A new study by researchers at the University of British Columbia, BC Children’s Hospital and the University of Manitoba has found that bacteria are shared and possibly transferred from a mother’s milk to her infant’s gut, and that breastfeeding directly at the breast best supports this process.
The research, published today in Cell Host & Microbe, found that certain bacteria, including Streptococcus and Veillonella, co-occur in mothers’ milk and their infants’ stool, and this co-occurrence is higher when infants nurse directly at the breast.
“Our study confirms that breast milk is a major driver of infant gut microbiota development,” said study author Dr. Stuart Turvey, a pediatric immunologist and investigator at BC Children’s, Aubrey J. Tingle professor of pediatric immunology, Canada Research Chair in Pediatric Precision Health and professor in the University of British Columbia (UBC) department of pediatrics. “We found that breastfeeding exclusivity and duration was strongly associated with a baby’s overall gut microbiota composition and that breast milk bacteria shape a baby’s gut microbiome to a similar degree as other known modifiers of the gut microbiota such as birth mode meaning a cesarean-section or vaginal delivery.”
According to the researchers, this is the first study to evaluate the association of multiple breast milk feeding practices (mode, exclusivity, and duration), milk bacteria, and milk components with infant gut microbiota composition at multiple time points in a baby’s first year.
The researchers analyzed the microbiome of infants’ stool and their mothers’ breastmilk using 16S rRNA sequencing, a technique used to identify, classify and determine the abundance of microbes.
The 1,249 mother-baby pairs involved in the research are participating in the CHILD Cohort Study (CHILD), a world-leading birth cohort study in maternal, newborn and child health research. CHILD was launched in 2008 by the Canadian Institutes of Health Research and the Allergy, Genes and Environment Network. Since 2008, CHILD investigators have tracked the health, growth and environments of nearly 3,500 children across Canada from birth and made important discoveries about how asthma and allergies develop.
The findings build upon previous CHILD research that showed pumping breast milk is associated with differences in both milk microbiota composition and infant health.
“Uniquely, our study showed that while breast milk and the infant gut have distinct microbiota compositions, there are a few commonly shared bacteria that were more prevalent and abundant in breast milk of mothers who only nursed directly at the breast, while other bacteria showed dose-dependent associations with exclusive breastfeeding,” said the study co-author Dr. Brett Finlay, professor in the departments of biochemistry and molecular biology, and microbiology and immunology at UBC.
“These results advance the hypothesis that breast milk may act as an incubator that enriches, protects and transports certain bacteria to a baby’s intestinal tract and this may give us clues about which bacteria could make good probiotics since they appear to withstand the trip to the baby’s gut.”
The collaborative study was co-led by Dr. Turvey, Dr. Finlay and Dr. Meghan Azad, Canada Research Chair in Developmental Origins of Chronic Disease at the University of Manitoba, and co-director of the Manitoba Interdisciplinary Lactation Centre at the Children’s Hospital Research Institute of Manitoba.
Trainees Rozlyn Boutin and Dr. Hind Sbihi at UBC, and Kelsey Fehr and Dr. Shirin Moossavi at the University of Manitoba were the study’s co-first authors.
Credit: UBC News Story, July 10, 2020
