Overview

Overall Research Goals

To further understand the determinants of outcome from concussion and more serious brain injuries

To advance brain imaging in psychiatric and neurological disorders

To better understand the factors leading to social decline and homelessness in Vancouver’s downtown eastside population

Primary Research Techniques

Advanced neuroimaging, primarily cutting edge MRI techniques

Neurocognitive and psychiatric assessments, both manual and computerized

Publications

Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada.
PLoS medicine
Jones AA and Gicas KM and Seyedin S and Willi TS and Leonova O and Vila-Rodriguez F and Procyshyn RM and Smith GN and Schmitt TA and Vertinsky AT and Buchanan T and Rauscher A and Honer WG
DOI: 10.1371/journal.pmed.1003172
PubMed: 32628679
07/2020

Amygdala Nuclei Volumes Are Selectively Associated With Social Network Size in Homeless and Precariously Housed Persons.
Frontiers in behavioral neuroscience
Jones PW and Thornton AE and Jones AA and Knerich VM and Lang DJ and Woodward ML and Panenka WJ and Su W and Barr AM and Buchanan T and Honer WG and Gicas KM
DOI: 10.3389/fnbeh.2020.00097
PubMed: 32612516
06/2020

M216. ASSOCIATIONS OF EXTRAPYRAMIDAL SYMPTOMS WITH PSYCHOTIC SYMPTOMS IN A COHORT OF HOMELESS OR PRECARIOUSLY HOUSED PERSONS WITH OR WITHOUT SCHIZOPHRENIA.
Schizophrenia bulletin
Kim D and Procyshyn R and Hang Lee L and Panenka W and Leonova O and Honer W and Barr A
05/2020

Traumatic Brain Injury: An Underappreciated Determinant of Health in Individuals Who are Homeless or Precariously Housed.
World neurosurgery
Stubbs JL and Thornton AE and Silverberg ND and Sevick JM and Barr AM and Honer WG and Panenka WJ
DOI: 10.1016/j.wneu.2020.02.133
PubMed: 32365435
05/2020

Cognitive decline and mortality in a community-based sample of homeless and precariously housed adults: 9-year prospective study.
BJPsych open
Gicas KM and Jones AA and Thornton AE and Petersson A and Livingston E and Waclawik K and Panenka WJ and Barr AM and Lang DJ and Vila-Rodriguez F and Leonova O and Procyshyn RM and Honer WG
DOI: 10.1192/bjo.2020.3
PubMed: 32043436
02/2020

Atypical Somatic Symptoms in Adults With Prolonged Recovery From Mild Traumatic Brain Injury.
Frontiers in neurology
Stubbs JL and Green KE and Silverberg ND and Howard A and Dhariwal AK and Brubacher JR and Garraway N and Heran MKS and Sekhon MS and Aquino A and Purcell V and Hutchison JS and Panenka WJ
DOI: 10.3389/fneur.2020.00043
PubMed: 32117012
02/2020

Myelin water fraction decrease in mild traumatic brain injury
Russell-Schulz B and Vavasour I and Zhang J and MacKay AL and Purcell V and Muller AM and Brucar L and Torres IJ and Panenka W and Virji-Babul N
DOI: 10.1101/2020.02.05.934430
02/2020

Traumatic brain injury in homeless and marginally housed individuals: a systematic review and meta-analysis.
The Lancet. Public health
Stubbs JL and Thornton AE and Sevick JM and Silverberg ND and Barr AM and Honer WG and Panenka WJ
DOI: 10.1016/s2468-2667(19)30188-4
PubMed: 31806487
12/2019

Characterization of mental health in cannabis dispensary users, using structured clinical interviews and standardized assessment instruments.
BMC psychiatry
Yau JC and Yu SM and Panenka WJ and Pearce H and Gicas KM and Procyshyn RM and MacCallum C and Honer WG and Barr AM
DOI: 10.1186/s12888-019-2324-z
PubMed: 31675939
11/2019

Management of Concussion and Mild Traumatic Brain Injury: A Synthesis of Practice Guidelines.
Archives of physical medicine and rehabilitation
Silverberg ND and Iaccarino MA and Panenka WJ and Iverson GL and McCulloch KL and Dams-O'Connor K and Reed N and McCrea M and American Congress of Rehabilitation Medicine Brain Injury Interdisciplinary Special Interest Group Mild TBI Task Force
DOI: 10.1016/j.apmr.2019.10.179
PubMed: 31654620
10/2019

Cognitive Impairment in Marginally Housed Youth: Prevalence and Risk Factors.
Frontiers in public health
Waclawik K and Jones AA and Barbic SP and Gicas KM and O'Connor TA and Smith GN and Leonova O and Mathias S and Barr AM and Procyshyn RM and Lang DJ and Woodward ML and MacEwan GW and Thornton AE
DOI: 10.3389/fpubh.2019.00270
PubMed: 31649909
10/2019

Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada.
PloS one
Knerich V and Jones AA and Seyedin S and Siu C and Dinh L and Mostafavi S and Barr AM and Panenka WJ and Thornton AE and Honer WG and Rutherford AR
DOI: 10.1371/journal.pone.0222611
PubMed: 31545818
09/2019

Characterizing traumatic brain injury and its association with homelessness in a community-based sample of precariously housed adults and youth
Stubbs JL and Thornton AE and Gicas KM and O'Connor TA and Livingston EM and Lu HY and Mehta AK and Lang DJ and Vertinsky AT and Field TS and Heran MK and Leonova O and Buchanan T and Panenka WJ
DOI: 10.1101/19004606
08/2019

Atypical somatic symptoms in adults with prolonged recovery from mild traumatic brain injury
Stubbs JL and Green KE and Silverberg ND and Howard A and Dhariwal A and Brubacher JR and Garraway N and Heran MKS and Sekhon MS and Aquino A and Purcell V and Hutchison JS and CTRC (Canadian traumatic brain injury research...)
DOI: 10.1101/19004622
08/2019

Prevalence and Risk Factors of Brain Infarcts and Associations With Cognitive Performance in Tenants of Marginal Housing
Journal of the American Heart Association
Lily W. Zhou and William J. Panenka and Andrea A. Jones and Kristina M. Gicas and Allen E. Thornton and Manraj K. S. Heran and David Volders and Donna J. Lang and Alexandra Talia Vertinsky and Alexander Rauscher and Wayne Su and Alasdair M. Barr and Gordon William MacEwan and William G. Honer and Thalia S. Field
DOI: 10.1161/jaha.118.011412
07/2019

Preseason Vestibular Ocular Motor Screening in Children and Adolescents
Clinical Journal of Sport Medicine
Grant L. Iverson and Nathan E. Cook and David R. Howell and Laurel J. Collings and Cody Kusch and Jonathan Sun and Naznin Virji-Babul and William J. Panenka
DOI: 10.1097/jsm.0000000000000767
06/2019

A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia
Psychopharmacology
Peter D. Alexander and Kristina M. Gicas and Alex Cheng and Donna J. Lang and Ric M. Procyshyn and Alexandra T. Vertinsky and William J. Panenka and Allen E. Thornton and Alexander Rauscher and Jamie Y. X. Wong and Tasha Chan and Andrea A. Jones and F. Vila-Rodriguez and William G. Honer and Alasdair M. Barr
DOI: 10.1007/s00213-019-05298-w
06/2019

Cognitive profiles and associated structural brain networks in a multimorbid sample of marginalized adults
PLOS ONE
Kristina M. Gicas and Andrea A. Jones and William J. Panenka and Chantelle Giesbrecht and Donna J. Lang and Fidel Vila-Rodriguez and Olga Leonova and Alasdair M. Barr and Ric M. Procyshyn and Wayne Su and Alexander Rauscher and A. Talia Vertinsky and Tari Buchanan and G. William MacEwan and Allen E. Thornton and William G. Honer
DOI: 10.1371/journal.pone.0218201
06/2019

Headache Trigger Sensitivity and Avoidance after Mild Traumatic Brain Injury
Journal of Neurotrauma
Noah D. Silverberg and Paul Martin and William J. Panenka
DOI: 10.1089/neu.2018.6025
05/2019

Returning to Activity After a Concussion
Archives of Physical Medicine and Rehabilitation
Nick Reed and Noah D. Silverberg and Mary Alexis Iaccarino and Michael McCrea and Karen L. McCulloch and William Panenka and Emma Gregory and Kristen Dams-O’Connor and Grant L. Iverson and Chris Weyer Jamora and Heather Belanger and Gary McKinney and Alison M. Cogan and Christine Provvidenza
DOI: 10.1016/j.apmr.2018.11.022
04/2019

Antidepressants for depression after concussion and traumatic brain injury are still best practice
BMC Psychiatry
Noah D. Silverberg and William J. Panenka
DOI: 10.1186/s12888-019-2076-9
03/2019

Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing
Brain and Behavior
Kristina M. Gicas and Alex Cheng and Iris Rawtaer and Taylor S. Willi and William J. Panenka and Donna J. Lang and Geoff N. Smith and Fidel Vila-Rodriguez and Olga Leonova and Chantelle J. Giesbrecht and Andrea A. Jones and Alasdair M. Barr and Ric M. Procyshyn and Tari Buchanan and G. William MacEwan and Wayne Su and Alexandra T. Vertinsky and Alexander Rauscher and Norm O’Rourke and Wendy Loken Thornton and Allen E. Thornton and William G. Honer
DOI: 10.1002/brb3.1233
02/2019

Working memory load improves diagnostic performance of smooth pursuit eye movement in mild traumatic brain injury patients with protracted recovery
Scientific Reports
Jacob L. Stubbs and Sherryse L. Corrow and Benjamin R. Kiang and Jeffrey C. Corrow and Hadley L. Pearce and Alex Y. Cheng and Jason J. S. Barton and William J. Panenka
DOI: 10.1038/s41598-018-36286-3
01/2019

Volumes of the Hippocampal Formation Differentiate Component Processes of Memory in a Community Sample of Homeless and Marginally Housed Persons
Archives of Clinical Neuropsychology
Kristina M Gicas and Allen E Thornton and Kristina Waclawik and Nena Wang and Andrea A Jones and William J Panenka and Donna J Lang and Geoff N Smith and Fidel Vila-Rodriguez and Olga Leonova and Alasdair M Barr and Ric M Procyshyn and Tari Buchanan and Wayne Su and Alexandra T Vertinsky and Alexander Rauscher and G William MacEwan and William G Honer
DOI: 10.1093/arclin/acy066
11/2018

Fear Avoidance and Clinical Outcomes from Mild Traumatic Brain Injury
Journal of Neurotrauma
Noah D. Silverberg and William J. Panenka and Grant L. Iverson
DOI: 10.1089/neu.2018.5662
08/2018

Workplace and non-workplace mild traumatic brain injuries in an outpatient clinic sample: A case-control study
PLOS ONE
Douglas P. Terry and Grant L. Iverson and William Panenka and Angela Colantonio and Noah D. Silverberg
DOI: 10.1371/journal.pone.0198128
06/2018

Effect of depression on cognition after mild traumatic brain injury in adults
The Clinical Neuropsychologist
Douglas P. Terry and Michelle Brassil and Grant L. Iverson and William J. Panenka and Noah D. Silverberg
DOI: 10.1080/13854046.2018.1459853
05/2018

Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study
Canadian Journal of Public Health
Skye P. Barbic and Andrea A. Jones and Melissa Woodward and Matt Piercy and Steve Mathias and Fidel Vila-Rodriguez and Olga Leonova and Geoffrey N. Smith and Tari Buchanan and Alexandra T. Vertinsky and Stephanie Gillingham and William J. Panenka and Alexander Rauscher and Alasdair M. Barr and Ric M. Procyshyn and G. William MacEwan and Donna J. Lang and Allen E. Thornton and Manraj K. Heran and Adelena M. Leon and Michael Krausz and William G. Honer
DOI: 10.17269/s41997-018-0087-9
05/2018

Rapid Change in Fentanyl Prevalence in a Community-Based, High-Risk Sample
JAMA Psychiatry
Andrea A. Jones and Kerry Jang and William J. Panenka and Alasdair M. Barr and G. William MacEwan and Allen E. Thornton and William G. Honer
DOI: 10.1001/jamapsychiatry.2017.4432
03/2018

A Systematic Review of the Usefulness of Glial Fibrillary Acidic Protein for Predicting Acute Intracranial Lesions following Head Trauma.
Frontiers in neurology
DOI: 10.3389/fneur.2017.00652
PubMed: 29255443
12/2017

Preliminary Validation of the World Health Organization Disability Assessment Schedule 2.0 for Mild Traumatic Brain Injury.
Journal of neurotrauma
DOI: 10.1089/neu.2017.5234
PubMed: 28895491
10/2017

Attention-deficit/hyperactivity disorder is associated with baseline child sport concussion assessment tool third edition scores in child hockey players
Brain Injury
Laurel J. Collings and Nathan E. Cook and Shaun Porter and Cody Kusch and Jonathan Sun and Naznin Virji-Babul and Grant L. Iverson and William J. Panenka
DOI: 10.1080/02699052.2017.1377351
09/2017

Cogniphobia in Mild Traumatic Brain Injury
Journal of Neurotrauma
DOI: 10.1089/neu.2016.4719
2017

Traumatic Brain Injury in a Community-Based Cohort of Homeless and Vulnerably Housed Individuals
Journal of Neurotrauma
Toby Schmitt and Allen E. Thornton and Iris Rawtaer and Alasdair M. Barr and Kristina M. Gicas and Donna J. Lang and A. Talia Vertinsky and Alexander Rauscher and Ric M. Procyshyn and Tari Buchanan and Alex Cheng and Sarah MacKay and Olga Leonova and Verena Langheimer and Thalia S. Field and Manraj K. Heran and Fidel Vila-Rodriguez and Tiffany A. O'Connor and G. William MacEwan and William G. Honer and William J. Panenka
DOI: 10.1089/neu.2017.5076
2017

Perceived Injustice and its Correlates after Mild Traumatic Brain Injury
Journal of Neurotrauma
Grant L Iverson and Douglas P Terry and Justin E. Karr and William Panenka and Noah D Silverberg
DOI: 10.1089/neu.2017.5402
2017

The effects of enhanced attention and working memory on smooth pursuit eye movement
Experimental Brain Research
Jacob L. Stubbs and Sherryse L. Corrow and Benjamin Kiang and William J. Panenka and Jason J. S. Barton
DOI: 10.1007/s00221-017-5146-6
2017

Work Productivity Loss After Mild Traumatic Brain Injury
Archives of Physical Medicine and Rehabilitation
DOI: 10.1016/j.apmr.2017.07.006
2017

Systematic Review of Genetic Risk Factors for Sustaining a Mild Traumatic Brain Injury
Journal of Neurotrauma
DOI: 10.1089/neu.2016.4833
2017

Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users
Addiction Biology
DOI: 10.1111/adb.12363
2017

Autoreactivity to sulfatide by human invariant NKT cells
Journal of Immunology
DOI: 10.4049/jimmunol.1601976
2017

Genetics and Other Risk Factors for Past Concussions in Active-Duty Soldiers
Journal of Neurotrauma
DOI: 10.1089/neu.2016.4480
2017

The Hotel Study - Clinical and Health Service Effectiveness in a Cohort of Homeless or Marginally Housed Persons
Canadian Journal of Psychiatry
DOI: 10.1177/0706743717693781
2017

Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness
Neuropsychology
DOI: 10.1037/neu0000304
2017

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence
Psychopharmacology
DOI: 10.1007/s00213-017-4551-7
2017

Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury
Heliyon
DOI: 10.1016/j.heliyon.2017.e00373
2017

Alcohol consumption does not impede recovery from mild to moderate traumatic brain injury
Journal of the International Neuropsychological Society
DOI: 10.1017/S1355617716000692
2016

The positive and negative syndrome scale (PANSS): A three-factor model of psychopathology in marginally housed persons with substance dependence and psychiatric illness
PLoS ONE
DOI: 10.1371/journal.pone.0151648
2016

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Psychiatry Research
DOI: 10.1016/j.psychres.2016.04.059
2016

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users
Schizophrenia Research
DOI: 10.1016/j.schres.2016.08.001
2016

The Child Sport Concussion Assessment Tool (Child SCAT3): normative values and correspondence between child and parent symptom scores in male child athletes
BMJ Open Sport & Exercise Medicine
Shaun Porter and Jenna Smith-Forrester and Najah Alhajri and Cody Kusch and Jonathan Sun and Bill Barrable and William J Panenka and Naznin Virji-Babul
DOI: 10.1136/bmjsem-2015-000029
08/2015

White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection Psychiatry
BMC Research Notes
DOI: 10.1186/s13104-015-1501-5
2015

Diffusion tensor imaging findings and postconcussion symptom reporting six weeks following mild traumatic brain injury
Archives of Clinical Neuropsychology
DOI: 10.1093/arclin/acu060
2015

Systematic review of multivariable prognostic models for mild traumatic brain injury
Journal of Neurotrauma
DOI: 10.1089/neu.2014.3600
2015

Mortality from treatable illnesses in marginally housed adults: A prospective cohort study
BMJ Open
DOI: 10.1136/bmjopen-2015-008876
2015

Neuropsychological outcome and diffusion tensor imaging in complicated versus uncomplicated mild traumatic brain injury
PLoS ONE
DOI: 10.1371/journal.pone.0122746
2015

Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness
Journal of Clinical and Experimental Neuropsychology
DOI: 10.1080/13803395.2014.963519
2014

Prevalence and patterns of antipsychotic use in youth at the time of admission and discharge from an inpatient psychiatric facility
Journal of Clinical Psychopharmacology
DOI: 10.1097/JCP.0b013e3182a607dd
2014

Personalized risk assessment of drug-related harm is associated with health outcomes
PLoS ONE
DOI: 10.1371/journal.pone.0079754
2013

Towards clinical management of traumatic brain injury: A review of models and mechanisms from a biomechanical perspective
DMM Disease Models and Mechanisms
DOI: 10.1242/dmm.011320
2013

The hotel study: Multimorbidity in a community sample living in marginal housing
American Journal of Psychiatry
DOI: 10.1176/appi.ajp.2013.12111439
2013

Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings
Drug and Alcohol Dependence
DOI: 10.1016/j.drugalcdep.2012.11.016
2013

Excessive antipsychotic dosing in a canadian outpatient population
Psychiatric Services
2011

A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia
Schizophrenia Research
DOI: 10.1016/j.schres.2007.05.002
2007

The need for speed: An update on methamphetamine addiction
Journal of Psychiatry and Neuroscience
2006

ATP released from astrocytes during swelling activates chloride channels
Journal of Neurophysiology
DOI: 10.1152/jn.00510.2002
2003

MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism
American Journal of Physiology - Cell Physiology
2002

P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase
Journal of Neuroscience
2001

Mitogen-activated protein and tyrosine kinases in the activation of astrocyte volume-activated chloride current
Journal of Neuroscience
1998

Research

Current Projects
As a clinical researcher my main goals over the next five years are to continue my work with the homelessness in Vancouver’s downtown eastside, and set up a mild traumatic brain injury research program at the University of British Columbia.

Vancouver’s downtown eastside is home to our most vulnerable population, characterized by a mixture of primary psychiatric illness and refractory addictions. As part of a large team led by Dr. Bill Honer (Head of Psychiatry) we recruit individuals housed in single room occupancy hotels who then undergo detailed medical and psychiatric testing, including brain MRI. This is a longitudinal study that follows approximately 500 individuals for up to 5 years. The data generated is important to policy makers and to science. There are a multitude of opportunities to explore psychiatric and neurological illness from many angels within this study.

My lab is concurrently engaged in the study of traumatic brain injury. We are building a strong team that includes multiple researchers from multiple disciplines here at UBC and abroad. Under the umbrella of the BC Neuropsychiatry program we have recently started the “Neuropsychiatry Concussion Clinic” for those individuals with symptoms that do are not resolving following head trauma. This clinic and others serve as recruitment sites for research studies that focus on the development of biomarkers in concussion, which simply put means finding cognitive, imaging, and blood markers that may predict outcome and response to treatment in those with brain injuries.

Research Group Members

Imad Ahmad, Co-op student
Angela Aquino, Research Coordinator
Julia Askew, Research Volunteer
Devine Calanog
Ryan Chan, Research Assistant
Tasha Chan
Alex Cheng
Mikaela Correa, Research Assistant
Alana Guidry, Research Assistant
Yasmin Hamzah, Research Assistant
Kassia Hayek, Research Assistant
Hiresh Hiresh, Co-op Student
Martina Knappett, Research Assistant
Lexynn Kwan, Coop Student - Medicine
Louise Meddings, Research Assistant
Amiti Mehta, Research Assistant
Victoria Purcell, Research Assistant
Shannon Reid, Coop Student - Medicine
Jacob Scamvougeras, Research Volunteer
Jessica Sevick
Jacob Stubbs, PhD Student, Research trainee
Yomna Takieldeen
Daniel Wolfman, Volunteer
Lisa Zhang
Lauren Zung, Research Assistant