Overview

Endometriosis affects one in ten women, and is a common cause of pelvic pain and infertility. It is a condition where tissue from inside the womb, grows outside the womb, typically elsewhere inside the abdomen. In particular, endometriosis causes pelvic pain with intercourse (deep dyspareunia), which can have a devastating impact on women’s quality-of-life and relationships.

The focus of my research is on how endometriosis causes deep dyspareunia. I am investigating the genetic, cellular, nervous system, and psychological factors that lead to pain with intercourse in endometriosis. The goal is to identify the ideal treatments to reduce pain and improve sexual function in endometriosis.

Publications

Endometriosis and endometriosis-associated cancers: new insights into the molecular mechanisms of ovarian cancer development
ecancermedicalscience
Amy Dawson and Marta Llauradó Fernandez and Michael Anglesio and Paul J Yong and Mark S Carey
DOI: 10.3332/ecancer.2018.803
01/2018

Chronic pelvic pain in an interdisciplinary setting: 1-year prospective cohort
American Journal of Obstetrics and Gynecology
Catherine Allaire and Christina Williams and Sonja Bodmer-Roy and Sean Zhu and Kristina Arion and Kristin Ambacher and Jessica Wu and Ali Yosef and Fontayne Wong and Heather Noga and Susannah Britnell and Holly Yager and Mohamed A. Bedaiwy and Arianne Y. Albert and Sarka Lisonkova and Paul J. Yong
DOI: 10.1016/j.ajog.2017.10.002
01/2018

Reproductive Outcomes after Fertility-Sparing Surgery for Focal and Diffuse Adenomyosis: a Systematic Review
Journal of Minimally Invasive Gynecology
Justin Tan and Sophie Moriarty and Omur Taskin and Catherine Allaire and Christina Williams and Paul Yong and Mohamed A. Bedaiwy
DOI: 10.1016/j.jmig.2017.12.020
01/2018

Deep Dyspareunia in Endometriosis: A Proposed Framework Based on Pain Mechanisms and Genito-Pelvic Pain Penetration Disorder
Sexual Medicine Reviews
Paul J. Yong
DOI: 10.1016/j.sxmr.2017.06.005
10/2017

HOXB4 Immunoreactivity in Endometrial Tissues From Women With or Without Endometriosis
Reproductive Sciences
Ghadeer M. AlKusayer and Julia R. Pon and Bo Peng and Christian Klausen and Sarka Lisonkova and Mary Kinloch and Paul Yong and Eman M. S. Muhammad and Peter C. K. Leung and Mohamed A. Bedaiwy
DOI: 10.1177/1933719117732164
10/2017

Factors Associated with Severity of Irritable Bowel Syndrome Symptoms in Patients with Endometriosis
Journal of Obstetrics and Gynaecology Canada
Caroline E. Lee and Paul J. Yong and Christina Williams and Catherine Allaire
DOI: 10.1016/j.jogc.2017.06.025
09/2017

Differential expression of Kisspeptin and its receptor in eutopic and ectopic endometrium of women with and without endometriosis
Fertility and Sterility
A.O. Abdelkareem and A. Ait-Allah and S.M. Rasheed and Y.A. Helmy and C. Allaire and B. Peng and P. Yong and M.A. Bedaiwy
DOI: 10.1016/j.fertnstert.2017.07.146
09/2017

Temporal trends in severe morbidity associated with ectopic pregnancy requiring hospitalization
Fertility and Sterility
S. Lisonkova and Q. Wen and L. Abdellatif and S. Alfaraj and P. Yong and M.A. Bedaiwy
DOI: 10.1016/j.fertnstert.2017.07.321
09/2017

Anatomic Sites and Associated Clinical Factors for Deep Dyspareunia
Sexual Medicine
Paul J. Yong and Christina Williams and Ali Yosef and Fontayne Wong and Mohamed A. Bedaiwy and Sarka Lisonkova and Catherine Allaire
DOI: 10.1016/j.esxm.2017.07.001
09/2017

Pain Catastrophizing and Pain Health-related Quality-of-life in Endometriosis
The Clinical Journal of Pain
Allison E. McPeak and Catherine Allaire and Christina Williams and Arianne Albert and Sarka Lisonkova and Paul J. Yong
DOI: 10.1097/ajp.0000000000000539
07/2017

Nerve Growth Factor Is Associated With Sexual Pain in Women With Endometriosis
Reproductive Sciences
Bo Peng and Hong Zhan and Fahad Alotaibi and Ghadeer M. Alkusayer and Mohamed A. Bedaiwy and Paul J. Yong
DOI: 10.1177/1933719117716778
07/2017

New developments in the medical treatment of endometriosis
Fertility and Sterility
Mohamed A. Bedaiwy and Sukinah Alfaraj and Paul Yong and Robert Casper
DOI: 10.1016/j.fertnstert.2016.12.025
03/2017

Hospital-associated Costs of Chronic Pelvic Pain in Canada: A Population-based Descriptive Study
Journal of Obstetrics and Gynaecology Canada
Innie Chen and Kednapa Thavorn and Minxue Shen and Yvette Goddard and Paul Yong and George S. MacRae and Corrine Nishi and Ayah Matar and Catherine Allaire
DOI: 10.1016/j.jogc.2016.12.008
03/2017

Endometriosis-associated Ovarian Cancers
Clinical Obstetrics and Gynecology
MICHAEL S. ANGLESIO and PAUL J. YONG
DOI: 10.1097/grf.0000000000000320
2017

An interdisciplinary approach to endometriosis-associated persistent pelvic pain
Journal of Endometriosis and Pelvic Pain Disorders
Catherine Allaire and Tuba Aksoy and Mohamed Bedaiwy and Susannah Britnell and Heather L. Noga and Holly Yager and Paul J. Yong
DOI: 10.5301/jeppd.5000284
2017

Up-regulated hyaluronan synthase 2 mediates epidermal growth factor-induced cell migration and invasion in human endometriotic stromal cells
Fertility and Sterility
B. Peng and H. Zhan and P. Yong and P.C. Leung and J. Lin and M.A. Bedaiwy
DOI: 10.1016/j.fertnstert.2016.07.797
09/2016

Abdominal Wall Pain in Women With Chronic Pelvic Pain
Journal of Obstetrics and Gynaecology Canada
Justin Mui and Catherine Allaire and Christina Williams and Paul J. Yong
DOI: 10.1016/j.jogc.2015.11.003
02/2016

Teaching Vaginal Surgery to Junior Residents: Initial Validation of 3 Novel Procedure-Specific Low-Fidelity Models
Journal of Surgical Education
Roxana Geoffrion and Michael W. Suen and Nicole A. Koenig and Paul Yong and Erin Brennand and Neeraj Mehra and Maryse Larouche and Terry Lee and Nicole J. Todd
DOI: 10.1016/j.jsurg.2015.09.004
01/2016

Medical Management of Endometriosis in Patients with Chronic Pelvic Pain
Seminars in Reproductive Medicine
Catherine Allaire and Paul Yong and Sukinah Alfaraj and Mohamed Bedaiwy
DOI: 10.1055/s-0036-1597308
2016

Multifactorial contributors to the severity of chronic pelvic pain in women
American Journal of Obstetrics and Gynecology
Ali Yosef and Catherine Allaire and Christina Williams and Abdel Ghaffar Ahmed and Tarek Al-Hussaini and Mohamad S. Abdellah and Fontayne Wong and Sarka Lisonkova and Paul J. Yong
DOI: 10.1016/j.ajog.2016.07.023
2016

An Evaluation Model for a Multidisciplinary Chronic Pelvic Pain Clinic: Application of the RE-AIM Framework
Journal of Obstetrics and Gynaecology Canada
Innie Chen and Deborah Money and Paul Yong and Christina Williams and Catherine Allaire
DOI: 10.1016/s1701-2163(15)30151-1
09/2015

Expression of HOXB4 in endometrial tissues from women with or without endometriosis
Fertility and Sterility
G.M. Alkusayer and B. Peng and C. Klausen and S. Lisonkova and M. Kinloch and P. Yong and M.A. Bedaiwy
DOI: 10.1016/j.fertnstert.2015.07.489
09/2015

Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden
The Journal of Pathology
Michael S Anglesio and Ali Bashashati and Yi Kan Wang and Janine Senz and Gavin Ha and Winnie Yang and Mohamed R Aniba and Leah M Prentice and Hossein Farahani and Hector Li Chang and Anthony N Karnezis and Marco A Marra and Paul J Yong and Martin Hirst and Blake Gilks and Sohrab P Shah and David G Huntsman
DOI: 10.1002/path.4516
03/2015

Concurrent Deep–Superficial Dyspareunia: Prevalence, Associations, and Outcomes in a Multidisciplinary Vulvodynia Program
The Journal of Sexual Medicine
Paul J. Yong and Leslie Sadownik and Lori A. Brotto
DOI: 10.1111/jsm.12729
01/2015

Impact of a Multidisciplinary Vulvodynia Program on Sexual Functioning and Dyspareunia
The Journal of Sexual Medicine
Lori A. Brotto and Paul Yong and Kelly B. Smith and Leslie A. Sadownik
DOI: 10.1111/jsm.12718
01/2015

Nerve Bundles and Deep Dyspareunia in Endometriosis
Reproductive Sciences
Christina Williams and Lien Hoang and Ali Yosef and Fahad Alotaibi and Catherine Allaire and Lori Brotto and Ian S. Fraser and Mohamed A. Bedaiwy and Tony L. Ng and Anna F. Lee and Paul J. Yong
DOI: 10.1177/1933719115623644
2015

Pelvic Floor Tenderness in the Etiology of Superficial Dyspareunia
Journal of Obstetrics and Gynaecology Canada
Paul J. Yong and Justin Mui and Catherine Allaire and Christina Williams
DOI: 10.1016/s1701-2163(15)30414-x
11/2014

Routes of hysterectomy in women with benign uterine disease in the Vancouver Coastal Health and Providence Health Care regions: a retrospective cohort analysis
Canadian Medical Association Journal
Chen, Innie and Lisonkova, Sarka and Allaire, Catherine and Williams, Christina and Yong, Paul and Joseph, K.S.
DOI: 10.9778/cmajo.20130080
PubMed: 25485254
11/2014

Laparoscopic Versus Abdominal Myomectomy: Practice Patterns and Health Care Use in British Columbia
Journal of Obstetrics and Gynaecology Canada
Innie Chen and Sarka Lisonkova and K.S. Joseph and Christina Williams and Paul Yong and Catherine Allaire
DOI: 10.1016/s1701-2163(15)30484-9
09/2014

Is Endometriosis a Surgical Disease?
Surgery: Current Research
Paul J Yong and Christina William
DOI: 10.4172/2161-1076.1000164
2014

Surgery for pelvic pain in endometriosis
Pain Management Yearbook 2013
2014

Bladder Base Tenderness in the Etiology of Deep Dyspareunia
The Journal of Sexual Medicine
Melica Nourmoussavi and Sonja Bodmer-Roy and Justin Mui and Narissa Mawji and Christina Williams and Catherine Allaire and Paul J. Yong
DOI: 10.1111/jsm.12708
2014

Needs Assessment of Obstetrician-Gynaecologists in British Columbia for the Care of Women with Endometriosis and Chronic Pelvic Pain
Reproductive System & Sexual Disorders
Paul Yong
DOI: 10.4172/2161-038x.1000128
2014

Pilot Study of Pelvic Girdle Pain in Women With and Without Laparoscopically Diagnosed Endometriosis
International Journal of Surgery Research & Practice
Paul J Yong
DOI: 10.23937/2378-3397/1410011
2014

Endovaginal ultrasound-assisted pain mapping in endometriosis and chronic pelvic pain
Journal of Obstetrics and Gynaecology
P. J. Yong and C. Sutton and M. Suen and C. Williams
DOI: 10.3109/01443615.2013.821971
10/2013

Laparoscopic Inguinal Exploration and Mesh Placement for Chronic Pelvic Pain
JSLS : Journal of the Society of Laparoendoscopic Surgeons
Paul J. Yong and Christina Williams and Catherine Allaire
DOI: 10.4293/108680812x13517013317310
2013

Choosing the right surgery for endometriosis and pelvic pain
Endometriosis: Risk Factors, Symptoms, and Management
2013

Development of an interdisciplinary pelvic pain and endometriosis clinic
BC Medical Journal
2013

Fertility awareness in gynecology and women’s health: application to family planning and endometriosis
Linacre Quarterly
2013

Infertility management in a Canadian family practice
Linacre Quarterly
2013

Surgery for pelvic pain in endometriosis
Journal of Pain Management
2013

Clinical Predictors of Endometriosis in the Infertility Population: Is There a Better Way to Determine Who Needs a Laparoscopy?
Journal of Obstetrics and Gynaecology Canada
Kellie Whitehill and Paul J. Yong and Christina Williams
DOI: 10.1016/s1701-2163(16)35271-9
06/2012

Protein Kinase Profiling in Miscarriage: Implications for the Pathogenesis of Trisomic Pregnancy
Journal of Obstetrics and Gynaecology Canada
Paul J. Yong and Deborah E. McFadden and Wendy P. Robinson
DOI: 10.1016/s1701-2163(16)35461-5
2012

Prediction of Pediatric Outcome after Prenatal Diagnosis and Expectant Antenatal Management of Congenital Cystic Adenomatoid Malformation
Fetal Diagnosis and Therapy
Paul J. Yong and Peter Von Dadelszen and Daniela Carpara and Ken Lim and Nancy Kent and Francine Tessier and Marie-France Delisle and Titus Wong and Geoffrey Blair and Erik D. Skarsgard
DOI: 10.1159/000331936
2012

Transvaginal Repair and Graft Interposition for Rectovaginal Fistula Due to a Neglected Pessary
Female Pelvic Medicine & Reconstructive Surgery
Paul J. Yong and Matthew M. Garrey and Roxana Geoffrion
DOI: 10.1097/spv.0b013e3182282c4e
07/2011

Developmental Origin of Chorionic Villus Cultures From Spontaneous Abortion and Chorionic Villus Sampling
Journal of Obstetrics and Gynaecology Canada
Paul J. Yong and Deborah E. McFadden and Wendy P. Robinson
DOI: 10.1016/s1701-2163(16)34877-0
05/2011

Monochorionic Diamniotic Triplet Pregnancy With Prenatal Diagnosis of Cord Entanglement
Journal of Obstetrics and Gynaecology Canada
Paul J. Yong and Duncan F. Farquharson and Jagdeep Ubhi
DOI: 10.1016/s1701-2163(16)34455-3
03/2010

Placental Weight in Pregnancies With Trisomy Confined to the Placenta
Journal of Obstetrics and Gynaecology Canada
Paul J. Yong and Peter von Dadelszen and Deborah E. McFadden and Irene J. Barrett and Dagmar K. Kalousek and Wendy P. Robinson
DOI: 10.1016/s1701-2163(16)34239-6
07/2009

Expectant management of pre-eclampsia remote from term: A structured review of maternal and perinatal outcomes
Hypertension in Pregnancy
2009

The association between preeclampsia and placental trisomy 16 mosaicism
Prenatal Diagnosis
Paul J. Yong and Sylvie Langlois and Peter von Dadelszen and Wendy Robinson
DOI: 10.1002/pd.1534
2006

Postnatal follow-up of prenatally diagnosed trisomy 16 mosaicism
Prenatal Diagnosis
Sylvie Langlois and Paul J. Yong and Siu Li Yong and Irene Barrett and Dagmar K. Kalousek and Peter Miny and Rita Exeler and Kathy Morris and Wendy P. Robinson
DOI: 10.1002/pd.1457
2006

Decidual NK Cells Alter In Vitro First Trimester Extravillous Cytotrophoblast Migration: A Role for IFN- 
The Journal of Immunology
Y. Hu and J. P. Dutz and C. D. MacCalman and P. Yong and R. Tan and P. von Dadelszen
DOI: 10.4049/jimmunol.177.12.8522
2006

Clinical aspects, prenatal diagnosis, and pathogenesis of trisomy 16 mosaicism
Journal of Medical Genetics
P J Yong
DOI: 10.1136/jmg.40.3.175
03/2003

Evidence for imprinting on chromosome 16: The effect of uniparental disomy on the outcome of mosaic trisomy 16 pregnancies
American Journal of Medical Genetics
P.J. Yong and S.A. Marion and I.J. Barrett and D.K. Kalousek and W.P. Robinson
DOI: 10.1002/ajmg.10702
09/2002

16 The evolution of gene duplicates
Homology Effects
S OTTO and P YONG
DOI: 10.1016/s0065-2660(02)46017-8
2002

Research

Current Projects
Pathophysiology of deep endometriosis: Deep invasive endometriosis is an invasive type of endometriosis that leads to deep dyspareunia and painful bowel movements (dyschezia). I am exploring the cellular and genetic mechanisms behind this invasive form of endometriosis.

Current Projects
Local neurogenesis and deep dyspareunia in endometriosis: I am studying the role of local nerve growth in the pelvis (the pouch of Douglas and uterosacral ligaments) as a cause of deep dyspareunia in endometriosis.

Current Projects
Clinical predictors of deep dyspareunia in endometriosis: Using a prospective database that I developed, I am investigating the variables from history, validated questionnaires, physical examination, and surgical findings, that are associated with deep dyspareunia (and other pain) in endometriosis.

Grants

CIHR Operating Grant (2015-2018) ($282,000)

CFI John Evans Leaders Fund (2015-2016) ($312,500 with matching funds)

CIHR Operating Grant Priority Announcement (2014-2015) ($100,000)

Honours & Awards

Best abstract in pelvic pain. AAGL Global Congress, Vancouver, BC, October 2014.(Presented by trainee)

Best oral presentation (Gynaecology), Society of Obstetricians and Gynaecologists of Canada (SOGC) Annual Meeting, Niagrara Falls, ON, June 2014.

Research Group Members

Fahad Alotaibi, Trainee
Caroline Lee, Clinical Fellow
Olena Maydan, Research Assistant, Research Assistant
Heather Noga, Research Manager
Hessey Ohm, Medical Student
Natasha Orr, Trainee
Kate Wahl, Research Trainee