Overview

Infections in children are still a major cause of early morbidity and mortality throughout the world, despite the advances made in preventive care. Infections are often a reason for children to become critically ill, and often occur in the critically ill child. My research focuses upon stemming this burden through optimizing their management in a variety of settings. Additionally, the ability of various settings and healthcare systems to cost-effectively manage critically ill children, especially those with infection, is an area of focus.

Publications

The Potential Harm of Cytomegalovirus Infection in Immunocompetent Critically Ill Children
Frontiers in Pediatrics
Raidan Alyazidi, Srinivas Murthy, Jennifer A. Slyker, Soren Gantt
DOI: 10.3389/fped.2018.00096
04/2018

Dopamine and the Risk for Hospital-Acquired Infections*
Pediatric Critical Care Medicine
Srinivas Murthy
DOI: 10.1097/pcc.0000000000001446
03/2018

Evidence-based guidelines for supportive care of patients with Ebola virus disease
The Lancet
François Lamontagne, Robert A Fowler, Neill K Adhikari, Srinivas Murthy, David M Brett-Major, Michael Jacobs, Timothy M Uyeki, Constanza Vallenas, Susan L Norris, William A Fischer, Thomas E Fletcher, Adam C Levine, Paul Reed, Daniel G Bausch, Sandy Gove, Andrew Hall, Susan Shepherd, Reed A Siemieniuk, Marie-Claude Lamah, Rashida Kamara, Phiona Nakyeyune, Moses J Soka, Ama Edwin, Afeez A Hazzan, Shevin T Jacob, Mubarak Mustafa Elkarsany, Takuya Adachi, Lynda Benhadj, Christophe Clément, Ian Crozier, Armando Garcia, Steven J Hoffman, Gordon H Guyatt
DOI: 10.1016/s0140-6736(17)31795-6
02/2018

Non-invasive ventilation in children and adults in low- and low-middle income countries: A systematic review and meta-analysis
Journal of Critical Care
Keren Mandelzweig, Aleksandra Leligdowicz, Srinivas Murthy, Rejani Lalitha, Robert A. Fowler, Neill K.J. Adhikari
DOI: 10.1016/j.jcrc.2018.01.007
01/2018

Recommendations on infrastructure and organization of adult ICUs in resource-limited settings
Intensive Care Medicine
Alfred Papali, for the European Society of Intensive Care Medicine (ESICM) Global Intensive Care working group and The Mahidol–Oxford Research Unit (MORU) in Bangkok, Thailand, Marcus J. Schultz, Martin W. Dünser
DOI: 10.1007/s00134-017-4972-0
11/2017

The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Ian M. Ball, for the Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group, Lisa Burry, Peter Dodek, Jamie S. Hutchison, Jeanna Parsons Leigh, Victoria McCredie, Srinivas Murthy, Bram Rochwerg, Deborah Cook
DOI: 10.1007/s12630-017-1016-8
11/2017

Outcome Measures in Sepsis, Revisited*
Pediatric Critical Care Medicine
Srinivas Murthy
DOI: 10.1097/pcc.0000000000001209
08/2017

Burden of diarrhea in the Eastern Mediterranean Region, 1990–2015: Findings from the Global Burden of Disease 2015 study
International Journal of Public Health
Ali H. Mokdad, GBD 2015 Eastern Mediterranean Region Diarrhea Collaborators
DOI: 10.1007/s00038-017-1008-z
08/2017

Selective digestive decontamination in critically ill children: A survey of Canadian providers
Journal of Critical Care
Srinivas Murthy, Nazima Pathan, Brian H. Cuthbertson
DOI: 10.1016/j.jcrc.2017.02.024
06/2017

Perioperative antibiotics in pediatric cardiac surgery: protocol for a systematic review
Systematic Reviews
Vijay Anand, Angela Bates, Robin Featherstone, Srinivas Murthy
DOI: 10.1186/s13643-017-0502-y
05/2017

Vasopressor use following traumatic injury: protocol for a systematic review
BMJ Open
Mathieu Hylands, Augustin Toma, Nicolas Beaudoin, Anne-Julie Frenette, Frederick D'Aragon, Emilie Belley-Côté, Morten Hylander, François Lauzier, Reed Alexander Siemieniuk, Emmanuel Charbonney, Joey Kwong, Jon Henrik Laake, Gordon Guyatt, Per Olav Vandvik, Bram Rochwerg, Robert Green, Ian Ball, Damon Scales, Srinivas Murthy, Sandro Rizoli, Pierre Asfar, François Lamontagne
DOI: 10.1136/bmjopen-2016-014166
02/2017

Design and a-testing of an electronic rounding tool (CERTAINp) to improve process of care in pediatric intensive care unit
Journal of Clinical Monitoring and Computing
Manasi Hulyalkar, Stephen J. Gleich, Rahul Kashyap, Amelia Barwise, Harsheen Kaur, Yue Dong, Lei Fan, Srinivas Murthy, Grace M. Arteaga, Sandeep Tripathi
DOI: 10.1007/s10877-016-9946-1
10/2016

Who Says There Is No “I” in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care
American Journal of Respiratory and Critical Care Medicine
Raquel R. Bartz, Dashiell Gantner, Anthony C. Gordon, Aleksandra Leligdowicz, James J. McNamee, Srinivas Murthy, Alistair Nichol, Steve Webb
DOI: 10.1164/rccm.201602-0405le
10/2016

Pediatric sepsis and septic shock management in resource-limited settings
Intensive Care Medicine
Ndidiamaka Musa, Srinivas Murthy, Niranjan Kissoon
DOI: 10.1007/s00134-016-4382-8
05/2016

A survey on the resources and practices in pediatric critical care of resource-rich and resource-limited countries
Journal of Intensive Care
Sandeep Tripathi, Harsheen Kaur, Rahul Kashyap, Yue Dong, Ognjen Gajic, Srinivas Murthy
DOI: 10.1186/s40560-015-0106-3
10/2015

Management of severe viral infections in the pediatric intensive care unit
Journal of Pediatric Intensive Care
Srinivas Murthy, Niranjan Kissoon
DOI: 10.3233/pic-14103
07/2015

Industry-sponsored clinical research outside high-income countries: an empirical analysis of registered clinical trials from 2006 to 2013
Health Research Policy and Systems
Srinivas Murthy, Kenneth D. Mandl, Florence T. Bourgeois
DOI: 10.1186/s12961-015-0019-6
06/2015

Ebola and provision of critical care
The Lancet
Srinivas Murthy
DOI: 10.1016/s0140-6736(15)60712-7
04/2015

Ebola Virus Disease among Children in West Africa
New England Journal of Medicine
WHO Ebola Response Team
DOI: 10.1056/nejmc1415318
03/2015

Being Ready to Treat Ebola Virus Disease Patients
The American Journal of Tropical Medicine and Hygiene
David M. Brett-Major, Shevin T. Jacob, Barbara J. Shea, Frederique A. Jacquerioz, Henry Kyobe Bosa, John S. Schieffelin, Tim O'Dempsey, Gary G. Kuniyoshi, Sara K. Hurley, John C. Carlson, David T. Porembka, Takuya Adachi, William A. Fischer, Catherine F. Houlihan, Daniel G. Bausch, Robert A. Fowler, Susan L. McLellan, Thomas E. Fletcher, Lewis Rubinson, Francois Lamontagne, James V. Lawler, George F. Risi, Srinivas G. Murthy, Suzanne M. Donovan, Nicola Petrosillo, Mauricio Ferri, Louise E. Berry, Thomas. C. Button, Yasuyuki Kato, Ian Crozier
DOI: 10.4269/ajtmh.14-0746
02/2015

Intensive Care Unit Capacity in Low-Income Countries: A Systematic Review
PLOS ONE
Srinivas Murthy, Aleksandra Leligdowicz, Neill K. J. Adhikari
DOI: 10.1371/journal.pone.0116949
01/2015

Critical Care in Low-Resource Settings
The Organization of Critical Care
Srinivas Murthy, Sadath A. Sayeed, Neill K. J. Adhikari
DOI: 10.1007/978-1-4939-0811-0_16
2014

Global Health Care of the Critically Ill in Low-Resource Settings
Annals of the American Thoracic Society
Srinivas Murthy, Neill K. Adhikari
DOI: 10.1513/annalsats.201307-246ot
10/2013

Innominate artery aneurysm after cannulation for extracorporeal membrane oxygenation via the right carotid artery
Intensive Care Medicine
Srinivas Murthy, Cathy MacDonald, Osami Honjo, Alejandro A. Floh, Tilman Humpl
DOI: 10.1007/s00134-013-3070-1
08/2013

Infections of the Developing World
Critical Care Clinics
Srinivas Murthy, Jay Keystone, Niranjan Kissoon
DOI: 10.1016/j.ccc.2013.03.005
07/2013

Analysis of Pediatric Clinical Drug Trials for Neuropsychiatric Conditions
PEDIATRICS
S. Murthy, K. D. Mandl, F. Bourgeois
DOI: 10.1542/peds.2012-2694
05/2013

Access to urban acute care services in high- vs. middle-income countries: an analysis of seven cities
Intensive Care Medicine
Shamly Austin, On behalf of the International Forum of Acute Care Trialists, Srinivas Murthy, Hannah Wunsch, Neill K. J. Adhikari, Veena Karir, Kathryn Rowan, Shevin T. Jacob, Jorge Salluh, Fernando A. Bozza, Bin Du, Youzhong An, Bruce Lee, Felicia Wu, Yen-Lan Nguyen, Chris Oppong, Ramesh Venkataraman, Vimalraj Velayutham, Carmelo Dueñas, Derek C. Angus
DOI: 10.1007/s00134-013-3174-7
2013

Network Analysis of Transcriptional Responses Induced by Mesenchymal Stem Cell Treatment of Experimental Sepsis
The American Journal of Pathology
Claudia C. dos Santos, Srinivas Murthy, Pingzhao Hu, Yuexin Shan, Jack J. Haitsma, Shirley H.J. Mei, Duncan J. Stewart, W. Conrad Liles
DOI: 10.1016/j.ajpath.2012.08.009
11/2012

Pediatric Versus Adult Drug Trials for Conditions With High Pediatric Disease Burden
PEDIATRICS
F. T. Bourgeois, S. Murthy, C. Pinto, K. L. Olson, J. P. A. Ioannidis, K. D. Mandl
DOI: 10.1542/peds.2012-0139
07/2012

After the FEAST—Fluid Resuscitation in Pediatric Sepsis
The Indian Journal of Pediatrics
Srinivas Murthy, Niranjan Kissoon
DOI: 10.1007/s12098-012-0845-2
07/2012

The Role and Impact of Research Agendas on the Comparative-Effectiveness Research Among Antihyperlipidemics
Clinical Pharmacology & Therapeutics
A G Dunn, F T Bourgeois, S Murthy, K D Mandl, R O Day, E Coiera
DOI: 10.1038/clpt.2011.279
02/2012

Comparative Effectiveness Research: An Empirical Study of Trials Registered in ClinicalTrials.gov
PLoS ONE
Florence T. Bourgeois, Srinivas Murthy, Kenneth D. Mandl
DOI: 10.1371/journal.pone.0028820
01/2012

Clinical review: International comparisons in critical care - lessons learned
Critical Care
Srinivas Murthy, Hannah Wunsch
DOI: 10.1186/cc11140
2012

Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review
Critical Care
Katharine Xing, Srinivas Murthy, W Conrad Liles, Jeffrey M Singh
DOI: 10.1186/cc11145
2012

Infectious Diseases Following Disasters
Disaster Medicine and Public Health Preparedness
Srinivas Murthy, Michael D. Christian
DOI: 10.1001/dmp.2010.hcn10005
10/2010

Outcome Reporting Among Drug Trials Registered in ClinicalTrials.gov
Annals of Internal Medicine
Florence T. Bourgeois
DOI: 10.7326/0003-4819-153-3-201008030-00006
08/2010

Research

Biomarkers in pediatric sepsis
Being able to stratify children with severe sepsis, so as to better triage their care and predict their outcome, is a long-standing challenge. I am investigating the role of a panel of novel biomarkers, detected in blood, in predicting the outcome of children. This will be of tremendous help for research purposes, for front-line providers assessing the severity of illness, and for improving the understanding of the mechanism of the complex septic reaction.

Grants

2011 University of Toronto Elizabeth Arbuthnot Dyson Fellowship

2011 University of Toronto Joseph M. West Family Memorial Fund Fellowship

Research Group Members

Kira Genise, Student
Sean Wong, Medical Student