sclerosis complex: A distinct patient population

Epilepsia

Bachour, K. and House, A.A. and Andrade, D.M. and Connolly, M. and Debicki, D.B. and Desbiens, R. and Fantaneanu, T.A. and Kyriakopoulos, P. and Lattouf, J.-B. and Suller-Marti, A. and Marques, P. and Keezer, M.R.

DOI: 10.1111/epi.17159

Clinician preferences for neurotechnologies in pediatric drug-resistant epilepsy: A discrete choice experiment

Epilepsia

Apantaku, G.O. and McDonald, P.J. and Aguiar, M. and Cabrera, L.Y. and Chiong, W. and Connolly, M.B. and Hrincu, V. and Ibrahim, G.M. and Kaal, K.J. and Lawson, A. and Naftel, R. and Racine, E. and Safari, A. and Harrison, M. and Illes, J.

DOI: 10.1111/epi.17328

Cognitive outcome in children with infantile spasms using a standardized treatment protocol. A five-year longitudinal study

Seizure

Bitton, J.Y. and Desnous, B. and Sauerwein, H.C. and Connolly, M. and Weiss, S.K. and Donner, E.J. and Whiting, S. and Mohamed, I.S. and Wirrell, E.C. and Ronen, G.M. and Lortie, A.

DOI: 10.1016/j.seizure.2021.04.027

Seizure action plans in the pediatric population with epilepsy: Uptake, determinants, and parental interest in a mobile application

Epilepsy and Behavior

Chiu, M. and Peinhof, S. and De Guzman, C. and Borhani, M. and Siu, C. and Kuzeljevic, B. and Schrader, D. and Huh, L. and Connolly, M.B.

DOI: 10.1016/j.yebeh.2021.107860

Choice and Trade-offs: Parent Decision Making for Neurotechnologies for Pediatric Drug-Resistant Epilepsy

Journal of Child Neurology

Hrincu, V. and McDonald, P.J. and Connolly, M.B. and Harrison, M.J. and Ibrahim, G.M. and Naftel, R.P. and Chiong, W. and Alam, A. and Ribary, U. and Illes, J.

DOI: 10.1177/08830738211015010

Rapid Implementation of Virtual Health in a Pediatric Neurology Practice during COVID-19

Canadian Journal of Neurological Sciences

Lee, J. and Schrader, D. and Boelman, C. and Huh, L. and Connolly, M.B.

DOI: 10.1017/cjn.2020.241

SETD1B -associated neurodevelopmental disorder

Journal of Medical Genetics

Roston, A. and Evans, D. and Gill, H. and McKinnon, M. and Isidor, B. and Cogn, B. and Mwenifumbo, J. and Van Karnebeek, C. and An, J. and Jones, S.J.M. and Farrer, M. and Demos, M. and Connolly, M. and Gibson, W.T.

DOI: 10.1136/jmedgenet-2019-106756

Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study

Epilepsia

Fallah, A. and Lewis, E. and Ibrahim, G.M. and Kola, O. and Tseng, C.-H. and Harris, W.B. and Chen, J.-S. and Lin, K.-M. and Cai, L.-X. and Liu, Q.-Z. and Lin, J.-L. and Zhou, W.-J. and Mathern, G.W. and Smyth, M.D. and O'Neill, B.R. and Dudley, R.W.R. and Ragheb, J. and Bhatia, S. and Delev, D. and Ramantani, G. and Zentner, J. and Wang, A.C. and Dorfer, C. and Feucht, M. and Czech, T. and Bollo, R.J. and Issabekov, G. and Zhu, H. and Connolly, M. and Steinbok, P. and Zhang, J.-G. and Zhang, K. and Hidalgo, E.T. and Weiner, H.L. and Wong-Kisiel, L. and Lapalme-Remis, S. and Tripathi, M. and Sarat Chandra, P. and Hader, W. and Wang, F.-P. and Yao, Y. and Champagne, P.-O. and Brunette-Clment, T. and Guo, Q. and Li, S.-C. and Budke, M. and Prez-Jimnez, M.A. and Raftopoulos, C. and Finet, P. and Michel, P. and Schaller, K. and Stienen, M.N. and Baro, V. and Cantillano Malone, C. and Pociecha, J. and Chamorro, N. and Muro, V.L. and von Lehe, M. and Vieker, S. and Oluigbo, C. and Gaillard, W.D. and Al-Khateeb, M. and Al Otaibi, F. and Krayenbhl, N. and Bolton, J. and Pearl, P.L. and Weil, A.G.

DOI: 10.1111/epi.17021

Longitudinal changes in emotional functioning following pediatric resective epilepsy surgery: 2-Year follow-up.

Epilepsy & behavior : E&B

Phillips NL and Widjaja E and Speechley K and Ferro M and Connolly M and Major P and Gallagher A and Ramachandrannair R and Almubarak S and Hasal S and Andrade A and Xu Q and Leung E and Smith ML

DOI: 10.1016/j.yebeh.2020.107585 PubMed: 33272893

11 / 2020

Novel Neurotechnological Interventions for Pediatric Drug-Resistant Epilepsy: Physician Perspectives.

Journal of child neurology

McDonald PJ and Hrincu V and Connolly MB and Harrison MJ and Ibrahim GM and Naftel RP and Chiong W and Udwadia F and Illes J

DOI: 10.1177/0883073820966935 PubMed: 33111593

10 / 2020

Youth Weigh In: Views on Advanced Neurotechnology for Drug-Resistant Epilepsy.

Journal of child neurology

Udwadia FR and McDonald PJ and Connolly MB and Hrincu V and Illes J

DOI: 10.1177/0883073820957810 PubMed: 32942941

09 / 2020

Ethically Problematic Medical Device Representation.

The American journal of bioethics : AJOB

Illes J and McDonald PJ and Lau C and Hrincu VM and Connolly MB

DOI: 10.1080/15265161.2020.1782643 PubMed: 32757913

08 / 2020

Erratum: Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy (Molecular Brain (2019) 12 (92) DOI: 10.1186/s13041-019-0513-9)

Molecular Brain

Bai, Y.-F. and Chiu, M. and Chan, E.S. and Axerio-Cilies, P. and Lu, J. and Huh, L. and Connolly, M.B. and Guella, I. and Farrer, M.J. and Xu, Z.-Q.D. and Liu, L. and Demos, M. and Wang, Y.T.

DOI: 10.1186/s13041-020-00593-6

Seizure freedom improves health-related quality of life after epilepsy surgery in children

Developmental Medicine and Child Neurology

Jain, P. and Smith, M.L. and Speechley, K. and Ferro, M. and Connolly, M. and Ramachandrannair, R. and Almubarak, S. and Andrade, A. and Widjaja, E.

DOI: 10.1111/dmcn.14390

Assessing an Interactive Online Tool to Support Parents' Genomic Testing Decisions

Journal of Genetic Counseling

Adam, S. and Birch, P.H. and Coe, R.R. and Bansback, N. and Jones, A.L. and Connolly, M.B. and Demos, M.K. and Toyota, E.B. and Farrer, M.J. and Friedman, J.M.

DOI: 10.1007/s10897-018-0281-1

Exome sequencing identified a de novo mutation of PURA gene in a patient with familial Xp22.31 microduplication

European Journal of Medical Genetics

Qiao, Y. and Bagheri, H. and Tang, F. and Badduke, C. and Martell, S. and Lewis, S.M.E. and Robinson, W. and Connolly, M.B. and Arbour, L. and Rajcan-Separovic, E.

DOI: 10.1016/j.ejmg.2018.06.010

mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report

Journal of Child Neurology

Xu, Q. and Uliel-Sibony, S. and Dunham, C. and Sarnat, H. and Flores-Sarnat, L. and Brunga, L. and Davidson, S. and Lo, W. and Shlien, A. and Connolly, M. and Boelman, C. and Datta, A.

DOI: 10.1177/0883073818813238

CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines

Breast Cancer Research and Treatment

Drgemller, B.I. and Wright, G.E.B. and Shih, J. and Monzon, J.G. and Gelmon, K.A. and Ross, C.J.D. and Amstutz, U. and Carleton, B.C. and Chang, W.C. and Connolly, M.B. and Dionne, F. and Groeneweg, G. and Loucks, C.M. and MacLeod, S.M. and Pritchard, S. and Rassekh, S.R. and Sanatani, S. and Tanoshima, R. and Virani, S.A. and Monzon, J.G. and Bhavsar, A.P. and Rieder, M.J. and Shear, N.H. and Liu, G. and Khayat, P. and Bernstein, D. and Lesko, L.J. and Aminkeng, F.

DOI: 10.1007/s10549-018-5027-0

Atypical cerebral palsy: genomics analysis enables precision medicine

Genetics in Medicine

Matthews, A.M. and Blydt-Hansen, I. and Al-Jabri, B. and Andersen, J. and Tarailo-Graovac, M. and Price, M. and Selby, K. and Demos, M. and Connolly, M. and Drgemoller, B. and Shyr, C. and Mwenifumbo, J. and Elliott, A.M. and Lee, J. and Ghani, A. and Stckler, S. and Salvarinova, R. and Vallance, H. and Sinclair, G. and Ross, C.J. and Wasserman, W.W. and McKinnon, M.L. and Horvath, G.A. and Goez, H. and van Karnebeek, C.D.

DOI: 10.1038/s41436-018-0376-y

Position Statement on the Use of Medical Cannabis for the Treatment of Epilepsy in Canada,nonc de position quant l'utilisation du cannabis mdical dans le traitement de l'pilepsie

Canadian Journal of Neurological Sciences

Appendino, J.P. and Boelman, C. and Brna, P.M. and Burneo, J.G. and Claassen, C.S. and Connolly, M.B. and De Guzman, M.V.T. and Federico, P. and Floyd, D. and Huntsman, R.J. and Javidan, M. and Jette, N. and Jurasek, L.L. and Keezer, M.R. and Lau, J.C. and McCoy, B. and McLachlan, R.S. and Ng, M.C. and Nguyen, D.K. and Reid, A.Y. and Rho, J.M. and Snead, O.C. and Tllez-Zenteno, J.F. and Wang, L. and Zak, M.M.

DOI: 10.1017/cjn.2019.282

Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy

Molecular Brain

Bai, Y.-F. and Chiu, M. and Chan, E.S. and Axerio-Cilies, P. and Lu, J. and Huh, L. and Connolly, M.B. and Guella, I. and Farrer, M.J. and Xu, Z.-Q.D. and Liu, L. and Demos, M. and Wang, Y.T.

DOI: 10.1186/s13041-019-0513-9

Care-related quality of life in caregivers of children with drug-resistant epilepsy

Journal of Neurology

Jain, P. and Subendran, J. and Smith, M.L. and Widjaja, E. and Carter Snead, O. and Go, C. and Connolly, M. and Ramachandrannair, R. and Carmant, L. and Speechley, K. and Andrade, A. and Ferro, M. and Bello-Espinosa, L. and Xu, Q. and Leung, E. and Almubarak, S. and Brna, P.

DOI: 10.1007/s00415-018-8979-4

Humanized mouse model of Rasmussen's encephalitis supports the immune-mediated hypothesis

Journal of Clinical Investigation

Kebir, H. and Carmant, L. and Fontaine, F. and Bland, K. and Bosoi, C.M. and Sanon, N.T. and Alvarez, J.I. and Desgent, S. and Pittet, C.L. and Hbert, D. and Langlois, M.-J. and Rbillard, R.-M. and Nguyen, D.K. and Cieuta-Walti, C. and Holmes, G.L. and Goodkin, H.P. and Mytinger, J.R. and Connolly, M.B. and Prat, A. and Haddad, E.

DOI: 10.1172/JCI97098

MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study

The Lancet Child and Adolescent Health

Fadda, G. and Brown, R.A. and Longoni, G. and Castro, D.A. and O'Mahony, J. and Verhey, L.H. and Branson, H.M. and Waters, P. and Bar-Or, A. and Marrie, R.A. and Yeh, E.A. and Narayanan, S. and Arnold, D.L. and Banwell, B. and Wambera, K. and Connolly, M.B. and Yager, J. and Mah, J.K. and Sebire, G. and Callen, D. and Meaney, B. and Dilenge, M.-E. and Lortie, A. and Pohl, D. and Doja, A. and Venkateswaran, S. and Levin, S. and MacDonald, E.A. and Meek, D. and Wood, E. and Buckley, D. and Awuku, M. and Baird, J.B. and Bhan, V. and Arnaoutelis, R. and Nandamalavan, D.

DOI: 10.1016/S2352-4642(18)30026-9

Improvement of Self-Injury With Dopamine and Serotonin Replacement Therapy in a Patient With a Hemizygous PAK3 Mutation: A New Therapeutic Strategy for Neuropsychiatric Features of an Intellectual Disability Syndrome

Journal of Child Neurology

Horvath, G.A. and Tarailo-Graovac, M. and Bartel, T. and Race, S. and Van Allen, M.I. and Blydt-Hansen, I. and Ross, C.J. and Wasserman, W.W. and Connolly, M.B. and van Karnebeek, C.D.M.

DOI: 10.1177/0883073817740443

Secondary Abnormal CSF Neurotransmitter Metabolite Profiles in a Pediatric Tertiary Care Centre

Canadian Journal of Neurological Sciences

Van Karnebeek, C.D.M. and Dunbar, M. and Egri, C. and Sayson, B. and Milea, J. and Stockler-Ipsiroglu, S. and Huh, L. and Connolly, M.B. and Horvath, G.A.

DOI: 10.1017/cjn.2017.271

ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology,ILAE-Klassifikation der Epilepsien: Positionspapier derILAE-Kommission fr Klassifikation und Terminologie

Zeitschrift fur Epileptologie

Scheffer, I.E. and Berkovic, S. and Capovilla, G. and Connolly, M.B. and French, J. and Guilhoto, L. and Hirsch, E. and Jain, S. and Mathern, G.W. and Mosh, S.L. and Nordli, D.R. and Perucca, E. and Tomson, T. and Wiebe, S. and Zhang, Y.-H. and Zuberi, S.M.

DOI: 10.1007/s10309-018-0218-6

An Infant With Epilepsy and Recurrent Hemiplegia due to Compound Heterozygous Variants in ATP1A2

Pediatric Neurology

Wilbur, C. and Buerki, S.E. and Guella, I. and Toyota, E.B. and Evans, D.M. and McKenzie, M.B. and Datta, A. and Michoulas, A. and Adam, S. and Van Allen, M.I. and Nelson, T.N. and Farrer, M.J. and Connolly, M.B. and Demos, M.

DOI: 10.1016/j.pediatrneurol.2017.06.003

De Novo Mutations in YWHAG Cause Early-Onset Epilepsy

American Journal of Human Genetics

Guella, I. and McKenzie, M.B. and Evans, D.M. and Buerki, S.E. and Toyota, E.B. and Van Allen, M.I. and Adam, S. and Boelman, C. and Bolbocean, C. and Candido, T. and Eydoux, P. and Horvath, G. and Huh, L. and Nelson, T.N. and Sinclair, G. and van Karnebeek, C. and Vercauteren, S. and Suri, M. and Elmslie, F. and Simon, M.E.H. and van Gassen, K.L.I. and Hron, D. and Keren, B. and Nava, C. and Connolly, M.B. and Demos, M. and Farrer, M.J.

DOI: 10.1016/j.ajhg.2017.07.004

Manifestations of Tuberous Sclerosis Complex: The Experience of a Provincial Clinic

Canadian Journal of Neurological Sciences

Wilbur, C. and Sanguansermsri, C. and Chable, H. and Anghelina, M. and Peinhof, S. and Anderson, K. and Steinbok, P. and Singhal, A. and Datta, A. and Connolly, M.B.

DOI: 10.1017/cjn.2016.311

The relationship between d-beta-hydroxybutyrate blood concentrations and seizure control in children treated with the ketogenic diet for medically intractable epilepsy

Epilepsia Open

Buchhalter, J.R. and D'Alfonso, S. and Connolly, M. and Fung, E. and Michoulas, A. and Sinasac, D. and Singer, R. and Smith, J. and Singh, N. and Rho, J.M.

DOI: 10.1002/epi4.12058

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

Epilepsia

Scheffer, I.E. and Berkovic, S. and Capovilla, G. and Connolly, M.B. and French, J. and Guilhoto, L. and Hirsch, E. and Jain, S. and Mathern, G.W. and Mosh, S.L. and Nordli, D.R. and Perucca, E. and Tomson, T. and Wiebe, S. and Zhang, Y.-H. and Zuberi, S.M.

DOI: 10.1111/epi.13709

Child- and parent-reported quality of life trajectories in children with epilepsy: A prospective cohort study

Epilepsia

Ferro, M.A. and Avery, L. and Fayed, N. and Streiner, D.L. and Cunningham, C.E. and Boyle, M.H. and Lach, L. and Glidden, G. and Rosenbaum, P.L. and Ronen, G.M. and Connolly, M. and Bello-Espinosa, L. and Rafay, M.F. and Appendino, J.P. and Shevell, M. and Carmant, L.

DOI: 10.1111/epi.13774

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy

American Journal of Human Genetics

Lehman, A. and Thouta, S. and Mancini, G.M.S. and Naidu, S. and van Slegtenhorst, M. and McWalter, K. and Person, R. and Mwenifumbo, J. and Salvarinova, R. and Adam, S. and du Souich, C. and Elliott, A.M. and Nelson, T.N. and van Karnebeek, C. and Friedman, J.M. and Boelman, C. and Bolbocean, C. and Buerki, S.E. and Candido, T. and Eydoux, P. and Evans, D.M. and Gibson, W. and Horvath, G. and Huh, L. and Sinclair, G. and Tarling, T. and Toyota, E.B. and Townsend, K.N. and Van Allen, M.I. and Vercauteren, S. and Guella, I. and McKenzie, M.B. and Datta, A. and Connolly, M.B. and Kalkhoran, S.M. and Poburko, D. and Farrer, M.J. and Demos, M. and Desai, S. and Claydon, T.

DOI: 10.1016/j.ajhg.2017.05.016

Clinical, imaging, and immunohistochemical characteristics of focal cortical dysplasia Type II extratemporal epilepsies in children: Analyses of an institutional case series

Journal of Neurosurgery: Pediatrics

Knerlich-Lukoschus, F. and Connolly, M.B. and Hendson, G. and Steinbok, P. and Dunham, C.

DOI: 10.3171/2016.8.PEDS1686

Clinical Experience with Perampanel for Refractory Pediatric Epilepsy in One Canadian Center

Journal of Child Neurology

Datta, A.N. and Xu, Q. and Sachedina, S. and Boelman, C. and Huh, L. and Connolly, M.B.

DOI: 10.1177/0883073817709195

Correlates of health-related quality of life in children with drug resistant epilepsy

Epilepsia

Lauryn Conway and Mary Lou Smith and Mark A. Ferro and Kathy N. Speechley and Mary B. Connoly and O. Carter Snead and Elysa Widjaja and the PEPSQOL Study Team

DOI: 10.1111/epi.13441

06 / 2016

Exome sequencing and the management of neurometabolic disorders

New England Journal of Medicine

Tarailo-Graovac, M. and Shyr, C. and Ross, C.J. and Horvath, G.A. and Salvarinova, R. and Ye, X.C. and Zhang, L.-H. and Bhavsar, A.P. and Lee, J.J.Y. and Drgemller, B.I. and Abdelsayed, M. and Alfadhel, M. and Armstrong, L. and Baumgartner, M.R. and Burda, P. and Connolly, M.B. and Cameron, J. and Demos, M. and Dewan, T. and Dionne, J. and Evans, A.M. and Friedman, J.M. and Garber, I. and Lewis, S. and Ling, J. and Mandal, R. and Mattman, A. and McKinnon, M. and Michoulas, A. and Metzger, D. and Ogunbayo, O.A. and Rakic, B. and Rozmus, J. and Ruben, P. and Sayson, B. and Santra, S. and Schultz, K.R. and Selby, K. and Shekel, P. and Sirrs, S. and Skrypnyk, C. and Superti-Furga, A. and Turvey, S.E. and Van Allen, M.I. and Wishart, D. and Wu, J. and Wu, J. and Zafeiriou, D. and Kluijtmans, L. and Wevers, R.A. and Eydoux, P. and Lehman, A.M. and Vallance, H. and Stockler-Ipsiroglu, S. and Sinclair, G. and Wasserman, W.W. and Van Karnebeek, C.D.

DOI: 10.1056/NEJMoa1515792

De novo FGF12 mutation in 2 patients with neonatal-onset epilepsy

Neurology: Genetics

Guella, I. and Huh, L. and McKenzie, M.B. and Toyota, E.B. and Martina Bebin, E. and Thompson, M.L. and Cooper, G.M. and Evans, D.M. and Buerki, S.E. and Adam, S. and Van Allen, M.I. and Nelson, T.N. and Connolly, M.B. and Farrer, M.J. and Demos, M.

DOI: 10.1212/NXG.0000000000000120

Dravet Syndrome: Diagnosis and Long-Term Course

Canadian Journal of Neurological Sciences

Connolly, M.B.

DOI: 10.1017/cjn.2016.243

Children's perspective of quality of life in epilepsy

Neurology

N. Fayed and A. M. Davis and D. L. Streiner and P. L. Rosenbaum and C. E. Cunningham and L. M. Lach and M. H. Boyle and G. M. Ronen and On behalf of the QUALITE Study Group

DOI: 10.1212/wnl.0000000000001536

04 / 2015

Recovery from central nervous system acute demyelination in children

Pediatrics

O'Mahony, J. and Marrie, R.A. and Laporte, A. and Yeh, E.A. and Bar-Or, A. and Phan, C. and Buckley, D. and Callen, D. and Connolly, M.B. and Pohl, D. and Dilenge, M.-E. and Bernard, G. and Lortie, A. and Lowry, N. and MacDonald, E.A. and Meek, D. and Sbire, G. and Venkateswaran, S. and Wood, E. and Yager, J. and Banwell, B.

DOI: 10.1542/peds.2015-0028

Resective Epilepsy Surgery for Tuberous Sclerosis in Children: Determining Predictors of Seizure Outcomes in a Multicenter Retrospective Cohort Study

Neurosurgery

Fallah, A. and Rodgers, S.D. and Weil, A.G. and Vadera, S. and Mansouri, A. and Connolly, M.B. and Major, P. and Ma, T. and Devinsky, O. and Weiner, H.L. and Gonzalez-Martinez, J.A. and Bingaman, W.E. and Najm, I. and Gupta, A. and Ragheb, J. and Bhatia, S. and Steinbok, P. and Witiw, C.D. and Widjaja, E. and Snead, O.C. and Rutka, J.T.

DOI: 10.1227/NEU.0000000000000875

The importance of cerebral magnetic resonance imaging in evaluation of neonatal seizures

Developmental Medicine and Child Neurology

Buerki, S.E. and Connolly, M.B.

DOI: 10.1111/dmcn.12640

The "vagal ansa": A source of complication in vagus nerve stimulation

Journal of Neurosurgery: Pediatrics

Gopalakrishnan, C.V. and Kestle, J.R.W. and Connolly, M.B.

DOI: 10.3171/2014.10.PEDS14259

Does treatment have an impact on incidence and risk factors for autism spectrum disorders in children with infantile spasms?

Epilepsia

Bitton, J.Y. and Demos, M. and Elkouby, K. and Connolly, M. and Weiss, S.K. and Donner, E.J. and Whiting, S. and Ronen, G.M. and Bello-Espinosa, L. and Wirrell, E.C. and Mohamed, I.S. and Dooley, J.M. and Carmant, L.

DOI: 10.1111/epi.12997

Clinical and magnetic resonance imaging (MRI) distinctions between tumefactive demyelination and brain tumors in children.

Journal of child neurology

Yiu EM and Laughlin S and Verhey LH and Banwell BL and Canadian Pediatric Demyelinating Disease Network

DOI: 10.1177/0883073813500713 PubMed: 24092896

05 / 2014

Diagnostic value of a multidisciplinary clinic for intellectual disability.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

van Karnebeek C and Murphy T and Giannasi W and Thomas M and Connolly M and Stockler-Ipsiroglu S

PubMed: 24718818

05 / 2014

Outcomes trajectories in children with epilepsy: hypotheses and methodology of a Canadian longitudinal observational study.

Pediatric neurology

Ronen GM and Streiner DL and Boyle MH and Cunningham CE and Lach L and Verhey LH and Fayed N and Chen K and Rosenbaum PL and QUALIT Group and Connolly M and Bello-Espinosa LE and Carmant L

DOI: 10.1016/j.pediatrneurol.2013.08.024 PubMed: 24370172

01 / 2014

Diagnostic Value of a Multidisciplinary Clinic for Intellectual Disability

Canadian Journal of Neurological Sciences

Van Karnebeek, C. and Murphy, T. and Giannasi, W. and Thomas, M. and Connolly, M. and Stockler-Ipsiroglu, S.

DOI: 10.1017/S0317167100017273

Pyridoxine responsiveness in novel mutations of the PNPO gene

Neurology

Plecko, B. and Paul, K. and Mills, P. and Clayton, P. and Paschke, E. and Maier, O. and Hasselmann, O. and Schmiedel, G. and Kanz, S. and Connolly, M. and Wolf, N. and Struys, E. and Stockler, S. and Abela, L. and Hofer, D.

DOI: 10.1212/WNL.0000000000000344

Acute flaccid paralysis in a child infected with enterovirus D68: A case report

British Columbia Medical Journal

Sherwood, M.D. and Gantt, S. and Connolly, M. and Dobson, S.

Recommendations for HLA-B15:02 and HLA-A31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions

Epilepsia

Amstutz, U. and Shear, N.H. and Rieder, M.J. and Hwang, S. and Fung, V. and Nakamura, H. and Connolly, M.B. and Ito, S. and Carleton, B.C.

DOI: 10.1111/epi.12564

Classifying Epileptic Seizures and the Epilepsies

Epilepsy

Muro, V.M. and Connolly, M.B.

DOI: 10.1002/9781118456989.ch2

Masquerades of acquired demyelination in children: experiences of a national demyelinating disease program.

Journal of child neurology

O'Mahony J and Bar-Or A and Arnold DL and Sadovnick AD and Marrie RA and Banwell B and Canadian Pediatric Demyelinating Disease Network

DOI: 10.1177/0883073812443006 PubMed: 22573735

02 / 2013

A condensed performance-validation strategy for multiplex detection kits used in studies of human clinical samples

Journal of Immunological Methods

Chahrazed Belabani and Sathyanath Rajasekharan and Viviane Poupon and Trina Johnson and Amit Bar-Or

DOI: 10.1016/j.jim.2012.08.002

01 / 2013

Hippocampal malrotation and temporal lobe epilepsy: What is the relationship?

Canadian Journal of Neurological Sciences

Connolly, M.B.

DOI: 10.1017/S0317167100014839 PubMed: 23968933

A case report of obsessive-compulsive disorder following acute disseminated encephalomyelitis

Pediatrics

Muir, K.E. and McKenney, K.S. and Connolly, M.B. and Evelyn Stewart, S.

DOI: 10.1542/peds.2012-2876

MRI findings in infants with infantile spasms after neonatal hypoxic-ischemic encephalopathy

Pediatric Neurology

Gano, D. and Sargent, M.A. and Miller, S.P. and Connolly, M.B. and Wong, P. and Glass, H.C. and Poskitt, K.J. and Chau, V.

DOI: 10.1016/j.pediatrneurol.2013.08.007

Status epilepticus amauroticus and posterior reversible encephalopathy syndrome in children

Journal of Clinical Neurophysiology

Muro, V.L. and Yip, S. and Huh, L. and Connolly, M.B.

DOI: 10.1097/WNP.0b013e31829de004

Discontinuation of antiepileptic drugs after successful epilepsy surgery. a Canadian survey.

Epilepsy research

Tllez-Zenteno JF and Ronquillo LH and Jette N and Burneo JG and Nguyen DK and Donner EJ and Sadler M and Javidan M M and Gross DW and Wiebe S and Canadian Epilepsy Surgery Study Group

DOI: 10.1016/j.eplepsyres.2012.04.018 PubMed: 22595484

11 / 2012

Benign myoclonic epilepsy of infancy

Pediatric Epilepsy

Connolly MB. Benign myoclonic epilepsy of infancy. In: Pediatric Epilepsy, 1st Edition. Cross H, Duchowny M, Glauser T, Hirsch E, Arzimanoglou A. McGraw-Hill, London. ISBN: 9780071496216 / 0071496211. August 2012.

08 / 2012

2010 McDonald criteria for diagnosing pediatric multiple sclerosis

Annals of Neurology

Yair Sadaka and Leonard H. Verhey and Manohar M. Shroff and Helen M. Branson and Douglas L. Arnold and Sridar Narayanan and John G. Sled and Amit Bar-Or and A. Dessa Sadovnick and Melissa McGowan and Ruth Ann Marrie and Brenda Banwell and on behalf of the Canadian Pediatric Demyelinating Disease Network

DOI: 10.1002/ana.23575

08 / 2012

Epilepsy surgery in childhood

Canadian Journal of Neurological Sciences

Muro, V.L. and Connolly, M.B.

DOI: 10.1017/s0317167100018163

Lysine restricted diet for pyridoxine-dependent epilepsy: First evidence and future trials

Molecular Genetics and Metabolism

van Karnebeek, C.D.M. and Hartmann, H. and Jaggumantri, S. and Bok, L.A. and Cheng, B. and Connolly, M. and Coughlin, C.R. and Das, A.M. and Gospe, S.M. and Jakobs, C. and van der Lee, J.H. and Mercimek-Mahmutoglu, S. and Meyer, U. and Struys, E. and Sinclair, G. and Van Hove, J. and Collet, J.-P. and Plecko, B.R. and Stockler, S.

DOI: 10.1016/j.ymgme.2012.09.006

Profound neonatal hypoglycemia and lactic acidosis caused by pyridoxine-dependent epilepsy

Pediatrics

Mercimek-Mahmutoglu, S. and Horvath, G.A. and Coulter-Mackie, M. and Nelson, T. and Waters, P.J. and Sargent, M. and Struys, E. and Jakobs, C. and Stockler-Ipsiroglu, S. and Connolly, M.B.

DOI: 10.1542/peds.2011-0123

Systematic review and case series of neuropsychological functioning after epilepsy surgery in children with dysembryoplastic neuroepithelial tumors (DNET)

Epilepsy and Behavior

Fay-McClymont, T.B. and Hrabok, M. and Sherman, E.M.S. and Hader, W.J. and Connolly, M.B. and Akdag, S. and Mohamed, I.S. and Wiebe, S.

DOI: 10.1016/j.yebeh.2011.12.011

Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination.

Neurology

Venkateswaran S and Zheng K and Sacchetti M and Gagne D and Arnold DL and Sadovnick AD and Scherer SW and Banwell B and Bar-Or A and Simon DK and Canadian Pediatric Demyelinating Disease Network

DOI: 10.1212/wnl.0b013e31820ee1bb PubMed: 21288980

03 / 2011

HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination.

Neurology

Disanto G and Magalhaes S and Handel AE and Morrison KM and Sadovnick AD and Ebers GC and Banwell B and Bar-Or A and Canadian Pediatric Demyelinating Disease Network

DOI: 10.1212/wnl.0b013e31820ee1cd PubMed: 21288988

03 / 2011

Approach to a child with a first afebrile seizure

British Columbia Medical Journal

Michoulas, A. and Farrell, K. and Connolly, M.

Electroclinical features of absence seizures in sleep

Epilepsy Research

Sadleir, L.G. and Farrell, K. and Smith, S. and Connolly, M.B. and Scheffer, I.E.

DOI: 10.1016/j.eplepsyres.2010.12.009

Landau-Kleffner syndrome: A rare Auditory Processing Disorder. Series of cases and review of the literature

International Journal of Pediatric Otorhinolaryngology

Fandio, M. and Connolly, M. and Usher, L. and Palm, S. and Kozak, F.K.

DOI: 10.1016/j.ijporl.2010.10.001

Improving the management of epilepsy in children

British Columbia Medical Journal

Farrell Dr., K. and Connolly Dr., M.

Cerebral sinus thrombosis following IV immunoglobulin therapy of immune thrombocytopenia purpura

Pediatric Blood and Cancer

Al-Riyami, A.Z. and Lee, J. and Connolly, M. and Shereck, E.

DOI: 10.1002/pbc.22968

Cerebrovasculopathy in NF1 associated with ocular and scalp defects

American Journal of Medical Genetics, Part A

Smith, M. and Heran, M.K. and Connolly, M.B. and Heran, H.K. and Friedman, J.M. and Jett, K. and Lyons, C.J. and Steinbok, P. and Armstrong, L.

DOI: 10.1002/ajmg.a.33788

Epilepsy with occipital features in children: Factors predicting seizure outcome and neuroimaging abnormalities

European Journal of Paediatric Neurology

Schrader, D. and Shukla, R. and Gatrill, R. and Farrell, K. and Connolly, M.

DOI: 10.1016/j.ejpn.2010.08.005

Electrocorticography and seizure outcomes in children with lesional epilepsy

Child's Nervous System

Gelinas, J.N. and Battison, A.W. and Smith, S. and Connolly, M.B. and Steinbok, P.

DOI: 10.1007/s00381-010-1279-7

Pyridoxine dependent epilepsy and antiquitin deficiency. Clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up

Molecular Genetics and Metabolism

Stockler, S. and Plecko, B. and Gospe, S.M. and Coulter-Mackie, M. and Connolly, M. and van Karnebeek, C. and Mercimek-Mahmutoglu, S. and Hartmann, H. and Scharer, G. and Struijs, E. and Tein, I. and Jakobs, C. and Clayton, P. and Van Hove, J.L.K.

DOI: 10.1016/j.ymgme.2011.05.014

Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: A prospective national cohort study

The Lancet Neurology

Banwell, B. and Bar-Or, A. and Arnold, D.L. and Sadovnick, D. and Narayanan, S. and McGowan, M. and O'Mahony, J. and Magalhaes, S. and Hanwell, H. and Vieth, R. and Tellier, R. and Vincent, T. and Disanto, G. and Ebers, G. and Wambera, K. and Connolly, M.B. and Yager, J. and Mah, J.K. and Booth, F. and Sebire, G. and Callen, D. and Meaney, B. and Dilenge, M.-E. and Lortie, A. and Pohl, D. and Doja, A. and Venketaswaran, S. and Levin, S. and MacDonald, E.A. and Meek, D. and Wood, E. and Lowry, N. and Buckley, D. and Yim, C. and Awuku, M. and Cooper, P. and Grand'Maison, F. and Baird, J.B. and Bhan, V. and Marrie, R.A.

DOI: 10.1016/S1474-4422(11)70045-X

Parents report more ADHD symptoms than do teachers in children with epilepsy

Epilepsy and Behavior

Sherman, E.M.S. and Brooks, B.L. and Akdag, S. and Connolly, M.B. and Wiebe, S.

DOI: 10.1016/j.yebeh.2010.08.015

Treatment of intractable epilepsy in a female with SLC6A8 deficiency

Molecular Genetics and Metabolism

Mercimek-Mahmutoglu, S. and Connolly, M.B. and Poskitt, K.J. and Horvath, G.A. and Lowry, N. and Salomons, G.S. and Casey, B. and Sinclair, G. and Davis, C. and Jakobs, C. and Stockler-Ipsiroglu, S.

DOI: 10.1016/j.ymgme.2010.08.016

Red reflex mimicking lens subluxation in a child undergoing orthokeratology

Eye

Wiwatwongwana, A. and Connolly, M.B. and Lyons, C.J.

DOI: 10.1038/eye.2009.46

Epilepsy and memory dysfunction.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Connolly MB

PubMed: 19760900

08 / 2009

Epilepsy surgery in the first 3 years of life: A Canadian survey

Epilepsia

Steinbok, P. and Gan, P.Y.C. and Connolly, M.B. and Carmant, L. and Barry Sinclair, D. and Rutka, J. and Griebel, R. and Aronyk, K. and Hader, W. and Ventureyra, E. and Atkinson, J.

DOI: 10.1111/j.1528-1167.2008.01992.x

Automatisms in absence seizures in children with idiopathic generalized epilepsy

Archives of Neurology

Sadleir, L.G. and Scheffer, I.E. and Smith, S. and Connolly, M.B. and Farrell, K.

DOI: 10.1001/archneurol.2009.108

Incidence of acquired demyelination of the CNS in Canadian children

Neurology

Banwell, B. and Kennedy, J. and Sadovnick, D. and Arnold, D.L. and Magalhaes, S. and Wambera, K. and Connolly, M.B. and Yager, J. and Mah, J.K. and Shah, N. and Sebire, G. and Meaney, B. and Dilenge, M.-E. and Lortie, A. and Whiting, S. and Doja, A. and Levin, S. and Macdonald, E.A. and Meek, D. and Wood, E. and Lowry, N. and Buckley, D. and Yim, C. and Awuku, M. and Guimond, C. and Cooper, P. and Grand'maison, F. and Baird, J.B. and Bhan, V. and Bar-Or, A.

DOI: 10.1212/01.wnl.0000339482.84392.bd

Cingulate lesions presenting with epileptic spasms

Journal of Clinical Neurophysiology

Schrader, D. and Langill, L. and Singhal, A. and Steinbok, P. and Connolly, M.B.

DOI: 10.1097/WNP.0b013e3181baaacf

Epilepsy and memory dysfunction

Canadian Journal of Neurological Sciences

Connolly, M.B.

Urgent, resective surgery for medically refractory, convulsive status epilepticus

European Journal of Paediatric Neurology

Schrader, D.V. and Steinbok, P. and Connolly, M.

DOI: 10.1016/j.ejpn.2008.01.011

EEG features of absence seizures in idiopathic generalized epilepsy: Impact of syndrome, age, and state

Epilepsia

Sadleir, L.G. and Scheffer, I.E. and Smith, S. and Carstensen, B. and Farrell, K. and Connolly, M.B.

DOI: 10.1111/j.1528-1167.2008.02001.x

Factors influencing clinical features of absence seizures

Epilepsia

Sadleir, L.G. and Scheffer, I.E. and Smith, S. and Carstensen, B. and Carlin, J. and Connolly, M.B. and Farrell, K.

DOI: 10.1111/j.1528-1167.2008.01708.x

Epilepsy associated with a cerebellar arachnoid cyst: Seizure control following fenestration of the cyst

Child's Nervous System

Gan, Y.C. and Connolly, M.B.C. and Steinbok, P.

DOI: 10.1007/s00381-007-0439-x

Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: Evidence of a phenotypic continuum between dominant and recessive forms

Molecular Genetics and Metabolism

Horvath, G.A. and Stockler-Ipsiroglu, S.G. and Salvarinova-Zivkovic, R. and Lillquist, Y.P. and Connolly, M. and Hyland, K. and Blau, N. and Rupar, T. and Waters, P.J.

DOI: 10.1016/j.ymgme.2008.01.003

Sociodemographic correlates of health-related quality of life in pediatric epilepsy

Epilepsy and Behavior

Sherman, E.M.S. and Griffiths, S.Y. and Akdag, S. and Connolly, M.B. and Slick, D.J. and Wiebe, S.

DOI: 10.1016/j.yebeh.2007.07.009

Quality of life and seizure outcome after vagus nerve stimulation in children with intractable epilepsy

Journal of Child Neurology

Sherman, E.M.S. and Connolly, M.B. and Slick, D.J. and Eyrl, K.L. and Steinbok, P. and Farrell, K.

DOI: 10.1177/0883073808315417

Tick paralysis: Presentation as a pure cerebellar syndrome

Journal of Pediatric Neurology

Alroughani, R. and Guilfoyle, J. and Connolly, M.B.

DOI: 10.1055/s-0035-1557486

The spectrum of SCN1A-related infantile epileptic encephalopathies

Brain

Harkin, L.A. and McMahon, J.M. and Iona, X. and Dibbens, L. and Pelekanos, J.T. and Zuberi, S.M. and Sadleir, L.G. and Andermann, E. and Gill, D. and Farrell, K. and Connolly, M. and Stanley, T. and Harbord, M. and Andermann, F. and Wang, J. and Batish, S.D. and Jones, J.G. and Seltzer, W.K. and Gardner, A. and Sutherland, G. and Berkovic, S.F. and Mulley, J.C. and Scheffer, I.E. and Abbott, K. and Andrews, I. and Appleton, B. and Bleasel, A. and Buchanan, N. and Burke, C. and Bye, A. and Camfield, C. and Camfield, P. and Chow, G. and Collins, K. and Cook, M. and Cross, J.H. and Crow, Y. and D'Agostino, M.D. and Delatycki, M. and Dunkley, C. and Fawke, J. and Ferrie, C. and Geraghty, M. and Graham, G. and Grattan-Smith, P. and Hallam, E. and Hamiwka, L. and Harding, A. and Harvey, S. and Hayman, M. and Hufton, I. and Humphries, P. and Jacob, P. and Jacquemard, R. and Jamison, D. and Jardine, P. and Jones, S. and Keene, D. and Kelley, K. and Ketteridge, D. and Kim, A. and Kivity, S. and Kneebone, C. and Kornberg, A. and Lamb, C. and Lander, C. and Lerman-Sagie, T. and Lev, D. and Leventer, R. and Mackay, M. and Malone, S. and Manson, J. and McLellan, A. and Moore, P. and Nagarajan, L. and Nash, M. and Nikanorova, M. and Nordli, D. and O'Regan, M. and Ouvrier, R. and Patel, J. and Pridmore, C. and Ramesh, V. and Reutens, D. and Rowe, P. and Shield, L. and Shillito, P. and Smith, L. and Spooner, C. and Wallace, G. and Watemberg, N. and Whitehouse, W. and Wirrell, E.

DOI: 10.1093/brain/awm002

Postsurgical health-related quality of life (HRQOL) in children following hemispherectomy for intractable epilepsy

Epilepsia

Griffiths, S.Y. and Sherman, E.M.S. and Slick, D.J. and Eyrl, K. and Connolly, M.B. and Steinbok, P.

DOI: 10.1111/j.1528-1167.2006.00966.x

Surgical outcome in tuberous sclerosis complex: A multicenter survey

Epilepsia

Madhavan, D. and Schaffer, S. and Yankovsky, A. and Arzimanoglou, A. and Renaldo, F. and Zaroff, C.M. and LaJoie, J. and Weiner, H.L. and Andermann, E. and Franz, D.N. and Leonard, J. and Connolly, M. and Cascino, G.D. and Devinsky, O.

DOI: 10.1111/j.1528-1167.2007.01112.x

ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy

Epilepsia

Sherman, E.M.S. and Slick, D.J. and Connolly, M.B. and Eyrl, K.L.

DOI: 10.1111/j.1528-1167.2007.01028.x

Hemispheric surgery in children with refractory epilepsy: Seizure outcome, complications, and adaptive function

Epilepsia

Basheer, S.N. and Connolly, M.B. and Lautzenhiser, A. and Sherman, E.M.S. and Hendson, G. and Steinbok, P.

DOI: 10.1111/j.1528-1167.2006.00909.x

Tuberous sclerosis complex: A review of the management of epilepsy with emphasis on surgical aspects

Child's Nervous System

Connolly, M.B. and Hendson, G. and Steinbok, P.

DOI: 10.1007/s00381-006-0130-7

Electroclinical features of absence seizures in childhood absence epilepsy

Neurology

Sadleir, L.G. and Farrell, K. and Smith, S. and Connolly, M.B. and Scheffer, I.E.

DOI: 10.1212/01.wnl.0000228257.60184.82

Pharmacological management of a youth with ADHD and a seizure disorder

Journal of the American Academy of Child and Adolescent Psychiatry

Gonzalez-Heydrich, J. and Weiss, M. and Connolly, M. and Wambera, K. and Jan, J.E. and Plioplys, S. and Dunn, D.W. and Kratochvil, C.J.

DOI: 10.1097/01.chi.0000240836.71361.39

Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patienst with bipolar disorder: Consensus and controversies

Bipolar Disorders, Supplement

Yatham, L.N. and Kennedy, S.H. and O'Donovan, C. and Parikh, S. and MacQueen, G. and McIntyre, R. and Sharma, V. and Silverstone, P. and Alda, M. and Baruch, P. and Beaullieu, S. and Daigneault, A. and Milev, R. and Young, L.T. and Ravindran, A. and Schaffer, A. and Connolly, M. and Gorman, C.P.

6-Pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia

Annals of Neurology

Demos, M.K. and Waters, P.J. and Vallance, H.D. and Lillquist, Y. and Makhseed, N. and Hyland, K. and Blau, N. and Connolly, M.B.

DOI: 10.1002/ana.20532

Rasmussen syndrome

Epilepsy in Children, 2E

Mary Connolly

DOI: 10.1201/b13560-30

02 / 2004

Epileptic syndromes with onset in middle childhood: Rasmussen syndrome

Epilepsy in Children 2e

Connolly, M.B. and Arrell, K.F.

Spasms in children with definite and probable mitochondrial disease

European Journal of Neurology

Sadleir, L.G. and Connolly, M.B. and Applegarth, D. and Hendson, G. and Clarke, L. and Rakshi, C. and Farrell, K.

DOI: 10.1046/j.1351-5101.2003.00724.x

Preserved Episodic Memory in Subcortical Band Heterotopia

Epilepsia

Janzen, L. and Sherman, E. and Langfitt, J. and Berg, M. and Connolly, M.

DOI: 10.1111/j.0013-9580.2004.53203.x

Neurophysiological investigations

Epilepsy in Children, 2E

Connolly, M.B. and Wong, P.K.H.

Reexamining the effects of epilepsy surgery on IQ in children: use of regression-based change scores.

Journal of the International Neuropsychological Society : JINS

Sherman E and Slick DJ and Connolly MB and Steinbok P and Martin R and Strauss E and Chelune GJ and Farrell K

PubMed: 14632247

09 / 2003

Electrical fields and recording techniques

Current Practice of Clinical Electroencephalography, 3rd Edition

Connolly MB, Sharborough F, Wong PK. Electrical fields and recording techniques. Current Practice of Clinical Electroencephalography. 3rd Edition, Ed. John S. Ebersole, TA Pedley. P 72-99, Raven Press, 2003.

Erratum: Melatonin does not trigger convulsions (Pediatrics and Child Health (2003)8:7(471))

Paediatrics and Child Health

Connolly, M.

Risperidone in acute and continuation treatment of mania

International Clinical Psychopharmacology

Yatham, L.N. and Binder, C. and Riccardelli, R. and Leblanc, J. and Connolly, M. and Kusumakar, V.

DOI: 10.1097/00004850-200307000-00005

Reexamining the effects of epilepsy surgery on IQ in children: Use of regression-based change scores

Journal of the International Neuropsychological Society

Sherman, E.M.S. and Slick, D.J. and Connolly, M.B. and Steinbok, P. and Martin, R. and Strauss, E. and Chelune, G.J. and Farrell, K.

DOI: 10.1017/S1355617703960085

Melatonin does not trigger convulsions

Pediatrics and Child Health

Jan JE, Freeman RD, Connolly MB. Melatonin does not trigger convulsions. Pediatrics and Child Health. 2003;8:471.

New antiepileptic drug therapies

Neurologic Clinics

Bergin, A.M. and Connolly, M.

DOI: 10.1016/S0733-8619(02)00017-8

Validity of three measures of health-related quality of life in children with intractable epilepsy

Epilepsia

Sherman, E.M.S. and Slick, D.J. and Connolly, M.B. and Steinbok, P. and Camfield, C. and Eyrl, K.L. and Massey, C. and Farrell, K.

DOI: 10.1046/j.1528-1157.2002.03602.x

Hyperventilation-induced high-amplitude rhythmic slowing with altered awareness: A video-EEG comparison with absence seizures

Epilepsia

Lum, L.M. and Connolly, M.B. and Farrell, K. and Wong, P.K.H.

DOI: 10.1046/j.1528-1157.2002.35101.x

Surgical resection for intractable epilepsy in "double cortex" syndrome yields inadequate results

Epilepsia

Bernasconi, A. and Martinez, V. and Rosa-Neto, P. and D'Agostino, D. and Bernasconi, N. and Berkovic, S. and MacKay, M. and Simon Harvey, A. and Palmini, A. and Costa Da Costa, J. and Paglioli, E. and Kim, H.I. and Connolly, M. and Olivier, A. and Dubeau, F. and Andermann, E. and Guerrini, R. and Whisler, W. and De Toledo-Morrell, L. and Morrell, F. and Andermann, F.

DOI: 10.1046/j.1528-1157.2001.39900.x

Temporal lobectomy in early childhood: The need for long-term follow-up

Journal of Child Neurology

Sotero de Menezes, M.A. and Connolly, M. and Bolanos, A. and Madsen, J. and Black, P.M. and Riviello, J.J.

DOI: 10.1177/088307380101600809

Postvaricella angiopathy: Report of a case with pathologic correlation

Pediatric Neurology

Hayman, M. and Hendson, G. and Poskitt, K.J. and Connolly, M.B.

DOI: 10.1016/S0887-8994(01)00272-7

Cortical visual impairment in children with infantile spasms

Journal of AAPOS

Giovanni Castano and Christopher J. Lyons and James E. Jan and Mary Connolly

DOI: 10.1067/mpa.2000.104483

06 / 2000

Editorial Comment

Child's Nervous System

P. Steinbok and M. Connolly

DOI: 10.1007/s003810050515

05 / 2000

Factors associated with behavioral and cognitive abnormalities in children receiving Topiramate

Pediatric Neurology

Gerber, P.E. and Hamiwka, L. and Connolly, M.B. and Farrell, K.

DOI: 10.1016/S0887-8994(99)00151-4

Cortical visual impairment in children with infantile spasms.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus

Castano, G. and Lyons, C.J. and Jan, J.E. and Connolly, M.

DOI: 10.1016/S1091-8531(00)70009-7

Psychological assessment and treatment of psychogenic symptoms in children and adolescents

Non-epileptic Seizures, 2nd Edition

Ho A, Ransby MJ, Farrell K, Connolly MB, Thornton N. Psychological assessment and treatment of psychogenic symptoms in children and adolescents. In: Non-epileptic Seizures, 2nd Edition, Ed. Gates J, Rowan J. Butterworth Heinemann, 2000.

Pediatric peri-insular hemispherotomy

Pediatric Neurosurgery

Kestle, J. and Connolly, M. and Cochrane, D.

DOI: 10.1159/000028896

Melatonin treatment of non-epileptic myoclonus in children

Developmental Medicine and Child Neurology

Jan, J.E. and Connolly, M.B.C. and Hamilton, D. and Freeman, R.D. and Laudon, M.

DOI: 10.1017/S0012162299000535

High resolution EEG & seizure localization

Neuroimage

Wong, P.K.H. and Bjornson, B. and Connolly, M. and Steinbok, P. and Young, S.A. and Giaschi, D. and Gregory, D. and Smith, S. and Lee, R. and Man, A. and Cochrane, D.

Non-invasive mapping of sensorimotor cortex in a child with a cavernous angioma: FMRI and high-resolution EEG compared with surgical mapping

NeuroImage

Bjornson, B. and Giaschi, D. and Cochrane, D. and Au Young, S. and Rootman, D. and Boden, C. and Connolly, M. and Poskitt, K. and Boyle, C. and Smith, S. and Akagemi, R. and Wong, P.K.H.

Acquired brachial-plexus neuropathy in the neonate: a rare presentation of late-onset group-B streptococcal osteomyelitis.

Developmental medicine and child neurology

Sadleir LG and Connolly MB

PubMed: 9698064

07 / 1998

Acquired brachial-plexus neuropathy in the neonate: A rare presentation of late-onset group-B streptococcal osteomyelitis

Developmental Medicine and Child Neurology

Sadleir, L.G. and Connolly, M.B.

Encephalopathy complicating henoch schonlein purpura: Reversible MRI changes

Pediatric Neurology

Woolfenden, A.R. and Hukin, J. and Poskitt, K.J. and Connolly, M.B.

DOI: 10.1016/S0887-8994(98)00027-7

Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy

Pediatric Neurology

Farrell, K. and Connolly, M.B. and Munn, R. and Peng, S. and MacWilliam, L.M.

DOI: 10.1016/S0887-8994(97)00010-6

Reengineering a home health care agency to achieve cost effectiveness

Home Health Care Management and Practice

Connolly, M.L.

DOI: 10.1177/108482239701000106

Home health care and burn care: An educational and economical program

Journal of Burn Care and Rehabilitation

Dattolo, J. and Trout, S. and Connolly, M.L.

DOI: 10.1097/00004630-199603000-00017

Alternating paroxysmal dystonia and hemiplegia in childhood as a symptom of basal ganglia disease

Journal of Neurology, Neurosurgery and Psychiatry

Hart, Y.M. and Tampieri, D. and Andermann, E. and Andermann, F. and Connolly, M. and Farrell, K.

DOI: 10.1136/jnnp.59.4.453

Seizures Involving the Supplementary Sensorimotor Area in Children: A Video-EEG Analysis

Epilepsia

Connolly, M.B. and Langill, L. and Wong, P.K.H. and Farrell, K.

DOI: 10.1111/j.1528-1157.1995.tb00962.x

Home care of the prostate cryosurgery patient.

Today"s OR nurse

Connolly, M.L. and Russell, M. and Reyna, C.

Biological bases of brain function and disease

Journal of Epilepsy

Mary Connolly

DOI: 10.1016/0896-6974(94)90039-6

01 / 1994

Cranial Neuropathy, Polyneuropathy and Thrombocytopenia with Epstein-Barr Virus Infection

Developmental Medicine & Child Neurology

Connolly, M. and Junker, A.K. and Chan, K.W. and Farrell, K.

DOI: 10.1111/j.1469-8749.1994.tb11797.x

Outpatient Video-EEG Monitoring in Children

Epilepsia

Connolly, M.B. and Wong, P.K.H. and Karim, Y. and Smith, S. and Farrell, K.

DOI: 10.1111/j.1528-1157.1994.tb02465.x

Epilepsy in infants and children

Conn's Current Therapy

Farrell K., Connolly MB. Epilepsy in infants and children. In: Conns Current Therapy, 1994 Edition. Ed. Rakel R.E. WB Saunders 1994; 852-862.

Rapid cycling in severely multidisabled children: A form of bipolar affective disorder?

Pediatric Neurology

Jan, J.E. and Abroms, I.F. and Freeman, R.D. and Brown, G.M. and Espezel, H. and Connolly, M.B.

DOI: 10.1016/0887-8994(94)90064-7

Intrapartum Asphyxia in Term and Postterm Infants

Obstetrical & Gynecological Survey

A HALLIGAN and M CONNOLLY and T CLARKE and R P GLEESON and M HOLOHAN and T MATTHEWS and M KING and M R N DARLING

DOI: 10.1097/00006254-199306000-00009

06 / 1993

Searching for Human Epilepsy Genes: A Progress Report

Brain Pathology

Leppert, M. and McMahon, W.M. and Quattlebaum, T.G. and Bjerre, I. and Zonana, J. and Shevell, M.I. and Andermann, E. and Rosales, T.O. and Ronen, G.M. and Connolly, M. and Anderson, V.E.

DOI: 10.1111/j.1750-3639.1993.tb00764.x

MRI in pseudotumour cerebri

Pediatric Neurology Briefs

Connolly MB, Farrell K, Flodmark O, Hill A. MRI in pseudotumour cerebri. Pediatr Neurol Briefs, 1993; 7:10.

Seizure characteristics in chromosome 20 benign familial neonatal convulsions

Neurology

Ronen, G.M. and Rosales, T.O. and Connolly, M. and Anderson, V.E. and Leppert, M.

Magnetic resonance imaging in pseudotumor cerebri.

Developmental medicine and child neurology

Connolly MB and Farrell K and Hill A and Flodmark O

PubMed: 1451939

12 / 1992

Letter to the editor: Rapid recovery from cortical visual impairment following correction of prolonged shunt malfunction

Archives of Neurology

Connolly MB, Jan JE, Cochrane DD. Letter to the editor: Rapid recovery from cortical visual impairment following correction of prolonged shunt malfunction. Arch Neurol 1992;49:1112.

MAGNETIC RESONANCE IMAGING IN PSEUDOTUMOR CEREBRI

Developmental Medicine & Child Neurology

Connolly, M.B. and Farrell, K. and Hill, A. and Flodmark, O.

DOI: 10.1111/j.1469-8749.1992.tb11422.x

Clinical features for prediction of survival in neonatal muscle disease

Pediatric Neurology

Connolly, M.B. and Roland, E.H. and Hill, A.

DOI: 10.1016/0887-8994(92)90367-8

Visual evoked potentials and intracranial pressure-reply

Archives of Neurology

Connolly, M.B. and Jan, J.E. and Cochrane, D.D.

DOI: 10.1001/archneur.1992.00530350021011

Rapid Recovery From Cortical Visual Impairment Following Correction of Prolonged Shunt Malfunction in Congenital Hydrocephalus

Archives of Neurology

Connolly, M.B. and Jan, J.E. and Cochrane, D.D.

DOI: 10.1001/archneur.1991.00530210082028

Hepatic dysfunction in Alstrom disease

American Journal of Medical Genetics

Connolly, M.B. and Jan, J.E. and Couch, R.M. and Wong, L.T.K. and Dimmick, J.E. and Rigg, J.M.

DOI: 10.1002/ajmg.1320400408

Intravenous immunoglobulin and pyridoxine"dependent seizures

Neurology

Connolly, M.B. and Jan, J.E. and Junker, A.K.

DOI: 10.1212/WNL.41.9.1524

An approach to the diagnosis and treatment of seizures in children

Canadian Journal of Pediatrics

Connolly MB, Farrell K. An approach to the diagnosis and treatment of seizures in children. Can J. Pediatr 1991;16-27.

Head shaking by visually impaired children: a voluntary neurovisual adaptation which can be confused with spasmus nutans.

Developmental medicine and child neurology

Jan JE and Groenveld M and Connolly MB

PubMed: 2286305

12 / 1990

Head Shaking By Visually Impaired Children: A Voluntary Neurovisual Adaptation Which Can Be Confused With Spasmus Nutans

Developmental Medicine & Child Neurology

Jan, J.E. and Groenveld, M. and Connolly, M.B.

DOI: 10.1111/j.1469-8749.1990.tb08524.x

Cost of neonatal intensive and special care

Irish Medical Journal

Connolly MB, Fox G, OConnor G, Clarke TA, Matthews TG. Cost of neonatal intensive and special care. Ir Med J. 1989 Feb;82(1):34-6.

02 / 1989

Organize your workday: For more effective discharge planning

Nursing

Connolly, M.L.

DOI: 10.1097/00152193-198107000-00015

Diagnostic Yield and Treatment Impact of Targeted Exome Sequencing in Early-onset Epilepsy

Michelle Demos and Ilaria Guella and Marna B. McKenzie and Sarah E. Buerki and Daniel M. Evans and Eric B. Toyota and Cyrus Boelman and Linda L. Huh and Anita Datta and Aspasia Michoulas and Kathryn Selby and Bruce H. Bjornson and Gabriella Horvath and Elena Lopez-Rangel and Clara DM van Karnebeek and Ramona Salvarinova and Erin Slade and Patrice Eydoux and Shelin Adam and Margot. I. Van Allen and Tanya N. Nelson and Corneliu Bolbocean and Mary B. Connolly and Matthew J. Farrer

DOI: 10.1101/139329

Acute psychiatric adverse events associated with Levetiracetam therapy in children with epilepsy

This study analyzes acute psychiatric adverse events (PAEs) in children receiving Levetiracetam, a new anti-epileptic drug. Predisposing factors such a personal or family history of psychiatric illness dosing schedules are reviewed. The aim is to identify risk factors and try to minimize PAEs on Levetiracetam.

Outcome Trajectories in Children with Epilepsy: What Factors are Important?

Our centre is participating in this multicentre study funded by CIHR. A variety of factors, both environmental and organic, influence the life quality outcomes in children with epilepsy. Our hypothesis that changes in children’s outcomes over time will be more strongly related to child and family psychosocial factors than to epilepsy-specific variables. The outcomes examined in this study include biomedical health and functional status (primarily mental health and intellectual abilities), academic achievement and participation. We will also measure the subjective experience of epilepsy with generic and condition-specific self- and proxy-reported ‘quality of life’ (HRQL) instruments.

Outcome following epilepsy surgery

Since the epilepsy surgery program was established, I have personally followed all children who have had surgery longitudinally from a clinical perspective. Neuropsychological and quality of life studies have been performed prior to surgery and on follow-up.

With colleagues in neurosurgery and neuropsychology, I have published several papers on long-term outcomes and quality of life following hemispheric surgery, surgery for tuberous sclerosis and vagus nerve stimulation. We also recently reported the a group of children with refractory status epilepticus who had urgent epilepsy surgery. A recent study of epilepsy surgery in the first 3 years of life across Canada, one of the largest series in young children in the literature, outlines the success in this group.

I am currently studying outcomes in children who had epilepsy surgery in the frontal lobe and assessing factors which may negatively affect the outcome. I am also studying the long-term outcome in children who had temporal lobe surgery and assessing outcomes and the influence of neuropsychiatric disorders such as depression, psychosis and anxiety on outcome.

Grants

2014-2022 Impact of Pediatric Epilepsy Surgery on Health-Related Quality of Life

2019 An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution as an Adjunctive Therapy for Seizures in Patients with Rare Seizure Disorders Such as Epileptic Encephalopathies Including Dravet Syndrome and Lennox- Gastaut Syndrome

2022-2023 An Open-Label n Study of XEN496 in Pediatric Subjects with KCNQ2 Developmental and Epileptic EncephalopathyExtensio

2022-2023 A Phase 3 Study of Adjunctive XEN496 in Pediatric Subjects with KCNQ2 Developmental and Epileptic Encephalopathy

2023-2026 A 20-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of EPX-100 (Clemizole Hydrochloride) as Adjunctive Therapy in Patients with Dravet Syndrome

Canadian Epilepsy Database and Registry (CEDAR)

Honours & Awards

2002 Partners in Care Award – BC Children’s Hospital

2005 First Recipient of the Annual Dr. Parminder Singh Award of Distinction for most valuable subspecialty consultant – BC Pediatric Society

2015 Clinical Practice and Advocacy Award from the Canadian League Against Epilepsy

2021 Clinician Practitioner Excellence in Leadership Award from the Pediatrics Chairs of Canada

Award of Distinction from Partners in Care - BC Children’s Hospital, 2006

BC Children’s Hospital Education Award - Education Day for Families, 2005

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