Michael Hayden

PhD, FRSC, FRCPC, MBChB, OBC

Investigator, BC Children's Hospital
Canada Research Chair in Human Genetics and Molecular Medicine
University Killam Professor, Department of Medical Genetics, University of British Columbia

Dr. Hayden’s work focuses on understanding the genetic roots of illness and using that understanding to develop better approaches to treatment for children and families. Author of approximately 950 peer-reviewed publications, Dr. Hayden’s research is primarily on translational medicine, including Huntington Disease, predictive, personalized medicine, drug development, and gene therapy. His research group identified the first mutations underlying Lipoprotein Lipase (LPL) Deficiency in childhood and developed gene therapy approaches to treat this condition resulting in the first approved gene therapy product (Glybera) in a major market. Dr. Hayden is the most cited author in the world on ABCA1 and Huntington Disease.

Academic Affiliations

  • Professor, , Department of Medical Genetics, Faculty of Medicine, University of British Columbia
  • Research Theme: Brain, Behaviour & Development
  • Research Group(s): Implementing Knowledge for Equity and System Change; Mental Health and Behaviour; Neurodevelopmental and Neurological Disorders

Contact Information

Location

950 West 28th Avenue, Vancouver, BC, Canada, V5Z 4H4

Grants

Assessing the pathogenic role of large somatic CAG expansions in striatal neurons of early-onset HD brains with the CAG-CCG loss-of-interruption (LOI) (Hereditary Disease Foundation)

Determining the Role of Somatic Instability, RAN Translation and RNA Toxicity as Mechanistic Drivers of CAG- CCG Modifier Variants in the HD Brain (Huntington Society of Canada)

Novel approaches directed to prevention and treatment of Huntington Disease (CIHR)

Honours & Awards

Doctor of Science in Medicine (honoris causa), University of Cape Town, 2024

Lifetime Achievement Award, Huntington Study Group, USA, 2023

Humanitarian Award, American Friends of Soroka Medical Center, 2020

Inductee, Canadian Medical Hall of Fame, 2017

Order of Canada, 2010

Order of British Columbia, 2009

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