Kevan Jacobson

FRCPC, FACP, MBBCH

Investigator, BC Children's Hospital
Head, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Faculty of Medicine, University of British Columbia
Associate Member, Department of Physiology, University of British Columbia

There is increasing evidence to suggest that intestinal inflammation affects the organization and function of the intestinal nervous system, which controls how our intestine works. As a result, changes in nerve function may alter how the intestine works, worsen inflammation, and aggravate the symptoms in IBD. In our studies we are examining the nerve-intestinal lining responses to inflammation in animal models of IBD and in our children with IBD. We will determine what nerve changes occur in association with intestinal inflammation, how these changes affect the function of the intestinal lining cells and whether these changes persist. We will also examine the potential benefit of probiotics (living non-harmful bacteria).

We are also examining the effects of maternal dietary fat on intestinal lining cells (which protect the host from harmful dietary agents and infectious organisms) and on the intestinal immune response in young offspring.

Academic Affiliations

  • Clinical Professor, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases
  • Research Group(s): Clinical and Community Data, Analytics and Informatics; Immunity in Health and Disease; Mental Health and Behaviour; Origins of Child Health and Disease

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

Biopsy-derived colonoid air-liquid interface monolayers reveal persistent mucosal defects in ulcerative colitis patients

Inflammatory Bowel Diseases

Ashley Gilliland and Yan Chen and Irvin Ng and Xiao Han and Ho Pan Sham and Itay Kalisky and Dominique Lvesque and Kevan Jacobson and Wei Xiong and Franois-Michel Boisvert and Brian Bressler and Bruce A Vallance

DOI: 10.1093/ibd/izaf318

03 / 2026

Pooled prevalence of psychological distress and mental health conditions in older adults with inflammatory bowel disease: a protocol fora systematic review and meta-analysis

Systematic Reviews

Mark Momoh Koroma and Justin Chan and Mielle Michaux and Bwalya Kasanda and Kevan Jacobson

DOI: 10.1186/s13643-026-03106-z

02 / 2026

Development of novel GI-centric prostaglandin E2 receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases

Bioorganic and Medicinal Chemistry Letters

Kantham, S. and Yu, H. and Cantelli, C.R. and Chen, G. and Ma, C. and Chan, J.J. and Yang, H. and Tsai, K. and Lassueur, K. and Vallance, B.A. and Jacobson, K. and Young, R.N.

DOI: 10.1016/j.bmcl.2025.130093

Metabolomics reveal distinct molecular pathways associated with future risk of Crohns Disease

Gut Microbes

Xue, M. and Lee, S.-H. and Shao, J. and Leibovitzh, H. and Huynh, H.Q. and Griffiths, A.M. and Turner, D. and Madsen, K.L. and Moayyedi, P. and Steinhart, A.H. and Silverberg, M.S. and Deslandres, C. and Bitton, A. and Mack, D.R. and Jacobson, K. and Ropeleski, M.J. and Cino, M. and Aumais, G. and Bernstein, C.N. and Panaccione, R. and Bressler, B. and Espin-Garcia, O. and Xu, W. and Turpin, W. and Croitoru, K.

DOI: 10.1080/19490976.2025.2546998

Durability of Antibody Responses to SARS-CoV-2 Vaccination over 12 Months in Pediatric Inflammatory Bowel Disease

Vaccines

Lawrence, S.J. and Vi{\~n}eta Paramo, M. and Reicherz, F. and Bone, J.N. and Shire, Z.J.H. and Bilal, L. and Guerra, G. and Golding, L. and Lavoie, P.M. and Jacobson, K.

DOI: 10.3390/vaccines13060549

Fasting elicits gut microbiome signature changes that extend to type 1 diabetes patients

Frontiers in Endocrinology

Graef, F.A. and Berger, B. and Bahr, L.S. and Stange, R. and Michalsen, A. and Paul, F. and Vallance, B.A. and Jacobson, K.

DOI: 10.3389/fendo.2025.1623800

Early Life Exposure to Parental Crohn's Disease Is Associated With Offspring's Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn's Disease

Gastroenterology

Lee, S.-H. and Bushra, M. and Qiu, L. and Griffiths, A.M. and Turpin, W. and Croitoru, K. and Shao, J. and Olivera, P.A. and Leibovitzh, H. and Xue, M. and Xu, W. and Espin-Garcia, O. and Amuais, G.L. and Huynh, H.Q. and Panaccione, R. and Steinhart, A.H. and Cino, M. and Mack, D. and Marshall, J. and Ropeleski, M. and Bitton, A. and Jacobson, K. and McGrath, J. and Yerushalmi, B. and Abreu, M.T. and Bernstein, C.N. and Radford-Smith, G. and Lees, C. and Turner, D. and Madsen, K. and Guttman, D.S. and Silverberg, M. and Moayyedi, P. and Beck, P. and Dieleman, L. and Feagan, B.G. and Kaplan, G. and Krause, D.O. and Seidman, E. and Snapper, S. and Stadnyk, A. and Surette, M. and Walters, T. and Vallance, B. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Hyams, J. and Otley, A. and Hedin, C. and Hussey, S. and Keljo, D. and Kevans, D. and Murthy, S. and Parekh, N. and Plamondon, S. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C.

DOI: 10.1053/j.gastro.2024.09.033

Neutrophil-To-Lymphocyte Ratio at Diagnosis Predicts Colonoscopic Activity in Pediatric Inflammatory Bowel Diseases

Clinical and Translational Gastroenterology

Aziz, B. and Belaghi, R. and Huynh, H. and Jacobson, K. and Mack, D.R. and Deslandres, C. and Otley, A. and Debruyn, J. and El-Matary, W. and Crowley, E. and Sherlock, M. and Critch, J. and Ahmed, N. and Griffiths, A. and Walters, T. and Wine, E.

DOI: 10.14309/ctg.0000000000000824

Bolstering connectedness through peer support: Randomized-controlled trial of a web-based peer support program for adolescents with inflammatory bowel disease

Health Care Transitions

Ford, M.K. and Iuliano, A. and Walters, T.D. and Otley, A.R. and Mack, D.R. and Jacobson, K. and Rights, J.D. and Tripp, D.A. and Stinson, J.N. and Kohut, S.A.

DOI: 10.1016/j.hctj.2024.100085

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis

Immunity

Hiroki, C.H. and Hassanabad, M.F. and Defaye, M. and Sarden, N. and Bartlett, A. and Farias, R. and Nguyen, A.P. and Guerrero-Fonseca, I.M. and Yoon, G. and Brown, L. and Ma, C. and Yang, H. and Belke, D. and Hassanabad, A.F. and McCoy, C. and Rosin, N.L. and Orton, D.J. and Fedak, P.W.M. and Vallance, B.A. and Yu, H. and Jacobson, K. and Khan, N. and Altier, C. and Kelly, M.M. and Yipp, B.G.

DOI: 10.1016/j.immuni.2025.05.002

Development and Validation of an Integrative Risk Score for Future Risk of Crohn's Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study

Gastroenterology

Lee, S.-H. and Turpin, W. and Espin-Garcia, O. and Xu, W. and Croitoru, K. and Leibovitzh, H. and Xue, M. and Raygoza Garay, J.A. and Gra{\~n}a-Miraglia, L. and Smith, M.I. and Goethel, A. and Madsen, K.L. and Avni-Biron, I. and Dotan, I. and Weiss, B. and Panaccione, R. and Huynh, H. and Jacobson, K. and Aumais, G. and Mack, D. and Griffiths, A.M. and Steinhart, A.H. and Silverberg, M.S. and Turner, D. and Bernstein, C.N. and Feagan, B.G. and Moayyedi, P. and Paterson, A. and Guttman, D.S. and Abreu, M. and Beck, P. and Dieleman, L. and Kaplan, G. and Krause, D.O. and Marshall, J. and Ropeleski, M. and Seidman, E. and Snapper, S. and Stadnyk, A. and Surette, M. and Walters, T. and Vallance, B. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Hyams, J. and McGrath, J. and Otley, A.

DOI: 10.1053/j.gastro.2024.08.021

Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model

Frontiers in Immunology

Sharafian, Z. and Littlejohn, P.T. and Michalski, C. and Sousa, J.A. and Cheung, J. and Hill, M. and Piper, H. and Jacobson, K. and Lavoie, P.M. and Allaire, J.M. and Vallance, B.A.

DOI: 10.3389/fimmu.2025.1582688

Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn's Disease

Gastroenterology

Olivera, P.A. and Martinez-Lozano, H. and Leibovitzh, H. and Xue, M. and Neustaeter, A. and Espin-Garcia, O. and Xu, W. and Madsen, K.L. and Guttman, D.S. and Bernstein, C.N. and Yerushalmi, B. and Hyams, J.S. and Abreu, M.T. and Marshall, J.K. and Wrobel, I. and Mack, D.R. and Jacobson, K. and Bitton, A. and Aumais, G. and Panacionne, R. and Dieleman, L.A. and Silverberg, M.S. and Steinhart, A.H. and Moayyedi, P. and Turner, D. and Griffiths, A.M. and Turpin, W. and Lee, S.-H. and Croitoru, K. and Beck, P. and Feagan, B. and Griffiths, A. and Kaplan, G. and Krause, D.O. and Ropeleski, M. and Seidman, E. and Snapper, S. and Stadnyk, A. and Surette, M. and Walters, T. and Vallance, B. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H.Q. and McGrath, J. and Otley, A. and Panaccione, R.

DOI: 10.1053/j.gastro.2024.08.031

The role of upper gastrointestinal endoscopy in the diagnosis of pediatric inflammatory bowel disease

American Journal of Clinical Pathology

Becky Biqi Chen and Zachary Hamilton and Mohammed Hasosah and Peter Zetler and Oana Popescu and Jonathan Bush and Rael Katz and Matthew Smyth and Kevan Jacobson

DOI: 10.1093/ajcp/aqae074

12 / 2024

Adalimumab vs Infliximab in Luminal Pediatric Crohns Disease: Comparable Outcomes in a Prospective Multicenter Cohort Study

American Journal of Gastroenterology

deBruyn, J.C. and Huynh, H.Q. and Griffiths, A.M. and Jacobson, K. and Mack, D. and Deslandres, C. and El-Matary, W. and Otley, A.R. and Church, P.C. and Lawrence, S. and Wine, E. and Sherlock, M. and Critch, J. and Benchimol, E.I. and Jantchou, P. and Rashid, M. and Carroll, M.W. and Bax, K. and Ricciuto, A. and Carman, N. and Walters, T.D.

DOI: 10.14309/ajg.0000000000002552

Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients

Inflammatory Bowel Diseases

Kennedy, A.M. and Griffiths, A.M. and Muise, A.M. and Walters, T.D. and Ricciuto, A. and Huynh, H.Q. and Wine, E. and Jacobson, K. and Lawrence, S. and Carman, N. and Mack, D.R. and deBruyn, J.C. and Otley, A.R. and Deslandres, C. and El-Matary, W. and Zachos, M. and Benchimol, E.I. and Critch, J. and Schneider, R. and Crowley, E. and Li, M. and Warner, N. and McGovern, D.P.B. and Li, D. and Haritunians, T. and Rudin, S. and Cohn, I.

DOI: 10.1093/ibd/izae109

Environmental Factors Associated With Risk of Crohn's Disease Development in the Crohn's and Colitis Canada - Genetic, Environmental, Microbial Project

Clinical Gastroenterology and Hepatology

Xue, M. and Leibovitzh, H. and Jingcheng, S. and Neustaeter, A. and Dong, M. and Xu, W. and Espin-Garcia, O. and Griffiths, A.M. and Steinhart, A.H. and Turner, D. and Huynh, H.Q. and Dieleman, L.A. and Panaccione, R. and Aumais, G. and Bressler, B. and Bitton, A. and Murthy, S. and Marshall, J.K. and Hyams, J.S. and Otley, A. and Bernstein, C.N. and Moayyedi, P. and El-Matary, W. and Fich, A. and Denson, L.A. and Ropeleski, M.J. and Abreu, M.T. and Deslandres, C. and Cino, M. and Avni-Biron, I. and Lee, S.-H. and Turpin, W. and Abreu, M. and Beck, P. and Bernstein, C. and Croitoru, K. and Feagan, B. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Walters, T. and Vallance, B. and Critch, J. and Denson, L. and Herfarth, H. and Higgins, P. and Huynh, H. and Mack, D. and McGrath, J. and Panancionne, R.

DOI: 10.1016/j.cgh.2024.03.049

Response from the Canadian Children Inflammatory Bowel Disease Network to the US Food and Drug Administration Draft Guidance for Industry on pediatric inflammatory bowel disease: developing drugs for treatment

Journal of the Canadian Association of Gastroenterology

Wine, E. and Debruyn, J. and Crowley, E. and Griffiths, A.M. and Jeong, J. and Jacobson, K. and Lawrence, S. and Piper, H. and Smyth, M. and Tropini, C. and Vallance, B. and de Bruyn, J. and Huynh, H. and Carroll, M. and Isaac, D.M. and Armstrong, H. and El-Matary, W. and Grover, Z. and Bax, K. and Brill, H. and Dowhaniuk, J. and Prowse, K. and Sherlock, M. and Zachos, M. and Hart, L. and Popalis, C. and Griffths, A.M. and Muise, A. and Ricciuto, A. and Benchimol, E. and Jones, N. and Carman, N. and Church, P. and Walters, T. and Mulder, D. and Mack, D. and Stanisz, J. and Stintzi, A. and Pai, N. and Deslandres, C. and Breton, J. and Grzywacz, K. and Jantchou, P. and Chapuy, L. and Schneider, R. and Otley, A. and Burnett, D. and Critch, J. and Dinn, S.

DOI: 10.1093/jcag/gwae034

Outcomes Following Acute Severe Colitis at Initial Presentation: A Multi-centre, Prospective, Paediatric Cohort Study

Journal of Crohn's and Colitis

Dhaliwal, J. and Tertigas, D. and Carman, N. and Lawrence, S. and Debruyn, J.C. and Wine, E. and Church, P.C. and Huynh, H.Q. and Rashid, M. and El-Matary, W. and Deslandres, C. and Critch, J. and Ricciuto, A. and Carroll, M.W. and Benchimol, E.I. and Muise, A. and Jacobson, K. and Otley, A.R. and Vallance, B. and Mack, D.R. and Walters, T.D. and Surette, M.G. and Griffiths, A.M.

DOI: 10.1093/ecco-jcc/jjad143

Health Services Utilization and Specialist Care in Pediatric Inflammatory Bowel Disease: A Multiprovince Population-Based Cohort Study

Inflammatory Bowel Diseases

Kuenzig, M.E. and Bitton, A. and Carroll, M.W. and Otley, A.R. and Singh, H. and Kaplan, G.G. and Stukel, T.A. and Mack, D.R. and Jacobson, K. and Griffiths, A.M. and El-Matary, W. and Targownik, L.E. and Nguyen, G.C. and Jones, J.L. and Murthy, S.K. and Bernstein, C.N. and Lix, L.M. and Pe{\~n}a-S{\'a}nchez, J.N. and Dummer, T.J.B. and Spruin, S. and Fung, S.G. and Nugent, Z. and Coward, S. and Cui, Y. and Coulombe, J. and Filliter, C. and Benchimol, E.I.

DOI: 10.1093/ibd/izae010

Variation in the Care of Children with Inflammatory Bowel Disease Within and Across Canadian Provinces: A Multi-Province Population-Based Cohort Study

Clinical Epidemiology

Kuenzig, M.E. and Stukel, T.A. and Carroll, M.W. and Kaplan, G.G. and Otley, A.R. and Singh, H. and Bitton, A. and Fung, S.G. and Spruin, S. and Coward, S. and Cui, Y. and Nugent, Z. and Griffiths, A.M. and Mack, D.R. and Jacobson, K. and Nguyen, G.C. and Targownik, L.E. and El-Matary, W. and Bernstein, C.N. and Dummer, T.J.B. and Jones, J.L. and Lix, L.M. and Murthy, S.K. and Pea-Snchez, J.N. and Nasiri, S. and Benchimol, E.I.

DOI: 10.2147/CLEP.S449183

Insights Into Inflammatory Bowel Disease and Effects of Dietary Fatty Acid Intake With a Focus on Polyunsaturated Fatty Acids Using Preclinical Models

Journal of the Canadian Association of Gastroenterology

Smyth, M. and Lunken, G. and Jacobson, K.

DOI: 10.1093/jcag/gwad058

Pre-Diagnosis Diet Predicts Response to Exclusive Enteral Nutrition and Correlates with Microbiome in Pediatric Crohn Disease

Nutrients

Dijk, S. and Jarman, M. and Zhang, Z. and Lawley, M. and Ahmad, M. and Suarez, R. and Rossi, L. and Chen, M. and Wu, J. and Carroll, M.W. and Otley, A. and Sherlock, M. and Mack, D.R. and Jacobson, K. and deBruyn, J.C. and El-Matary, W. and Deslandres, C. and Rashid, M. and Church, P.C. and Walters, T.D. and Huynh, H.Q. and Surette, M.G. and Griffiths, A.M. and Wine, E.

DOI: 10.3390/nu16071033

Forecasting the Incidence and Prevalence of Inflammatory Bowel Disease: A Canadian Nationwide Analysis

American Journal of Gastroenterology

Coward, S. and Benchimol, E.I. and Bernstein, C.N. and Avina-Zubieta, A. and Bitton, A. and Carroll, M.W. and Cui, Y. and Hoentjen, F. and Hracs, L. and Jacobson, K. and Jones, J.L. and King, J. and Kuenzig, M.E. and Lu, N. and El-Matary, W. and Murthy, S.K. and Nugent, Z. and Otley, A.R. and Panaccione, R. and Pea-Snchez, J.N. and Singh, H. and Targownik, L.E. and White, D. and Windsor, J.W. and Kaplan, G.G.

DOI: 10.14309/ajg.0000000000002687

Understanding Predictors of Crohn's Disease: Determinants of Altered Barrier Function in Pre-Disease Phase of Crohn's Disease

Journal of the Canadian Association of Gastroenterology

Neustaeter, A. and Leibovitzh, H. and Turpin, W. and Croitoru, K. and Abreu, M. and Beck, P. and Bernstein, C. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Moayyedi, P. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R. and Abreu, M. and Baldassano, R. and Griffiths, A.M. and Hedin, C. and Higgins, P. and Hussey, S. and Hyams, H. and Keljo, D. and Kevans, D. and Lees, C. and Marshall, J. and Murthy, S. and Panaccione, R. and Parekh, N. and Plamondon, S. and Radford-Smith, G. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C.

DOI: 10.1093/jcag/gwad052

Highly Sensitive, Flow Cytometry-Based Measurement of Intestinal Permeability in Models of Experimental Colitis

Cellular and Molecular Gastroenterology and Hepatology

Tsai, K. and Ma, C. and Han, X. and Allaire, J. and Healey, G.R. and Crowley, S.M. and Yu, H. and Jacobson, K. and Xia, L. and Priatel, J.J. and Vallance, B.A.

DOI: 10.1016/j.jcmgh.2022.10.004

Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives

Gastroenterology

Raygoza Garay, J.A. and Turpin, W. and Lee, S.-H. and Smith, M.I. and Goethel, A. and Griffiths, A.M. and Moayyedi, P. and Espin-Garcia, O. and Abreu, M. and Aumais, G.L. and Bernstein, C.N. and Biron, I.A. and Cino, M. and Deslandres, C. and Dotan, I. and El-Matary, W. and Feagan, B. and Guttman, D.S. and Huynh, H. and Dieleman, L.A. and Hyams, J.S. and Jacobson, K. and Mack, D. and Marshall, J.K. and Otley, A. and Panaccione, R. and Ropeleski, M. and Silverberg, M.S. and Steinhart, A.H. and Turner, D. and Yerushalmi, B. and Paterson, A.D. and Xu, W. and Beck, P. and Bernstein, C. and Croitoru, K. and Griffiths, A. and Guttman, D. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Critch, J. and Denson, L. and Herfarth, H. and Higgins, P. and McGrath, J. and Panancionne, R.

DOI: 10.1053/j.gastro.2023.05.032

Inflammatory Bowel Disease Among Canadian Children: Comparison Between Children of Non-European Descent and Children of European Descent

Inflammatory Bowel Diseases

Jeong, J. and Walters, T.D. and Huynh, H.Q. and Lawrence, S. and Mack, D.R. and Deslandres, C. and Otley, A. and El-Matary, W. and Sherlock, M. and Griffiths, A.M. and Wine, E. and Jacobson, K. and Church, P. and Carroll, M.W. and Benchimol, E.I. and Brill, H. and Critch, J. and Bax, K. and Jantchou, P. and Rashid, M. and Kaplan, G.G. and Seow, C.H. and Novak, K. and deBruyn, J.C.

DOI: 10.1093/ibd/izac276

User testing to modify the MyHealthyGut digital health application for inflammatory bowel disease

Digital Health

Erlich, M. and Lindblad, S. and Haskey, N. and Clarkin, D.H. and Dong, T. and Harvie, R. and Lunken, G. and Pirnack, J. and Jacobson, K.

DOI: 10.1177/20552076231203664

Spatial cluster mapping and environmental modeling in pediatric inflammatory bowel disease

World Journal of Gastroenterology

Michaux, M. and Chan, J.M. and Bergmann, L. and Chaves, L.F. and Klinkenberg, B. and Jacobson, K.

DOI: 10.3748/wjg.v29.i23.3688

Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn's disease highlight earliest events of pathogenesis

Gut

Leibovitzh, H. and Lee, S.-H. and Raygoza Garay, J.A. and Espin-Garcia, O. and Xue, M. and Neustaeter, A. and Goethel, A. and Huynh, H.Q. and Griffiths, A.M. and Turner, D. and Madsen, K.L. and Moayyedi, P. and Steinhart, A.H. and Silverberg, M.S. and Deslandres, C. and Bitton, A. and Mack, D.R. and Jacobson, K. and Cino, M. and Aumais, G. and Bernstein, C.N. and Panaccione, R. and Weiss, B. and Halfvarson, J. and Xu, W. and Turpin, W. and Croitoru, K.

DOI: 10.1136/gutjnl-2022-328421

User testing to inform modification of the MyHealthyGut digital health application in inflammatory bowel disease

medRxiv

Erlich, M. and Lindblad, S. and Haskey, N. and Clarkin, D.H. and Dong, T. and Harvie, R. and Lunken, G. and Pirnack, J. and Jacobson, K.

DOI: 10.1101/2023.03.23.23287648

Transition Readiness in Youth with Inflammatory Bowel Disease

Journal of Pediatrics

Foster, A. and Chan, J.M. and Wine, E. and El-Matary, W. and Carroll, M.W. and Kroeker, K.I. and deBruyn, J.C. and Seow, C.H. and Lawrence, S. and Evans, K. and Kluthe, C. and Sharifi, N. and Pears, C. and Nicol, S. and Olayinka, L. and Fu, N. and Huynh, H.Q. and Bressler, B. and Bernstein, C.N. and Jacobson, K.

DOI: 10.1016/j.jpeds.2023.113403

Anti-Integrin av6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis

Gastroenterology

Livanos, A.E. and Dunn, A. and Fischer, J. and Ungaro, R.C. and Turpin, W. and Lee, S.-H. and Rui, S. and Del Valle, D.M. and Jougon, J.J. and Martinez-Delgado, G. and Riddle, M.S. and Murray, J.A. and Laird, R.M. and Torres, J. and Agrawal, M. and Magee, J.S. and Dervieux, T. and Gnjatic, S. and Sheppard, D. and Sands, B.E. and Porter, C.K. and Croitoru, K. and Petralia, F. and Abreu, M. and Beck, P. and Bernstein, C. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Moayyedi, P. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R. and Shapiro, J. and Shah, S. and Leleiko, N.S. and Colombel, J.-F. and Mehandru, S.

DOI: 10.1053/j.gastro.2022.12.042

A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial

Journal of Crohn's and Colitis

Haskey, N. and Estaki, M. and Ye, J. and Shim, R.K. and Singh, S. and Dieleman, L.A. and Jacobson, K. and Gibson, D.L.

DOI: 10.1093/ecco-jcc/jjad073

Antibody response to the BNT162b2 SARS-CoV-2 vaccine in paediatric patients with inflammatory bowel disease treated with anti-TNF therapy

Gut

Zahra Jama Shire and Frederic Reicherz and Sally Lawrence and Harjeev Sudan and Liam Golding and Abdelilah Majdoubi and Paul N Levett and Pascal M Lavoie and Kevan Jacobson

DOI: 10.1136/gutjnl-2021-326196

09 / 2022

Canadian Consensus Statements on the Transition of Adolescents and Young Adults with Inflammatory Bowel Disease from Pediatric to Adult Care: A Collaborative Initiative Between the Canadian IBD Transition Network and Crohn's and Colitis Canada

Journal of the Canadian Association of Gastroenterology

Fu, N. and Bollegala, N. and Jacobson, K. and Kroeker, K.I. and Frost, K. and Afif, W. and El-Matary, W. and Fowler, S.A. and Griffiths, A.M. and Huynh, H.Q. and Jantchou, P. and Karimuddin, A. and Nguyen, G.C. and Otley, A.R. and Pears, C. and Seow, C.H. and Toulany, A. and Tersigni, C. and Tignanelli, J. and Marshall, J.K. and Boctor, M. and Hansen, T. and Pattni, C. and Wong, A. and Benchimol, E.I.

DOI: 10.1093/jcag/gwab050

Dietary adherence to the Mediterranean diet pattern in a randomized clinical trial of patients with quiescent ulcerative colitis

Frontiers in Nutrition

Haskey, N. and Shim, R.C.K. and Davidson-Hunt, A. and Ye, J. and Singh, S. and Dieleman, L.A. and Jacobson, K. and Ghosh, S. and Gibson, D.L.

DOI: 10.3389/fnut.2022.1080156

Pediatric Endoscopy Quality Improvement Network Quality Standards and Indicators for Pediatric Endoscopists and Endoscopists in Training: A Joint NASPGHAN/ESPGHAN Guideline

Journal of Pediatric Gastroenterology and Nutrition

Walsh, C.M. and Lightdale, J.R. and Leibowitz, I.H. and Lerner, D.G. and Liu, Q.Y. and Mack, D.R. and Mamula, P. and Narula, P. and Oliva, S. and Riley, M.R. and Rosh, J.R. and Tavares, M. and Utterson, E.C. and Amil-Dias, J. and Bontems, P. and Brill, H. and Croft, N.M. and Fishman, D.S. and Furlano, R.I. and Gillett, P.M. and Hojsak, I. and Homan, M. and Huynh, H.Q. and Jacobson, K. and Ambartsumyan, L. and Otley, A.R. and Kramer, R.E. and McCreath, G.A. and Connan, V. and Thomson, M.A.

DOI: 10.1097/MPG.0000000000003265

Pediatric Endoscopy Quality Improvement Network Quality Standards and Indicators for Pediatric Endoscopy Facilities: A Joint NASPGHAN/ESPGHAN Guideline

Journal of Pediatric Gastroenterology and Nutrition

Lightdale, J.R. and Walsh, C.M. and Narula, P. and Utterson, E.C. and Tavares, M. and Rosh, J.R. and Riley, M.R. and Oliva, S. and Mamula, P. and Mack, D.R. and Liu, Q.Y. and Lerner, D.G. and Leibowitz, I.H. and Jacobson, K. and Huynh, H.Q. and Homan, M. and Hojsak, I. and Gillett, P.M. and Furlano, R.I. and Fishman, D.S. and Croft, N.M. and Brill, H. and Bontems, P. and Amil-Dias, J. and Kramer, R.E. and Ambartsumyan, L. and Otley, A.R. and McCreath, G.A. and Connan, V. and Thomson, M.A.

DOI: 10.1097/MPG.0000000000003263

Pediatric Endoscopy Quality Improvement Network Quality Standards and Indicators for Pediatric Endoscopic Procedures: A Joint NASPGHAN/ESPGHAN Guideline

Journal of Pediatric Gastroenterology and Nutrition

Lightdale, J.R. and Walsh, C.M. and Oliva, S. and Jacobson, K. and Huynh, H.Q. and Homan, M. and Hojsak, I. and Gillett, P.M. and Furlano, R.I. and Fishman, D.S. and Croft, N.M. and Brill, H. and Bontems, P. and Amil-Dias, J. and Utterson, E.C. and Tavares, M. and Rosh, J.R. and Riley, M.R. and Narula, P. and Mamula, P. and Mack, D.R. and Liu, Q.Y. and Lerner, D.G. and Leibowitz, I.H. and Otley, A.R. and Kramer, R.E. and Ambartsumyan, L. and Connan, V. and McCreath, G.A. and Thomson, M.A.

DOI: 10.1097/MPG.0000000000003264

Pediatric Endoscopy Quality Improvement Network Pediatric Endoscopy Reporting Elements: A Joint NASPGHAN/ESPGHAN Guideline

Journal of Pediatric Gastroenterology and Nutrition

Walsh, C.M. and Lightdale, J.R. and Fishman, D.S. and Furlano, R.I. and Mamula, P. and Gillett, P.M. and Narula, P. and Hojsak, I. and Oliva, S. and Homan, M. and Riley, M.R. and Huynh, H.Q. and Rosh, J.R. and Jacobson, K. and Tavares, M. and Leibowitz, I.H. and Utterson, E.C. and Croft, N.M. and Mack, D.R. and Brill, H. and Liu, Q.Y. and Bontems, P. and Lerner, D.G. and Amil-Dias, J. and Kramer, R.E. and Otley, A.R. and Ambartsumyan, L. and Connan, V. and McCreath, G.A. and Thomson, M.A.

DOI: 10.1097/MPG.0000000000003266

Overview of the Pediatric Endoscopy Quality Improvement Network Quality Standards and Indicators for Pediatric Endoscopy: A Joint NASPGHAN/ESPGHAN Guideline

Journal of Pediatric Gastroenterology and Nutrition

Walsh, C.M. and Lightdale, J.R. and Mack, D.R. and Amil-Dias, J. and Bontems, P. and Brill, H. and Croft, N.M. and Fishman, D.S. and Furlano, R.I. and Gillett, P.M. and Hojsak, I. and Homan, M. and Huynh, H.Q. and Jacobson, K. and Leibowitz, I.H. and Lerner, D.G. and Liu, Q.Y. and Mamula, P. and Narula, P. and Oliva, S. and Riley, M.R. and Rosh, J.R. and Tavares, M. and Utterson, E.C. and Ambartsumyan, L. and Otley, A.R. and Kramer, R.E. and Connan, V. and McCreath, G.A. and Thomson, M.A.

DOI: 10.1097/MPG.0000000000003262

Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn's Disease

Gastroenterology

Leibovitzh, H. and Lee, S.-H. and Xue, M. and Raygoza Garay, J.A. and Hernandez-Rocha, C. and Madsen, K.L. and Meddings, J.B. and Guttman, D.S. and Espin-Garcia, O. and Smith, M.I. and Goethel, A. and Griffiths, A.M. and Moayyedi, P. and Steinhart, A.H. and Panaccione, R. and Huynh, H.Q. and Jacobson, K. and Aumais, G. and Mack, D.R. and Abreu, M.T. and Bernstein, C.N. and Marshall, J.K. and Turner, D. and Xu, W. and Turpin, W. and Croitoru, K.

DOI: 10.1053/j.gastro.2022.07.004

The Phenotypic Spectrum of New-onset IBD in Canadian Children of South Asian Ethnicity: A Prospective Multi-Centre Comparative Study

Journal of Crohn's and Colitis

Dhaliwal, J. and Carroll, M.W. and Debruyn, J.C. and Ricciuto, A. and Benchimol, E.I. and Lawrence, S. and Sherlock, M. and El-Matary, W. and Brill, H. and Church, P. and Wine, E. and Carman, N. and Muise, A. and Huynh, H. and Mack, D.R. and Walters, T.D. and Griffiths, A.M. and Jacobson, K.

DOI: 10.1093/ecco-jcc/jjab143

Indirect and Out-of-Pocket Disease-associated Costs in Pediatric Inflammatory Bowel Disease: A Cross-sectional Analysis

Journal of Pediatric Gastroenterology and Nutrition

El-Matary, W. and Witt, J. and Bernstein, C.N. and Jacobson, K. and Mack, D. and Otley, A. and Walters, T.D. and Huynh, H.Q. and Debruyn, J. and Griffiths, A.M. and Benchimol, E.I.

DOI: 10.1097/MPG.0000000000003545

Hospitalization with Clostridioides difficile in Pediatric Inflammatory Bowel Disease: A Population-Based Study

Journal of Pediatric Gastroenterology and Nutrition

Kuenzig, M.E. and Benchimol, E.I. and Bernstein, C.N. and Bitton, A. and Carroll, M.W. and Griffiths, A.M. and Kaplan, G.G. and Nguyen, G.C. and Otley, A.R. and Stukel, T.A. and Dummer, T.J.B. and El-Matary, W. and Jacobson, K. and Jones, J.L. and Lix, L.M. and Mack, D.R. and Murthy, S.K. and Pe{\~n}a-S{\'a}nchez, J.-N. and Targownik, L.E. and Fung, S.G. and Spruin, S. and Coward, S. and Cui, Y. and Filliter, C. and Nugent, Z. and Siddiq, S. and Singh, H.

DOI: 10.1097/MPG.0000000000003489

Progression to Anti-TNF Treatment in Very Early Onset Inflammatory Bowel Disease Patients

Journal of Pediatric Gastroenterology and Nutrition

Eindor-Abarbanel, A. and Meleady, L. and Lawrence, S. and Hamilton, Z. and Krikler, G. and Lakhani, A. and Zhang, Q. and Jacobson, K.

DOI: 10.1097/MPG.0000000000003551

Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation

Gastroenterology

Turpin, W. and Dong, M. and Sasson, G. and Raygoza Garay, J.A. and Espin-Garcia, O. and Lee, S.-H. and Neustaeter, A. and Smith, M.I. and Leibovitzh, H. and Guttman, D.S. and Goethel, A. and Griffiths, A.M. and Huynh, H.Q. and Dieleman, L.A. and Panaccione, R. and Steinhart, A.H. and Silverberg, M.S. and Aumais, G. and Jacobson, K. and Mack, D. and Murthy, S.K. and Marshall, J.K. and Bernstein, C.N. and Abreu, M.T. and Moayyedi, P. and Paterson, A.D. and Abreu, M. and Beck, P. and Bernstein, C. and Croitoru, K. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and McGrath, J. and Otley, A. and Panancionne, R. and Baldassano, R. and Hedin, C. and Hussey, S. and Hyams, H. and Keljo, D. and Kevans, D. and Lees, C. and Murthy, S. and Parekh, N. and Plamondon, S. and Radford-Smith, G. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C. and Xu, W.

DOI: 10.1053/j.gastro.2022.05.037

Knowledge and practice of pediatricians regarding childhood constipation in the Arab world: results from a multicenter survey

BMC Pediatrics

Hasosah, M. and Haleem, A. and Jacobson, K. and Alshemmeri, B. and Alenazi, A. and Badei, A.A. and Massoud, P.

DOI: 10.1186/s12887-022-03536-3

Optimized Infliximab Induction Predicts Better Long-Term Clinical and Biomarker Outcomes Compared to Standard Induction Dosing

Journal of Pediatric Gastroenterology and Nutrition

Lawrence, S. and Faytrouni, F. and Harris, R.E. and Irvine, M. and Carrion, E. and Scott, G. and Clarke, B. and Garrick, V. and Curtis, L. and Gervais, L. and Tayler, R. and Riou, M. and Hansen, R. and Jacobson, K. and Russell, R.K.

DOI: 10.1097/MPG.0000000000003587

Pediatric Quality of Life InventoryTM version 4.0 short form generic core scale across pediatric populations review data

Data in Brief

Matthew Smyth and Kevan Jacobson

DOI: 10.1016/j.dib.2021.107599

12 / 2021

Therapeutic Advances in Gut Microbiome Modulation in Patients with Inflammatory Bowel Disease from Pediatrics to Adulthood

International Journal of Molecular Sciences

Adi Eindor-Abarbanel and Genelle R. Healey and Kevan Jacobson

DOI: 10.3390/ijms222212506

11 / 2021

AN INULIN-TYPE FRUCTAN ENRICHED EXCLUSIVE ENTERAL NUTRITION FORMULA SUPPRESSES COLITIS THROUGH GUT MICROBIOME MODULATION AND PROMOTING EXPANSION OF ANTI-INFLAMMATORY T CELL SUBSETS

Genelle R. Healey and Kevin Tsai and Daniel J. Lisko and Laura Cook and Bruce A. Vallance and Kevan Jacobson

DOI: 10.1101/2021.02.02.429403

02 / 2021

Comparing Health Administrative and Clinical Registry Data: Trends in Incidence and Prevalence of Pediatric Inflammatory Bowel Disease in British Columbia

Clinical Epidemiology

Justin M Chan and Matthew W Carroll and Matthew Smyth and Zachary Hamilton and Dewey Evans and Kimberlyn McGrail and Eric I Benchimol and Kevan Jacobson

DOI: 10.2147/CLEP.S292546

02 / 2021

Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis

Gastroenterology

Galipeau, H.J. and Caminero, A. and Turpin, W. and Bermudez-Brito, M. and Santiago, A. and Libertucci, J. and Constante, M. and Raygoza Garay, J.A. and Rueda, G. and Armstrong, S. and Clarizio, A. and Smith, M.I. and Surette, M.G. and Bercik, P. and Beck, P. and Bernstein, C. and Croitoru, K. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Moayyedi, P. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R. and Verdu, E.F.

DOI: 10.1053/j.gastro.2020.12.004

Vasoactive intestinal peptide promotes host defense against enteric pathogens by modulating the recruitment of group 3 innate lymphoid cells

Proceedings of the National Academy of Sciences of the United States of America

Yu, H.B. and Yang, H. and Allaire, J.M. and Ma, C. and Graef, F.A. and Mortha, A. and Liang, Q. and Bosman, E.S. and Reid, G.S. and Waschek, J.A. and Osborne, L.C. and Sokol, H. and Vallance, B.A. and Jacobson, K.

DOI: 10.1073/pnas.2106634118

Inflammatory Bowel Disease Increases the Risk of Venous Thromboembolism in Children: A Population-Based Matched Cohort Study

Journal of Crohn's & colitis

Kuenzig, M.E. and Bitton, A. and Carroll, M.W. and Kaplan, G.G. and Otley, A.R. and Singh, H. and Nguyen, G.C. and Griffiths, A.M. and Stukel, T.A. and Targownik, L.E. and Jones, J.L. and Murthy, S.K. and McCurdy, J.D. and Bernstein, C.N. and Lix, L.M. and Pea-Snchez, J.N. and Mack, D.R. and Jacobson, K. and El-Matary, W. and Dummer, T.J.B. and Fung, S.G. and Spruin, S. and Nugent, Z. and Tanyingoh, D. and Cui, Y. and Filliter, C. and Coward, S. and Siddiq, S. and Benchimol, E.I.

DOI: 10.1093/ecco-jcc/jjab113

Prebiotic Enriched Exclusive Enteral Nutrition Suppresses Colitis via Gut Microbiome Modulation and Expansion of Anti-inflammatory T Cells in a Mouse Model of Colitis

Cellular and Molecular Gastroenterology and Hepatology

Genelle R. Lunken and Kevin Tsai and Alana Schick and Daniel J. Lisko and Laura Cook and Bruce A. Vallance and Kevan Jacobson

DOI: 10.1016/j.jcmgh.2021.06.011

Harnessing Big Data to Optimize an Algorithm for Rapid Diagnosis of Pulmonary Tuberculosis in a Real-World Setting

Frontiers in Cellular and Infection Microbiology

Peng, J. and Song, J. and Wang, F. and Zuo, P. and Lu, Y. and Liu, W. and Tian, L. and Chen, Z. and Zhu, Y. and Wang, X. and Shen, N. and Wang, X. and Wu, S. and Yu, Q. and Vallance, B.A. and Jacobson, K. and Sun, Z. and Yu, H.B.

DOI: 10.3389/fcimb.2021.650163

Early Serum Infliximab Levels in Pediatric Ulcerative Colitis

Frontiers in Pediatrics

deBruyn, J.C.C. and Jacobson, K. and El-Matary, W. and Wine, E. and Carroll, M.W. and Goedhart, C. and Panaccione, R. and Wrobel, I.T. and Huynh, H.Q.

DOI: 10.3389/fped.2021.668978

Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection

PLoS Pathogens

Graef, F.A. and Celiberto, L.S. and Allaire, J.M. and Kuan, M.T.Y. and Bosman, E.S. and Crowley, S.M. and Yang, H. and Chan, J.H. and Stahl, M. and Yu, H. and Quin, C. and Gibson, D.L. and Verdu, E.F. and Jacobson, K. and Vallance, B.A.

DOI: 10.1371/journal.ppat.1009719

E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis

Nature Cell Biology

Patankar, J.V. and Mller, T.M. and Kantham, S. and Acera, M.G. and Mascia, F. and Scheibe, K. and Mahapatro, M. and Heichler, C. and Yu, Y. and Li, W. and Ruder, B. and Gnther, C. and Leppkes, M. and Mathew, M.J. and Wirtz, S. and Neufert, C. and Khl, A.A. and Paquette, J. and Jacobson, K. and Atreya, R. and Zundler, S. and Neurath, M.F. and Young, R.N. and Becker, C.

DOI: 10.1038/s41556-021-00708-8

Cross-Sectional Analysis of Quality of Life in Pediatric Patients with Inflammatory Bowel Disease in British Columbia, Canada

Journal of Pediatrics

Smyth, M. and Chan, J. and Evans, K. and Penner, C. and Lakhani, A. and Newlove, T. and Jacobson, K.

DOI: 10.1016/j.jpeds.2021.07.036

Anti-Microbial Antibody Response is Associated With Future Onset of Crohn's Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk

Gastroenterology

Lee, S.-H. and Turpin, W. and Espin-Garcia, O. and Raygoza Garay, J.A. and Smith, M.I. and Leibovitzh, H. and Goethel, A. and Turner, D. and Mack, D. and Deslandres, C. and Cino, M. and Aumais, G. and Panaccione, R. and Jacobson, K. and Bitton, A. and Steinhart, A.H. and Huynh, H.Q. and Princen, F. and Moayyedi, P. and Griffiths, A.M. and Silverberg, M.S. and Paterson, A.D. and Xu, W. and Croitoru, K.

DOI: 10.1053/j.gastro.2021.07.009

Serum Zonulin Measured by Commercial Kit Fails to Correlate With Physiologic Measures of Altered Gut Permeability in First Degree Relatives of Crohn's Disease Patients

Frontiers in Physiology

Power, N. and Turpin, W. and Espin-Garcia, O. and Smith, M.I. and Croitoru, K. and Abreu, M. and Beck, P. and Bernstein, C. and Dieleman, L. and Feagan, B. and Griffiths, A. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Moayyedi, P. and Ropeleski, M. and Seidman, E. and Silverberg, M. and Snapper, S. and Stadnyk, A. and Steinhart, H. and Surette, M. and Turner, D. and Walters, T. and Vallance, B. and Aumais, G. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Huynh, H. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R.

DOI: 10.3389/fphys.2021.645303

Interleukin-37 Regulates Innate Immune Signaling in Human and Mouse Colonic Organoids

Allaire J and Poon A and Crowley S and Han X and Moore N and Stahl M and Bressler B and Jacobson K and Li X and Vallance B

DOI: 10.21203/rs.3.rs-126899/v1

12 / 2020

Severe COVID-19 Infection and Pediatric Comorbidities: A Systematic Review and Meta-Analysis

International Journal of Infectious Diseases

Boyan K. Tsankov and Joannie M. Allaire and Michael A. Irvine and Alison A. Lopez and Laura J. Sauv and Bruce A. Vallance and Kevan Jacobson

DOI: 10.1016/j.ijid.2020.11.163

11 / 2020

Diagnostic Delay Is Associated with Complicated Disease and Growth Impairment in Paediatric Crohn's Disease.

Journal of Crohn's & colitis

Ricciuto A and Mack DR and Huynh HQ and Jacobson K and Otley AR and deBruyn J and El-Matary W and Deslandres C and Sherlock ME and Critch JN and Bax K and Jantchou P and Seidman EG and Church PC

DOI: 10.1093/ecco-jcc/jjaa197 PubMed: 32978629

09 / 2020

Increased Intestinal Permeability is Associated with Later Development of Crohn's Disease.

Gastroenterology

Turpin W and Lee SH and Raygoza Garay JA and Madsen KL and Meddings JB and Bedrani L and Power N and Espin-Garcia O and Xu W and Smith MI and Griffiths AM and Moayyedi P and Turner D and CCC GEM Project Research Consortium

DOI: 10.1053/j.gastro.2020.08.005 PubMed: 32791132

08 / 2020

Discontinuation of Immunosuppressive Medications in Children with Inflammatory Bowel Disease on Combination Therapy.

Journal of pediatric gastroenterology and nutrition

El-Matary W and Carroll MW and deBruyn JC and Huynh H and Wine E and Lawrence S and Chandrakumar A and Morel T and Jacobson K

DOI: 10.1097/mpg.0000000000002857 PubMed: 32740529

07 / 2020

Enteroids Derived From Inflammatory Bowel Disease Patients Display Dysregulated Endoplasmic Reticulum Stress Pathways, Leading to Differential Inflammatory Responses and Dendritic Cell Maturation.

Journal of Crohn's & colitis

Rees WD and Stahl M and Jacobson K and Bressler B and Sly LM and Vallance BA and Steiner TS

DOI: 10.1093/ecco-jcc/jjz194 PubMed: 31796949

07 / 2020

135 THE GEM PROJECT: DIETARY PATTERNS ARE ASSOCIATED WITH MICROBIOME COMPOSITION AND INTESTINAL INFLAMMATION IN HEALHY FIRST-DEGREE RELATIVES OF CROHN'S DISEASE PATIENTS

Gastroenterology

Gila Sasson and Williams Turpin and Juan Antonio Raygoza Garay and Namita Power and Michelle I. Smith and David S. Guttman and Sun-Ho Lee and Anne M. Griffiths and Hien Q. Huynh and Levinus A. Dieleman and Remo Panaccione and A. Hillary Steinhart and Mark S. Silverberg and Guy L. Aumais and Ernest G. Seidman and Kevan Jacobson and David R. Mack and Sanjay K. Murthy and John K. Marshall and Maria T. Abreu and Paul Moayyedi and Kenneth Croitoru

DOI: 10.1016/s0016-5085(20)30749-6

05 / 2020

Mo1132 TLR4 SIGNALING PROTECTS THE INTESTINAL EPITHELIUM FROM TNFa DRIVEN CELL DEATH AND BARRIER DISRUPTION DURING SALMONELLA TYPHIMURIUM INDUCED COLITIS

Gastroenterology

Qin Yu and Kevin Tsai and Shauna M. Crowley and Caixia Ma and Dean Tian and Kevan Jacobson and Bruce Vallance

DOI: 10.1016/s0016-5085(20)32673-1

05 / 2020

398 THE GEM PROJECT: IDENTIFICATION OF A SERUM PROTEOMIC SIGNATURE ASSOCIATED WITH RISK OF FUTURE CROHN'S DISEASE ONSET IN A COHORT OF HEALTHY AT-RISK INDIVIDUALS

Gastroenterology

Juan Antonio Raygoza Garay and Williams Turpin and Michelle I. Smith and Ashleigh Goethel and Hien Q. Huynh and Anne M. Griffiths and Dan Turner and A. Hillary Steinhart and Ernest G. Seidman and David R. Mack and Kevan Jacobson and Mark Ropeleski and Maria Cino and Guy L. Aumais and Remo Panaccione and Colette Deslandres and Iwona Wrobel and Jonas Halfvarson and Kenneth Croitoru

DOI: 10.1016/s0016-5085(20)30864-7

05 / 2020

Su1980 THE GEM PROJECT: IMPAIRED GUT BARRIER FUNCTION IS ASSOCIATED WITH FUTURE DEVELOPMENT OF CROHN'S DISEASE EVEN IN THE PRESENCE OR ABSCENCE OF PRECLINICAL INFLAMMATION IN ASYMPTOMATIC FIRST-DEGREE RELATIVES OF CROHN'S PATIENTS

Gastroenterology

Sun-Ho Lee and Williams Turpin and Juan Antonio Raygoza Garay and Karen Madsen and Jon Meddings and Larbi Bedrani and Namita Power and Wei Xu and Michelle I. Smith and Anne M. Griffiths and Paul Moayyedi and Dan Turner and Ernest G. Seidman and A. Hillary Steinhart and John K. Marshall and Kevan Jacobson and David R. Mack and Hien Q. Huynh and Charles N. Bernstein and Andrew Paterson and Kenneth Croitoru

DOI: 10.1016/s0016-5085(20)32506-3

05 / 2020

A171 MAGNETIC RESONANCE IMAGING IN CHILDREN WITH EARLY ONSET INFLAMMATORY BOWEL DISEASE- A RETROSPECTIVE COHORT STUDY

Journal of the Canadian Association of Gastroenterology

A Eindor and L Meleady and A Lakhani and S Lawrence and G Krikler and Z Hamilton and K Jacobson

DOI: 10.1093/jcag/gwz047.170

02 / 2020

A202 DYSREGULATED ENDOPLASMIC RETICULUM STRESS PATHWAYS IN COLON-DERIVED ENTEROIDS FROM INFLAMMATORY BOWEL DISEASE PATIENTS DRIVE DC MATURATION LEADING TO A PRO-INFLAMMATORY PHENOTYPE

Journal of the Canadian Association of Gastroenterology

W D Rees and M Stahl and K Jacobson and B Bressler and L M Sly and B Vallance and T Steiner

DOI: 10.1093/jcag/gwz047.201

02 / 2020

A65 VARIATION IN THE CARE OF CHILDREN WITH INFLAMMATORY BOWEL DISEASE: A CANGIEC POPULATION-BASED STUDY

Journal of the Canadian Association of Gastroenterology

E Kuenzig and H Singh and A Bitton and G G Kaplan and M W Carroll and A Otley and T A Stukel and S Spruin and A Griffiths and D Mack and K Jacobson and G C Nguyen and L Targownik and W El-Matary and S Nasiri and E I Benchimol

DOI: 10.1093/jcag/gwz047.064

02 / 2020

A26 PEDIATRIC-ONSET INFLAMMATORY BOWEL DISEASE INCREASES THE RISK OF VENOUS THROMBOEMBOLISM: A CANGIEC POPULATION-BASED STUDY

Journal of the Canadian Association of Gastroenterology

E Kuenzig and H Singh and A Bitton and G G Kaplan and M W Carroll and A Otley and T A Stukel and S Spruin and Z Nugent and D Tanyingoh and Y Cui and C Filliter and S Coward and A Griffiths and D Mack and K Jacobson and G C Nguyen and L Targownik and W El-Matary and E I Benchimol

DOI: 10.1093/jcag/gwz047.025

02 / 2020

P587 Adalimumab in pediatric Crohns disease: A long-term multi-centre real-world experience

Journal of Crohn's and Colitis

S Lawrence and H Huynh and W El-Matary and J DeBruyn and M Carroll and E Wine and J Chan and K Jacobson

DOI: 10.1093/ecco-jcc/jjz203.715

01 / 2020

P552 Withdrawal of immunomodulator medications (IM) in children with inflammatory bowel disease on combination therapy of IM and biologics

Journal of Crohn's and Colitis

A Chandrakumar and M Carroll and J deBruyn and K Jacobson and H Huynh and E Wine and S Lawrence and W El-Matary

DOI: 10.1093/ecco-jcc/jjz203.680

01 / 2020

High body mass index is not associated with increased treatment failure in infliximab treated pediatric patients with inflammatory bowel disease

JGH Open

Rodin, I. and Chan, J. and Meleady, L. and Hii, C. and Lawrence, S. and Jacobson, K.

DOI: 10.1002/jgh3.12277

Fiber and prebiotic interventions in pediatric inflammatory bowel disease: What role does the gut microbiome play?

Nutrients

Healey, G.R. and Celiberto, L.S. and Lee, S.M. and Jacobson, K.

DOI: 10.3390/nu12103204

A dose-response and meta-analysis of phytosterols consumption on liver enzymes: Evidence from randomized clinical trials

Nutrition and Food Science

Tajik, S. and Jacobson, K. and Talaei, S. and Kord-Varkaneh, H. and Noormohammadi, Z. and Salehi-Sahlabadi, A. and Pezeshki, M. and Rahmani, J. and Hekmatdoost, A.

DOI: 10.1108/NFS-06-2019-0182

In Reply to (Meta-analysis on obesity and risk of inflammatory bowel disease: re-analysis is needed)

Obesity Reviews

Rahmani, J. and Kord Varkaneh, H. and Hekmatdoost, A. and Thompson, J. and Clark, C. and Salehisahlabadi, A. and Day, A.S. and Jacobson, K.

DOI: 10.1111/obr.12956

Direct Clinical Evidence Recommending the Use of Proteinase K or Dithiothreitol to Pretreat Sputum for Detection of SARS-CoV-2

Frontiers in Medicine

Peng, J. and Lu, Y. and Song, J. and Vallance, B.A. and Jacobson, K. and Yu, H.B. and Sun, Z.

DOI: 10.3389/fmed.2020.549860

Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohns disease subjects

BMC Medical Genetics

Turpin, W. and Bedrani, L. and Espin-Garcia, O. and Xu, W. and Silverberg, M.S. and Smith, M.I. and Garay, J.A.R. and Lee, S.-H. and Guttman, D.S. and Griffiths, A. and Moayyedi, P. and Panaccione, R. and Huynh, H. and Steinhart, H.A. and Aumais, G. and Dieleman, L.A. and Turner, D. and Abreu, M. and Beck, P. and Bernstein, C. and Croitoru, K. and Feagan, B. and Guttman, D. and Jacobson, K. and Kaplan, G. and Krause, D.O. and Madsen, K. and Marshall, J. and Seidman, E. and Silverberg, M. and Stadnyk, A. and Steinhart, A.H. and Surette, M. and Walters, T. and Vallance, B. and Bitton, A. and Cino, M. and Critch, J. and Denson, L. and Deslandres, C. and El-Matary, W. and Herfarth, H. and Higgins, P. and Hyams, J. and Mack, D. and McGrath, J. and Otley, A. and Panancionne, R. and Baldassano, R. and Griffiths, A.M. and Hedin, C. and Hussey, S. and Hyams, H. and Keljo, D. and Kevans, D. and Lees, C. and Murthy, S. and Parekh, N. and Plamondon, S. and Radford-Smith, G. and Ropeleski, M. and Rosh, J. and Rubin, D. and Schultz, M. and Siegel, C. and Snapper, S. and Paterson, A.D. and Croitoru, K.

DOI: 10.1186/s12881-020-01115-w

Phenotypic Variation in Paediatric Inflammatory Bowel Disease by Age: A Multicentre Prospective Inception Cohort Study of the Canadian Children IBD Network

Journal of Crohn's and Colitis

Dhaliwal, J. and Walters, T.D. and Mack, D.R. and Huynh, H.Q. and Jacobson, K. and Otley, A.R. and Debruyn, J. and El-Matary, W. and Deslandres, C. and Sherlock, M.E. and Critch, J.N. and Bax, K. and Seidman, E. and Jantchou, P. and Ricciuto, A. and Rashid, M. and Muise, A.M. and Wine, E. and Carroll, M. and Lawrence, S. and Van Limbergen, J. and Benchimol, E.I. and Church, P. and Griffiths, A.M.

DOI: 10.1093/ecco-jcc/jjz106

Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts

Gut Microbes

Yang, H. and Mirsepasi-Lauridsen, H.C. and Struve, C. and Allaire, J.M. and Sivignon, A. and Vogl, W. and Bosman, E.S. and Ma, C. and Fotovati, A. and Reid, G.S. and Li, X. and Petersen, A.M. and Gouin, S.G. and Barnich, N. and Jacobson, K. and Yu, H.B. and Krogfelt, K.A. and Vallance, B.A.

DOI: 10.1080/19490976.2020.1847976

Capsule Endoscopy Complements Magnetic Resonance Enterography and Endoscopy in Evaluating Small Bowel Crohn's Disease.

Journal of the Canadian Association of Gastroenterology

Prichard DO and Hamilton Z and Savage T and Smyth M and Penner C and Lakhani A and Carroll MW and Al Sarkhy A and Lemberg DA and Enns R and Jamieson D and Jacobson K

DOI: 10.1093/jcag/gwz028 PubMed: 33241181

09 / 2019

Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn's disease patients

World Journal of Gastroenterology

Foster, A.J. and Smyth, M. and Lakhani, A. and Jung, B. and Brant, R.F. and Jacobson, K.

DOI: 10.3748/wjg.v25.i10.1266

Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease

Inflammatory Bowel Diseases

Turpin, W. and Espin-Garcia, O. and Bedrani, L. and Madsen, K. and Meddings, J.B. and Raygoza Garay, J.A. and Silverberg, M.S. and Smith, M.I. and Griffiths, A.M. and Moayyedi, P. and Marshall, J.K. and Mack, D. and Seidman, E.G. and Ropeleski, M. and Feagan, B.G. and Jacobson, K. and Turner, D. and Walters, T. and Paterson, A.D. and Xu, W. and Croitoru, K.

DOI: 10.1093/ibd/izz116

Clinical disease activity and endoscopic severity correlate poorly in children newly diagnosed with Crohn's disease

Gastrointestinal Endoscopy

Carman, N. and Tomalty, D. and Church, P.C. and Mack, D.R. and Benchimol, E.I. and Otley, A.R. and Jacobson, K. and Huynh, H.Q. and DeBruyn, J.C. and El-Matary, W. and Sherlock, M. and Van Limbergen, J. and Griffiths, A.M. and Walters, T.D.

DOI: 10.1016/j.gie.2018.09.025

Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells

Gastroenterology

Cook, L. and Stahl, M. and Han, X. and Nazli, A. and MacDonald, K.N. and Wong, M.Q. and Tsai, K. and Dizzell, S. and Jacobson, K. and Bressler, B. and Kaushic, C. and Vallance, B.A. and Steiner, T.S. and Levings, M.K.

DOI: 10.1053/j.gastro.2019.09.002

Higher postinduction infliximab serum trough levels are associated with healing of fistulizing perianal Crohn's disease in children

Inflammatory Bowel Diseases

El-Matary, W. and Walters, T.D. and Huynh, H.Q. and Debruyn, J. and MacK, D.R. and Jacobson, K. and Sherlock, M.E. and Church, P. and Wine, E. and Carroll, M.W. and Benchimol, E.I. and Lawrence, S. and Griffiths, A.M.

DOI: 10.1093/ibd/izy217

Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-Based Data

Gastroenterology

Coward, S. and Clement, F. and Benchimol, E.I. and Bernstein, C.N. and Avina-Zubieta, J.A. and Bitton, A. and Carroll, M.W. and Hazlewood, G. and Jacobson, K. and Jelinski, S. and Deardon, R. and Jones, J.L. and Kuenzig, M.E. and Leddin, D. and McBrien, K.A. and Murthy, S.K. and Nguyen, G.C. and Otley, A.R. and Panaccione, R. and Rezaie, A. and Rosenfeld, G. and Pea-Snchez, J.N. and Singh, H. and Targownik, L.E. and Kaplan, G.G.

DOI: 10.1053/j.gastro.2019.01.002

Management of Paediatric Patients with Medically Refractory Crohn's Disease Using Ustekinumab: A Multi-Centred Cohort Study

Journal of Crohn's and Colitis

Chavannes, M. and Martinez-Vinson, C. and Hart, L. and Kaniki, N. and Chao, C.-Y. and Lawrence, S. and Jacobson, K. and Hugot, J.-P. and Viala, J. and Deslandres, C. and Jantchou, P. and Seidman, E.G.

DOI: 10.1093/ecco-jcc/jjy206

Body mass index and risk of inflammatory bowel disease: A systematic review and dose-response meta-analysis of cohort studies of over a million participants

Obesity Reviews

Rahmani, J. and Kord-Varkaneh, H. and Hekmatdoost, A. and Thompson, J. and Clark, C. and Salehisahlabadi, A. and Day, A.S. and Jacobson, K.

DOI: 10.1111/obr.12875

Rural and urban disparities in the care of canadian patients with inflammatory bowel disease: A population-based study

Clinical Epidemiology

Benchimol, E.I. and Kuenzig, M.E. and Bernstein, C.N. and Nguyen, G.C. and Guttmann, A. and Jones, J.L. and Potter, B.K. and Targownik, L.E. and Catley, C.A. and Nugent, Z.J. and Tanyingoh, D. and Mojaverian, N. and Underwood, F.E. and Siddiq, S. and Otley, A.R. and Bitton, A. and Carroll, M.W. and Debruyn, J.C. and Dummer, T.J.B. and El-Matary, W. and Griffiths, A.M. and Jacobson, K. and Leddin, D. and Lix, L.M. and Mack, D.R. and Murthy, S.K. and Pea-Snchez, J.N. and Singh, H. and Kaplan, G.G.

DOI: 10.2147/CLEP.S178056

Long-term Outcomes of Infliximab Use for Pediatric Crohn Disease: A Canadian Multicenter Clinical Practice Experience

Journal of Pediatric Gastroenterology and Nutrition

DeBruyn, J.C. and Jacobson, K. and El-Matary, W. and Carroll, M. and Wine, E. and Wrobel, I. and Van Woudenberg, M. and Huynh, H.Q.

DOI: 10.1097/MPG.0000000000001672

Frontline defenders: Goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and disease

American Journal of Physiology - Gastrointestinal and Liver Physiology

Allaire, J.M. and Morampudi, V. and Crowley, S.M. and Stahl, M. and Yu, H. and Bhullar, K. and Knodler, L.A. and Bressler, B. and Jacobson, K. and Vallance, B.A.

DOI: 10.1152/ajpgi.00181.2017

Dietary patterns and risk of ulcerative colitis: a case"control study

Journal of Human Nutrition and Dietetics

Rashvand, S. and Behrooz, M. and Samsamikor, M. and Jacobson, K. and Hekmatdoost, A.

DOI: 10.1111/jhn.12544

Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome

Immunology

Celiberto, L.S. and Graef, F.A. and Healey, G.R. and Bosman, E.S. and Jacobson, K. and Sly, L.M. and Vallance, B.A.

DOI: 10.1111/imm.12939

The Muc2 mucin coats murine paneth cell granules and facilitates their content release and dispersion

American Journal of Physiology - Gastrointestinal and Liver Physiology

Stahl, M. and Tremblay, S. and Montero, M. and Vogl, W. and Xia, L. and Jacobson, K. and Menendez, A. and Vallance, B.A.

DOI: 10.1152/ajpgi.00264.2017

Ulcerative Colitis-Associated Escherichia Coli Colonize the Intestinal Mucosa of Susceptible Host and Promote Colitis via Hemolysin Production

Gastroenterology

Hengameh Chlo Mirsepasi-Lauridsen and Hyungjun Yang and Else Bosman and Carsten Struve and Hongbing Yu and Xiujuan Wu and Caixia Ma and Abbas Fotovati and Andreas M. Petersen and Kevan Jacobson and Karen A. Krogfelt and Bruce Vallance

DOI: 10.1016/s0016-5085(17)32838-x

04 / 2017

Capsule Endoscopy Complements Magnetic Resonance Enterography and Ileo-Colonoscopy in the Evaluation of Suspected Small Bowel Crohns Disease in Pediatric Patients

Gastroenterology

David O. Prichard and Zachary Hamilton and Thomas Savage and Matthew Smyth and Carlie Penner and Alam Lakhani and Matthew Carroll and Ahmed A. Alsarkhy and Daniel Lemberg and Robert A. Enns and Robert J. Prosser and Daniel Jamieson and Kevan Jacobson

DOI: 10.1016/s0016-5085(17)32196-0

04 / 2017

The Prevalence and Predictors of Anti-TNF Failure in a Population based Sample of Persons with IBD

Gastroenterology

Laura E. Targownik and Charles N. Bernstein and Harminder Singh and Aruni Tennakoon and Stella leung and Zoann Nugent and Lisa Lix and Kevan Jacobson and Juan-Nicolas Pena-Sanchez and Gilaad Kaplan

DOI: 10.1016/s0016-5085(17)31463-4

04 / 2017

Pneumocystis jirovecii pneumonia in pediatric inflammatory bowel disease: A case report and literature review

Frontiers in Pediatrics

Lawrence, S.J. and Sadarangani, M. and Jacobson, K.

DOI: 10.3389/fped.2017.00161

Repression of Salmonella host cell invasion by aromatic small molecules from the human fecal metabolome

Applied and Environmental Microbiology

Peixoto, R.J.M. and Alves, E.S. and Wang, M. and Ferreira, R.B.R. and Granato, A. and Han, J. and Gill, H. and Jacobson, K. and Lobo, L.A. and Domingues, R.M.C.P. and Borchers, C.H. and Davies, J.E. and Brett Finlay, B. and Antunes, L.C.M.

DOI: 10.1128/AEM.01148-17

Tricellular tight junction protein tricellulin is targeted by the enteropathogenic Escherichia coli effector EspG1, leading to epithelial barrier disruption

Infection and Immunity

Morampudi, V. and Graef, F.A. and Stahl, M. and Dalwadi, U. and Conlin, V.S. and Huang, T. and Vallance, B.A. and Yu, H.B. and Jacobson, K.

DOI: 10.1128/IAI.00700-16

Transition clinic attendance is associated with improved beliefs and attitudes toward medicine in patients with inflammatory bowel disease

World Journal of Gastroenterology

Fu, N. and Jacobson, K. and Round, A. and Evans, K. and Qian, H. and Bressler, B.

DOI: 10.3748/wjg.v23.i29.5405

Rural and Urban Residence during Early Life is Associated with a Lower Risk of Inflammatory Bowel Disease: A Population-Based Inception and Birth Cohort Study

American Journal of Gastroenterology

Benchimol, E.I. and Kaplan, G.G. and Otley, A.R. and Nguyen, G.C. and Underwood, F.E. and Guttmann, A. and Jones, J.L. and Potter, B.K. and Catley, C.A. and Nugent, Z.J. and Cui, Y. and Tanyingoh, D. and Mojaverian, N. and Bitton, A. and Carroll, M.W. and Debruyn, J. and Dummer, T.J.B. and El-Matary, W. and Griffiths, A.M. and Jacobson, K. and Kuenzig, M.E. and Leddin, D. and Lix, L.M. and Mack, D.R. and Murthy, S.K. and Snchez, J.N.P. and Singh, H. and Targownik, L.E. and Vutcovici, M. and Bernstein, C.N.

DOI: 10.1038/ajg.2017.208

Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development

Scientific Reports

Bhinder, G. and Allaire, J.M. and Garcia, C. and Lau, J.T. and Chan, J.M. and Ryz, N.R. and Bosman, E.S. and Graef, F.A. and Crowley, S.M. and Celiberto, L.S. and Berkmann, J.C. and Dyer, R.A. and Jacobson, K. and Surette, M.G. and Innis, S.M. and Vallance, B.A.

DOI: 10.1038/srep45274

Concomitant Therapy with Immunomodulator Enhances Infliximab Durability in Pediatric Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Cheng, J. and Hamilton, Z. and Smyth, M. and Barker, C. and Israel, D. and Jacobson, K.

DOI: 10.1097/MIB.0000000000001212

Allied Health Professional Support in Pediatric Inflammatory Bowel Disease: A Survey from the Canadian Children Inflammatory Bowel Disease Network - A Joint Partnership of CIHR and the CH.I.L.D. Foundation

Canadian Journal of Gastroenterology and Hepatology

El-Matary, W. and Benchimol, E.I. and MacK, D. and Huynh, H.Q. and Critch, J. and Otley, A. and Deslandres, C. and Jacobson, K. and Debruyn, J. and Carroll, M.W. and Wine, E. and Van Limbergen, J. and Sherlock, M. and Bax, K. and Lawrence, S. and Seidman, E. and Issenman, R. and Walters, T.D. and Church, P. and Griffiths, A.M.

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Trends in epidemiology of pediatric inflammatory bowel disease in Canada: Distributed network analysis of multiple population-based provincial health administrative databases

American Journal of Gastroenterology

Benchimol, E.I. and Bernstein, C.N. and Bitton, A. and Carroll, M.W. and Singh, H. and Otley, A.R. and Vutcovici, M. and El-Matary, W. and Nguyen, G.C. and Griffiths, A.M. and Mack, D.R. and Jacobson, K. and Mojaverian, N. and Tanyingoh, D. and Cui, Y. and Nugent, Z.J. and Coulombe, J. and Targownik, L.E. and Jones, J.L. and Leddin, D. and Murthy, S.K. and Kaplan, G.G.

DOI: 10.1038/ajg.2017.97

Association of host genome with intestinal microbial composition in a large healthy cohort

Nature Genetics

Williams Turpin and GEM Project Research Consortium and Osvaldo Espin-Garcia and Wei Xu and Mark S Silverberg and David Kevans and Michelle I Smith and David S Guttman and Anne Griffiths and Remo Panaccione and Anthony Otley and Lizhen Xu and Konstantin Shestopaloff and Gabriel Moreno-Hagelsieb and Andrew D Paterson and Kenneth Croitoru

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10 / 2016

Activity of SHIP, Which Prevents Expression of Interleukin 1, Is Reduced in Patients with Crohn's Disease

Gastroenterology

Ngoh, E.N. and Weisser, S.B. and Lo, Y. and Kozicky, L.K. and Jen, R. and Brugger, H.K. and Menzies, S.C. and McLarren, K.W. and Nackiewicz, D. and Van Rooijen, N. and Jacobson, K. and Ehses, J.A. and Turvey, S.E. and Sly, L.M.

DOI: 10.1053/j.gastro.2015.09.049

Pediatric Inflammatory Bowel Disease among South Asians Living in British Columbia, Canada: A Distinct Clinical Phenotype

Inflammatory Bowel Diseases

Carroll, M.W. and Hamilton, Z. and Gill, H. and Simkin, J. and Smyth, M. and Espinosa, V. and Bressler, B. and Jacobson, K.

DOI: 10.1097/MIB.0000000000000651

The goblet cell-derived mediator RELM- drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis

Mucosal Immunology

Morampudi, V. and Dalwadi, U. and Bhinder, G. and Sham, H.P. and Gill, S.K. and Chan, J. and Bergstrom, K.S.B. and Huang, T. and Ma, C. and Jacobson, K. and Gibson, D.L. and Vallance, B.A.

DOI: 10.1038/mi.2015.140

Ulcerative Colitis-Associated Escherichia coli Colonize the Ileum and Cecum of Infected Mice by Adhering to the Intestinal Epithelium

Gastroenterology

Hengameh Chlo{\'{e}} Lauridsen and Hyungjun Yang and Else Bosman and Hongbing Yu and Xiujuan Wu and Caixia Ma and Carsten Struve and Andreas M. Petersen and Karen A. Krogfelt and Kevan Jacobson and Bruce Vallance

DOI: 10.1016/s0016-5085(15)32421-5

04 / 2015

Dietary vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium-induced colitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Ryz, N.R. and Lochner, A. and Bhullar, K. and Ma, C. and Huang, T. and Bhinder, G. and Bosman, E. and Wu, X. and Innis, S.M. and Jacobson, K. and Vallance, B.A.

DOI: 10.1152/ajpgi.00006.2015

Prevalence and risk factors of helicobacter pylori infection in saudi children: A three-year prospective controlled study

Helicobacter

Hasosah, M. and Satti, M. and Shehzad, A. and Alsahafi, A. and Sukkar, G. and Alzaben, A. and Sunaid, A. and Ahmed, A. and Althubiti, S. and Mufti, A. and Jacobson, K.

DOI: 10.1111/hel.12172

Vasoactive intestinal polypeptide promotes intestinal barrier homeostasis and protection against colitis in mice

PLoS ONE

Wu, X. and Conlin, V.S. and Morampudi, V. and Ryz, N.R. and Nasser, Y. and Bhinder, G. and Bergstrom, K.S. and Yu, H.B. and Waterhouse, C.C.M. and Buchan, A.M.J. and Popescu, O.E. and Gibson, W.T. and Waschek, J.A. and Vallance, B.A. and Jacobson, K.

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Treatment Profile of Pediatric Inflammatory Bowel Disease in Saudi Arabia: Issues in Treatment Adherence

Advances in Pharmacology and Pharmacy

Mohammed Hasosah and Mohammed El Mouzan and Omar Saadah and Khalid Al-Saleem and Abdulrahman Al-Hussaini and Ali Al Mehaidib and Badr Al Saleem and Khalid Alquair and Kevan Jacobson

DOI: 10.13189/app.2015.030402

Vasoactive intestinal peptide prevents PKCe-induced intestinal epithelial barrier disruption during EPEC infection

American Journal of Physiology - Gastrointestinal and Liver Physiology

Morampudi, V. and Conlin, V.S. and Dalwadi, U. and Wu, X. and Marshall, K.C. and Nguyen, C. and Vallance, B.A. and Jacobson, K.

DOI: 10.1152/ajpgi.00195.2014

The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects

Genes and Immunity

Ngoh, E.N. and Brugger, H.K. and Monajemi, M. and Menzies, S.C. and Hirschfeld, A.F. and Del Bel, K.L. and Jacobson, K. and Lavoie, P.M. and Turvey, S.E. and Sly, L.M.

DOI: 10.1038/gene.2015.30

Maternal exposure to fish oil primes offspring to harbor intestinal pathobionts associated with altered immune cell balance

Gut Microbes

Gibson, D.L. and Gill, S.K. and Brown, K. and Tasnim, N. and Ghosh, S. and Innis, S. and Jacobson, K.

DOI: 10.1080/19490976.2014.997610

C reactive protein as a predictor of response to infliximab in pediatric Crohns disease

Journal of Crohn's and Colitis

A. Al-Sahafi and K. Jacobson and M. Smyth

DOI: 10.1016/s1873-9946(14)50084-0

09 / 2014

Detecting inflammation in pediatric inflammatory bowel disease: the role of fecal calprotectin and its impact on management

Journal of Crohn's and Colitis

A.J. Foster and K. Jacobson

DOI: 10.1016/s1873-9946(14)50074-8

09 / 2014

The Influence of Adolescent Transition Clinics on the Attitudes and Beliefs in Medicine in Patients With Inflammatory Bowel Disease

Gastroenterology

Nancy Fu and Kevan Jacobson and Andrew M. Round and Kathi Evans and Hong Qian and Brian Bressler

DOI: 10.1016/s0016-5085(14)62816-x

05 / 2014

Antivirulence activity of the human gut metabolome

mBio

Caetano M. Antunes, L. and McDonald, J.A.K. and Schroeter, K. and Carlucci, C. and Ferreira, R.B.R. and Wang, M. and Yurist-Doutsch, S. and Hira, G. and Jacobson, K. and Davies, J. and Allen-Vercoe, E. and Brett Finlay, B.

DOI: 10.1128/mBio.01183-14

Attainment of Steroid-Free Clinical Remission and Normal Growth Among Canadian Children with Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Walters Thomas and Benchimol Eric and Jacobson Kevan and El-Matary Wael and Deslandres Colette and Huynh Hien and Church Peter and Carroll Matthew and Wine Eytan and Mack David and Griffiths Anne

DOI: 10.1097/01.mib.0000456870.74875.ed

25-hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: A randomized controlled study

Journal of Pediatrics

Wingate, K.E. and Jacobson, K. and Issenman, R. and Carroll, M. and Barker, C. and Israel, D. and Brill, H. and Weiler, H. and Barr, S.I. and Li, W. and Lyon, M.R. and Green, T.J.

DOI: 10.1016/j.jpeds.2013.11.071

Role of omega-6 and omega-3 fatty acids in inflammatory bowel disease

AAPS Advances in the Pharmaceutical Sciences Series

Jacobson, K. and Calder, P.C.

DOI: 10.1007/978-3-319-06151-1_5

Intestinal epithelium-specific MyD88 signaling impacts host susceptibility to infectious colitis by promoting protective goblet cell and antimicrobial responses

Infection and Immunity

Bhinder, G. and Stahl, M. and Sham, H.P. and Crowley, S.M. and Morampudi, V. and Dalwadi, U. and Ma, C. and Jacobson, K. and Vallance, B.A.

DOI: 10.1128/IAI.02045-14

DNBS/TNBS colitis models: Providing insights into inflammatory bowel disease and effects of dietary fat

Journal of Visualized Experiments

Morampudi, V. and Bhinder, G. and Wu, X. and Dai, C. and Sham, H.P. and Vallance, B.A. and Jacobson, K.

DOI: 10.3791/51297

Pediatric inflammatory bowel disease in the western region of Saudi Arabia. A retrospective analysis.

Saudi Medical Journal

Hasosah MY and Sukkar GA and Alsahafi AF and Kutbi SY and Alzabn AA and Jacobson K

PubMed: 23756933

06 / 2013

Inflammatory Bowel Disease in the Pediatric South Asian Population of British Columbia, Canada: A Distinct and Severe Phenotype

Gastroenterology

Matthew W. Carroll and Hira S. Gill and Jonathan Simkin and Lee-Ann M. Carroll and Vered Pinsk and Victor M. Espinosa and Brian Bressler and Kevan Jacobson

DOI: 10.1016/s0016-5085(13)62389-6

05 / 2013

Altered intestinal epithelial homeostasis in mice with a target mutation in the gene encoding vasoactive intestinal peptide (VIP)

Gastroenterology

Xiujuan Wu and Kevan Jacobson

DOI: 10.1016/s0016-5085(13)60583-1

05 / 2013

The Relationship Between Common IBD-Associated Risk Alleles and Intestinal Permeability in a Cohort of Healthy First Degree Relatives of Individuals With Crohn's Disease

Gastroenterology

David Kevans and Karen Madsen and Mark S. Silverberg and Wei Xu and Konstantin Shestopaloff and Ummiye Venus Onay and Andrew D. Paterson and Anne M. Griffiths and Paul Moayyedi and Mark J. Ropeleski and Paul L. Beck and Charles N. Bernstein and Alain Bitton and Levinus A. Dieleman and David S. Guttman and Hien Q. Huynh and Kevan Jacobson and Gilaad G. Kaplan and John K. Marshall and Remo Panaccione and Ernest G. Seidman and Kathy Siminovitch and Denis Snider and Andrew Stadnyk and A. Hillary Steinhart and Michael Surette and Dan Turner and Bruce Vallance and Thomas D. Walters and Ken Croitoru

DOI: 10.1016/s0016-5085(13)63107-8

05 / 2013

The Citrobacter rodentium Mouse Model: Studying Pathogen and Host Contributions to Infectious Colitis

Journal of Visualized Experiments

Ganive Bhinder and Ho Pan Sham and Justin M. Chan and Vijay Morampudi and Kevan Jacobson and Bruce A. Vallance

DOI: 10.3791/50222

02 / 2013

Clinical nutrition knowledge of gastroenterology fellows: is there anything omitted?

Acta medica Iranica

Eslamian G and Jacobson K and Hekmatdoost A

PubMed: 24338195

Magnetic resonance imaging of the perineum in pediatric patients with inflammatory bowel disease

Canadian Journal of Gastroenterology

Jamieson, D.H. and Shipman, P. and Jacobson, K.

DOI: 10.1155/2013/624141

Changing incidence of inflammatory bowel disease: Environmental influences and lessons learnt from the South Asian population

Frontiers in Pediatrics

Foster, A. and Jacobson, K.

DOI: 10.3389/fped.2013.00034

Pediatric inflammatory bowel disease in the western region of Saudi Arabia. A retrospective analysis

Saudi Medical Journal

Hasosah, M.Y. and Sukkar, G.A. and Alsahafi, A.F. and Kutbi, S.Y. and Alzabn, A.A. and Jacobson, K.

The Citrobacter rodentium mouse model: studying pathogen and host contributions to infectious colitis.

Journal of visualized experiments : JoVE

Bhinder, G. and Sham, H.P. and Chan, J.M. and Morampudi, V. and Jacobson, K. and Vallance, B.A.

Dietary oils modify the host immune response and colonic tissue damage following Citrobacter rodentium infection in mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Hekmatdoost, A. and Wu, X. and Morampudi, V. and Innis, S.M. and Jacobson, K.

DOI: 10.1152/ajpgi.00292.2012

Seroconversion of hepatitis B envelope antigen (HBeAg) by entecavir in a child with chronic hepatitis B

Saudi Journal of Gastroenterology

Hasosah, M.Y. and Ghandourah, H.S. and Alsahafi, A.F. and Sukkar, G. and Jacobson, K.

DOI: 10.4103/1319-3767.96465

Perinatal cytomegalovirus hepatitis in Saudi infants: A case series

Saudi Journal of Gastroenterology

Hasosah, M.Y. and Kutbi, S.Y. and Al-Amri, A.W. and Alsahafi, A.F. and Sukkar, G.A. and Alghamdi, K.J. and Jacobson, K.

DOI: 10.4103/1319-3767.96461

Gastroesophageal reflux disease in children and adolescents: When and how to treat

Pediatric Drugs

Carroll, M.W. and Jacobson, K.

DOI: 10.2165/11594360-000000000-00000

Helicobacter pylori in First Nations and recent immigrant populations in Canada

Canadian Journal of Gastroenterology

Jones, N.L. and Chiba, N. and Fallone, C. and Thomson, A. and Hunt, R. and Jacobson, K. and Goodman, K.

DOI: 10.1155/2012/174529

Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses

American Journal of Physiology Gastrointestinal and Liver Physiology

Ryz, N.R. and Patterson, S.J. and Zhang, Y. and Ma, C. and Huang, T. and Bhinder, G. and Wu, X. and Chan, J. and Glesby, A. and Sham, H.P. and Dutz, J.P. and Levings, M.K. and Jacobson, K. and Vallance, B.A.

DOI: 10.1152/ajpgi.00320.2012

Transient appearance of GPI-deficient population in a patient with azathioprine-associated bone marrow aplasia

Annals of Hematology

Al Riyami, A.Z. and Jacobson, K. and Ford, J. and Dalal, B.I.

DOI: 10.1007/s00277-012-1449-7

Induction and Maintenance Therapy With Infliximab for Children With Moderate to Severe Ulcerative Colitis

Clinical Gastroenterology and Hepatology

Jeffrey Hyams and Lakshmi Damaraju and Marion Blank and Jewel Johanns and Cynthia Guzzo and Harland S. Winter and Subra Kugathasan and Stanley Cohen and James Markowitz and Johanna C. Escher and Gigi Veereman"Wauters and Wallace Crandall and Robert Baldassano and Anne Griffiths

DOI: https://doi.org/10.1016/j.cgh.2011.11.026

Mucosa-Associated Lymphoid Tissue Lymphoma of the Lacrimal Gland: Sustained Remission after Eradication of Helicobacter Pylori Infection

Case Reports in Gastrointestinal Medicine

Mohammed Hasosah and Abdullah Baothman and Mohamed Satti and Suzanne Kutbi and Khaled Alghamdi and Kevan Jacobson

DOI: 10.1155/2011/945752

SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis

American Journal of Pathology

McLarren, K.W. and Cole, A.E. and Weisser, S.B. and Voglmaier, N.S. and Conlin, V.S. and Jacobson, K. and Popescu, O. and Boucher, J.-L. and Sly, L.M.

DOI: 10.1016/j.ajpath.2011.03.018

Perinatal lipid nutrition alters early intestinal development and programs the response to experimental colitis in young adult rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Innis, S.M. and Dai, C. and Wu, X. and Buchan, A.M.J. and Jacobson, K.

DOI: 10.1152/ajpgi.00258.2010

Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apcmin mice

Gastroenterology

Xiao, H. and Yin, W. and Khan, M.A. and Gulen, M.F. and Zhou, H. and Sham, H.P. and Jacobson, K. and Vallance, B.A. and Li, X.

DOI: 10.1053/j.gastro.2010.04.043

Esophageal candidiasis in an immunocompetent girl

World Journal of Pediatrics

Hasosah, M.Y. and Showail, M. and Al-sahafi, A. and Satti, M. and Jacobson, K.

DOI: 10.1007/s12519-009-0031-4

Persistent elevated tissue-transglutaminase in cystic fibrosis

Journal of Paediatrics and Child Health

Hasosah, M. and Davidson, G. and Jacobson, K.

DOI: 10.1111/j.1440-1754.2009.01477.x

Canadian Association of Gastroenterology Clinical Practice Guidelines: The Use of Tumour Necrosis Factor-Alpha Antagonist Therapy in Crohns Disease

Canadian Journal of Gastroenterology

Daniel C Sadowski and Charles N Bernstein and Alain Bitton and Ken Croitoru and Richard N Fedorak and Anne Griffiths and the CAG Crohns Consensus Group

DOI: 10.1155/2009/201430

Vasoactive intestinal peptide ameliorates intestinal barrier disruption associated with Citrobacter rodentium-induced colitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Conlin, V.S. and Wu, X. and Nguyen, C. and Dai, C. and Vallance, B.A. and Buchan, A.M.J. and Boyer, L. and Jacobson, K.

DOI: 10.1152/ajpgi.90551.2008

Helicobacter pylori infection in Canadian and related Arctic Aboriginal populations

Canadian Journal of Gastroenterology

Goodman, K.J. and Jacobson, K. and van Zanten, S.V.

DOI: 10.1155/2008/258610

Response to Dr. Rashid and colleagues [4]

American Journal of Gastroenterology

Pinsk, V. and Jacobson, K.

DOI: 10.1111/j.1572-0241.2007.01562_4.x

The effect of dietary oils on cecal microflora in experimental colitis in mice

Indian Journal of Gastroenterology

Hekmatdoost, A. and Feizabadi, M.M. and Djazayery, A. and Mirshafiey, A. and Eshraghian, M.R. and Yeganeh, S.M. and Sedaghat, R. and Jacobson, K.

The effect of dietary oils on cecal microflora in experimental colitis in mice.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

Hekmatdoost A and Feizabadi MM and Djazayery A and Mirshafiey A and Eshraghian MR and Yeganeh SM and Sedaghat R and Jacobson K

PubMed: 19112187

Low prevalence of Helicobacter pylori infection in Canadian children: A cross-sectional analysis

Canadian Journal of Gastroenterology

Segal, I. and Otley, A. and Issenman, R. and Armstrong, D. and Espinosa, V. and Cawdron, R. and Morshed, M.G. and Jacobson, K.

DOI: 10.1155/2008/410176

Improvement in Biomarkers of Bone Formation During Infliximab Therapy in Pediatric Crohn's Disease: Results of the REACH Study

Clinical Gastroenterology and Hepatology

Meena Thayu and Mary B. Leonard and Jeffrey S. Hyams and Wallace V. Crandall and Subra Kugathasan and Anthony R. Otley and Allan Olson and Jewel Johanns and Colleen W. Marano and Robert B. Heuschkel and Gigi Veereman"Wauters and Anne M. Griffiths and Robert N. Baldassano

DOI: 10.1016/j.cgh.2008.07.010

Induction and Maintenance Infliximab Therapy for the Treatment of Moderate-to-Severe Crohns Disease in Children

Gastroenterology

Jeffrey Hyams and Wallace Crandall and Subra Kugathasan and Anne Griffiths and Allan Olson and Jewel Johanns and Grace Liu and Suzanne Travers and Robert Heuschkel and James Markowitz and Stanley Cohen and Harland Winter and Gigi Veereman"Wauters and George Ferry and Robert Baldassano

DOI: 10.1053/j.gastro.2006.12.003

03 / 2007

Dietary Lipids in Early Development and Intestinal Inflammatory Disease

Nutrition Reviews

Innis, S.M. and Jacobson, K.

DOI: 10.1111/j.1753-4887.2007.tb00361.x

Inflammatory bowel disease in the South Asian pediatric population of British Columbia

American Journal of Gastroenterology

Pinsk, V. and Lemberg, D.A. and Grewal, K. and Barker, C.C. and Schreiber, R.A. and Jacobson, K.

DOI: 10.1111/j.1572-0241.2007.01124.x

Canadian pediatric gastroenterology workforce: Current status, concerns and future projections

Canadian Journal of Gastroenterology

Morinville, V. and Drouin, ?. and Lvesque, D. and Espinosa, V.M. and Jacobson, K.

DOI: 10.1155/2007/292054

Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors

American Journal of Physiology - Gastrointestinal and Liver Physiology

Wu, X. and Vallance, B.A. and Boyer, L. and Bergstrom, K.S.B. and Walker, J. and Madsen, K. and O'Kusky, J.R. and Buchan, A.M. and Jacobson, K.

DOI: 10.1152/ajpgi.00173.2007

Differential responses of VIPergic and nitrergic neurons in paediatric patients with Crohn's disease

Autonomic Neuroscience: Basic and Clinical

Boyer, L. and Sidpra, D. and Jevon, G. and Buchan, A.M. and Jacobson, K.

DOI: 10.1016/j.autneu.2007.03.001

Surgical intervention in children with Crohn's disease

International Journal of Colorectal Disease

Leonor, R. and Jacobson, K. and Pinsk, V. and Webber, E. and Lemberg, D.A.

DOI: 10.1007/s00384-007-0281-3

Pediatric gastroenterology - Are you kidding?

Canadian Journal of Gastroenterology

Jacobson, K. and Adams, P.C.

DOI: 10.1155/2007/823540

Upper Gastrointestinal Biopsies and Pediatric Crohns Disease

Journal of Pediatric Gastroenterology and Nutrition

Mohammed Hasosah and Anne Gomez and Gareth Jevon and Kevan Jacobson

DOI: 10.1097/00005176-200610000-00160

10 / 2006

A randomized trial of yoga for adolescents with irritable bowel syndrome

Pain Research and Management

Kuttner, L. and Chambers, C.T. and Hardial, J. and Israel, D.M. and Jacobson, K. and Evans, K.

DOI: 10.1155/2006/731628

Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat

Autonomic Neuroscience: Basic and Clinical

Saunders, P.R. and Miceli, P. and Vallance, B.A. and Wang, L. and Pinto, S. and Tougas, G. and Kamath, M. and Jacobson, K.

DOI: 10.1016/j.autneu.2005.12.002

Dietary lipids and intestinal inflammatory disease

Journal of Pediatrics

Innis, S.M. and Pinsk, V. and Jacobson, K.

DOI: 10.1016/j.jpeds.2006.06.058

Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: Role of mitochondrial associated protein (Map)

Cellular Microbiology

Ma, C. and Wickham, M.E. and Guttman, J.A. and Deng, W. and Walker, J. and Madsen, K.L. and Jacobson, K. and Vogl, W.A. and Finlay, B.B. and Vallance, B.A.

DOI: 10.1111/j.1462-5822.2006.00741.x

The congenital intrahepatic arterioportal fistula syndrome: Elucidation and proposed classification

Journal of Pediatric Gastroenterology and Nutrition

Norton, S.P. and Jacobson, K. and Moroz, S.P. and Culham, G. and Ng, V. and Turner, J. and John, P.

DOI: 10.1097/01.mpg.0000221890.13630.ad

Pediatric Inflammatory Bowel Disease: The British Columbia Experience

Journal of Pediatric Gastroenterology and Nutrition

Vered Pinsk and Daniel A Lemberg and Rosario Leonor and Collin Barker and Richard Schreiber and David M Israel and Kevan Jacobson

DOI: 10.1097/01.mpg.0000182025.84053.ed

10 / 2005

The changing pattern of Pediatric IBD at British Columbias Childrens Hospital

Journal of Pediatric Gastroenterology and Nutrition

Vered Pinsk and Daniel A Lemberg and Collin Barker and Richard Schreiber and David M Israel and Kevan Jacobson

DOI: 10.1097/01.mpg.0000182024.84053.a4

10 / 2005

Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents--an evidence-based evaluation.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie

Bourke B and Ceponis P and Chiba N and Czinn S and Ferraro R and Fischbach L and Gold B and Hyunh H and Jacobson K and Jones NL and Koletzko S and Lebel S and Moayyedi P and Ridell R and Canadian Helicobacter Study Group

PubMed: 16010300

07 / 2005

The changing prevalence of Helicobacter pylori infection in Canadian children: Should screening be performed in high-risk children?

Canadian Journal of Gastroenterology

Jacobson, K.

DOI: 10.1155/2005/840909

Canadian Helicobacter Study Group Consensus Conference: Update on the Approach to Helicobacter Pylori Infection in Children and Adolescents " an Evidence-Based Evaluation

Canadian Journal of Gastroenterology

Nicola L Jones and Philip Sherman and Carlo A Fallone and Nigel Flook and Fiona Smaill and Sander Veldhuyzen van Zanten and Richard Hunt and Alan Thomson and Canadian Helicobacter Study Group

DOI: 10.1155/2005/390932

Myenteric plexus injury and apoptosis in experimental colitis

Autonomic Neuroscience: Basic and Clinical

Boyer, L. and Ghoreishi, M. and Templeman, V. and Vallance, B.A. and Buchan, A.M. and Jevon, G. and Jacobson, K.

DOI: 10.1016/j.autneu.2004.10.006

Clinical quiz

Journal of Pediatric Gastroenterology and Nutrition

Babu, T.G.L. and Jacobson, K.

DOI: 10.1097/01.MPG.0000147132.59353.B9

Endoscopic hemostasis in a neonate with a bleeding duodenal ulcer

Journal of Pediatric Gastroenterology and Nutrition

Babu, T.G.L. and Jacobson, K. and Phang, M. and Riley, M.R. and Barker, C.C.

DOI: 10.1097/01.mpg.0000173602.39271.ff

Erratum: Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents - An evidence-based evaluation (Canadian Journal of Gastroenterology (2005) vol. 19 (7) (399-408))

Canadian Journal of Gastroenterology

Jones, N.L. and Sherman, P. and Fallone, C.A. and Bourke, B. and Ceponis, P. and Chiba, N. and Czinn, S. and Ferraro, R. and Fischbach, L. and Gold, B. and Hyunh, H. and Jacobson, K. and Jones, N. and Koletzko, S. and Lebel, S. and Moayyedi, P. and Ridell, R. and Sherman, P. and van Zanten, S. and Beck, I. and Best, L. and Boland, M. and Bursey, F. and Chaun, H. and Cooper, G. and Craig, B. and Creuzenet, C. and Critch, J. and Govender, K. and Hassall, E. and Kaplan, A. and Keelan, M. and Noad, G. and Robertson, M. and Smith, L. and Stein, M. and Taylor, D. and Walters, T. and Persaud, R. and Whitaker, S. and Woodland, R.

Positron emission tomography in the investigation of pediatric inflammatory bowel disease

Inflammatory Bowel Diseases

Lemberg, D.A. and Issenman, R.M. and Cawdron, R. and Green, T. and Mernagh, J. and Skehan, S.J. and Nahmias, C. and Jacobson, K.

DOI: 10.1097/01.MIB.0000172810.49619.cb

Intramural esophageal hematoma (IEH).

Journal of pediatric gastroenterology and nutrition

Lokesh Babu, T.G. and Jacobson, K.

Intestinal responsiveness to experimental colitis in young rats is altered by maternal diet

American Journal of Physiology - Gastrointestinal and Liver Physiology

Jacobson, K. and Mundra, H. and Innis, S.M.

DOI: 10.1152/ajpgi.00459.2004

Canadian Helicobacter Study Group consensus conference: Update on the management of Helicobacter pylori - An evidence-based evaluation of six topics relevant to clinical outcomes in patients evaluated for H pylori infection

Canadian Journal of Gastroenterology

Hunt, R. and Fallone, C. and Hunt, R. and Fallone, C. and van Zanten, S.V. and Sherman, P. and Smaill, F. and Flook, N. and Thomson, A. and Armstrong, D. and Barkun, A. and Boland, M. and Bosworth, T. and Bourdages, R. and Bridges, R. and Buchan, A. and Bursey, F. and Chaun, H. and Chiba, N. and Chlebo, J. and Cooper, G. and Craig, B. and Deslandres, C. and DeVinney, R. and Erickson, L. and Fallone, C. and Fischbach, L. and Flook, N. and Govender, K. and Hunt, R. and Jacobson, K. and Jones, N. and Klompus, S. and Leduc, N. and Lin, F. and Louw, J. and McCammon, R. and Meddings, J. and Nevin, K. and Noad, G. and Ponich, T. and Serrar, J. and Sherman, P. and Smith, L. and Smith, W. and Spenard, J. and Stein, M. and Streutker, C. and Thomson, P. and Whittaker, S. and Williams, N. and Woodland, R.

DOI: 10.1155/2004/326767

Cytomegalovirus-associated hemophagocytic syndrome in a child with crohn disease receiving azathioprine

Journal of Pediatric Gastroenterology and Nutrition

Babu, T.G.L. and Boctor, D. and Davey, A. and Bond, M.C. and Jacobson, K.

DOI: 10.1097/00005176-200410000-00020

Say goodbye and say hello: The transition from pediatric to adult gastroenterology

Canadian Journal of Gastroenterology

Pinzon, J.L. and Jacobson, K. and Reiss, J.

DOI: 10.1155/2004/474232

Neutrophil granulocytes mediate enteric nervous system injury in a murine model of colitis

Gastroenterology

Kevan Jacobson and Lee C. Boyer and Mehran Ghoreishi and Valerie Templeman and Bruce A. Vallance and Gareth Jevon

DOI: 10.1016/s0016-5085(03)81636-0

04 / 2003

Esophageal Crohn disease in children: A clinical spectrum

Journal of Pediatric Gastroenterology and Nutrition

Ramaswamy, K. and Jacobson, K. and Jevon, G. and Israel, D.

DOI: 10.1097/00005176-200304000-00006

Curcumin attenuates DNB-induced murine colitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Salh, B. and Assi, K. and Templeman, V. and Parhar, K. and Owen, D. and Gmez-Muoz, A. and Jacobson, K.

DOI: 10.1152/ajpgi.00449.2002

Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium

Infection and Immunity

Vallance, B.A. and Deng, W. and Jacobson, K. and Finlay, B.B.

DOI: 10.1128/IAI.71.6.3443-3453.2003

Cholinergic pathways modulate experimental dinitrobenzene sulfonic acid colitis in rats

Autonomic Neuroscience: Basic and Clinical

Miceli, P.C. and Jacobson, K.

DOI: 10.1016/S1566-0702(03)00023-7

Comparison of multidetector CT and barium studies of the small bowel: Inflammatory bowel disease in children

American Journal of Roentgenology

Jamieson, D.H. and Shipman, P.J. and Israel, D.M. and Jacobson, K.

DOI: 10.2214/ajr.180.5.1801211

Etiology of dyspepsia: implications for empirical therapy

Canadian Journal of Gastroenterology

Hunt RH, Fallone C, van Zanten SV, Sherman P, Flook N, Smaill F, Thompson ABR; Canadian Helicobacter Study group (Jacobson K). Etiology of dyspepsia: implications for empirical therapy. Can J Gastroenterol 2002 Sep;16(9):635-41. C (IF 1.4; citations 10)

09 / 2002

Epstein-Barr virus infection in transplant recipients: Summary of a workshop on surveillance, prevention and treatment

Canadian Journal of Infectious Diseases

Allen, U. and Alfieri, C. and Preiksaitis, J. and Humar, A. and Moore, D. and Tapiero, B. and Tellier, R. and Green, M. and Davies, D. and Hbert, D. and Weitzman, S. and Petric, M. and Jacobson, K. and Acott, P. and Arbus, G. and Arnold, S. and Atkinson, P. and Cheung, R. and Cockfield, S. and Deschenes, L. and Dobson, S. and Durno, C. and Fecteau, A. and Geary, D. and Gross, T. and Ngan, B.-Y. and Opavsky, A. and Preiksaitis, J. and Shoker, A. and St-Jean, L. and O'Hare, B. and Petric, M. and Read, S. and Snydman, D. and Fleming, S. and Forgie, S. and Jones, N. and King, S. and Tchervenkov, J. and Tibbles, L.A. and Wasfy, S. and Wolff, J.L.

DOI: 10.1155/2002/634318

Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen Citrobacter rodentium in infected mice

Infection and Immunity

Vallance, B.A. and Deng, W. and De Grado, M. and Chan, C. and Jacobson, K. and Finlay, B.B.

DOI: 10.1128/IAI.70.11.6424-6435.2002

A matched cohort study of feeding practice guidelines for infants weighing less than 1,500 g.

Advances in neonatal care : official journal of the National Association of Neonatal Nurses

Premji, S.S. and Chessell, L. and Paes, B. and Pinelli, J. and Jacobson, K.

DOI: 10.1053/adnc.2002.31510

Evidence-based feeding guidelines for very low-birth-weight infants.

Advances in neonatal care : official journal of the National Association of Neonatal Nurses

Premji, S.S. and Paes, B. and Jacobson, K. and Chessell, L.

DOI: 10.1053/adnc.2002.31511

Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system

Gastroenterology

Huizinga, J.D. and Berezin, I. and Sircar, K. and Hewlett, B. and Donnelly, G. and Bercik, P. and Ross, C. and Algoufi, T. and Fitzgerald, P. and Der, T. and Riddell, R.H. and Collins, S.M. and Jacobson, K.

DOI: 10.1053/gast.2001.21200

Infectious diarrhea in children

Gastroenterology Clinics of North America

Ramaswamy, K. and Jacobson, K.

DOI: 10.1016/S0889-8553(05)70201-6

Gastric acid secretory response in Helicobacter pylori-positive patients with duodenal ulcer disease

Canadian Journal of Gastroenterology

Jacobson, K. and Chiba, N. and Chen, Y. and Barrientos, M. and James, C. and Riddell, R.H. and Hunt, R.H.

DOI: 10.1155/2001/764615

The changing face of celiac disease

Paediatrics and Child Health

Lad, R. and Jacobson, K.

DOI: 10.1093/pch/6.9.644

Stress reactivation colitis and the role of the autonomic nervous system (ANS)

Gastroenterology

Paul Saunders and Markad Kamath and Kevan Jacobson

DOI: 10.1016/s0016-5085(00)85664-4

04 / 2000

Autonomic nervous system (ANS) dysfunction exacerbates inflammation in dextran sulfate (DSS) model of ulcerative colitis

Gastroenterology

Paula C. Miceli and Paul Saunders and Veljko Djuric and Kevan Jacobson

DOI: 10.1016/s0016-5085(00)85665-6

04 / 2000

An unusual cause of recurrent pancreatitis: Duodenal duplication cyst

Canadian Journal of Gastroenterology

Lad, R.J. and Fitzgerald, P. and Jacobson, K.

DOI: 10.1155/2000/152809

Omeprazole for treatment of chronic erosive esophagitis in children: A multicenter study of efficacy, safety, tolerability and dose requirements

The Journal of Pediatrics

Eric Hassall and David Israel and Ross Shepherd and Michael Radke and Agneta Dalvg and Birgitta Skld and Ola Junghard and Per Lundborg

DOI: 10.1067/mpd.2000.109607

18F-fluorodeoxyglucose positron tomography in diagnosis of paediatric inflammatory bowel disease

Lancet

Skehan, S.J. and Issenman, R. and Mernagh, J. and Nahmias, C. and Jacobson, K.

DOI: 10.1016/S0140-6736(99)80021-X

CanadianHelicobacterStudy Group Consensus Conference on the Approach toHelicobacter PyloriInfection in Children and Adolescents

Canadian Journal of Gastroenterology

P Sherman and E Hassall and RH Hunt and CA Fallone and S Veldhuyzen van Zanten and ABR Thomson and Canadian Helicobacter Study Group

DOI: 10.1155/1999/934285

Neuro-modulation of stress-induced reactivation of experimental colitis

Gastroenterology

P.C. Miceli and V. Djuric and K. Jacobson

DOI: 10.1016/s0016-5085(98)84734-3

04 / 1998

Neuroimmune mechanisms in a rat model of stress-induced reactivation of experimental colitis

Gastroenterology

P.C. Miceli and B.A. Vallance and K. Jacobson

DOI: 10.1016/s0016-5085(98)84227-3

04 / 1998

Patients' diets and preferences in a pediatric population with inflammatory bowel disease

Canadian Journal of Gastroenterology

Green, T.J. and Issenman, R.M. and Jacobson, K.

DOI: 10.1155/1998/928706

Positron emission tomography in pediatric inflammatory bowel disease: 40

Journal of Pediatric Gastroenterology and Nutrition

Jacobson, K. and Issenman, R.M. and Radoja, C. and Green, T. and Mernagh, J.R. and Nahmias, C.

DOI: 10.1097/00005176-199710000-00057

The mechanism of altered neural function in a rat model of acute colitis

Gastroenterology

Jacobson, K. and McHugh, K. and Collins, S.M.

DOI: 10.1016/S0016-5085(97)70230-0

Previous inflammation alters the response of the rat colon to stress

Gastroenterology

Collins, S.M. and McHugh, K. and Jacobson, K. and Khan, I. and Riddell, R. and Murase, K. and Weingarten, H.P.

DOI: 10.1016/S0016-5085(96)70012-4

The selective beneficial effects of nitric oxide inhibition in experimental colitis.

The American journal of physiology

Hogaboam CM and Jacobson K and Collins SM and Blennerhassett MG

PubMed: 7537457

04 / 1995

The selective beneficial effects of nitric oxide inhibition in experimental colitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Hogaboam, C.M. and Jacobson, K. and Collins, S.M. and Blennerhassett, M.G.

DOI: 10.1152/ajpgi.1995.268.4.g673

Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat

Gastroenterology

Jacobson, K. and McHugh, K. and Collins, S.M.

DOI: 10.1016/0016-5085(95)90378-X

Interpreting abnormalities in routine liver biochemistry

Canadian Family Physician

Jacobson K, Witt-Sullivan HB. Interpreting abnormalities in routine liver biochemistry. Canadian Family Physician 1992;38:561-566.

Current projects

Epidemiology of paediatric IBD

Current Projects

Examining the role of maternal dietary lipid in modulating epithelial barrier function and intestinal immune response of the young offspring to chemically induced colitis

Current Projects

Determining the effect of intestinal inflammation on neuro-epithelial function in animal models of IBD

Honours & Awards

Canadian Children Inflammatory Bowel Disease Network, CIHR and CH.I.L.D Foundation – 2013

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