Michael Anglesio

PhD

Affiliate Investigator, BC Children's Hospital
Associate Member, Department of Pathology and Laboratory Medicine, University of British Columbia
Member, Women's Health Research Institute
Member, Gynecological Cancer Initiative
Co-Founder, Molecular and Advanced Pathology Core, Department of Pathology and Laboratory Medicine, University of British Columbia

Dr. Anglesio's research has focused primarily on defining subtypes of ovarian cancer. In particular, genomic and protein-based biomarker studies that differentiate types and subtypes of each ovarian cancer histology. Most recently he has been focused on uncovering the mechanism through which endometriosis may become malignant and progress into either clear cell or endometrioid ovarian cancer. In 2017 Dr. Anglesio's group was first to provide evidence that roughly 1/3 of endometriosis frequently harbours cancer-driver mutations, and that these mutations are restricted to only one of two cell types that make up endometriosis.

Academic Affiliations

  • Associate Professor, Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia
  • Research Theme: Healthy Starts
  • Research Group(s): Origins of Child Health and Disease; Pathways to Healthy Birth

Contact Information

Location

Room 275, 2660 Oak Street, Vancouver, British Columbia, Canada, V6H 3Z6

Impact of Anatomical Site on RNA-based molecular subtypes in High -Grade Serous tubo-Ovarian Carcinoma Samples

Reproductive Sciences

Lymph node involvement, surgery and adjuvant treatment in primary Endometrioid Ovarian carcinoma PAtients with eaRly-stage Disease (LEOPARD)-a multinational team initiative

Gynecologic Oncology

DOI: 10.1016/J.YGYNO.2026.04.008

Figure 2 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706368

11 / 2025

Figure 1 from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.30706371

11 / 2025

Data from A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Fabian Coscia and Annelaura B. Nielsen and Melanie Weigert and Karen Watters and Melissa Javellana and Michael Anglesio and S. Diane Yamada and Ricardo R. Lastra and Matthias Mann and Ernst Lengyel

DOI: 10.1158/1078-0432.c.7854080

06 / 2025

Homologous recombination DNA repair dependent survival associations in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis consortium study

Cancer Research

DOI: 10.1158/1538-7445.OVARIAN25-B046

Co-existent endometrial and ovarian carcinoma: molecular and pathological features define low risk entity

International Journal of Gynecological Cancer

DOI: 10.1016/J.IJGC.2025.101957

Cellular origins of mucinous ovarian carcinoma

The Journal of Pathology

DOI: 10.1002/PATH.6407

A Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-24-1763

Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes

Cancer Epidemiology Biomarkers & Prevention

DOI: 10.1158/1055-9965.EPI-24-1143

Abstract B007: Parallel epigenetic and transcriptomic profiling of carcinoma and stroma compartments across major ovarian cancer histotypes

Cancer Research

DOI: 10.1158/1538-7445.OVARIAN25-B007

WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models (vol 31,gaaf021,2025)

Molecular Human Reproduction

DOI: 10.1093/MOLEHR/GAAF036

WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models

Molecular Human Reproduction

DOI: 10.1093/MOLEHR/GAAF021

NGS Compartment Analysis Revealed Uniformity within the Stroma and Type-Specific Differences in the Epithelium of EndometriosisAssociated and High-Grade Serous Ovarian Carcinomas

Reproductive Sciences

Synchronous endometrial and ovarian cancer (SEOC): refining pathological and molecular context to identify 'low-risk SEOC'

International Journal of Gynecological Cancer

DOI: 10.1136/IJGC-2024-IGCS.44

Somatic PTEN and ARID1A loss and endometriosis disease burden: a longitudinal study

Human Reproduction

DOI: 10.1093/HUMREP/DEAE269

Precision medicine opportunities: uniformity across stromal components of ovarian cancer histotype contrasts heterogeneous disease

Cancer Research

DOI: 10.1158/1538-7445.OVARIAN23-B004

Fibroblast Growth Factor Receptors and Ligands in Context of Bevacizumab Response in Ovarian Carcinoma: An Exploratory Analysis of AGO-OVAR11/ICON-7

Laboratory Investigation

DOI: 10.1016/J.LABINV.2023.100321

Association of Somatic Loss of PTEN and ARID1A with Endometriosis Disease Burden: A Longitudinal Study.

REPRODUCTIVE SCIENCES

Cell State of Origin Impacts Development of Distinct Endometriosis-Related Ovarian Carcinoma Histotypes

Cancer Research

DOI: 10.1158/0008-5472.CAN-23-1362

Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer

Journal of Clinical Investigation

DOI: 10.1172/JCI179501

Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-23-3552

Association of Somatic Loss of PTEN and ARID1A with Endometriosis Disease Burden: A Longitudinal Study

Reproductive Sciences

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy with Comorbid Traits

bioRxiv

DOI: 10.1101/2024.11.21.624726

NGS Compartment Analysis Revealed Uniformity within the Stroma and Type-Specific Differences in the Epithelium of EndometriosisAssociated and High-Grade Serous Ovarian Carcinomas.

REPRODUCTIVE SCIENCES

Data from Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Nicola S. Meagher and Kylie L. Gorringe and Matthew Wakefield and Adelyn Bolithon and Chi Nam Ignatius Pang and Derek S. Chiu and Michael S. Anglesio and Kylie-Ann Mallitt and Jennifer A. Doherty and Holly R. Harris and Joellen M. Schildkraut and Andrew Berchuck and Kara L. Cushing-Haugen and Ksenia Chezar and Angela Chou and Adeline Tan and Jennifer Alsop and Ellen Barlow and Matthias W. Beckmann and Jessica Boros and David D.L. Bowtell and Alison H. Brand and James D. Brenton and Ian Campbell and Dane Cheasley and Joshua Cohen and Cezary Cybulski and Esther Elishaev and Ramona Erber and Rhonda Farrell and Anna Fischer and Zhuxuan Fu and Blake Gilks and Anthony J. Gill and Charlie Gourley and Marcel Grube and Paul R. Harnett and Arndt Hartmann and Anusha Hettiaratchi and Claus K. Hgdall and Tomasz Huzarski and Anna Jakubowska and Mercedes Jimenez-Linan and Catherine J. Kennedy and Byoung-Gie Kim and Jae-Weon Kim and Jae-Hoon Kim and Kayla Klett and Jennifer M. Koziak and Tiffany Lai

DOI: 10.1158/1078-0432.c.6532782

04 / 2023

Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study

BRITISH JOURNAL OF CANCER

DOI: 10.1038/S41416-022-02014-Y

Single-cell transcriptomic analysis of endometriosis

NATURE GENETICS

DOI: 10.1038/S41588-022-01254-1

Neuroproliferative dyspareunia in endometriosis and vestibulodynia

Sexual Medicine Reviews

DOI: 10.1093/SXMREV/QEAD033

KRAS mutations and endometriosis burden of disease

JOURNAL OF PATHOLOGY CLINICAL RESEARCH

DOI: 10.1002/CJP2.317

CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study

CANCER

DOI: 10.1002/CNCR.34582

A DMBA-induced ovarian cancer model: Could it be clinically useful to test OncoTherad and erythropoietin as anticancer approaches?

Journal of Clinical Oncology

DOI: 10.1200/JCO.2023.41.16_SUPPL.E17589

The Prognostic Effect of Immune Cell Infiltration Depends on Molecular Subtype in Endometrioid Ovarian Carcinomas

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-22-381

p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study

Journal of Pathology Clinical Research

DOI: 10.1002/CJP2.311

Methylation Signature Implicated in Immuno-Suppressive Activities in Tubo-Ovarian High-Grade Serous Carcinoma

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

DOI: 10.1158/1055-9965.EPI-22-0941

ADVISE: Endometrial and Ovarian Cancer screening using vaginal-based liquid biopsies

Bioinformatics, Interdisciplinary Oncology and Genome Science + Technology - BIG 22

Rushton C, Anna T, Senz J, Alcaide M, Shen C, Wan R, Ruffin K, Morin RD, Anglesio MS., ADVISE: Endometrial and Ovarian Cancer screening using vaginal-based liquid biopsies. Bioinformatics, Interdisciplinary Oncology and Genome Science + Technology - BIG 22; 2022 March 23, 2022; Vancouver, Canada: University of British Columbia.

03 / 2022

MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma

VIRCHOWS ARCHIV

DOI: 10.1007/S00428-021-03232-0

Prognostic and Theranostic Biomarkers in Ovarian Clear Cell Carcinoma

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

DOI: 10.1097/PGP.0000000000000780

Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.CCR-21-3817

Into the future: A pilot study combining imaging with molecular profiling to predict resectability in ovarian cancer

GYNECOLOGIC ONCOLOGY

DOI: 10.1016/J.YGYNO.2022.07.020

LYMPHADENECTOMY IN ENDOMETRIOID OVARIAN CARCINOMA PATIENTS WITH EARLY STAGE DISEASE: RESULTS FROM THE LEOPARD TRIAL

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

DOI: 10.1136/IJGC-2022-IGCS.33

Multisite gynecologic endometrioid adenocarcinomas: Can mutation profiling be used to distinguish synchronous primary cancers from metastases?

GYNECOLOGIC ONCOLOGY REPORTS

DOI: 10.1016/J.GORE.2022.101076

Immunohistochemical Profiles Including p53, MMR, PR and CTNNB1 are Associated with Survival of Patients Diagnosed with Ovarian Endometrioid Carcinoma

LABORATORY INVESTIGATION

The proteome of clear cell ovarian carcinoma

JOURNAL OF PATHOLOGY

DOI: 10.1002/PATH.6006

Multi-modal immune profiling of mucinous ovarian carcinoma: analysis from the Ovarian Tumor Tissue Analysis/Multidisciplinary Ovarian Cancer Outcomes Group consortia

JOURNAL OF IMMUNOLOGY

DOI: 10.4049/JIMMUNOL.208.SUPP.179.04

Molecular analysis suggests oligoclonality and metastasis of endometriosis lesions across anatomically defined subtypes

FERTILITY AND STERILITY

DOI: 10.1016/J.FERTNSTERT.2022.05.030

Metastasis in endometriosis: targeted sequencing suggests non-malignancy associated endometriosis is capable of wide dissemination

GEBURTSHILFE UND FRAUENHEILKUNDE

DOI: 10.1055/S-0042-1756999

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.CCR-22-1206

Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8+ TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas

JOURNAL OF PATHOLOGY

DOI: 10.1002/PATH.5849

Selection of endometrial carcinomas for p53 immunohistochemistry based on nuclear features

JOURNAL OF PATHOLOGY CLINICAL RESEARCH

DOI: 10.1002/CJP2.243

Somatic Genomic Events in Endometriosis: Review of the Literature and Approach to Phenotyping

Reproductive Sciences

Paul J. Yong and Aline Talhouk and Michael S. Anglesio

DOI: 10.1007/s43032-020-00451-9

10 / 2021

Pathogenesis of bowel endometriosis

Best Practice & Research Clinical Obstetrics & Gynaecology

Paul J. Yong and Mohamed A. Bedaiwy and Fahad Alotaibi and Michael S. Anglesio

DOI: 10.1016/j.bpobgyn.2020.05.009

03 / 2021

Molecular analysis suggests oligoclonality and metastasis of endometriosis lesions across anatomically defined subtypes.

medRxiv

DOI: 10.1101/2021.04.12.21255355

Prognostic and Immunological Significance of ARID1A Status in Endometriosis-Associated Ovarian Carcinoma

MedRxiv

DOI: 10.1101/2021.09.16.21262993

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

MODERN PATHOLOGY

DOI: 10.1038/S41379-020-0618-9

Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

DOI: 10.1007/S00432-021-03558-X

Pattern of invasion in stage I mucinous ovarian cancer is prognostic within 2-years of diagnosis

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

NUCLEAR FEATURES ALLOW FOR HIGHLY SENSITIVE SELECTION OF ENDOMETRIAL CARCINOMAS FOR P53 TESTING

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

DOI: 10.1136/IJGC-2021-IGCS.173

Prognostic and theragnostic biomarkers in ovarian clear cell carcinoma

Katharina Wiedemeyer and Linyuan Wang and Eun Young Kang and Shuhong Liu and Young Ou and Linda E. Kelemen and Lukas Feil and Michael S. Anglesio and Sarah Glaze and Prafull Ghatage and Gregg S. Nelson and Martin Kbel

DOI: 10.1101/2020.08.21.20178830

08 / 2020

Immunohistochemical Expression of L1CAM in Endometrioid Ovarian Cancer - A new Prognostic Marker?

GEBURTSHILFE UND FRAUENHEILKUNDE

DOI: 10.1055/S-0040-1718139

Application of the molecular Risk Stratification of the Endometrium to endometrioid Ovarian Carcinoma - a retrospective, international Multicenter Study

GEBURTSHILFE UND FRAUENHEILKUNDE

DOI: 10.1055/S-0040-1718219

The Ovarian Tumour Tissue Analysis Consortium: Stratified Prognosis of Ovarian Tumors (OTTA-SPOT) signature for high-grade serous ovarian cancer.

CLINICAL CANCER RESEARCH

The Ovarian Tumour Tissue Analysis Consortium: Stratified Prognosis of Ovarian Tumors (OTTA-SPOT) signature for high-grade serous ovarian cancer

Clinical Cancer Research

PrOTYPE (Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE): The development and validation of a clinical-grade consensus classifier for the molecular subtypes of high-grade serous tubo-ovarian cancer.

CLINICAL CANCER RESEARCH

Molecular stratification of clear cell ovarian carcinomas

GEBURTSHILFE UND FRAUENHEILKUNDE

DOI: 10.1055/S-0040-1718135

Endometrial cancer molecular risk stratification in endometrioid ovarian cancers: A novel application of precision medicine

Clinical Cancer Research

Histotype-specific analysis of acid ceramidase expression in ovarian cancer

VIRCHOWS ARCHIV

DOI: 10.1007/S00428-019-02728-0

Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.CCR-20-1268

STUDY IN PROGRESS: INTERNATIONAL RETROSPECTIVE STUDY ON LYMPHADENECTOMY IN ENDOMETRIOID OVARIAN CARCINOMA PATIENTS WITH EARLY STAGE DISEASE (LEOPARD)

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

DOI: 10.1136/IJGC-2020-IGCS.394

Prognostic gene expression signature for high-grade serous ovarian cancer

ANNALS OF ONCOLOGY

DOI: 10.1016/J.ANNONC.2020.05.019

Clinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium

BRITISH JOURNAL OF CANCER

DOI: 10.1038/S41416-020-0900-0

Changes in the Tumor Immune Microenvironment during Disease Progression in Patients with Ovarian Cancer

CANCERS

DOI: 10.3390/CANCERS12123828

Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.CCR-20-0103

Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival

GYNECOLOGIC ONCOLOGY

DOI: 10.1016/J.YGYNO.2020.06.481

Endometrial cancer molecular risk stratification in endometrioid ovarian cancers: A novel application of precision medicine.

CLINICAL CANCER RESEARCH

ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

CELL REPORTS

DOI: 10.1016/J.CELREP.2020.108366

PrOTYPE (Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE): The development and validation of a clinical-grade consensus classifier for the molecular subtypes of high-grade serous tubo-ovarian cancer

Clinical Cancer Research

DOI: 10.1158/1557-3265.OVCA19-A03

Is endometriosis metastasizing? Shared somatic alterations suggest common origins across endometriotic lesions

GEBURTSHILFE UND FRAUENHEILKUNDE

DOI: 10.1055/S-0040-1718045

The molecular origin and taxonomy of mucinous ovarian carcinoma

Nature Communications

Dane Cheasley and Matthew J. Wakefield and Georgina L. Ryland and Prue E. Allan and Kathryn Alsop and Kaushalya C. Amarasinghe and Sumitra Ananda and Michael S. Anglesio and George Au-Yeung and Maret Bhm and David D. L. Bowtell and Alison Brand and Georgia Chenevix-Trench and Michael Christie and Yoke-Eng Chiew and Michael Churchman and Anna DeFazio and Renee Demeo and Rhiannon Dudley and Nicole Fairweather and Clare G. Fedele and Sian Fereday and Stephen B. Fox and C Blake Gilks and Charlie Gourley and Neville F. Hacker and Alison M. Hadley and Joy Hendley and Gwo-Yaw Ho and Siobhan Hughes and David G. Hunstman and Sally M. Hunter and Tom W. Jobling and Kimberly R. Kalli and Scott H. Kaufmann and Catherine J. Kennedy and Martin Kbel and Cecile Le Page and Jason Li and Richard Lupat and Orla M. McNally and Jessica N. McAlpine and Anne-Marie Mes-Masson and Linda Mileshkin and Diane M. Provencher and Jan Pyman and Kurosh Rahimi and Simone M. Rowley and Carolina Salazar and Goli Samimi

DOI: 10.1038/s41467-019-11862-x

09 / 2019

TRANSLATING ENDOMETRIAL MOLECULAR RISK STRATIFICATION TO ENDOMETRIOID OVARIAN CARCINOMA: A NOVEL APPLICATION OF PRECISION MEDICINE

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

DOI: 10.1136/IJGC-2019-IGCS.3

THE PROGNOSTIC IMPACT OF SPHINGOSINE-KINASE 1 EXPRESSION (SPHK1) ON OVARIAN CANCER

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

DOI: 10.1136/IJGC-2019-ESGO.882

Prognostic and Immunological Significance of ARID1A Status in Endometriosis-Associated Ovarian Cancers

MODERN PATHOLOGY

A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases

MODERN PATHOLOGY

DOI: 10.1038/S41379-019-0302-0

Nuclear -catenin and CDX2 expression in ovarian endometrioid carcinoma identify patients with favourable outcome

HISTOPATHOLOGY

DOI: 10.1111/HIS.13772

Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.CCR-18-3241

Fibroblast growth factor receptor 4 (FGFR4) as detected by immunohistochemistry is associated with postoperative residual disease in ovarian cancer

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

DOI: 10.1007/S00432-019-02986-0

APPLICATION OF PRECISION MEDICINE: CAN MOLECULAR RISK STRATIFICATION PROVIDE NEW MANAGEMENT OPTIONS FOR LOW STAGE ENDOMETRIOID OVARIAN CARCINOMA?

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

DOI: 10.1136/IJGC-2019-ESGO.41

Molecular Classification of Epithelial Ovarian Cancer Based on Methylation Profiling: Evidence for Survival Heterogeneity

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.CCR-18-3720

Optimized molecular risk stratification for ovarian endometrioid carcinomas

Modern Pathology

Oncogenic mutations in histologically normal endometrium: the new normal?

JOURNAL OF PATHOLOGY

DOI: 10.1002/PATH.5314

Iatrogenic endometriosis harbors somatic cancer-driver mutations

HUMAN REPRODUCTION

DOI: 10.1093/HUMREP/DEY332

HACE1 is a potential tumor suppressor in osteosarcoma

CELL DEATH & DISEASE

DOI: 10.1038/S41419-018-1276-4

Advanced Methods for Cancer Detection by Vaginal Screening (ADVISE): Feasibility and Assessment of Deep-Sequencing Based Self-Sampling Methods

British Columbia Cancer Symposium

Rushton C, Tinker AV, Yang W, Yun JP, Rufin K, Alcaide M, Morin RD, Anglesio MS., Advanced Methods for Cancer Detection by Vaginal Screening (ADVISE): Feasibility and Assessment of Deep-Sequencing Based Self-Sampling Methods. British Columbia Cancer Symposium; 2018; Vancouver, BC, Canada: BCCA.

11 / 2018

You won't believe this old test that does cheap single-cell mutation detection

The Journal of Pathology: Clinical Research

Martin Kbel and Michael S. Anglesio and James D. Brenton

DOI: 10.1002/cjp2.108

07 / 2018

Extrauterine high-grade serous carcinomas with bilateral adnexal involvement as the only two disease sites are clonal based on tp53 sequencing results: implications for biology, classification, and staging

Modern Pathology

Naveena Singh and Asma Faruqi and Friedrich Kommoss and W Glenn McCluggage and Giorgia Trevisan and Janine Senz and Amy Lum and C Blake Gilks and Michael Anglesio

DOI: 10.1038/modpathol.2017.159

04 / 2018

Disease Distribution in Low-stage Tubo-ovarian High-grade Serous Carcinoma (HGSC): Implications for Assigning Primary Site and FIGO Stage

International Journal of Gynecological Pathology

DOI: 10.1097/PGP.0000000000000429

Endometriosis and endometriosis-associated cancers: new insights into the molecular mechanisms of ovarian cancer development

ECANCERMEDICALSCIENCE

DOI: 10.3332/ECANCER.2018.803

Capturing L1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers as a way to track tumor development.

CLINICAL CANCER RESEARCH

Cancer Associated Mutations in Eutopic Endometrium

LABORATORY INVESTIGATION

CLINICAL AND MOLECULAR CHARACTERIZATION OF SYNCHRONOUS ENDOMETRIAL AND OVARIAN CARCINOMAS

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Capturing L1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers as a way to track tumor development

Clinical Cancer Research

Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study

JOURNAL OF PATHOLOGY CLINICAL RESEARCH

DOI: 10.1002/CJP2.109

A gene expression prognostic signature for overall survival in patients with high-grade serous ovarian cancer.

JOURNAL OF CLINICAL ONCOLOGY

DOI: 10.1200/JCO.2018.36.15_SUPPL.5583

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

CELL

DOI: 10.1016/J.CELL.2018.03.073

Histotype classification of ovarian carcinoma: A comparison of approaches

GYNECOLOGIC ONCOLOGY

DOI: 10.1016/J.YGYNO.2018.08.016

Somatic Cancer-Driver Alterations Among Benign Endometriosis Subtypes

MODERN PATHOLOGY

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes

Nature Genetics

Yi Kan Wang and Ali Bashashati and Michael S Anglesio and Dawn R Cochrane and Diljot S Grewal and Gavin Ha and Andrew McPherson and Hugo M Horlings and Janine Senz and Leah M Prentice and Anthony N Karnezis and Daniel Lai and Mohamed R Aniba and Allen W Zhang and Karey Shumansky and Celia Siu and Adrian Wan and Melissa K McConechy and Hector Li-Chang and Alicia Tone and Diane Provencher and Manon de Ladurantaye and Hubert Fleury and Aikou Okamoto and Satoshi Yanagida and Nozomu Yanaihara and Misato Saito and Andrew J Mungall and Richard Moore and Marco A Marra and C Blake Gilks and Anne-Marie Mes-Masson and Jessica N McAlpine and Samuel Aparicio and David G Huntsman and Sohrab P Shah

DOI: 10.1038/ng.3849

06 / 2017

Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma

MOLECULAR CANCER RESEARCH

DOI: 10.1158/1541-7786.MCR-16-0132

Identical TP53 mutations provide evidence that late-recurring tubo-ovarian high-grade serous carcinomas do not represent new peritoneal primaries

HISTOPATHOLOGY

DOI: 10.1111/HIS.13327

EXPRESSION OF ACID CERAMIDASE (ASAH1) AS A PROGNOSTIC FACTOR IN OVARIAN CANCER

International Journal of Gynecological Cancer

Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation

PLOS ONE

DOI: 10.1371/JOURNAL.PONE.0178989

Cancer-Associated Mutations in Endometriosis without Cancer

NEW ENGLAND JOURNAL OF MEDICINE

DOI: 10.1056/NEJMOA1614814

APELA promotes tumour growth and cell migration in ovarian cancer in a p53-dependent manner

GYNECOLOGIC ONCOLOGY

DOI: 10.1016/J.YGYNO.2017.10.016

LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers

GYNECOLOGIC ONCOLOGY

DOI: 10.1016/J.YGYNO.2017.09.032

Endometriosis-associated Ovarian Cancers

CLINICAL OBSTETRICS AND GYNECOLOGY

DOI: 10.1097/GRF.0000000000000320

Enhanced GAB2 Expression Is Associated with Improved Survival in High-grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition (vol 14, pg 1495, 2015)

MOLECULAR CANCER THERAPEUTICS

DOI: 10.1158/1535-7163.MCT-17-0067

Confirmation of ProMisE: A Simple, Genomics-Based Clinical Classifier for Endometrial Cancer

CANCER

DOI: 10.1002/CNCR.30496

Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver (vol 20, pg 6618, 2014)

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.CCR-16-0992

IS ENDOMETRIOSIS A NEOPLASM AND IS THERE AN OPPORTUNITY FOR A BIOLOGICALLY INFORMED CLASSIFICATION SYSTEM?

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Single-Patient Molecular Testing with NanoString nCounter Data Using a Reference-Based Strategy for Batch Effect Correction

PLOS ONE

DOI: 10.1371/JOURNAL.PONE.0153844

BAF250a Expression in Atypical Endometriosis and Endometriosis-Associated Ovarian Cancer

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

DOI: 10.1097/IGC.0000000000000698

Genomics analyses of less common epithelial ovarian cancer subtypes.

CLINICAL CANCER RESEARCH

DOI: 10.1158/1557-3265.OVCA15-B08

Differences in MEK inhibitor efficacy in molecularly characterized low-grade serous ovarian cancer cell lines

AMERICAN JOURNAL OF CANCER RESEARCH

Synchronous ovarian and endometrial carcinomas: The case for pseudo-metastasis

CLINICAL CANCER RESEARCH

DOI: 10.1158/1557-3265.OVCA15-PR07

Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

DOI: 10.1093/JNCI/DJV428

Genomic consequences of aberrant DNA repair stratify ovarian cancer histotypes

CANCER RESEARCH

DOI: 10.1158/1538-7445.AM2016-LB-324

Recurrent DICER1 Hotspot Mutations in Endometrial Tumours And Their Impact on MicroRNA Biogenesis.

Chen J and Wang Y and McMonechy MK and Anglesio MS and Yang W and Senz J and Maines-Bandiera S and Rosner J and Trigo-Gonzalez G and Grace Cheng SW and Kim J and Matzuk MM and Morin GB and Huntsman DG

PubMed: 26033159

06 / 2015

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

MOLECULAR CANCER THERAPEUTICS

DOI: 10.1158/1535-7163.MCT-15-0039

Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

DOI: 10.1097/IGC.0000000000000492

Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes

ONCOTARGET

DOI: 10.18632/ONCOTARGET.5438

The oncogenic role of DICER1 RNase IIIb domain mutations in ovarian sertoli-leydig cell tumors

CLINICAL CANCER RESEARCH

DOI: 10.1158/1557-3265.OVCASYMP14-POSTER-BIOL-1349

Morphologic and Molecular Characteristics of Mixed Epithelial Ovarian Cancers

AMERICAN JOURNAL OF SURGICAL PATHOLOGY

DOI: 10.1097/PAS.0000000000000476

Molecular Characteristics of Mixed Ovarian Carcinomas

MODERN PATHOLOGY

The Oncogenic Roles of DICER1 RNase IIIb Domain Mutations in Ovarian Sertoli-Leydig Cell Tumors

NEOPLASIA

DOI: 10.1016/J.NEO.2015.08.003

The somatic mutational landscape of endometriosis associated ovarian cancers and precursor lesions

CLINICAL CANCER RESEARCH

DOI: 10.1158/1557-3265.OVCASYMP14-AS18

Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms

BMC CANCER

DOI: 10.1186/S12885-015-1421-8

Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden

JOURNAL OF PATHOLOGY

DOI: 10.1002/PATH.4516

Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis

JOURNAL OF PATHOLOGY

DOI: 10.1002/PATH.4569

A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary

HISTOPATHOLOGY

DOI: 10.1111/HIS.12253

PROGNOSTIC MARKERS FOR HIGH GRADE SEROUS OVARIAN CANCER AND VALIDATION USING LARGE SCALE NANOSTRING EXPRESSION PROFILING: AN OTTA CONSORTIUM STUDY

International Journal of Gynecological Cancer

Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.CCR-14-1292

Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study

BRITISH JOURNAL OF CANCER

DOI: 10.1038/BJC.2014.567

Recurrent DICER1 hotspot mutations in endometrial cancer and their impact on microRNA biogenesis

CANCER RESEARCH

DOI: 10.1158/1538-7445.AM2014-544

ENHANCED GAB2 EXPRESSION IS CHARACTERISTIC OF A CLINICALLY DISTINCT PI3K-DEPENDENT SUBTYPE OF HIGH-GRADE SEROUS AND ENDOMETRIOID OVARIAN CANCER

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

PRACTICAL TECHNOLOGIES FOR MOLECULAR-BASED CLASSIFICATION TO IMPROVE MANAGEMENT IN WOMEN WITH ENDOMETRIAL CANCER

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

EXOME SEQUENCING OF LOW GRADE SEROUS OVARIAN TUMOURS

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

The somatic mutational landscape of ovarian clear cell carcinoma and its precursor lesions

CANCER RESEARCH

DOI: 10.1158/1538-7445.AM2014-LB-312

PROGNOSTIC MARKERS FOR HIGH GRADE SEROUS OVARIAN CANCER AND VALIDATION USING LARGE SCALE NANOSTRING EXPRESSION PROFILING: AN OTTA CONSORTIUM STUDY.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Harnessing the potential of lipid-based nanomedicines for type-specific ovarian cancer treatments

NANOMEDICINE

DOI: 10.2217/NNM.13.220

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

BMC CANCER

DOI: 10.1186/1471-2407-14-120

Markers of T Cell Infiltration and Function Associate with Favorable Outcome in Vascularized High-Grade Serous Ovarian Carcinoma

PLOS ONE

DOI: 10.1371/JOURNAL.PONE.0082406

Correction: Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research.

Anglesio MS and Wiegand KC and Melnyk N and Chow C and Salamanca C and Prentice LM and Senz J and Yang W and Spillman MA and Cochrane DR and Shumansky K and Shah SP and Kalloger SE and Huntsman DG

PubMed: 24116245

FOXL2 molecular testing in ovarian neoplasms: diagnostic approach and procedural guidelines

MODERN PATHOLOGY

DOI: 10.1038/MODPATHOL.2012.226

Molecular profiling of low grade serous ovarian tumors

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.OVCA13-A13

The ovarian tumor tissue analysis (OTTA) consortium

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.OVCA13-A27

Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas

JOURNAL OF PATHOLOGY

DOI: 10.1002/PATH.4088

Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

LANCET ONCOLOGY

DOI: 10.1016/S1470-2045(13)70253-5

Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling

JOURNAL OF PATHOLOGY

DOI: 10.1002/PATH.4230

Defining ovarian mucinous tumors: Cancer genes and heterogeneity

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.OVCA13-A18

Accelerating type-specific ovarian carcinoma research: Calculator for Ovarian Subtype Prediction (COSP) is a reliable high-throughput tool for case review

HISTOPATHOLOGY

DOI: 10.1111/HIS.12219

A CURRENT PERSPECTIVE ON THE PATHOLOGICAL ASSESSMENT OF ADULT-TYPE GRANULOSA CELL TUMORS OF THE OVARY

International Journal of Gynecological Cancer

Rapid RNA-based histotyping of ovarian carcinomas

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.OVCA13-B14

A CURRENT PERSPECTIVE ON THE PATHOLOGICAL ASSESSMENT OF ADULT-TYPE GRANULOSA CELL TUMORS OF THE OVARY.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research

PLOS ONE

DOI: 10.1371/JOURNAL.PONE.0072162

Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage

JOURNAL OF PATHOLOGY

DOI: 10.1002/PATH.4135

Cytokine gene expression signature in ovarian clear cell carcinoma

INTERNATIONAL JOURNAL OF ONCOLOGY

DOI: 10.3892/IJO.2012.1533

Benign serous ovarian tumour: a redefining moment?

Hunter S and Gorringe K and Anglesio M and Sharma R and Gilks B and deFazio A and Huntsman D and Campbell I

LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

CANCER RESEARCH

DOI: 10.1158/0008-5472.CAN-12-0203

Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers

NEW ENGLAND JOURNAL OF MEDICINE

DOI: 10.1056/NEJMOA1102903

The autophagy protein LC3A correlates with hypoxia and is a prognostic marker of patient survival in clear cell ovarian cancer

JOURNAL OF PATHOLOGY

DOI: 10.1002/PATH.4090

FOXL2 Molecular Testing in the Diagnosis of Ovarian Neoplasms

Laboratory Investigation

Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers

PLOS ONE

DOI: 10.1371/JOURNAL.PONE.0018064

Benign ovarian serous tumors: A redefining moment

CANCER RESEARCH

DOI: 10.1158/1538-7445.AM2011-LB-271

Clear cell carcinoma of the ovary: A report from the first Ovarian Clear Cell Symposium, June 24th, 2010

GYNECOLOGIC ONCOLOGY

DOI: 10.1016/J.YGYNO.2011.01.005

IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.CCR-10-3314

Copy Number Aberrations in Benign Serous Ovarian Tumors: A Case for Reclassification?

CLINICAL CANCER RESEARCH

DOI: 10.1158/1078-0432.CCR-11-2080

Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas

JOURNAL OF PATHOLOGY

DOI: 10.1002/PATH.2848

Identification of somatic mutations of the PPP2R1A gene in subtypes of endometrial and ovarian carcinomas

CANCER RESEARCH

DOI: 10.1158/1538-7445.AM2011-924

Using the right tools: A catalog of ovarian cancer cell lines by subtype

CANCER RESEARCH

DOI: 10.1158/1538-7445.AM2011-4289

Copy Number Analysis Identifies Novel Interactions Between Genomic Loci in Ovarian Cancer

PLOS ONE

DOI: 10.1371/JOURNAL.PONE.0011408

Profiling the Cancer Genome

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 11

DOI: 10.1146/ANNUREV-GENOM-082509-141536

ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

NEW ENGLAND JOURNAL OF MEDICINE

DOI: 10.1056/NEJMOA1008433

A dysregulated pathway underlying a novel molecular subtype of ovarian cancer

EJC SUPPLEMENTS

DOI: 10.1016/S1359-6349(09)70314-3

Are There Any More Ovarian Tumor Suppressor Genes? A New Perspective Using Ultra High-Resolution Copy Number and Loss of Heterozygosity Analysis

GENES CHROMOSOMES & CANCER

DOI: 10.1002/GCC.20694

Mutation of ERBB2 Provides a Novel Alternative Mechanism for the Ubiquitous Activation of RAS-MAPK in Ovarian Serous Low Malignant Potential Tumors

MOLECULAR CANCER RESEARCH

DOI: 10.1158/1541-7786.MCR-08-0193

The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers

NATURE MEDICINE

DOI: 10.1038/NM1621

Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species

MOLECULAR AND CELLULAR BIOLOGY

DOI: 10.1128/MCB.26.1.277-292.2006

Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney

HUMAN MOLECULAR GENETICS

DOI: 10.1093/HMG/DDH215

Influence of "cancer driver" somatic mutation on the immune microenvironment of endometriosis and endoemtriosis-associated ovarian cancers

Prevelance of "cancer driver" somatic mutations in endometriosis subtypes, as well as the association of somatic mutations with clinical factors such as pain

Grants

CIHR Early Career Investigator Operating Grant: Endometriosis Microenvironment: Influence of "Cancer-Driver" Mutations

NIH R37 Project Grant (Co-Applicant): High-throughput Epigenomic Mapping of Regulatory Elements in Ovarian Cancer at Basepair Resolution

CIHR Project Grant (Co-Pl): Sexual Pain in Endometriosis: Role of Somatic Mutations and Local Neurogenesis

Honours & Awards

2016/5 - Department of Pathology and Laboratory Medicine Award for Excellence in Mentoring, University of British Columbia

2019/1- Most impactful paper published in 2017 from the Columbia Hospital for Women Research Foundation (CHWRF) with reference to: Anglesio et al. N Eng J Med 2017. Cancer-Associated Mutations in Endometriosis without Cancer

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