Overview

As you read this paragraph, two infants in the world will have died from an infection for which there is an effective vaccine. Worldwide we could save millions of infants every year - if only we could immunize them on time. The work in our lab focuses on part of the science to help solve this problem.

Publications

Mortality Risk Among Frail Neonates and Maternal BCG Vaccine Scar Status: Observational Study From Guinea-Bissau
The Journal of Infectious Diseases
Frederik Schaltz-Buchholzer and Peter Aaby and Isaquel Silva and Ivan Monteiro and Tobias R Kollmann and Nelly Amenyogbe and Morten Bjerregaard-Andersen and Christine Stabell Benn
DOI: 10.1093/infdis/jiac140
05/2023

A systems biology approach to better understand human tick-borne diseases
Trends in Parasitology
Wenna Lee and Amanda D. Barbosa and Peter J. Irwin and Andrew Currie and Tobias R. Kollmann and Miles Beaman and Amy H. Lee and Charlotte L. Oskam
DOI: 10.1016/j.pt.2022.10.006
01/2023

The safety of co-administration of Bacille Calmette-Guérin (BCG) and influenza vaccines
PLOS ONE
Paola Villanueva and Ushma Wadia and Nigel W. Crawford and Nicole L. Messina and Tobias R. Kollmann and Michaela Lucas and Laurens Manning and Peter Richmond and Laure F. Pittet and Nigel Curtis
DOI: 10.1371/journal.pone.0268042
06/2022

Cutaneous CpG adjuvant conditioning to enhance vaccine responses
Vaccine
Douglas A. Carlow and Jacqueline C.Y. Lai and Tobias R. Kollmann and Manish Sadarangani and Jan P. Dutz
DOI: 10.1016/j.vaccine.2021.12.060
03/2022

Revaccination with Bacille Calmette-Guérin (BCG) is associated with an increased risk of abscess and lymphadenopathy
npj Vaccines
Villanueva, P. and Wadia, U. and Crawford, N. and Messina, N.L. and Kollmann, T.R. and Lucas, M. and Manning, L. and Richmond, P. and Pittet, L.F. and Curtis, N.
DOI: 10.1038/s41541-021-00421-5
2022

Microbial antigen in human milk: a natural vaccine?
Mucosal Immunology
van den Elsen, L.W.J. and Kollmann, T.R. and Verhasselt, V.
DOI: 10.1038/s41385-022-00561-4
2022

Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells
PLoS Biology
Zhu, Y. and Chew, K.Y. and Wu, M. and Karawita, A.C. and McCallum, G. and Steele, L.E. and Yamamoto, A. and Labzin, L.I. and Yarlagadda, T. and Khromykh, A.A. and Wang, X. and Sng, J.D.J. and Stocks, C.J. and Xia, Y. and Kollmann, T.R. and Martino, D. and Joensuu, M. and Meunier, F.A. and Balistreri, G. and Bielefeldt-Ohmann, H. and Bowen, A.C. and Kicic, A. and Sly, P.D. and Spann, K.M. and Short, K.R.
DOI: 10.1371/journal.pbio.3001728
2022

A single birth dose of Hepatitis B vaccine induces polyfunctional CD4+ T helper cells
Frontiers in Immunology
Strandmark, J. and Darboe, A. and Diray-Arce, J. and Ben-Othman, R. and Vignolo, S.M. and Rao, S. and Smolen, K.K. and Leroux-Roels, G. and Idoko, O.T. and Sanchez-Schmitz, G. and Ozonoff, A. and Levy, O. and Kollmann, T.R. and Marchant, A. and Kampmann, B.
DOI: 10.3389/fimmu.2022.1043375
2022

Off-target effects of bacillus Calmette–Guérin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19
Clinical and Translational Immunology
Messina, N.L. and Germano, S. and McElroy, R. and Rudraraju, R. and Bonnici, R. and Pittet, L.F. and Neeland, M.R. and Nicholson, S. and Subbarao, K. and Curtis, N. and Baena, A.S. and Teo, J.W. and de Lima, G.T. and Abreu, C. and Abruzzo, V. and Addlem, L. and Agius, S. and Barbosa, A.A.R. and Alamrousi, A. and da Silva dos Santos, A.A. and Al-Hindawi, Y. and Silveira, S.A.D. and da Cruz, L.A. and Anderson, J. and Nelly, A. and Anthony, C. and dos Reis Pereira, A.A.S.D.A. and de las Revillas Almajano, F.A. and Arnold, A. and Arrowsmith, B. and Azzopardi, K. and Marti, C.B. and Bahaduri, T. and Bannister, S. and Barney, S. and Barrera, L. and Barriocanal, A. and Barros, D. and Barry, S. and Bartlett, A. and Batista, L. and Muranaka, S. and Baulman, T. and Bealing, M. and Beardsley, J. and Gutierrez, A.B.M. and Bell, J. and Benson, S. and Rym, B. and Bennett-Wood, V. and Bergant, N. and Barbosa, F.B. and Bijllaardt, W. and Bimboese, P. and de Andrade, C.B. and Blake, S. and Blauwendraat, K. and Boersma, W. and Garcia, P.B. and Bonten, M. and Boon, A. and Bourke, A. and Bowes, K. and Brasil, L. and Brophy, C. and Botten, R. and Buchanan, S. and Bucholc, J. and Burns, A. and Burrell, E. and Bustos, N. and Byrne, B. and Byrne, A. and Calbo, E. and Montes, J.C. and Camesella, B. and Campbell, J. and Cangas, A. and Carlin, J. and Roque, M.C. and Diogo, R.C.P. and Carvalho, E. and Casas, I. and Castro, E. and Castro, R. and Catterick, H. and Escobar, R.C.D. and Chan, J. and Cheah, J. and Chern, T.Y. and Chengodu, T. and Ciaverella, M. and Clark, S. and Espindola, M.-A.C. and Cobbledick, A. and Colaco, C. and Collopy, S. and Comella, P. and Corbett, M. and Castro, G.C.E. and Costa, E. and Coya, R. and Crawford, N. and Croda, J. and Cruz, A. and Maxwell, C. and Cushnahan, J. and Czajko, A. and da Costa Silva, R. and Daitiri, B. and Dalcolmo, M. and Dalton, K. and Dang, T. and Dao, A. and Davidson, A. and Dawe, P. and Dawson, D. and de Jesus Costa, M. and De La Cruz, K. and de la Serna, A. and de Morais Batista, F. and de Oliveira, A. and del Alba Rey Morillo, R. and Desylva, M. and Dijkstra, H. and Dixon, R. and del Toro Lopez, M.D. and Dominguez, J. and Doran, C. and Castellano, A.D. and Santos, G.D. and dos Santos Lencina, J. and dos Santos Silva, D. and Douglas, M. and Dunn, R. and Dunn, A. and Dunnill, J. and Eden, G. and Peta, E. and Edmund, H. and Eiffler, N. and Elborough, H. and Elia, S. and Elkington, O. and England, M. and Ayala, W.E. and Esteve, M. and Evans, N. and Evans, S. and Ewe, K. and ?lvarez, M.C.F. and Fahey, K. and Fairweather, J. and Faustman, D. and Silva, E.F. and Fernandez, M. and Fidler, G. and Filius, P.M.G. and Finn, A. and Finucane, C. and Firth, S. and Fletcher, E. and Flynn, C. and Flynn, L. and Fouracre, L. and Fowler, S. and Freitas, T. and Furtado, A.C. and Oliveira, M.G. and Santos, A.G. and Gon?alves, L.G.C. and Galletta, L. and Gama, L. and Gamage, D. and Ganpat, R. and Garc{\'i}a, C. and Croda, M.G. and Gardiner, K. and Gardiner, E. and Gell, G. and de Oliveira, A.G. and Germano, S. and Gibbons, M. and Gibson, C. and Gifford, A. and Poderos, T.G. and Ginsberg, A. and Gisolf, J. and Gladanac, B. and Glenn, P. and Godinho, V. and dos Santos, M.G. and Goikoetxea, J. and Goldenberg, T. and Gomes, A. and Marcos, S.G. and Rico, C.G. and Goodall, C. and Goodchild, L. and Gordon, V. and Greven, F. and Capella, A.G. and Griffith, L. and Guo, C. and Campos, D.G. and Cuadra, M.G. and Gwee, A. and Hall, R. and Hall, L. and Hamilton, K. and Hannan, M. and Harbech, H. and Harding, A. and Harker, N. and Harrison, R. and Hassing, R.J. and da Rosa, T.H.S. and Haywood, Z. and Heath, C. and Henare, N. and Andrade, P.H. and Herrmann, S. and Hill, E. and Hilton, S. and Huijbens, D. and Hutton, H. and James, J. and Jamieson, T. and Janssen, A. and Jardim, B. and Jardim, T. and Jarvis, L. and Jenkins, N. and Jones, J. and Jones, J. and Jones, K. and Jorge, L. and Vilegas, M.J.R. and Joshi, S. and Joyce, R. and Junior, J. and Kandasamy, R. and Karunanayake, A. and Karuppasamy, H. and Keeble, T. and Kent, J. and Kloeg, P. and Kluytmans, J. and Knight, B. and Kollmann, T. and Korman, T. and Krastev, A. and Krieg, M. and La, N. and Lacerda, M. and Lacoma, A. and Lagunday, R. and Lalich, D. and Latkovic, E. and Latorre, I. and Meireles, P.L.G. and Lee, K. and Legge, D. and Lemmers, T. and Leurink, T. and Lieschke, K. and Lim, K. and Lockhart, G. and Bog{\'e}a, C.L. and dos Santos, K.L. and Marques, R.L. and Lucas, M. and Lynn, D. and Lynn, M. and Freitas, M.L.S.D. and Ma, N. and Macalister, S. and Machado, C. and Ramos, M.M. and Machingaifa, F. and Maia, I. and Maia, B. and Malley, R. and Manning, L. and Manton, S. and Carrerero, J.M. and Barriocanal, A.M. and Alves, C.M.L. and Pereira, R.M.P. and Arruda, B.M.S.M. and Marins, A. and Markow, A. and Marshall, H. and Martin, C. and Almeida, K.M. and Mather, W. and Mathers, M. and Gomes, F.M.N. and Tadokoro, M.M. and Mazarakis, N. and Mazurega, K. and McAlister, S. and McAndrews, A. and McDonald, E. and McDonald, F. and McMillan, M. and McMullan, B. and McPhate, N. and Mead, L. and Meehan, A. and Meek, B. and Melo, R. and Mena, G. and Mesquita, D. and Mezzetti, I. and Vieira, H.M.R. and Miller, S. and Mitchell, K. and Mitchell, M. and Mojeed, J. and Molenaar, K. and Molina, G. and Molina, B. and Montgomery, L. and Moore, C. and Moore, J. and Moorlag, S. and Morawakage, T. and Moss, J. and Moyle, W. and Mulholland, K. and Munns, C. and Nascimento, E. and Navarrette, N. and Netea, M. and Neves, J. and Newman, G. and Ngien, B. and Nguyen, J. and Nguyen, K. and Noonan, F. and Norton, W. and O?Donnell, M. and O?Bryan, J. and O?Connell, A. and Odoi, S. and O?Donnell, L. and Oliveira, R. and Oliveira, M. and Oliveira, T. and Oliveira, I. and Olivier, N. and Olivio, L. and Ong, B. and Ong, J. and Ong, J. and Onysk, J. and Ooi, I. and Oppedisano, F. and Orsini, F. and Ortika, B. and Otsuka, A. and Overton, K. and Owens, R. and Paes, R. and Palasanthiran, P. and Jim{\'e}nez, V.P. and Pandine, G. and Parkin, K. and Hernandez, A.P. and Paternotte, N. and Paterson, D. and de Souza, A.P.C. and Pelayo, L. and Pell, C. and Pelser, S. and Pereira, H. and Pereira, G. and Perez, G. and Perez, C. and Porcuna, T.P. and Perlen, S. and Perrett, K. and Floy, A.P.D. and Pitkin, S. and Pon, R.C. and Calder{\'o}n, I.P. and Post, J. and Power, C. and Prado, C. and Prajitno, E. and Prat-Aymerich, C. and Preijers, L. and Puga, M. and Queiroz, E. and Quinn, L. and Rak, A. and Figueiredo, L.R. and de Arellano, E.R. and Ramos, P. and de Oliveira, K.R.W. and Ren, J. and Reynolds, S. and Rhodes, S. and dos Santos, C.R. and Richards, C. and Richmond, P. and Richmond, H. and Souza, A.R.L. and Rocha, J. and Rodrigues, T. and Rodrigues, L. and Rodrigues, B. and Fernandes, I.R. and Rodr{\'i}guez-Ba{\~n}o, J. and Roescher, N. and Rogers, S. and Rol, A. and Romme, J. and Rosell, A. and Font, M.R. and Sacca, D. and Sallent, S. and Sampaio, V. and Sanchez, N. and Sanchez, B. and Santos, D. and Santos, T. and Sartim, A. and Sastry, A. and Sawka, A. and Schultz, N. and Seamark, C. and Seamark, D. and Septer-Bijleveld, E. and Serrano, R. and Shann, F. and Sharma, K. and Shave, M. and Shen, L. and Sidaway-Lee, K. and Silva, R. and Silva, J. and Silva, E. and Sim{\~a}o, M. and Singh, R. and Siqueira, M. and All{\~a}o Chaves, M.S.D. and Sondag, T. and Sooriyarachchi, E. and Sousa, A. and Judith, S. and Spry, L. and Statton, S. and Steer, A. and dos Santos, D.S.L. and Sterling, K. and Steve, L. and Stevens, L. and Stevens, N. and Stewart, C. and Stiglmayer, L. and Stooper, L. and Studham, J. and Sudbury, E. and Suiker, A. and Symons, L. and Taks, E. and Tan, N. and Meireles, B.T.L. and te Riele, M. and ten Oever, J. and ter Heine, R. and Angelo, J.T.C. and Thomson, H. and Toh, R. and Trindade, A. and Tripp, H. and Trist{\'a}n, E. and Troeman, D. and Truelove, A. and Tsuha, D. and Uffing, M. and Val, F. and Valero, O. and Valls, E. and van de Ven, C. and Van Den Heuvel, L. and van der Veen, S. and van der Waal, M. and van Leusen, J.H. and van Mook, L. and van Onzenoort, H. and van Opdorp, M. and van Rijen, M. and van Sluis, N. and Vasconcelos, A. and Vega, N. and Velagapudi, S. and Vennells, L. and Venton, T. and Verheij, H. and Verhoeven, P.M. and Ramos, C.V. and da Silva, P.V.R. and Vidal, S. and Vidmar, S. and Vieira, P. and de Oliveira, M.V. and Ortega, R.V. and Villanueva, P. and Villar, R. and Vlahos, A. and Wadia, U. and Walker, M. and Wall, K. and Wallace, R. and Wang, X. and Waring, J. and Warren, R. and Warris, A. and Watts, E. and Wearing-Smith, M. and Webber-Rookes, D. and Wedderburn, J. and Wee-Hee, A. and Wesselingh, S. and Whale, B. and Williams, P. and Wolters, B. and Wood, N. and Xie, I. and Younes, A. and Young, A. and Zampieri, F. and Batista, V. and Zhou, C. and Zwart, V.
DOI: 10.1002/cti2.1387
2022

FastMix: a versatile data integration pipeline for cell type-specific biomarker inference
Bioinformatics (Oxford, England)
Zhang, Y. and Sun, H. and Mandava, A. and Aevermann, B.D. and Kollmann, T.R. and Scheuermann, R.H. and Qiu, X. and Qian, Y.
DOI: 10.1093/bioinformatics/btac585
2022

A place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccine
Vaccine
Brook, B. and Schaltz-Buchholzer, F. and Ben-Othman, R. and Kollmann, T. and Amenyogbe, N.
DOI: 10.1016/j.vaccine.2021.03.092
2022

Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro
Cell Reports
Diray-Arce, J. and Angelidou, A. and Jensen, K.J. and Conti, M.G. and Kelly, R.S. and Pettengill, M.A. and Liu, M. and van Haren, S.D. and McCulloch, S.D. and Michelloti, G. and Idoko, O. and Kollmann, T.R. and Kampmann, B. and Steen, H. and Ozonoff, A. and Lasky-Su, J. and Benn, C.S. and Levy, O.
DOI: 10.1016/j.celrep.2022.110772
2022

Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice
Vaccine
Stevens, N.E. and van Wolfswinkel, M. and Bao, W. and Ryan, F.J. and Brook, B. and Amenyogbe, N. and Marshall, H.S. and Lynn, M.A. and Kollmann, T.R. and Tumes, D.J. and Lynn, D.J.
DOI: 10.1016/j.vaccine.2021.03.084
2022

Immunological mechanisms of vaccine-induced protection against COVID-19 in humans
Nature Reviews Immunology
Manish Sadarangani and Arnaud Marchant and Tobias R. Kollmann
DOI: 10.1038/s41577-021-00578-z
08/2021

Biogeography of the Relationship between the Child Gut Microbiome and Innate Immune System.
mBio
Amenyogbe N and Dimitriu P and Smolen KK and Brown EM and Shannon CP and Tebbutt SJ and Cooper PJ and Marchant A and Goetghebuer T and Esser M and Finlay BB and Kollmann TR and Mohn WW
DOI: 10.1128/mbio.03079-20
PubMed: 33436437
01/2021

Bacterial and Fungal Gut Community Dynamics Over the First 5 Years of Life in Predominantly Rural Communities in Ghana
Frontiers in Microbiology
Amenyogbe, N. and Adu-Gyasi, D. and Enuameh, Y. and Asante, K.P. and Konadu, D.G. and Kaali, S. and Dosoo, D. and Panigrahi, P. and Kollmann, T.R. and Mohn, W.W. and Owusu-Agyei, S.
DOI: 10.3389/fmicb.2021.664407
2021

FastMix: A versatile multi-omics data integration pipeline for cell type-specific biomarker inference
medRxiv
Zhang, Y. and Sun, H. and Mandava, A. and Aevermann, B.D. and Kollmann, T.R. and Scheuermann, R.H. and Qiu, X. and Qian, Y.
DOI: 10.1101/2021.09.14.21263182
2021

Machine learning-based single cell and integrative analysis reveals that baseline mDC predisposition predicts protective Hepatitis B vaccine response
medRxiv
Aevermann, B. and Shannon, C.P. and Novotny, M. and Ben-Othman, R. and Cai, B. and Zhang, Y. and Ye, J.C. and Kobor, M.S. and Gladish, N. and Lee, A. and Blimke, T.M. and Hancock, R.E. and Llibre, A. and Duffy, D. and Koff, W.C. and Sadarangani, M. and Tebbutt, S.J. and Kollmann, T.R. and Scheuermann, R.H.
DOI: 10.1101/2021.02.22.21251864
2021

Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vitro and in vivo
medRxiv
Diray-Arce, J. and Angelidou, A. and Jensen, K.J. and Conti, M.G. and Kelly, R.S. and Pettengill, M.A. and Liu, M. and van Haren, S.D. and McCulloch, S. and Michelloti, G. and Kollmann, T. and Kampmann, B. and Steen, H. and Ozonoff, A. and Lasky-Su, J. and Benn, C.S. and Levy, O.
DOI: 10.1101/2021.12.03.21267251
2021

A cluster randomized trial of interferon ß-1a for the reduction of transmission of SARS-Cov-2: protocol for the Containing Coronavirus Disease 19 trial (ConCorD-19)
BMC Infectious Diseases
Iturriaga, C. and Eiffler, N. and Aniba, R. and Ben-Othman, R. and Perez-Mateluna, G. and Meyer, J.K.V. and Fish, E.N. and Kollmann, T.R. and Severino, N. and Stick, S. and Borzutzky, A. and Perret, C. and Castro-Rodriguez, J.A. and Garcia-Huidobro, D.
DOI: 10.1186/s12879-021-06519-4
2021

Listeriosis in infants: Prospective surveillance studies in Canada and Switzerland
Paediatrics and Child Health (Canada)
Abu-Raya, B. and Jost, M. and Bettinger, J.A. and Bortolussi, R. and Grabowski, J. and Lacaze-Masmonteil, T. and Robinson, J.L. and Posfay-Barbe, K.M. and Galanis, E. and Schutt, E. and Mäusezahl, M. and Kollmann, T.R.
DOI: 10.1093/pch/pxab035
2021

Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life
Cytokine
Smolen, K.K. and Plotkin, A.L. and Shannon, C.P. and Idoko, O.T. and Pak, J. and Darboe, A. and van Haren, S. and Amenyogbe, N. and Tebbutt, S.J. and Kollmann, T.R. and Kampmann, B. and Ozonoff, A. and Levy, O. and Odumade, O.A.
DOI: 10.1016/j.cyto.2021.155704
2021

Biogeography of the relationship between the child gut microbiome and innate immune system
mBio
Amenyogbe, N. and Dimitriu, P. and Smolen, K.K. and Brown, E.M. and Shannon, C.P. and Tebbutt, S.J. and Cooper, P.J. and Marchant, A. and Goetghebuer, T. and Esser, M. and Finlay, B.B. and Kollmann, T.R. and Mohn, W.W.
DOI: 10.1128/mBio.03079-20
2021

One vaccine for life: Lessons from immune ontogeny
Journal of Paediatrics and Child Health
Brophy-Williams, S. and Fidanza, M. and Marchant, A. and Way, S. and Kollmann, T.R.
DOI: 10.1111/jpc.15511
2021

Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response
Frontiers in Immunology
Aevermann, B.D. and Shannon, C.P. and Novotny, M. and Ben-Othman, R. and Cai, B. and Zhang, Y. and Ye, J.C. and Kobor, M.S. and Gladish, N. and Lee, A.H.-Y. and Blimkie, T.M. and Hancock, R.E. and Llibre, A. and Duffy, D. and Koff, W.C. and Sadarangani, M. and Tebbutt, S.J. and Kollmann, T.R. and Scheuermann, R.H.
DOI: 10.3389/fimmu.2021.690470
2021

The Fifth International Neonatal and Maternal Immunization Symposium (INMIS 2019): Securing Protection for the Next Generation
mSphere
Sadarangani, M. and Kollmann, T. and Bjornson, G. and Heath, P. and Clarke, E. and Marchant, A. and Levy, O. and Leuridan, E. and Ulloa-Gutierrez, R. and Cutland, C.L. and Kampmann, B. and Chaithongwongwatthana, S. and Dinleyici, E. and Damme, P.V. and Munoz, F.M.
DOI: 10.1128/MSPHERE.00862-20
2021

Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells
bioRxiv
Zhu, Y. and Chew, K.Y. and Karawita, A.C. and Yamamoto, A. and Labzin, L.L. and Yarlagadda, T. and Khromykh, A.A. and Stocks, C.J. and Xia, Y. and Kollmann, T.R. and Martino, D. and Kicic, A. and Joensuu, M. and Meunier, F.A. and Balistreri, G. and Bielefeldt-Ohmann, H. and Bowen, A.C. and Sly, P.D. and Spann, K.M. and Short, K.R.
DOI: 10.1101/2021.03.08.434300
2021

Immediate Bacille Calmette-Guérin Vaccination to Neonates Requiring Perinatal Treatment at the Maternity Ward in Guinea-Bissau: A Randomized Controlled Trial
Journal of Infectious Diseases
Schaltz-Buchholzer, F. and Aaby, P. and Monteiro, I. and Camala, L. and Faurholt Simonsen, S. and N?rtoft Frankel, H. and Lindberg Larsen, K. and Golding, C.N. and Kollmann, T.R. and Amenyogbe, N. and Stabell Benn, C. and Bjerregaard-Andersen, M.
DOI: 10.1093/infdis/jiab220
2021

Searching for a technology-driven acute rheumatic fever test: The START study protocol
BMJ Open
Ralph, A.P. and Webb, R. and Moreland, N.J. and McGregor, R. and Bosco, A. and Broadhurst, D. and Lassmann, T. and Barnett, T.C. and Benothman, R. and Yan, J. and Remenyi, B. and Bennett, J. and Wilson, N. and Mayo, M. and Pearson, G. and Kollmann, T. and Carapetis, J.R.
DOI: 10.1136/bmjopen-2021-053720
2021

Lactiplantibacillus plantarum–Nomad and Ideal Probiotic
Frontiers in Microbiology
Fidanza, M. and Panigrahi, P. and Kollmann, T.R.
DOI: 10.3389/fmicb.2021.712236
2021

BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial)
BMJ Open
Pittet, L.F. and Messina, N.L. and Gardiner, K. and Orsini, F. and Abruzzo, V. and Bannister, S. and Bonten, M. and Campbell, J.L. and Croda, J. and Dalcolmo, M. and Elia, S. and Germano, S. and Goodall, C. and Gwee, A. and Jamieson, T. and Jardim, B. and Kollmann, T.R. and Lacerda, M.V.G. and Lee, K.J. and Legge, D. and Lucas, M. and Lynn, D.J. and McDonald, E. and Manning, L. and Munns, C.F. and Perrett, K.P. and Prat Aymerich, C. and Richmond, P. and Shann, F. and Sudbury, E. and Villanueva, P. and Wood, N.J. and Lieschke, K. and Subbarao, K. and Davidson, A. and Curtis, N.
DOI: 10.1136/bmjopen-2021-052101
2021

Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life
Frontiers in Immunology
Odumade, O.A. and Plotkin, A.L. and Pak, J. and Idoko, O.T. and Pettengill, M.A. and Kollmann, T.R. and Ozonoff, A. and Kampmann, B. and Levy, O. and Smolen, K.K.
DOI: 10.3389/fimmu.2021.578700
2021

Corrigendum: Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea.
Frontiers in pediatrics
Idoko OT and Smolen KK and Wariri O and Imam A and Shannon CP and Dibassey T and Diray-Arce J and Darboe A and Strandmark J and Ben-Othman R and Odumade OA and McEnaney K and Kampmann B
DOI: 10.3389/fped.2020.610461
PubMed: 33313031
11/2020

Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults.
Frontiers in immunology
Ben-Othman R and Cai B and Liu AC and Varankovich N and He D and Blimkie TM and Lee AH and Gill EE and Novotny M and Aevermann B and Drissler S and Shannon CP and McCann S and Marty K and Sadarangani M
DOI: 10.3389/fimmu.2020.580373
PubMed: 33250895
11/2020

Innate Immune Responses and Gut Microbiomes Distinguish HIV-Exposed from HIV-Unexposed Children in a Population-Specific Manner.
Journal of immunology (Baltimore, Md. : 1950)
Amenyogbe N and Dimitriu P and Cho P and Ruck C and Fortuno ES and Cai B and Alimenti A and Côté HCF and Maan EJ and Slogrove AL and Esser M and Marchant A and Goetghebuer T and Smolen KK
DOI: 10.4049/jimmunol.2000040
PubMed: 33067377
10/2020

Corrigendum: Interferon-a2b Treatment for COVID-19.
Frontiers in immunology
Zhou Q and Chen V and Shannon CP and Wei XS and Xiang X and Wang X and Wang ZH and Tebbutt SJ and Kollmann TR and Fish EN
DOI: 10.3389/fimmu.2020.615275
PubMed: 33193462
10/2020

Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life
Frontiers in Immunology
Tue Bjerg Bennike and Benoit Fatou and Asimenia Angelidou and Joann Diray-Arce and Reza Falsafi and Rebecca Ford and Erin E. Gill and Simon D. van Haren and Olubukola T. Idoko and Amy H. Lee and Rym Ben-Othman and William S. Pomat and Casey P. Shannon and Kinga K. Smolen and Scott J. Tebbutt and Al Ozonoff and Peter C. Richmond and Anita H. J. van den Biggelaar and Robert E. W. Hancock and Beate Kampmann and Tobias R. Kollmann and Ofer Levy and Hanno Steen
DOI: 10.3389/fimmu.2020.578505
10/2020

Bacterial and Fungal Gut Community Dynamics Over the First Five Years of Life in Predominantly Rural Communities in Ghana
Amenyogbe NA and Adu-Gyasi D and Enuameh Y and Asante KP and Konadu DG and Seyram K and Dosoo D and Panigrahi P and Kollmann T and Mohn W and Owusu-Agyei S
DOI: 10.21203/rs.3.rs-78160/v1
09/2020

The non-specific and sex-differential effects of vaccines
Nature Reviews Immunology
Peter Aaby and Christine Stabell Benn and Katie L. Flanagan and Sabra L. Klein and Tobias R. Kollmann and David J. Lynn and Frank Shann
DOI: 10.1038/s41577-020-0338-x
08/2020

Immunogenicity of 2 and 3 Doses of the Quadrivalent Human Papillomavirus Vaccine up to 120 Months Postvaccination: Follow-up of a Randomized Clinical Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Donken R and Dobson SRM and Marty KD and Cook D and Sauvageau C and Gilca V and Dionne M and McNeil S and Krajden M and Money D and Kellner J and Scheifele DW and Kollmann T and Ogilvie GS
DOI: 10.1093/cid/ciz887
PubMed: 31617568
08/2020

Feasibility of manual white blood cell counts as a predictor of neonatal sepsis in a low-resource setting.
Transactions of the Royal Society of Tropical Medicine and Hygiene
Golding CN and Schaltz-Buchholzer F and Sanca L and Clipet-Jensen C and Benn CS and Au N and Chipperfield K and Kollmann TR and Amenyogbe NA
DOI: 10.1093/trstmh/traa023
PubMed: 32333010
08/2020

Profiling avidity of antibodies elicited by vaccination using enzyme-linked immunosorbent assay-based elution – Insights into a novel experimental and analytical approach
Vaccine
Bahaa Abu-Raya and Michelle L Giles and Tobias R. Kollmann and Manish Sadarangani
DOI: 10.1016/j.vaccine.2020.06.060
07/2020

Association of Maternal Factors and HIV Infection With Innate Cytokine Responses of Delivering Mothers and Newborns in Mozambique.
Frontiers in microbiology
Moncunill G and Dobaño C and González R and Smolen KK and Manaca MN and Balcells R and Jairoce C and Cisteró P and Vala A and Sevene E and Rupérez M and Aponte JJ and Macete E and Mayor A
DOI: 10.3389/fmicb.2020.01452
PubMed: 32765436
07/2020

Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?
Trends in Immunology
John S. Tsang and Carlota Dobaño and Pierre VanDamme and Gemma Moncunill and Arnaud Marchant and Rym Ben Othman and Manish Sadarangani and Wayne C. Koff and Tobias R. Kollmann
DOI: 10.1016/j.it.2020.04.001
06/2020

Neonatal BCG Vaccination Reduces Interferon-¿ Responsiveness to Heterologous Pathogens in Infants From a Randomized Controlled Trial.
The Journal of infectious diseases
Freyne B and Messina NL and Donath S and Germano S and Bonnici R and Gardiner K and Casalaz D and Robins-Browne RM and Netea MG and Flanagan KL and Kollmann T and Curtis N and Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR) Group
DOI: 10.1093/infdis/jiaa030
PubMed: 31990350
06/2020

Vaccination strategies to enhance immunity in neonates
Science
Tobias R. Kollmann and Arnaud Marchant and Sing Sing Way
DOI: 10.1126/science.aaz9447
05/2020

Maternal HIV Infection Alters Antimicrobial Immunity in Exposed and Uninfected Infants.
The Pediatric infectious disease journal
Marchant A and Amenyogbe N and Kollmann TR and Goetghebuer T
DOI: 10.1097/inf.0000000000002614
PubMed: 32301922
05/2020

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.
Science translational medicine
Brook B and Harbeson DJ and Shannon CP and Cai B and He D and Ben-Othman R and Francis F and Huang J and Varankovich N and Liu A and Bao W and Bjerregaard-Andersen M and Amenyogbe N
DOI: 10.1126/scitranslmed.aax4517
PubMed: 32376769
05/2020

Interferon-a2b Treatment for COVID-19.
Frontiers in immunology
Zhou Q and Chen V and Shannon CP and Wei XS and Xiang X and Wang X and Wang ZH and Tebbutt SJ and Kollmann TR and Fish EN
DOI: 10.3389/fimmu.2020.01061
PubMed: 32574262
05/2020

Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea.
Frontiers in pediatrics
Idoko OT and Smolen KK and Wariri O and Imam A and Shannon CP and Dibassey T and Diray-Arce J and Darboe A and Strandmark J and Ben-Othman R and Odumade OA and McEnaney K and Kampmann B
DOI: 10.3389/fped.2020.00197
PubMed: 32426309
04/2020

Interferon-a2b treatment for COVID-19
Zhou Q and Wei X and Xiang X and Wang X and Wang Z and Chen V and Shannon CP and Tebbutt SJ and Kollmann TR and Fish EN
DOI: 10.1101/2020.04.06.20042580
04/2020

Bacterial and Fungal Gut Community Dynamics Over the First Five Years of Life in Predominantly Rural Communities in Ghana
ResearchSquare
Amenyogbe, N.A. and Adu-Gyasi, D. and Enuameh, Y. and Asante, K.P. and Konadu, D.G. and Seyram, K. and Dosoo, D. and Panigrahi, P. and Kollmann, T. and Mohn, W. and Owusu-Agyei, S.
DOI: 10.21203/rs.3.rs-78160
2020

Maternal HIV infection alters antimicrobial immunity in exposed and uninfected infants
Pediatric Infectious Disease Journal
Marchant, A. and Amenyogbe, N. and Kollmann, T.R. and Goetghebuer, T.
DOI: 10.1097/INF.0000000000002614
2020

Measles Maternal Antibodies With Low Avidity Do Not Interfere With the Establishment of Robust Quantity and Quality Antibody Responses After the Primary Dose of Measles, Mumps, and Rubella Vaccine Administered at 12-Months of Age
Journal of the Pediatric Infectious Diseases Society
Collins, C.A. and Gelinas, L. and Yasukawa, L.L. and Audet, S. and Abu-Raya, B. and Turvey, S.E. and Beeler, J.A. and Kollmann, T.R. and Gans, H.A.
DOI: 10.1093/jpids/piz074
2020

A teenager with migrating leg pains and anemia
Pediatrics in Review
Eckbo, E.J. and Mijovic, H. and Rathgeber, S. and Armstrong, K. and Kollmann, T.R.
DOI: 10.1542/pir.2018-0042
2020

Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small Cohort
Frontiers in Immunology
Shannon, C.P. and Blimkie, T.M. and Ben-Othman, R. and Gladish, N. and Amenyogbe, N. and Drissler, S. and Edgar, R.D. and Chan, Q. and Krajden, M. and Foster, L.J. and Kobor, M.S. and Mohn, W.W. and Brinkman, R.R. and Le Cao, K.-A. and Scheuermann, R.H. and Tebbutt, S.J. and Hancock, R.E.W. and Koff, W.C. and Kollmann, T.R. and Sadarangani, M. and Lee, A.H.-Y.
DOI: 10.3389/fimmu.2020.578801
2020

Biological sex influences antibody responses to routine vaccinations in the first year of life
Acta Paediatrica, International Journal of Paediatrics
Zimmermann, P. and Perrett, K.P. and Ritz, N. and Flanagan, K.L. and Robins-Browne, R. and van der Klis, F.R.M. and Curtis, N. and Abruzzo, V. and Allen, K. and Bonnici, R. and Casalaz, D. and Elborough, H. and Freyne, B. and Gardiner, K. and Germano, S. and Kollmann, T. and Messina, N. and Morrison, C. and Nakaya, H. and Ponsonby, A.L. and Shann, F. and South, M. and Vuillermin, P.
DOI: 10.1111/apa.14932
2020

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis
Science Translational Medicine
Brook, B. and Harbeson, D.J. and Shannon, C.P. and Cai, B. and He, D. and Ben-Othman, R. and Francis, F. and Huang, J. and Varankovich, N. and Liu, A. and Bao, W. and Bjerregaard-Andersen, M. and Schaltz-Buchholzer, F. and Sanca, L. and Golding, C.N. and Larsen, K.L. and Levy, O. and Kampmann, B. and Tan, R. and Charles, A. and Wynn, J.L. and Shann, F. and Aaby, P. and Benn, C.S. and Tebbutt, S.J. and Kollmann, T.R. and Amenyogbe, N. and Lee, A.H. and Bennike, T.B. and Diray-Arce, J. and Idoko, O. and Pomat, W.S. and van Haren, S. and Cox, M. and Darboe, A. and Falsafi, R. and Hinshaw, S.H. and Ndure, J. and Njie-Jobe, J. and Pettengill, M.A. and Marchant, A. and Richmond, P.C. and Ford, R. and Saleu, G. and Masiria, G. and Matlam, J.P. and Kirarock, W. and Roberts, E. and Malek, M. and Sanchez-Schmitz, G. and Singh, A. and Angelidou, A. and Smolen, K.K. and Brinkman, R.R. and Ozonoff, A. and Hancock, R.E.W. and van den Biggelaar, A.H.J. and Steen, H. and Vo, D. and Kraft, K. and McEnaney, K. and Vignolo, S.
DOI: 10.1126/SCITRANSLMED.AAX4517
2020

The Effect of Timing of Tetanus-Diphtheria-Acellular Pertussis Vaccine Administration in Pregnancy on the Avidity of Pertussis Antibodies.
Frontiers in immunology
Abu-Raya B and Giles ML and Kollmann TR and Sadarangani M
DOI: 10.3389/fimmu.2019.02423
PubMed: 31681310
10/2019

AIDS Vaccine Research Subcommittee (AVRS) Consultation: Early-Life Immunization Strategies against HIV Acquisition.
mSphere
Singh A and Permar S and Kollmann TR and Levy O and Marovich M and De Paris K
DOI: 10.1128/mSphere.00320-19
PubMed: 31315966
07/2019

Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency.
Journal of leukocyte biology
Monajemi M and Fisk S and Pang YCF and Leung J and Menzies SC and Ben-Othman R and Cai B and Kollmann TR and Rozmus J and Sly LM
DOI: 10.1002/jlb.5vma0219-054r
PubMed: 31313375
07/2019

Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization.
The Journal of allergy and clinical immunology
Cait A and Cardenas E and Dimitriu P and Amenyogbe N and Dai D and Cait J and Sbihi H and Stiemsma L and Subbarao P and Mandhane PJ and Becker AB and Moraes TJ and Sears MR and Mohn WW
DOI: 10.1016/j.jaci.2019.06.029
PubMed: 31279007
07/2019

Robust health-score based survival prediction for a neonatal mouse model of polymicrobial sepsis.
PloS one
Brook B and Harbeson D and Amenyogbe N and Ben-Othman R and Kollmann TR and Aniba R
DOI: 10.1371/journal.pone.0218714
PubMed: 31233529
06/2019

Reply to Slogrove et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Goetghebuer T and Smolen KK and Adler C and Das J and McBride T and Smits G and Lecomte S and Haelterman E and Barlow P and Piedra PA and Van der Klis F and Kollmann TR and Marchant A
DOI: 10.1093/cid/ciy1058
PubMed: 30535371
05/2019

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.
Nature communications
Lee AH and Shannon CP and Amenyogbe N and Bennike TB and Diray-Arce J and Idoko OT and Gill EE and Ben-Othman R and Pomat WS and van Haren SD and Cao KL and Cox M and Darboe A and Kollmann TR
DOI: 10.1038/s41467-019-08794-x
PubMed: 30862783
03/2019

Initiation of Antiretroviral Therapy Before Pregnancy Reduces the Risk of Infection-related Hospitalization in Human Immunodeficiency Virus-exposed Uninfected Infants Born in a High-income Country.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Goetghebuer T and Smolen KK and Adler C and Das J and McBride T and Smits G and Lecomte S and Haelterman E and Barlow P and Piedra PA and van der Klis F and Kollmann TR and Marchant A
DOI: 10.1093/cid/ciy673
PubMed: 30215689
03/2019

Prenatal depression and birth mode sequentially mediate maternal education's influence on infant sleep duration.
Sleep medicine
Matenchuk BA and Tamana SK and Lou WYW and Lefebvre DL and Sears MR and Becker AB and Azad MB and Moraes TJ and Turvey SE and Subbarao P and Kozyrskyj AL and Mandhane PJ and CHILD Study Investigators
DOI: 10.1016/j.sleep.2019.01.015
PubMed: 31153013
01/2019

Probiotic Studies in Neonatal Mice Using Gavage.
Journal of visualized experiments : JoVE
Francis F and Varankovich N and Brook B and Amenyogbe N and Ben-Othman R and Cai B and Harbeson D and Liu AC and Dai B and McErlane S and Andrews K and Kollmann TR and Panigrahi P
DOI: 10.3791/59074
PubMed: 30741256
01/2019

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis.
Journal of visualized experiments : JoVE
Brook B and Amenyogbe N and Ben-Othman R and Cai B and Harbeson D and Francis F and Liu AC and Varankovich N and Wynn J and Kollmann TR
DOI: 10.3791/58574
PubMed: 30741260
01/2019

Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency
Journal of Leukocyte Biology
Monajemi, M. and Fisk, S. and Pang, Y.C.F. and Leung, J. and Menzies, S.C. and Ben-Othman, R. and Cai, B. and Kollmann, T.R. and Rozmus, J. and Sly, L.M.
DOI: 10.1002/JLB.5VMA0219-054R
2019

Residential green space and pathways to term birth weight in the Canadian Healthy Infant Longitudinal Development (CHILD) Study.
International journal of health geographics
Cusack L and Sbihi H and Larkin A and Chow A and Brook JR and Moraes T and Mandhane PJ and Becker AB and Azad MB and Subbarao P and Kozyrskyj A and Takaro TK and Sears MR and Turvey SE and CHILD Study Investigators
DOI: 10.1186/s12942-018-0160-x
PubMed: 30514315
12/2018

153. The Effect of Timing of Tetanus–Diphtheria and Pertussis Vaccine Administration in Pregnancy on The Avidity of Pertussis Antibodies.
Open forum infectious diseases
Raya BA and Giles M and Kollmann T and Sadarangani M
DOI: 10.1093/ofid/ofy209.023
11/2018

Predicting the Atopic March: Results From the Canadian Healthy Infant Longitudinal Development Study
Pediatrics
Jennifer A. Dantzer and Robert A. Wood
DOI: 10.1542/peds.2018-2420n
11/2018

Diagnosing atopic dermatitis in infancy: Questionnaire reports vs criteria-based assessment.
Paediatric and perinatal epidemiology
Dharma C and Lefebvre DL and Tran MM and Lu Z and Lou WYW and Subbarao P and Becker AB and Mandhane PJ and Turvey SE and Moraes TJ and Azad MB and Sears MR and CHILD Study Investigators
DOI: 10.1111/ppe.12525
PubMed: 30461044
11/2018

Energy Demands of Early Life Drive a Disease Tolerant Phenotype and Dictate Outcome in Neonatal Bacterial Sepsis.
Frontiers in immunology
Harbeson D and Francis F and Bao W and Amenyogbe NA and Kollmann TR
DOI: 10.3389/fimmu.2018.01918
PubMed: 30190719
08/2018

Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life
JAMA Pediatrics
DOI: 10.1001/jamapediatrics.2018.1161
07/2018

Outgrowing the Immaturity Myth: The Cost of Defending From Neonatal Infectious Disease.
Frontiers in immunology
Harbeson D and Ben-Othman R and Amenyogbe N and Kollmann TR
DOI: 10.3389/fimmu.2018.01077
PubMed: 29896192
05/2018

Neonatal BCG Vaccination Influences Cytokine Responses to Toll-like Receptor Ligands and Heterologous Antigens.
The Journal of infectious diseases
Freyne B and Donath S and Germano S and Gardiner K and Casalaz D and Robins-Browne RM and Amenyogbe N and Messina NL and Netea MG and Flanagan KL and Kollmann T and Curtis N
DOI: 10.1093/infdis/jiy069
PubMed: 29415180
05/2018

Innate immune responses following Kawasaki disease and toxic shock syndrome.
PloS one
Chen KYH and Messina N and Germano S and Bonnici R and Freyne B and Cheung M and Goldsmith G and Kollmann TR and Levin M and Burgner D and Curtis N
DOI: 10.1371/journal.pone.0191830
PubMed: 29447181
02/2018

Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn.
Frontiers in immunology
Scheid A and Borriello F and Pietrasanta C and Christou H and Diray-Arce J and Pettengill MA and Joshi S and Li N and Bergelson I and Kollmann T and Dowling DJ and Levy O
DOI: 10.3389/fimmu.2018.00029
PubMed: 29416539
01/2018

Traumatic Neonatal Lumbar Punctures: Experience at a Large Pediatric Tertiary Care Center in Canada
American Journal of Perinatology
Matettore, A. and Kollmann, T.R.
DOI: 10.1055/s-0037-1615794
2018

The Western environment reduces innate immune cytokine production in Chinese immigrants
Journal of Allergy and Clinical Immunology
Saiganesh, A. and Hales, B.J. and Chen, S. and Filipovska-Naumovska, E. and Pereira, G. and Garand, M. and Kollmann, T.R. and Currie, A.J. and Le Souëf, P.N. and Zhang, G.
DOI: 10.1016/j.jaci.2017.11.031
2018

Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study
Journal of Allergy and Clinical Immunology
Tran, M.M. and Lefebvre, D.L. and Dharma, C. and Dai, D. and Lou, W.Y.W. and Subbarao, P. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Sears, M.R. and Anand, S.S. and Azad, M. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M. and Daley, D. and Dell, S.D. and Denburg, J.A. and Duan, Q. and Eiwegger, T. and Grasemann, H. and HayGlass, K. and Hegele, R.G. and Holness, D.L. and Hystad, P. and Kobor, M. and Kollmann, T.R. and Kozyrskyj, A.L. and Laprise, C. and Macri, J. and Miller, G. and Moraes, T.J. and Paré, P. and Ramsey, C. and Ratjen, F. and Sandford, A. and Scott, J.A. and Scott, J. and Silverman, F. and Simons, E. and Takaro, T. and Tebbutt, S. and To, T.
DOI: 10.1016/j.jaci.2017.08.024
2018

Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases
Clinical and Experimental Allergy
Dharma, C. and Lefebvre, D.L. and Tran, M.M. and Lou, W.Y.W. and Subbarao, P. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Sears, M.R. and Anand, S.S. and Azad, M.B. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M.M. and Daley, D. and Dell, S.D. and Denburg, J.A. and Duan, Q.L. and Eiwegger, T. and Grasemann, H. and HayGlass, K. and Hegele, R.G. and Holness, D.L. and Hystad, P. and Kobor, M. and Kollmann, T.R. and Kozyrskyj, A.L. and Laprise, C. and Macri, J. and Miller, G. and Moraes, T.J. and Paré, P. and Ramsey, C. and Ratjen, F. and Sandford, A. and Scott, J.A. and Scott, J. and Silverman, F. and Simons, E. and Takaro, T. and Tebbutt, S.J. and To, T.
DOI: 10.1111/cea.13063
2018

Case-control study of household contacts to examine immunological protection from Bordetella pertussis transmission - study protocol.
CMAJ open
Bolotin S and Johnson C and Quach S and Ambrose A and DeCoutere S and Deeks SL and Drews S and Faheem A and Green K and Halperin SA and Hoang L and Jamieson F and Kollmann T and Canadian Immunization Research Network Provincial Collaborative Network
DOI: 10.9778/cmajo.20170072
PubMed: 29269437
12/2017

Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study.
The Journal of pediatrics
DOI: 10.1016/j.jpeds.2017.07.012
PubMed: 29144244
11/2017

Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen.
Seminars in immunopathology
DOI: 10.1007/s00281-017-0651-z
PubMed: 29098373
11/2017

Immunity and immunopathology in early human life.
Seminars in immunopathology
DOI: 10.1007/s00281-017-0657-6
PubMed: 29170801
11/2017

Cellular immune responses of older adults to four influenza vaccines: Results of a randomized, controlled comparison.
Human vaccines & immunotherapeutics
DOI: 10.1080/21645515.2017.1337615
PubMed: 28635557
09/2017

Timing of food introduction and development of food sensitization in a prospective birth cohort.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
DOI: 10.1111/pai.12739
PubMed: 28557044
08/2017

Maternal immunisation: collaborating with mother nature.
The Lancet. Infectious diseases
DOI: 10.1016/s1473-3099(17)30229-3
PubMed: 28433705
07/2017

Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios.
Microbiome
DOI: 10.1186/s40168-017-0254-x
PubMed: 28381231
04/2017

OMIP-038: Innate immune assessment with a 14 color flow cytometry panel.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Smolen KK and Cai B and Kollmann TR
DOI: 10.1002/cyto.a.23109
PubMed: 28419701
04/2017

Lack of broad functional differences in immunity in fully vaccinated vs. unvaccinated children.
Pediatric research
DOI: 10.1038/pr.2016.272
PubMed: 28024144
04/2017

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny.
Immunity
DOI: 10.1016/j.immuni.2017.03.009
PubMed: 28329702
03/2017

A Prospective Cohort Study of Common Childhood Infections in South African HIV-exposed Uninfected and HIV-unexposed Infants.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0000000000001391
PubMed: 28081048
02/2017

Environment impacts innate immune ontogeny.
Innate immunity
DOI: 10.1177/1753425916671018
PubMed: 27697850
01/2017

Host Defense Mechanisms Against Bacteria
Fetal and Neonatal Physiology
Tobias R. Kollmann and Arnaud Marchant
DOI: 10.1016/b978-0-323-35214-7.00120-7
2017

Early-Life Host-Microbiome Interphase: The Key Frontier for Immune Development.
Frontiers in Pediatrics
DOI: 10.3389/fped.2017.00111
PubMed: 28596951
2017

Editorial: Immune Mechanisms Underlying the Increased Morbidity and Mortality of HIV-Exposed Uninfected (HEU) Children.
Frontiers in Immunology
DOI: 10.3389/fimmu.2017.01060
PubMed: 28932223
2017

Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy.
Frontiers in pediatrics
DOI: 10.3389/fped.2017.00200
PubMed: 29018787
2017

Host Defense Mechanisms Against Bacteria
Fetal and Neonatal Physiology, 2-Volume Set
Kollmann, T.R. and Marchant, A.
DOI: 10.1016/B978-0-323-35214-7.00120-7
2017

Maternal immunisation: collaborating with mother nature
The Lancet Infectious Diseases
Marchant, A. and Sadarangani, M. and Garand, M. and Dauby, N. and Verhasselt, V. and Pereira, L. and Bjornson, G. and Jones, C.E. and Halperin, S.A. and Edwards, K.M. and Heath, P. and Openshaw, P.J. and Scheifele, D.W. and Kollmann, T.R.
DOI: 10.1016/S1473-3099(17)30229-3
2017

Sex-specific impact of asthma during pregnancy on infant gut microbiota
European Respiratory Journal
Koleva, P.T. and Tun, H.M. and Konya, T. and Guttman, D.S. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Sears, M.R. and Scott, J.A. and Kozyrskyj, A.L. and Anand, S.S. and Azad, M.B. and Becker, A.B. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M.M. and Daley, D. and Dell, S.D. and Denburg, J.A. and Duan, Q.L. and Eiwegger, T. and Grasemann, H. and HayGlass, K. and Hegele, R.G. and Holness, D.L. and Hystad, P. and Kobor, M. and Kollmann, T.R. and Laprise, C. and Lou, W.Y.W. and Macri, J. and Mandhane, P.J. and Miller, G. and Moraes, T.J. and Paré, P. and Ramsey, C. and Ratjen, F. and Sandford, A. and Scott, J. and Scott, J.A. and Sears, M.R. and Silverman, F. and Simons, E. and Subbarao, P. and Takaro, T. and Tebbutt, S.J. and To, T. and Turvey, S.E.
DOI: 10.1183/13993003.00280-2017
2017

A Prospective cohort study of common childhood infections in South African HIV-exposed uninfected and HIV-unexposed infants
Pediatric Infectious Disease Journal
Slogrove, A.L. and Esser, M.M. and Cotton, M.F. and Speert, D.P. and Kollmann, T.R. and Singer, J. and Bettinger, J.A.
DOI: 10.1097/INF.0000000000001391
2017

Hepatitis B Virus Vaccine–Induced Cell-Mediated Immunity Correlates with Humoral Immune Response following Primary Vaccination during Infancy
ImmunoHorizons
Gelinas, L. and Abu-Raya, B. and Ruck, C. and Cai, B. and Kollmann, T.R.
DOI: 10.4049/immunohorizons.1700015
2017

Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells.
Biomaterials
DOI: 10.1016/j.biomaterials.2016.09.032
PubMed: 27728817
12/2016

Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma.
Clinical science (London, England : 1979)
DOI: 10.1042/cs20160349
PubMed: 27634868
12/2016

Towards Predicting Protective Vaccine Responses in the Very Young.
Trends in immunology
DOI: 10.1016/j.it.2016.05.005
PubMed: 27344245
08/2016

Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Côté M and Boulay M and Plante S and Chakir J and Boulet L and Ahmed H and Ospina M and Sideri K and Vliagoftis H and Johnson SF and Woodgate RL and Cros G and Teira P and Cellot S and Conway EM
08/2016

Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index.
JAMA pediatrics
DOI: 10.1001/jamapediatrics.2016.0301
PubMed: 27159792
07/2016

Harnessing the beneficial heterologous effects of vaccination.
Nature reviews. Immunology
DOI: 10.1038/nri.2016.43
PubMed: 27157064
06/2016

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
BJOG : an international journal of obstetrics and gynaecology
DOI: 10.1111/1471-0528.13601
PubMed: 26412384
05/2016

Changing oral vaccine to inactivated polio vaccine might increase mortality.
Lancet (London, England)
DOI: 10.1016/s0140-6736(16)00661-9
PubMed: 27025182
03/2016

Infant gut immunity: a preliminary study of IgA associations with breastfeeding.
Journal of developmental origins of health and disease
DOI: 10.1017/s2040174415007862
PubMed: 26690933
02/2016

Changing oral vaccine to inactivated polio vaccine might increase mortality
The Lancet
Fish, E.N. and Flanagan, K.L. and Furman, D. and Klein, S.L. and Kollmann, T.R. and Jeppesen, D.L. and Levy, O. and Marchant, A. and Namachivayam, S. and Netea, M.G. and Plebanski, M. and Rowland-Jones, S.L. and Selin, L.K. and Shann, F. and Whittle, H.C.
DOI: 10.1016/S0140-6736(16)00661-9
2016

Linking Susceptibility to Infectious Diseases to Immune System Abnormalities among HIV-Exposed Uninfected Infants.
Frontiers in immunology
DOI: 10.3389/fimmu.2016.00310
PubMed: 27594857
2016

Transfer of Maternal Antimicrobial Immunity to HIV-Exposed Uninfected Newborns.
Frontiers in Immunology
DOI: 10.3389/fimmu.2016.00338
PubMed: 27630640
2016

The Immune System of HIV-Exposed Uninfected Infants.
Frontiers in immunology
PubMed: 27733852
2016

The immune system of HIV-exposed uninfected infants
Frontiers in Immunology
Abu-Raya, B. and Kollmann, T.R. and Marchant, A. and MacGillivray, D.M.
DOI: 10.3389/fimmu.2016.00383
2016

Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma
Clinical Science
Stiemsma, L.T. and Arrieta, M.-C. and Dimitriu, P.A. and Cheng, J. and Thorson, L. and Lefebvre, D.L. and Azad, M.B. and Subbarao, P. and Mandhane, P. and Becker, A. and Sears, M.R. and Kollmann, T.R. and Mohn, W.W. and Finlay, B.B. and Turvey, S.E.
DOI: 10.1042/CS20160349
2016

Attenuated innate immune defenses in very premature neonates during the neonatal period.
Pediatric research
DOI: 10.1038/pr.2015.132
PubMed: 26186294
11/2015

MicroResearch in East Africa: Opportunities for Addressing Gender Inequity.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
DOI: 10.1016/s1701-2163(16)30025-1
PubMed: 26606704
10/2015

The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.
Thorax
DOI: 10.1136/thoraxjnl-2015-207246
PubMed: 26069286
10/2015

Early infancy microbial and metabolic alterations affect risk of childhood asthma.
Science translational medicine
DOI: 10.1126/scitranslmed.aab2271
PubMed: 26424567
09/2015

Amino Acid-Dependent Attenuation of Toll-like Receptor Signaling by Peptide-Gold Nanoparticle Hybrids.
ACS nano
DOI: 10.1021/nn505634h
PubMed: 26083966
07/2015

MicroResearch--Finding sustainable solutions to local health challenges in East Africa.
The Journal of infection
DOI: 10.1016/j.jinf.2015.04.022
PubMed: 25934328
06/2015

Development of immunity in early life.
The Journal of infection
DOI: 10.1016/j.jinf.2015.04.027
PubMed: 25934325
06/2015

Systems vaccinology: a promise for the young and the poor.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
DOI: 10.1098/rstb.2014.0340
PubMed: 25964462
06/2015

Probiotics to prevent early-life infection.
The Lancet. Infectious diseases
DOI: 10.1016/s1473-3099(15)70088-5
PubMed: 25809893
04/2015

Infant gut microbiota and food sensitization: associations in the first year of life.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
DOI: 10.1111/cea.12487
PubMed: 25599982
03/2015

BCG modulates neonatal innate immune cytokine production.
The Journal of infectious diseases
DOI: 10.1093/infdis/jiu509
PubMed: 25210138
03/2015

The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking.
Paediatric and perinatal epidemiology
DOI: 10.1111/ppe.12161
PubMed: 25405552
01/2015

The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures.
Journal of exposure science & environmental epidemiology
DOI: 10.1038/jes.2015.7
PubMed: 25805254
2015

Understanding the ontogeny of the immune system to promote immune-mediated health for life.
Frontiers in immunology
DOI: 10.3389/fimmu.2015.00077
PubMed: 25755655
2015

Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults.
PloS one
DOI: 10.1371/journal.pone.0132061
PubMed: 26147648
2015

The author responds
Paediatrics and Child Health (Canada)
Mang'Oli, P. and Kollmann, T.
DOI: 10.1093/pch/20.3.148a
2015

Probiotics to prevent early-life infection
The Lancet Infectious Diseases
Strunk, T. and Kollmann, T. and Patole, S.
DOI: 10.1016/S1473-3099(15)70088-5
2015

MicroResearch in East Africa: Opportunities for Addressing Gender Inequity
Journal of Obstetrics and Gynaecology Canada
Arkell, C. and MacPhail, C. and Abdalla, S. and Grant, E. and Ashaba, S. and Bii, L.C. and Bienempaka, F. and Pemba, S. and Kollmann, T. and Bortolussi, R. and MacDonald, N.E.
DOI: 10.1016/S1701-2163(16)30025-1
2015

Ponseti clubfoot management: Experience with the Steenbeek foot abduction brace.
Paediatrics & child health
DOI: 10.1093/pch/19.10.513
PubMed: 25587223
12/2014

Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges.
Nature immunology
DOI: 10.1038/ni.2961
PubMed: 25232810
10/2014

Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.1400895
PubMed: 25135829
09/2014

Altered innate immune development in HIV-exposed uninfected infants.
Journal of acquired immune deficiency syndromes (1999)
DOI: 10.1097/qai.0000000000000161
PubMed: 24732876
07/2014

Perinatal Immunization With Vaccine-Grade Listeria monocytogenes Provides Protection Against Murine Th2 Airway Inflammation.
Allergy, asthma & immunology research
DOI: 10.4168/aair.2014.6.4.341
PubMed: 24991458
07/2014

Maturation of innate responses to mycobacteria over the first nine months of life.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.1400062
PubMed: 24733845
05/2014

Associations between bacterial communities of house dust and infant gut.
Environmental research
DOI: 10.1016/j.envres.2014.02.005
PubMed: 24637181
05/2014

Case 2: A nine-year-old girl with prolonged fever and headache.
Paediatrics & child health
DOI: 10.1093/pch/19.4.177a
PubMed: 24855412
04/2014

Topical CpG adjuvantation of a protein-based vaccine induces protective immunity to Listeria monocytogenes.
Clinical and vaccine immunology : CVI
DOI: 10.1128/cvi.00734-13
PubMed: 24391136
03/2014

Pattern recognition receptor-mediated cytokine response in infants across 4 continents.
The Journal of allergy and clinical immunology
DOI: 10.1016/j.jaci.2013.09.038
PubMed: 24290283
03/2014

Assessment of HPV 16 and HPV 18 antibody responses by pseudovirus neutralization, Merck cLIA and Merck total IgG LIA immunoassays in a reduced dosage quadrivalent HPV vaccine trial.
Vaccine
DOI: 10.1016/j.vaccine.2013.09.007
PubMed: 24055350
01/2014

Listeria monocytogenes: a promising vehicle for neonatal vaccination.
Human vaccines & immunotherapeutics
DOI: 10.4161/hv.27999
PubMed: 24513715
2014

Harnessing microbiome and probiotic research in sub-Saharan Africa: recommendations from an African workshop.
Microbiome
DOI: 10.1186/2049-2618-2-12
PubMed: 24739094
2014

The role of environmental factors in modulating immune responses in early life.
Frontiers in immunology
DOI: 10.3389/fimmu.2014.00434
PubMed: 25309535
2014

The early life gut microbiota and atopic disease.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
DOI: 10.1186/1710-1492-10-s2-a63
2014

The early life gut microbiota and atopic disease
Allergy, Asthma and Clinical Immunology
Stiemsma, L.T. and Arrieta, M.-C. and Dimitriu, P.A. and Thorson, L. and Yurist, S. and Brandt, R. and Lefebvre, D.L. and Subbarao, P. and Mandhane, P. and Becker, A. and Sears, M. and Kollmann, T. and Mohn, W.W. and Finlay, B.B. and Turvey, S.E. and the CHILD Study Investigators
DOI: 10.1186/1710-1492-10-S2-A63
2014

Altered innate immune development in HIV-exposed uninfected infants
Journal of Acquired Immune Deficiency Syndromes
Reikie, B.A. and Adams, R.C.M. and Leligdowicz, A. and Ho, K. and Naidoo, S. and Ruck, C.E. and De Beer, C. and Preiser, W. and Cotton, M.F. and Speert, D.P. and Esser, M. and Kollmann, T.R.
DOI: 10.1097/QAI.0000000000000161
2014

Topical CpG adjuvantation of a protein-based vaccine induces protective immunity to Listeria monocytogenes
Clinical and Vaccine Immunology
Cheng, W.K. and Wee, K. and Kollmann, T.R. and Dutz, J.P.
DOI: 10.1128/CVI.00734-13
2014

Recurrent subacute post-viral onset of ataxia associated with a PRF1 mutation.
European journal of human genetics : EJHG
DOI: 10.1038/ejhg.2013.20
PubMed: 23443029
11/2013

Clostridium difficile vertebral osteomyelitis.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e318296b424
PubMed: 23594589
09/2013

Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine.
The Journal of biological chemistry
DOI: 10.1074/jbc.m113.484212
PubMed: 23897810
09/2013

Elevated inflammatory mediators in adults with oculorespiratory syndrome following influenza immunization: a public health agency of Canada/Canadian Institutes of Health Research Influenza Research Network Study.
Clinical and vaccine immunology : CVI
DOI: 10.1128/cvi.00659-12
PubMed: 23697573
08/2013

Implications of Age-Dependent Immune Responses to Enterovirus 71 Infection for Disease Pathogenesis and Vaccine Design.
Journal of the Pediatric Infectious Diseases Society
DOI: 10.1093/jpids/pit017
PubMed: 26619463
06/2013

Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates.
Genes and immunity
DOI: 10.1038/gene.2013.5
PubMed: 23466493
06/2013

Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial.
JAMA
DOI: 10.1001/jama.2013.1625
PubMed: 23632723
05/2013

Immune response to vaccine adjuvants during the first year of life.
Vaccine
DOI: 10.1016/j.vaccine.2012.10.016
PubMed: 23085363
05/2013

Vaccine-induced immunity in early life.
Vaccine
DOI: 10.1016/j.vaccine.2013.04.025
PubMed: 23588085
05/2013

Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.1201015
PubMed: 23487427
04/2013

Unusual patterns of IgG avidity in some young children following two doses of the adjuvanted pandemic H1N1 (2009) influenza virus vaccine.
Clinical and vaccine immunology : CVI
DOI: 10.1128/cvi.00619-12
PubMed: 23345582
04/2013

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
DOI: 10.1503/cmaj.121189
PubMed: 23401405
03/2013

Critical assessment of automated flow cytometry data analysis techniques.
Nature methods
DOI: 10.1038/nmeth.2365
PubMed: 23396282
03/2013

Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life.
Clinical and vaccine immunology : CVI
DOI: 10.1128/cvi.00557-12
PubMed: 23114697
01/2013

Critical assessment of automated flow cytometry data analysis techniques
Nature Methods
Aghaeepour, N. and Finak, G. and Hoos, H. and Mosmann, T.R. and Brinkman, R. and Gottardo, R. and Scheuermann, R.H. and Dougall, D. and Khodabakhshi, A.H. and Mah, P. and Obermoser, G. and Spidlen, J. and Taylor, I. and Wuensch, S.A. and Bramson, J. and Eaves, C. and Weng, A.P. and Fortuno III, E.S. and Ho, K. and Kollmann, T.R. and Rogers, W. and De Rosa, S. and Dalai, B. and Azad, A. and Pothen, A. and Brandes, A. and Bretschneider, H. and Bruggner, R. and Finck, R. and Jia, R. and Zimmerman, N. and Linderman, M. and Dill, D. and Nolan, G. and Chan, C. and Khettabi, F.E. and O'Neill, K. and Chikina, M. and Ge, Y. and Sealfon, S. and Sugár, I. and Gupta, A. and Shooshtari, P. and Zare, H. and De Jager, P.L. and Jiang, M. and Keilwagen, J. and Maisog, J.M. and Luta, G. and Barbo, A.A. and Májek, P. and Vil?ek, J. and Manninen, T. and Huttunen, H. and Ruusuvuori, P. and Nykter, M. and McLachlan, G.J. and Wang, K. and Naim, I. and Sharma, G. and Nikolic, R. and Pyne, S. and Qian, Y. and Qiu, P. and Quinn, J. and Roth, A. and Meyer, P. and Stolovitzky, G. and Saez-Rodriguez, J. and Norel, R. and Bhattacharjee, M. and Biehl, M. and Bucher, P. and Bunte, K. and Di Camillo, B. and Sambo, F. and Sanavia, T. and Trifoglio, E. and Toffolo, G. and Slavica Dimitrieva, S.D. and Dreos, R. and Ambrosini, G. and Grau, J. and Grosse, I. and Posch, S. and Guex, N. and Kursa, M. and Rudnicki, W. and Liu, B. and Maienschein-Cline, M. and Schneider, P. and Seifert, M. and Strickert, M. and Vilar, J.M.G.
DOI: 10.1038/NMETH.2365
2013

Variation between Populations in the Innate Immune Response to Vaccine Adjuvants.
Frontiers in immunology
DOI: 10.3389/fimmu.2013.00081
PubMed: 23565115
2013

Age-dependent differences in systemic and cell-autonomous immunity to L. monocytogenes.
Clinical and Developmental Immunology
DOI: 10.1155/2013/917198
PubMed: 23653659
2013

Host defense against common early life-threatening infections.
Clinical and Developmental Immunology
DOI: 10.1155/2013/350808
PubMed: 24093045
2013

Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life
Clinical and Vaccine Immunology
Reikie, B.A. and Naidoo, S. and Ruck, C.E. and Slogrove, A.L. and De Beer, C. and La Grange, H. and Adams, R.C.M. and Ho, K. and Smolen, K. and Speert, D.P. and Cotton, M.F. and Preiser, W. and Esser, M. and Kollmann, T.R.
DOI: 10.1128/CVI.00557-12
2013

Clostridium difficile vertebral osteomyelitis
Pediatric Infectious Disease Journal
Al-Najjar, A. and Al-Rawahi, G.N. and Hoang, L.M. and Kollmann, T.R.
DOI: 10.1097/INF.0b013e318296b424
2013

Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine
Journal of Biological Chemistry
Pettengill, M. and Robson, S. and Tresenriter, M. and Millán, J.L. and Usheva, A. and Bingham, T. and Belderbos, M. and Bergelson, I. and Burl, S. and Kampmann, B. and Gelinas, L. and Kollmann, T. and Bont, L. and Levy, O.
DOI: 10.1074/jbc.M113.484212
2013

Elevated inflammatory mediators in adults with oculorespiratory syndrome following influenza immunization: A public health agency of Canada/Canadian institutes of health research influenza research network study
Clinical and Vaccine Immunology
Al-Dabbagh, M. and Lapphra, K. and Scheifele, D.W. and Halperin, S.A. and Langley, J.M. and Cho, P. and Kollmann, T.R. and Li, Y. and De Serres, G. and Fortuno III, E.S. and Bettinger, J.A.
DOI: 10.1128/CVI.00659-12
2013

HIV-exposed uninfected infants are at increased risk for severe infections in the first year of life.
Journal of tropical pediatrics
DOI: 10.1093/tropej/fms019
PubMed: 22555385
12/2012

Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly.
Immunity
DOI: 10.1016/j.immuni.2012.10.014
PubMed: 23159225
11/2012

Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination.
Vaccine
DOI: 10.1016/j.vaccine.2012.03.051
PubMed: 22469863
05/2012

Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study.
Vaccine
DOI: 10.1016/j.vaccine.2012.03.046
PubMed: 22469860
05/2012

Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections.
The Lancet. Infectious diseases
DOI: 10.1016/s1473-3099(11)70341-3
PubMed: 22364680
04/2012

Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
PubMed: 22498276
02/2012

Optimization of a whole blood intracellular cytokine assay for measuring innate cell responses to mycobacteria.
Journal of immunological methods
DOI: 10.1016/j.jim.2011.11.011
PubMed: 22155193
02/2012

GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults.
The Journal of infectious diseases
DOI: 10.1093/infdis/jir769
PubMed: 22147791
02/2012

Management of multi-drug-resistant tuberculosis in children
European Infectious Disease
Al-Dabbagh, M. and Driessche, K.V. and Marais, B.J. and Kollmann, T.R.
2012

Management of Multidrug-resistant Tuberculosis (MDR-TB) in Children
European Infectious Disease Journal
2012

Primary peritonitis due to group A Streptococcus in a previously healthy pediatric patient.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
DOI: 10.1155/2012/105850
PubMed: 23997789
2012

An eight-month-old child with cervical adenitis.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
DOI: 10.1155/2012/318463
PubMed: 23997784
2012

Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.
PloS one
DOI: 10.1371/journal.pone.0044763
PubMed: 23028609
2012

Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.
PLoS Pathogens
DOI: 10.1371/journal.ppat.1002963
PubMed: 23071439
2012

Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant
Journal of Otolaryngology - Head and Neck Surgery
Tan, N.W.H. and Turvey, S.E. and Byrne, A.T. and Ludemann, J.P. and Kollmann, T.R.
DOI: 10.2310/7070.2011.110136
2012

Uninfected but not unaffected: Chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections
The Lancet Infectious Diseases
Dauby, N. and Goetghebuer, T. and Kollmann, T.R. and Levy, J. and Marchant, A.
DOI: 10.1016/S1473-3099(11)70341-3
2012

Drug-resistant tuberculosis: pediatric guidelines.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e31820b583d
PubMed: 21297522
06/2011

Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation.
Journal of immunological methods
DOI: 10.1016/j.jim.2011.01.009
PubMed: 21277305
03/2011

Facilitating the analysis of immunological data with visual analytic techniques.
Journal of visualized experiments : JoVE
DOI: 10.3791/2397
PubMed: 21248691
01/2011

Flow cytometry data standards
BMC Research Notes
Spidlen, J. and Shooshtari, P. and Kollmann, T.R. and Brinkman, R.R.
DOI: 10.1186/1756-0500-4-50
2011

Congenital Syphilis
Infectious Diseases of the Fetus and Newborn
Tobias R. Kollmann and Simon Dobson
DOI: 10.1016/b978-1-4160-6400-8.00016-x
2011

Syphilis
Infectious Diseases of the Fetus and Newborn Infant
Kollmann, T.R. and Dobson, S.
DOI: 10.1016/B978-1-4160-6400-8.00016-X
2011

Drug-resistant tuberculosis: Pediatric guidelines
Pediatric Infectious Disease Journal
Al-Dabbagh, M. and Lapphra, K. and McGloin, R. and Inrig, K. and Schaaf, H.S. and Marais, B.J. and Sauve, L. and Kitai, I. and Kollmann, T.R.
DOI: 10.1097/INF.0b013e31820b583d
2011

A single immunization near birth elicits immediate and lifelong protective immunity.
Vaccine
DOI: 10.1016/j.vaccine.2010.10.013
PubMed: 21034825
12/2010

Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis.
The Journal of infectious diseases
DOI: 10.1086/657143
PubMed: 20977341
12/2010

Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells.
PloS one
DOI: 10.1371/journal.pone.0015041
PubMed: 21152080
11/2010

Correlation analysis of intracellular and secreted cytokines via the generalized integrated mean fluorescence intensity.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
DOI: 10.1002/cyto.a.20943
PubMed: 20629196
09/2010

Identification of B cells through negative gating-An example of the MIFlowCyt standard applied.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
DOI: 10.1002/cyto.a.20862
PubMed: 20131398
06/2010

Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
DOI: 10.1186/1710-1492-6-s3-p2
2010

A bacterial immune-prophylactic approach against asthma for infants and children.
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
DOI: 10.1186/1710-1492-6-s3-p20
2010

Syphilis
Infectious Diseases of the Fetus and Newborn: Expert Consult - Online and Print
Kollmann, T.R. and Dobson, S.
DOI: 10.1016/B978-1-4160-6400-8/00016-X
2010

Neonatal innate TLR-mediated responses are distinct from those of adults.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.0901481
PubMed: 19917677
12/2009

Neonatal immunization with Listeria monocytogenes induces T cells with an adult-like avidity, sensitivity, and TCR-Vbeta repertoire, and does not adversely impact the response to boosting.
Vaccine
DOI: 10.1016/j.vaccine.2009.09.091
PubMed: 19796722
12/2009

Rhabdomyolysis, acute renal failure, and compartment syndrome in a child with parainfluenza type 1 infection.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e3181a33522
PubMed: 19684526
09/2009

Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells.
Molecular bioSystems
DOI: 10.1039/b813787k
PubMed: 19381363
05/2009

Fine-tuning the safety and immunogenicity of Listeria monocytogenes-based neonatal vaccine platforms.
Vaccine
DOI: 10.1016/j.vaccine.2008.11.047
PubMed: 19059297
02/2009

Anaerobic brain abscess following chronic suppurative otitis media in a child from Uganda.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
DOI: 10.1155/2009/407139
PubMed: 20808460
2009

MIFlowCyt: the minimum information about a Flow Cytometry Experiment.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
DOI: 10.1002/cyto.a.20623
PubMed: 18752282
10/2008

Polychromatic flow cytometric high-throughput assay to analyze the innate immune response to Toll-like receptor stimulation.
Journal of immunological methods
DOI: 10.1016/j.jim.2008.04.013
PubMed: 18565537
07/2008

Induction of antigen-specific immunity in human neonates and infants
Nestle Nutrition Workshop Series: Pediatric Program
Wilson, C. and Kollmann, T.
DOI: 10.1159/000113493
2008

Imported fatal hantavirus pulmonary syndrome.
Emerging Infectious Diseases
DOI: 10.3201/eid1309.070708
PubMed: 18252129
09/2007

Induction of protective immunity to Listeria monocytogenes in neonates.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.178.6.3695
PubMed: 17339467
03/2007

Deficient MHC class I cross-presentation of soluble antigen by murine neonatal dendritic cells.
Blood
DOI: 10.1182/blood-2003-11-3805
PubMed: 14982880
06/2004

Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity.
Cellular microbiology
DOI: 10.1046/j.1462-5822.2004.00360.x
PubMed: 14764107
03/2004

Cutting edge: protective cell-mediated immunity to Listeria monocytogenes in the absence of myeloid differentiation factor 88.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.171.2.533
PubMed: 12847214
07/2003

Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system?
Pediatrics
DOI: 10.1542/peds.109.1.124
PubMed: 11773551
01/2002

Purified protein derivative anergy in Kawasaki disease.
The Pediatric infectious disease journal
DOI: 10.1097/00006454-200101000-00018
PubMed: 11176575
01/2001

thy/liv-SCID-hu mice: a system for investigating the in vivo effects of multidrug therapy on plasma viremia and human immunodeficiency virus replication in lymphoid tissues.
The Journal of infectious diseases
DOI: 10.1086/514214
PubMed: 9466519
02/1998

Thy/Liv-SCID-Hu mice implanted with human intestine: an in vivo model for investigation of mucosal transmission of HIV.
AIDS research and human retroviruses
DOI: 10.1089/aid.1997.13.1453
PubMed: 9390744
11/1997

Saquinavir-mediated inhibition of human immunodeficiency virus (HIV) infection in SCID mice implanted with human fetal thymus and liver tissue: an in vivo model for evaluating the effect of drug therapy on HIV infection in lymphoid tissues.
Antimicrobial agents and chemotherapy
PubMed: 9303378
09/1997

Severe combined immunodeficiency mice engrafted with human T cells, B cells, and myeloid cells after transplantation with human fetal bone marrow or liver cells and implanted with human fetal thymus: a model for studying human gene therapy.
Blood
PubMed: 9057666
03/1997

Saquinavir-mediated inhibition of human immunodeficiency virus (HIV) infection in SCID mice implanted with human fetal thymus and liver tissue: An in vivo model for evaluating the effect of drug therapy on HIV infection in lymphoid tissues
Antimicrobial Agents and Chemotherapy
Pettoello-Mantovani, M. and Kollmann, T.R. and Raker, C. and Kim, A. and Yurasov, S. and Tudor, R. and Wiltshire, H. and Goldstein, H.
DOI: 10.1128/aac.41.9.1880
1997

Severe combined lmmunodeficiency mice engrafted with human T cells, B cells, and myeloid cells after transplantation with human fetal bone marrow or liver cells and implanted with human fetal thymus: A model for studying human gene therapy
Blood
Yurasov, S. and Kollmann, T.R. and Kim, A. and Raker, C.A. and Hachamovitch, M. and Wong-Staal, F. and Goldstein, H.
DOI: 10.1182/blood.v89.5.1800
1997

SCID-hu mice: a model for studying disseminated HIV infection.
Seminars in immunology
DOI: 10.1006/smim.1996.0028
PubMed: 8883145
08/1996

Inhibition of acute in vivo human immunodeficiency virus infection by human interleukin 10 treatment of SCID mice implanted with human fetal thymus and liver.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.93.7.3126
PubMed: 8610180
04/1996

In vivo studies on retrovirally mediated gene transfer into fetal hematopoietic stem/precursor cells
Experimental Hematology
Yurasov, S. and Kollmann, T. and Raker, C. and Kirn, A. and GoIdstein, H.
1996

Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice.
Journal of immunology (Baltimore, Md. : 1950)
PubMed: 7814892
01/1995

Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice
Journal of Immunology
Kollmann, T.R. and Kim, A. and Pettoello-Mantovani, M. and Hachamovitch, M. and Rubinstein, A. and Goldstein, M.M. and Goldstein, H.
1995

Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.91.17.8032
PubMed: 7914701
08/1994

Disseminated human immunodeficiency virus 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1.
The Journal of experimental medicine
DOI: 10.1084/jem.179.2.513
PubMed: 8294863
02/1994

The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system.
The Journal of experimental medicine
DOI: 10.1084/jem.177.3.821
PubMed: 8436912
03/1993

Design of polymerase chain reaction primers for the selective amplification of HIV-1 RNA in the presence of HIV-1 DNA.
AIDS (London, England)
PubMed: 1388875
06/1992

Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans.
Lancet (London, England)
DOI: 10.1016/0140-6736(92)90142-p
PubMed: 1370335
01/1992

Design of polymerase chain reaction primers for the selective amplification of HIV-1 RNA in the presence of HIV-1 DNA
AIDS
Kollmann, T.R. and Zhuangt, X. and Rubinstein, A. and Goldstein, H.
DOI: 10.1097/00002030-199206000-00004
1992

Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans
The Lancet
Pettoello-Mantovani, M. and Rubinstein, A. and Goldstein, H. and Casadevall, A. and Kollmann, T.R. and Rubinstein, A. and Goldstein, H. and Casadevall, A.
DOI: 10.1016/0140-6736(92)90142-P
1992

Inhibition of HIV-1 infection by alkylureas.
AIDS (London, England)
PubMed: 1726039
12/1991

Characterization of IgG and IgG subclass antibodies present in paired maternal and fetal serum which are directed against HIV-1 proteins.
AIDS research and human retroviruses
DOI: 10.1089/aid.1991.7.847
PubMed: 1742077
10/1991

Inhibition of HIV-1 infection by alkylureas
AIDS
Goldstein, H. and Pettoello-Mantovani, M. and Kollmann, T.R. and Calvelli, T.A. and Rubinstein, A.
DOI: 10.1097/00002030-199112000-00006
1991

Research

Current Projects
Our lab uses state-of-the-art wet-lab technology and bioinformatic approaches (systems biology) to get the most information out of the smallest samples from newborns and infants around the world. Parallel to these obervational human cohort studies, we are developing in vitro (culture) and in vivo (animal) models where we establish concrete cause & effect of the relationships identified in our systems biological studies. This combined approach allows us to systematically dissect the key cellular and molecular mechanisms important in the human neonatal and infant response to infection or vaccination. Based on that knowledge, we are identifying immune modulators that help protect newborns from disease, and aid in their immune response to vaccines important for global health. This work is done in close collaboration with several large national (e.g. CHILD) and international research groups from Africa and Asia, to Europe, North America and Australia.

Honours & Awards

Michael Smith Foundation for Health Research Career Investigator Award

Burroughs Wellcome Career Award in the Biomedical Sciences

Canadian Child Health Clinician Scientist Career Development Award

Research Group Members

Mandy Lo, Research Assistant